SIMILAR PATTERNS OF AMINO ACIDS FOR 4MS4_A_2C0A501_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bud PROTEIN (ACUTOLYSIN
A)


(Deinagkistrodon
acutus)
PF01421
(Reprolysin)
4 SER A 115
SER A 122
TYR A 189
ILE A 198
None
1.27A 4ms4A-1budA:
4.0
4ms4A-1budA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c8m HUMAN RHINOVIRUS 16
COAT PROTEIN


(Rhinovirus A)
PF00073
(Rhv)
4 TRP 2  79
SER 2 167
HIS 2 130
ILE 2 224
None
1.19A 4ms4A-1c8m2:
undetectable
4ms4A-1c8m2:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c9e PROTOHEME FERROLYASE

(Bacillus
subtilis)
PF00762
(Ferrochelatase)
4 SER A 121
HIS A 183
ILE A  29
GLU A 264
MP1  A 800 (-3.4A)
MP1  A 800 (-3.6A)
MP1  A 800 (-4.5A)
MP1  A 800 (-4.3A)
0.97A 4ms4A-1c9eA:
3.9
4ms4A-1c9eA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fnn CELL DIVISION
CONTROL PROTEIN 6


(Pyrobaculum
aerophilum)
PF09079
(Cdc6_C)
PF13401
(AAA_22)
4 SER A 269
SER A 249
ILE A 218
GLU A 264
None
1.35A 4ms4A-1fnnA:
undetectable
4ms4A-1fnnA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h54 MALTOSE
PHOSPHORYLASE


(Lactobacillus
brevis)
PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N)
4 HIS A 555
TYR A 619
ILE A 563
GLU A 489
None
None
None
K  A1754 (-2.6A)
1.19A 4ms4A-1h54A:
undetectable
4ms4A-1h54A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hfh FACTOR H, 15TH AND
16TH C-MODULE PAIR


(Homo sapiens)
PF00084
(Sushi)
4 HIS A  13
TYR A  34
ILE A  42
GLU A  12
None
1.36A 4ms4A-1hfhA:
undetectable
4ms4A-1hfhA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hlk BETA-LACTAMASE, TYPE
II


(Bacteroides
fragilis)
no annotation 4 SER A  42
SER A  54
HIS A 223
ILE A  46
NA  A2001 ( 4.6A)
NA  A2001 ( 4.9A)
113  A2002 ( 3.6A)
113  A2002 (-4.1A)
1.35A 4ms4A-1hlkA:
undetectable
4ms4A-1hlkA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k32 TRICORN PROTEASE

(Thermoplasma
acidophilum)
PF03572
(Peptidase_S41)
PF07676
(PD40)
PF14684
(Tricorn_C1)
PF14685
(Tricorn_PDZ)
4 SER A 965
TYR A 748
ILE A 994
GLU A1023
None
1.14A 4ms4A-1k32A:
3.4
4ms4A-1k32A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ko0 DIAMINOPIMELATE
DECARBOXYLASE


(Escherichia
coli)
PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N)
4 SER A 134
SER A 113
ILE A 104
GLU A 110
None
1.23A 4ms4A-1ko0A:
undetectable
4ms4A-1ko0A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kq0 METHIONINE
AMINOPEPTIDASE 2


(Homo sapiens)
PF00557
(Peptidase_M24)
4 TRP A 419
SER A 381
ILE A 194
GLU A 201
None
1.27A 4ms4A-1kq0A:
undetectable
4ms4A-1kq0A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kzh PHOSPHOFRUCTOKINASE

(Borreliella
burgdorferi)
PF00365
(PFK)
4 SER A 256
SER A 274
ILE A 287
GLU A 276
None
1.23A 4ms4A-1kzhA:
1.8
4ms4A-1kzhA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l8k T-CELL
PROTEIN-TYROSINE
PHOSPHATASE


(Homo sapiens)
PF00102
(Y_phosphatase)
4 SER A 202
SER A 204
HIS A 209
ILE A 172
None
1.14A 4ms4A-1l8kA:
undetectable
4ms4A-1l8kA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nbw GLYCEROL DEHYDRATASE
REACTIVASE ALPHA
SUBUNIT


