SIMILAR PATTERNS OF AMINO ACIDS FOR 4MUB_A_OAQA302_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c30 | CARBAMOYL PHOSPHATESYNTHETASE: LARGESUBUNIT (Escherichiacoli) |
PF02142(MGS)PF02786(CPSase_L_D2)PF02787(CPSase_L_D3) | 5 | PRO A 17PHE A 26VAL A 19GLY A 245MET A 174 | NoneNoneNoneNonePO4 A4005 (-4.1A) | 1.33A | 4mubA-1c30A:undetectable | 4mubA-1c30A:12.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ciy | CRYIA(A) (Bacillusthuringiensis) |
PF00555(Endotoxin_M)PF03944(Endotoxin_C)PF03945(Endotoxin_N) | 5 | PRO A 450LEU A 383GLY A 356PHE A 388THR A 386 | None | 1.44A | 4mubA-1ciyA:undetectable | 4mubA-1ciyA:16.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cvr | GINGIPAIN R (Porphyromonasgingivalis) |
PF01364(Peptidase_C25)PF03785(Peptidase_C25_C) | 5 | PRO A 237PHE A 256VAL A 206GLY A 210THR A 219 | NoneNoneNoneH37 A 501 (-3.5A)None | 1.46A | 4mubA-1cvrA:undetectable | 4mubA-1cvrA:20.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gve | AFLATOXIN B1ALDEHYDE REDUCTASEMEMBER 3 (Rattusnorvegicus) |
PF00248(Aldo_ket_red) | 5 | PHE A 311LEU A 317GLY A 199MET A 259THR A 202 | NoneNoneNAP A1328 (-3.2A)NoneNAP A1328 ( 4.0A) | 1.14A | 4mubA-1gveA:undetectable | 4mubA-1gveA:20.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h39 | SQUALENE--HOPENECYCLASE (Alicyclobacillusacidocaldarius) |
PF13243(SQHop_cyclase_C)PF13249(SQHop_cyclase_N) | 5 | PRO A 429HIS A 431VAL A 440GLY A 603ASP A 604 | NoneNoneR03 A 800 ( 4.9A)NoneNone | 1.40A | 4mubA-1h39A:undetectable | 4mubA-1h39A:17.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ktc | ALPHA-N-ACETYLGALACTOSAMINIDASE (Gallus gallus) |
PF16499(Melibiase_2)PF17450(Melibiase_2_C) | 5 | PRO A 263MET A 237LEU A 265GLY A 141ASP A 140 | NoneNoneNoneNoneNGA A 870 (-3.0A) | 1.40A | 4mubA-1ktcA:undetectable | 4mubA-1ktcA:21.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t5j | HYPOTHETICAL PROTEINMJ1187 (Methanocaldococcusjannaschii) |
PF03747(ADP_ribosyl_GH) | 5 | PRO A 96LEU A 54GLY A 220ASP A 253THR A 60 | NoneNoneNone MG A 500 (-3.3A) MG A 500 (-3.9A) | 1.29A | 4mubA-1t5jA:undetectable | 4mubA-1t5jA:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1taq | TAQ DNA POLYMERASE (Thermusaquaticus) |
PF00476(DNA_pol_A)PF01367(5_3_exonuc)PF02739(5_3_exonuc_N)PF09281(Taq-exonuc) | 5 | HIS A 639VAL A 631GLY A 624ASP A 625PHE A 700 | None | 1.30A | 4mubA-1taqA:undetectable | 4mubA-1taqA:13.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1td2 | PYRIDOXAMINE KINASE (Escherichiacoli) |
PF08543(Phos_pyr_kin) | 5 | PRO A 176LEU A 137VAL A 179GLY A 223THR A 226 | None | 1.39A | 4mubA-1td2A:undetectable | 4mubA-1td2A:22.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1txk | GLUCANS BIOSYNTHESISPROTEIN G (Escherichiacoli) |
PF04349(MdoG) | 5 | PHE A 220LEU A 203VAL A 149GLY A 153PHE A 133 | None | 1.34A | 4mubA-1txkA:undetectable | 4mubA-1txkA:18.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vcj | NEURAMINIDASE (Influenza Bvirus) |
PF00064(Neur) | 5 | PRO A 267MET A 239VAL A 303GLY A 351THR A 274 | None | 1.35A | 4mubA-1vcjA:undetectable | 4mubA-1vcjA:20.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1woi | AGMATINASE (Deinococcusradiodurans) |
PF00491(Arginase) | 5 | MET A 294LEU A 75VAL A 31GLY A 84ASP A 82 | None | 1.44A | 4mubA-1woiA:undetectable | 4mubA-1woiA:18.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x3d | FIBRONECTIN TYPE-IIIDOMAIN CONTAININGPROTEIN 3A (Homo sapiens) |
