SIMILAR PATTERNS OF AMINO ACIDS FOR 4MXO_A_DB8A601_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k2p TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 428
LYS A 430
VAL A 458
ILE A 472
THR A 474
TYR A 476
GLY A 480
 None
 0.65A 4mxoA-1k2pA:
26.7		 4mxoA-1k2pA:
38.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		11 VAL A 209
ALA A 220
LYS A 222
GLU A 236
MET A 240
VAL A 249
ILE A 264
THR A 266
TYR A 268
GLY A 272
ASP A 332
 None
 0.84A 4mxoA-1k9aA:
33.0		 4mxoA-1k9aA:
30.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		9 LEU A 267
VAL A 275
ALA A 288
LYS A 290
GLU A 305
MET A 309
VAL A 318
ILE A 332
THR A 334
 P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
 0.72A 4mxoA-1opkA:
32.1		 4mxoA-1opkA:
30.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		9 LEU A 267
VAL A 275
ALA A 288
LYS A 290
MET A 309
VAL A 318
ILE A 332
THR A 334
GLY A 340
 P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-3.3A)
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
 0.86A 4mxoA-1opkA:
32.1		 4mxoA-1opkA:
30.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 595
VAL A 603
ALA A 621
LYS A 623
GLU A 640
THR A 670
TYR A 672
GLY A 676
 STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 ( 4.0A)
STI  A   3 ( 3.8A)
 0.88A 4mxoA-1t46A:
31.1		 4mxoA-1t46A:
35.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		12 LEU X  17
VAL X  25
ALA X  37
LYS X  39
GLU X  54
MET X  58
VAL X  67
ILE X  80
THR X  82
TYR X  84
GLY X  88
ASP X 148
 STU  X 902 (-3.8A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
None
None
STU  X 902 (-4.1A)
STU  X 902 (-4.6A)
STU  X 902 (-3.5A)
STU  X 902 (-3.6A)
 0.80A 4mxoA-2dq7X:
37.6		 4mxoA-2dq7X:
84.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		9 LEU A 273
VAL A 281
ALA A 293
LYS A 295
VAL A 323
ILE A 336
THR A 338
TYR A 340
GLY A 344
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
None
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
H8H  A 534 (-4.3A)
H8H  A 534 (-3.3A)
 0.47A 4mxoA-2h8hA:
33.9		 4mxoA-2h8hA:
53.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		9 LEU A 273
VAL A 281
ALA A 293
LYS A 295
VAL A 323
THR A 338
TYR A 340
GLY A 344
ASP A 404
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
None
H8H  A 534 (-3.1A)
H8H  A 534 (-4.3A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.2A)
 0.80A 4mxoA-2h8hA:
33.9		 4mxoA-2h8hA:
53.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 LEU A 273
VAL A 281
ALA A 293
LYS A 295
VAL A 323
ILE A 336
THR A 338
GLY A 344
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
 0.66A 4mxoA-2hckA:
32.5		 4mxoA-2hckA:
51.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 VAL A 643
ALA A 659
GLU A 678
MET A 682
ILE A 705
THR A 707
GLY A 713
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 ( 4.9A)
None
None
ADP  A 400 (-4.7A)
ADP  A 400 ( 4.2A)
 0.56A 4mxoA-2henA:
27.2		 4mxoA-2henA:
41.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		11 LEU A 251
VAL A 259
ALA A 271
LYS A 273
GLU A 288
MET A 292
VAL A 301
ILE A 314
THR A 316
GLY A 322
ASP A 382
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
 0.69A 4mxoA-2hk5A:
29.9		 4mxoA-2hk5A:
67.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 248
VAL A 256
ALA A 269
GLU A 286
MET A 290
VAL A 299
ILE A 313
THR A 315
ASP A 381
 GIN  A 600 ( 4.6A)
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.2A)
GIN  A 600 (-4.6A)
GIN  A 600 (-3.8A)
GIN  A 600 (-3.4A)
GIN  A 600 (-4.9A)
 0.80A 4mxoA-2hz0A:
32.8		 4mxoA-2hz0A:
48.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 248
VAL A 256
ALA A 269
