SIMILAR PATTERNS OF AMINO ACIDS FOR 4MWZ_B_CQAB303_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fob BETA-1,4-GALACTANASE

(Aspergillus
aculeatus) 		PF07745
(Glyco_hydro_53) 		5 GLY A  40
ILE A  35
GLU A 323
LEU A  25
GLU A 329
 None
 1.45A 4mwzB-1fobA:
0.5		 4mwzB-1fobA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hcu ALPHA-1,2-MANNOSIDAS
E

(Trichoderma
reesei) 		PF01532
(Glyco_hydro_47) 		4 GLY A 314
GLY A 319
ILE A 321
LEU A 256
 None
 0.68A 4mwzB-1hcuA:
0.0		 4mwzB-1hcuA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jy2 FIBRINOGEN ALPHA
CHAIN
FIBRINOGEN GAMMA-B
CHAIN

(Bos taurus;
Bos taurus) 		PF08702
(Fib_alpha)
PF08702
(Fib_alpha) 		4 ILE N  69
LEU P  40
LEU P  43
GLU P  44
 None
 0.50A 4mwzB-1jy2N:
undetectable		 4mwzB-1jy2N:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE

(Saccharomyces
cerevisiae) 		PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5) 		4 GLY A 318
ILE A 293
LEU A 488
LEU A 321
 None
None
None
NAD  A 900 (-4.3A)
 0.70A 4mwzB-1la2A:
0.0		 4mwzB-1la2A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oa1 HYDROXYLAMINE
REDUCTASE

(Desulfovibrio
vulgaris) 		PF03063
(Prismane) 		4 GLY A  45
ILE A  41
LEU A 180
LEU A 183
 None
 0.83A 4mwzB-1oa1A:
0.7		 4mwzB-1oa1A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhb HALOPEROXIDASE

(Corallina
officinalis) 		PF01569
(PAP2) 		4 GLY A  55
ILE A  54
LEU A 150
GLU A  39
 None
 0.80A 4mwzB-1qhbA:
0.0		 4mwzB-1qhbA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rx0 ACYL-COA
DEHYDROGENASE FAMILY
MEMBER 8,
MITOCHONDRIAL

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 GLY A  63
GLY A  74
ILE A  69
LEU A 127
 None
 0.85A 4mwzB-1rx0A:
0.0		 4mwzB-1rx0A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t0a 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Shewanella
oneidensis) 		PF02542
(YgbB) 		4 GLY A  72
GLY A  39
ILE A  21
LEU A  43
 None
 0.84A 4mwzB-1t0aA:
0.0		 4mwzB-1t0aA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vdw HYPOTHETICAL PROTEIN
PH1897

(Pyrococcus
horikoshii) 		PF00459
(Inositol_P) 		4 GLY A 127
GLY A 205
LEU A 179
LEU A 182
 None
 0.72A 4mwzB-1vdwA:
0.1		 4mwzB-1vdwA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x77 CONSERVED
HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF03358
(FMN_red) 		4 GLY A 122
GLY A 115
ILE A 149
LEU A 114
 None
 0.77A 4mwzB-1x77A:
1.0		 4mwzB-1x77A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xi6 EXTRAGENIC
SUPPRESSOR

(Pyrococcus
furiosus) 		PF00459
(Inositol_P) 		4 GLY A 127
GLY A 206
LEU A 180
LEU A 183
 None
 0.65A 4mwzB-1xi6A:
undetectable		 4mwzB-1xi6A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xi6 EXTRAGENIC
SUPPRESSOR

(Pyrococcus
furiosus) 		PF00459
(Inositol_P) 		4 GLY A 190
LEU A 173
LEU A 178
GLU A 179
 None
 0.82A 4mwzB-1xi6A:
undetectable		 4mwzB-1xi6A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zc6 PROBABLE
N-ACETYLGLUCOSAMINE
KINASE

(Chromobacterium
violaceum) 		PF01869
(BcrAD_BadFG) 		4 GLY A  82
GLY A  15
LEU A 288
LEU A 289
 None
 0.82A 4mwzB-1zc6A:
undetectable		 4mwzB-1zc6A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy8 DIHYDROLIPOYL
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 GLY A 293
GLY A 288
ILE A 121
GLU A 291
 None
 0.84A 4mwzB-1zy8A:
undetectable		 4mwzB-1zy8A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b24 NAPHTHALENE
DIOXYGENASE LARGE
SUBUNIT

