SIMILAR PATTERNS OF AMINO ACIDS FOR 4MV7_A_PPFA501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)

(Pyrococcus
furiosus) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		4 ASN A 329
VAL A 294
GLU A 304
ARG A 282
 None
None
PTT  A 800 (-3.5A)
None
 1.27A 4mv7A-1b25A:
undetectable		 4mv7A-1b25A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gtk PORPHOBILINOGEN
DEAMINASE

(Escherichia
coli) 		PF01379
(Porphobil_deam)
PF03900
(Porphobil_deamC) 		4 ASN A 235
VAL A 228
GLU A 231
ARG A 101
 None
 1.22A 4mv7A-1gtkA:
3.1		 4mv7A-1gtkA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gxn PECTATE LYASE

(Cellvibrio
japonicus) 		PF09492
(Pec_lyase) 		4 ASN A 603
ARG A 567
GLN A 502
VAL A 505
 None
 1.01A 4mv7A-1gxnA:
undetectable		 4mv7A-1gxnA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hc7 PROLYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		4 ARG A 264
GLN A 225
GLU A 215
ARG A 445
 None
 1.37A 4mv7A-1hc7A:
3.2		 4mv7A-1hc7A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hzf COMPLEMENT FACTOR
C4A

(Homo sapiens) 		PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		4 ASN A1116
VAL A1114
GLU A1118
ARG A1107
 None
 1.10A 4mv7A-1hzfA:
undetectable		 4mv7A-1hzfA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iho PANTOATE--BETA-ALANI
NE LIGASE

(Escherichia
coli) 		PF02569
(Pantoate_ligase) 		4 ARG A 160
VAL A 173
GLU A 171
ARG A  47
 None
 1.36A 4mv7A-1ihoA:
4.3		 4mv7A-1ihoA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kaw SINGLE-STRANDED DNA
BINDING PROTEIN

(Escherichia
coli) 		PF00436
(SSB) 		4 ASN A  31
VAL A 102
GLU A 100
ARG A  84
 None
 1.09A 4mv7A-1kawA:
undetectable		 4mv7A-1kawA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pfx FACTOR IXA

(Sus scrofa) 		PF00089
(Trypsin) 		4 ASN C  21
GLN C 156
VAL C 144
ARG C 150
 None
 1.33A 4mv7A-1pfxC:
undetectable		 4mv7A-1pfxC:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rc9 CYSTEINE-RICH
SECRETORY PROTEIN

(Trimeresurus
stejnegeri) 		PF00188
(CAP)
PF08562
(Crisp) 		4 ASN A  48
GLN A 146
VAL A 144
GLU A  75
 None
 0.82A 4mv7A-1rc9A:
undetectable		 4mv7A-1rc9A:
16.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ulz PYRUVATE CARBOXYLASE
N-TERMINAL DOMAIN

(Aquifex
aeolicus) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		7 LYS A 236
ASN A 289
ARG A 291
GLN A 293
VAL A 294
GLU A 295
ARG A 337
 None
 0.30A 4mv7A-1ulzA:
57.4		 4mv7A-1ulzA:
50.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vq0 33 KDA CHAPERONIN

(Thermotoga
maritima) 		PF01430
(HSP33) 		4 ASN A  97
VAL A 104
GLU A 135
ARG A  42
 None
 0.80A 4mv7A-1vq0A:
undetectable		 4mv7A-1vq0A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vzy 33 KDA CHAPERONIN

(Bacillus
subtilis) 		PF01430
(HSP33) 		4 ASN A  99
VAL A 106
GLU A 138
ARG A  44
 None
 0.93A 4mv7A-1vzyA:
undetectable		 4mv7A-1vzyA:
23.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1w93 ACETYL-COENZYME A
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 LYS A 327
ASN A 381
ARG A 383
GLN A 385
 None
 1.10A 4mv7A-1w93A:
36.6		 4mv7A-1w93A:
34.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wvr TRIFLIN

