SIMILAR PATTERNS OF AMINO ACIDS FOR 4MXY_B_DB8B601

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE


(Rattus
norvegicus)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
7 VAL A 209
ALA A 220
VAL A 249
TYR A 268
GLY A 272
LEU A 321
ASP A 332
None
0.59A 4mxyB-1k9aA:
32.9
4mxyB-1k9aA:
29.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK


(Rattus
norvegicus)
PF07714
(Pkinase_Tyr)
9 VAL A 588
ALA A 606
LYS A 608
VAL A 638
TYR A 656
GLY A 660
LEU A 731
ALA A 741
ASP A 742
None
0.86A 4mxyB-1lufA:
25.7
4mxyB-1lufA:
33.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1


(Mus musculus)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
8 LEU A 267
VAL A 275
ALA A 288
LYS A 290
VAL A 318
GLY A 340
LEU A 389
ALA A 399
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 ( 4.7A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.96A 4mxyB-1opkA:
32.1
4mxyB-1opkA:
29.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1


(Homo sapiens)
PF00069
(Pkinase)
8 LEU A  15
VAL A  23
ALA A  36
LYS A  38
TYR A  86
GLY A  90
LEU A 137
ASP A 148
HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
HYM  A 400 (-4.7A)
None
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
0.96A 4mxyB-1zltA:
22.8
4mxyB-1zltA:
26.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 LEU X  17
VAL X  25
ALA X  37
GLU X  54
VAL X  67
TYR X  84
ALA X 147
ASP X 148
STU  X 902 (-3.8A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
STU  X 902 (-4.6A)
STU  X 902 ( 4.1A)
STU  X 902 (-3.6A)
0.90A 4mxyB-2dq7X:
37.5
4mxyB-2dq7X:
83.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN


(Homo sapiens)
PF07714
(Pkinase_Tyr)
10 LEU X  17
VAL X  25
ALA X  37
LYS X  39
VAL X  67
TYR X  84
GLY X  88
LEU X 137
ALA X 147
ASP X 148
STU  X 902 (-3.8A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
None
STU  X 902 (-4.6A)
STU  X 902 (-3.5A)
STU  X 902 (-4.4A)
STU  X 902 ( 4.1A)
STU  X 902 (-3.6A)
0.84A 4mxyB-2dq7X:
37.5
4mxyB-2dq7X:
83.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC


(Homo sapiens)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
9 LEU A 273
VAL A 281
ALA A 293
LYS A 295
VAL A 323
TYR A 340
GLY A 344
LEU A 393
ASP A 404
H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
None
H8H  A 534 (-4.3A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 (-4.2A)
0.74A 4mxyB-2h8hA:
34.1
4mxyB-2h8hA:
52.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC


(Homo sapiens)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
9 LEU A 273
VAL A 281
ALA A 293
VAL A 323
TYR A 340
GLY A 344
LEU A 393
ALA A 403
ASP A 404
H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
None
H8H  A 534 (-4.3A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
H8H  A 534 (-4.2A)
0.57A 4mxyB-2h8hA:
34.1
4mxyB-2h8hA:
52.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hck HEMATOPOETIC CELL
KINASE HCK


(Homo sapiens)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
8 LEU A 273
VAL A 281
ALA A 293
LYS A 295
VAL A 323
GLY A 344
LEU A 393
ALA A 403
QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
0.76A 4mxyB-2hckA:
32.8
4mxyB-2hckA:
50.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
9 LEU A 251
VAL A 259
ALA A 271
GLU A 288
VAL A 301
GLY A 322
LEU A 371
ALA A 381
ASP A 382
1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
None
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
0.62A 4mxyB-2hk5A:
28.6
4mxyB-2hk5A:
66.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 LEU A 251
VAL A 259
ALA A 271
LYS A 273
TYR A 318
GLY A 322
LEU A 371
ALA A 381
None
None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.7A)
1N8  A 501 ( 3.5A)
1N8  A 501 ( 4.3A)
1N8  A 501 ( 3.3A)
0.94A 4mxyB-2og8A:
27.6
4mxyB-2og8A:
66.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 LEU A 251
VAL A 259
ALA A 271
VAL A 301
TYR A 318
GLY A 322
LEU A 371
ALA A 381
None
None
1N8  A 501 ( 3.4A)
None
1N8  A 501 ( 3.7A)
1N8  A 501 ( 3.5A)
1N8  A 501 ( 4.3A)
1N8  A 501 ( 3.3A)
0.88A 4mxyB-2og8A:
27.6
4mxyB-2og8A:
66.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 LEU A 588
VAL A 596
ALA A 614
VAL A 647
TYR A 665
GLY A 669
LEU A 785
ASP A 796
None
0.88A 4mxyB-2ogvA:
21.4
4mxyB-2ogvA:
34.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 LEU A 487
VAL A 495
ALA A 515
TYR A 566
GLY A 570
LEU A 633
ALA A 643
None
0.66A 4mxyB-2psqA:
27.6
4mxyB-2psqA:
31.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qkw PROTEIN KINASE

(Solanum
pimpinellifolium)
PF07714
(Pkinase_Tyr)
8 VAL B  55
ALA B  67
GLU B  85
VAL B  98
TYR B 116
GLY B 120
LEU B 171
ASP B 182
None
0.69A 4mxyB-2qkwB:
20.6
4mxyB-2qkwB:
30.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5