PF00041(fn3) | 5 | PRO A 23VAL A 105GLY A 58ASP A 56PHE A 64 | None | 1.30A | 4mubA-1x3dA:undetectable | 4mubA-1x3dA:17.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2abq | FRUCTOSE 1-PHOSPHATEKINASE (Bacillushalodurans) |
PF00294(PfkB) | 5 | PRO A 136LEU A 7GLY A 248ASP A 249THR A 6 | None | 1.38A | 4mubA-2abqA:1.9 | 4mubA-2abqA:21.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c1u | DI-HAEM CYTOCHROME CPEROXIDASE (Paracoccuspantotrophus) |
PF00034(Cytochrom_C)PF03150(CCP_MauG) | 5 | LEU A 264VAL A 286GLY A 245PHE A 274THR A 244 | HEC A 402 (-4.8A)HEC A 402 ( 4.2A)NoneHEC A 402 (-4.3A)None | 1.36A | 4mubA-2c1uA:undetectable | 4mubA-2c1uA:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gp6 | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 2 (Mycobacteriumtuberculosis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | HIS A 307GLY A 318ASP A 319PHE A 230THR A 371 | None | 1.41A | 4mubA-2gp6A:undetectable | 4mubA-2gp6A:18.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h6e | D-ARABINOSE1-DEHYDROGENASE (Sulfolobussolfataricus) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | LEU A 190VAL A 176GLY A 247THR A 186THR A 251 | None | 1.39A | 4mubA-2h6eA:undetectable | 4mubA-2h6eA:22.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hdn | ELONGATION FACTOREF-TU (Escherichiacoli) |
PF00009(GTP_EFTU)PF03143(GTP_EFTU_D3)PF03144(GTP_EFTU_D2) | 5 | PHE B 322LEU B 311GLY B 339THR B 382MET B 358 | None | 1.25A | 4mubA-2hdnB:undetectable | 4mubA-2hdnB:20.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i5b | PHOSPHOMETHYLPYRIMIDINE KINASE (Bacillussubtilis) |
PF08543(Phos_pyr_kin) | 5 | LEU A 226VAL A 105GLY A 19ASP A 23PHE A 27 | None | 1.36A | 4mubA-2i5bA:2.1 | 4mubA-2i5bA:24.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jgd | 2-OXOGLUTARATEDEHYDROGENASE E1COMPONENT (Escherichiacoli) |
PF00676(E1_dh)PF02779(Transket_pyr)PF16870(OxoGdeHyase_C) | 5 | MET A 238LEU A 235VAL A 270GLY A 247THR A 307 | None | 1.43A | 4mubA-2jgdA:undetectable | 4mubA-2jgdA:14.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nzu | CATABOLITE CONTROLPROTEIN (Bacillusmegaterium) |
PF13377(Peripla_BP_3) | 5 | MET G 112LEU G 109VAL G 142MET G 309THR G 306 | None | 1.34A | 4mubA-2nzuG:undetectable | 4mubA-2nzuG:22.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2og7 | ASPARAGINE OXYGENASE (Streptomycescoelicolor) |
PF02668(TauD) | 5 | PRO A 236LEU A 229VAL A 188GLY A 288THR A 185 | None | 1.45A | 4mubA-2og7A:undetectable | 4mubA-2og7A:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ogj | DIHYDROOROTASE (Agrobacteriumfabrum) |
PF01979(Amidohydro_1) | 5 | LEU A 335VAL A 74GLY A 264ASP A 262THR A 290 | None | 1.45A | 4mubA-2ogjA:undetectable | 4mubA-2ogjA:20.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qy6 | UPF0209 PROTEIN YFCK (Escherichiacoli) |
PF05430(Methyltransf_30) | 5 | HIS A 134LEU A 140GLY A 199ASP A 198THR A 95 | None | 1.42A | 4mubA-2qy6A:undetectable | 4mubA-2qy6A:20.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w35 | ENDONUCLEASE V (Thermotogamaritima) |
PF04493(Endonuclease_5) | 5 | PRO A 47LEU A 53GLY A 111ASP A 110THR A 217 | NoneNoneNone MG A1224 (-3.2A)None | 1.44A | 4mubA-2w35A:undetectable | 4mubA-2w35A:20.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wab | ENDOGLUCANASE E (Ruminiclostridiumthermocellum) |