(Protobothrops
flavoviridis) 		PF00188
(CAP)
PF08562
(Crisp) 		4 ASN A  48
GLN A 146
VAL A 144
GLU A  75
 None
 0.81A 4mv7A-1wvrA:
undetectable		 4mv7A-1wvrA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xx5 NATRIN 1

(Naja atra) 		PF00188
(CAP)
PF08562
(Crisp) 		4 ASN A  48
GLN A 146
VAL A 144
GLU A  75
 None
 0.81A 4mv7A-1xx5A:
undetectable		 4mv7A-1xx5A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c9k PESTICIDAL CRYSTAL
PROTEIN CRY4AA

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 ASN A 312
GLN A 540
GLU A 673
ARG A 589
 None
 1.36A 4mv7A-2c9kA:
undetectable		 4mv7A-2c9kA:
21.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dzd PYRUVATE CARBOXYLASE

(Geobacillus
thermodenitrificans) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		6 LYS A 242
ASN A 294
ARG A 296
GLN A 298
VAL A 299
GLU A 300
 None
 0.76A 4mv7A-2dzdA:
54.0		 4mv7A-2dzdA:
45.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR

(Escherichia
coli) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02559
(CarD_CdnL_TRCF)
PF03461
(TRCF) 		4 ASN A1081
VAL A1086
GLU A1079
ARG A1118
 None
 1.22A 4mv7A-2eyqA:
2.3		 4mv7A-2eyqA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08990
(Docking)
PF16197
(KAsynt_C_assoc) 		4 ARG A 486
VAL A 889
GLU A 126
ARG A 130
 None
 0.97A 4mv7A-2hg4A:
4.3		 4mv7A-2hg4A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qf7 PYRUVATE CARBOXYLASE
PROTEIN

(Rhizobium etli) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		6 LYS A 245
ASN A 299
ARG A 301
GLN A 303
VAL A 304
GLU A 305
 AGS  A1162 (-3.5A)
AGS  A1162 ( 3.7A)
None
None
None
None
 0.84A 4mv7A-2qf7A:
54.8		 4mv7A-2qf7A:
21.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vpq ACETYL-COA
CARBOXYLASE

(Staphylococcus
aureus) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		7 LYS A 236
ASN A 290
ARG A 292
GLN A 294
VAL A 295
GLU A 296
ARG A 338
 None
MG  A1450 ( 4.0A)
CL  A1452 (-3.0A)
None
CL  A1452 (-4.1A)
CL  A1452 ( 4.7A)
None
 0.61A 4mv7A-2vpqA:
57.6		 4mv7A-2vpqA:
52.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vqd BIOTIN CARBOXYLASE

(Pseudomonas
aeruginosa) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		7 LYS A 238
ASN A 290
ARG A 292
GLN A 294
VAL A 295
GLU A 296
ARG A 338
 None
MG  A1449 ( 4.3A)
None
None
None
None
None
 0.59A 4mv7A-2vqdA:
62.1		 4mv7A-2vqdA:
68.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xoc E3 UBIQUITIN-PROTEIN
LIGASE CHFR

(Homo sapiens) 		no annotation 4 ARG A 504
VAL A 505
GLU A 498
ARG A 495
 None
 1.32A 4mv7A-2xocA:
undetectable		 4mv7A-2xocA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xt6 2-OXOGLUTARATE
DECARBOXYLASE

(Mycolicibacterium
smegmatis) 		PF00198
(2-oxoacid_dh)
PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		4 LYS A1118
ARG A1200
GLN A1218
GLU A1122
 None
 1.20A 4mv7A-2xt6A:
2.6		 4mv7A-2xt6A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xuz IRON-UPTAKE
SYSTEM-BINDING
PROTEIN

(Bacillus
subtilis) 		PF01497
(Peripla_BP_2) 		4 LYS A 105
ARG A 178
GLN A 277
GLU A  45
 EB4  A1300 ( 2.9A)
EB4  A1300 (-4.1A)
None
None
 1.26A 4mv7A-2xuzA:
5.5		 4mv7A-2xuzA:
21.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2yl2 ACETYL-COA
CARBOXYLASE 1