(Rhodococcus sp.
NCIMB 12038) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 GLY A 367
GLY A 363
ILE A 364
GLU A 369
 None
 0.77A 4mwzB-2b24A:
undetectable		 4mwzB-2b24A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bdq COPPER HOMEOSTASIS
PROTEIN CUTC

(Streptococcus
agalactiae) 		PF03932
(CutC) 		4 GLY A 158
GLY A 185
ILE A 161
LEU A 152
 None
 0.78A 4mwzB-2bdqA:
undetectable		 4mwzB-2bdqA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0k OXIDOREDUCTASE

(Brevibacterium
sterolicum) 		PF01565
(FAD_binding_4)
PF09129
(Chol_subst-bind) 		4 GLY A 148
GLY A 165
ILE A 193
LEU A 263
 None
None
None
FAD  A 700 (-4.0A)
 0.76A 4mwzB-2i0kA:
undetectable		 4mwzB-2i0kA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgr YEGS

(Escherichia
coli) 		PF00781
(DAGK_cat) 		4 GLY A 219
ILE A 124
LEU A 298
LEU A 297
 None
 0.73A 4mwzB-2jgrA:
undetectable		 4mwzB-2jgrA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lba BABP PROTEIN

(Gallus gallus) 		PF14651
(Lipocalin_7) 		4 GLY A  87
ILE A  90
GLU A 110
GLU A 102
 None
CHO  A 201 ( 4.2A)
CHO  A 201 (-3.7A)
None
 0.85A 4mwzB-2lbaA:
undetectable		 4mwzB-2lbaA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mlg SULFOLOBUS
TRANSCRIPTION FACTOR
76 AMINOACID
PROTEIN, STF76

(Fuselloviridae) 		PF05584
(Sulfolobus_pRN) 		4 GLU A  73
LEU A  74
LEU A  77
GLU A  78
 None
 0.63A 4mwzB-2mlgA:
undetectable		 4mwzB-2mlgA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1r LIPID KINASE YEGS

(Salmonella
enterica) 		PF00781
(DAGK_cat) 		4 GLY A 219
ILE A 124
LEU A 298
LEU A 297
 CA  A 301 ( 4.8A)
None
None
None
 0.72A 4mwzB-2p1rA:
undetectable		 4mwzB-2p1rA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbk KSHV PROTEASE

(Human
gammaherpesvirus
8) 		PF00716
(Peptidase_S21) 		4 GLY A   8
ILE A  71
LEU A 106
LEU A 110
 None
 0.78A 4mwzB-2pbkA:
undetectable		 4mwzB-2pbkA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF16073
(SAT) 		4 GLY B 505
LEU B 176
LEU B 173
GLU B 172
 None
 0.81A 4mwzB-2pffB:
undetectable		 4mwzB-2pffB:
6.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q4v DIAMINE
ACETYLTRANSFERASE 2

(Homo sapiens) 		PF00583
(Acetyltransf_1) 		4 GLY A 106
GLY A  73
GLU A  23
LEU A  20
 ACO  A 306 (-3.2A)
None
None
None
 0.79A 4mwzB-2q4vA:
undetectable		 4mwzB-2q4vA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ru4 ARMADILLO REPEAT
PROTEIN, N-TERMINAL
FRAGMENT, YIIM2

(synthetic
construct) 		PF00514
(Arm) 		4 GLY A  73
GLY A  32
ILE A  36
GLU A  34
 None
 0.77A 4mwzB-2ru4A:
undetectable		 4mwzB-2ru4A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8v CLASS III CHITINASE,
PUTATIVE

(Aspergillus
fumigatus) 		PF00704
(Glyco_hydro_18) 		4 GLY A 126
ILE A  45
GLU A  75
LEU A  79
 None
 0.78A 4mwzB-2y8vA:
undetectable		 4mwzB-2y8vA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yky BETA-TRANSAMINASE

(Mesorhizobium
sp. LUK) 		PF00202
(Aminotran_3) 		4 GLY A 227
GLY A 413
ILE A 374
LEU A 409
 None
 0.76A 4mwzB-2ykyA:
undetectable		 4mwzB-2ykyA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aty PROSTAGLANDIN F2A
SYNTHASE

(Trypanosoma
cruzi) 		PF00724
(Oxidored_FMN) 		4 GLY A 199
GLY A 255
ILE A 260
LEU A 253
 None
 0.81A 4mwzB-3atyA:
undetectable		 4mwzB-3atyA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bw2 2-NITROPROPANE
DIOXYGENASE