PF00657(Lipase_GDSL) | 5 | PHE A 236LEU A 269VAL A 260GLY A 129ASP A 130 | None | 1.46A | 4mubA-2wabA:2.1 | 4mubA-2wabA:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xfs | ORF12 (Streptomycesclavuligerus) |
PF13354(Beta-lactamase2) | 5 | PRO A 208LEU A 207GLY A 218ASP A 217THR A 219 | None | 1.42A | 4mubA-2xfsA:undetectable | 4mubA-2xfsA:19.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y24 | XYLANASE (Dickeyachrysanthemi) |
PF02055(Glyco_hydro_30)PF17189(Glyco_hydro_30C) | 5 | PRO A 115LEU A 131GLY A 228PHE A 182THR A 252 | None | 0.89A | 4mubA-2y24A:undetectable | 4mubA-2y24A:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y24 | XYLANASE (Dickeyachrysanthemi) |
PF02055(Glyco_hydro_30)PF17189(Glyco_hydro_30C) | 5 | PRO A 115LEU A 131GLY A 229PHE A 182THR A 252 | None | 1.40A | 4mubA-2y24A:undetectable | 4mubA-2y24A:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yzw | ADP-RIBOSYLGLYCOHYDROLASE (Thermusthermophilus) |
PF03747(ADP_ribosyl_GH) | 5 | HIS A 159LEU A 165GLY A 116ASP A 117MET A 80 | None | 1.27A | 4mubA-2yzwA:undetectable | 4mubA-2yzwA:18.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z8z | LIPASE (Pseudomonas sp.MIS38) |
PF00353(HemolysinCabind) | 5 | HIS A 517VAL A 557GLY A 541ASP A 543PHE A 527 | ZN A 630 (-3.2A)None CA A 626 (-4.5A) CA A 626 (-2.2A)None | 1.39A | 4mubA-2z8zA:undetectable | 4mubA-2z8zA:16.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aeh | HEMOGLOBIN-BINDINGPROTEASE HBPAUTOTRANSPORTER (Escherichiacoli) |
PF03797(Autotransporter) | 5 | PRO A1278LEU A1255GLY A1127ASP A1135THR A1365 | None | 1.43A | 4mubA-3aehA:undetectable | 4mubA-3aehA:22.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aib | GLUCOSYLTRANSFERASE-SI (Streptococcusmutans) |
PF02324(Glyco_hydro_70) | 5 | PHE A1071VAL A1085PHE A 259THR A 254THR A 298 | None | 1.22A | 4mubA-3aibA:undetectable | 4mubA-3aibA:14.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cos | ALCOHOLDEHYDROGENASE 4 (Homo sapiens) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | HIS A 69PHE A 147VAL A 300PHE A 58THR A 52 | ZN A 501 ( 3.3A)ACY A 401 (-4.3A)NAD A 400 ( 4.2A)NoneNone | 1.43A | 4mubA-3cosA:undetectable | 4mubA-3cosA:21.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cq5 | HISTIDINOL-PHOSPHATEAMINOTRANSFERASE (Corynebacteriumglutamicum) |
PF00155(Aminotran_1_2) | 5 | LEU A 32VAL A 291GLY A 299PHE A 312THR A 343 | None | 1.31A | 4mubA-3cq5A:undetectable | 4mubA-3cq5A:20.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fz0 | NUCLEOSIDEHYDROLASE, PUTATIVE (Trypanosomabrucei) |
PF01156(IU_nuc_hydro) | 5 | PHE A 178LEU A 134VAL A 37GLY A 14ASP A 16 | BTB A 401 (-3.9A)NoneNoneNone CA A 400 (-2.3A) | 1.44A | 4mubA-3fz0A:undetectable | 4mubA-3fz0A:20.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h55 | ALPHA-N-ACETYLGALACTOSAMINIDASE (Homo sapiens) |
PF16499(Melibiase_2)PF17450(Melibiase_2_C) | 5 | PRO A 279MET A 253LEU A 281GLY A 157ASP A 156 | NoneNoneNoneNoneGLA A1000 (-3.4A) | 1.42A | 4mubA-3h55A:undetectable | 4mubA-3h55A:18.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hbj | FLAVONOID3-O-GLUCOSYLTRANSFERASE (Medicagotruncatula) |
PF00201(UDPGT) | 5 | HIS A 228LEU A 153VAL A 178ASP A 189THR A 154 | None | 1.28A | 4mubA-3hbjA:1.9 | 4mubA-3hbjA:22.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i32 | HEAT RESISTANT RNADEPENDENT ATPASE (Thermusthermophilus) |
