SIMILAR PATTERNS OF AMINO ACIDS FOR 4MXZ_A_DB8A601_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k2p TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 416
ALA A 428
LYS A 430
VAL A 458
ILE A 472
TYR A 476
GLY A 480
LEU A 528
 None
 0.69A 4mxzA-1k2pA:
25.8		 4mxzA-1k2pA:
37.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		9 VAL A 209
ALA A 220
GLU A 236
VAL A 249
ILE A 264
TYR A 268
GLY A 272
LEU A 321
ASP A 332
 None
 0.69A 4mxzA-1k9aA:
33.4		 4mxzA-1k9aA:
29.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 VAL A 209
ALA A 220
LYS A 222
ILE A 264
TYR A 268
GLY A 272
LEU A 321
ASP A 332
 None
 0.59A 4mxzA-1k9aA:
33.4		 4mxzA-1k9aA:
29.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  15
VAL A  23
ALA A  36
GLU A  55
TYR A  86
GLY A  90
LEU A 137
ASP A 148
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
None
HYM  A 400 (-4.7A)
None
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
 0.96A 4mxzA-1zltA:
16.7		 4mxzA-1zltA:
26.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A  23
ALA A  36
GLU A  55
VAL A  68
TYR A  86
GLY A  90
LEU A 137
ASP A 148
 HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
None
HYM  A 400 (-4.8A)
HYM  A 400 (-4.7A)
None
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
 0.87A 4mxzA-1zltA:
16.7		 4mxzA-1zltA:
26.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU X  17
VAL X  25
ALA X  37
GLU X  54
VAL X  67
ILE X  80
TYR X  84
GLY X  88
LEU X 137
ASP X 148
 STU  X 902 (-3.8A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
None
STU  X 902 (-4.6A)
STU  X 902 (-3.5A)
STU  X 902 (-4.4A)
STU  X 902 (-3.6A)
 0.85A 4mxzA-2dq7X:
37.4		 4mxzA-2dq7X:
83.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU X  17
VAL X  25
ALA X  37
LYS X  39
VAL X  67
ILE X  80
TYR X  84
GLY X  88
LEU X 137
ASP X 148
 STU  X 902 (-3.8A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
None
None
STU  X 902 (-4.6A)
STU  X 902 (-3.5A)
STU  X 902 (-4.4A)
STU  X 902 (-3.6A)
 0.80A 4mxzA-2dq7X:
37.4		 4mxzA-2dq7X:
83.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		9 LEU A 273
VAL A 281
ALA A 293
VAL A 323
ILE A 336
TYR A 340
GLY A 344
LEU A 393
ASP A 404
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
None
H8H  A 534 ( 4.5A)
H8H  A 534 (-4.3A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 (-4.2A)
 0.54A 4mxzA-2h8hA:
34.5		 4mxzA-2h8hA:
52.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 251
VAL A 259
ALA A 271
LYS A 273
GLU A 288
VAL A 301
ILE A 314
GLY A 322
LEU A 371
ASP A 382
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
None
1BM  A 499 (-3.9A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 (-4.4A)
 0.64A 4mxzA-2hk5A:
28.4		 4mxzA-2hk5A:
66.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 248
VAL A 256
ALA A 269
VAL A 299
ILE A 313
GLY A 321
LEU A 370
ASP A 381
 GIN  A 600 ( 4.6A)
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-4.6A)
GIN  A 600 (-3.8A)
None
GIN  A 600 (-4.7A)
GIN  A 600 (-4.9A)
 0.87A 4mxzA-2hz0A:
33.3		 4mxzA-2hz0A:
47.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		8 VAL A 436
ALA A 452
LYS A 454
VAL A 484
ILE A 497
GLY A 505
LEU A 553
ASP A 564
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
None
None
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
4ST  A1687 (-4.7A)
 0.93A 4mxzA-2j0jA:
32.4		 4mxzA-2j0jA:
18.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 596
ALA A 614
GLU A 633
VAL A 647
TYR A 665
GLY A 669
LEU A 785
ASP A 796
 None
 0.96A 4mxzA-2ogvA:
29.4		 4mxzA-2ogvA:
34.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qkw PROTEIN KINASE

(Solanum
pimpinellifolium) 		PF07714
(Pkinase_Tyr) 		8 VAL B  55
ALA B  67
GLU B  85
VAL B  98
TYR B 116
GLY B 120
