SIMILAR PATTERNS OF AMINO ACIDS FOR 4MXY_B_DB8B601
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k9a | CARBOXYL-TERMINALSRC KINASE (Rattusnorvegicus) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 7 | VAL A 209ALA A 220VAL A 249TYR A 268GLY A 272LEU A 321ASP A 332 | None | 0.59A | 4mxyB-1k9aA:32.9 | 4mxyB-1k9aA:29.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1luf | MUSCLE-SPECIFICTYROSINE KINASERECEPTOR MUSK (Rattusnorvegicus) |
PF07714(Pkinase_Tyr) | 9 | VAL A 588ALA A 606LYS A 608VAL A 638TYR A 656GLY A 660LEU A 731ALA A 741ASP A 742 | None | 0.86A | 4mxyB-1lufA:25.7 | 4mxyB-1lufA:33.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1opk | PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1 (Mus musculus) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 8 | LEU A 267VAL A 275ALA A 288LYS A 290VAL A 318GLY A 340LEU A 389ALA A 399 | P16 A 2 ( 4.2A)P16 A 2 (-4.5A)P16 A 2 (-3.4A)P16 A 2 (-4.5A)P16 A 2 ( 4.7A)P16 A 2 (-3.4A)P16 A 2 (-4.4A)P16 A 2 (-3.5A) | 0.96A | 4mxyB-1opkA:32.1 | 4mxyB-1opkA:29.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zlt | SERINE/THREONINE-PROTEIN KINASE CHK1 (Homo sapiens) |
PF00069(Pkinase) | 8 | LEU A 15VAL A 23ALA A 36LYS A 38TYR A 86GLY A 90LEU A 137ASP A 148 | HYM A 400 (-4.2A)HYM A 400 (-4.3A)HYM A 400 (-3.5A)HYM A 400 (-3.2A)HYM A 400 (-4.7A)NoneHYM A 400 (-4.5A)HYM A 400 (-3.9A) | 0.96A | 4mxyB-1zltA:22.8 | 4mxyB-1zltA:26.95 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2dq7 | PROTO-ONCOGENETYROSINE-PROTEINKINASE FYN (Homo sapiens) |
PF07714(Pkinase_Tyr) | 8 | LEU X 17VAL X 25ALA X 37GLU X 54VAL X 67TYR X 84ALA X 147ASP X 148 | STU X 902 (-3.8A)STU X 902 ( 4.8A)STU X 902 (-3.1A)STU X 902 ( 4.4A)NoneSTU X 902 (-4.6A)STU X 902 ( 4.1A)STU X 902 (-3.6A) | 0.90A | 4mxyB-2dq7X:37.5 | 4mxyB-2dq7X:83.39 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2dq7 | PROTO-ONCOGENETYROSINE-PROTEINKINASE FYN (Homo sapiens) |
PF07714(Pkinase_Tyr) | 10 | LEU X 17VAL X 25ALA X 37LYS X 39VAL X 67TYR X 84GLY X 88LEU X 137ALA X 147ASP X 148 | STU X 902 (-3.8A)STU X 902 ( 4.8A)STU X 902 (-3.1A)STU X 902 (-3.1A)NoneSTU X 902 (-4.6A)STU X 902 (-3.5A)STU X 902 (-4.4A)STU X 902 ( 4.1A)STU X 902 (-3.6A) | 0.84A | 4mxyB-2dq7X:37.5 | 4mxyB-2dq7X:83.39 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2h8h | PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC (Homo sapiens) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 9 | LEU A 273VAL A 281ALA A 293LYS A 295VAL A 323TYR A 340GLY A 344LEU A 393ASP A 404 | H8H A 534 (-3.8A)H8H A 534 (-4.4A)H8H A 534 (-3.2A)H8H A 534 (-3.7A)NoneH8H A 534 (-4.3A)H8H A 534 (-3.3A)H8H A 534 (-4.5A)H8H A 534 (-4.2A) | 0.74A | 4mxyB-2h8hA:34.1 | 4mxyB-2h8hA:52.90 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2h8h | PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC (Homo sapiens) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 9 | LEU A 273VAL A 281ALA A 293VAL A 323TYR A 340GLY A 344LEU A 393ALA A 403ASP A 404 | H8H A 534 (-3.8A)H8H A 534 (-4.4A)H8H A 534 (-3.2A)NoneH8H A 534 (-4.3A)H8H A 534 (-3.3A)H8H A 534 (-4.5A)H8H A 534 ( 4.0A)H8H A 534 (-4.2A) | 0.57A | 4mxyB-2h8hA:34.1 | 4mxyB-2h8hA:52.90 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2hck | HEMATOPOETIC CELLKINASE HCK (Homo sapiens) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 8 | LEU A 273VAL A 281ALA A 293LYS A 295VAL A 323GLY A 344LEU A 393ALA A 403 | QUE A 1 (-3.9A)QUE A 1 ( 4.8A)QUE A 1 (-3.5A)NoneNoneQUE A 1 (-3.0A)QUE A 1 (-4.4A)QUE A 1 ( 4.5A) | 0.76A | 4mxyB-2hckA:32.8 | 4mxyB-2hckA:50.68 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2hk5 | TYROSINE-PROTEINKINASE HCK (Homo sapiens) |
PF07714(Pkinase_Tyr) | 9 | LEU A 251VAL A 259ALA A 271GLU A 288VAL A 301GLY A 322LEU A 371ALA A 381ASP A 382 | 1BM A 499 ( 3.7A)1BM A 499 ( 4.8A)1BM A 499 (-3.6A)1BM A 499 (-3.2A)None1BM A 499 (-3.5A)1BM A 499 (-4.4A)1BM A 499 ( 3.7A)1BM A 499 (-4.4A) | 0.62A | 4mxyB-2hk5A:28.6 | 4mxyB-2hk5A:66.43 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2og8 | PROTO-ONCOGENETYROSINE-PROTEINKINASE LCK (Homo sapiens) |
PF07714(Pkinase_Tyr) | 8 | LEU A 251VAL A 259ALA A 271LYS A 273TYR A 318GLY A 322LEU A 371ALA A 381 | NoneNone1N8 A 501 ( 3.4A)1N8 A 501 ( 3.4A)1N8 A 501 ( 3.7A)1N8 A 501 ( 3.5A)1N8 A 501 ( 4.3A)1N8 A 501 ( 3.3A) | 0.94A | 4mxyB-2og8A:27.6 | 4mxyB-2og8A:66.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2og8 | PROTO-ONCOGENETYROSINE-PROTEINKINASE LCK (Homo sapiens) |