(Homo sapiens) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ASN A 476
ARG A 478
GLN A 480
VAL A 481
 None
 0.99A 4mv7A-2yl2A:
39.5		 4mv7A-2yl2A:
32.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2yl2 ACETYL-COA
CARBOXYLASE 1

(Homo sapiens) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ASN A 476
ARG A 478
VAL A 481
GLU A 482
 None
 0.94A 4mv7A-2yl2A:
39.5		 4mv7A-2yl2A:
32.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2yl2 ACETYL-COA
CARBOXYLASE 1

(Homo sapiens) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 LYS A 423
ASN A 476
ARG A 478
GLN A 480
 None
 0.95A 4mv7A-2yl2A:
39.5		 4mv7A-2yl2A:
32.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aeh HEMOGLOBIN-BINDING
PROTEASE HBP
AUTOTRANSPORTER

(Escherichia
coli) 		PF03797
(Autotransporter) 		4 ARG A1282
GLN A1247
GLU A1245
ARG A1301
 None
 1.29A 4mv7A-3aehA:
undetectable		 4mv7A-3aehA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b89 16S RRNA METHYLASE

(Escherichia
coli) 		PF07091
(FmrO) 		4 GLN A  40
VAL A  42
GLU A  43
ARG A  46
 None
 1.23A 4mv7A-3b89A:
4.4		 4mv7A-3b89A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bzm MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE

(Escherichia
coli) 		PF00425
(Chorismate_bind) 		4 ASN A  59
GLN A  57
GLU A 381
ARG A 246
 CIT  A 432 (-2.9A)
CIT  A 432 (-2.6A)
None
None
 0.78A 4mv7A-3bzmA:
undetectable		 4mv7A-3bzmA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cia COLD-ACTIVE
AMINOPEPTIDASE

(Colwellia
psychrerythraea) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		4 LYS A 586
ASN A 320
GLU A 554
ARG A 584
 None
 1.28A 4mv7A-3ciaA:
undetectable		 4mv7A-3ciaA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1l PUTATIVE NADP
OXIDOREDUCTASE
BF3122

(Bacteroides
fragilis) 		PF03807
(F420_oxidored)
PF10728
(DUF2520) 		4 ASN A 105
VAL A 116
GLU A 139
ARG A 168
 None
 0.97A 4mv7A-3d1lA:
6.6		 4mv7A-3d1lA:
21.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g8d BIOTIN CARBOXYLASE

(Escherichia
coli) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		6 LYS A 238
ASN A 290
ARG A 292
GLN A 294
VAL A 295
ARG A 338
 SO4  A1003 (-3.4A)
SO4  A1003 (-4.1A)
SO4  A1003 (-2.9A)
SO4  A1003 (-3.4A)
SO4  A1003 (-3.8A)
SO4  A1003 (-3.5A)
 0.28A 4mv7A-3g8dA:
63.9		 4mv7A-3g8dA:
82.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ho8 PYRUVATE CARBOXYLASE

(Staphylococcus
aureus) 		PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 LYS A 273
ASN A 326
ARG A 328
VAL A 331
GLU A 332
 None
 0.92A 4mv7A-3ho8A:
54.2		 4mv7A-3ho8A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ho8 PYRUVATE CARBOXYLASE

(Staphylococcus
aureus) 		PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 LYS A 273
ASN A 326
GLN A 330
VAL A 331
GLU A 332
 None
 1.06A 4mv7A-3ho8A:
54.2		 4mv7A-3ho8A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ho8 PYRUVATE CARBOXYLASE

(Staphylococcus
aureus) 		PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 LYS A 273
GLN A 330
VAL A 331
GLU A 332
ARG A 377
 None
 1.19A 4mv7A-3ho8A:
54.2		 4mv7A-3ho8A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT

(Saccharomyces
cerevisiae) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 ASN A 284
VAL A 286
GLU A 292
ARG A 138
 None
 1.30A 4mv7A-3iayA:
undetectable		 4mv7A-3iayA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mbe MHC CLASS II H2-IAG7
BETA CHAIN