(Homo sapiens)
PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM)
7 VAL A 689
ALA A 705
GLU A 724
TYR A 755
GLY A 759
LEU A 807
ASP A 818
None
0.60A 4mxyB-2r2pA:
30.2
4mxyB-2r2pA:
42.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd5 DMPK PROTEIN

(Homo sapiens)
PF00069
(Pkinase)
8 VAL A  85
ALA A  98
LYS A 100
MET A 148
TYR A 150
LEU A 202
ALA A 212
ASP A 213
BI8  A1417 ( 4.7A)
BI8  A1417 ( 3.8A)
BI8  A1417 (-4.2A)
BI8  A1417 (-4.1A)
BI8  A1417 (-4.8A)
BI8  A1417 (-4.8A)
BI8  A1417 ( 4.1A)
BI8  A1417 (-3.8A)
0.77A 4mxyB-2vd5A:
22.0
4mxyB-2vd5A:
26.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xik SERINE/THREONINE
PROTEIN KINASE 25


(Homo sapiens)
PF00069
(Pkinase)
8 ALA A  47
LYS A  49
MET A  95
TYR A  97
GLY A 101
LEU A 147
ALA A 157
ASP A 158
J60  A1294 (-3.3A)
None
J60  A1294 ( 3.8A)
J60  A1294 (-4.5A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
J60  A1294 ( 4.6A)
0.64A 4mxyB-2xikA:
20.5
4mxyB-2xikA:
30.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xik SERINE/THREONINE
PROTEIN KINASE 25


(Homo sapiens)
PF00069
(Pkinase)
8 VAL A  34
ALA A  47
LYS A  49
TYR A  97
GLY A 101
LEU A 147
ALA A 157
ASP A 158
J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
J60  A1294 (-4.5A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
J60  A1294 ( 4.6A)
0.71A 4mxyB-2xikA:
20.5
4mxyB-2xikA:
30.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN


(Mus musculus)
PF07714
(Pkinase_Tyr)
9 LEU A 253
VAL A 261
ALA A 273
GLU A 290
VAL A 303
GLY A 325
LEU A 374
ALA A 384
ASP A 385
None
0.57A 4mxyB-2zv7A:
37.7
4mxyB-2zv7A:
63.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 LEU A 487
VAL A 495
ALA A 515
GLU A 534
TYR A 566
GLY A 570
LEU A 633
ALA A 643
M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
M33  A1996 ( 4.7A)
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
None
0.72A 4mxyB-3b2tA:
28.4
4mxyB-3b2tA:
36.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 VAL A 495
ALA A 515
LYS A 517
GLU A 534
TYR A 566
GLY A 570
LEU A 633
ALA A 643
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
None
M33  A1996 ( 4.7A)
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
None
0.78A 4mxyB-3b2tA:
28.4
4mxyB-3b2tA:
36.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
9 LEU A 484
VAL A 492
ALA A 512
LYS A 514
TYR A 563
GLY A 567
LEU A 630
ALA A 640
ASP A 641
C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
None
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
C4F  A   1 (-4.5A)
0.92A 4mxyB-3c4fA:
29.8
4mxyB-3c4fA:
36.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 VAL A 209
ALA A 220
VAL A 249
TYR A 268
GLY A 272
LEU A 321
ASP A 332
None
0.59A 4mxyB-3d7uA:
27.2
4mxyB-3d7uA:
40.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2


(Homo sapiens)
PF00069
(Pkinase)
7 VAL A 217
ALA A 228
GLU A 243
TYR A 281
GLY A 285
LEU A 340
ASP A 351
ADP  A 900 (-4.3A)
ADP  A 900 (-3.4A)
ADP  A 900 ( 4.7A)
None
ADP  A 900 ( 4.2A)
ADP  A 900 (-4.6A)
ADP  A 900 ( 2.7A)
0.63A 4mxyB-3g2fA:
20.7
4mxyB-3g2fA:
26.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2


(Homo sapiens)
PF00069
(Pkinase)
PF00627
(UBA)
9 VAL A  67
ALA A  80
LYS A  82
VAL A 113
TYR A 131
GLY A 135
LEU A 182
ALA A 192
ASP A 193
None
0.91A 4mxyB-3iecA:
24.6
4mxyB-3iecA:
27.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2


