SIMILAR PATTERNS OF AMINO ACIDS FOR 4MXX_A_DB8A601_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k2p TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 428
LYS A 430
VAL A 458
ILE A 472
TYR A 476
GLY A 480
LEU A 528
 None
 0.62A 4mxxA-1k2pA:
26.7		 4mxxA-1k2pA:
38.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k2p TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 428
LYS A 430
VAL A 458
THR A 474
TYR A 476
GLY A 480
LEU A 528
 None
 0.59A 4mxxA-1k2pA:
26.7		 4mxxA-1k2pA:
38.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		9 ALA A 220
LYS A 222
GLU A 236
MET A 240
VAL A 249
THR A 266
TYR A 268
GLY A 272
LEU A 321
 None
 0.86A 4mxxA-1k9aA:
32.6		 4mxxA-1k9aA:
30.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		9 ALA A 220
LYS A 222
GLU A 236
VAL A 249
ILE A 264
THR A 266
TYR A 268
GLY A 272
LEU A 321
 None
 0.77A 4mxxA-1k9aA:
32.6		 4mxxA-1k9aA:
30.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 ALA A 288
LYS A 290
GLU A 305
MET A 309
VAL A 318
THR A 334
GLY A 340
LEU A 389
 P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 ( 4.7A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
 0.88A 4mxxA-1opkA:
32.1		 4mxxA-1opkA:
30.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 ALA A 288
LYS A 290
GLU A 305
VAL A 318
ILE A 332
THR A 334
GLY A 340
LEU A 389
 P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
 0.78A 4mxxA-1opkA:
32.1		 4mxxA-1opkA:
30.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 LEU A 267
ALA A 288
LYS A 290
GLU A 305
ILE A 332
THR A 334
GLY A 340
LEU A 389
 P16  A   2 ( 4.2A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
 0.93A 4mxxA-1opkA:
32.1		 4mxxA-1opkA:
30.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 LEU A 267
ALA A 288
LYS A 290
GLU A 305
MET A 309
THR A 334
GLY A 340
LEU A 389
 P16  A   2 ( 4.2A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
 1.04A 4mxxA-1opkA:
32.1		 4mxxA-1opkA:
30.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 621
GLU A 640
VAL A 654
THR A 670
TYR A 672
GLY A 676
LEU A 799
 STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-4.3A)
STI  A   3 (-3.2A)
STI  A   3 ( 4.0A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
 0.80A 4mxxA-1t46A:
24.7		 4mxxA-1t46A:
35.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 595
ALA A 621
LYS A 623
GLU A 640
THR A 670
TYR A 672
GLY A 676
LEU A 799
 STI  A   3 ( 3.8A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 ( 4.0A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
 0.94A 4mxxA-1t46A:
24.7		 4mxxA-1t46A:
35.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA X  37
LYS X  39
GLU X  54
MET X  58
VAL X  67
THR X  82
TYR X  84
GLY X  88
LEU X 137
 STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
None
STU  X 902 (-4.1A)
STU  X 902 (-4.6A)
STU  X 902 (-3.5A)
STU  X 902 (-4.4A)
 0.80A 4mxxA-2dq7X:
37.1		 4mxxA-2dq7X:
83.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA X  37
LYS X  39
GLU X  54
VAL X  67
ILE X  80
THR X  82
TYR X  84
GLY X  88
LEU X 137
 STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
None
STU  X 902 (-4.1A)
STU  X 902 (-4.6A)
STU  X 902 (-3.5A)
STU  X 902 (-4.4A)
 0.71A 4mxxA-2dq7X:
37.1		 4mxxA-2dq7X:
83.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU X  17
ALA X  37
LYS X  39
GLU X  54
ILE X  80
THR X  82
TYR X  84
GLY X  88
LEU X 137
 STU  X 902 (-3.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
STU  X 902 (-4.1A)
STU  X 902 (-4.6A)
STU  X 902 (-3.5A)
STU  X 902 (-4.4A)
 0.82A 4mxxA-2dq7X:
37.1		 4mxxA-2dq7X:
83.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU X  17
ALA X  37
LYS X  39
GLU X  54
MET X  58
THR X  82
TYR X  84
GLY X  88
LEU X 137
 STU  X 902 (-3.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
STU  X 902 (-4.1A)
STU  X 902 (-4.6A)
STU  X 902 (-3.5A)
STU  X 902 (-4.4A)
 0.92A 4mxxA-2dq7X:
37.1		 4mxxA-2dq7X:
83.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		9 LEU A 273
ALA A 293
LYS A 295
VAL A 323
ILE A 336
THR A 338
TYR A 340
GLY A 344
LEU A 393
 H8H  A 534 (-3.8A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
None
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
H8H  A 534 (-4.3A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
 0.55A 4mxxA-2h8hA:
33.8		 4mxxA-2h8hA:
53.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 LEU A 273
ALA A 293
LYS A 295
VAL A 323
ILE A 336
THR A 338
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
None
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.64A 4mxxA-2hckA:
32.5		 4mxxA-2hckA:
50.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 251
ALA A 271
LYS A 273
GLU A 288
MET A 292
VAL A 301
ILE A 314
THR A 316
GLY A 322
LEU A 371
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
 0.66A 4mxxA-2hk5A:
29.5		 4mxxA-2hk5A:
66.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 248
ALA A 269
GLU A 286
MET A 290
VAL A 299
THR A 315
GLY A 321
LEU A 370
 GIN  A 600 ( 4.6A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.2A)
GIN  A 600 (-4.6A)
GIN  A 600 (-3.4A)
None
GIN  A 600 (-4.7A)
 1.00A 4mxxA-2hz0A:
32.6		 4mxxA-2hz0A:
48.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 248
ALA A 269
GLU A 286
VAL A 299
ILE A 313
THR A 315
GLY A 321
LEU A 370
 GIN  A 600 ( 4.6A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-4.6A)
GIN  A 600 (-3.8A)
GIN  A 600 (-3.4A)
None
GIN  A 600 (-4.7A)
 0.93A 4mxxA-2hz0A:
32.6		 4mxxA-2hz0A:
48.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 248
ALA A 269
LYS A 271
GLU A 286
ILE A 313
THR A 315
GLY A 321
LEU A 370
 GIN  A 600 ( 4.6A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.8A)
GIN  A 600 (-3.4A)
None
GIN  A 600 (-4.7A)
 0.97A 4mxxA-2hz0A:
32.6		 4mxxA-2hz0A:
48.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		7 ALA A 452
GLU A 471
MET A 475
VAL A 484
ILE A 497
GLY A 505
LEU A 553
 4ST  A1687 (-3.3A)
4ST  A1687 ( 4.6A)
None
None
None
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
 0.88A 4mxxA-2j0jA:
32.4		 4mxxA-2j0jA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		7 ALA A 452
LYS A 454
GLU A 471
MET A 475
VAL A 484
ILE A 497
LEU A 553
 4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
None
None
None
4ST  A1687 (-4.4A)
 0.75A 4mxxA-2j0jA:
32.4		 4mxxA-2j0jA:
18.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 251
ALA A 271
GLU A 288
MET A 292
VAL A 301
ILE A 314
THR A 316
TYR A 318
GLY A 322
LEU A 371
 None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.6A)
None
1N8  A 501 ( 4.6A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.7A)
1N8  A 501 ( 3.5A)
1N8  A 501 ( 4.3A)
 0.88A 4mxxA-2og8A:
34.8		 4mxxA-2og8A:
67.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 251
ALA A 271
LYS A 273
GLU A 288
ILE A 314
THR A 316
TYR A 318
GLY A 322
LEU A 371
 None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 4.6A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.7A)
1N8  A 501 ( 3.5A)
1N8  A 501 ( 4.3A)
 0.89A 4mxxA-2og8A:
34.8		 4mxxA-2og8A:
67.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 614
GLU A 633
MET A 637
VAL A 647
THR A 663
TYR A 665
LEU A 785
 None