(Mus musculus) 		PF00969
(MHC_II_beta)
PF07654
(C1-set) 		4 ARG B  25
VAL B  27
GLU B  14
ARG B  29
 None
 1.29A 4mv7A-3mbeB:
undetectable		 4mv7A-3mbeB:
18.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n6r PROPIONYL-COA
CARBOXYLASE, ALPHA
SUBUNIT

(Ruegeria
pomeroyi) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		7 LYS A 298
ASN A 351
ARG A 353
GLN A 355
VAL A 356
GLU A 357
ARG A 399
 None
 0.63A 4mv7A-3n6rA:
56.6		 4mv7A-3n6rA:
32.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nv3 GALECTIN 9 SHORT
ISOFORM VARIANT

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		4 ARG A 221
VAL A 246
GLU A 258
ARG A 260
 None
None
NAG  A 502 ( 2.7A)
NAG  A 502 (-4.0A)
 1.31A 4mv7A-3nv3A:
undetectable		 4mv7A-3nv3A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o7j OHCU DECARBOXYLASE

(Klebsiella
pneumoniae) 		PF09349
(OHCU_decarbox) 		4 ARG A 124
GLN A 151
GLU A 147
ARG A 135
 None
 1.10A 4mv7A-3o7jA:
undetectable		 4mv7A-3o7jA:
19.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ouu BIOTIN CARBOXYLASE

(Campylobacter
jejuni) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		7 LYS A 238
ASN A 291
ARG A 293
GLN A 295
VAL A 296
GLU A 297
ARG A 338
 CA  A 459 ( 4.7A)
CA  A 458 (-4.3A)
None
None
None
None
None
 0.65A 4mv7A-3ouuA:
53.0		 4mv7A-3ouuA:
49.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Escherichia
coli) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		4 ARG A 334
GLN A 402
GLU A 375
ARG A 107
 None
 1.21A 4mv7A-3ps9A:
3.4		 4mv7A-3ps9A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qcw NEUREXIN-1-ALPHA

(Bos taurus) 		PF00008
(EGF)
PF02210
(Laminin_G_2) 		4 ASN A 521
VAL A 648
GLU A 519
ARG A 704
 None
 1.22A 4mv7A-3qcwA:
undetectable		 4mv7A-3qcwA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slt SERINE PROTEASE ESPP

(Escherichia
coli) 		PF03797
(Autotransporter) 		4 ARG A1205
GLN A1170
GLU A1168
ARG A1224
 None
 1.32A 4mv7A-3sltA:
undetectable		 4mv7A-3sltA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3syb GLYCINE-GLUTAMATE
DIPEPTIDE PORIN OPDP

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		4 ASN A 172
ARG A 205
GLU A 216
ARG A 220
 None
 0.95A 4mv7A-3sybA:
undetectable		 4mv7A-3sybA:
23.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3u9s METHYLCROTONYL-COA
CARBOXYLASE,
ALPHA-SUBUNIT

(Pseudomonas
aeruginosa) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		6 LYS A 284
ASN A 337
ARG A 339
GLN A 341
GLU A 343
ARG A 385
 None
 0.74A 4mv7A-3u9sA:
56.2		 4mv7A-3u9sA:
37.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3u9s METHYLCROTONYL-COA
CARBOXYLASE,
ALPHA-SUBUNIT

(Pseudomonas
aeruginosa) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		6 LYS A 284
ASN A 337
ARG A 339
VAL A 342
GLU A 343
ARG A 385
 None
 0.42A 4mv7A-3u9sA:
56.2		 4mv7A-3u9sA:
37.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9w LEUKOTRIENE A-4
HYDROLASE

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		4 LYS A1565
ASN A1291
GLU A1533
ARG A1563
 None
 1.37A 4mv7A-3u9wA:
undetectable		 4mv7A-3u9wA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va7 KLLA0E08119P