LEU B 171
ASP B 182
 None
 0.66A 4mxzA-2qkwB:
26.0		 4mxzA-2qkwB:
30.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		8 ALA A 103
GLU A 124
VAL A 137
MET A 153
TYR A 155
GLY A 159
LEU A 205
ASP A 216
 ANP  A1480 ( 3.9A)
None
ANP  A1480 (-4.7A)
ANP  A1480 (-4.1A)
ANP  A1480 ( 4.9A)
None
ANP  A1480 ( 4.7A)
ANP  A1480 (-3.5A)
 0.91A 4mxzA-2v55A:
20.5		 4mxzA-2v55A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk SERINE/THREONINE-PRO
TEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU C  55
VAL C  63
ALA C  76
LYS C  78
GLU C  98
MET C 129
TYR C 131
LEU C 183
 ANP  C   2 ( 4.4A)
ANP  C   2 (-4.2A)
ANP  C   2 (-3.4A)
ANP  C   2 (-3.6A)
None
None
None
None
 0.95A 4mxzA-2wtkC:
17.6		 4mxzA-2wtkC:
28.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		10 VAL A  34
ALA A  47
LYS A  49
GLU A  66
ILE A  93
MET A  95
TYR A  97
GLY A 101
LEU A 147
ASP A 158
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
None
J60  A1294 ( 3.8A)
J60  A1294 (-4.5A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.6A)
 0.83A 4mxzA-2xikA:
20.3		 4mxzA-2xikA:
30.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2w WEE1-LIKE PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A 313
ALA A 326
GLU A 346
VAL A 360
ILE A 374
TYR A 378
GLY A 382
ASP A 463
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 (-3.9A)
770  A 901 ( 4.7A)
None
770  A 901 (-4.2A)
770  A 901 (-3.4A)
770  A 901 (-3.8A)
 0.83A 4mxzA-2z2wA:
20.7		 4mxzA-2z2wA:
25.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		9 LEU A 253
VAL A 261
ALA A 273
GLU A 290
VAL A 303
ILE A 317
GLY A 325
LEU A 374
ASP A 385
 None
 0.69A 4mxzA-2zv7A:
37.2		 4mxzA-2zv7A:
63.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL A 209
ALA A 220
GLU A 236
VAL A 249
ILE A 264
TYR A 268
GLY A 272
LEU A 321
ASP A 332
 None
 0.69A 4mxzA-3d7uA:
27.3		 4mxzA-3d7uA:
40.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 209
ALA A 220
LYS A 222
ILE A 264
TYR A 268
GLY A 272
LEU A 321
ASP A 332
 None
 0.59A 4mxzA-3d7uA:
27.3		 4mxzA-3d7uA:
40.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		8 VAL A 647
ALA A 663
LYS A 665
GLU A 682
VAL A 695
ILE A 709
GLY A 717
LEU A 765
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 (-3.8A)
IHZ  A1001 ( 4.9A)
None
IHZ  A1001 ( 3.9A)
IHZ  A1001 (-4.6A)
 0.76A 4mxzA-3dkoA:
32.2		 4mxzA-3dkoA:
41.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A 217
ALA A 228
LYS A 230
GLU A 243
TYR A 281
GLY A 285
LEU A 340
ASP A 351
 ADP  A 900 (-4.3A)
ADP  A 900 (-3.4A)
ADP  A 900 (-2.8A)
ADP  A 900 ( 4.7A)
None
ADP  A 900 ( 4.2A)
ADP  A 900 (-4.6A)
ADP  A 900 ( 2.7A)
 0.67A 4mxzA-3g2fA:
27.1		 4mxzA-3g2fA:
26.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		8 VAL A 649
ALA A 665
LYS A 667
ILE A 711
TYR A 715
GLY A 719
LEU A 767
ASP A 778
 None
None
None
None
GOL  A 403 (-4.1A)
GOL  A 403 (-3.4A)
None
None
 0.80A 4mxzA-3kulA:
34.9		 4mxzA-3kulA:
38.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		8 LEU A 680
VAL A 689
ALA A 700
LYS A 702
GLU A 715
ILE A 743
LEU A 804
ASP A 828
 ADP  A2101 ( 4.1A)
ADP  A2101 (-4.5A)
ADP  A2101 (-3.5A)
ADP  A2101 (-2.7A)
None
None
ADP  A2101 (-4.4A)
SR  A2103 (-2.6A)
 0.94A 4mxzA-3lj0A:
24.5		 4mxzA-3lj0A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		8 LEU A 192
VAL A 200
ALA A 213
GLU A 234
VAL A 247
GLY A 269
LEU A 318
ASP A 329
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
None
None
None
AMP  A 577 (-4.8A)
AMP  A 577 (-4.0A)
 0.76A 4mxzA-3nyoA:
20.4		 4mxzA-3nyoA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		8 LEU A 192
VAL A 200
ALA A 213
LYS A 215
GLU A 234
GLY A 269
LEU A 318
ASP A 329
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
AMP  A 577 (-4.8A)
