SIMILAR PATTERNS OF AMINO ACIDS FOR 4MXX_B_DB8B601

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k2p TYROSINE-PROTEIN
KINASE BTK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 ALA A 428
LYS A 430
VAL A 458
THR A 474
TYR A 476
MET A 477
GLY A 480
LEU A 528
None
0.65A 4mxxB-1k2pA:
24.9
4mxxB-1k2pA:
38.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k2p TYROSINE-PROTEIN
KINASE BTK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 VAL A 416
ALA A 428
LYS A 430
VAL A 458
TYR A 476
MET A 477
GLY A 480
LEU A 528
None
0.81A 4mxxB-1k2pA:
24.9
4mxxB-1k2pA:
38.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k9a CARBOXYL-TERMINAL
SRC KINASE


(Rattus
norvegicus)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
8 VAL A 209
ALA A 220
LYS A 222
VAL A 249
THR A 266
MET A 269
GLY A 272
LEU A 321
None
0.69A 4mxxB-1k9aA:
25.8
4mxxB-1k9aA:
30.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k9a CARBOXYL-TERMINAL
SRC KINASE


(Rattus
norvegicus)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
8 VAL A 209
ALA A 220
VAL A 249
THR A 266
TYR A 268
MET A 269
GLY A 272
LEU A 321
None
0.53A 4mxxB-1k9aA:
25.8
4mxxB-1k9aA:
30.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK


(Rattus
norvegicus)
PF07714
(Pkinase_Tyr)
7 VAL A 588
ALA A 606
VAL A 638
TYR A 656
MET A 657
GLY A 660
LEU A 731
None
0.53A 4mxxB-1lufA:
32.1
4mxxB-1lufA:
32.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1


(Mus musculus)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
9 LEU A 267
VAL A 275
ALA A 288
LYS A 290
VAL A 318
THR A 334
MET A 337
GLY A 340
LEU A 389
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 ( 4.7A)
P16  A   2 (-3.7A)
None
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
0.78A 4mxxB-1opkA:
31.6
4mxxB-1opkA:
30.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2


(Homo sapiens)
PF00069
(Pkinase)
8 LEU A  78
VAL A  86
ALA A  99
LYS A 101
VAL A 131
MET A 150
GLY A 153
LEU A 201
ATP  A 535 (-3.9A)
ATP  A 535 (-4.1A)
ATP  A 535 (-3.6A)
ATP  A 535 ( 2.5A)
5EA  A1001 (-4.5A)
None
ATP  A 535 ( 4.7A)
ATP  A 535 (-4.8A)
0.68A 4mxxB-1s9iA:
5.7
4mxxB-1s9iA:
26.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 VAL A 377
ALA A 389
LYS A 391
VAL A 419
MET A 438
GLY A 441
LEU A 489
None
0.48A 4mxxB-1snxA:
23.7
4mxxB-1snxA:
40.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 LEU A 595
VAL A 603
ALA A 621
LYS A 623
THR A 670
TYR A 672
GLY A 676
LEU A 799
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.2A)
STI  A   3 ( 4.0A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
0.73A 4mxxB-1t46A:
25.9
4mxxB-1t46A:
35.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1


(Homo sapiens)
PF00069
(Pkinase)
7 LEU A  15
VAL A  23
ALA A  36
LYS A  38
TYR A  86
GLY A  90
LEU A 137
HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
HYM  A 400 (-4.7A)
None
HYM  A 400 (-4.5A)
0.84A 4mxxB-1zltA:
14.9
4mxxB-1zltA:
26.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN


(Homo sapiens)
PF07714
(Pkinase_Tyr)
9 LEU X  17
VAL X  25
ALA X  37
LYS X  39
VAL X  67
THR X  82
MET X  85
GLY X  88
LEU X 137
STU  X 902 (-3.8A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
None
STU  X 902 (-4.1A)
None
STU  X 902 (-3.5A)
STU  X 902 (-4.4A)
0.80A 4mxxB-2dq7X:
35.0
4mxxB-2dq7X:
83.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN


(Homo sapiens)
PF07714
(Pkinase_Tyr)
9 LEU X  17
VAL X  25
ALA X  37
VAL X  67
THR X  82
TYR X  84
MET X  85
GLY X  88
LEU X 137
STU  X 902 (-3.8A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
None
STU  X 902 (-4.1A)
STU  X 902 (-4.6A)
None
STU  X 902 (-3.5A)
STU  X 902 (-4.4A)
0.68A 4mxxB-2dq7X:
35.0
4mxxB-2dq7X:
83.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC


(Homo sapiens)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
10 LEU A 273
VAL A 281
ALA A 293
LYS A 295
VAL A 323
THR A 338
TYR A 340
MET A 341
GLY A 344
LEU A 393
H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
None
H8H  A 534 (-3.1A)
H8H  A 534 (-4.3A)
None
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
0.46A 4mxxB-2h8hA:
33.6
4mxxB-2h8hA:
53.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hck HEMATOPOETIC CELL
KINASE HCK


(Homo sapiens)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
9 LEU A 273
VAL A 281
ALA A 293
LYS A 295
VAL A 323
THR A 338
MET A 341
GLY A 344
LEU A 393
QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.3A)
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
0.60A 4mxxB-2hckA:
32.5
4mxxB-2hckA:
50.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
9 LEU A 251
VAL A 259
ALA A 271
LYS A 273
VAL A 301
THR A 316
MET A 319
GLY A 322
LEU A 371
1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
None
1BM  A 499 (-3.2A)
None
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
0.61A 4mxxB-2hk5A:
27.1
4mxxB-2hk5A:
66.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 LEU A 248
VAL A 256
ALA A 269
LYS A 271
THR A 315
MET A 318
GLY A 321
LEU A 370
GIN  A 600 ( 4.6A)
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.4A)
None
None
GIN  A 600 (-4.7A)
0.66A 4mxxB-2hz0A:
30.7
4mxxB-2hz0A:
48.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 LEU A 248
VAL A 256
ALA A 269
VAL A 299
THR A 315
MET A 318
GLY A 321
LEU A 370
GIN  A 600 ( 4.6A)
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-4.6A)
GIN  A 600 (-3.4A)
None
None
GIN  A 600 (-4.7A)
0.74A 4mxxB-2hz0A:
30.7
4mxxB-2hz0A:
48.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 LEU A 251
ALA A 271
LYS A 273
THR A 316
TYR A 318
MET A 319
GLY A 322
LEU A 371
None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.7A)
1N8  A 501 ( 4.4A)
1N8  A 501 ( 3.5A)
1N8  A 501 ( 4.3A)
0.69A 4mxxB-2og8A:
27.8
4mxxB-2og8A:
67.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 LEU A 251
ALA A 271
VAL A 301
THR A 316
TYR A 318
MET A 319
GLY A 322
LEU A 371
None
1N8  A 501 ( 3.4A)
None
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.7A)
1N8  A 501 ( 4.4A)
1N8  A 501 ( 3.5A)
1N8  A 501 ( 4.3A)
0.77A 4mxxB-2og8A:
27.8
4mxxB-2og8A:
67.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 LEU A 251
VAL A 259
ALA A 271
LYS A 273
THR A 316
TYR A 318
MET A 319
LEU A 371
None
None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.7A)
1N8  A 501 ( 4.4A)
1N8  A 501 ( 4.3A)
0.68A 4mxxB-2og8A:
27.8
4mxxB-2og8A:
67.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 LEU A 251
VAL A 259
ALA A 271
VAL A 301
THR A 316
TYR A 318
MET A 319
LEU A 371
None
None
1N8  A 501 ( 3.4A)
None
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.7A)
1N8  A 501 ( 4.4A)
1N8  A 501 ( 4.3A)
0.74A 4mxxB-2og8A:
27.8
4mxxB-2og8A:
67.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 LEU A 588
VAL A 596
ALA A 614
LYS A 616
THR A 663
TYR A 665
GLY A 669
LEU A 785
None
0.84A 4mxxB-2ogvA:
21.0
4mxxB-2ogvA:
34.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 LEU A 588
VAL A 596
ALA A 614
VAL A 647
THR A 663
TYR A 665
GLY A 669
LEU A 785
None
0.75A 4mxxB-2ogvA:
21.0
4mxxB-2ogvA:
34.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus)
PF00069
(Pkinase)
7 LEU A  25
VAL A  33
ALA A  46
LYS A  48
MET A 106
GLY A 109
LEU A 156
ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
None
ATP  A 381 ( 4.8A)
0.83A 4mxxB-2phkA:
16.4
4mxxB-2phkA:
26.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qkw PROTEIN KINASE

(Solanum
pimpinellifolium)
PF07714
(Pkinase_Tyr)
8 VAL B  55
ALA B  67
VAL B  98
TYR B 116
MET B 117
GLY B 120
LEU B 171
THR B 181
None
0.75A 4mxxB-2qkwB:
23.5
4mxxB-2qkwB:
30.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qob EPHRIN RECEPTOR

(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 VAL A 635
ALA A 651
LYS A 653
THR A 699
MET A 702
GLY A 705
LEU A 753
BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
PTR  A 701 ( 3.5A)
None
None
0.61A 4mxxB-2qobA:
26.3
4mxxB-2qobA:
39.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5