LYS A 271
GLU A 286
ILE A 313
THR A 315
ASP A 381
 GIN  A 600 ( 4.6A)
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.8A)
GIN  A 600 (-3.4A)
GIN  A 600 (-4.9A)
 0.85A 4mxoA-2hz0A:
32.8		 4mxoA-2hz0A:
48.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 248
VAL A 256
ALA A 269
MET A 290
VAL A 299
ILE A 313
THR A 315
GLY A 321
 GIN  A 600 ( 4.6A)
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.2A)
GIN  A 600 (-4.6A)
GIN  A 600 (-3.8A)
GIN  A 600 (-3.4A)
None
 0.94A 4mxoA-2hz0A:
32.8		 4mxoA-2hz0A:
48.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		8 VAL A 436
ALA A 452
LYS A 454
GLU A 471
MET A 475
VAL A 484
ILE A 497
ASP A 564
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
None
None
None
4ST  A1687 (-4.7A)
 0.62A 4mxoA-2j0jA:
32.8		 4mxoA-2j0jA:
18.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 251
ALA A 271
MET A 292
VAL A 301
ILE A 314
THR A 316
TYR A 318
ASP A 382
 None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
None
1N8  A 501 ( 4.6A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.7A)
1N8  A 501 ( 3.3A)
 0.72A 4mxoA-2og8A:
35.5		 4mxoA-2og8A:
67.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 251
VAL A 259
ALA A 271
GLU A 288
MET A 292
VAL A 301
ILE A 314
THR A 316
TYR A 318
 None
None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.6A)
None
1N8  A 501 ( 4.6A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.7A)
 0.40A 4mxoA-2og8A:
35.5		 4mxoA-2og8A:
67.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 251
VAL A 259
ALA A 271
LYS A 273
GLU A 288
ILE A 314
THR A 316
TYR A 318
 None
None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 4.6A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.7A)
 0.65A 4mxoA-2og8A:
35.5		 4mxoA-2og8A:
67.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 251
VAL A 259
ALA A 271
LYS A 273
ILE A 314
THR A 316
TYR A 318
GLY A 322
 None
None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.4A)
1N8  A 501 ( 4.6A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.7A)
1N8  A 501 ( 3.5A)
 0.78A 4mxoA-2og8A:
35.5		 4mxoA-2og8A:
67.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 251
VAL A 259
ALA A 271
MET A 292
VAL A 301
ILE A 314
THR A 316
TYR A 318
GLY A 322
 None
None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
None
1N8  A 501 ( 4.6A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.7A)
1N8  A 501 ( 3.5A)
 0.77A 4mxoA-2og8A:
35.5		 4mxoA-2og8A:
67.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qob EPHRIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 635
ALA A 651
GLU A 670
MET A 674
ILE A 697
THR A 699
GLY A 705
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
None
 0.68A 4mxoA-2qobA:
28.1		 4mxoA-2qobA:
39.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		9 VAL A 689
ALA A 705
GLU A 724
MET A 728
ILE A 751
THR A 753
TYR A 755
GLY A 759
ASP A 818
 None
 0.57A 4mxoA-2r2pA:
35.0		 4mxoA-2r2pA:
43.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A  34
ALA A  47
LYS A  49
GLU A  66
ILE A  93
TYR A  97
GLY A 101
ASP A 158
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
None
J60  A1294 (-4.5A)
J60  A1294 ( 3.8A)
J60  A1294 ( 4.6A)
 0.78A 4mxoA-2xikA:
21.0		 4mxoA-2xikA:
29.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		8 VAL A 635
ALA A 651
LYS A 653
MET A 674
ILE A 697
THR A 699
TYR A 701
GLY A 705
 Q9G  A1898 ( 4.7A)
Q9G  A1898 (-3.2A)
Q9G  A1898 (-4.8A)
Q9G  A1898 (-3.9A)
Q9G  A1898 ( 4.6A)
Q9G  A1898 (-3.5A)
Q9G  A1898 (-4.8A)
Q9G  A1898 ( 3.8A)
 0.61A 4mxoA-2xyuA:
16.2		 4mxoA-2xyuA:
43.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2w WEE1-LIKE PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A 313
ALA A 326
LYS A 328
GLU A 346
VAL A 360
ILE A 374
TYR A 378
ASP A 463
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 (-4.6A)
770  A 901 (-3.9A)
770  A 901 ( 4.7A)
None
770  A 901 (-4.2A)
770  A 901 (-3.8A)
 0.78A 4mxoA-2z2wA:
19.2		 4mxoA-2z2wA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2w WEE1-LIKE PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 313
ALA A 326
VAL A 360
ILE A 374
TYR A 378
GLY A 382
ASP A 463
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 ( 4.7A)
None
770  A 901 (-4.2A)
770  A 901 (-3.4A)
770  A 901 (-3.8A)
 0.69A 4mxoA-2z2wA:
19.2		 4mxoA-2z2wA:
25.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A1002
VAL A1010
ALA A1028
GLU A1047
MET A1051
VAL A1060
GLY A1082
ASP A1150
 S91  A   1 ( 4.1A)
S91  A   1 ( 4.9A)
S91  A   1 (-3.2A)
None
None
None
S91  A   1 (-3.3A)
None
 0.60A 4mxoA-2z8cA:
30.7		 4mxoA-2z8cA:
37.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		10 LEU A 253
VAL A 261
ALA A 273
GLU A 290
MET A 294
VAL A 303
ILE A 317
THR A 319
GLY A 325
ASP A 385
 None
 0.60A 4mxoA-2zv7A:
37.5		 4mxoA-2zv7A:
64.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		10 LEU A 253
VAL A 261
ALA A 273
LYS A 275
GLU A 290
MET A 294
ILE A 317
THR A 319
GLY A 325
ASP A 385
 None
 0.69A 4mxoA-2zv7A:
37.5		 4mxoA-2zv7A:
64.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 495
ALA A 515
LYS A 517
GLU A 534
MET A 538
TYR A 566
GLY A 570
ASP A 644
 M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
None
None
M33  A1996 ( 4.7A)
M33  A1996 ( 4.8A)
M33  A1996 (-4.0A)
 0.85A 4mxoA-3b2tA:
25.7		 4mxoA-3b2tA:
36.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 484
VAL A 492
ALA A 512
LYS A 514
GLU A 531
MET A 535
TYR A 563
ASP A 641
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
None
None
C4F  A   1 ( 3.7A)
None
C4F  A   1 (-4.5A)
 0.84A 4mxoA-3c4fA:
29.6		 4mxoA-3c4fA:
36.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		11 VAL A 209
ALA A 220
LYS A 222
GLU A 236
MET A 240
VAL A 249
ILE A 264
THR A 266
TYR A 268
GLY A 272
ASP A 332
 None
 0.84A 4mxoA-3d7uA:
28.2		 4mxoA-3d7uA:
41.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		8 VAL A 647
ALA A 663
LYS A 665
GLU A 682
MET A 686
VAL A 695
ILE A 709
GLY A 717
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
IHZ  A1001 ( 4.9A)
None
IHZ  A1001 ( 3.9A)
 0.56A 4mxoA-3dkoA:
32.7		 4mxoA-3dkoA:
41.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		7 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  50
MET A  54
TYR A 119
 DRK  A 384 (-3.8A)
None
DRK  A 384 (-3.5A)
None
None
None
DRK  A 384 (-4.4A)
 0.64A 4mxoA-3eb0A:
23.1		 4mxoA-3eb0A:
23.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kex RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 696
VAL A 704
LYS A 723
VAL A 753
THR A 768
TYR A 770
GLY A 774
 ANP  A   1 (-4.4A)
ANP  A   1 (-3.9A)
ANP  A   1 (-3.4A)
None
ANP  A   1 ( 4.8A)
ANP  A   1 (-4.3A)
ANP  A   1 ( 4.9A)
 0.67A 4mxoA-3kexA:
28.1		 4mxoA-3kexA:
33.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		8 VAL A 649
ALA A 665
LYS A 667
ILE A 711
THR A 713
TYR A 715
GLY A 719
ASP A 778
 None
None
None
None
None
GOL  A 403 (-4.1A)
GOL  A 403 (-3.4A)
None
 0.84A 4mxoA-3kulA:
35.1		 4mxoA-3kulA:
38.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		8 VAL A 649
ALA A 665
MET A 688
ILE A 711
THR A 713
TYR A 715
GLY A 719
ASP A 778
 None
None
None
None
None
GOL  A 403 (-4.1A)
GOL  A 403 (-3.4A)
None
 0.74A 4mxoA-3kulA:
35.1		 4mxoA-3kulA:
38.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		8 VAL A 218
ALA A 229
LYS A 231
GLU A 244
THR A 279
TYR A 281
GLY A 285
ASP A 350
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-3.9A)
 0.93A 4mxoA-3mdyA:
26.1		 4mxoA-3mdyA:
28.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		8 ALA A 576
LYS A 578
GLU A 596
MET A 600
VAL A 609
ILE A 623
THR A 625
ASP A 694
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
None
None
STU  A   1 (-4.1A)
STU  A   1 (-3.5A)
 0.94A 4mxoA-3ppzA:
31.1		 4mxoA-3ppzA:
33.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		10 VAL A 565
ALA A 576
LYS A 578
MET A 600
VAL A 609
ILE A 623
THR A 625
TYR A 627
GLY A 631
ASP A 694
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-3.2A)
STU  A   1 (-3.5A)
 0.75A 4mxoA-3ppzA:
31.1		 4mxoA-3ppzA:
33.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3s95 LIM DOMAIN KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 345
LYS A 368
GLU A 384
MET A 388
THR A 413
TYR A 415
GLY A 419
ASP A 478
 STU  A   1 (-3.8A)
STU  A   1 (-3.1A)
STU  A   1 (-3.7A)
None
STU  A   1 (-3.9A)
STU  A   1 (-4.7A)
STU  A   1 (-3.6A)
STU  A   1 ( 4.2A)
 0.80A 4mxoA-3s95A:
26.9		 4mxoA-3s95A:
34.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 423
VAL A 431
ALA A 443
MET A 464
VAL A 473
ILE A 487
THR A 489
TYR A 491
GLY A 495
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
None
PP2  A   1 (-3.6A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
PP2  A   1 ( 4.2A)
 0.73A 4mxoA-3sxsA:
32.8		 4mxoA-3sxsA:
43.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 431
ALA A 443
LYS A 445
MET A 464
VAL A 473
ILE A 487
THR A 489
TYR A 491
 PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
PP2  A   1 ( 4.3A)
None
PP2  A   1 (-3.6A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
 0.89A 4mxoA-3sxsA:
32.8		 4mxoA-3sxsA:
43.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 484
VAL A 492
ALA A 512
LYS A 514
GLU A 531
MET A 535
TYR A 563
 07J  A   1 ( 4.3A)
07J  A   1 (-4.0A)
07J  A   1 (-3.5A)
07J  A   1 (-4.5A)
07J  A   1 (-3.8A)
07J  A   1 (-3.8A)
07J  A   1 (-4.7A)
 0.67A 4mxoA-3tt0A:
30.3		 4mxoA-3tt0A:
33.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  75
VAL A  83
ALA A  96
LYS A  98
VAL A 128
ILE A 142
GLY A 150
 ANP  A 401 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
ANP  A 401 (-2.7A)
CHU  A 403 (-4.2A)
CHU  A 403 (-3.8A)
ANP  A 401 ( 4.3A)
 0.70A 4mxoA-3wigA:
22.1		 4mxoA-3wigA:
27.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 840
VAL A 848
ALA A 866
LYS A 868
GLU A 885
VAL A 899
GLY A 922
ASP A1046
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
None
LEV  A1201 (-3.7A)
None
LEV  A1201 (-3.6A)
GOL  A1210 ( 3.4A)
 0.86A 4mxoA-3wzdA:
30.3		 4mxoA-3wzdA:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A1951
VAL A1959
ALA A1978
LYS A1980
MET A2001
ILE A2024
GLY A2032
ASP A2102
 VGH  A3000 ( 4.4A)
None
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
None
None
VGH  A3000 (-3.5A)
None
 0.64A 4mxoA-3zbfA:
26.4		 4mxoA-3zbfA:
40.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 633
ALA A 649
GLU A 668
MET A 672
ILE A 695
THR A 697
GLY A 703
ASP A 762
 None
 0.58A 4mxoA-3zfxA:
35.4		 4mxoA-3zfxA:
42.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 633
ALA A 649
LYS A 651
GLU A 668
MET A 672
ILE A 695
GLY A 703
ASP A 762
 None
 0.79A 4mxoA-3zfxA:
35.4		 4mxoA-3zfxA:
42.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL A 105
ALA A 121
LYS A 123
GLU A 140
MET A 144
ILE A 167
THR A 169
GLY A 175
ASP A 234
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
None
None