 0.76A 4mxxA-2ogvA:
29.0		 4mxxA-2ogvA:
34.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 614
GLU A 633
VAL A 647
THR A 663
TYR A 665
GLY A 669
LEU A 785
 None
 0.69A 4mxxA-2ogvA:
29.0		 4mxxA-2ogvA:
34.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qob EPHRIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 651
GLU A 670
MET A 674
ILE A 697
THR A 699
GLY A 705
LEU A 753
 PTR  A 701 ( 4.7A)
None
None
None
None
None
None
 0.71A 4mxxA-2qobA:
28.0		 4mxxA-2qobA:
39.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		8 ALA A 705
GLU A 724
MET A 728
ILE A 751
THR A 753
TYR A 755
GLY A 759
LEU A 807
 None
 0.57A 4mxxA-2r2pA:
34.7		 4mxxA-2r2pA:
43.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 724
ALA A 749
LYS A 751
VAL A 781
THR A 796
GLY A 802
LEU A 850
THR A 860
 GW7  A   1 ( 4.2A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 ( 4.7A)
GW7  A   1 (-4.0A)
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
GW7  A   1 (-3.5A)
 0.92A 4mxxA-2r4bA:
24.8		 4mxxA-2r4bA:
39.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 ALA A 651
LYS A 653
ILE A 697
THR A 699
TYR A 701
GLY A 705
LEU A 753
 Q9G  A1898 (-3.2A)
Q9G  A1898 (-4.8A)
Q9G  A1898 ( 4.6A)
Q9G  A1898 (-3.5A)
Q9G  A1898 (-4.8A)
Q9G  A1898 ( 3.8A)
Q9G  A1898 (-4.3A)
 0.57A 4mxxA-2xyuA:
27.6		 4mxxA-2xyuA:
43.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 ALA A 651
LYS A 653
MET A 674
THR A 699
TYR A 701
GLY A 705
LEU A 753
 Q9G  A1898 (-3.2A)
Q9G  A1898 (-4.8A)
Q9G  A1898 (-3.9A)
Q9G  A1898 (-3.5A)
Q9G  A1898 (-4.8A)
Q9G  A1898 ( 3.8A)
Q9G  A1898 (-4.3A)
 0.73A 4mxxA-2xyuA:
27.6		 4mxxA-2xyuA:
43.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		9 LEU A 253
ALA A 273
LYS A 275
GLU A 290
MET A 294
VAL A 303
ILE A 317
THR A 319
GLY A 325
 None
 0.75A 4mxxA-2zv7A:
37.2		 4mxxA-2zv7A:
64.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		9 LEU A 253
ALA A 273
LYS A 275
MET A 294
VAL A 303
ILE A 317
THR A 319
GLY A 325
LEU A 374
 None
 0.67A 4mxxA-2zv7A:
37.2		 4mxxA-2zv7A:
64.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 515
LYS A 517
GLU A 534
MET A 538
TYR A 566
GLY A 570
LEU A 633
 M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
None
None
M33  A1996 ( 4.7A)
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
 0.84A 4mxxA-3b2tA:
25.5		 4mxxA-3b2tA:
36.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 487
ALA A 515
LYS A 517
MET A 538
TYR A 566
GLY A 570
LEU A 633
 M33  A1996 (-4.0A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
None
M33  A1996 ( 4.7A)
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
 0.83A 4mxxA-3b2tA:
25.5		 4mxxA-3b2tA:
36.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 220
LYS A 222
GLU A 236
MET A 240
VAL A 249
THR A 266
TYR A 268
GLY A 272
LEU A 321
 None
 0.86A 4mxxA-3d7uA:
27.9		 4mxxA-3d7uA:
41.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 220
LYS A 222
GLU A 236
VAL A 249
ILE A 264
THR A 266
TYR A 268
GLY A 272
LEU A 321
 None
 0.77A 4mxxA-3d7uA:
27.9		 4mxxA-3d7uA:
41.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		8 ALA A 663
LYS A 665
GLU A 682
MET A 686
VAL A 695
ILE A 709
GLY A 717
LEU A 765
 IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
IHZ  A1001 ( 4.9A)
None
IHZ  A1001 ( 3.9A)
IHZ  A1001 (-4.6A)
 0.76A 4mxxA-3dkoA:
32.3		 4mxxA-3dkoA:
41.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kex RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 696
LYS A 723
VAL A 753
THR A 768
TYR A 770
GLY A 774
LEU A 822
 ANP  A   1 (-4.4A)
ANP  A   1 (-3.4A)
None
ANP  A   1 ( 4.8A)