(Streptomyces
ansochromogenes) 		PF03060
(NMO) 		4 GLY A 322
ILE A 217
LEU A 196
GLU A 175
 FMN  A 370 (-3.4A)
None
None
None
 0.81A 4mwzB-3bw2A:
undetectable		 4mwzB-3bw2A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cih PUTATIVE
ALPHA-RHAMNOSIDASE

(Bacteroides
thetaiotaomicron) 		PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		4 GLY A 656
GLU A 563
LEU A 564
LEU A 567
 None
 0.76A 4mwzB-3cihA:
undetectable		 4mwzB-3cihA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cng NUDIX HYDROLASE

(Nitrosomonas
europaea) 		PF00293
(NUDIX)
PF14803
(Nudix_N_2) 		4 GLY A  81
GLY A  42
ILE A  40
LEU A 114
 None
None
GOL  A 501 (-4.8A)
None
 0.84A 4mwzB-3cngA:
undetectable		 4mwzB-3cngA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ds8 LIN2722 PROTEIN

(Listeria
innocua) 		PF06028
(DUF915) 		4 GLY A 105
GLY A 131
ILE A 177
LEU A 225
 None
 0.79A 4mwzB-3ds8A:
undetectable		 4mwzB-3ds8A:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3err FUSION PROTEIN OF
MICROTUBULE BINDING
DOMAIN FROM MOUSE
CYTOPLASMIC DYNEIN
AND SERYL-TRNA
SYNTHETASE FROM
THERMUS THERMOPHILUS

(Thermus
thermophilus;
Mus musculus) 		PF00587
(tRNA-synt_2b)
PF12777
(MT) 		4 GLU A3413
LEU A3414
LEU A3417
GLU A3418
 None
 0.71A 4mwzB-3errA:
undetectable		 4mwzB-3errA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f6m 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Yersinia pestis) 		PF02542
(YgbB) 		4 GLY A  72
GLY A  39
ILE A  21
LEU A  43
 None
 0.79A 4mwzB-3f6mA:
undetectable		 4mwzB-3f6mA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1w SUGAR ABC
TRANSPORTER

(Bacillus
halodurans) 		PF13407
(Peripla_BP_4) 		4 GLY A 102
ILE A 127
LEU A 292
LEU A 295
 None
 0.82A 4mwzB-3g1wA:
undetectable		 4mwzB-3g1wA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3l ALKYLHALIDASE CMLS

(Streptomyces
venezuelae) 		PF04820
(Trp_halogenase) 		4 GLY A  15
GLY A 164
ILE A   9
LEU A 292
 None
FAD  A 600 (-3.4A)
FAD  A 600 ( 4.9A)
None
 0.79A 4mwzB-3i3lA:
undetectable		 4mwzB-3i3lA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9e VP5

(Bluetongue
virus) 		PF00901
(Orbi_VP5) 		4 GLY D 254
GLY D 249
GLU D 164
LEU D 237
 None
 0.77A 4mwzB-3j9eD:
undetectable		 4mwzB-3j9eD:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k5w CARBOHYDRATE KINASE

(Helicobacter
pylori) 		PF01256
(Carb_kinase)
PF03853
(YjeF_N) 		4 GLY A 155
ILE A 123
GLU A 132
LEU A 135
 None
PO4  A 501 (-4.7A)
None
None
 0.81A 4mwzB-3k5wA:
undetectable		 4mwzB-3k5wA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxy EXOENZYME S
SYNTHESIS PROTEIN C

(Pseudomonas
aeruginosa) 		PF05932
(CesT) 		4 GLY A  87
LEU A  53
LEU A  54
GLU A  55
 None
 0.85A 4mwzB-3kxyA:
undetectable		 4mwzB-3kxyA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6c SERINE RACEMASE

(Rattus
norvegicus) 		PF00291
(PALP) 		4 GLY A 192
GLY A 187
ILE A 252
GLU A 210
 None
PLP  A 350 (-3.3A)
None
MN  A 340 (-3.0A)
 0.80A 4mwzB-3l6cA:
undetectable		 4mwzB-3l6cA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6e OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY

(Aeromonas
hydrophila) 		PF00106
(adh_short) 		4 GLY A  76
GLY A   4
LEU A  80
GLU A  79
 None
 0.75A 4mwzB-3l6eA:
undetectable		 4mwzB-3l6eA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lku UPF0363 PROTEIN
YOR164C