30K  A1365 (-3.8A)
30K  A1365 (-3.5A)
30K  A1365 (-3.3A)
 0.56A 4mxoA-4aw5A:
27.7		 4mxoA-4aw5A:
42.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 616
VAL A 624
ALA A 653
LYS A 655
GLU A 672
MET A 676
THR A 701
TYR A 703
 None
DI1  A1000 (-4.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.9A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.6A)
DI1  A1000 (-4.0A)
 0.75A 4mxoA-4ckrA:
29.7		 4mxoA-4ckrA:
35.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 515
VAL A 523
ALA A 541
VAL A 572
TYR A 590
GLY A 594
ASP A 667
 None
 0.69A 4mxoA-4f0iA:
24.2		 4mxoA-4f0iA:
34.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 377
VAL A 385
ALA A 400
GLU A 420
MET A 424
VAL A 433
GLY A 454
ASP A 512
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
None
None
None
0SB  A 701 (-3.5A)
0SB  A 701 (-3.9A)
 0.54A 4mxoA-4f4pA:
32.8		 4mxoA-4f4pA:
36.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 377
VAL A 385
ALA A 400
LYS A 402
GLU A 420
MET A 424
GLY A 454
ASP A 512
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
None
0SB  A 701 (-3.5A)
0SB  A 701 (-3.9A)
 0.69A 4mxoA-4f4pA:
32.8		 4mxoA-4f4pA:
36.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A1122
VAL A1130
ALA A1148
GLU A1167
VAL A1180
ILE A1194
GLY A1202
ASP A1270
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
None
0UV  A1501 ( 4.9A)
None
0UV  A1501 (-3.6A)
0UV  A1501 ( 4.2A)
 0.76A 4mxoA-4fodA:
25.5		 4mxoA-4fodA:
34.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A1122
VAL A1130
ALA A1148
LYS A1150
GLU A1167
ILE A1194
GLY A1202
ASP A1270
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 (-3.7A)
None
None
0UV  A1501 (-3.6A)
0UV  A1501 ( 4.2A)
 1.12A 4mxoA-4fodA:
25.5		 4mxoA-4fodA:
34.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 LEU A 273
VAL A 281
ALA A 293
LYS A 295
VAL A 323
ILE A 336
TYR A 340
GLY A 344
 0J9  A 601 (-4.0A)
0J9  A 601 (-4.4A)
0J9  A 601 (-3.3A)
0J9  A 601 ( 4.7A)
None
0J9  A 601 (-4.4A)
0J9  A 601 ( 4.7A)
0J9  A 601 ( 4.1A)
 0.57A 4mxoA-4k11A:
33.6		 4mxoA-4k11A:
95.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 478
VAL A 486
ALA A 506
LYS A 508
GLU A 525
MET A 529
TYR A 557
GLY A 561
ASP A 635
 ACP  A 801 (-3.8A)
ACP  A 801 (-4.2A)
ACP  A 801 (-3.3A)
ACP  A 801 (-2.7A)
ACP  A 801 ( 4.8A)
None
None
ACP  A 801 ( 4.6A)
MG  A 802 ( 3.0A)
 0.90A 4mxoA-4k33A:
26.5		 4mxoA-4k33A:
36.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  33
VAL A  41
ALA A  54
GLU A  70
MET A  74
VAL A  83
TYR A 101
GLY A 105
 GOL  A 404 ( 3.6A)
GOL  A 404 (-4.5A)
GOL  A 404 ( 3.1A)
None
None
GOL  A 403 (-4.1A)
GOL  A 404 ( 4.9A)
GOL  A 404 (-3.6A)
 0.78A 4mxoA-4lg4A:
18.4		 4mxoA-4lg4A:
28.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		9 LEU A  33
VAL A  41
ALA A  54
LYS A  56
GLU A  70
MET A  74
TYR A 101
GLY A 105
ASP A 164
 GOL  A 404 ( 3.6A)
GOL  A 404 (-4.5A)
GOL  A 404 ( 3.1A)
GOL  A 403 ( 4.6A)
None
None
GOL  A 404 ( 4.9A)
GOL  A 404 (-3.6A)
GOL  A 403 (-2.4A)
 0.90A 4mxoA-4lg4A:
18.4		 4mxoA-4lg4A:
28.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		9 LEU A  33
VAL A  41
ALA A  54
LYS A  56
MET A  74
ILE A  97
TYR A 101
GLY A 105
ASP A 164
 GOL  A 404 ( 3.6A)
GOL  A 404 (-4.5A)
GOL  A 404 ( 3.1A)
GOL  A 403 ( 4.6A)
None
None
GOL  A 404 ( 4.9A)
GOL  A 404 (-3.6A)
GOL  A 403 (-2.4A)
 0.79A 4mxoA-4lg4A:
18.4		 4mxoA-4lg4A:
28.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  33
VAL A  41
ALA A  54
MET A  74
VAL A  83
ILE A  97
TYR A 101
GLY A 105
 GOL  A 404 ( 3.6A)
GOL  A 404 (-4.5A)
GOL  A 404 ( 3.1A)
None
GOL  A 403 (-4.1A)
None
GOL  A 404 ( 4.9A)