ANP  A   1 (-4.3A)
ANP  A   1 ( 4.9A)
ANP  A   1 (-4.7A)
 0.58A 4mxxA-3kexA:
28.0		 4mxxA-3kexA:
32.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 ALA A 665
GLU A 684
MET A 688
THR A 713
TYR A 715
GLY A 719
LEU A 767
 None
None
None
None
GOL  A 403 (-4.1A)
GOL  A 403 (-3.4A)
None
 0.80A 4mxxA-3kulA:
28.8		 4mxxA-3kulA:
38.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		8 ALA A 665
LYS A 667
GLU A 684
ILE A 711
THR A 713
TYR A 715
GLY A 719
LEU A 767
 None
None
None
None
None
GOL  A 403 (-4.1A)
GOL  A 403 (-3.4A)
None
 0.94A 4mxxA-3kulA:
28.8		 4mxxA-3kulA:
38.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		7 ALA A 229
LYS A 231
GLU A 244
THR A 279
TYR A 281
GLY A 285
LEU A 339
 LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
 0.67A 4mxxA-3mdyA:
26.1		 4mxxA-3mdyA:
28.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 227
LYS A 229
GLU A 242
THR A 277
TYR A 279
GLY A 283
LEU A 337
 LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
None
LDN  A 600 (-4.0A)
LDN  A 600 (-4.7A)
LDN  A 600 (-3.3A)
LDN  A 600 (-4.6A)
 0.57A 4mxxA-3my0A:
26.3		 4mxxA-3my0A:
27.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 LEU A 192
ALA A 213
LYS A 215
GLU A 234
VAL A 247
GLY A 269
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
None
AMP  A 577 (-4.8A)
 0.88A 4mxxA-3nyoA:
17.9		 4mxxA-3nyoA:
21.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		7 ALA A 576
LYS A 578
GLU A 596
ILE A 623
THR A 625
TYR A 627
LEU A 683
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-4.3A)
 0.87A 4mxxA-3ppzA:
30.9		 4mxxA-3ppzA:
33.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		8 ALA A 576
LYS A 578
GLU A 596
MET A 600
VAL A 609
THR A 625
TYR A 627
LEU A 683
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-4.3A)
 0.78A 4mxxA-3ppzA:
30.9		 4mxxA-3ppzA:
33.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		7 ALA A 576
LYS A 578
ILE A 623
THR A 625
TYR A 627
GLY A 631
LEU A 683
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.61A 4mxxA-3ppzA:
30.9		 4mxxA-3ppzA:
33.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		8 ALA A 576
LYS A 578
MET A 600
VAL A 609
THR A 625
TYR A 627
GLY A 631
LEU A 683
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.76A 4mxxA-3ppzA:
30.9		 4mxxA-3ppzA:
33.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3s95 LIM DOMAIN KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LYS A 368
GLU A 384
MET A 388
THR A 413
TYR A 415
GLY A 419
LEU A 467
 STU  A   1 (-3.1A)
STU  A   1 (-3.7A)
None
STU  A   1 (-3.9A)
STU  A   1 (-4.7A)
STU  A   1 (-3.6A)
STU  A   1 (-4.6A)
 0.75A 4mxxA-3s95A:
20.3		 4mxxA-3s95A:
34.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 423
ALA A 443
LYS A 445
MET A 464
ILE A 487
THR A 489
TYR A 491
GLY A 495
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
PP2  A   1 ( 4.3A)
PP2  A   1 (-3.6A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.87A 4mxxA-3sxsA:
32.8		 4mxxA-3sxsA:
43.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 423
ALA A 443
LYS A 445
MET A 464
VAL A 473
THR A 489
TYR A 491
GLY A 495
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
PP2  A   1 ( 4.3A)
None
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.86A 4mxxA-3sxsA:
32.8		 4mxxA-3sxsA:
43.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 544
ALA A 570
LYS A 572
VAL A 601
TYR A 619
GLY A 623
LEU A 686
 0F4  A 902 ( 4.2A)
0F4  A 902 (-3.2A)
0F4  A 902 (-4.0A)
None
0F4  A 902 (-4.2A)
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
 0.87A 4mxxA-3v5qA:
25.5		 4mxxA-3v5qA:
35.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  75
ALA A  96
LYS A  98
VAL A 128
ILE A 142
GLY A 150
LEU A 198
 ANP  A 401 (-3.8A)
ANP  A 401 (-3.2A)
ANP  A 401 (-2.7A)
CHU  A 403 (-4.2A)
CHU  A 403 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
 0.82A 4mxxA-3wigA:
22.1		 4mxxA-3wigA:
27.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A1951
ALA A1978
LYS A1980
GLU A1997
MET A2001
ILE A2024
GLY A2032
LEU A2086
 VGH  A3000 ( 4.4A)
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
None
None
None
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
 0.90A 4mxxA-3zbfA:
26.1		 4mxxA-3zbfA:
40.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 649
LYS A 651
GLU A 668
MET A 672
ILE A 695
THR A 697
GLY A 703
LEU A 751
 None
 0.79A 4mxxA-3zfxA:
35.3		 4mxxA-3zfxA:
42.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 121
LYS A 123
GLU A 140
MET A 144
ILE A 167
THR A 169
GLY A 175
LEU A 223
 30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
None
None
30K  A1365 (-3.8A)
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
 0.70A 4mxxA-4aw5A:
27.6		 4mxxA-4aw5A:
42.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  42
ALA A  63
LYS A  65
GLU A  81
VAL A  94
ILE A 108
GLY A 116
LEU A 164
 XZN  A1317 (-3.6A)
XZN  A1317 (-3.5A)
XZN  A1317 (-4.1A)
XZN  A1317 (-3.9A)
XZN  A1317 (-4.4A)
XZN  A1317 (-4.4A)
XZN  A1317 ( 3.7A)
XZN  A1317 (-4.7A)
 1.06A 4mxxA-4bc6A:
22.9		 4mxxA-4bc6A:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		7 ALA A 233
LYS A 235
GLU A 248
THR A 283
TYR A 285
GLY A 289
LEU A 343
 TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
None
TAK  A1507 (-3.6A)
TAK  A1507 ( 4.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
 0.57A 4mxxA-4c02A:
26.4		 4mxxA-4c02A:
27.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 616
ALA A 653
LYS A 655
GLU A 672
MET A 676
THR A 701
TYR A 703
LEU A 773
 None
DI1  A1000 (-3.6A)
DI1  A1000 (-3.9A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.6A)
DI1  A1000 (-4.0A)
DI1  A1000 (-4.5A)
 0.93A 4mxxA-4ckrA:
29.5		 4mxxA-4ckrA:
35.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 377
ALA A 400
LYS A 402
GLU A 420
MET A 424
VAL A 433
GLY A 454
LEU A 501
 0SB  A 701 ( 3.9A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
None
None
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
 0.68A 4mxxA-4f4pA:
32.5		 4mxxA-4f4pA:
36.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A1122
ALA A1148
GLU A1167
VAL A1180
ILE A1194
GLY A1202
LEU A1256
 0UV  A1501 (-3.8A)
0UV  A1501 (-3.4A)
None
0UV  A1501 ( 4.9A)
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
 0.68A 4mxxA-4fodA:
25.3		 4mxxA-4fodA:
34.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 ALA A 880
LYS A 882
GLU A 898
VAL A 911
TYR A 931
GLY A 935
LEU A 983
 IZA  A2001 (-3.4A)
IZA  A2001 ( 4.7A)
None
None
None
IZA  A2001 (-3.3A)
IZA  A2001 ( 4.7A)
 0.72A 4mxxA-4gl9A:
29.5		 4mxxA-4gl9A:
31.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 LEU A 855
LYS A 882
GLU A 898
VAL A 911
TYR A 931
GLY A 935
LEU A 983
 IZA  A2001 (-3.7A)
IZA  A2001 ( 4.7A)
None
None
None
IZA  A2001 (-3.3A)
IZA  A2001 ( 4.7A)
 0.87A 4mxxA-4gl9A:
29.5		 4mxxA-4gl9A:
31.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 853
LYS A 855
GLU A 871
VAL A 884
TYR A 904
GLY A 908
LEU A 956
 19S  A1201 (-3.3A)
19S  A1201 (-3.5A)
None
None
19S  A1201 (-4.7A)
19S  A1201 ( 3.8A)
19S  A1201 (-4.5A)
 0.85A 4mxxA-4hviA:
25.6		 4mxxA-4hviA:
33.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 LEU A 273
ALA A 293