(Saccharomyces
cerevisiae) 		PF04190
(DUF410) 		4 GLY A  72
ILE A  76
LEU A  64
LEU A  61
 None
 0.72A 4mwzB-3lkuA:
undetectable		 4mwzB-3lkuA:
26.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE

(Shigella
flexneri) 		PF00145
(DNA_methylase) 		4 GLY A 371
LEU A 314
LEU A 313
GLU A 406
 None
 0.82A 4mwzB-3me5A:
undetectable		 4mwzB-3me5A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmt FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Bartonella
henselae) 		PF00274
(Glycolytic) 		4 GLY A  18
GLY A  16
LEU A 331
LEU A 328
 None
 0.75A 4mwzB-3mmtA:
undetectable		 4mwzB-3mmtA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmw ENDOGLUCANASE

(Thermotoga
maritima) 		PF00150
(Cellulase) 		4 GLY A  19
ILE A  18
LEU A  22
GLU A  23
 None
 0.81A 4mwzB-3mmwA:
undetectable		 4mwzB-3mmwA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ow2 50S RIBOSOMAL
PROTEIN L2P

(Haloarcula
marismortui) 		PF00181
(Ribosomal_L2)
PF03947
(Ribosomal_L2_C) 		4 GLY A 157
ILE A  88
GLU A  98
LEU A  94
 None
 0.78A 4mwzB-3ow2A:
undetectable		 4mwzB-3ow2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3owc PROBABLE
ACETYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00583
(Acetyltransf_1) 		4 GLY A 181
LEU A 110
LEU A 113
GLU A 114
 None
 0.82A 4mwzB-3owcA:
undetectable		 4mwzB-3owcA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3owc PROBABLE
ACETYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00583
(Acetyltransf_1) 		4 GLY A 182
LEU A 110
LEU A 113
GLU A 114
 None
 0.82A 4mwzB-3owcA:
undetectable		 4mwzB-3owcA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pt8 HEMOGLOBIN III

(Phacoides
pectinatus) 		PF00042
(Globin) 		4 GLY B 127
LEU B 116
LEU B 119
GLU B 120
 None
 0.64A 4mwzB-3pt8B:
undetectable		 4mwzB-3pt8B:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s8d COENZYME A
TRANSFERASE

(Yersinia pestis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		4 GLY A 330
ILE A 380
GLU A 429
LEU A 430
 None
 0.84A 4mwzB-3s8dA:
undetectable		 4mwzB-3s8dA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3twk FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE 1

(Arabidopsis
thaliana) 		PF01149
(Fapy_DNA_glyco)
PF06831
(H2TH) 		4 GLY A 147
GLY A  59
GLU A   8
LEU A 151
 None
 0.74A 4mwzB-3twkA:
undetectable		 4mwzB-3twkA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufc PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF01881
(Cas_Cas6) 		4 GLY X 103
ILE X  16
LEU X  24
GLU X  23
 None
 0.80A 4mwzB-3ufcX:
undetectable		 4mwzB-3ufcX:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x17 ENDOGLUCANASE

(uncultured
bacterium) 		no annotation 4 GLY B 409
GLY B 370
GLU B 323
LEU B 365
 None
 0.83A 4mwzB-3x17B:
undetectable		 4mwzB-3x17B:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyv AOX3

(Mus musculus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 GLY A  86
ILE A  11
GLU A 221
LEU A 222
 None
 0.74A 4mwzB-3zyvA:
undetectable		 4mwzB-3zyvA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4azw WBDD

(Escherichia
coli) 		PF00069
(Pkinase)
PF13847
(Methyltransf_31) 		4 GLY A 192
ILE A 158
LEU A 128
GLU A 160
 None
None
SAM  A1451 (-4.1A)
None
 0.85A 4mwzB-4azwA:
undetectable		 4mwzB-4azwA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5

(Homo sapiens) 		PF01979
(Amidohydro_1) 		4 GLY A 212
ILE A 218
GLU A 204
LEU A 208
 None
 0.82A 4mwzB-4b92A:
undetectable		 4mwzB-4b92A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dbh 2-HYDROXYHEPTA-2,4-D
IENE-1,7-DIOATE
ISOMERASE