PF07714(Pkinase_Tyr) | 8 | LEU A 251VAL A 259ALA A 271VAL A 301TYR A 318GLY A 322LEU A 371ALA A 381 | NoneNone1N8 A 501 ( 3.4A)None1N8 A 501 ( 3.7A)1N8 A 501 ( 3.5A)1N8 A 501 ( 4.3A)1N8 A 501 ( 3.3A) | 0.88A | 4mxyB-2og8A:27.6 | 4mxyB-2og8A:66.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ogv | MACROPHAGECOLONY-STIMULATINGFACTOR 1 RECEPTORPRECURSOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 8 | LEU A 588VAL A 596ALA A 614VAL A 647TYR A 665GLY A 669LEU A 785ASP A 796 | None | 0.88A | 4mxyB-2ogvA:21.4 | 4mxyB-2ogvA:34.36 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2psq | FIBROBLAST GROWTHFACTOR RECEPTOR 2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A 487VAL A 495ALA A 515TYR A 566GLY A 570LEU A 633ALA A 643 | None | 0.66A | 4mxyB-2psqA:27.6 | 4mxyB-2psqA:31.90 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2qkw | PROTEIN KINASE (Solanumpimpinellifolium) |
PF07714(Pkinase_Tyr) | 8 | VAL B 55ALA B 67GLU B 85VAL B 98TYR B 116GLY B 120LEU B 171ASP B 182 | None | 0.69A | 4mxyB-2qkwB:20.6 | 4mxyB-2qkwB:30.40 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2r2p | EPHRIN TYPE-ARECEPTOR 5 (Homo sapiens) |
PF07714(Pkinase_Tyr)PF14575(EphA2_TM) | 7 | VAL A 689ALA A 705GLU A 724TYR A 755GLY A 759LEU A 807ASP A 818 | None | 0.60A | 4mxyB-2r2pA:30.2 | 4mxyB-2r2pA:42.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vd5 | DMPK PROTEIN (Homo sapiens) |
PF00069(Pkinase) | 8 | VAL A 85ALA A 98LYS A 100MET A 148TYR A 150LEU A 202ALA A 212ASP A 213 | BI8 A1417 ( 4.7A)BI8 A1417 ( 3.8A)BI8 A1417 (-4.2A)BI8 A1417 (-4.1A)BI8 A1417 (-4.8A)BI8 A1417 (-4.8A)BI8 A1417 ( 4.1A)BI8 A1417 (-3.8A) | 0.77A | 4mxyB-2vd5A:22.0 | 4mxyB-2vd5A:26.43 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2xik | SERINE/THREONINEPROTEIN KINASE 25 (Homo sapiens) |
PF00069(Pkinase) | 8 | ALA A 47LYS A 49MET A 95TYR A 97GLY A 101LEU A 147ALA A 157ASP A 158 | J60 A1294 (-3.3A)NoneJ60 A1294 ( 3.8A)J60 A1294 (-4.5A)J60 A1294 ( 3.8A)J60 A1294 (-4.8A)J60 A1294 ( 4.2A)J60 A1294 ( 4.6A) | 0.64A | 4mxyB-2xikA:20.5 | 4mxyB-2xikA:30.09 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2xik | SERINE/THREONINEPROTEIN KINASE 25 (Homo sapiens) |
PF00069(Pkinase) | 8 | VAL A 34ALA A 47LYS A 49TYR A 97GLY A 101LEU A 147ALA A 157ASP A 158 | J60 A1294 ( 4.9A)J60 A1294 (-3.3A)NoneJ60 A1294 (-4.5A)J60 A1294 ( 3.8A)J60 A1294 (-4.8A)J60 A1294 ( 4.2A)J60 A1294 ( 4.6A) | 0.71A | 4mxyB-2xikA:20.5 | 4mxyB-2xikA:30.09 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2zv7 | TYROSINE-PROTEINKINASE LYN (Mus musculus) |
PF07714(Pkinase_Tyr) | 9 | LEU A 253VAL A 261ALA A 273GLU A 290VAL A 303GLY A 325LEU A 374ALA A 384ASP A 385 | None | 0.57A | 4mxyB-2zv7A:37.7 | 4mxyB-2zv7A:63.99 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3b2t | FIBROBLAST GROWTHFACTOR RECEPTOR 2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 8 | LEU A 487VAL A 495ALA A 515GLU A 534TYR A 566GLY A 570LEU A 633ALA A 643 | M33 A1996 (-4.0A)M33 A1996 ( 4.7A)M33 A1996 (-3.3A)NoneM33 A1996 ( 4.7A)M33 A1996 ( 4.8A)M33 A1996 (-4.5A)None | 0.72A | 4mxyB-3b2tA:28.4 | 4mxyB-3b2tA:36.51 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3b2t | FIBROBLAST GROWTHFACTOR RECEPTOR 2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 8 | VAL A 495ALA A 515LYS A 517GLU A 534TYR A 566GLY A 570LEU A 633ALA A 643 | M33 A1996 ( 4.7A)M33 A1996 (-3.3A)M33 A1996 ( 4.5A)NoneM33 A1996 ( 4.7A)M33 A1996 ( 4.8A)M33 A1996 (-4.5A)None | 0.78A | 4mxyB-3b2tA:28.4 | 4mxyB-3b2tA:36.51 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3c4f | BASIC FIBROBLASTGROWTH FACTORRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 9 | LEU A 484VAL A 492ALA A 512LYS A 514TYR A 563GLY A 567LEU A 630ALA A 640ASP A 641 | C4F A 1 ( 3.9A)NoneC4F A 1 (-3.3A)NoneNoneNoneC4F A 1 (-4.6A)C4F A 1 (-3.6A)C4F A 1 (-4.5A) | 0.92A | 4mxyB-3c4fA:29.8 | 4mxyB-3c4fA:36.22 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3d7u | TYROSINE-PROTEINKINASE CSK (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | VAL A 209ALA A 220VAL A 249TYR A 268GLY A 272LEU A 321ASP A 332 | None | 0.59A | 4mxyB-3d7uA:27.2 | 4mxyB-3d7uA:40.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g2f | BONE MORPHOGENETICPROTEIN RECEPTORTYPE-2 (Homo sapiens) |
PF00069(Pkinase) | 7 | VAL A 217ALA A 228GLU A 243TYR A 281GLY A 285LEU A 340ASP A 351 | ADP A 900 (-4.3A)ADP A 900 (-3.4A)ADP A 900 ( 4.7A)NoneADP A 900 ( 4.2A)ADP A 900 (-4.6A)ADP A 900 ( 2.7A) | 0.63A | 4mxyB-3g2fA:20.7 | 4mxyB-3g2fA:26.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iec | SERINE/THREONINE-PROTEIN KINASE MARK2 (Homo sapiens) |