(Klebsiella
pneumoniae)
PF08841
(DDR)
4 SER A 245
HIS A 100
ILE A 164
GLU A 352
None
1.35A 4ms4A-1nbwA:
undetectable
4ms4A-1nbwA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgj 6-PHOSPHOGLUCONATE
DEHYDROGENASE


(Trypanosoma
brucei)
PF00393
(6PGD)
PF03446
(NAD_binding_2)
4 SER A 431
SER A 339
TYR A 410
ILE A 403
None
1.31A 4ms4A-1pgjA:
4.1
4ms4A-1pgjA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1a HST2 PROTEIN

(Saccharomyces
cerevisiae)
PF02146
(SIR2)
4 SER A 270
HIS A  97
ILE A  41
GLU A 121
OAD  A1001 (-3.5A)
None
None
None
1.22A 4ms4A-1q1aA:
3.5
4ms4A-1q1aA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qdm PROPHYTEPSIN

(Hordeum vulgare)
PF00026
(Asp)
PF03489
(SapB_2)
PF05184
(SapB_1)
4 SER A  40
SER A 134
TYR A 143
GLU A 105
None
1.35A 4ms4A-1qdmA:
undetectable
4ms4A-1qdmA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rpm RECEPTOR PROTEIN
TYROSINE PHOSPHATASE
MU


(Homo sapiens)
PF00102
(Y_phosphatase)
4 SER A1084
SER A 993
ILE A1037
GLU A1052
None
1.19A 4ms4A-1rpmA:
2.5
4ms4A-1rpmA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wta 5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE


(Aeropyrum
pernix)
PF01048
(PNP_UDP_1)
4 SER A  95
SER A  93
TYR A 167
ILE A 201
PO4  A 400 (-2.8A)
None
None
None
1.09A 4ms4A-1wtaA:
2.4
4ms4A-1wtaA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x7p RRNA
METHYLTRANSFERASE


(Streptomyces
viridochromogenes)
PF00588
(SpoU_methylase)
4 SER A 176
SER A 179
HIS A  55
GLU A  54
None
1.22A 4ms4A-1x7pA:
3.4
4ms4A-1x7pA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yt8 THIOSULFATE
SULFURTRANSFERASE


(Pseudomonas
aeruginosa)
PF00581
(Rhodanese)
4 SER A  49
SER A 418
ILE A 487
GLU A  73
None
1.19A 4ms4A-1yt8A:
3.0
4ms4A-1yt8A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z8l GLUTAMATE
CARBOXYPEPTIDASE II


(Homo sapiens)
PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28)
4 SER A 483
SER A 496
TYR A 537
GLU A 486
None
None
None
NAG  A1757 (-2.7A)
1.20A 4ms4A-1z8lA:
3.4
4ms4A-1z8lA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2adu METHIONINE
AMINOPEPTIDASE 2


(Homo sapiens)
PF00557
(Peptidase_M24)
4 TRP A 419
SER A 381
ILE A 194
GLU A 201
None
1.23A 4ms4A-2aduA:
undetectable
4ms4A-2aduA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c5u RNA LIGASE

(Escherichia
virus T4)
PF09511
(RNA_lig_T4_1)
4 SER A  26
SER A  28
TYR A 108
GLU A 113
None
1.18A 4ms4A-2c5uA:
undetectable
4ms4A-2c5uA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2edj ROUNDABOUT HOMOLOG 2

(Homo sapiens)
PF07679
(I-set)
4 SER A  85
SER A  83
ILE A  10
GLU A  87
None
1.22A 4ms4A-2edjA:
undetectable
4ms4A-2edjA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2a ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT C


(Staphylococcus
aureus)
PF02637
(GatB_Yqey)
PF02686
(Glu-tRNAGln)
PF02934
(GatB_N)
4 SER B 130
SER B 137
TYR B  83
ILE C  94
None
1.19A 4ms4A-2f2aB:
undetectable
4ms4A-2f2aB:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ggs 273AA LONG
HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE REDUCTASE


(Sulfurisphaera
tokodaii)
PF04321
(RmlD_sub_bind)
4 SER A  21
SER A  17
ILE A  35
GLU A  15
None
1.36A 4ms4A-2ggsA:
4.6
4ms4A-2ggsA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsk VITAMIN B12
TRANSPORTER BTUB