(Corynebacterium
glutamicum) 		PF01557
(FAA_hydrolase)
PF10370
(DUF2437) 		4 GLY A  99
GLY A 170
ILE A 145
GLU A 116
 None
None
None
MG  A 401 ( 2.9A)
 0.85A 4mwzB-4dbhA:
undetectable		 4mwzB-4dbhA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl3 PUTATIVE
GLUCOAMYLASE

(Bacteroides
uniformis) 		PF10091
(Glycoamylase) 		4 GLY A  85
GLY A  80
ILE A 404
GLU A 220
 None
None
TRS  A 500 (-4.5A)
TRS  A 500 (-4.1A)
 0.81A 4mwzB-4gl3A:
undetectable		 4mwzB-4gl3A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxb SORTING NEXIN-17

(Homo sapiens) 		no annotation 4 GLY A 340
GLY A 332
LEU A 329
GLU A 343
 None
 0.73A 4mwzB-4gxbA:
undetectable		 4mwzB-4gxbA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hka TRYPTOPHAN
2,3-DIOXYGENASE

(Drosophila
melanogaster) 		PF03301
(Trp_dioxygenase) 		4 GLY A 198
GLY A 275
ILE A 279
LEU A 193
 None
 0.83A 4mwzB-4hkaA:
undetectable		 4mwzB-4hkaA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ihe THNT PROTEIN

(Streptomyces
cattleya) 		PF03576
(Peptidase_S58) 		4 GLY A 187
GLY A 183
ILE A 197
LEU A 100
 None
 0.73A 4mwzB-4iheA:
undetectable		 4mwzB-4iheA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jza UNCHARACTERIZED
PROTEIN

(Legionella
longbeachae) 		no annotation 4 GLY A  29
ILE A   5
LEU A  23
GLU A  24
 None
 0.84A 4mwzB-4jzaA:
undetectable		 4mwzB-4jzaA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mru SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		4 GLY A  82
GLY A  79
LEU A 465
LEU A 466
 None
None
EDO  A 605 ( 3.8A)
None
 0.82A 4mwzB-4mruA:
undetectable		 4mwzB-4mruA:
19.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE

(Plasmodium
vivax) 		PF13649
(Methyltransf_25) 		7 GLY A  29
GLY A  36
ILE A  39
GLU A 209
LEU A 210
GLU A 214
LYS A 217
 None
 0.36A 4mwzB-4mwzA:
undetectable		 4mwzB-4mwzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE

(Plasmodium
vivax) 		PF13649
(Methyltransf_25) 		4 GLY A  36
LEU A 210
LEU A 213
GLU A 214
 None
 0.61A 4mwzB-4mwzA:
undetectable		 4mwzB-4mwzA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nee AP-2 COMPLEX SUBUNIT
ALPHA-2

(Rattus
norvegicus) 		no annotation 4 GLY G  94
GLU G 107
LEU G 108
LEU G 111
 None
 0.65A 4mwzB-4neeG:
undetectable		 4mwzB-4neeG:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLY B 103
GLY B 156
LEU B 284
LEU B 287
 None
 0.76A 4mwzB-4o27B:
undetectable		 4mwzB-4o27B:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p15 BACILLUS LEHENSIS
CLPC N-TERMINAL
DOMAIN

(Bacillus
lehensis) 		PF02861
(Clp_N) 		5 GLY A  44
GLY A 104
ILE A 108
LEU A 110
GLU A 106
 SO4  A 202 (-3.2A)
SO4  A 202 (-3.4A)
None
None
SO4  A 202 (-2.9A)
 1.25A 4mwzB-4p15A:
undetectable		 4mwzB-4p15A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4plf LACTATE
DEHYDROGENASE

(Apicomplexa) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 GLY A  85
GLY A  17
ILE A  19
LEU A  13
 NAI  A 401 (-4.0A)
NAI  A 401 (-3.3A)
NAI  A 401 (-3.7A)
None
 0.76A 4mwzB-4plfA:
undetectable		 4mwzB-4plfA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4plh MALATE DEHYDROGENASE

(Apicomplexa) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 GLY A  81
GLY A  13
ILE A  15
LEU A   9
 NAI  A 403 (-4.3A)
NA  A 402 ( 3.3A)
NAI  A 403 ( 3.8A)
None
 0.70A 4mwzB-4plhA:
undetectable		 4mwzB-4plhA:
21.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE

(Plasmodium
falciparum) 		PF13649
(Methyltransf_25) 		4 GLY A  32
GLY A  39
LEU A 213
GLU A 217
 None
 0.48A 4mwzB-4r6wA:
undetectable		 4mwzB-4r6wA:
63.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE

(Plasmodium
falciparum) 		PF13649
(Methyltransf_25) 		4 GLY A  39
LEU A 213
GLU A 217
LYS A 219
 None
 0.78A 4mwzB-4r6wA:
undetectable		 4mwzB-4r6wA:
63.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ubs PENTALENIC ACID
SYNTHASE

(Streptomyces
avermitilis) 		PF00067
(p450) 		4 GLY A 211
GLU A 230
LEU A 231
LEU A 234
 None
 0.60A 4mwzB-4ubsA:
undetectable		 4mwzB-4ubsA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ayh CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Mus musculus) 		PF12777
(MT) 		4 GLU A3413
LEU A3414
LEU A3417
GLU A3418
 None
 0.65A 4mwzB-5ayhA:
undetectable		 4mwzB-5ayhA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cx7 ATP:COB(I)ALAMIN
ADENOSYLTRANSFERASE

(Salmonella
enterica) 		PF03928
(Haem_degrading) 		4 GLY A  44
GLY A 119
ILE A  39
LEU A 110
 None
 0.72A 4mwzB-5cx7A:
undetectable		 4mwzB-5cx7A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9a POLYMERASE BASIC
PROTEIN 2

(Influenza C
virus) 		PF00604
(Flu_PB2) 		4 GLY C 332
LEU C 341
LEU C 342
LYS C 344
 None
 0.69A 4mwzB-5d9aC:
undetectable		 4mwzB-5d9aC:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ep8 PYRIMIDINE-NUCLEOSID
E PHOSPHORYLASE

(Bacillus
subtilis) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		4 GLY A  88
LEU A 251
GLU A 252
LYS A 254
 GLY  A  88 ( 0.0A)
LEU  A 251 ( 0.6A)
GLU  A 252 ( 0.6A)
LYS  A 254 ( 0.0A)
 0.62A 4mwzB-5ep8A:
undetectable		 4mwzB-5ep8A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g2x GROUP II
INTRON-ENCODED
PROTEIN LTRA

(Lactococcus
lactis) 		PF00078
(RVT_1)
PF01348
(Intron_maturas2) 		4 GLY C 210
GLY C 214
LEU C 217
LEU C 221
 None
 0.84A 4mwzB-5g2xC:
undetectable		 4mwzB-5g2xC:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i92 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Pseudomonas
aeruginosa) 		PF00202
(Aminotran_3) 		4 GLY A 270
ILE A 267
LEU A 312
LEU A 309
 None
 0.84A 4mwzB-5i92A:
undetectable		 4mwzB-5i92A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ir2 CELLULASE

(Parabacteroides
johnsonii) 		PF03737
(RraA-like) 		4 GLY A 197
ILE A 194
LEU A  38
GLU A  42
 None
 0.84A 4mwzB-5ir2A:
undetectable		 4mwzB-5ir2A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ivl DEAD-BOX
ATP-DEPENDENT RNA
HELICASE CSHA

(Geobacillus
stearothermophilus) 		no annotation 4 GLY B 377
LEU B 419
LEU B 422
GLU B 423
 None
 0.73A 4mwzB-5ivlB:
undetectable		 4mwzB-5ivlB:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjc CYSTEINE SYNTHASE

(Brucella
abortus) 		PF00291
(PALP) 		4 GLY A 276
ILE A 282
GLU A 270
LEU A 272
 None
 0.84A 4mwzB-5jjcA:
undetectable		 4mwzB-5jjcA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jm7 AEROBACTIN SYNTHASE
IUCA

(Klebsiella
pneumoniae) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		4 GLY A 440
ILE A 429
LEU A 411
LEU A 408
 None
 0.81A 4mwzB-5jm7A:
undetectable		 4mwzB-5jm7A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jmv PROBABLE
BIFUNCTIONAL TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN

(Methanocaldococcus
jannaschii) 		PF00814
(Peptidase_M22) 		4 GLY A 293
GLY A   5
ILE A  71
LEU A   6
 None
 0.78A 4mwzB-5jmvA:
undetectable		 4mwzB-5jmvA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k7b BECLIN-2

(Homo sapiens) 		PF04111
(APG6) 		4 GLU A 165
LEU A 166
LEU A 169
GLU A 170
 None
 0.34A 4mwzB-5k7bA:
undetectable		 4mwzB-5k7bA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k95 GTP CYCLOHYDROLASE
FOLE2