PF00069(Pkinase)PF00627(UBA) | 9 | VAL A 67ALA A 80LYS A 82VAL A 113TYR A 131GLY A 135LEU A 182ALA A 192ASP A 193 | None | 0.91A | 4mxyB-3iecA:24.6 | 4mxyB-3iecA:27.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iec | SERINE/THREONINE-PROTEIN KINASE MARK2 (Homo sapiens) |
PF00069(Pkinase)PF00627(UBA) | 9 | VAL A 67ALA A 80VAL A 113MET A 129TYR A 131GLY A 135LEU A 182ALA A 192ASP A 193 | None | 0.89A | 4mxyB-3iecA:24.6 | 4mxyB-3iecA:27.06 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3kex | RECEPTORTYROSINE-PROTEINKINASE ERBB-3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A 696VAL A 704VAL A 753TYR A 770GLY A 774LEU A 822ALA A 832 | ANP A 1 (-4.4A)ANP A 1 (-3.9A)NoneANP A 1 (-4.3A)ANP A 1 ( 4.9A)ANP A 1 (-4.7A)None | 0.67A | 4mxyB-3kexA:26.5 | 4mxyB-3kexA:32.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3my0 | SERINE/THREONINE-PROTEIN KINASE RECEPTORR3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 8 | VAL A 216ALA A 227GLU A 242TYR A 279GLY A 283LEU A 337ALA A 347ASP A 348 | LDN A 600 (-4.5A)LDN A 600 (-3.2A)NoneLDN A 600 (-4.7A)LDN A 600 (-3.3A)LDN A 600 (-4.6A)LDN A 600 ( 3.8A)None | 0.77A | 4mxyB-3my0A:26.8 | 4mxyB-3my0A:27.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3my0 | SERINE/THREONINE-PROTEIN KINASE RECEPTORR3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 8 | VAL A 216ALA A 227LYS A 229GLU A 242TYR A 279GLY A 283LEU A 337ASP A 348 | LDN A 600 (-4.5A)LDN A 600 (-3.2A)LDN A 600 (-4.0A)NoneLDN A 600 (-4.7A)LDN A 600 (-3.3A)LDN A 600 (-4.6A)None | 0.87A | 4mxyB-3my0A:26.8 | 4mxyB-3my0A:27.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nuu | PKB-LIKE (Homo sapiens) |
PF00069(Pkinase) | 8 | LEU A 88VAL A 96ALA A 109LYS A 111TYR A 161GLY A 165LEU A 212ASP A 223 | JOZ A 361 (-4.1A)JOZ A 361 ( 4.7A)JOZ A 361 (-3.4A)SO4 A 5 (-2.8A)NoneNoneNoneSO4 A 5 ( 4.5A) | 0.96A | 4mxyB-3nuuA:25.2 | 4mxyB-3nuuA:25.90 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ppz | SERINE/THREONINE-PROTEIN KINASE CTR1 (Arabidopsisthaliana) |
PF07714(Pkinase_Tyr) | 8 | VAL A 565ALA A 576LYS A 578VAL A 609TYR A 627GLY A 631LEU A 683ASP A 694 | STU A 1 (-4.9A)STU A 1 (-3.3A)STU A 1 (-3.5A)NoneSTU A 1 (-4.4A)STU A 1 (-3.2A)STU A 1 (-4.3A)STU A 1 (-3.5A) | 0.66A | 4mxyB-3ppzA:31.1 | 4mxyB-3ppzA:32.49 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3v5q | NT-3 GROWTH FACTORRECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 8 | LEU A 544VAL A 552ALA A 570LYS A 572VAL A 601TYR A 619GLY A 623LEU A 686 | 0F4 A 902 ( 4.2A)None0F4 A 902 (-3.2A)0F4 A 902 (-4.0A)None0F4 A 902 (-4.2A)0F4 A 902 (-3.4A)0F4 A 902 (-4.5A) | 0.74A | 4mxyB-3v5qA:24.9 | 4mxyB-3v5qA:35.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w18 | AURORA KINASE A (Homo sapiens) |
PF00069(Pkinase) | 8 | LEU A 139VAL A 147ALA A 160LYS A 162TYR A 212GLY A 216LEU A 263ALA A 273 | N13 A 501 (-3.7A)N13 A 501 ( 4.7A)N13 A 501 ( 4.1A)N13 A 501 (-2.9A)N13 A 501 (-4.4A)N13 A 501 (-3.5A)N13 A 501 (-4.5A)N13 A 501 ( 3.8A) | 0.91A | 4mxyB-3w18A:22.5 | 4mxyB-3w18A:24.08 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3wzd | VASCULAR ENDOTHELIALGROWTH FACTORRECEPTOR 2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 8 | LEU A 840VAL A 848ALA A 866LYS A 868VAL A 899GLY A 922LEU A1035ASP A1046 | LEV A1201 ( 3.8A)LEV A1201 ( 4.9A)LEV A1201 (-3.5A)NoneNoneLEV A1201 (-3.6A)LEV A1201 (-4.8A)GOL A1210 ( 3.4A) | 0.75A | 4mxyB-3wzdA:30.4 | 4mxyB-3wzdA:35.58 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A1951VAL A1959ALA A1978LYS A1980GLY A2032LEU A2086ASP A2102 | VGH A3000 ( 4.4A)NoneVGH A3000 (-3.4A)VGH A3000 ( 4.7A)VGH A3000 (-3.5A)VGH A3000 (-4.3A)None | 0.52A | 4mxyB-3zbfA:28.2 | 4mxyB-3zbfA:40.06 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4at3 | BDNF/NT-3 GROWTHFACTORS RECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 8 | LEU A 560VAL A 568ALA A 586LYS A 588VAL A 617TYR A 635GLY A 639LEU A 699 | LTI A1839 ( 4.2A)NoneLTI A1839 (-3.3A)NoneNoneLTI A1839 (-4.7A)LTI A1839 (-3.4A)LTI A1839 (-4.2A) | 0.68A | 4mxyB-4at3A:29.5 | 4mxyB-4at3A:34.53 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4at3 | BDNF/NT-3 GROWTHFACTORS RECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 8 | LEU A 560VAL A 568ALA A 586VAL A 617TYR A 635GLY A 639LEU A 699ASP A 710 | LTI A1839 ( 4.2A)NoneLTI A1839 (-3.3A)NoneLTI A1839 (-4.7A)LTI A1839 (-3.4A)LTI A1839 (-4.2A)None | 0.68A | 4mxyB-4at3A:29.5 | 4mxyB-4at3A:34.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aw2 | SERINE/THREONINE-PROTEIN KINASE MRCKALPHA (Rattusnorvegicus) |