(Homo sapiens)
PF00069
(Pkinase)
PF00627
(UBA)
9 VAL A  67
ALA A  80
VAL A 113
MET A 129
TYR A 131
GLY A 135
LEU A 182
ALA A 192
ASP A 193
None
0.89A 4mxyB-3iecA:
24.6
4mxyB-3iecA:
27.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kex RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 LEU A 696
VAL A 704
VAL A 753
TYR A 770
GLY A 774
LEU A 822
ALA A 832
ANP  A   1 (-4.4A)
ANP  A   1 (-3.9A)
None
ANP  A   1 (-4.3A)
ANP  A   1 ( 4.9A)
ANP  A   1 (-4.7A)
None
0.67A 4mxyB-3kexA:
26.5
4mxyB-3kexA:
32.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 VAL A 216
ALA A 227
GLU A 242
TYR A 279
GLY A 283
LEU A 337
ALA A 347
ASP A 348
LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
None
LDN  A 600 (-4.7A)
LDN  A 600 (-3.3A)
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
None
0.77A 4mxyB-3my0A:
26.8
4mxyB-3my0A:
27.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 VAL A 216
ALA A 227
LYS A 229
GLU A 242
TYR A 279
GLY A 283
LEU A 337
ASP A 348
LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
None
LDN  A 600 (-4.7A)
LDN  A 600 (-3.3A)
LDN  A 600 (-4.6A)
None
0.87A 4mxyB-3my0A:
26.8
4mxyB-3my0A:
27.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens)
PF00069
(Pkinase)
8 LEU A  88
VAL A  96
ALA A 109
LYS A 111
TYR A 161
GLY A 165
LEU A 212
ASP A 223
JOZ  A 361 (-4.1A)
JOZ  A 361 ( 4.7A)
JOZ  A 361 (-3.4A)
SO4  A   5 (-2.8A)
None
None
None
SO4  A   5 ( 4.5A)
0.96A 4mxyB-3nuuA:
25.2
4mxyB-3nuuA:
25.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1


(Arabidopsis
thaliana)
PF07714
(Pkinase_Tyr)
8 VAL A 565
ALA A 576
LYS A 578
VAL A 609
TYR A 627
GLY A 631
LEU A 683
ASP A 694
STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
STU  A   1 (-4.4A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
0.66A 4mxyB-3ppzA:
31.1
4mxyB-3ppzA:
32.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v5q NT-3 GROWTH FACTOR
RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 LEU A 544
VAL A 552
ALA A 570
LYS A 572
VAL A 601
TYR A 619
GLY A 623
LEU A 686
0F4  A 902 ( 4.2A)
None
0F4  A 902 (-3.2A)
0F4  A 902 (-4.0A)
None
0F4  A 902 (-4.2A)
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
0.74A 4mxyB-3v5qA:
24.9
4mxyB-3v5qA:
35.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w18 AURORA KINASE A

(Homo sapiens)
PF00069
(Pkinase)
8 LEU A 139
VAL A 147
ALA A 160
LYS A 162
TYR A 212
GLY A 216
LEU A 263
ALA A 273
N13  A 501 (-3.7A)
N13  A 501 ( 4.7A)
N13  A 501 ( 4.1A)
N13  A 501 (-2.9A)
N13  A 501 (-4.4A)
N13  A 501 (-3.5A)
N13  A 501 (-4.5A)
N13  A 501 ( 3.8A)
0.91A 4mxyB-3w18A:
22.5
4mxyB-3w18A:
24.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 LEU A 840
VAL A 848
ALA A 866
LYS A 868
VAL A 899
GLY A 922
LEU A1035
ASP A1046
LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
None
None
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
GOL  A1210 ( 3.4A)
0.75A 4mxyB-3wzdA:
30.4
4mxyB-3wzdA:
35.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 LEU A1951
VAL A1959
ALA A1978
LYS A1980
GLY A2032
LEU A2086
ASP A2102
VGH  A3000 ( 4.4A)
None
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
None
0.52A 4mxyB-3zbfA:
28.2
4mxyB-3zbfA:
40.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 LEU A 560
VAL A 568
ALA A 586
LYS A 588
VAL A 617
TYR A 635
GLY A 639
LEU A 699
LTI  A1839 ( 4.2A)
None
LTI  A1839 (-3.3A)
None
None
LTI  A1839 (-4.7A)
LTI  A1839 (-3.4A)
LTI  A1839 (-4.2A)
0.68A 4mxyB-4at3A:
29.5
4mxyB-4at3A:
34.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 LEU A 560
VAL A 568
ALA A 586
VAL A 617
TYR A 635
GLY A 639
LEU A 699
ASP A 710
LTI  A1839 ( 4.2A)
None
LTI  A1839 (-3.3A)
None
LTI  A1839 (-4.7A)
LTI  A1839 (-3.4A)
LTI  A1839 (-4.2A)
None
0.68A 4mxyB-4at3A:
29.5
4mxyB-4at3A:
34.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA


(Rattus
norvegicus)
PF00069
(Pkinase)
PF00433
(Pkinase_C)
8 VAL A  91
ALA A 104
LYS A 106
TYR A 156
GLY A 160
LEU A 208
ALA A 218
ASP A 219
None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
EDO  A1420 (-4.9A)
None
EDO  A1420 ( 4.8A)
None
None
1.06A 4mxyB-4aw2A:
16.5
4mxyB-4aw2A:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10


(Homo sapiens)
PF00069
(Pkinase)
8 LEU A  42
VAL A  50
ALA A  63
LYS A  65
VAL A  94
GLY A 116
LEU A 164
ALA A 174
XZN  A1317 (-3.6A)
XZN  A1317 ( 4.7A)
XZN  A1317 (-3.5A)
XZN  A1317 (-4.1A)
XZN  A1317 (-4.4A)
XZN  A1317 ( 3.7A)
XZN  A1317 (-4.7A)
XZN  A1317 ( 4.3A)
0.80A 4mxyB-4bc6A:
22.8
4mxyB-4bc6A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE


(Candida
albicans)
PF00069
(Pkinase)
8 LEU A 246
VAL A 254
ALA A 267
LYS A 269
TYR A 320
GLY A 324
LEU A 371
ASP A 382
None
0.97A 4mxyB-4c0tA:
24.0
4mxyB-4c0tA:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1


(Rattus
norvegicus)
PF00069
(Pkinase)
PF16579
(AdenylateSensor)
8 LEU A  22
VAL A  30
ALA A  43
LYS A  45
TYR A  95
GLY A  99
LEU A 146
ASP A 157
STU  A1550 (-4.3A)
None
STU  A1550 (-3.1A)
STU  A1550 (-3.6A)
STU  A1550 (-4.5A)
STU  A1550 (-3.4A)
STU  A1550 (-4.3A)
STU  A1550 (-3.6A)
0.99A 4mxyB-4cfhA:
24.6
4mxyB-4cfhA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1


(Rattus
norvegicus)
PF00069
(Pkinase)
PF16579
(AdenylateSensor)
8 VAL A  30
ALA A  43
LYS A  45
TYR A  95
GLY A  99
LEU A 146
ALA A 156
ASP A 157
None
STU  A1550 (-3.1A)
STU  A1550 (-3.6A)
STU  A1550 (-4.5A)
STU  A1550 (-3.4A)
STU  A1550 (-4.3A)
STU  A1550 ( 3.8A)
STU  A1550 (-3.6A)
0.96A 4mxyB-4cfhA:
24.6
4mxyB-4cfhA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2


(Homo sapiens)
PF00069
(Pkinase)
PF00433
(Pkinase_C)
8 ALA A 684
VAL A 721
MET A 737
TYR A 739
GLY A 743
LEU A 789
ALA A 799
ASP A 800
AGS  A1985 (-3.5A)
None
AGS  A1985 (-4.2A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
AGS  A1985 ( 3.3A)
0.83A 4mxyB-4crsA:
22.6
4mxyB-4crsA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2


(Homo sapiens)
PF00069
(Pkinase)
PF00433
(Pkinase_C)
8 LEU A 663
VAL A 671
ALA A 684
LYS A 686
TYR A 739
GLY A 743
LEU A 789
ASP A 800
AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
0.89A 4mxyB-4crsA:
22.6
4mxyB-4crsA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2


(Homo sapiens)
PF00069
(Pkinase)
PF00433
(Pkinase_C)
9 LEU A 663
VAL A 671
ALA A 684
VAL A 721
TYR A 739
GLY A 743
LEU A 789
ALA A 799
ASP A 800
AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
AGS  A1985 ( 3.3A)
0.80A 4mxyB-4crsA:
22.6
4mxyB-4crsA:
25.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS


(Homo sapiens)
PF00017
(SH2)
PF07714
(Pkinase_Tyr)
8 VAL A 575
ALA A 588
GLU A 607
VAL A 620
MET A 636
GLY A 642
LEU A 690
ASP A 701
GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
None
None
GUI  A 901 ( 4.8A)
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
0.51A 4mxyB-4e93A:
28.5
4mxyB-4e93A:
33.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 LEU A 515
VAL A 523
ALA A 541
LYS A 543
VAL A 572
GLY A 594
LEU A 656
None
0.59A 4mxyB-4f0iA:
30.1
4mxyB-4f0iA:
34.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 LEU A 515
VAL A 523
ALA A 541
VAL A 572
TYR A 590
GLY A 594
LEU A 656
ASP A 667
None
0.72A 4mxyB-4f0iA:
30.1
4mxyB-4f0iA:
34.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f4p TYROSINE-PROTEIN
KINASE SYK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
9 LEU A 377
VAL A 385
ALA A 400
GLU A 420
VAL A 433
MET A 448
GLY A 454
LEU A 501
ASP A 512
0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
None
None
0SB  A 701 (-3.6A)
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
0SB  A 701 (-3.9A)
0.77A 4mxyB-4f4pA:
27.9
4mxyB-4f4pA:
36.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fod ALK TYROSINE KINASE
RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 LEU A1122
VAL A1130
ALA A1148
VAL A1180
GLY A1202
LEU A1256
ASP A1270
0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 ( 4.9A)
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
0UV  A1501 ( 4.2A)
0.50A 4mxyB-4fodA:
24.6
4mxyB-4fodA:
34.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 ALA A 853
VAL A 884
MET A 902
TYR A 904
GLY A 908
LEU A 956
ALA A 966
ASP A 967
19S  A1201 (-3.3A)
None
19S  A1201 (-3.6A)
19S  A1201 (-4.7A)
19S  A1201 ( 3.8A)
19S  A1201 (-4.5A)
19S  A1201 ( 4.1A)
19S  A1201 ( 4.1A)
0.72A 4mxyB-4hviA:
24.9
4mxyB-4hviA:
34.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
9 LEU A 828
ALA A 853
LYS A 855
VAL A 884
TYR A 904
GLY A 908
LEU A 956
ALA A 966
ASP A 967
19S  A1201 (-3.9A)
19S  A1201 (-3.3A)
19S  A1201 (-3.5A)
None
19S  A1201 (-4.7A)
19S  A1201 ( 3.8A)
19S  A1201 (-4.5A)
19S  A1201 ( 4.1A)
19S  A1201 ( 4.1A)
0.87A 4mxyB-4hviA:
24.9
4mxyB-4hviA:
34.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
9 LEU A 828
VAL A 836
ALA A 853
LYS A 855
TYR A 904
GLY A 908
LEU A 956
ALA A 966
ASP A 967
19S  A1201 (-3.9A)
19S  A1201 (-4.4A)
19S  A1201 (-3.3A)
19S  A1201 (-3.5A)
19S  A1201 (-4.7A)
19S  A1201 ( 3.8A)
19S  A1201 (-4.5A)
19S  A1201 ( 4.1A)
19S  A1201 ( 4.1A)
0.91A 4mxyB-4hviA:
24.9
4mxyB-4hviA:
34.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC


(Homo sapiens)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
7 LEU A 273
ALA A 293
TYR A 340
GLY A 344
LEU A 393
ALA A 403
ASP A 404
0J9  A 601 (-4.0A)
0J9  A 601 (-3.3A)
0J9  A 601 ( 4.7A)
0J9  A 601 ( 4.1A)
0J9  A 601 (-4.5A)
0J9  A 601 (-3.5A)
0J9  A 601 (-3.1A)
0.66A 4mxyB-4k11A:
33.7
4mxyB-4k11A:
94.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC


(Homo sapiens)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
8 LEU A 273
VAL A 281
ALA A 293
LYS A 295
VAL A 323
TYR A 340
GLY A 344
LEU A 393
0J9  A 601 (-4.0A)
0J9  A 601 (-4.4A)
0J9  A 601 (-3.3A)
0J9  A 601 ( 4.7A)
None
0J9  A 601 ( 4.7A)
0J9  A 601 ( 4.1A)
0J9  A 601 (-4.5A)
0.67A 4mxyB-4k11A:
33.7
4mxyB-4k11A:
94.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC


(Homo sapiens)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
8 LEU A 273
VAL A 281
ALA A 293
VAL A 323
TYR A 340
GLY A 344
LEU A 393
ALA A 403
0J9  A 601 (-4.0A)
0J9  A 601 (-4.4A)
0J9  A 601 (-3.3A)
None
0J9  A 601 ( 4.7A)
0J9  A 601 ( 4.1A)
0J9  A 601 (-4.5A)
0J9  A 601 (-3.5A)
0.56A 4mxyB-4k11A:
33.7
4mxyB-4k11A:
94.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 LEU A 478
VAL A 486
ALA A 506
LYS A 508
TYR A 557
GLY A 561
LEU A 624
ASP A 635
ACP  A 801 (-3.8A)
ACP  A 801 (-4.2A)
ACP  A 801 (-3.3A)
ACP  A 801 (-2.7A)
None
ACP  A 801 ( 4.6A)
ACP  A 801 (-4.4A)
MG  A 802 ( 3.0A)
0.79A 4mxyB-4k33A:
27.5
4mxyB-4k33A:
35.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 LEU A 478
VAL A 486
ALA A 506
TYR A 557
GLY A 561
LEU A 624
ALA A 634
ASP A 635
ACP  A 801 (-3.8A)
ACP  A 801 (-4.2A)
ACP  A 801 (-3.3A)
None
ACP  A 801 ( 4.6A)
ACP  A 801 (-4.4A)
None
MG  A 802 ( 3.0A)
0.73A 4mxyB-4k33A:
27.5
4mxyB-4k33A:
35.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3


(Homo sapiens)
PF00069
(Pkinase)
8 LEU A  33
VAL A  41
ALA A  54
LYS A  56
TYR A 101
GLY A 105
LEU A 153
ALA A 163
GOL  A 404 ( 3.6A)
GOL  A 404 (-4.5A)
GOL  A 404 ( 3.1A)
GOL  A 403 ( 4.6A)
GOL  A 404 ( 4.9A)
GOL  A 404 (-3.6A)
GOL  A 403 ( 4.4A)
GOL  A 403 ( 3.0A)
0.72A 4mxyB-4lg4A:
21.0
4mxyB-4lg4A:
28.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3


(Homo sapiens)
PF00069
(Pkinase)
8 LEU A  33
VAL A  41
ALA A  54
VAL A  83
TYR A 101
GLY A 105
LEU A 153
ALA A 163
GOL  A 404 ( 3.6A)
GOL  A 404 (-4.5A)
GOL  A 404 ( 3.1A)
GOL  A 403 (-4.1A)
GOL  A 404 ( 4.9A)
GOL  A 404 (-3.6A)
GOL  A 403 ( 4.4A)
GOL  A 403 ( 3.0A)
0.58A 4mxyB-4lg4A:
21.0
4mxyB-4lg4A:
28.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC


(Gallus gallus)
PF07714
(Pkinase_Tyr)
9 LEU A 273
VAL A 281
ALA A 293
GLU A 310
VAL A 323
TYR A 340
GLY A 344
ALA A 403
ASP A 404
VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 4.3A)
VGG  A 601 ( 4.8A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 3.2A)
VGG  A 601 ( 4.2A)
VGG  A 601 ( 4.7A)
0.60A 4mxyB-4lggA:
38.1
4mxyB-4lggA:
98.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC


(Gallus gallus)
PF07714
(Pkinase_Tyr)
9 LEU A 273
VAL A 281
ALA A 293
GLU A 310
VAL A 323
TYR A 340
GLY A 344
LEU A 393
ALA A 403
VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 4.3A)
VGG  A 601 ( 4.8A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.2A)
0.32A 4mxyB-4lggA:
38.1
4mxyB-4lggA:
98.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24


(Homo sapiens)
PF00069
(Pkinase)
8 VAL B  38
ALA B  51
LYS B  53
TYR B 101
GLY B 105
LEU B 151
ALA B 161
ASP B 162
ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
ADP  B 500 ( 4.7A)
None
ADP  B 500 (-4.7A)
None
ADP  B 500 ( 3.4A)
0.85A 4mxyB-4o27B:
23.1
4mxyB-4o27B:
31.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otd SERINE/THREONINE-PRO
TEIN KINASE N1


(Homo sapiens)
PF00069
(Pkinase)
PF00433
(Pkinase_C)
8 LEU A 627
VAL A 635
ALA A 648
LYS A 650
VAL A 685
TYR A 703
GLY A 707
LEU A 753
None
0.98A 4mxyB-4otdA:
23.1
4mxyB-4otdA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otd SERINE/THREONINE-PRO
TEIN KINASE N1


(Homo sapiens)
PF00069
(Pkinase)
PF00433
(Pkinase_C)
9 LEU A 627
VAL A 635
ALA A 648
VAL A 685
MET A 701
TYR A 703
GLY A 707
LEU A 753
ASP A 764
None
0.95A 4mxyB-4otdA:
23.1
4mxyB-4otdA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otd SERINE/THREONINE-PRO
TEIN KINASE N1


(Homo sapiens)
PF00069
(Pkinase)
PF00433
(Pkinase_C)
9 VAL A 635
ALA A 648
VAL A 685
MET A 701
TYR A 703
GLY A 707
LEU A 753
ALA A 763
ASP A 764
None
0.99A 4mxyB-4otdA:
23.1
4mxyB-4otdA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9z HUMAN PROTEIN KINASE
C THETA


(Homo sapiens)
PF00069
(Pkinase)
PF00433
(Pkinase_C)
8 LEU A 386
VAL A 394
ALA A 407
MET A 458
TYR A 460
LEU A 511
ALA A 521
ASP A 522
PZW  A 801 (-3.9A)
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
PZW  A 801 (-4.4A)
None
PZW  A 801 (-4.8A)
PZW  A 801 ( 4.6A)
PZW  A 801 (-3.2A)
0.70A 4mxyB-4q9zA:
18.4
4mxyB-4q9zA:
25.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 LEU A 616
VAL A 624
ALA A 642
LYS A 644
TYR A 693
GLY A 697
LEU A 818
P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-4.1A)
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
0.58A 4mxyB-4rt7A:
25.3
4mxyB-4rt7A:
31.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL


(synthetic
construct)
PF07714
(Pkinase_Tyr)
10 LEU A  14
VAL A  22
ALA A  35
GLU A  52
VAL A  65
TYR A  83
GLY A  87
LEU A 136
ALA A 146
ASP A 147
ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 ( 4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
None
0.67A 4mxyB-4ueuA:
36.8
4mxyB-4ueuA:
61.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL


(synthetic
construct)
PF07714
(Pkinase_Tyr)
9 LEU A  14
VAL A  22
ALA A  35
LYS A  37
TYR A  83
GLY A  87
LEU A 136
ALA A 146
ASP A 147
ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
ACP  A1264 ( 4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
None
0.59A 4mxyB-4ueuA:
36.8
4mxyB-4ueuA:
61.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE


(Homo sapiens)
PF00069
(Pkinase)
7 LEU A  40
VAL A  48
ALA A  61
VAL A  92
GLY A 114
LEU A 162
ALA A 172
6UI  A 700 ( 4.9A)
None
6UI  A 700 (-3.3A)
None
6UI  A 700 ( 4.2A)
6UI  A 700 (-4.2A)
6UI  A 700 ( 4.1A)
0.56A 4mxyB-4usfA:
17.7
4mxyB-4usfA:
26.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA


(Homo sapiens)
PF00069
(Pkinase)
PF00226
(DnaJ)
8 LEU A 104
VAL A 112
ALA A 125
LYS A 127
TYR A 177
GLY A 181
LEU A 228
ASP A 239
ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
None
None
ATP  A 501 (-4.5A)
ZN  A 503 (-1.9A)
0.95A 4mxyB-4wb7A:
22.9
4mxyB-4wb7A:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA


(Homo sapiens)
PF00069
(Pkinase)
PF00226
(DnaJ)
8 LEU A 104
VAL A 112
ALA A 125
LYS A 127
VAL A 159
TYR A 177
LEU A 228
ASP A 239
ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
None
None
ATP  A 501 (-4.5A)
ZN  A 503 (-1.9A)
0.97A 4mxyB-4wb7A:
22.9
4mxyB-4wb7A:
24.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1