AMP  A 577 (-4.0A)
 0.81A 4mxzA-3nyoA:
20.4		 4mxzA-3nyoA:
21.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		8 VAL A 565
ALA A 576
LYS A 578
GLU A 596
VAL A 609
ILE A 623
TYR A 627
ASP A 694
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
None
STU  A   1 (-4.4A)
STU  A   1 (-3.5A)
 0.89A 4mxzA-3ppzA:
31.4		 4mxzA-3ppzA:
32.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		9 VAL A 565
ALA A 576
LYS A 578
VAL A 609
ILE A 623
TYR A 627
GLY A 631
LEU A 683
ASP A 694
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
STU  A   1 (-4.4A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
 0.53A 4mxzA-3ppzA:
31.4		 4mxzA-3ppzA:
32.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 423
VAL A 431
ALA A 443
VAL A 473
ILE A 487
TYR A 491
GLY A 495
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
None
PP2  A   1 (-3.6A)
PP2  A   1 ( 4.9A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.64A 4mxzA-3sxsA:
33.2		 4mxzA-3sxsA:
42.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A1951
VAL A1959
ALA A1978
LYS A1980
ILE A2024
GLY A2032
LEU A2086
ASP A2102
 VGH  A3000 ( 4.4A)
None
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
None
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
None
 0.57A 4mxzA-3zbfA:
32.8		 4mxzA-3zbfA:
40.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 560
VAL A 568
ALA A 586
LYS A 588
VAL A 617
TYR A 635
GLY A 639
LEU A 699
 LTI  A1839 ( 4.2A)
None
LTI  A1839 (-3.3A)
None
None
LTI  A1839 (-4.7A)
LTI  A1839 (-3.4A)
LTI  A1839 (-4.2A)
 0.79A 4mxzA-4at3A:
29.6		 4mxzA-4at3A:
34.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 560
VAL A 568
ALA A 586
VAL A 617
TYR A 635
GLY A 639
LEU A 699
ASP A 710
 LTI  A1839 ( 4.2A)
None
LTI  A1839 (-3.3A)
None
LTI  A1839 (-4.7A)
LTI  A1839 (-3.4A)
LTI  A1839 (-4.2A)
None
 0.75A 4mxzA-4at3A:
29.6		 4mxzA-4at3A:
34.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  42
VAL A  50
ALA A  63
GLU A  81
VAL A  94
ILE A 108
GLY A 116
LEU A 164
 XZN  A1317 (-3.6A)
XZN  A1317 ( 4.7A)
XZN  A1317 (-3.5A)
XZN  A1317 (-3.9A)
XZN  A1317 (-4.4A)
XZN  A1317 (-4.4A)
XZN  A1317 ( 3.7A)
XZN  A1317 (-4.7A)
 0.96A 4mxzA-4bc6A:
23.0		 4mxzA-4bc6A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		8 LEU A 663
VAL A 671
ALA A 684
GLU A 705
VAL A 721
TYR A 739
LEU A 789
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 0.85A 4mxzA-4crsA:
22.7		 4mxzA-4crsA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		8 LEU A 663
VAL A 671
ALA A 684
LYS A 686
GLU A 705
TYR A 739
LEU A 789
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 0.93A 4mxzA-4crsA:
22.7		 4mxzA-4crsA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		8 LEU A 663
VAL A 671
ALA A 684
LYS A 686
TYR A 739
GLY A 743
LEU A 789
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 0.83A 4mxzA-4crsA:
22.7		 4mxzA-4crsA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		8 LEU A 663
VAL A 671
ALA A 684
VAL A 721
TYR A 739
GLY A 743
LEU A 789
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 0.81A 4mxzA-4crsA:
22.7		 4mxzA-4crsA:
25.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		8 VAL A 575
ALA A 588
VAL A 620
ILE A 634
MET A 636
GLY A 642
LEU A 690
ASP A 701
 GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
None
None
GUI  A 901 ( 4.8A)
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
 0.53A 4mxzA-4e93A:
28.4		 4mxzA-4e93A:
33.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		8 VAL A 575
GLU A 607
VAL A 620
ILE A 634
MET A 636
GLY A 642
LEU A 690
ASP A 701
 GUI  A 901 (-4.5A)
None
None
None
GUI  A 901 ( 4.8A)
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
 0.62A 4mxzA-4e93A:
28.4		 4mxzA-4e93A:
33.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 515
VAL A 523
ALA A 541
LYS A 543
VAL A 572
TYR A 590
GLY A 594
LEU A 656
 None
 0.60A 4mxzA-4f0iA:
23.2		 4mxzA-4f0iA:
34.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 515
VAL A 523
ALA A 541
VAL A 572
TYR A 590
GLY A 594
LEU A 656
ASP A 667
 None
 0.77A 4mxzA-4f0iA:
23.2		 4mxzA-4f0iA:
34.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 377
VAL A 385
ALA A 400
GLU A 420
VAL A 433
MET A 448
GLY A 454
LEU A 501
ASP A 512
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
None
None
0SB  A 701 (-3.6A)
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
0SB  A 701 (-3.9A)
 0.54A 4mxzA-4f4pA:
33.2		 4mxzA-4f4pA:
36.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A1122
VAL A1130
ALA A1148
GLU A1167
VAL A1180
ILE A1194
GLY A1202
LEU A1256
ASP A1270
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
None
0UV  A1501 ( 4.9A)
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
0UV  A1501 ( 4.2A)
 0.85A 4mxzA-4fodA:
31.1		 4mxzA-4fodA:
34.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3f NF-KAPPA-BETA-INDUCI
NG KINASE

(Mus musculus) 		PF00069
(Pkinase) 		8 VAL A 416
ALA A 429
LYS A 431
VAL A 455
ILE A 469
GLY A 477
LEU A 524
ASP A 536
 0WB  A 701 (-4.4A)
0WB  A 701 (-3.3A)
0WB  A 701 (-3.0A)
None
0WB  A 701 (-3.9A)
0WB  A 701 ( 4.5A)
0WB  A 701 (-4.3A)
0WB  A 701 (-3.1A)
 0.82A 4mxzA-4g3fA:
24.3		 4mxzA-4g3fA:
26.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		10 LEU A 855
VAL A 863
ALA A 880
LYS A 882
GLU A 898
VAL A 911
TYR A 931
GLY A 935
LEU A 983
ASP A 994
 IZA  A2001 (-3.7A)
None
IZA  A2001 (-3.4A)
IZA  A2001 ( 4.7A)
None
None
None
IZA  A2001 (-3.3A)
IZA  A2001 ( 4.7A)
IZA  A2001 ( 4.5A)
 0.93A 4mxzA-4gl9A:
30.0		 4mxzA-4gl9A:
31.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		10 VAL A 863
ALA A 880
LYS A 882
GLU A 898
VAL A 911
MET A 929
TYR A 931
GLY A 935
LEU A 983
ASP A 994
 None
IZA  A2001 (-3.4A)
IZA  A2001 ( 4.7A)
None
None
IZA  A2001 (-4.4A)
None
IZA  A2001 (-3.3A)
IZA  A2001 ( 4.7A)
IZA  A2001 ( 4.5A)
 0.84A 4mxzA-4gl9A:
30.0		 4mxzA-4gl9A:
31.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 853
GLU A 871
VAL A 884
MET A 902
TYR A 904
GLY A 908
LEU A 956
ASP A 967
 19S  A1201 (-3.3A)
None
None
19S  A1201 (-3.6A)
19S  A1201 (-4.7A)
19S  A1201 ( 3.8A)
19S  A1201 (-4.5A)
19S  A1201 ( 4.1A)
 0.87A 4mxzA-4hviA:
24.8		 4mxzA-4hviA:
34.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 853
LYS A 855
VAL A 884
MET A 902
TYR A 904
GLY A 908
LEU A 956
ASP A 967
 19S  A1201 (-3.3A)
19S  A1201 (-3.5A)
None
19S  A1201 (-3.6A)
19S  A1201 (-4.7A)
19S  A1201 ( 3.8A)
19S  A1201 (-4.5A)
19S  A1201 ( 4.1A)
 0.83A 4mxzA-4hviA:
24.8		 4mxzA-4hviA:
34.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 828
VAL A 836
ALA A 853
GLU A 871
VAL A 884
TYR A 904
GLY A 908
LEU A 956
ASP A 967
 19S  A1201 (-3.9A)
19S  A1201 (-4.4A)
19S  A1201 (-3.3A)
None
None
19S  A1201 (-4.7A)
19S  A1201 ( 3.8A)
19S  A1201 (-4.5A)
19S  A1201 ( 4.1A)
 1.11A 4mxzA-4hviA:
24.8		 4mxzA-4hviA:
34.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 828
VAL A 836
ALA A 853
LYS A 855
VAL A 884
TYR A 904
GLY A 908
LEU A 956
ASP A 967
 19S  A1201 (-3.9A)
19S  A1201 (-4.4A)
19S  A1201 (-3.3A)
19S  A1201 (-3.5A)
None
19S  A1201 (-4.7A)
19S  A1201 ( 3.8A)
19S  A1201 (-4.5A)
19S  A1201 ( 4.1A)
 0.97A 4mxzA-4hviA:
24.8		 4mxzA-4hviA:
34.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 LEU A 273
ALA A 293
LYS A 295
VAL A 323
TYR A 340
GLY A 344
LEU A 393
ASP A 404
 0J9  A 601 (-4.0A)
0J9  A 601 (-3.3A)
0J9  A 601 ( 4.7A)
None
0J9  A 601 ( 4.7A)
0J9  A 601 ( 4.1A)
0J9  A 601 (-4.5A)
0J9  A 601 (-3.1A)
 0.82A 4mxzA-4k11A:
34.3		 4mxzA-4k11A:
94.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		9 LEU A 273
VAL A 281
ALA A 293
LYS A 295
VAL A 323
ILE A 336
TYR A 340
GLY A 344
LEU A 393
 0J9  A 601 (-4.0A)
0J9  A 601 (-4.4A)
0J9  A 601 (-3.3A)
0J9  A 601 ( 4.7A)
None
0J9  A 601 (-4.4A)
0J9  A 601 ( 4.7A)
0J9  A 601 ( 4.1A)
0J9  A 601 (-4.5A)
 0.59A 4mxzA-4k11A:
34.3		 4mxzA-4k11A:
94.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 478
VAL A 486
ALA A 506
LYS A 508
GLU A 525
TYR A 557
GLY A 561
LEU A 624
ASP A 635
 ACP  A 801 (-3.8A)
ACP  A 801 (-4.2A)
ACP  A 801 (-3.3A)
ACP  A 801 (-2.7A)
ACP  A 801 ( 4.8A)
None
ACP  A 801 ( 4.6A)
ACP  A 801 (-4.4A)
MG  A 802 ( 3.0A)
 0.92A 4mxzA-4k33A:
27.7		 4mxzA-4k33A:
35.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL A  50
ALA A  61
LYS A  63
GLU A  77
VAL A  90
TYR A 106
GLY A 110
LEU A 163
ASP A 175
 1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
None
None
None
1UL  A 501 (-4.1A)
1UL  A 501 ( 3.7A)
1UL  A 501 (-4.3A)
1UL  A 501 (-4.2A)
 0.98A 4mxzA-4l52A:
21.1		 4mxzA-4l52A:
31.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  33
ALA A  54
GLU A  70
VAL A  83
MET A  99
TYR A 101
GLY A 105
LEU A 153
 GOL  A 404 ( 3.6A)
GOL  A 404 ( 3.1A)
None
GOL  A 403 (-4.1A)
GOL  A 403 (-2.7A)
GOL  A 404 ( 4.9A)
GOL  A 404 (-3.6A)
GOL  A 403 ( 4.4A)
 0.90A 4mxzA-4lg4A:
20.8		 4mxzA-4lg4A:
28.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  33
ALA A  54
VAL A  83
ILE A  97
MET A  99
TYR A 101
GLY A 105
LEU A 153
 GOL  A 404 ( 3.6A)
GOL  A 404 ( 3.1A)
GOL  A 403 (-4.1A)
None
GOL  A 403 (-2.7A)
GOL  A 404 ( 4.9A)
GOL  A 404 (-3.6A)
GOL  A 403 ( 4.4A)
 0.76A 4mxzA-4lg4A:
20.8		 4mxzA-4lg4A:
28.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  33
VAL A  41
ALA A  54
GLU A  70
VAL A  83
TYR A 101
GLY A 105
LEU A 153
 GOL  A 404 ( 3.6A)
GOL  A 404 (-4.5A)
GOL  A 404 ( 3.1A)
None
GOL  A 403 (-4.1A)
GOL  A 404 ( 4.9A)
GOL  A 404 (-3.6A)
GOL  A 403 ( 4.4A)
 0.82A 4mxzA-4lg4A:
20.8		 4mxzA-4lg4A:
28.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  33
VAL A  41
ALA A  54
VAL A  83
ILE A  97
TYR A 101
GLY A 105
LEU A 153
 GOL  A 404 ( 3.6A)
GOL  A 404 (-4.5A)
GOL  A 404 ( 3.1A)
GOL  A 403 (-4.1A)
None
GOL  A 404 ( 4.9A)
GOL  A 404 (-3.6A)
GOL  A 403 ( 4.4A)
 0.67A 4mxzA-4lg4A:
20.8		 4mxzA-4lg4A:
28.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		8 LEU A 273
VAL A 281
ALA A 293
GLU A 310
VAL A 323
ILE A 336
TYR A 340
ASP A 404
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 4.3A)
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 4.7A)
 0.76A 4mxzA-4lggA:
37.6		 4mxzA-4lggA:
98.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		9 LEU A 273
VAL A 281
ALA A 293
GLU A 310
VAL A 323
ILE A 336
TYR A 340
GLY A 344
LEU A 393
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 4.3A)
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
 0.63A 4mxzA-4lggA:
37.6		 4mxzA-4lggA:
98.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		8 ALA B  51
GLU B  70
ILE B  97
MET B  99
TYR B 101
GLY B 105
LEU B 151
ASP B 162
 ADP  B 500 (-3.3A)
None
None
ADP  B 500 ( 4.1A)
ADP  B 500 ( 4.7A)
None
ADP  B 500 (-4.7A)
ADP  B 500 ( 3.4A)
 0.87A 4mxzA-4o27B:
22.9		 4mxzA-4o27B:
31.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL B  38
ALA B  51
GLU B  70
ILE B  97
TYR B 101
GLY B 105
LEU B 151
ASP B 162
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
None
None
ADP  B 500 ( 4.7A)
None
ADP  B 500 (-4.7A)
ADP  B 500 ( 3.4A)
 0.87A 4mxzA-4o27B:
22.9		 4mxzA-4o27B:
31.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL B  38
ALA B  51
LYS B  53
GLU B  70
ILE B  97
TYR B 101
LEU B 151
ASP B 162
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
None
ADP  B 500 ( 4.7A)
ADP  B 500 (-4.7A)
ADP  B 500 ( 3.4A)