PF00069(Pkinase)PF00433(Pkinase_C) | 8 | VAL A 91ALA A 104LYS A 106TYR A 156GLY A 160LEU A 208ALA A 218ASP A 219 | NoneEDO A1420 (-3.4A)EDO A1419 (-3.3A)EDO A1420 (-4.9A)NoneEDO A1420 ( 4.8A)NoneNone | 1.06A | 4mxyB-4aw2A:16.5 | 4mxyB-4aw2A:25.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bc6 | SERINE/THREONINE-PROTEIN KINASE 10 (Homo sapiens) |
PF00069(Pkinase) | 8 | LEU A 42VAL A 50ALA A 63LYS A 65VAL A 94GLY A 116LEU A 164ALA A 174 | XZN A1317 (-3.6A)XZN A1317 ( 4.7A)XZN A1317 (-3.5A)XZN A1317 (-4.1A)XZN A1317 (-4.4A)XZN A1317 ( 3.7A)XZN A1317 (-4.7A)XZN A1317 ( 4.3A) | 0.80A | 4mxyB-4bc6A:22.8 | 4mxyB-4bc6A:23.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c0t | LIKELY PROTEINKINASE (Candidaalbicans) |
PF00069(Pkinase) | 8 | LEU A 246VAL A 254ALA A 267LYS A 269TYR A 320GLY A 324LEU A 371ASP A 382 | None | 0.97A | 4mxyB-4c0tA:24.0 | 4mxyB-4c0tA:14.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cfh | 5'-AMP-ACTIVATEDPROTEIN KINASECATALYTIC SUBUNITALPHA-1 (Rattusnorvegicus) |
PF00069(Pkinase)PF16579(AdenylateSensor) | 8 | LEU A 22VAL A 30ALA A 43LYS A 45TYR A 95GLY A 99LEU A 146ASP A 157 | STU A1550 (-4.3A)NoneSTU A1550 (-3.1A)STU A1550 (-3.6A)STU A1550 (-4.5A)STU A1550 (-3.4A)STU A1550 (-4.3A)STU A1550 (-3.6A) | 0.99A | 4mxyB-4cfhA:24.6 | 4mxyB-4cfhA:22.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cfh | 5'-AMP-ACTIVATEDPROTEIN KINASECATALYTIC SUBUNITALPHA-1 (Rattusnorvegicus) |
PF00069(Pkinase)PF16579(AdenylateSensor) | 8 | VAL A 30ALA A 43LYS A 45TYR A 95GLY A 99LEU A 146ALA A 156ASP A 157 | NoneSTU A1550 (-3.1A)STU A1550 (-3.6A)STU A1550 (-4.5A)STU A1550 (-3.4A)STU A1550 (-4.3A)STU A1550 ( 3.8A)STU A1550 (-3.6A) | 0.96A | 4mxyB-4cfhA:24.6 | 4mxyB-4cfhA:22.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4crs | SERINE/THREONINE-PROTEIN KINASE N2 (Homo sapiens) |
PF00069(Pkinase)PF00433(Pkinase_C) | 8 | ALA A 684VAL A 721MET A 737TYR A 739GLY A 743LEU A 789ALA A 799ASP A 800 | AGS A1985 (-3.5A)NoneAGS A1985 (-4.2A)NoneNoneAGS A1985 (-4.8A)AGS A1985 ( 4.5A)AGS A1985 ( 3.3A) | 0.83A | 4mxyB-4crsA:22.6 | 4mxyB-4crsA:25.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4crs | SERINE/THREONINE-PROTEIN KINASE N2 (Homo sapiens) |
PF00069(Pkinase)PF00433(Pkinase_C) | 8 | LEU A 663VAL A 671ALA A 684LYS A 686TYR A 739GLY A 743LEU A 789ASP A 800 | AGS A1985 (-4.2A)AGS A1985 (-4.6A)AGS A1985 (-3.5A)AGS A1985 (-3.0A)NoneNoneAGS A1985 (-4.8A)AGS A1985 ( 3.3A) | 0.89A | 4mxyB-4crsA:22.6 | 4mxyB-4crsA:25.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4crs | SERINE/THREONINE-PROTEIN KINASE N2 (Homo sapiens) |
PF00069(Pkinase)PF00433(Pkinase_C) | 9 | LEU A 663VAL A 671ALA A 684VAL A 721TYR A 739GLY A 743LEU A 789ALA A 799ASP A 800 | AGS A1985 (-4.2A)AGS A1985 (-4.6A)AGS A1985 (-3.5A)NoneNoneNoneAGS A1985 (-4.8A)AGS A1985 ( 4.5A)AGS A1985 ( 3.3A) | 0.80A | 4mxyB-4crsA:22.6 | 4mxyB-4crsA:25.56 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4e93 | TYROSINE-PROTEINKINASE FES/FPS (Homo sapiens) |
PF00017(SH2)PF07714(Pkinase_Tyr) | 8 | VAL A 575ALA A 588GLU A 607VAL A 620MET A 636GLY A 642LEU A 690ASP A 701 | GUI A 901 (-4.5A)GUI A 901 (-3.4A)NoneNoneGUI A 901 ( 4.8A)GUI A 901 (-3.5A)GUI A 901 (-4.3A)GUI A 901 ( 4.1A) | 0.51A | 4mxyB-4e93A:28.5 | 4mxyB-4e93A:33.16 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4f0i | HIGH AFFINITY NERVEGROWTH FACTORRECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A 515VAL A 523ALA A 541LYS A 543VAL A 572GLY A 594LEU A 656 | None | 0.59A | 4mxyB-4f0iA:30.1 | 4mxyB-4f0iA:34.63 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4f0i | HIGH AFFINITY NERVEGROWTH FACTORRECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 8 | LEU A 515VAL A 523ALA A 541VAL A 572TYR A 590GLY A 594LEU A 656ASP A 667 | None | 0.72A | 4mxyB-4f0iA:30.1 | 4mxyB-4f0iA:34.63 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4f4p | TYROSINE-PROTEINKINASE SYK (Homo sapiens) |
PF07714(Pkinase_Tyr) | 9 | LEU A 377VAL A 385ALA A 400GLU A 420VAL A 433MET A 448GLY A 454LEU A 501ASP A 512 | 0SB A 701 ( 3.9A)0SB A 701 (-4.0A)0SB A 701 (-3.3A)NoneNone0SB A 701 (-3.6A)0SB A 701 (-3.5A)0SB A 701 (-4.4A)0SB A 701 (-3.9A) | 0.77A | 4mxyB-4f4pA:27.9 | 4mxyB-4f4pA:36.68 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4fod | ALK TYROSINE KINASERECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A1122VAL A1130ALA A1148VAL A1180GLY A1202LEU A1256ASP A1270 | 0UV A1501 (-3.8A)0UV A1501 (-4.5A)0UV A1501 (-3.4A)0UV A1501 ( 4.9A)0UV A1501 (-3.6A)0UV A1501 (-4.6A)0UV A1501 ( 4.2A) | 0.50A | 4mxyB-4fodA:24.6 | 4mxyB-4fodA:34.12 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4hvi | TYROSINE-PROTEINKINASE JAK3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 8 | ALA A 853VAL A 884MET A 902TYR A 904GLY A 