(Homo sapiens)
PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM)
7 VAL A 689
ALA A 705
LYS A 707
TYR A 755
MET A 756
GLY A 759
LEU A 807
None
0.77A 4mxxB-2r2pA:
32.3
4mxxB-2r2pA:
43.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5


(Homo sapiens)
PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM)
7 VAL A 689
ALA A 705
THR A 753
TYR A 755
MET A 756
GLY A 759
LEU A 807
None
0.36A 4mxxB-2r2pA:
32.3
4mxxB-2r2pA:
43.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4


(Homo sapiens)
PF07714
(Pkinase_Tyr)
9 LEU A 724
VAL A 732
ALA A 749
LYS A 751
VAL A 781
THR A 796
MET A 799
GLY A 802
LEU A 850
GW7  A   1 ( 4.2A)
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 ( 4.7A)
GW7  A   1 (-4.0A)
None
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
0.77A 4mxxB-2r4bA:
26.5
4mxxB-2r4bA:
39.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xk9 CHECKPOINT KINASE 2

(Homo sapiens)
PF00069
(Pkinase)
7 LEU A 226
VAL A 234
ALA A 247
MET A 304
GLY A 307
LEU A 354
THR A 367
XK9  A1511 (-3.8A)
XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
None
XK9  A1511 ( 3.7A)
XK9  A1511 (-4.6A)
XK9  A1511 (-3.7A)
0.82A 4mxxB-2xk9A:
20.7
4mxxB-2xk9A:
28.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,


(Mus musculus)
PF07714
(Pkinase_Tyr)
7 VAL A 635
ALA A 651
LYS A 653
THR A 699
MET A 702
GLY A 705
LEU A 753
Q9G  A1898 ( 4.7A)
Q9G  A1898 (-3.2A)
Q9G  A1898 (-4.8A)
Q9G  A1898 (-3.5A)
None
Q9G  A1898 ( 3.8A)
Q9G  A1898 (-4.3A)
0.56A 4mxxB-2xyuA:
29.6
4mxxB-2xyuA:
43.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,


(Mus musculus)
PF07714
(Pkinase_Tyr)
7 VAL A 635
ALA A 651
THR A 699
TYR A 701
MET A 702
GLY A 705
LEU A 753
Q9G  A1898 ( 4.7A)
Q9G  A1898 (-3.2A)
Q9G  A1898 (-3.5A)
Q9G  A1898 (-4.8A)
None
Q9G  A1898 ( 3.8A)
Q9G  A1898 (-4.3A)
0.36A 4mxxB-2xyuA:
29.6
4mxxB-2xyuA:
43.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN


(Mus musculus)
PF07714
(Pkinase_Tyr)
9 LEU A 253
VAL A 261
ALA A 273
LYS A 275
VAL A 303
THR A 319
MET A 322
GLY A 325
LEU A 374
None
0.58A 4mxxB-2zv7A:
34.9
4mxxB-2zv7A:
64.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 LEU A 487
VAL A 495
ALA A 515
LYS A 517
TYR A 566
GLY A 570
LEU A 633
M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
M33  A1996 ( 4.7A)
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
0.68A 4mxxB-3b2tA:
26.2
4mxxB-3b2tA:
36.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 VAL A 209
ALA A 220
LYS A 222
VAL A 249
THR A 266
MET A 269
GLY A 272
LEU A 321
None
0.69A 4mxxB-3d7uA:
25.8
4mxxB-3d7uA:
41.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 VAL A 209
ALA A 220
VAL A 249
THR A 266
TYR A 268
MET A 269
GLY A 272
LEU A 321
None
0.53A 4mxxB-3d7uA:
25.8
4mxxB-3d7uA:
41.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7


(Homo sapiens)
PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM)
7 VAL A 647
ALA A 663
LYS A 665
VAL A 695
MET A 714
GLY A 717
LEU A 765
IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 ( 4.9A)
None
IHZ  A1001 ( 3.9A)
IHZ  A1001 (-4.6A)
0.56A 4mxxB-3dkoA:
32.0
4mxxB-3dkoA:
41.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 LEU A 833
VAL A 841
ALA A 859
LYS A 861
VAL A 892
TYR A 911
GLY A 915
LEU A1029
8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 ( 4.7A)
8ST  A2001 (-4.9A)
None
None
0.95A 4mxxB-3hngA:
29.3
4mxxB-3hngA:
31.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kex RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 LEU A 696
VAL A 704
LYS A 723
VAL A 753
THR A 768
TYR A 770
GLY A 774
LEU A 822
ANP  A   1 (-4.4A)
ANP  A   1 (-3.9A)
ANP  A   1 (-3.4A)
None
ANP  A   1 ( 4.8A)
ANP  A   1 (-4.3A)
ANP  A   1 ( 4.9A)
ANP  A   1 (-4.7A)
0.55A 4mxxB-3kexA:
27.7
4mxxB-3kexA:
32.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8