GOL  A 404 (-3.6A)
 0.57A 4mxoA-4lg4A:
18.4		 4mxoA-4lg4A:
28.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		10 LEU A 273
VAL A 281
ALA A 293
LYS A 295
GLU A 310
MET A 314
ILE A 336
TYR A 340
GLY A 344
ASP A 404
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 4.3A)
VGG  A 601 ( 3.6A)
VGG  A 601 (-4.2A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 3.2A)
VGG  A 601 ( 4.7A)
 0.76A 4mxoA-4lggA:
37.8		 4mxoA-4lggA:
98.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		9 LEU A 273
VAL A 281
ALA A 293
MET A 314
VAL A 323
ILE A 336
TYR A 340
GLY A 344
ASP A 404
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 3.6A)
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 3.2A)
VGG  A 601 ( 4.7A)
 0.58A 4mxoA-4lggA:
37.8		 4mxoA-4lggA:
98.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL B  38
ALA B  51
LYS B  53
GLU B  70
ILE B  97
TYR B 101
ASP B 162
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
None
ADP  B 500 ( 4.7A)
ADP  B 500 ( 3.4A)
 0.65A 4mxoA-4o27B:
20.4		 4mxoA-4o27B:
31.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  46
VAL A  54
ALA A  67
GLU A  85
MET A  89
VAL A  99
THR A 123
ASP A 191
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
None
None
None
 0.95A 4mxoA-4o38A:
21.3		 4mxoA-4o38A:
27.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		8 ALA A 644
GLU A 663
MET A 667
ILE A 690
THR A 692
TYR A 694
GLY A 698
ASP A 757
 None
 0.91A 4mxoA-4p2kA:
34.9		 4mxoA-4p2kA:
44.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		8 VAL A 627
ALA A 644
MET A 667
ILE A 690
THR A 692
TYR A 694
GLY A 698
ASP A 757
 None
 0.68A 4mxoA-4p2kA:
34.9		 4mxoA-4p2kA:
44.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		10 LEU A  14
VAL A  22
ALA A  35
GLU A  52
MET A  56
VAL A  65
ILE A  79
THR A  81
GLY A  87
ASP A 147
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
None
 0.66A 4mxoA-4ueuA:
36.7		 4mxoA-4ueuA:
62.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		10 LEU A  14
VAL A  22
ALA A  35
GLU A  52
MET A  56
VAL A  65
ILE A  79
THR A  81
TYR A  83
GLY A  87
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
ACP  A1264 (-3.5A)
 0.57A 4mxoA-4ueuA:
36.7		 4mxoA-4ueuA:
62.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		10 LEU A  14
VAL A  22
ALA A  35
LYS A  37
GLU A  52
MET A  56
ILE A  79
THR A  81
GLY A  87
ASP A 147
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
None
 0.65A 4mxoA-4ueuA:
36.7		 4mxoA-4ueuA:
62.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		10 LEU A  14
VAL A  22
ALA A  35
LYS A  37
GLU A  52
MET A  56
ILE A  79
THR A  81
TYR A  83
GLY A  87
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
ACP  A1264 (-3.5A)
 0.53A 4mxoA-4ueuA:
36.7		 4mxoA-4ueuA:
62.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		9 LEU A  52
VAL A  60
ALA A  72
LYS A  74
GLU A  90
MET A  94
VAL A 104
ILE A 124
ASP A 194
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
None
None
None
None
ZN  A 403 ( 2.6A)
 1.05A 4mxoA-4wsqA:
23.9		 4mxoA-4wsqA:
25.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 9 LEU B 267
VAL B 275
ALA B 288
LYS B 290
MET B 309
VAL B 318
ILE B 332
THR B 334
GLY B 340
 1N1  B 601 (-3.7A)
1N1  B 601 ( 4.9A)
1N1  B 601 (-3.5A)
1N1  B 601 (-4.6A)
1N1  B 601 (-3.7A)
1N1  B 601 ( 4.3A)
1N1  B 601 (-4.1A)
1N1  B 601 (-3.3A)
1N1  B 601 (-3.5A)
 0.66A 4mxoA-4xeyB:
33.6		 4mxoA-4xeyB:
36.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 LEU A 408
VAL A 416
ALA A 428
VAL A 458
ILE A 472
THR A 474
TYR A 476
GLY A 480
 None
 0.64A 4mxoA-4xi2A:
29.9		 4mxoA-4xi2A:
27.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 616
VAL A 624
ALA A 642
LYS A 644
GLU A 661
VAL A 675
TYR A 693
GLY A 697
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
None
P30  A1001 ( 4.4A)
P30  A1001 (-3.5A)
 0.86A 4mxoA-4xufA:
23.9		 4mxoA-4xufA:
37.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		8 LEU A 408
VAL A 416
ALA A 428
VAL A 458
ILE A 472
THR A 474
TYR A 476
GLY A 480
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
None
None
746  A 702 (-3.7A)
746  A 702 (-4.4A)
746  A 702 (-3.6A)
 0.46A 4mxoA-4y93A:
31.1		 4mxoA-4y93A:
26.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 484
VAL A 492
ALA A 512
LYS A 514
GLU A 531
MET A 535
TYR A 563
ASP A 641
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
38O  A1769 (-4.2A)
38O  A1769 (-4.0A)
 0.92A 4mxoA-5a46A:
30.7		 4mxoA-5a46A:
32.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 484
VAL A 492
ALA A 512
LYS A 514
GLU A 531
TYR A 563
GLY A 567
ASP A 641
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
EDO  A1766 (-4.1A)
38O  A1769 (-4.2A)
38O  A1769 (-3.4A)
38O  A1769 (-4.0A)
 0.94A 4mxoA-5a46A:
30.7		 4mxoA-5a46A:
32.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 730
VAL A 738
ALA A 756
LYS A 758
GLU A 775
TYR A 806
GLY A 810
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
PP1  A2012 (-3.5A)
None
PTR  A 809 (-2.4A)
 0.48A 4mxoA-5fm2A:
33.3		 4mxoA-5fm2A:
31.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 599
VAL A 607
ALA A 625
LYS A 627
GLU A 644
MET A 648
ILE A 672
THR A 674
TYR A 676
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
 0.88A 4mxoA-5grnA:
25.0		 4mxoA-5grnA:
33.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 599
VAL A 607
ALA A 625
LYS A 627
ILE A 672
THR A 674
TYR A 676
GLY A 680
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 ( 4.0A)
 0.66A 4mxoA-5grnA:
25.0		 4mxoA-5grnA:
33.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz8 PROTEIN O-MANNOSE
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		8 VAL A  94
ALA A 105
VAL A 134
ILE A 146
THR A 148
TYR A 150
GLY A 154
ASP A 226
 None
 0.80A 4mxoA-5gz8A:
20.1		 4mxoA-5gz8A:
26.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A  30
ALA A  43
LYS A  45
ILE A  80
THR A  82
TYR A  84
GLY A  88
ASP A 151
 032  A 401 (-4.4A)
032  A 401 (-3.2A)
032  A 401 (-4.4A)
032  A 401 (-4.0A)
032  A 401 (-3.7A)
032  A 401 (-4.2A)
032  A 401 ( 4.0A)
032  A 401 (-4.6A)
 0.80A 4mxoA-5hesA:
27.2		 4mxoA-5hesA:
28.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  57
VAL A  65
ALA A  77
MET A  99
VAL A 109
TYR A 132
GLY A 136
ASP A 198
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
None
None
IDV  A 401 (-3.5A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.0A)
 1.04A 4mxoA-5i3oA:
23.3		 4mxoA-5i3oA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A  30
ALA A  43
LYS A  45
GLU A  61
MET A  65
VAL A  74
ILE A  88
ASP A 154
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
None
None
6G2  A 901 (-3.4A)
 0.85A 4mxoA-5j5tA:
22.7		 4mxoA-5j5tA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A  30
ALA A  43
LYS A  45
MET A  65
VAL A  74
ILE A  88
GLY A  96
ASP A 154
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
None
6G2  A 901 (-3.6A)
6G2  A 901 (-3.4A)
 0.83A 4mxoA-5j5tA:
22.7		 4mxoA-5j5tA:
24.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 718
VAL A 726
ALA A 743
LYS A 745
GLU A 762
MET A 766
GLY A 796
ASP A 855
 6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
6HJ  A1101 ( 4.2A)
6HJ  A1101 ( 4.1A)
6HJ  A1101 ( 4.5A)
6HJ  A1101 (-4.3A)
 0.72A 4mxoA-5j9zA:
32.7		 4mxoA-5j9zA:
32.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 284
ALA A 297
LYS A 299
MET A 319
VAL A 328
TYR A 346
GLY A 350
 IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
IPW  A 601 (-4.1A)
None
IPW  A 601 (-4.5A)
IPW  A 601 ( 3.8A)
 0.64A 4mxoA-5kbrA:
24.0		 4mxoA-5kbrA:
26.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 209
ALA A 228
LYS A 230
GLU A 250
MET A 254
ILE A 281
TYR A 285
GLY A 289
 None
6UY  A 501 (-3.4A)
6UY  A 501 (-4.0A)
6UY  A 501 (-4.3A)
None
None
6UY  A 501 ( 4.8A)
6UY  A 501 ( 4.3A)
 0.58A 4mxoA-5ko1A:
27.1		 4mxoA-5ko1A:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis) 		no annotation 8 LEU A  17
VAL A  25
ALA A  38
LYS A  40
GLU A  59
ILE A  90
TYR A  94
ASP A 156
 G93  A 301 ( 3.8A)
G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
G93  A 301 (-3.0A)
G93  A 301 (-3.2A)
G93  A 301 ( 3.8A)
None
G93  A 301 ( 3.2A)
 0.83A 4mxoA-5u94A:
26.9		 4mxoA-5u94A:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A 116
VAL A 124
ALA A 137
LYS A 139
GLU A 157
VAL A 171
THR A 187
ASP A 251
 H8H  A 401 (-3.7A)
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-4.9A)
None
None
H8H  A 401 (-3.5A)
EDO  A 402 ( 2.9A)
 0.85A 4mxoA-5vcxA:
19.7		 4mxoA-5vcxA:
26.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vdk WEE1-LIKE PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 226
ALA A 239
VAL A 273
ILE A 287
TYR A 291
GLY A 295
ASP A 380
 8X7  A 501 ( 4.5A)
8X7  A 501 ( 3.7A)
8X7  A 501 ( 4.6A)
PO4  A 502 (-3.4A)
8X7  A 501 (-4.2A)
8X7  A 501 (-3.6A)
8X7  A 501 (-4.8A)
 0.66A 4mxoA-5vdkA:
18.1		 4mxoA-5vdkA:
26.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 7 LEU A  24
VAL A  32
ALA A  45
ILE A  93
THR A  95
TYR A  97
GLY A 101
 9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.9A)
9WS  A 401 (-3.2A)
None
9WS  A 401 ( 4.3A)
 0.66A 4mxoA-5w5jA:
23.3		 4mxoA-5w5jA:
28.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 7 VAL A  32
ALA A  45
LYS A  47
ILE A  93
THR A  95
TYR A  97
GLY A 101
 9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.9A)
9WS  A 401 (-3.2A)
None
9WS  A 401 ( 4.3A)
 0.67A 4mxoA-5w5jA:
23.3		 4mxoA-5w5jA:
28.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 8 LEU A 891
VAL A 899
ALA A 917
LYS A 919
ILE A 961
THR A 963
TYR A 965
GLY A 969
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
None
ANP  A1201 (-3.9A)
ANP  A1201 (-4.4A)
ANP  A1201 ( 4.6A)
 0.64A 4mxoA-5wnoA:
27.9		 4mxoA-5wnoA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 7 LEU A  33
VAL A  41
ALA A  54
VAL A  83
ILE A  97
TYR A 101
GLY A 105
 ANP  A 501 ( 3.8A)
ANP  A 501 (-4.4A)
ANP  A 501 ( 3.7A)
None
None
ANP  A 501 ( 4.2A)
ANP  A 501 ( 4.0A)
 0.47A 4mxoA-6ao5A:
22.7		 4mxoA-6ao5A:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 7 VAL A  41
ALA A  54
LYS A  56
VAL A  83
ILE A  97
TYR A 101
GLY A 105
 ANP  A 501 (-4.4A)
ANP  A 501 ( 3.7A)
ANP  A 501 (-2.4A)
None
None
ANP  A 501 ( 4.2A)
ANP  A 501 ( 4.0A)
 0.56A 4mxoA-6ao5A:
22.7		 4mxoA-6ao5A:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 8 LEU A 881
VAL A 889
ALA A 906
LYS A 908
GLU A 925
VAL A 938
GLY A 962
ASP A1021
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
None
ADP  A1201 ( 4.1A)
MG  A1203 (-1.8A)
 0.87A 4mxoA-6c7yA:
29.6		 4mxoA-6c7yA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1

(Homo sapiens) 		no annotation 7 LEU A 167
VAL A 175
ALA A 189
LYS A 191
GLU A 206
ILE A 239
GLY A 245
 EAQ  A 501 (-3.9A)
None
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.2A)
EAQ  A 501 (-3.4A)
None
EAQ  A 501 (-3.9A)
 0.64A 4mxoA-6fyoA:
24.0		 4mxoA-6fyoA:
undetectable