LYS A 295
VAL A 323
ILE A 336
TYR A 340
GLY A 344
LEU A 393
 0J9  A 601 (-4.0A)
0J9  A 601 (-3.3A)
0J9  A 601 ( 4.7A)
None
0J9  A 601 (-4.4A)
0J9  A 601 ( 4.7A)
0J9  A 601 ( 4.1A)
0J9  A 601 (-4.5A)
 0.62A 4mxxA-4k11A:
33.5		 4mxxA-4k11A:
94.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 478
ALA A 506
LYS A 508
GLU A 525
MET A 529
TYR A 557
GLY A 561
LEU A 624
 ACP  A 801 (-3.8A)
ACP  A 801 (-3.3A)
ACP  A 801 (-2.7A)
ACP  A 801 ( 4.8A)
None
None
ACP  A 801 ( 4.6A)
ACP  A 801 (-4.4A)
 0.93A 4mxxA-4k33A:
26.2		 4mxxA-4k33A:
35.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  33
ALA A  54
LYS A  56
GLU A  70
MET A  74
VAL A  83
GLY A 105
LEU A 153
 GOL  A 404 ( 3.6A)
GOL  A 404 ( 3.1A)
GOL  A 403 ( 4.6A)
None
None
GOL  A 403 (-4.1A)
GOL  A 404 (-3.6A)
GOL  A 403 ( 4.4A)
 0.98A 4mxxA-4lg4A:
18.3		 4mxxA-4lg4A:
28.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  33
ALA A  54
LYS A  56
GLU A  70
MET A  74
VAL A  83
TYR A 101
GLY A 105
 GOL  A 404 ( 3.6A)
GOL  A 404 ( 3.1A)
GOL  A 403 ( 4.6A)
None
None
GOL  A 403 (-4.1A)
GOL  A 404 ( 4.9A)
GOL  A 404 (-3.6A)
 0.88A 4mxxA-4lg4A:
18.3		 4mxxA-4lg4A:
28.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  33
ALA A  54
LYS A  56
MET A  74
VAL A  83
ILE A  97
GLY A 105
LEU A 153
 GOL  A 404 ( 3.6A)
GOL  A 404 ( 3.1A)
GOL  A 403 ( 4.6A)
None
GOL  A 403 (-4.1A)
None
GOL  A 404 (-3.6A)
GOL  A 403 ( 4.4A)
 0.87A 4mxxA-4lg4A:
18.3		 4mxxA-4lg4A:
28.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  33
ALA A  54
LYS A  56
MET A  74
VAL A  83
ILE A  97
TYR A 101
GLY A 105
 GOL  A 404 ( 3.6A)
GOL  A 404 ( 3.1A)
GOL  A 403 ( 4.6A)
None
GOL  A 403 (-4.1A)
None
GOL  A 404 ( 4.9A)
GOL  A 404 (-3.6A)
 0.75A 4mxxA-4lg4A:
18.3		 4mxxA-4lg4A:
28.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		8 LEU A 273
ALA A 293
LYS A 295
GLU A 310
MET A 314
ILE A 336
TYR A 340
GLY A 344
 VGG  A 601 (-3.2A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 4.3A)
VGG  A 601 ( 3.6A)
VGG  A 601 (-4.2A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 3.2A)
 0.89A 4mxxA-4lggA:
37.4		 4mxxA-4lggA:
98.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		8 LEU A 273
ALA A 293
LYS A 295
MET A 314
ILE A 336
TYR A 340
GLY A 344
LEU A 393
 VGG  A 601 (-3.2A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 3.6A)
VGG  A 601 (-4.2A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
 0.75A 4mxxA-4lggA:
37.4		 4mxxA-4lggA:
98.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		8 LEU A 273
ALA A 293
MET A 314
VAL A 323
ILE A 336
TYR A 340
GLY A 344
LEU A 393
 VGG  A 601 (-3.2A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 3.6A)
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
 0.61A 4mxxA-4lggA:
37.4		 4mxxA-4lggA:
98.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA B  51
LYS B  53
GLU B  70
ILE B  97
TYR B 101
GLY B 105
LEU B 151
 ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
None
ADP  B 500 ( 4.7A)
None
ADP  B 500 (-4.7A)
 0.82A 4mxxA-4o27B:
20.3		 4mxxA-4o27B:
30.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  46
ALA A  67
LYS A  69
GLU A  85
VAL A  99
THR A 123
GLY A 128
LEU A 180
 SIN  A 401 ( 3.9A)
SIN  A 401 ( 3.7A)
None
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.89A 4mxxA-4o38A:
21.3		 4mxxA-4o38A:
27.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		8 ALA A 644
GLU A 663
MET A 667
ILE A 690
THR A 692
TYR A 694
GLY A 698
LEU A 746
 None
 0.86A 4mxxA-4p2kA:
34.8		 4mxxA-4p2kA:
44.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		11 LEU A  14
ALA A  35