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		7 LYS A 858
ASN A 912
ARG A 914
GLN A 916
VAL A 917
GLU A 918
ARG A 960
 GOL  A1904 (-3.0A)
GOL  A1904 ( 4.3A)
GOL  A1904 ( 3.0A)
GOL  A1904 (-4.5A)
GOL  A1904 (-3.9A)
GOL  A1904 (-2.8A)
GOL  A1904 (-4.0A)
 0.65A 4mv7A-3va7A:
55.7		 4mv7A-3va7A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vv1 PROTEIN LEC-6

(Caenorhabditis
elegans) 		PF00337
(Gal-bind_lectin) 		4 ARG A  46
VAL A  71
GLU A  83
ARG A  85
 FUC  A 202 ( 4.7A)
None
FUC  A 202 (-2.7A)
FUC  A 202 ( 4.1A)
 1.26A 4mv7A-3vv1A:
undetectable		 4mv7A-3vv1A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wmx NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E

(Cupriavidus
necator) 		PF01370
(Epimerase) 		4 ASN A 242
GLN A 134
GLU A 237
ARG A 156
 None
 1.33A 4mv7A-3wmxA:
4.5		 4mv7A-3wmxA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wv6 GALECTIN-9

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		4 ARG A  44
VAL A  73
GLU A  85
ARG A  87
 GAL  A 402 ( 4.9A)
None
BGC  A 403 (-2.9A)
BGC  A 403 (-4.1A)
 1.32A 4mv7A-3wv6A:
undetectable		 4mv7A-3wv6A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxm PROTEIN PELOTA
HOMOLOG

(Aeropyrum
pernix) 		PF03463
(eRF1_1)
PF03465
(eRF1_3) 		4 ARG B  61
VAL B  35
GLU B 107
ARG B  59
 None
 1.22A 4mv7A-3wxmB:
2.9		 4mv7A-3wxmB:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhr MULTIFUNCTIONAL
2-OXOGLUTARATE
METABOLISM ENZYME

(Mycolicibacterium
smegmatis) 		PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		4 LYS A1118
ARG A1200
GLN A1218
GLU A1122
 None
 1.23A 4mv7A-3zhrA:
undetectable		 4mv7A-3zhrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zxe GALECTIN-7

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		4 ARG A  31
VAL A  60
GLU A  72
ARG A  74
 PGZ  A   1 ( 4.7A)
None
PGZ  A   1 (-3.5A)
None
 1.26A 4mv7A-3zxeA:
undetectable		 4mv7A-3zxeA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyi LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4

(Homo sapiens) 		PF07679
(I-set)
PF13855
(LRR_8) 		4 ASN A  81
GLN A 105
VAL A 103
GLU A 129
 None
 1.18A 4mv7A-3zyiA:
undetectable		 4mv7A-3zyiA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d72 GLYCOSIDE HYDROLASE

(Streptococcus
pneumoniae) 		PF08306
(Glyco_hydro_98M)
PF08307
(Glyco_hydro_98C) 		4 ASN A 856
VAL A 859
GLU A 861
ARG A 776
 None
 1.18A 4mv7A-4d72A:
undetectable		 4mv7A-4d72A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eb5 PROBABLE CYSTEINE
DESULFURASE 2

(Archaeoglobus
fulgidus) 		PF00266
(Aminotran_5) 		4 ASN A 148
GLN A 145
VAL A 144
GLU A  97
 None
 1.29A 4mv7A-4eb5A:
2.5		 4mv7A-4eb5A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3a CLIP-ASSOCIATING
PROTEIN

(Drosophila
melanogaster) 		PF12348
(CLASP_N) 		4 ASN A 154
ARG A 115
GLN A 111
GLU A 147
 None
 1.32A 4mv7A-4g3aA:
undetectable		 4mv7A-4g3aA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h3s GLUTAMINE-TRNA
LIGASE

(Saccharomyces
cerevisiae) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C)
PF04557
(tRNA_synt_1c_R2) 		4 ASN A 707
VAL A 801
GLU A 556
ARG A 560
 None
 1.32A 4mv7A-4h3sA:
3.7		 4mv7A-4h3sA:
19.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hq6 ACETYL-COA
CARBOXYLASE 2