(Escherichia
coli)
PF00593
(TonB_dep_Rec)
PF07715
(Plug)
4 SER A 392
SER A 415
ILE A 461
GLU A 413
None
1.27A 4ms4A-2gskA:
undetectable
4ms4A-2gskA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h31 MULTIFUNCTIONAL
PROTEIN ADE2


(Homo sapiens)
PF00731
(AIRC)
PF01259
(SAICAR_synt)
4 SER A 400
SER A 179
HIS A 396
ILE A  64
None
1.29A 4ms4A-2h31A:
9.1
4ms4A-2h31A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i2w PHOSPHOHEPTOSE
ISOMERASE


(Escherichia
coli)
PF13580
(SIS_2)
4 SER A 121
SER A 119
ILE A 128
GLU A 159
None
1.34A 4ms4A-2i2wA:
3.9
4ms4A-2i2wA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2krf TRANSCRIPTIONAL
REGULATORY PROTEIN
COMA


(Bacillus
subtilis)
PF00196
(GerE)
4 SER A 191
SER A 188
ILE A 174
GLU A 186
None
1.34A 4ms4A-2krfA:
undetectable
4ms4A-2krfA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ooq RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE T


(Homo sapiens)
PF00102
(Y_phosphatase)
4 SER A 945
SER A 949
HIS A 948
ILE A 970
None
1.16A 4ms4A-2ooqA:
2.5
4ms4A-2ooqA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2


(Homo sapiens)
PF00069
(Pkinase)
4 SER X 169
TYR X 194
ILE X 202
GLU X 165
None
1.36A 4ms4A-2p3gX:
undetectable
4ms4A-2p3gX:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6r AFUHEL308 HELICASE

(Archaeoglobus
fulgidus)
PF00270
(DEAD)
PF00271
(Helicase_C)
4 SER A 544
HIS A 512
ILE A 495
GLU A 560
None
1.28A 4ms4A-2p6rA:
2.9
4ms4A-2p6rA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po2 PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2


(Pyrococcus
abyssi)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
4 SER B 232
SER B 117
ILE B 158
GLU B 227
None
None
None
MPD  B 280 (-4.1A)
1.30A 4ms4A-2po2B:
undetectable
4ms4A-2po2B:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ps2 PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME


(Aspergillus
oryzae)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 SER A  53
SER A 271
ILE A  61
GLU A 102
None
1.06A 4ms4A-2ps2A:
3.2
4ms4A-2ps2A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qtk PROBABLE PORIN

(Pseudomonas
aeruginosa)
PF03573
(OprD)
4 TRP A 275
SER A 170
TYR A 206
ILE A 244
None
1.29A 4ms4A-2qtkA:
undetectable
4ms4A-2qtkA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1


(Homo sapiens)
PF00069
(Pkinase)
4 SER A 263
SER A 242
ILE A 195
GLU A 258
None
1.32A 4ms4A-2v55A:
undetectable
4ms4A-2v55A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xn1 ALPHA-GALACTOSIDASE

(Lactobacillus
acidophilus)
PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N)
4 SER A 228
TYR A 570
ILE A 548
GLU A 206
None
1.11A 4ms4A-2xn1A:
undetectable
4ms4A-2xn1A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK


([Ruminococcus]
gnavus)
PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N)
4 SER A 224
TYR A 558
ILE A 536
GLU A 202
None
1.01A 4ms4A-2yfnA:
undetectable
4ms4A-2yfnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5k TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 1


(Homo sapiens)
PF00102
(Y_phosphatase)
4 SER A 201
SER A 203
HIS A 208
ILE A 171
None
1.14A 4ms4A-3a5kA:
2.5
4ms4A-3a5kA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c75 AMICYANIN
METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN
METHYLAMINE
DEHYDROGENASE LIGHT
CHAIN


(Paracoccus
versutus)
PF00127
(Copper-bind)
PF02975
(Me-amine-dh_L)
PF06433
(Me-amine-dh_H)
4 HIS A  96
TYR H 222
ILE L 106
GLU L 101
CU  A 107 (-3.3A)
None
None
None
1.21A 4ms4A-3c75A:
undetectable
4ms4A-3c75A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dp9 MTA/SAH NUCLEOSIDASE