(Homo sapiens)
PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM)
7 VAL A 649
ALA A 665
THR A 713
TYR A 715
MET A 716
GLY A 719
LEU A 767
None
None
None
GOL  A 403 (-4.1A)
None
GOL  A 403 (-3.4A)
None
0.54A 4mxxB-3kulA:
33.3
4mxxB-3kulA:
38.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 LEU A1005
VAL A1013
ALA A1031
LYS A1033
VAL A1063
MET A1082
GLY A1085
None
None
None
CCX  A   1 ( 3.7A)
CCX  A   1 (-4.1A)
None
None
0.80A 4mxxB-3lw0A:
29.2
4mxxB-3lw0A:
36.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 VAL A 216
ALA A 227
LYS A 229
THR A 277
TYR A 279
GLY A 283
LEU A 337
LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
LDN  A 600 (-4.0A)
LDN  A 600 (-4.7A)
LDN  A 600 (-3.3A)
LDN  A 600 (-4.6A)
0.56A 4mxxB-3my0A:
25.0
4mxxB-3my0A:
27.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6


(Homo sapiens)
PF00069
(Pkinase)
PF00615
(RGS)
8 LEU A 192
VAL A 200
ALA A 213
LYS A 215
VAL A 247
MET A 266
GLY A 269
LEU A 318
AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
None
AMP  A 577 (-4.8A)
0.82A 4mxxB-3nyoA:
21.6
4mxxB-3nyoA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE


(Cryptosporidium
parvum)
PF00069
(Pkinase)
7 VAL A  25
ALA A  38
LYS A  40
VAL A  72
TYR A  92
MET A  93
LEU A 141
None
0.78A 4mxxB-3oz6A:
20.5
4mxxB-3oz6A:
23.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 LEU A 726
VAL A 734
ALA A 751
LYS A 753
MET A 801
GLY A 804
LEU A 852
03Q  A   1 (-3.8A)
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
None
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
0.68A 4mxxB-3pp0A:
29.4
4mxxB-3pp0A:
36.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 LEU A 726
VAL A 734
ALA A 751
THR A 798
MET A 801
GLY A 804
LEU A 852
03Q  A   1 (-3.8A)
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.1A)
None
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
0.61A 4mxxB-3pp0A:
29.4
4mxxB-3pp0A:
36.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1


(Arabidopsis
thaliana)
PF07714
(Pkinase_Tyr)
7 VAL A 565
ALA A 576
VAL A 609
THR A 625
TYR A 627
GLY A 631
LEU A 683
STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
None
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
0.40A 4mxxB-3ppzA:
29.2
4mxxB-3ppzA:
33.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX


(Homo sapiens)
PF07714
(Pkinase_Tyr)
9 LEU A 423
VAL A 431
ALA A 443
LYS A 445
VAL A 473
THR A 489
TYR A 491
GLY A 495
LEU A 543
PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
None
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
0.71A 4mxxB-3sxsA:
31.8
4mxxB-3sxsA:
43.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX


(Homo sapiens)
PF07714
(Pkinase_Tyr)
9 LEU A 423
VAL A 431
ALA A 443
VAL A 473
THR A 489
TYR A 491
GLY A 495
LEU A 543
PHE A 555
PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
None
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
PP2  A   1 ( 4.6A)
0.65A 4mxxB-3sxsA:
31.8
4mxxB-3sxsA:
43.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1


(Arabidopsis
thaliana)
PF00069
(Pkinase)
8 LEU A 295
VAL A 303
ALA A 315
LYS A 317
TYR A 365
MET A 366
GLY A 369
LEU A 423
None
0.83A 4mxxB-3ulzA:
21.9
4mxxB-3ulzA:
28.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v5q NT-3 GROWTH FACTOR
RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 LEU A 544
VAL A 552
ALA A 570
VAL A 601
TYR A 619
MET A 620
GLY A 623
LEU A 686
0F4  A 902 ( 4.2A)
None
0F4  A 902 (-3.2A)
None
0F4  A 902 (-4.2A)
None
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
0.70A 4mxxB-3v5qA:
24.9
4mxxB-3v5qA:
35.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1


(Homo sapiens)
PF00069
(Pkinase)
8 LEU A  75
VAL A  83
ALA A  96
LYS A  98
VAL A 128
MET A 147
GLY A 150
LEU A 198
ANP  A 401 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
ANP  A 401 (-2.7A)
CHU  A 403 (-4.2A)
None
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
0.70A 4mxxB-3wigA:
16.3
4mxxB-3wigA:
27.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 VAL A 633
ALA A 649
LYS A 651
THR A 697
MET A 700
GLY A 703
LEU A 751
None
0.62A 4mxxB-3zfxA:
33.0
4mxxB-3zfxA:
42.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af3 AURORA KINASE B