(Neisseria
gonorrhoeae) 		PF02649
(GCHY-1) 		4 GLY A  95
GLY A 126
LEU A  79
LEU A  82
 None
 0.68A 4mwzB-5k95A:
undetectable		 4mwzB-5k95A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kei 2,3-DIHYDROXYBENZOAT
E-AMP LIGASE

(Mycolicibacterium
smegmatis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 GLY A 463
ILE A 499
LEU A 490
GLU A 497
 None
 0.80A 4mwzB-5keiA:
undetectable		 4mwzB-5keiA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kuf GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		4 GLY A  77
LEU A  54
GLU A  12
LYS A  51
 None
 0.82A 4mwzB-5kufA:
undetectable		 4mwzB-5kufA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l5n PLEXIN-A4

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG) 		4 GLY A 804
GLU A 808
LEU A 812
LYS A 815
 GLY  A 804 ( 0.0A)
GLU  A 808 ( 0.5A)
LEU  A 812 ( 0.5A)
LYS  A 815 ( 0.0A)
 0.78A 4mwzB-5l5nA:
undetectable		 4mwzB-5l5nA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l7d SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG

(Escherichia
coli;
Homo sapiens) 		PF01392
(Fz)
PF01534
(Frizzled)
PF07361
(Cytochrom_B562) 		4 GLY A 299
GLY A 214
ILE A 215
LEU A 197
 None
 0.83A 4mwzB-5l7dA:
undetectable		 4mwzB-5l7dA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lj6 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Aggregatibacter
actinomycetemcomitans) 		no annotation 4 GLY A 161
GLY A  88
ILE A 164
LEU A  82
 None
 0.80A 4mwzB-5lj6A:
undetectable		 4mwzB-5lj6A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)

(Helicobacter
pylori) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		4 GLY A 187
GLY A 190
ILE A 191
LEU A 400
 None
 0.66A 4mwzB-5lp4A:
undetectable		 4mwzB-5lp4A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfr MALATE DEHYDROGENASE

(Plasmodium
falciparum) 		no annotation 4 GLY A  78
GLY A  10
ILE A  12
LEU A   6
 None
 0.78A 4mwzB-5nfrA:
undetectable		 4mwzB-5nfrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ol2 ELECTRON TRANSFER
FLAVOPROTEIN LARGE
SUBUNIT

(Clostridioides
difficile) 		no annotation 4 GLY A  96
ILE A   8
LEU A  23
LEU A  20
 None
 0.81A 4mwzB-5ol2A:
undetectable		 4mwzB-5ol2A:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb ORIGIN RECOGNITION
COMPLEX SUBUNIT 4

(Saccharomyces
cerevisiae) 		PF14629
(ORC4_C) 		4 GLY D 102
GLU D 115
LEU D 111
LEU D 112
 None
 0.85A 4mwzB-5udbD:
undetectable		 4mwzB-5udbD:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ume 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE

(Haemophilus
influenzae) 		PF02219
(MTHFR) 		4 GLY A 266
ILE A 261
GLU A   6
LEU A  10
 None
 0.85A 4mwzB-5umeA:
undetectable		 4mwzB-5umeA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		4 GLY B 144
GLY B 104
GLU B 111
LEU B 112
 GDP  B 501 (-4.6A)
None
None
None
 0.69A 4mwzB-5w3jB:
undetectable		 4mwzB-5w3jB:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi 40S RIBOSOMAL
PROTEIN S7, PUTATIVE

(Trichomonas
vaginalis) 		PF01251
(Ribosomal_S7e) 		4 ILE H  71
LEU H  58
LEU H  61
GLU H  62
 None
 0.83A 4mwzB-5xyiH:
undetectable		 4mwzB-5xyiH:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y0m -

(-) 		no annotation 4 GLY A 111
GLY A 108
ILE A 145
LEU A 106
 GOL  A1003 (-4.2A)
None
None
None
 0.79A 4mwzB-5y0mA:
undetectable		 4mwzB-5y0mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fu4 PROBABLE CHEMOTAXIS
TRANSDUCER

(Pseudomonas
aeruginosa) 		no annotation 4 GLY A 148
GLY A 153
GLU A 139
LEU A 140
 None
 0.76A 4mwzB-6fu4A:
undetectable		 4mwzB-6fu4A:
undetectable