PF00271(Helicase_C) | 5 | PHE A 284LEU A 258VAL A 243GLY A 336THR A 329 | None | 1.32A | 4mubA-3i32A:undetectable | 4mubA-3i32A:20.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ib6 | UNCHARACTERIZEDPROTEIN (Listeriamonocytogenes) |
PF13419(HAD_2) | 5 | PHE A 79LEU A 109GLY A 10THR A 105THR A 12 | None | 1.42A | 4mubA-3ib6A:undetectable | 4mubA-3ib6A:20.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ix9 | DIHYDROFOLATEREDUCTASE (Streptococcuspneumoniae) |
PF00186(DHFR_1) | 5 | LEU A 39GLY A 46THR A 38MET A 53THR A 49 | NoneNDP A 193 (-3.4A)NoneMTX A 200 ( 4.4A)NDP A 193 (-3.4A) | 1.38A | 4mubA-3ix9A:undetectable | 4mubA-3ix9A:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ktn | CARBOHYDRATE KINASE,PFKB FAMILY (Enterococcusfaecalis) |
PF00294(PfkB) | 5 | HIS A 309LEU A 307GLY A 33THR A 318THR A 34 | None | 1.44A | 4mubA-3ktnA:1.1 | 4mubA-3ktnA:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mmp | ELONGATION FACTOR TU2, ELONGATION FACTORTS (Escherichiacoli) |
PF00009(GTP_EFTU)PF00889(EF_TS)PF03143(GTP_EFTU_D3)PF03144(GTP_EFTU_D2) | 5 | PHE A1322LEU A1311GLY A1339THR A1382MET A1358 | None | 1.24A | 4mubA-3mmpA:undetectable | 4mubA-3mmpA:17.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n6r | PROPIONYL-COACARBOXYLASE, ALPHASUBUNIT (Ruegeriapomeroyi) |
PF00289(Biotin_carb_N)PF00364(Biotin_lipoyl)PF02785(Biotin_carb_C)PF02786(CPSase_L_D2) | 5 | LEU A 517VAL A 525GLY A 609THR A 629MET A 590 | None | 1.45A | 4mubA-3n6rA:undetectable | 4mubA-3n6rA:16.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oyt | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE I (Yersinia pestis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | PHE A 318LEU A 311VAL A 298GLY A 262MET A 387 | None | 1.29A | 4mubA-3oytA:undetectable | 4mubA-3oytA:19.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pzs | PYRIDOXAMINE KINASE (Yersinia pestis) |
PF08543(Phos_pyr_kin) | 5 | PRO A 175LEU A 136VAL A 178GLY A 222THR A 225 | NoneNoneNoneSO4 A 288 (-3.4A)None | 1.42A | 4mubA-3pzsA:undetectable | 4mubA-3pzsA:22.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tk1 | MEMBRANEATPASE/PROTEINKINASE (Mycolicibacteriumthermoresistibile) |
PF03308(ArgK) | 5 | LEU A 181VAL A 195GLY A 56THR A 173THR A 168 | None | 1.40A | 4mubA-3tk1A:3.6 | 4mubA-3tk1A:21.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tqi | GMP SYNTHASE[GLUTAMINE-HYDROLYZING] (Coxiellaburnetii) |
PF00117(GATase)PF00958(GMP_synt_C)PF02540(NAD_synthase) | 5 | LEU A 116GLY A 190PHE A 122THR A 157THR A 187 | None | 1.40A | 4mubA-3tqiA:2.0 | 4mubA-3tqiA:19.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uqe | 6-PHOSPHOFRUCTOKINASE ISOZYME 2 (Escherichiacoli) |
PF00294(PfkB) | 5 | PRO A 141LEU A 9GLY A 253ASP A 256THR A 8 | NoneNoneATP A 401 ( 4.1A)NoneNone | 1.31A | 4mubA-3uqeA:undetectable | 4mubA-3uqeA:19.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uqe | 6-PHOSPHOFRUCTOKINASE ISOZYME 2 (Escherichiacoli) |
PF00294(PfkB) | 5 | PRO A 141LEU A 9GLY A 255ASP A 256THR A 8 | NoneNoneATP A 401 (-3.3A)NoneNone | 1.40A | 4mubA-3uqeA:undetectable | 4mubA-3uqeA:19.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v65 | LOW-DENSITYLIPOPROTEINRECEPTOR-RELATEDPROTEIN 4 (Rattusnorvegicus) |