(Vibrio cholerae)
PF01048
(PNP_UDP_1)
4 SER A 197
SER A  76
ILE A  50
GLU A 173
BIG  A 301 (-3.3A)
BIG  A 301 (-3.3A)
BIG  A 301 (-3.8A)
None
1.18A 4ms4A-3dp9A:
2.9
4ms4A-3dp9A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dra GERANYLGERANYLTRANSF
ERASE TYPE I BETA
SUBUNIT
PROTEIN
FARNESYLTRANSFERASE/
GERANYLGERANYLTRANSF
ERASE TYPE-1 SUBUNIT
ALPHA


(Candida
albicans)
PF00432
(Prenyltrans)
PF01239
(PPTA)
4 TRP A 296
SER A 258
HIS B 249
ILE A 291
None
1.33A 4ms4A-3draA:
undetectable
4ms4A-3draA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e59 PYOVERDINE
BIOSYNTHESIS PROTEIN
PVCA


(Pseudomonas
aeruginosa)
PF05141
(DIT1_PvcA)
4 TRP A 279
SER A 112
TYR A 131
ILE A 128
None
1.29A 4ms4A-3e59A:
undetectable
4ms4A-3e59A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fbt CHORISMATE MUTASE
AND SHIKIMATE
5-DEHYDROGENASE
FUSION PROTEIN


(Clostridium
acetobutylicum)
PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N)
4 SER A 111
HIS A 110
TYR A 308
ILE A 116
None
1.24A 4ms4A-3fbtA:
2.4
4ms4A-3fbtA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgt PUTATIVE
PHOSPHOLIPASE B-LIKE
2 40 KDA FORM


(Mus musculus)
PF04916
(Phospholip_B)
4 SER B 305
HIS B 266
TYR B 307
GLU B 328
None
OCS  B 249 ( 4.3A)
None
NA  B 606 (-2.7A)
1.27A 4ms4A-3fgtB:
undetectable
4ms4A-3fgtB:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgt PUTATIVE
PHOSPHOLIPASE B-LIKE
2 40 KDA FORM


(Mus musculus)
PF04916
(Phospholip_B)
4 SER B 305
HIS B 266
TYR B 307
ILE B 536
None
OCS  B 249 ( 4.3A)
None
None
1.35A 4ms4A-3fgtB:
undetectable
4ms4A-3fgtB:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgw PUTATIVE
PHOSPHOLIPASE B-LIKE
2


(Mus musculus)
PF04916
(Phospholip_B)
4 SER A 305
HIS A 266
TYR A 307
GLU A 328
None
None
None
NA  A 610 (-3.1A)
1.28A 4ms4A-3fgwA:
undetectable
4ms4A-3fgwA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k5j SUPPRESSOR OF FUSED
FAMILY PROTEIN


(Neisseria
gonorrhoeae)
PF05076
(SUFU)
4 SER A  70
HIS A  77
ILE A 172
GLU A  76
None
0.99A 4ms4A-3k5jA:
undetectable
4ms4A-3k5jA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n5f N-CARBAMOYL-L-AMINO
ACID HYDROLASE


(Geobacillus
stearothermophilus)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
4 SER A  78
HIS A  79
ILE A 190
GLU A 125
CO  A 410 ( 4.7A)
CO  A 410 (-3.2A)
None
CO  A 410 ( 4.7A)
1.15A 4ms4A-3n5fA:
2.0
4ms4A-3n5fA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6n RNA-DEPENDENT RNA
POLYMERASE


(Enterovirus A)
PF00680
(RdRP_1)
4 SER A 295
SER A 292
TYR A 327
GLU A 108
None
1.35A 4ms4A-3n6nA:
undetectable
4ms4A-3n6nA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nkh INTEGRASE

(Staphylococcus
aureus)
PF00589
(Phage_integrase)
4 SER A 197
SER A  -2
HIS A 201
GLU A 204
None
1.06A 4ms4A-3nkhA:
undetectable
4ms4A-3nkhA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s1s RESTRICTION
ENDONUCLEASE BPUSI