LYS A  37
GLU A  52
MET A  56
VAL A  65
ILE A  79
THR A  81
TYR A  83
GLY A  87
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 (-2.9A)
None
None
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.66A 4mxxA-4ueuA:
36.4		 4mxxA-4ueuA:
62.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 8 LEU B 267
ALA B 288
LYS B 290
MET B 309
VAL B 318
THR B 334
GLY B 340
LEU B 389
 1N1  B 601 (-3.7A)
1N1  B 601 (-3.5A)
1N1  B 601 (-4.6A)
1N1  B 601 (-3.7A)
1N1  B 601 ( 4.3A)
1N1  B 601 (-3.3A)
1N1  B 601 (-3.5A)
1N1  B 601 (-4.3A)
 0.73A 4mxxA-4xeyB:
33.2		 4mxxA-4xeyB:
36.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 8 LEU B 267
ALA B 288
LYS B 290
VAL B 318
ILE B 332
THR B 334
GLY B 340
LEU B 389
 1N1  B 601 (-3.7A)
1N1  B 601 (-3.5A)
1N1  B 601 (-4.6A)
1N1  B 601 ( 4.3A)
1N1  B 601 (-4.1A)
1N1  B 601 (-3.3A)
1N1  B 601 (-3.5A)
1N1  B 601 (-4.3A)
 0.49A 4mxxA-4xeyB:
33.2		 4mxxA-4xeyB:
36.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 LEU A 408
ALA A 428
VAL A 458
ILE A 472
THR A 474
TYR A 476
GLY A 480
LEU A 528
 None
 0.72A 4mxxA-4xi2A:
24.0		 4mxxA-4xi2A:
27.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 616
ALA A 642
LYS A 644
GLU A 661
VAL A 675
TYR A 693
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
None
P30  A1001 ( 4.4A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.87A 4mxxA-4xufA:
29.5		 4mxxA-4xufA:
37.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		8 LEU A 408
ALA A 428
VAL A 458
ILE A 472
THR A 474
TYR A 476
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 (-2.4A)
None
None
746  A 702 (-3.7A)
746  A 702 (-4.4A)
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.60A 4mxxA-4y93A:
31.1		 4mxxA-4y93A:
26.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 625
GLU A 644
MET A 648
VAL A 658
THR A 674
TYR A 676
LEU A 825
 748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 ( 4.8A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 (-4.3A)
 0.85A 4mxxA-5grnA:
24.8		 4mxxA-5grnA:
33.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 625
GLU A 644
VAL A 658
THR A 674
TYR A 676
GLY A 680
LEU A 825
 748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 ( 4.8A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.76A 4mxxA-5grnA:
24.8		 4mxxA-5grnA:
33.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 599
ALA A 625
LYS A 627
GLU A 644
ILE A 672
THR A 674
TYR A 676
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.83A 4mxxA-5grnA:
24.8		 4mxxA-5grnA:
33.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 599
ALA A 625
LYS A 627
GLU A 644
MET A 648
THR A 674
TYR A 676
LEU A 825
 748  A1001 (-3.8A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 (-4.3A)
 0.99A 4mxxA-5grnA:
24.8		 4mxxA-5grnA:
33.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  57
ALA A  77
MET A  99
VAL A 109
TYR A 132
GLY A 136
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-3.6A)
None
None
IDV  A 401 (-3.5A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.87A 4mxxA-5i3oA:
23.3		 4mxxA-5i3oA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  43
LYS A  45
GLU A  61
VAL A  74
ILE A  88
GLY A  96
LEU A 143
 6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
None
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
 0.81A 4mxxA-5j5tA:
22.6		 4mxxA-5j5tA:
24.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 718
ALA A 743
GLU A 762
MET A 766
GLY A 796
LEU A 844
THR A 854
 6HJ  A1101 ( 4.6A)
6HJ  A1101 (-3.1A)
6HJ  A1101 ( 4.2A)
6HJ  A1101 ( 4.1A)
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