PF00058(Ldl_recept_b)PF14670(FXa_inhibition) | 5 | PRO B 455LEU B 442GLY B 609ASP B 606THR B 689 | None | 1.35A | 4mubA-3v65B:undetectable | 4mubA-3v65B:18.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vys | HYDROGENASEEXPRESSION/FORMATIONPROTEIN HYPD (Thermococcuskodakarensis) |
PF01924(HypD) | 5 | VAL B 37GLY B 360PHE B 149THR B 180THR B 361 | None | 1.30A | 4mubA-3vysB:undetectable | 4mubA-3vysB:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c5n | PHOSPHOMETHYLPYRIMIDINE KINASE (Staphylococcusaureus) |
PF08543(Phos_pyr_kin) | 5 | LEU A 224VAL A 103GLY A 19ASP A 23PHE A 27 | NoneNonePXL A 300 (-3.6A)NoneNone | 1.42A | 4mubA-4c5nA:1.8 | 4mubA-4c5nA:23.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c9m | CYTOCHROME P450 (Novosphingobiumaromaticivorans) |
PF00067(p450) | 5 | HIS A 355PHE A 358LEU A 296VAL A 375GLY A 257 | NoneHEM A1418 ( 4.3A)NoneNoneHEM A1418 (-3.6A) | 1.33A | 4mubA-4c9mA:undetectable | 4mubA-4c9mA:21.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cpn | NEURAMINIDASE (Influenza Bvirus) |
PF00064(Neur) | 5 | PRO A 266MET A 238VAL A 302GLY A 350THR A 273 | None | 1.38A | 4mubA-4cpnA:undetectable | 4mubA-4cpnA:19.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4evq | PUTATIVE ABCTRANSPORTER SUBUNIT,SUBSTRATE-BINDINGCOMPONENT (Rhodopseudomonaspalustris) |
PF13458(Peripla_BP_6) | 5 | PRO A 224VAL A 227GLY A 156MET A 163THR A 159 | None | 1.44A | 4mubA-4evqA:undetectable | 4mubA-4evqA:23.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fmv | GLUCURONOARABINOXYLANENDO-1,4-BETA-XYLANASE ([Clostridium]papyrosolvens) |
PF02055(Glyco_hydro_30)PF17189(Glyco_hydro_30C) | 5 | LEU A 287GLY A 208PHE A 235MET A 214THR A 209 | None | 1.18A | 4mubA-4fmvA:undetectable | 4mubA-4fmvA:19.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i3g | BETA-GLUCOSIDASE (Streptomycesvenezuelae) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C)PF14310(Fn3-like) | 5 | VAL A 513GLY A 576ASP A 575THR A 443THR A 577 | None | 1.40A | 4mubA-4i3gA:2.2 | 4mubA-4i3gA:15.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kf8 | NUP188 (Thermothelomycesthermophila) |
no annotation | 5 | PRO A1665PHE A1585LEU A1608GLY A1651MET A1638 | None | 1.30A | 4mubA-4kf8A:undetectable | 4mubA-4kf8A:21.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l8k | PUTATIVE PEPTIDASE (Parabacteroidesmerdae) |
PF03572(Peptidase_S41)PF14684(Tricorn_C1) | 5 | MET A 180PHE A 146VAL A 249GLY A 265THR A 263 | MPD A 403 ( 4.2A)NoneNoneNoneNone | 1.20A | 4mubA-4l8kA:undetectable | 4mubA-4l8kA:23.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o6v | OXIDOREDUCTASE,SHORT-CHAINDEHYDROGENASE/REDUCTASE FAMILY (Brucella suis) |
PF13561(adh_short_C2) | 5 | LEU A 211VAL A 175GLY A 229THR A 207THR A 231 | None | 1.42A | 4mubA-4o6vA:2.7 | 4mubA-4o6vA:23.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4opf | NRPS/PKS (Streptomycesalbus) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | LEU A6198VAL A6223GLY A6218PHE A6261THR A6202 | None | 1.37A | 4mubA-4opfA:undetectable | 4mubA-4opfA:19.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rku | PHOTOSYSTEM I P700CHLOROPHYLL AAPOPROTEIN A1 (Pisum sativum) |
PF00223(PsaA_PsaB) | 5 | HIS A 545GLY A 366THR A 552MET A 400THR A 369 | CLA A1135 (-3.9A)NoneCLA A1124 (-3.5A)CLA A1124 (-3.6A)CLA A1127 (-3.3A) | 1.33A | 4mubA-4rkuA:undetectable | 4mubA-4rkuA:14.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rp8 | ASCORBATE-SPECIFICPERMEASE IICCOMPONENT ULAA (Escherichiacoli) |