(Homo sapiens) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 LYS A 529
ASN A 582
ARG A 584
GLN A 586
VAL A 587
 None
 0.95A 4mv7A-4hq6A:
37.9		 4mv7A-4hq6A:
32.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hq6 ACETYL-COA
CARBOXYLASE 2

(Homo sapiens) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 LYS A 529
ASN A 582
ARG A 584
VAL A 587
GLU A 588
 None
 1.18A 4mv7A-4hq6A:
37.9		 4mv7A-4hq6A:
32.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kq7 HYPOTHETICAL PROTEIN

(Bacteroides
uniformis) 		PF11175
(DUF2961) 		4 ARG A 385
GLN A 185
GLU A 183
ARG A 122
 None
 1.06A 4mv7A-4kq7A:
undetectable		 4mv7A-4kq7A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lwo ARGININE
N-METHYLTRANSFERASE,
PUTATIVE

(Trypanosoma
brucei) 		no annotation 4 ASN B 162
ARG B 161
GLN B 256
VAL B 255
 None
 1.06A 4mv7A-4lwoB:
3.4		 4mv7A-4lwoB:
23.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mv3 BIOTIN CARBOXYLASE

(Haemophilus
influenzae) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		6 LYS A 238
ASN A 290
ARG A 292
VAL A 295
GLU A 296
ARG A 338
 BCT  A 503 ( 3.8A)
ACP  A 501 (-3.9A)
BCT  A 503 (-2.7A)
BCT  A 503 (-3.8A)
BCT  A 503 (-3.4A)
BCT  A 503 (-3.5A)
 0.35A 4mv7A-4mv3A:
65.5		 4mv7A-4mv3A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mv3 BIOTIN CARBOXYLASE

(Haemophilus
influenzae) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		6 LYS A 238
ASN A 290
GLN A 294
VAL A 295
GLU A 296
ARG A 338
 BCT  A 503 ( 3.8A)
ACP  A 501 (-3.9A)
BCT  A 503 (-4.3A)
BCT  A 503 (-3.8A)
BCT  A 503 (-3.4A)
BCT  A 503 (-3.5A)
 0.69A 4mv7A-4mv3A:
65.5		 4mv7A-4mv3A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mz9 SINGLE-STRANDED
DNA-BINDING PROTEIN

(Escherichia
coli) 		PF00436
(SSB) 		4 ASN A  31
VAL A 102
GLU A 100
ARG A  84
 None
 0.94A 4mv7A-4mz9A:
undetectable		 4mv7A-4mz9A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ncn EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN

(Chaetomium
thermophilum) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2) 		4 GLN A 549
VAL A 548
GLU A 552
ARG A 806
 GTP  A1001 (-3.8A)
None
MG  A1002 ( 4.0A)
None
 1.23A 4mv7A-4ncnA:
undetectable		 4mv7A-4ncnA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qsl PYRUVATE CARBOXYLASE

(Listeria
monocytogenes) 		no annotation 5 ASN H 292
ARG H 294
GLN H 296
VAL H 297
GLU H 298
 None
 0.69A 4mv7A-4qslH:
54.9		 4mv7A-4qslH:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE

(Mycobacterium
avium) 		PF00289
(Biotin_carb_N)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		6 LYS A 238
ASN A 290
ARG A 292
VAL A 295
GLU A 296
ARG A 352
 None
 0.67A 4mv7A-4rcnA:
52.9		 4mv7A-4rcnA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE

(Mycobacterium
avium) 		PF00289
(Biotin_carb_N)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		6 LYS A 238
ASN A 290
GLN A 294
VAL A 295
GLU A 296
ARG A 352
 None
 0.78A 4mv7A-4rcnA:
52.9		 4mv7A-4rcnA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rmf ASPARTATE--TRNA(ASP/
ASN) LIGASE