(Homo sapiens)
no annotation 7 LEU B 267
VAL B 275
ALA B 288
VAL B 318
GLY B 340
LEU B 389
ALA B 399
1N1  B 601 (-3.7A)
1N1  B 601 ( 4.9A)
1N1  B 601 (-3.5A)
1N1  B 601 ( 4.3A)
1N1  B 601 (-3.5A)
1N1  B 601 (-4.3A)
1N1  B 601 (-3.5A)
0.51A 4mxyB-4xeyB:
26.8
4mxyB-4xeyB:
35.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xi2 TYROSINE-PROTEIN
KINASE BTK


(Mus musculus)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
7 LEU A 408
VAL A 416
ALA A 428
VAL A 458
TYR A 476
GLY A 480
LEU A 528
None
0.54A 4mxyB-4xi2A:
30.1
4mxyB-4xi2A:
27.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 LEU A 616
VAL A 624
ALA A 642
LYS A 644
TYR A 693
GLY A 697
LEU A 818
P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 ( 4.4A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
0.47A 4mxyB-4xufA:
30.0
4mxyB-4xufA:
37.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE


(Bos taurus)
PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr)
7 LEU A 408
VAL A 416
ALA A 428
VAL A 458
TYR A 476
GLY A 480
LEU A 528
746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
None
746  A 702 (-4.4A)
746  A 702 (-3.6A)
746  A 702 (-4.4A)
0.41A 4mxyB-4y93A:
31.3
4mxyB-4y93A:
26.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 LEU A 484
VAL A 492
ALA A 512
TYR A 563
GLY A 567
LEU A 630
ALA A 640
ASP A 641
38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 (-4.2A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
38O  A1769 (-4.0A)
0.80A 4mxyB-5a46A:
25.7
4mxyB-5a46A:
32.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1


(Homo sapiens)
PF00069
(Pkinase)
8 ALA A  44
GLU A  63
VAL A  76
MET A  92
TYR A  94
GLY A  98
LEU A 145
ALA A 164
51W  A 401 (-3.4A)
None
None
51W  A 401 (-3.9A)
51W  A 401 ( 3.4A)
51W  A 401 (-3.7A)
51W  A 401 (-4.5A)
None
0.87A 4mxyB-5ci7A:
25.6
4mxyB-5ci7A:
28.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1


(Homo sapiens)
PF00069
(Pkinase)
8 VAL A  30
ALA A  44
GLU A  63
VAL A  76
TYR A  94
GLY A  98
LEU A 145
ALA A 164
51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
None
None
51W  A 401 ( 3.4A)
51W  A 401 (-3.7A)
51W  A 401 (-4.5A)
None
0.89A 4mxyB-5ci7A:
25.6
4mxyB-5ci7A:
28.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4


(Homo sapiens)
PF00069
(Pkinase)
PF00627
(UBA)
8 ALA A  83
VAL A 116
MET A 132
TYR A 134
GLY A 138
LEU A 185
ALA A 195
ASP A 196
5RC  A4000 (-3.6A)
None
5RC  A4000 ( 4.0A)
5RC  A4000 (-4.5A)
5RC  A4000 (-3.3A)
None
5RC  A4000 ( 3.9A)
5RC  A4000 (-3.6A)
0.94A 4mxyB-5es1A:
21.2
4mxyB-5es1A:
28.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 LEU A 903
VAL A 911
ALA A 928
LYS A 930
TYR A 980
GLY A 984
LEU A1030
5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
5U3  A1200 (-4.5A)
5U3  A1200 (-3.2A)
5U3  A1200 (-4.4A)
0.60A 4mxyB-5f1zA:
29.1
4mxyB-5f1zA:
35.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 LEU A 730
VAL A 738
ALA A 756
GLU A 775
TYR A 806
GLY A 810
LEU A 881
PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-3.5A)
None
PTR  A 809 (-2.4A)
PP1  A2012 (-4.6A)
0.63A 4mxyB-5fm2A:
33.3
4mxyB-5fm2A:
31.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN


(Drosophila
melanogaster)
PF00069
(Pkinase)
8 LEU A  20
VAL A  28
ALA A  41
VAL A  74
GLY A  96
LEU A 143
ALA A 156
ASP A 157
ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
None
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
MG  A 302 ( 3.3A)
0.94A 4mxyB-5hu3A:
25.3
4mxyB-5hu3A:
26.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE


(Homo sapiens)
PF00069
(Pkinase)
8 LEU A  57
VAL A  65
ALA A  77
LYS A  79
VAL A 109
TYR A 132
GLY A 136
LEU A 187
IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
IDV  A 401 (-3.5A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
0.83A 4mxyB-5i3oA:
23.6
4mxyB-5i3oA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE


(Homo sapiens)
PF00069
(Pkinase)
8 LEU A  57
VAL A  65
ALA A  77
VAL A 109
TYR A 132
GLY A 136
LEU A 187
ASP A 198
IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
None
IDV  A 401 (-3.5A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
IDV  A 401 (-4.0A)
0.89A 4mxyB-5i3oA:
23.6
4mxyB-5i3oA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3


(Homo sapiens)
PF00069
(Pkinase)
8 VAL A  30
ALA A  43
LYS A  45
VAL A  74
GLY A  96
LEU A 143
ALA A 153
ASP A 154
6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
6G2  A 901 (-3.4A)
0.80A 4mxyB-5j5tA:
22.7
4mxyB-5j5tA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1