(Bacillus
pumilus)
PF02384
(N6_Mtase)
PF15516
(BpuSI_N)
4 SER A 762
HIS A 727
ILE A 819
GLU A 745
None
1.23A 4ms4A-3s1sA:
4.3
4ms4A-3s1sA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t66 NICKEL ABC
TRANSPORTER
(NICKEL-BINDING
PROTEIN)


(Bacillus
halodurans)
PF00496
(SBP_bac_5)
4 SER A 385
HIS A 242
TYR A 337
GLU A 342
None
1.27A 4ms4A-3t66A:
2.1
4ms4A-3t66A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thz DNA MISMATCH REPAIR
PROTEIN MSH2


(Homo sapiens)
PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III)
4 SER A 738
SER A 734
ILE A 216
GLU A 731
None
1.25A 4ms4A-3thzA:
undetectable
4ms4A-3thzA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tia NEURAMINIDASE

(Influenza A
virus)
PF00064
(Neur)
4 SER A 228
SER A 279
TYR A 423
TRP A 352
None
1.14A 4ms4A-3tiaA:
undetectable
4ms4A-3tiaA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tny YFIY (ABC TRANSPORT
SYSTEM
SUBSTRATE-BINDING
PROTEIN)


(Bacillus cereus)
PF01497
(Peripla_BP_2)
4 HIS A  92
TYR A 122
ILE A  24
GLU A  69
None
1.04A 4ms4A-3tnyA:
3.1
4ms4A-3tnyA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tny YFIY (ABC TRANSPORT
SYSTEM
SUBSTRATE-BINDING
PROTEIN)


(Bacillus cereus)
PF01497
(Peripla_BP_2)
4 SER A 108
HIS A  92
ILE A  24
GLU A  69
None
1.22A 4ms4A-3tnyA:
3.1
4ms4A-3tnyA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8u TRANSFERRIN
BINDING-PROTEIN B


(Neisseria
meningitidis)
PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A)
4 SER A 137
SER A 344
TYR A 103
GLU A 327
None
1.20A 4ms4A-3v8uA:
undetectable
4ms4A-3v8uA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9f TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE/RESPONSE
REGULATOR, HYBRID
(ONE-COMPONENT
SYSTEM)


(Bacteroides
thetaiotaomicron)
PF07494
(Reg_prop)
PF07495
(Y_Y_Y)
4 SER A  34
TYR A  69
ILE A  80
GLU A  84
None
0.87A 4ms4A-3v9fA:
undetectable
4ms4A-3v9fA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ve2 TRANSFERRIN-BINDING
PROTEIN 2


(Neisseria
meningitidis)
PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A)
4 SER A 137
SER A 343
TYR A 104
GLU A 326
None
1.16A 4ms4A-3ve2A:
undetectable
4ms4A-3ve2A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btg MAJOR INNER PROTEIN
P1


(Pseudomonas
virus phi6)
no annotation 4 SER A 741
SER A 739
TYR A 637
ILE A 633
None
1.26A 4ms4A-4btgA:
undetectable
4ms4A-4btgA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl0 AMINOTRANSFERASE
ALD1


(Arabidopsis
thaliana)
PF00155
(Aminotran_1_2)
4 SER A 252
SER A 280
TYR A 126
ILE A 121
None
1.34A 4ms4A-4fl0A:
3.0
4ms4A-4fl0A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h53 NEURAMINIDASE

(Influenza A
virus)
PF00064
(Neur)
4 SER A 228
SER A 279
TYR A 423
TRP A 352
None
1.14A 4ms4A-4h53A:
undetectable
4ms4A-4h53A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4het HYPOTHETICAL
GLYCOSIDE HYDROLASE


(Bacteroides
thetaiotaomicron)
PF13201
(PCMD)
4 SER A 347
SER A 349
ILE A 209
GLU A 194
None
1.26A 4ms4A-4hetA:
undetectable
4ms4A-4hetA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9w PROLINE RACEMASE
FAMILY PROTEIN


(Pseudomonas
protegens)
PF05544
(Pro_racemase)
4 SER A   9
SER A  98
ILE A  20
GLU A 293
None
1.34A 4ms4A-4j9wA:
undetectable
4ms4A-4j9wA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k05 CONSERVED
HYPOTHETICAL
EXPORTED PROTEIN