(Homo sapiens)
PF00069
(Pkinase)
7 LEU A  83
VAL A  91
ALA A 104
LYS A 106
TYR A 156
GLY A 160
LEU A 207
VX6  A 500 (-3.8A)
VX6  A 500 ( 4.8A)
VX6  A 500 (-3.4A)
VX6  A 500 (-3.3A)
VX6  A 500 (-4.2A)
VX6  A 500 (-3.3A)
VX6  A 500 (-4.6A)
0.68A 4mxxB-4af3A:
20.0
4mxxB-4af3A:
23.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 LEU A 560
VAL A 568
ALA A 586
VAL A 617
TYR A 635
MET A 636
GLY A 639
LEU A 699
LTI  A1839 ( 4.2A)
None
LTI  A1839 (-3.3A)
None
LTI  A1839 (-4.7A)
None
LTI  A1839 (-3.4A)
LTI  A1839 (-4.2A)
0.69A 4mxxB-4at3A:
23.8
4mxxB-4at3A:
34.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw5 EPHRIN TYPE-B
RECEPTOR 4


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 VAL A 105
ALA A 121
LYS A 123
THR A 169
MET A 172
GLY A 175
LEU A 223
30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
30K  A1365 (-3.8A)
None
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
0.35A 4mxxB-4aw5A:
29.8
4mxxB-4aw5A:
42.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1


(Homo sapiens)
PF00069
(Pkinase)
PF08515
(TGF_beta_GS)
7 VAL A 222
ALA A 233
LYS A 235
THR A 283
TYR A 285
GLY A 289
LEU A 343
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
TAK  A1507 (-3.6A)
TAK  A1507 ( 4.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
0.54A 4mxxB-4c02A:
24.7
4mxxB-4c02A:
27.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 LEU A 616
VAL A 624
ALA A 653
LYS A 655
THR A 701
TYR A 703
MET A 704
LEU A 773
None
DI1  A1000 (-4.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.9A)
DI1  A1000 (-3.6A)
DI1  A1000 (-4.0A)
None
DI1  A1000 (-4.5A)
0.81A 4mxxB-4ckrA:
29.6
4mxxB-4ckrA:
35.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2


(Homo sapiens)
PF00069
(Pkinase)
PF00433
(Pkinase_C)
7 LEU A 663
VAL A 671
ALA A 684
VAL A 721
TYR A 739
GLY A 743
LEU A 789
AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
0.81A 4mxxB-4crsA:
21.0
4mxxB-4crsA:
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 LEU A 515
VAL A 523
ALA A 541
VAL A 572
TYR A 590
MET A 591
GLY A 594
LEU A 656
None
0.51A 4mxxB-4f0iA:
23.7
4mxxB-4f0iA:
34.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f4p TYROSINE-PROTEIN
KINASE SYK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 LEU A 377
VAL A 385
ALA A 400
LYS A 402
VAL A 433
GLY A 454
LEU A 501
0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
0.58A 4mxxB-4f4pA:
25.9
4mxxB-4f4pA:
36.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK


(Homo sapiens)
PF00017
(SH2)
PF07714
(Pkinase_Tyr)
7 LEU A 377
VAL A 385
ALA A 400
LYS A 402
VAL A 433
GLY A 454
LEU A 501
ANP  A 701 ( 4.6A)
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 (-2.7A)
ANP  A 701 (-4.8A)
ANP  A 701 ( 4.2A)
ANP  A 701 (-4.5A)
0.77A 4mxxB-4fl3A:
28.7
4mxxB-4fl3A:
21.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fod ALK TYROSINE KINASE
RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 LEU A1122
VAL A1130
ALA A1148
VAL A1180
MET A1199
GLY A1202
LEU A1256
0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 ( 4.9A)
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
0.55A 4mxxB-4fodA:
30.0
4mxxB-4fodA:
34.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hzs ACTIVATED CDC42
KINASE 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
PF14604
(SH3_9)
7 LEU A 132
VAL A 140
ALA A 156
LYS A 158
THR A 205
GLY A 211
LEU A 259
None
0.57A 4mxxB-4hzsA:
20.9
4mxxB-4hzsA:
37.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4id7 ACTIVATED CDC42
KINASE 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 LEU A 132
VAL A 140
ALA A 156
LYS A 158
THR A 205
GLY A 211
LEU A 259
1G0  A 401 ( 4.5A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.5A)
1G0  A 401 (-4.6A)
0.73A 4mxxB-4id7A:
29.8
4mxxB-4id7A:
39.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC


(Homo sapiens)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
9 LEU A 273
VAL A 281
ALA A 293
LYS A 295
VAL A 323
TYR A 340
MET A 341
GLY A 344
LEU A 393
0J9  A 601 (-4.0A)
0J9  A 601 (-4.4A)
0J9  A 601 (-3.3A)
0J9  A 601 ( 4.7A)
None
0J9  A 601 ( 4.7A)
None
0J9  A 601 ( 4.1A)
0J9  A 601 (-4.5A)
0.64A 4mxxB-4k11A:
33.2
4mxxB-4k11A:
94.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3


(Homo sapiens)
PF00069
(Pkinase)
8 LEU A  33
VAL A  41
ALA A  54
LYS A  56
VAL A  83
TYR A 101
GLY A 105
LEU A 153
GOL  A 404 ( 3.6A)
GOL  A 404 (-4.5A)
GOL  A 404 ( 3.1A)
GOL  A 403 ( 4.6A)
GOL  A 403 (-4.1A)
GOL  A 404 ( 4.9A)
GOL  A 404 (-3.6A)
GOL  A 403 ( 4.4A)
0.71A 4mxxB-4lg4A:
19.8
4mxxB-4lg4A:
28.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC


(Gallus gallus)
PF07714
(Pkinase_Tyr)
9 LEU A 273
VAL A 281
ALA A 293
LYS A 295
VAL A 323
TYR A 340
MET A 341
GLY A 344
LEU A 393
VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 4.8A)
VGG  A 601 ( 4.0A)
None
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
0.61A 4mxxB-4lggA:
31.3
4mxxB-4lggA:
98.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3


(Mus musculus)
PF00069
(Pkinase)
7 VAL A  36
ALA A  49
LYS A  51
THR A  95
MET A  98
GLY A 101
LEU A 150
ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
ANP  A 401 (-3.8A)
None
None
ANP  A 401 (-4.8A)
0.75A 4mxxB-4m69A:
23.0
4mxxB-4m69A:
29.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE


(Homo sapiens)
PF00069
(Pkinase)
8 LEU A  46
VAL A  54
ALA A  67
LYS A  69
VAL A  99
THR A 123
GLY A 128
LEU A 180
SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
0.73A 4mxxB-4o38A:
20.1
4mxxB-4o38A:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 LEU A 595
VAL A 603
LYS A 642
THR A 687
TYR A 689
GLY A 693
LEU A 741
2TT  A1201 (-4.1A)
2TT  A1201 (-4.2A)
2TT  A1201 ( 4.6A)
None
2TT  A1201 (-4.0A)
2TT  A1201 (-3.5A)
2TT  A1201 (-4.1A)
0.52A 4mxxB-4oliA:
26.3
4mxxB-4oliA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otd SERINE/THREONINE-PRO
TEIN KINASE N1


(Homo sapiens)
PF00069
(Pkinase)
PF00433
(Pkinase_C)
7 LEU A 627
VAL A 635
ALA A 648
VAL A 685
TYR A 703
GLY A 707
LEU A 753
None
0.81A 4mxxB-4otdA:
21.6
4mxxB-4otdA:
26.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p2k EPHRIN TYPE-A
RECEPTOR 2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM)
7 VAL A 627
ALA A 644
THR A 692
TYR A 694
MET A 695
GLY A 698
LEU A 746
None
0.40A 4mxxB-4p2kA:
32.3
4mxxB-4p2kA:
44.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 LEU A 616
VAL A 624
ALA A 642
LYS A 644
TYR A 693
GLY A 697
LEU A 818
P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-4.1A)
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
0.68A 4mxxB-4rt7A:
25.6
4mxxB-4rt7A:
32.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 VAL A 624
ALA A 642
LYS A 644
VAL A 675
TYR A 693
GLY A 697
LEU A 818
None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
None
P30  A1001 (-4.1A)
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
0.82A 4mxxB-4rt7A:
25.6
4mxxB-4rt7A:
32.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL


(synthetic
construct)
PF07714
(Pkinase_Tyr)
10 LEU A  14
VAL A  22
ALA A  35
LYS A  37
VAL A  65
THR A  81
TYR A  83
MET A  84
GLY A  87
LEU A 136
ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
None
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
0.56A 4mxxB-4ueuA:
34.1
4mxxB-4ueuA:
62.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE


(Homo sapiens)
PF00069
(Pkinase)
7 LEU A  40
VAL A  48
ALA A  61
LYS A  63
VAL A  92
GLY A 114
LEU A 162
6UI  A 700 ( 4.9A)
None
6UI  A 700 (-3.3A)
6UI  A 700 (-4.5A)
None
6UI  A 700 ( 4.2A)
6UI  A 700 (-4.2A)
0.77A 4mxxB-4usfA:
17.8
4mxxB-4usfA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus)
PF00069
(Pkinase)
PF00615
(RGS)
8 LEU A 193
VAL A 201
ALA A 214
LYS A 216
VAL A 248
MET A 267
GLY A 270
LEU A 321
ANW  A 601 ( 4.0A)
None
ANW  A 601 (-3.4A)
None
None
None
ANW  A 601 ( 4.5A)
ANW  A 601 (-4.9A)
0.88A 4mxxB-4wboA:
22.8
4mxxB-4wboA:
20.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1


(Homo sapiens)
no annotation 10 LEU B 267
VAL B 275
ALA B 288
LYS B 290
VAL B 318
THR B 334
MET B 337
GLY B 340
LEU B 389
PHE B 401
1N1  B 601 (-3.7A)
1N1  B 601 ( 4.9A)
1N1  B 601 (-3.5A)
1N1  B 601 (-4.6A)
1N1  B 601 ( 4.3A)
1N1  B 601 (-3.3A)
None
1N1  B 601 (-3.5A)
1N1  B 601 (-4.3A)
None
0.57A 4mxxB-4xeyB:
32.5
4mxxB-4xeyB:
36.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xi2 TYROSINE-PROTEIN
KINASE BTK


(Mus musculus)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
9 LEU A 408
VAL A 416
ALA A 428
VAL A 458
THR A 474
TYR A 476
MET A 477
GLY A 480
LEU A 528
None
0.67A 4mxxB-4xi2A:
25.5
4mxxB-4xi2A:
27.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 LEU A 616
VAL A 624
ALA A 642
VAL A 675
TYR A 693
GLY A 697
LEU A 818
P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
None
P30  A1001 ( 4.4A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
0.74A 4mxxB-4xufA:
23.3
4mxxB-4xufA:
37.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE


(Bos taurus)
PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr)
10 LEU A 408
VAL A 416
ALA A 428
LYS A 430
VAL A 458
THR A 474
TYR A 476
MET A 477
GLY A 480
LEU A 528
746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
None
746  A 702 (-3.7A)
746  A 702 (-4.4A)
None
746  A 702 (-3.6A)
746  A 702 (-4.4A)
0.73A 4mxxB-4y93A:
31.0
4mxxB-4y93A:
26.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 LEU A 484
VAL A 492
ALA A 512
LYS A 514
TYR A 563
GLY A 567
LEU A 630
38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
38O  A1769 (-4.2A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
0.82A 4mxxB-5a46A:
30.6
4mxxB-5a46A:
32.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 LEU A 903
VAL A 911
ALA A 928
LYS A 930
TYR A 980
GLY A 984
LEU A1030
5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
5U3  A1200 (-4.5A)
5U3  A1200 (-3.2A)
5U3  A1200 (-4.4A)
0.68A 4mxxB-5f1zA:
22.3
4mxxB-5f1zA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 LEU A 730
VAL A 738
ALA A 756
LYS A 758
TYR A 806
GLY A 810
LEU A 881
PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
None
PTR  A 809 (-2.4A)
PP1  A2012 (-4.6A)
0.72A 4mxxB-5fm2A:
30.9
4mxxB-5fm2A:
31.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 LEU A 599
VAL A 607
ALA A 625
LYS A 627
THR A 674
TYR A 676
GLY A 680
LEU A 825
748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
0.74A 4mxxB-5grnA:
24.3
4mxxB-5grnA:
33.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz8 PROTEIN O-MANNOSE
KINASE


(Mus musculus)
PF07714
(Pkinase_Tyr)
7 VAL A  94
ALA A 105
VAL A 134
THR A 148
TYR A 150
GLY A 154
LEU A 215
None
0.71A 4mxxB-5gz8A:
19.0
4mxxB-5gz8A:
26.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gza PROTEIN O-MANNOSE
KINASE


(Danio rerio)
PF07714
(Pkinase_Tyr)
7 VAL A  93
ALA A 104
VAL A 133
THR A 147
TYR A 149
GLY A 153
LEU A 214
ADP  A 401 (-4.4A)
ADP  A 401 (-3.2A)
None
ADP  A 401 ( 4.8A)
ADP  A 401 ( 4.8A)
ADP  A 401 ( 4.1A)
ADP  A 401 (-4.4A)
0.63A 4mxxB-5gzaA:
12.7
4mxxB-5gzaA:
29.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE


(Homo sapiens)
PF00069
(Pkinase)
7 LEU A  57
VAL A  65
ALA A  77
VAL A 109
TYR A 132
GLY A 136
LEU A 187
IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
None
IDV  A 401 (-3.5A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
0.79A 4mxxB-5i3oA:
22.2
4mxxB-5i3oA:
24.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 LEU A 718
VAL A 726
ALA A 743
LYS A 745
MET A 793
GLY A 796
LEU A 844
THR A 854
6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
None
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
6HJ  A1101 (-3.9A)
0.66A 4mxxB-5j9zA:
31.2
4mxxB-5j9zA:
33.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1


(Homo sapiens)
PF00069
(Pkinase)
8 VAL A 284
ALA A 297
LYS A 299
VAL A 328
TYR A 346
GLY A 350
LEU A 396
THR A 406
IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
None
IPW  A 601 (-4.5A)
IPW  A 601 ( 3.8A)
IPW  A 601 (-4.5A)
IPW  A 601 (-3.7A)
0.80A 4mxxB-5kbrA:
22.6
4mxxB-5kbrA:
27.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0y SERINE/THREONINE-PRO
TEIN KINASE
TOUSLED-LIKE 2


(Homo sapiens)
no annotation 7 LEU A 468
VAL A 476
ALA A 489
LYS A 491
VAL A 527
TYR A 546
THR A 612
AGS  A 801 (-4.1A)
AGS  A 801 (-4.0A)
AGS  A 801 (-3.6A)
AGS  A 801 (-2.8A)
None
AGS  A 801 ( 4.8A)
None
0.77A 4mxxB-5o0yA:
14.4
4mxxB-5o0yA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2


(Homo sapiens)
PF00069
(Pkinase)
8 VAL A 106
ALA A 119
LYS A 121
VAL A 153
TYR A 171
MET A 172
GLY A 175
LEU A 221
None
0.85A 4mxxB-5u7qA:
19.6
4mxxB-5u7qA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2


(Homo sapiens)
no annotation 9 LEU A  24
VAL A  32
ALA A  45
LYS A  47
THR A  95
TYR A  97
MET A  98
GLY A 101
LEU A 153
9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.2A)
None
None
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
0.76A 4mxxB-5w5jA:
18.2
4mxxB-5w5jA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23


(Caenorhabditis
elegans)
no annotation 8 LEU A 891
VAL A 899
ALA A 917
LYS A 919
THR A 963
TYR A 965
GLY A 969
LEU A1017
ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
ANP  A1201 (-3.9A)
ANP  A1201 (-4.4A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
0.74A 4mxxB-5wnoA:
27.9
4mxxB-5wnoA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN


(Arabidopsis
thaliana)
no annotation 7 VAL A  83
ALA A  95
LYS A  97
VAL A 125
TYR A 143
GLY A 147
LEU A 206
ANP  A1000 (-4.1A)
ANP  A1000 (-3.2A)
ANP  A1000 (-2.8A)
None
ANP  A1000 (-4.3A)
None
ANP  A1000 (-4.5A)
0.68A 4mxxB-5xd6A:
22.4
4mxxB-5xd6A:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3


(Homo sapiens)
no annotation 8 LEU A  33
VAL A  41
ALA A  54
LYS A  56
VAL A  83
TYR A 101
GLY A 105
LEU A 153
ANP  A 501 ( 3.8A)
ANP  A 501 (-4.4A)
ANP  A 501 ( 3.7A)
ANP  A 501 (-2.4A)
None
ANP  A 501 ( 4.2A)
ANP  A 501 ( 4.0A)
ANP  A 501 (-4.6A)
0.62A 4mxxB-6ao5A:
22.5
4mxxB-6ao5A:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1


(Homo sapiens)
no annotation 7 LEU A 881
VAL A 889
ALA A 906
LYS A 908
VAL A 938
GLY A 962
LEU A1010
ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
0.85A 4mxxB-6c7yA:
27.6
4mxxB-6c7yA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6


(Homo sapiens)
no annotation 8 LEU A 197
VAL A 205
ALA A 217
LYS A 219
THR A 264
MET A 267
GLY A 270
LEU A 319
FKY  A9001 (-4.1A)
FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
None
FKY  A9001 (-3.0A)
None
FKY  A9001 (-3.3A)
FKY  A9001 ( 4.9A)
0.96A 4mxxB-6cz4A:
19.8
4mxxB-6cz4A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4


(Homo sapiens)
no annotation 7 VAL A 200
ALA A 211
VAL A 246
TYR A 264
MET A 265
GLY A 268
LEU A 318
CJT  A 502 ( 4.8A)
CJT  A 502 (-3.4A)
None
CJT  A 502 (-4.5A)
CJT  A 502 (-4.9A)
CJT  A 502 ( 4.3A)
CJT  A 502 (-4.7A)
0.50A 4mxxB-6f3dA:
23.6
4mxxB-6f3dA:
13.57