PF03611(EIIC-GAT) | 5 | PRO A 355GLY A 273PHE A 330THR A 334THR A 272 | None | 0.99A | 4mubA-4rp8A:undetectable | 4mubA-4rp8A:18.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rvs | PROBABLE QUINONEREDUCTASE QOR(NADPH:QUINONEREDUCTASE)(ZETA-CRYSTALLINHOMOLOG PROTEIN) (Mycobacteriumtuberculosis) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | LEU A 134VAL A 148GLY A 222PHE A 242THR A 225 | None | 1.40A | 4mubA-4rvsA:undetectable | 4mubA-4rvsA:20.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4s13 | FERULIC ACIDDECARBOXYLASE 1 (Saccharomycescerevisiae) |
PF01977(UbiD) | 5 | PHE A 64VAL A 178GLY A 157PHE A 268THR A 155 | None | 1.36A | 4mubA-4s13A:undetectable | 4mubA-4s13A:20.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4s2t | PROTEIN APP-1 (Caenorhabditiselegans) |
PF00557(Peptidase_M24)PF01321(Creatinase_N)PF16188(Peptidase_M24_C)PF16189(Creatinase_N_2) | 5 | PHE P 556LEU P 559GLY P 448THR P 560THR P 470 | None | 1.35A | 4mubA-4s2tP:undetectable | 4mubA-4s2tP:17.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tv6 | 2-DEHYDRO-3-DEOXYGLUCARATE ALDOLASE (Staphylococcusaureus) |
PF03328(HpcH_HpaI) | 5 | PRO A 215PHE A 21LEU A 234PHE A 40MET A 149 | NoneNoneNoneNoneOAA A 301 ( 4.2A) | 1.17A | 4mubA-4tv6A:undetectable | 4mubA-4tv6A:17.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w8j | PESTICIDAL CRYSTALPROTEIN CRY1AC (Bacillusthuringiensis) |
PF00555(Endotoxin_M)PF03944(Endotoxin_C)PF03945(Endotoxin_N) | 5 | PRO A 271LEU A 383GLY A 357PHE A 388THR A 386 | None | 1.28A | 4mubA-4w8jA:undetectable | 4mubA-4w8jA:12.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xru | HEN1 (Capnocytophagagingivalis) |
no annotation | 5 | LEU C 199GLY C 419ASP C 420PHE C 244THR C 249 | None | 1.44A | 4mubA-4xruC:undetectable | 4mubA-4xruC:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zel | DOPAMINEBETA-HYDROXYLASE (Homo sapiens) |
PF01082(Cu2_monooxygen)PF03351(DOMON)PF03712(Cu2_monoox_C) | 5 | PHE A 74LEU A 145VAL A 101ASP A 130MET A 89 | None | 1.43A | 4mubA-4zelA:undetectable | 4mubA-4zelA:17.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ztk | CELL DIVISIONPROTEINFTSI/PENICILLINBINDING PROTEIN 2 (Legionellapneumophila) |
PF00905(Transpeptidase) | 5 | PRO A 588LEU A 631VAL A 565GLY A 616THR A 569 | NoneNoneNoneNoneNHE A 901 (-3.6A) | 1.45A | 4mubA-4ztkA:undetectable | 4mubA-4ztkA:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zv7 | LIPASE B (Moesziomycesantarcticus) |
no annotation | 5 | LEU A 73VAL A 154ASP A 134THR A 40THR A 164 | None | 1.45A | 4mubA-4zv7A:undetectable | 4mubA-4zv7A:19.43 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5byk | SULFOTRANSFERASE (Schistosomamansoni) |
no annotation | 5 | HIS A 37PHE A 39VAL A 127GLY A 143ASP A 144 | OAQ A 302 ( 4.6A)NoneOAQ A 302 (-4.9A)OAQ A 302 ( 4.1A)OAQ A 302 (-3.3A) | 1.12A | 4mubA-5bykA:44.7 | 4mubA-5bykA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5byk | SULFOTRANSFERASE (Schistosomamansoni) |
no annotation | 12 | PRO A 16HIS A 37MET A 38PHE A 39LEU A 92VAL A 128GLY A 143ASP A 144PHE A 153THR A 157MET A 233THR A 237 | OAQ A 302 (-4.4A)OAQ A 302 ( 4.6A)OAQ A 302 (-4.3A)NoneOAQ A 302 (-4.0A)OAQ A 302 (-4.0A)OAQ A 302 ( 4.1A)OAQ A 302 (-3.3A)OAQ A 302 ( 4.8A)OAQ A 302 (-2.6A)NoneOAQ A 302 (-3.8A) | 0.19A | 4mubA-5bykA:44.7 | 4mubA-5bykA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5byk | SULFOTRANSFERASE (Schistosomamansoni) |