908LEU A 956ALA A 966ASP A 967 | 19S A1201 (-3.3A)None19S A1201 (-3.6A)19S A1201 (-4.7A)19S A1201 ( 3.8A)19S A1201 (-4.5A)19S A1201 ( 4.1A)19S A1201 ( 4.1A) | 0.72A | 4mxyB-4hviA:24.9 | 4mxyB-4hviA:34.15 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4hvi | TYROSINE-PROTEINKINASE JAK3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 9 | LEU A 828ALA A 853LYS A 855VAL A 884TYR A 904GLY A 908LEU A 956ALA A 966ASP A 967 | 19S A1201 (-3.9A)19S A1201 (-3.3A)19S A1201 (-3.5A)None19S A1201 (-4.7A)19S A1201 ( 3.8A)19S A1201 (-4.5A)19S A1201 ( 4.1A)19S A1201 ( 4.1A) | 0.87A | 4mxyB-4hviA:24.9 | 4mxyB-4hviA:34.15 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4hvi | TYROSINE-PROTEINKINASE JAK3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 9 | LEU A 828VAL A 836ALA A 853LYS A 855TYR A 904GLY A 908LEU A 956ALA A 966ASP A 967 | 19S A1201 (-3.9A)19S A1201 (-4.4A)19S A1201 (-3.3A)19S A1201 (-3.5A)19S A1201 (-4.7A)19S A1201 ( 3.8A)19S A1201 (-4.5A)19S A1201 ( 4.1A)19S A1201 ( 4.1A) | 0.91A | 4mxyB-4hviA:24.9 | 4mxyB-4hviA:34.15 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4k11 | PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC (Homo sapiens) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 7 | LEU A 273ALA A 293TYR A 340GLY A 344LEU A 393ALA A 403ASP A 404 | 0J9 A 601 (-4.0A)0J9 A 601 (-3.3A)0J9 A 601 ( 4.7A)0J9 A 601 ( 4.1A)0J9 A 601 (-4.5A)0J9 A 601 (-3.5A)0J9 A 601 (-3.1A) | 0.66A | 4mxyB-4k11A:33.7 | 4mxyB-4k11A:94.93 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4k11 | PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC (Homo sapiens) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 8 | LEU A 273VAL A 281ALA A 293LYS A 295VAL A 323TYR A 340GLY A 344LEU A 393 | 0J9 A 601 (-4.0A)0J9 A 601 (-4.4A)0J9 A 601 (-3.3A)0J9 A 601 ( 4.7A)None0J9 A 601 ( 4.7A)0J9 A 601 ( 4.1A)0J9 A 601 (-4.5A) | 0.67A | 4mxyB-4k11A:33.7 | 4mxyB-4k11A:94.93 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4k11 | PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC (Homo sapiens) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 8 | LEU A 273VAL A 281ALA A 293VAL A 323TYR A 340GLY A 344LEU A 393ALA A 403 | 0J9 A 601 (-4.0A)0J9 A 601 (-4.4A)0J9 A 601 (-3.3A)None0J9 A 601 ( 4.7A)0J9 A 601 ( 4.1A)0J9 A 601 (-4.5A)0J9 A 601 (-3.5A) | 0.56A | 4mxyB-4k11A:33.7 | 4mxyB-4k11A:94.93 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4k33 | FIBROBLAST GROWTHFACTOR RECEPTOR 3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 8 | LEU A 478VAL A 486ALA A 506LYS A 508TYR A 557GLY A 561LEU A 624ASP A 635 | ACP A 801 (-3.8A)ACP A 801 (-4.2A)ACP A 801 (-3.3A)ACP A 801 (-2.7A)NoneACP A 801 ( 4.6A)ACP A 801 (-4.4A) MG A 802 ( 3.0A) | 0.79A | 4mxyB-4k33A:27.5 | 4mxyB-4k33A:35.95 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4k33 | FIBROBLAST GROWTHFACTOR RECEPTOR 3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 8 | LEU A 478VAL A 486ALA A 506TYR A 557GLY A 561LEU A 624ALA A 634ASP A 635 | ACP A 801 (-3.8A)ACP A 801 (-4.2A)ACP A 801 (-3.3A)NoneACP A 801 ( 4.6A)ACP A 801 (-4.4A)None MG A 802 ( 3.0A) | 0.73A | 4mxyB-4k33A:27.5 | 4mxyB-4k33A:35.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lg4 | SERINE/THREONINE-PROTEIN KINASE 3 (Homo sapiens) |
PF00069(Pkinase) | 8 | LEU A 33VAL A 41ALA A 54LYS A 56TYR A 101GLY A 105LEU A 153ALA A 163 | GOL A 404 ( 3.6A)GOL A 404 (-4.5A)GOL A 404 ( 3.1A)GOL A 403 ( 4.6A)GOL A 404 ( 4.9A)GOL A 404 (-3.6A)GOL A 403 ( 4.4A)GOL A 403 ( 3.0A) | 0.72A | 4mxyB-4lg4A:21.0 | 4mxyB-4lg4A:28.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lg4 | SERINE/THREONINE-PROTEIN KINASE 3 (Homo sapiens) |
PF00069(Pkinase) | 8 | LEU A 33VAL A 41ALA A 54VAL A 83TYR A 101GLY A 105LEU A 153ALA A 163 | GOL A 404 ( 3.6A)GOL A 404 (-4.5A)GOL A 404 ( 3.1A)GOL A 403 (-4.1A)GOL A 404 ( 4.9A)GOL A 404 (-3.6A)GOL A 403 ( 4.4A)GOL A 403 ( 3.0A) | 0.58A | 4mxyB-4lg4A:21.0 | 4mxyB-4lg4A:28.66 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4lgg | PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC (Gallus gallus) |
PF07714(Pkinase_Tyr) | 9 | LEU A 273VAL A 281ALA A 293GLU A 310VAL A 323TYR A 340GLY A 344ALA A 403ASP A 404 | VGG A 601 (-3.2A)VGG A 601 ( 3.5A)VGG A 601 (-3.5A)VGG A 601 ( 4.3A)VGG A 601 ( 4.8A)VGG A 601 ( 4.0A)VGG A 601 ( 3.2A)VGG A 601 ( 4.2A)VGG A 601 ( 4.7A) | 0.60A | 4mxyB-4lggA:38.1 | 4mxyB-4lggA:98.52 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4lgg | PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC (Gallus gallus) |