 0.89A 4mxzA-4o27B:
22.9		 4mxzA-4o27B:
31.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  46
VAL A  54
ALA A  67
GLU A  85
VAL A  99
GLY A 128
LEU A 180
ASP A 191
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
None
 0.95A 4mxzA-4o38A:
21.4		 4mxzA-4o38A:
26.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otd SERINE/THREONINE-PRO
TEIN KINASE N1

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		9 LEU A 627
VAL A 635
ALA A 648
LYS A 650
VAL A 685
MET A 701
TYR A 703
GLY A 707
ASP A 764
 None
 0.89A 4mxzA-4otdA:
23.3		 4mxzA-4otdA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otd SERINE/THREONINE-PRO
TEIN KINASE N1

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		9 LEU A 627
VAL A 635
ALA A 648
LYS A 650
VAL A 685
TYR A 703
GLY A 707
LEU A 753
ASP A 764
 None
 0.94A 4mxzA-4otdA:
23.3		 4mxzA-4otdA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9z HUMAN PROTEIN KINASE
C THETA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		8 LEU A 386
VAL A 394
ALA A 407
GLU A 428
MET A 458
TYR A 460
LEU A 511
ASP A 522
 PZW  A 801 (-3.9A)
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
PZW  A 801 (-4.4A)
None
PZW  A 801 (-4.8A)
PZW  A 801 (-3.2A)
 0.86A 4mxzA-4q9zA:
22.6		 4mxzA-4q9zA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9z HUMAN PROTEIN KINASE
C THETA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		8 LEU A 386
VAL A 394
ALA A 407
LYS A 409
MET A 458
TYR A 460
LEU A 511
ASP A 522
 PZW  A 801 (-3.9A)
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
PZW  A 801 (-4.4A)
None
PZW  A 801 (-4.8A)
PZW  A 801 (-3.2A)
 0.91A 4mxzA-4q9zA:
22.6		 4mxzA-4q9zA:
25.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		10 LEU A  14
VAL A  22
ALA A  35
GLU A  52
VAL A  65
ILE A  79
TYR A  83
GLY A  87
LEU A 136
ASP A 147
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 ( 4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
 0.67A 4mxzA-4ueuA:
36.1		 4mxzA-4ueuA:
61.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		9 LEU A  14
VAL A  22
LYS A  37
GLU A  52
ILE A  79
TYR A  83
GLY A  87
LEU A 136
ASP A 147
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
None
None
None
ACP  A1264 ( 4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
 0.77A 4mxzA-4ueuA:
36.1		 4mxzA-4ueuA:
61.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		8 LEU A 104
VAL A 112
ALA A 125
LYS A 127
VAL A 159
TYR A 177
LEU A 228
ASP A 239
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
None
None
ATP  A 501 (-4.5A)
ZN  A 503 (-1.9A)
 0.96A 4mxzA-4wb7A:
23.3		 4mxzA-4wb7A:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		8 LEU A 193
VAL A 201
ALA A 214
GLU A 235
VAL A 248
GLY A 270
LEU A 321
ASP A 332
 ANW  A 601 ( 4.0A)
None
ANW  A 601 (-3.4A)
None
None
ANW  A 601 ( 4.5A)
ANW  A 601 (-4.9A)
None
 0.85A 4mxzA-4wboA:
24.6		 4mxzA-4wboA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  52
VAL A  60
ALA A  72
VAL A 104
ILE A 124
GLY A 132
LEU A 183
ASP A 194
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
None
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
ZN  A 403 ( 2.6A)
 0.82A 4mxzA-4wsqA:
12.4		 4mxzA-4wsqA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 LEU A 408
VAL A 416
ALA A 428
VAL A 458
ILE A 472
TYR A 476
GLY A 480
LEU A 528
 None
 0.62A 4mxzA-4xi2A:
26.4		 4mxzA-4xi2A:
27.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 616
VAL A 624
ALA A 642
LYS A 644
GLU A 661
VAL A 675
TYR A 693
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
None
P30  A1001 ( 4.4A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.93A 4mxzA-4xufA:
23.1		 4mxzA-4xufA:
37.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		8 LEU A 408