6HJ  A1101 (-3.9A)
 0.72A 4mxxA-5j9zA:
32.7		 4mxxA-5j9zA:
33.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 718
ALA A 743
LYS A 745
GLU A 762
GLY A 796
LEU A 844
THR A 854
 6HJ  A1101 ( 4.6A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
6HJ  A1101 ( 4.2A)
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
6HJ  A1101 (-3.9A)
 0.62A 4mxxA-5j9zA:
32.7		 4mxxA-5j9zA:
33.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1

(Homo sapiens) 		PF00069
(Pkinase) 		8 ALA A 297
LYS A 299
GLU A 315
MET A 319
VAL A 328
TYR A 346
LEU A 396
THR A 406
 IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
IPW  A 601 (-3.9A)
IPW  A 601 (-4.1A)
None
IPW  A 601 (-4.5A)
IPW  A 601 (-4.5A)
IPW  A 601 (-3.7A)
 0.62A 4mxxA-5kbrA:
24.0		 4mxxA-5kbrA:
27.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1

(Homo sapiens) 		PF00069
(Pkinase) 		8 ALA A 297
LYS A 299
MET A 319
VAL A 328
TYR A 346
GLY A 350
LEU A 396
THR A 406
 IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
IPW  A 601 (-4.1A)
None
IPW  A 601 (-4.5A)
IPW  A 601 ( 3.8A)
IPW  A 601 (-4.5A)
IPW  A 601 (-3.7A)
 0.65A 4mxxA-5kbrA:
24.0		 4mxxA-5kbrA:
27.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 209
ALA A 228
LYS A 230
GLU A 250
ILE A 281
TYR A 285
GLY A 289
 None
6UY  A 501 (-3.4A)
6UY  A 501 (-4.0A)
6UY  A 501 (-4.3A)
None
6UY  A 501 ( 4.8A)
6UY  A 501 ( 4.3A)
 0.76A 4mxxA-5ko1A:
27.3		 4mxxA-5ko1A:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 209
ALA A 228
LYS A 230
GLU A 250
MET A 254
TYR A 285
GLY A 289
 None
6UY  A 501 (-3.4A)
6UY  A 501 (-4.0A)
6UY  A 501 (-4.3A)
None
6UY  A 501 ( 4.8A)
6UY  A 501 ( 4.3A)
 0.75A 4mxxA-5ko1A:
27.3		 4mxxA-5ko1A:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 209
ALA A 228
LYS A 230
MET A 254
TYR A 285
GLY A 289
LEU A 338
 None
6UY  A 501 (-3.4A)
6UY  A 501 (-4.0A)
None
6UY  A 501 ( 4.8A)
6UY  A 501 ( 4.3A)
6UY  A 501 (-4.5A)
 0.74A 4mxxA-5ko1A:
27.3		 4mxxA-5ko1A:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 7 LEU A  24
ALA A  45
ILE A  93
THR A  95
TYR A  97
GLY A 101
LEU A 153
 9WS  A 401 ( 4.2A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.9A)
9WS  A 401 (-3.2A)
None
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
 0.76A 4mxxA-5w5jA:
23.2		 4mxxA-5w5jA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 8 LEU A 891
ALA A 917
LYS A 919
ILE A 961
THR A 963
TYR A 965
GLY A 969
LEU A1017
 ANP  A1201 (-4.1A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
None
ANP  A1201 (-3.9A)
ANP  A1201 (-4.4A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
 0.74A 4mxxA-5wnoA:
27.9		 4mxxA-5wnoA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 8 LEU A 891
ALA A 917
LYS A 919
THR A 963
TYR A 965
GLY A 969
LEU A1017
THR A1027
 ANP  A1201 (-4.1A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
ANP  A1201 (-3.9A)
ANP  A1201 (-4.4A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
ANP  A1201 ( 4.9A)
 0.80A 4mxxA-5wnoA:
27.9		 4mxxA-5wnoA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 7 ALA A  54
LYS A  56
VAL A  83
ILE A  97
TYR A 101
GLY A 105
LEU A 153
 ANP  A 501 ( 3.7A)
ANP  A 501 (-2.4A)
None
None
ANP  A 501 ( 4.2A)
ANP  A 501 ( 4.0A)
ANP  A 501 (-4.6A)
 0.53A 4mxxA-6ao5A:
22.7		 4mxxA-6ao5A:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 7 LEU A  33
ALA A  54
LYS A  56
VAL A  83
TYR A 101
GLY A 105
LEU A 153
 ANP  A 501 ( 3.8A)
ANP  A 501 ( 3.7A)
ANP  A 501 (-2.4A)
None
ANP  A 501 ( 4.2A)
ANP  A 501 ( 4.0A)
ANP  A 501 (-4.6A)
 0.63A 4mxxA-6ao5A:
22.7		 4mxxA-6ao5A:
24.94