(Homo sapiens)
PF00069
(Pkinase)
8 VAL A 284
ALA A 297
LYS A 299
VAL A 328
MET A 344
TYR A 346
GLY A 350
LEU A 396
IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
None
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
IPW  A 601 ( 3.8A)
IPW  A 601 (-4.5A)
0.62A 4mxyB-5kbrA:
13.7
4mxyB-5kbrA:
27.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1


(Homo sapiens)
PF00069
(Pkinase)
8 VAL A 284
ALA A 297
LYS A 299
VAL A 328
MET A 344
TYR A 346
LEU A 396
ASP A 407
IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
None
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
IPW  A 601 (-4.5A)
None
0.67A 4mxyB-5kbrA:
13.7
4mxyB-5kbrA:
27.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u6b TYROSINE-PROTEIN
KINASE RECEPTOR UFO


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 LEU A 542
VAL A 550
ALA A 565
LYS A 567
GLY A 626
ALA A 689
ASP A 690
7YS  A9001 (-4.1A)
7YS  A9001 (-4.2A)
7YS  A9001 (-3.3A)
None
7YS  A9001 (-3.4A)
7YS  A9001 (-3.4A)
None
0.65A 4mxyB-5u6bA:
30.3
4mxyB-5u6bA:
37.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2


(Homo sapiens)
PF00069
(Pkinase)
8 ALA A 119
VAL A 153
MET A 169
TYR A 171
GLY A 175
LEU A 221
ALA A 231
ASP A 232
None
0.85A 4mxyB-5u7qA:
21.4
4mxyB-5u7qA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2


(Homo sapiens)
PF00069
(Pkinase)
8 VAL A 106
ALA A 119
VAL A 153
TYR A 171
GLY A 175
LEU A 221
ALA A 231
ASP A 232
None
0.76A 4mxyB-5u7qA:
21.4
4mxyB-5u7qA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23


(Caenorhabditis
elegans)
no annotation 7 LEU A 891
VAL A 899
ALA A 917
LYS A 919
TYR A 965
GLY A 969
LEU A1017
ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
ANP  A1201 (-4.4A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
0.66A 4mxyB-5wnoA:
28.0
4mxyB-5wnoA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3


(Homo sapiens)
no annotation 8 LEU A  33
VAL A  41
ALA A  54
VAL A  83
TYR A 101
GLY A 105
LEU A 153
ALA A 163
ANP  A 501 ( 3.8A)
ANP  A 501 (-4.4A)
ANP  A 501 ( 3.7A)
None
ANP  A 501 ( 4.2A)
ANP  A 501 ( 4.0A)
ANP  A 501 (-4.6A)
None
0.52A 4mxyB-6ao5A:
22.7
4mxyB-6ao5A:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bql CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2


(Homo sapiens)
no annotation 7 VAL A 179
ALA A 192
GLU A 236
VAL A 249
GLY A 273
LEU A 319
ALA A 329
BI9  A 501 ( 4.8A)
BI9  A 501 (-3.3A)
NH4  A 506 (-3.0A)
None
BI9  A 501 (-3.3A)
BI9  A 501 (-4.7A)
NH4  A 506 ( 3.7A)
0.64A 4mxyB-6bqlA:
24.5
4mxyB-6bqlA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1


(Homo sapiens)
no annotation 8 LEU A 881
VAL A 889
ALA A 906
LYS A 908
VAL A 938
GLY A 962
LEU A1010
ASP A1021
ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
MG  A1203 (-1.8A)
0.80A 4mxyB-6c7yA:
29.6
4mxyB-6c7yA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccf CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 1


(Homo sapiens)
no annotation 7 VAL A 142
ALA A 155
VAL A 212
GLY A 236
LEU A 282
ALA A 292
ASP A 293
H1N  A 501 (-4.4A)
H1N  A 501 (-3.4A)
H1N  A 501 (-4.9A)
H1N  A 501 (-3.6A)
H1N  A 501 (-4.8A)
H1N  A 501 ( 3.9A)
H1N  A 501 (-3.5A)
0.58A 4mxyB-6ccfA:
23.8
4mxyB-6ccfA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4


(Homo sapiens)
no annotation 9 VAL A 200
ALA A 211
LYS A 213
GLU A 233
VAL A 246
TYR A 264
GLY A 268
LEU A 318
ASP A 329
CJT  A 502 ( 4.8A)
CJT  A 502 (-3.4A)
CJT  A 502 (-3.0A)
CJT  A 502 (-3.9A)
None
CJT  A 502 (-4.5A)
CJT  A 502 ( 4.3A)
CJT  A 502 (-4.7A)
CJT  A 502 ( 4.0A)
0.79A 4mxyB-6f3dA:
25.6
4mxyB-6f3dA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdy -

(-)
no annotation 10 LEU U  20
VAL U  28
ALA U  42
LYS U  44
VAL U  75
MET U  91
GLY U  97
LEU U 144
ALA U 156
ASP U 157
DB8  U 301 (-3.7A)
DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.0A)
DB8  U 301 (-4.8A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.2A)
DB8  U 301 (-3.6A)
0.71A 4mxyB-6fdyU:
23.7
4mxyB-6fdyU:
undetectable