(Mycolicibacterium
smegmatis) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		4 GLN A  47
VAL A  49
GLU A  92
ARG A  51
 None
 1.03A 4mv7A-4rmfA:
undetectable		 4mv7A-4rmfA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 ASN A 249
GLN A 473
GLU A 604
ARG A 530
 None
 1.27A 4mv7A-4w8jA:
undetectable		 4mv7A-4w8jA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj3 ASPARTATE--TRNA(ASP/
ASN) LIGASE

(Pseudomonas
aeruginosa) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		4 GLN M  47
VAL M  49
GLU M  94
ARG M  77
 U  Q  35 ( 3.4A)
None
G  Q  34 ( 2.7A)
G  Q  34 ( 3.6A)
 1.27A 4mv7A-4wj3M:
undetectable		 4mv7A-4wj3M:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsb POLYMERASE PB2

(Influenza A
virus) 		PF00604
(Flu_PB2) 		4 LYS C 134
ASN C 530
VAL C 539
GLU C 538
 None
 1.23A 4mv7A-4wsbC:
undetectable		 4mv7A-4wsbC:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y26 GALECTIN-7

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		4 ARG A  31
VAL A  60
GLU A  72
ARG A  74
 None
None
6S2  A 202 (-2.8A)
6S2  A 202 (-3.5A)
 1.20A 4mv7A-4y26A:
undetectable		 4mv7A-4y26A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxc HYDROQUINONE
DIOXYGENASE LARGE
SUBUNIT

(Pseudomonas sp.
WBC-3) 		no annotation 4 ASN W 191
ARG W 310
VAL W 228
ARG W 167
 None
 1.36A 4mv7A-4zxcW:
undetectable		 4mv7A-4zxcW:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csl ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
PF08326
(ACC_central) 		7 LYS A 327
ASN A 381
ARG A 383
GLN A 385
VAL A 386
GLU A 387
ARG A 458
 None
 0.70A 4mv7A-5cslA:
43.7		 4mv7A-5cslA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cz3 M64R

(Myxoma virus) 		PF03287
(Pox_C7_F8A) 		4 ASN A  24
VAL A  50
GLU A  52
ARG A 148
 None
 0.89A 4mv7A-5cz3A:
undetectable		 4mv7A-5cz3A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4v NUCLEOPROTEIN,PHOSPH
OPROTEIN

(Measles
morbillivirus) 		PF00973
(Paramyxo_ncap)
PF13825
(Paramyxo_PNT) 		4 LYS A 386
GLN A 347
VAL A 322
GLU A 323
 None
 1.35A 4mv7A-5e4vA:
undetectable		 4mv7A-5e4vA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey9 LONG-CHAIN-FATTY-ACI
D--AMP LIGASE FADD32

(Mycobacterium
marinum) 		PF00501
(AMP-binding) 		4 ASN A 523
VAL A 520
GLU A 546
ARG A 607
 None
 1.06A 4mv7A-5ey9A:
4.0		 4mv7A-5ey9A:
19.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h80 CARBOXYLASE

(Deinococcus
radiodurans) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		7 LYS A 235
ASN A 288
ARG A 290
GLN A 292
VAL A 293
GLU A 294
ARG A 342
 None
 0.66A 4mv7A-5h80A:
50.9		 4mv7A-5h80A:
40.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i77 ENDO-BETA-1,
4-GLUCANASE

(Aspergillus
niger) 		PF00150
(Cellulase) 		4 ASN A  38
ARG A  76
GLN A  78
GLU A  43
 None
 1.30A 4mv7A-5i77A:
undetectable		 4mv7A-5i77A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		7 LYS A 858
ASN A 912
ARG A 914
GLN A 916
VAL A 917
GLU A 918
ARG A 960
 None
 0.63A 4mv7A-5i8iA:
55.7		 4mv7A-5i8iA:
13.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ks8 PYRUVATE CARBOXYLASE
SUBUNIT ALPHA

(Methylobacillus
flagellatus) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		6 LYS A 236
ASN A 289
ARG A 291
GLN A 293
GLU A 295
ARG A 337
 None
 0.79A 4mv7A-5ks8A:
57.2		 4mv7A-5ks8A:
41.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ks8 PYRUVATE CARBOXYLASE
SUBUNIT ALPHA