PF07714(Pkinase_Tyr) | 9 | LEU A 273VAL A 281ALA A 293GLU A 310VAL A 323TYR A 340GLY A 344LEU A 393ALA A 403 | VGG A 601 (-3.2A)VGG A 601 ( 3.5A)VGG A 601 (-3.5A)VGG A 601 ( 4.3A)VGG A 601 ( 4.8A)VGG A 601 ( 4.0A)VGG A 601 ( 3.2A)VGG A 601 (-4.5A)VGG A 601 ( 4.2A) | 0.32A | 4mxyB-4lggA:38.1 | 4mxyB-4lggA:98.52 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4o27 | SERINE/THREONINE-PROTEIN KINASE 24 (Homo sapiens) |
PF00069(Pkinase) | 8 | VAL B 38ALA B 51LYS B 53TYR B 101GLY B 105LEU B 151ALA B 161ASP B 162 | ADP B 500 (-4.5A)ADP B 500 (-3.3A)ADP B 500 (-3.1A)ADP B 500 ( 4.7A)NoneADP B 500 (-4.7A)NoneADP B 500 ( 3.4A) | 0.85A | 4mxyB-4o27B:23.1 | 4mxyB-4o27B:31.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4otd | SERINE/THREONINE-PROTEIN KINASE N1 (Homo sapiens) |
PF00069(Pkinase)PF00433(Pkinase_C) | 8 | LEU A 627VAL A 635ALA A 648LYS A 650VAL A 685TYR A 703GLY A 707LEU A 753 | None | 0.98A | 4mxyB-4otdA:23.1 | 4mxyB-4otdA:26.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4otd | SERINE/THREONINE-PROTEIN KINASE N1 (Homo sapiens) |
PF00069(Pkinase)PF00433(Pkinase_C) | 9 | LEU A 627VAL A 635ALA A 648VAL A 685MET A 701TYR A 703GLY A 707LEU A 753ASP A 764 | None | 0.95A | 4mxyB-4otdA:23.1 | 4mxyB-4otdA:26.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4otd | SERINE/THREONINE-PROTEIN KINASE N1 (Homo sapiens) |
PF00069(Pkinase)PF00433(Pkinase_C) | 9 | VAL A 635ALA A 648VAL A 685MET A 701TYR A 703GLY A 707LEU A 753ALA A 763ASP A 764 | None | 0.99A | 4mxyB-4otdA:23.1 | 4mxyB-4otdA:26.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q9z | HUMAN PROTEIN KINASEC THETA (Homo sapiens) |
PF00069(Pkinase)PF00433(Pkinase_C) | 8 | LEU A 386VAL A 394ALA A 407MET A 458TYR A 460LEU A 511ALA A 521ASP A 522 | PZW A 801 (-3.9A)PZW A 801 (-4.6A)PZW A 801 (-3.5A)PZW A 801 (-4.4A)NonePZW A 801 (-4.8A)PZW A 801 ( 4.6A)PZW A 801 (-3.2A) | 0.70A | 4mxyB-4q9zA:18.4 | 4mxyB-4q9zA:25.07 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4rt7 | RECEPTOR-TYPETYROSINE-PROTEINKINASE FLT3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A 616VAL A 624ALA A 642LYS A 644TYR A 693GLY A 697LEU A 818 | P30 A1001 (-3.8A)NoneP30 A1001 (-3.4A)P30 A1001 (-3.4A)P30 A1001 (-4.1A)P30 A1001 (-3.4A)P30 A1001 (-4.6A) | 0.58A | 4mxyB-4rt7A:25.3 | 4mxyB-4rt7A:31.92 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ueu | TYROSINE KINASE AS -A COMMON ANCESTOR OFSRC AND ABL (syntheticconstruct) |
PF07714(Pkinase_Tyr) | 10 | LEU A 14VAL A 22ALA A 35GLU A 52VAL A 65TYR A 83GLY A 87LEU A 136ALA A 146ASP A 147 | ACP A1264 ( 4.5A)ACP A1264 (-4.7A)ACP A1264 (-2.9A)NoneNoneACP A1264 ( 4.5A)ACP A1264 (-3.5A)ACP A1264 ( 4.8A)NoneNone | 0.67A | 4mxyB-4ueuA:36.8 | 4mxyB-4ueuA:61.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ueu | TYROSINE KINASE AS -A COMMON ANCESTOR OFSRC AND ABL (syntheticconstruct) |
PF07714(Pkinase_Tyr) | 9 | LEU A 14VAL A 22ALA A 35LYS A 37TYR A 83GLY A 87LEU A 136ALA A 146ASP A 147 | ACP A1264 ( 4.5A)ACP A1264 (-4.7A)ACP A1264 (-2.9A)NoneACP A1264 ( 4.5A)ACP A1264 (-3.5A)ACP A1264 ( 4.8A)NoneNone | 0.59A | 4mxyB-4ueuA:36.8 | 4mxyB-4ueuA:61.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4usf | STE20-LIKESERINE/THREONINE-PROTEIN KINASE (Homo sapiens) |
PF00069(Pkinase) | 7 | LEU A 40VAL A 48ALA A 61VAL A 92GLY A 114LEU A 162ALA A 172 | 6UI A 700 ( 4.9A)None6UI A 700 (-3.3A)None6UI A 700 ( 4.2A)6UI A 700 (-4.2A)6UI A 700 ( 4.1A) | 0.56A | 4mxyB-4usfA:17.7 | 4mxyB-4usfA:26.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wb7 | DNAJ HOMOLOGSUBFAMILY B MEMBER1,CAMP-DEPENDENTPROTEIN KINASECATALYTIC SUBUNITALPHA (Homo sapiens) |
PF00069(Pkinase)PF00226(DnaJ) | 8 | LEU A 104VAL A 112ALA A 125LYS A 127TYR A 177GLY A 181LEU A 228ASP A 239 | ATP A 501 ( 4.3A)ATP A 501 (-4.0A)ATP A 501 (-3.4A)ATP A 501 (-2.6A)NoneNoneATP A 501 (-4.5A) ZN A 503 (-1.9A) | 0.95A | 4mxyB-4wb7A:22.9 | 4mxyB-4wb7A:24.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wb7 | DNAJ HOMOLOGSUBFAMILY B MEMBER1,CAMP-DEPENDENTPROTEIN KINASECATALYTIC SUBUNITALPHA (Homo sapiens) |
PF00069(Pkinase)PF00226(DnaJ) | 8 | LEU A 104VAL A 112ALA A 125LYS A 127VAL A 159TYR A 177LEU A 228ASP A 239 | ATP A 501 ( 4.3A)ATP A 501 (-4.0A)ATP A 501 (-3.4A)ATP A 501 (-2.6A)NoneNoneATP A 501 (-4.5A) ZN A 503 (-1.9A) | 0.97A | 4mxyB-4wb7A:22.9 | 4mxyB-4wb7A:24.52 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4xey | TYROSINE-PROTEINKINASE ABL1 (Homo sapiens) |