VAL A 416
ALA A 428
VAL A 458
ILE A 472
TYR A 476
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
None
None
746  A 702 (-4.4A)
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.51A 4mxzA-4y93A:
31.7		 4mxzA-4y93A:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		8 VAL A  70
ALA A  83
LYS A  85
VAL A 116
MET A 132
TYR A 134
GLY A 138
ASP A 196
 5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
5RC  A4000 (-2.8A)
None
5RC  A4000 ( 4.0A)
5RC  A4000 (-4.5A)
5RC  A4000 (-3.3A)
5RC  A4000 (-3.6A)
 0.90A 4mxzA-5es1A:
21.2		 4mxzA-5es1A:
28.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 599
VAL A 607
ALA A 625
LYS A 627
GLU A 644
ILE A 672
TYR A 676
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.9A)
748  A1001 (-4.0A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 1.06A 4mxzA-5grnA:
24.1		 4mxzA-5grnA:
33.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 607
ALA A 625
GLU A 644
VAL A 658
ILE A 672
TYR A 676
GLY A 680
LEU A 825
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 ( 4.8A)
748  A1001 (-3.9A)
748  A1001 (-4.0A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.99A 4mxzA-5grnA:
24.1		 4mxzA-5grnA:
33.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz8 PROTEIN O-MANNOSE
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		8 VAL A  94
ALA A 105
VAL A 134
ILE A 146
TYR A 150
GLY A 154
LEU A 215
ASP A 226
 None
 0.91A 4mxzA-5gz8A:
19.9		 4mxzA-5gz8A:
26.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		10 LEU A  57
VAL A  65
ALA A  77
LYS A  79
VAL A 109
ILE A 128
TYR A 132
GLY A 136
LEU A 187
ASP A 198
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
None
IDV  A 401 (-3.5A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
IDV  A 401 (-4.0A)
 0.79A 4mxzA-5i3oA:
23.6		 4mxzA-5i3oA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A  30
ALA A  43
LYS A  45
GLU A  61
VAL A  74
ILE A  88
GLY A  96
ASP A 154
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
None
6G2  A 901 (-3.6A)
6G2  A 901 (-3.4A)
 0.86A 4mxzA-5j5tA:
22.9		 4mxzA-5j5tA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A  30
ALA A  43
LYS A  45
VAL A  74
ILE A  88
GLY A  96
LEU A 143
ASP A 154
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 (-3.4A)
 0.69A 4mxzA-5j5tA:
22.9		 4mxzA-5j5tA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A 404
ALA A 417
GLU A 436
VAL A 449
MET A 465
GLY A 471
LEU A 518
ASP A 533
 GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
None
None
GUI  A 701 ( 4.1A)
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 4.8A)
 0.68A 4mxzA-5jznA:
25.3		 4mxzA-5jznA:
28.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A 284
ALA A 297
VAL A 328
MET A 344
TYR A 346
GLY A 350
LEU A 396
ASP A 407
 IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
None
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
IPW  A 601 ( 3.8A)
IPW  A 601 (-4.5A)
None
 0.62A 4mxzA-5kbrA:
24.4		 4mxzA-5kbrA:
27.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 209
ALA A 228
GLU A 250
ILE A 281
MET A 283
TYR A 285
GLY A 289
LEU A 338
 None
6UY  A 501 (-3.4A)
6UY  A 501 (-4.3A)
None
6UY  A 501 (-3.8A)
6UY  A 501 ( 4.8A)
6UY  A 501 ( 4.3A)
6UY  A 501 (-4.5A)
 0.85A 4mxzA-5ko1A:
27.5		 4mxzA-5ko1A:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 209
ALA A 228
LYS A 230
ILE A 281
MET A 283
TYR A 285
GLY A 289
LEU A 338
 None
6UY  A 501 (-3.4A)
6UY  A 501 (-4.0A)
None
6UY  A 501 (-3.8A)
6UY  A 501 ( 4.8A)
6UY  A 501 ( 4.3A)
6UY  A 501 (-4.5A)
 0.75A 4mxzA-5ko1A:
27.5		 4mxzA-5ko1A:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		8 ALA A 119
GLU A 140
VAL A 153
MET A 169
TYR A 171
GLY A 175
LEU A 221
ASP A 232
 None
 0.74A 4mxzA-5u7qA:
21.4		 4mxzA-5u7qA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A 106
ALA A 119
GLU A 140
VAL A 153
TYR A 171
GLY A 175
LEU A 221
ASP A 232
 None
 0.75A 4mxzA-5u7qA:
21.4		 4mxzA-5u7qA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A 106
ALA A 119
LYS A 121
GLU A 140
TYR A 171
GLY A 175
LEU A 221
ASP A 232
 None
 0.89A 4mxzA-5u7qA:
21.4		 4mxzA-5u7qA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis) 		no annotation 8 LEU A  17
VAL A  25
ALA A  38
GLU A  59
VAL A  72
ILE A  90
TYR A  94
ASP A 156
 G93  A 301 ( 3.8A)
G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
G93  A 301 (-3.2A)
G93  A 301 (-4.0A)
G93  A 301 ( 3.8A)
None
G93  A 301 ( 3.2A)
 0.95A 4mxzA-5u94A:
20.3		 4mxzA-5u94A:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		no annotation 8 ALA A 707
GLU A 725
VAL A 738
ILE A 752
MET A 754
GLY A 760
LEU A 810
ASP A 822
 9E1  A1001 (-3.5A)
None
9E1  A1001 (-4.1A)
None
9E1  A1001 (-2.8A)
9E1  A1001 (-3.4A)
9E1  A1001 (-4.5A)
9E1  A1001 (-3.6A)
 0.91A 4mxzA-5vilA:
22.9		 4mxzA-5vilA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 8 LEU A  33
VAL A  41
ALA A  54
VAL A  83
ILE A  97
TYR A 101
GLY A 105
LEU A 153
 ANP  A 501 ( 3.8A)
ANP  A 501 (-4.4A)
ANP  A 501 ( 3.7A)
None
None
ANP  A 501 ( 4.2A)
ANP  A 501 ( 4.0A)
ANP  A 501 (-4.6A)
 0.44A 4mxzA-6ao5A:
23.2		 4mxzA-6ao5A:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 8 LEU A 881
VAL A 889
ALA A 906
GLU A 925
VAL A 938
GLY A 962
LEU A1010
ASP A1021
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
None
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
MG  A1203 (-1.8A)
 0.80A 4mxzA-6c7yA:
30.2		 4mxzA-6c7yA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 8 LEU A 881
VAL A 889
ALA A 906
LYS A 908
VAL A 938
GLY A 962
LEU A1010
ASP A1021
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
MG  A1203 (-1.8A)
 0.78A 4mxzA-6c7yA:
30.2		 4mxzA-6c7yA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cth CONCANAVALIN A-LIKE
LECTIN PROTEIN
KINASE FAMILY
PROTEIN

(Theobroma cacao) 		no annotation 8 LEU A 275
VAL A 283
ALA A 296
LYS A 298
GLU A 314
VAL A 327
GLY A 349
ASP A 411
 FE7  A 601 (-3.8A)
FE7  A 601 ( 4.3A)
FE7  A 601 (-3.3A)
FE7  A 601 (-3.6A)
None
None
FE7  A 601 ( 3.7A)
MG  A 602 ( 2.6A)
 0.90A 4mxzA-6cthA:
23.4		 4mxzA-6cthA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4

(Homo sapiens) 		no annotation 8 VAL A 200
ALA A 211
GLU A 233
VAL A 246
TYR A 264
GLY A 268
LEU A 318
ASP A 329
 CJT  A 502 ( 4.8A)
CJT  A 502 (-3.4A)
CJT  A 502 (-3.9A)
None
CJT  A 502 (-4.5A)
CJT  A 502 ( 4.3A)
CJT  A 502 (-4.7A)
CJT  A 502 ( 4.0A)
 0.66A 4mxzA-6f3dA:
25.7		 4mxzA-6f3dA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4

(Homo sapiens) 		no annotation 8 VAL A 200
ALA A 211
LYS A 213
VAL A 246
TYR A 264
GLY A 268
LEU A 318
ASP A 329
 CJT  A 502 ( 4.8A)
CJT  A 502 (-3.4A)
CJT  A 502 (-3.0A)
None
CJT  A 502 (-4.5A)
CJT  A 502 ( 4.3A)
CJT  A 502 (-4.7A)
CJT  A 502 ( 4.0A)
 0.62A 4mxzA-6f3dA:
25.7		 4mxzA-6f3dA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdy -

(-) 		no annotation 9 LEU U  20
VAL U  28
ALA U  42
LYS U  44
VAL U  75
MET U  91
GLY U  97
LEU U 144
ASP U 157
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.0A)
DB8  U 301 (-4.8A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.8A)
DB8  U 301 (-3.6A)
 0.79A 4mxzA-6fdyU:
23.5		 4mxzA-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1

(Homo sapiens) 		no annotation 8 LEU A 167
VAL A 175
ALA A 189
LYS A 191
GLU A 206
ILE A 239
LEU A 295
ASP A 325
 EAQ  A 501 (-3.9A)
None
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.2A)
EAQ  A 501 (-3.4A)
None
EAQ  A 501 (-4.9A)
EAQ  A 501 (-4.6A)
 0.81A 4mxzA-6fyoA:
24.4		 4mxzA-6fyoA:
undetectable