(Methylobacillus
flagellatus) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		6 LYS A 236
ASN A 289
GLN A 293
VAL A 294
GLU A 295
ARG A 337
 None
 0.75A 4mv7A-5ks8A:
57.2		 4mv7A-5ks8A:
41.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mlk ACETYL-COA
CARBOXYLASE

(Mycobacterium
tuberculosis) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		7 LYS A 247
ASN A 300
ARG A 302
GLN A 304
VAL A 305
GLU A 306
ARG A 347
 None
 0.72A 4mv7A-5mlkA:
56.0		 4mv7A-5mlkA:
36.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nst HEAVY CHAIN OF
ANTIBODY MGD21

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF13895
(Ig_2) 		4 ASN B  32
VAL B 132
GLU B 167
ARG B 169
 None
None
None
GOL  B 402 (-2.9A)
 1.28A 4mv7A-5nstB:
undetectable		 4mv7A-5nstB:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udm PHAGE-ASSOCIATED
CELL WALL HYDROLASE

(Streptococcus
pyogenes) 		no annotation 4 ASN B 110
VAL B 135
GLU B 108
ARG B 137
 None
 1.34A 4mv7A-5udmB:
undetectable		 4mv7A-5udmB:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uve SUBSTRATE-BINDING
REGION OF ABC-TYPE
GLYCINE BETAINE
TRANSPORT SYSTEM

(Brucella
abortus) 		PF04069
(OpuAC) 		4 ASN A  24
VAL A 252
GLU A 251
ARG A 249
 None
 0.94A 4mv7A-5uveA:
2.2		 4mv7A-5uveA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vn4 ADENINE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE

(Trypanosoma
brucei) 		PF00156
(Pribosyltran) 		4 ASN A   9
VAL A 201
GLU A 171
ARG A  65
 None
 1.03A 4mv7A-5vn4A:
undetectable		 4mv7A-5vn4A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vtm TYPE II SECRETION
SYSTEM PROTEIN J

(Pseudomonas
aeruginosa) 		no annotation 4 GLN W 140
VAL W 138
GLU W 121
ARG W 123
 None
 1.01A 4mv7A-5vtmW:
undetectable		 4mv7A-5vtmW:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyw PYRUVATE CARBOXYLASE

(Lactococcus
lactis) 		PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		7 LYS A 236
ASN A 288
ARG A 290
GLN A 292
VAL A 293
GLU A 294
ARG A 341
 None
 0.80A 4mv7A-5vywA:
54.8		 4mv7A-5vywA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x09 V-TYPE ATP SYNTHASE
ALPHA CHAIN,V-TYPE
ATP SYNTHASE ALPHA
CHAIN

(Pyrococcus
horikoshii) 		no annotation 4 ASN A 450
VAL A 209
GLU A 208
ARG A 373
 None
 1.26A 4mv7A-5x09A:
3.5		 4mv7A-5x09A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c66 CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY

(Thermobifida
fusca) 		no annotation 4 ARG A 203
VAL A 202
GLU A 141
ARG A 200
 None
 1.31A 4mv7A-6c66A:
undetectable		 4mv7A-6c66A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE

(Bacteroides
thetaiotaomicron) 		no annotation 4 LYS A 375
ASN A 342
VAL A 339
ARG A 379
 None
 1.01A 4mv7A-6f8zA:
undetectable		 4mv7A-6f8zA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhs INO80

(Chaetomium
thermophilum) 		no annotation 4 ARG G1308
VAL G1477
GLU G1312
ARG G1314
 None
 1.22A 4mv7A-6fhsG:
undetectable		 4mv7A-6fhsG:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fml INO80

(Chaetomium
thermophilum) 		no annotation 4 ARG G1308
VAL G1477
GLU G1312
ARG G1314
 None
 1.23A 4mv7A-6fmlG:
2.3		 4mv7A-6fmlG:
10.48