no annotation | 7 | LEU B 267VAL B 275ALA B 288VAL B 318GLY B 340LEU B 389ALA B 399 | 1N1 B 601 (-3.7A)1N1 B 601 ( 4.9A)1N1 B 601 (-3.5A)1N1 B 601 ( 4.3A)1N1 B 601 (-3.5A)1N1 B 601 (-4.3A)1N1 B 601 (-3.5A) | 0.51A | 4mxyB-4xeyB:26.8 | 4mxyB-4xeyB:35.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xi2 | TYROSINE-PROTEINKINASE BTK (Mus musculus) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 7 | LEU A 408VAL A 416ALA A 428VAL A 458TYR A 476GLY A 480LEU A 528 | None | 0.54A | 4mxyB-4xi2A:30.1 | 4mxyB-4xi2A:27.31 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4xuf | RECEPTOR-TYPETYROSINE-PROTEINKINASE FLT3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A 616VAL A 624ALA A 642LYS A 644TYR A 693GLY A 697LEU A 818 | P30 A1001 (-4.0A)P30 A1001 ( 4.8A)P30 A1001 (-3.5A)P30 A1001 ( 4.0A)P30 A1001 ( 4.4A)P30 A1001 (-3.5A)P30 A1001 (-4.3A) | 0.47A | 4mxyB-4xufA:30.0 | 4mxyB-4xufA:37.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y93 | NON-SPECIFICPROTEIN-TYROSINEKINASE,NON-SPECIFICPROTEIN-TYROSINEKINASE (Bos taurus) |
PF00169(PH)PF00779(BTK)PF07714(Pkinase_Tyr) | 7 | LEU A 408VAL A 416ALA A 428VAL A 458TYR A 476GLY A 480LEU A 528 | 746 A 702 (-3.8A)746 A 702 ( 4.3A)746 A 702 (-2.4A)None746 A 702 (-4.4A)746 A 702 (-3.6A)746 A 702 (-4.4A) | 0.41A | 4mxyB-4y93A:31.3 | 4mxyB-4y93A:26.10 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5a46 | FIBROBLAST GROWTHFACTOR RECEPTOR 1(FMS-RELATEDTYROSINE KINASE 2,PFEIFFER SYNDROME),ISOFORM CRA_B (Homo sapiens) |
PF07714(Pkinase_Tyr) | 8 | LEU A 484VAL A 492ALA A 512TYR A 563GLY A 567LEU A 630ALA A 640ASP A 641 | 38O A1769 (-3.2A)38O A1769 (-4.5A)38O A1769 (-3.6A)38O A1769 (-4.2A)38O A1769 (-3.4A)38O A1769 (-4.6A)EDO A1766 ( 4.4A)38O A1769 (-4.0A) | 0.80A | 4mxyB-5a46A:25.7 | 4mxyB-5a46A:32.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ci7 | SERINE/THREONINE-PROTEIN KINASE ULK1 (Homo sapiens) |
PF00069(Pkinase) | 8 | ALA A 44GLU A 63VAL A 76MET A 92TYR A 94GLY A 98LEU A 145ALA A 164 | 51W A 401 (-3.4A)NoneNone51W A 401 (-3.9A)51W A 401 ( 3.4A)51W A 401 (-3.7A)51W A 401 (-4.5A)None | 0.87A | 4mxyB-5ci7A:25.6 | 4mxyB-5ci7A:28.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ci7 | SERINE/THREONINE-PROTEIN KINASE ULK1 (Homo sapiens) |
PF00069(Pkinase) | 8 | VAL A 30ALA A 44GLU A 63VAL A 76TYR A 94GLY A 98LEU A 145ALA A 164 | 51W A 401 ( 4.3A)51W A 401 (-3.4A)NoneNone51W A 401 ( 3.4A)51W A 401 (-3.7A)51W A 401 (-4.5A)None | 0.89A | 4mxyB-5ci7A:25.6 | 4mxyB-5ci7A:28.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5es1 | MAP/MICROTUBULEAFFINITY-REGULATINGKINASE 4 (Homo sapiens) |
PF00069(Pkinase)PF00627(UBA) | 8 | ALA A 83VAL A 116MET A 132TYR A 134GLY A 138LEU A 185ALA A 195ASP A 196 | 5RC A4000 (-3.6A)None5RC A4000 ( 4.0A)5RC A4000 (-4.5A)5RC A4000 (-3.3A)None5RC A4000 ( 3.9A)5RC A4000 (-3.6A) | 0.94A | 4mxyB-5es1A:21.2 | 4mxyB-5es1A:28.12 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5f1z | NON-RECEPTORTYROSINE-PROTEINKINASE TYK2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A 903VAL A 911ALA A 928LYS A 930TYR A 980GLY A 984LEU A1030 | 5U3 A1200 (-3.8A)5U3 A1200 ( 4.4A)5U3 A1200 (-3.5A)None5U3 A1200 (-4.5A)5U3 A1200 (-3.2A)5U3 A1200 (-4.4A) | 0.60A | 4mxyB-5f1zA:29.1 | 4mxyB-5f1zA:35.14 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5fm2 | PROTO-ONCOGENETYROSINE-PROTEINKINASE RECEPTOR RET (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A 730VAL A 738ALA A 756GLU A 775TYR A 806GLY A 810LEU A 881 | PP1 A2012 (-4.6A)PP1 A2012 (-4.4A)PP1 A2012 (-3.2A)PP1 A2012 (-3.5A)NonePTR A 809 (-2.4A)PP1 A2012 (-4.6A) | 0.63A | 4mxyB-5fm2A:33.3 | 4mxyB-5fm2A:31.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hu3 | CALCIUM/CALMODULIN-DEPENDENT PROTEINKINASE TYPE II ALPHACHAIN (Drosophilamelanogaster) |
PF00069(Pkinase) | 8 | LEU A 20VAL A 28ALA A 41VAL A 74GLY A 96LEU A 143ALA A 156ASP A 157 | ADP A 301 ( 4.0A)ADP A 301 (-3.7A)ADP A 301 (-3.5A)NoneNoneADP A 301 (-4.7A)ADP A 301 ( 4.8A) MG A 302 ( 3.3A) | 0.94A | 4mxyB-5hu3A:25.3 | 4mxyB-5hu3A:26.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i3o | BMP-2-INDUCIBLEPROTEIN KINASE (Homo sapiens) |
PF00069(Pkinase) | 8 | LEU A 57VAL A 65ALA A 77LYS A 79VAL A 109TYR A 132GLY A 136LEU A 187 | IDV A 401 (-3.8A)IDV A 401 (-4.6A)IDV A 401 (-3.6A)IDV A 401 ( 4.8A)NoneIDV A 401 (-3.5A)IDV A 401 (-3.4A)IDV A 401 (-4.4A) | 0.83A | 4mxyB-5i3oA:23.6 | 4mxyB-5i3oA:24.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i3o | BMP-2-INDUCIBLEPROTEIN KINASE (Homo sapiens) |
PF00069(Pkinase) | 8 | LEU A 57VAL A 65ALA A 77VAL A 109TYR A 132GLY A 136LEU A 187ASP A 198 | IDV A 401 (-3.8A)IDV A 401 (-4.6A)IDV A 401 (-3.6A)NoneIDV A 401 (-3.5A)IDV A 401 (-3.4A)IDV A 401 (-4.4A)IDV A 401 (-4.0A) | 0.89A | 4mxyB-5i3oA:23.6 | 4mxyB-5i3oA:24.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j5t | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE KINASE3 (Homo sapiens) |