(Bacteroides
fragilis)
PF07075
(DUF1343)
4 SER A 255
HIS A  94
TYR A 267
GLU A  93
None
1.36A 4ms4A-4k05A:
4.4
4ms4A-4k05A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf7 NUP188

(Thermothelomyces
thermophila)
PF10487
(Nup188)
4 SER A 512
SER A 559
TYR A 579
ILE A 613
None
1.19A 4ms4A-4kf7A:
undetectable
4ms4A-4kf7A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kn5 METHYLTHIOADENOSINE
NUCLEOSIDASE


(Weissella
paramesenteroides)
PF01048
(PNP_UDP_1)
4 SER A 219
SER A  74
TYR A 133
ILE A  91
None
1.25A 4ms4A-4kn5A:
4.7
4ms4A-4kn5A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4koa 1,5-ANHYDRO-D-FRUCTO
SE REDUCTASE


(Sinorhizobium
meliloti)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
4 SER A  70
SER A  10
ILE A  18
GLU A  15
NDP  A 500 (-4.9A)
NDP  A 500 (-3.9A)
None
None
1.36A 4ms4A-4koaA:
5.1
4ms4A-4koaA:
24.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mrm GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1


(Homo sapiens)
PF01094
(ANF_receptor)
5 TRP A  65
SER A 130
SER A 153
HIS A 170
GLU A 349
2BY  A 501 (-3.6A)
2BY  A 501 (-3.0A)
2BY  A 501 (-2.6A)
2BY  A 501 (-4.1A)
2BY  A 501 (-3.5A)
0.22A 4ms4A-4mrmA:
58.0
4ms4A-4mrmA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n54 INOSITOL
DEHYDROGENASE


(Lactobacillus
casei)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
4 SER A  78
HIS A  81
ILE A 185
GLU A  98
NAI  A 401 (-3.1A)
NAI  A 401 (-4.0A)
None
NAI  A 401 (-3.3A)
1.03A 4ms4A-4n54A:
5.2
4ms4A-4n54A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nmn REPLICATIVE DNA
HELICASE


(Aquifex
aeolicus)
PF00772
(DnaB)
PF03796
(DnaB_C)
4 SER A 275
SER A 252
ILE A 264
GLU A 267
None
1.25A 4ms4A-4nmnA:
3.7
4ms4A-4nmnA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p2l SULFHYDRYL OXIDASE 1

(Rattus
norvegicus)
PF00085
(Thioredoxin)
PF04777
(Evr1_Alr)
4 SER A 472
SER A 474
HIS A 422
GLU A 426
None
1.13A 4ms4A-4p2lA:
undetectable
4ms4A-4p2lA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p7w L-PROLINE
CIS-4-HYDROXYLASE


(Mesorhizobium
japonicum)
PF05118
(Asp_Arg_Hydrox)
PF05373
(Pro_3_hydrox_C)
4 SER A 155
HIS A 106
ILE A  97
TRP A  40
None
CO  A 301 ( 3.3A)
None
AKG  A 302 (-4.2A)
1.09A 4ms4A-4p7wA:
undetectable
4ms4A-4p7wA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q28 PERIPLAKIN

(Homo sapiens)
PF00681
(Plectin)
4 SER A1652
HIS A1650
TYR A1738
GLU A1706
None
1.36A 4ms4A-4q28A:
undetectable
4ms4A-4q28A:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tr6 DNA POLYMERASE III
SUBUNIT BETA


(Bacillus
subtilis)
PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3)
4 SER A  49
SER A  54
TYR A 125
GLU A  56
None
1.25A 4ms4A-4tr6A:
undetectable
4ms4A-4tr6A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xzw ENDO-GLUCANASE
CHIMERA C10


(Geobacillus sp.
70PC53;
uncultured
bacterium)
PF00150
(Cellulase)
4 SER A 234
SER A 273
TRP A 264
GLU A 230
None
None
EPE  A 404 ( 4.1A)
EPE  A 404 (-4.3A)
1.30A 4ms4A-4xzwA:
undetectable
4ms4A-4xzwA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d2j 4-OXALOCROTONATE
DECARBOXYLASE NAHK