no annotation | 6 | PRO A 16HIS A 37PHE A 39LEU A 92VAL A 128THR A 234 | OAQ A 302 (-4.4A)OAQ A 302 ( 4.6A)NoneOAQ A 302 (-4.0A)OAQ A 302 (-4.0A)None | 1.22A | 4mubA-5bykA:44.7 | 4mubA-5bykA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cx7 | ATP:COB(I)ALAMINADENOSYLTRANSFERASE (Salmonellaenterica) |
PF03928(Haem_degrading) | 5 | LEU A 20VAL A 37GLY A 125ASP A 130MET A 52 | NoneNoneGOL A 202 (-4.2A)GOL A 202 (-3.6A)None | 1.41A | 4mubA-5cx7A:undetectable | 4mubA-5cx7A:19.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cxp | POSSIBLE XYLANDEGRADATION ENZYME(GLYCOSYL HYDROLASEFAMILY 30-LIKEDOMAIN AND RICINB-LIKE DOMAIN) (Clostridiumacetobutylicum) |
PF02055(Glyco_hydro_30) | 5 | PRO A 89LEU A 107GLY A 205PHE A 158THR A 229 | None | 0.86A | 4mubA-5cxpA:undetectable | 4mubA-5cxpA:21.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cxp | POSSIBLE XYLANDEGRADATION ENZYME(GLYCOSYL HYDROLASEFAMILY 30-LIKEDOMAIN AND RICINB-LIKE DOMAIN) (Clostridiumacetobutylicum) |
PF02055(Glyco_hydro_30) | 5 | PRO A 89LEU A 107GLY A 206PHE A 158THR A 229 | None | 1.33A | 4mubA-5cxpA:undetectable | 4mubA-5cxpA:21.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cyr | RNA-DEPENDENT RNAPOLYMERASE (Thosea asignavirus) |
no annotation | 5 | PRO B 629PHE B 620LEU B 569VAL B 634GLY B 324 | None | 1.28A | 4mubA-5cyrB:undetectable | 4mubA-5cyrB:16.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cyr | RNA-DEPENDENT RNAPOLYMERASE (Thosea asignavirus) |
no annotation | 5 | PRO B 629PHE B 620LEU B 569VAL B 634GLY B 325 | None | 1.28A | 4mubA-5cyrB:undetectable | 4mubA-5cyrB:16.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5epg | ALDEHYDE OXIDASE (Homo sapiens) |
PF00111(Fer2)PF00941(FAD_binding_5)PF01315(Ald_Xan_dh_C)PF01799(Fer2_2)PF02738(Ald_Xan_dh_C2)PF03450(CO_deh_flav_C) | 5 | LEU A 31VAL A 54GLY A 146THR A 40MET A 352 | None | 1.07A | 4mubA-5epgA:undetectable | 4mubA-5epgA:10.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ham | RICKCE (Rickettsiabellii) |
no annotation | 5 | MET A 461LEU A 457GLY A 500ASP A 501THR A 455 | None | 1.26A | 4mubA-5hamA:undetectable | 4mubA-5hamA:23.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i4q | ELONGATION FACTOR TU (Escherichiacoli) |
PF03143(GTP_EFTU_D3)PF03144(GTP_EFTU_D2) | 5 | PHE C 323LEU C 312GLY C 340THR C 383MET C 359 | None | 1.22A | 4mubA-5i4qC:undetectable | 4mubA-5i4qC:19.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jki | PUTATIVE LIPIDPHOSPHATEPHOSPHATASE YODM (Bacillussubtilis) |
PF01569(PAP2) | 5 | VAL A 166GLY A 53PHE A 180MET A 46THR A 50 | None | 1.15A | 4mubA-5jkiA:undetectable | 4mubA-5jkiA:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jxr | CHROMATIN-REMODELINGCOMPLEX ATPASE-LIKEPROTEIN (Thermothelomycesthermophila) |
PF00176(SNF2_N)PF00271(Helicase_C) | 5 | PHE A 365LEU A 356GLY A 101PHE A 396THR A 103 | None | 1.38A | 4mubA-5jxrA:undetectable | 4mubA-5jxrA:16.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mil | DUTPASE FAMILYPROTEIN (Staphylococcusaureus) |
PF08761(dUTPase_2) | 5 | PHE A 41LEU A 47PHE A 50THR A 49MET A 112 | None | 1.40A | 4mubA-5milA:undetectable | 4mubA-5milA:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mzn | HELICASESEN1,HELICASE SEN1 (Saccharomycescerevisiae) |