PF00069(Pkinase) | 8 | VAL A 30ALA A 43LYS A 45VAL A 74GLY A 96LEU A 143ALA A 153ASP A 154 | 6G2 A 901 ( 4.9A)6G2 A 901 (-3.2A)6G2 A 901 ( 3.9A)None6G2 A 901 (-3.6A)6G2 A 901 (-4.7A)6G2 A 901 ( 4.2A)6G2 A 901 (-3.4A) | 0.80A | 4mxyB-5j5tA:22.7 | 4mxyB-5j5tA:24.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kbr | SERINE/THREONINE-PROTEIN KINASE PAK 1 (Homo sapiens) |
PF00069(Pkinase) | 8 | VAL A 284ALA A 297LYS A 299VAL A 328MET A 344TYR A 346GLY A 350LEU A 396 | IPW A 601 (-4.2A)IPW A 601 (-3.5A)IPW A 601 (-4.5A)NoneIPW A 601 (-3.5A)IPW A 601 (-4.5A)IPW A 601 ( 3.8A)IPW A 601 (-4.5A) | 0.62A | 4mxyB-5kbrA:13.7 | 4mxyB-5kbrA:27.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kbr | SERINE/THREONINE-PROTEIN KINASE PAK 1 (Homo sapiens) |
PF00069(Pkinase) | 8 | VAL A 284ALA A 297LYS A 299VAL A 328MET A 344TYR A 346LEU A 396ASP A 407 | IPW A 601 (-4.2A)IPW A 601 (-3.5A)IPW A 601 (-4.5A)NoneIPW A 601 (-3.5A)IPW A 601 (-4.5A)IPW A 601 (-4.5A)None | 0.67A | 4mxyB-5kbrA:13.7 | 4mxyB-5kbrA:27.53 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5u6b | TYROSINE-PROTEINKINASE RECEPTOR UFO (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A 542VAL A 550ALA A 565LYS A 567GLY A 626ALA A 689ASP A 690 | 7YS A9001 (-4.1A)7YS A9001 (-4.2A)7YS A9001 (-3.3A)None7YS A9001 (-3.4A)7YS A9001 (-3.4A)None | 0.65A | 4mxyB-5u6bA:30.3 | 4mxyB-5u6bA:37.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u7q | RHO-ASSOCIATEDPROTEIN KINASE 2 (Homo sapiens) |
PF00069(Pkinase) | 8 | ALA A 119VAL A 153MET A 169TYR A 171GLY A 175LEU A 221ALA A 231ASP A 232 | None | 0.85A | 4mxyB-5u7qA:21.4 | 4mxyB-5u7qA:24.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u7q | RHO-ASSOCIATEDPROTEIN KINASE 2 (Homo sapiens) |
PF00069(Pkinase) | 8 | VAL A 106ALA A 119VAL A 153TYR A 171GLY A 175LEU A 221ALA A 231ASP A 232 | None | 0.76A | 4mxyB-5u7qA:21.4 | 4mxyB-5u7qA:24.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wno | RECEPTORTYROSINE-PROTEINKINASE LET-23 (Caenorhabditiselegans) |
no annotation | 7 | LEU A 891VAL A 899ALA A 917LYS A 919TYR A 965GLY A 969LEU A1017 | ANP A1201 (-4.1A)ANP A1201 (-4.4A)ANP A1201 (-3.3A)ANP A1201 (-3.8A)ANP A1201 (-4.4A)ANP A1201 ( 4.6A)ANP A1201 (-4.7A) | 0.66A | 4mxyB-5wnoA:28.0 | 4mxyB-5wnoA:14.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ao5 | SERINE/THREONINE-PROTEIN KINASE 3 (Homo sapiens) |
no annotation | 8 | LEU A 33VAL A 41ALA A 54VAL A 83TYR A 101GLY A 105LEU A 153ALA A 163 | ANP A 501 ( 3.8A)ANP A 501 (-4.4A)ANP A 501 ( 3.7A)NoneANP A 501 ( 4.2A)ANP A 501 ( 4.0A)ANP A 501 (-4.6A)None | 0.52A | 4mxyB-6ao5A:22.7 | 4mxyB-6ao5A:25.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bql | CALCIUM/CALMODULIN-DEPENDENT PROTEINKINASE KINASE 2 (Homo sapiens) |
no annotation | 7 | VAL A 179ALA A 192GLU A 236VAL A 249GLY A 273LEU A 319ALA A 329 | BI9 A 501 ( 4.8A)BI9 A 501 (-3.3A)NH4 A 506 (-3.0A)NoneBI9 A 501 (-3.3A)BI9 A 501 (-4.7A)NH4 A 506 ( 3.7A) | 0.64A | 4mxyB-6bqlA:24.5 | 4mxyB-6bqlA:15.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c7y | TYROSINE-PROTEINKINASE JAK1 (Homo sapiens) |
no annotation | 8 | LEU A 881VAL A 889ALA A 906LYS A 908VAL A 938GLY A 962LEU A1010ASP A1021 | ADP A1201 ( 4.5A)ADP A1201 (-4.3A)ADP A1201 (-3.4A)ADP A1201 (-2.8A)NoneADP A1201 ( 4.1A)ADP A1201 (-4.5A) MG A1203 (-1.8A) | 0.80A | 4mxyB-6c7yA:29.6 | 4mxyB-6c7yA:16.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ccf | CALCIUM/CALMODULIN-DEPENDENT PROTEINKINASE KINASE 1 (Homo sapiens) |
no annotation | 7 | VAL A 142ALA A 155VAL A 212GLY A 236LEU A 282ALA A 292ASP A 293 | H1N A 501 (-4.4A)H1N A 501 (-3.4A)H1N A 501 (-4.9A)H1N A 501 (-3.6A)H1N A 501 (-4.8A)H1N A 501 ( 3.9A)H1N A 501 (-3.5A) | 0.58A | 4mxyB-6ccfA:23.8 | 4mxyB-6ccfA:14.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f3d | INTERLEUKIN-1RECEPTOR-ASSOCIATEDKINASE 4 (Homo sapiens) |
no annotation | 9 | VAL A 200ALA A 211LYS A 213GLU A 233VAL A 246TYR A 264GLY A 268LEU A 318ASP A 329 | CJT A 502 ( 4.8A)CJT A 502 (-3.4A)CJT A 502 (-3.0A)CJT A 502 (-3.9A)NoneCJT A 502 (-4.5A)CJT A 502 ( 4.3A)CJT A 502 (-4.7A)CJT A 502 ( 4.0A) | 0.79A | 4mxyB-6f3dA:25.6 | 4mxyB-6f3dA:13.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fdy | - (-) |
no annotation | 10 | LEU U 20VAL U 28ALA U 42LYS U 44VAL U 75MET U 91GLY U 97LEU U 144ALA U 156ASP U 157 | DB8 U 301 (-3.7A)DB8 U 301 ( 4.8A)DB8 U 301 (-3.6A)DB8 U 301 ( 4.0A)DB8 U 301 (-4.8A)DB8 U 301 (-4.8A)DB8 U 301 ( 4.1A)DB8 U 301 (-4.8A)DB8 U 301 ( 4.2A)DB8 U 301 (-3.6A) | 0.71A | 4mxyB-6fdyU:23.7 | 4mxyB-6fdyU:undetectable |