PF13086(AAA_11)PF13087(AAA_12) | 5 | PHE A1811LEU A1818GLY A1615ASP A1616THR A1819 | EDO A2010 ( 2.9A)NoneNoneNoneNone | 1.28A | 4mubA-5mznA:undetectable | 4mubA-5mznA:16.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nsq | AMINOPEPTIDASE,PUTATIVE (Trypanosomabrucei) |
PF00883(Peptidase_M17) | 5 | LEU A 514VAL A 494GLY A 411PHE A 509THR A 410 | None | 0.96A | 4mubA-5nsqA:undetectable | 4mubA-5nsqA:19.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ntf | AMINOPEPTIDASE (Trypanosomacruzi) |
PF00883(Peptidase_M17) | 5 | LEU A 513VAL A 493GLY A 410PHE A 508THR A 409 | None | 0.98A | 4mubA-5ntfA:undetectable | 4mubA-5ntfA:17.99 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5tiw | SULFOTRANSFERASE (Schistosomahaematobium) |
no annotation | 5 | PRO A 31HIS A 52LEU A 101VAL A 137THR A 243 | OAQ A 302 (-4.7A)OAQ A 302 ( 4.9A)OAQ A 302 ( 4.1A)OAQ A 302 (-4.0A)None | 1.18A | 4mubA-5tiwA:39.6 | 4mubA-5tiwA:75.29 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5tiw | SULFOTRANSFERASE (Schistosomahaematobium) |
no annotation | 10 | PRO A 31HIS A 52MET A 53LEU A 101VAL A 137GLY A 152ASP A 153PHE A 162MET A 242THR A 246 | OAQ A 302 (-4.7A)OAQ A 302 ( 4.9A)OAQ A 302 (-4.5A)OAQ A 302 ( 4.1A)OAQ A 302 (-4.0A)OAQ A 302 ( 4.5A)OAQ A 302 (-3.1A)OAQ A 302 (-4.6A)OAQ A 302 ( 4.0A)OAQ A 302 (-3.5A) | 0.38A | 4mubA-5tiwA:39.6 | 4mubA-5tiwA:75.29 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5tiz | SULFOTRANSFERASE (Schistosomajaponicum) |
no annotation | 7 | PRO A 16HIS A 37MET A 38LEU A 88VAL A 124PHE A 149THR A 233 | None | 0.59A | 4mubA-5tizA:35.1 | 4mubA-5tizA:57.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u2p | SUGAR ABCTRANSPORTERSUBSTRATE-BINDINGPROTEIN (Treponemapallidum) |
PF01547(SBP_bac_1) | 5 | HIS A 278LEU A 308ASP A 385THR A 309THR A 193 | NoneNoneEDO A 504 (-2.3A)NoneNone | 1.44A | 4mubA-5u2pA:undetectable | 4mubA-5u2pA:20.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5usc | PREPHENATEDEHYDROGENASE (Bacillusanthracis) |
PF02153(PDH) | 5 | HIS A 161MET A 160GLY A 108ASP A 106THR A 110 | None | 1.14A | 4mubA-5uscA:undetectable | 4mubA-5uscA:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vxb | PROXP-ALA (Caulobactervibrioides) |
PF04073(tRNA_edit) | 5 | PRO A 156LEU A 149GLY A 63PHE A 129THR A 65 | None | 1.23A | 4mubA-5vxbA:undetectable | 4mubA-5vxbA:21.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xlu | GAMMA GLUTAMYLTRANSPEPTIDASE (Bacilluslicheniformis) |
no annotation | 5 | PRO A 338VAL A 343GLY A 373ASP A 330PHE A 293 | PRO A 338 ( 1.1A)VAL A 343 ( 0.5A)GLY A 373 ( 0.0A)ASP A 330 ( 0.5A)PHE A 293 ( 1.3A) | 1.45A | 4mubA-5xluA:undetectable | 4mubA-5xluA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xvi | GLUTAMATEDEHYDROGENASE (Aspergillusniger) |
no annotation | 5 | PHE A 265LEU A 272GLY A 255ASP A 252THR A 276 | None | 1.33A | 4mubA-5xviA:undetectable | 4mubA-5xviA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zmy | - (-) |
no annotation | 5 | PRO A 133HIS A 69LEU A 103GLY A 218THR A 212 | TAR A 401 (-4.3A) ZN A 400 ( 3.3A)NoneNoneNone | 1.42A | 4mubA-5zmyA:undetectable | 4mubA-5zmyA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6dd3 | CYTOSOLIC PURINE5'-NUCLEOTIDASE (Homo sapiens) |
no annotation | 5 | HIS A 209PHE A 157GLY A 350ASP A 356THR A 56 | NoneNoneNonePO4 A 601 ( 4.9A)None | 1.08A | 4mubA-6dd3A:undetectable | 4mubA-6dd3A:undetectable |