(Pseudomonas
putida)
no annotation 4 SER A 164
SER A 146
HIS A 105
ILE A  27
0L1  A 303 (-2.6A)
0L1  A 303 ( 4.7A)
None
None
1.29A 4ms4A-5d2jA:
undetectable
4ms4A-5d2jA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dt5 BETA-GLUCOSIDASE

(Exiguobacterium
antarcticum)
PF00232
(Glyco_hydro_1)
4 TRP A 118
SER A 170
ILE A  31
TRP A  32
None
1.23A 4ms4A-5dt5A:
undetectable
4ms4A-5dt5A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fip GH5 CELLULASE

(unidentified)
PF00150
(Cellulase)
PF03424
(CBM_17_28)
4 SER A 257
SER A 238
ILE A 154
GLU A 294
None
1.23A 4ms4A-5fipA:
2.1
4ms4A-5fipA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6


(Homo sapiens)
PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition)
4 SER B1025
HIS B1205
TYR B1029
GLU B1067
None
1.12A 4ms4A-5gjeB:
undetectable
4ms4A-5gjeB:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h1k GEM-ASSOCIATED
PROTEIN 5


(Homo sapiens)
PF00400
(WD40)
PF12894
(ANAPC4_WD40)
4 SER A 200
HIS A 194
ILE A 253
TRP A 254
None
1.06A 4ms4A-5h1kA:
undetectable
4ms4A-5h1kA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E


(Escherichia
coli)
PF01636
(APH)
4 SER A 221
HIS A 205
TYR A  36
ILE A  38
GDP  A 401 ( 4.7A)
GDP  A 401 (-4.4A)
None
GDP  A 401 (-4.2A)
1.21A 4ms4A-5igpA:
undetectable
4ms4A-5igpA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrw POTASSIUM-TRANSPORTI
NG ATPASE
ATP-BINDING SUBUNIT


(Escherichia
coli)
PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase)
4 SER B 384
SER B 341
ILE B 443
GLU B 348
None
1.30A 4ms4A-5mrwB:
4.3
4ms4A-5mrwB:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE


(Trypanosoma
brucei)
no annotation 4 SER A 585
HIS A 545
TYR A 593
ILE A 257
None
0.83A 4ms4A-5nfhA:
3.2
4ms4A-5nfhA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nnz DYNEIN ASSEMBLY
FACTOR WITH WDR
REPEAT DOMAINS 1


(Homo sapiens)
no annotation 4 SER B 392
HIS B 386
ILE B 413
TRP B 414
None
1.33A 4ms4A-5nnzB:
undetectable
4ms4A-5nnzB:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nuv AUTOPHAGY-RELATED
PROTEIN 16-1


(Homo sapiens)
PF00400
(WD40)
4 TRP A 435
SER A 390
HIS A 407
ILE A 455
None
1.11A 4ms4A-5nuvA:
undetectable
4ms4A-5nuvA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ue1 5'-METHYLTHIOADENOSI
NE/S-ADENOSYLHOMOCYS
TEINE NUCLEOSIDASE


(Aliivibrio
fischeri)
PF01048
(PNP_UDP_1)
4 SER A 197
SER A  76
ILE A  50
GLU A 173
9DA  A 301 (-3.2A)
TRS  A 302 (-2.8A)
TRS  A 302 ( 4.8A)
TRS  A 302 ( 4.6A)
1.11A 4ms4A-5ue1A:
2.6
4ms4A-5ue1A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujw TRIOSEPHOSPHATE
ISOMERASE


(Francisella
tularensis)
PF00121
(TIM)
4 SER A  98
SER A  94
HIS A  93
ILE A 170
None
None
None
13P  A 301 ( 4.6A)
1.19A 4ms4A-5ujwA:
undetectable
4ms4A-5ujwA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ur2 BIFUNCTIONAL PROTEIN
PUTA


(Bdellovibrio
bacteriovorus)
PF00171
(Aldedh)
PF01619
(Pro_dh)
4 SER A 907
SER A 909
HIS A  70
GLU A  66
None
1.10A 4ms4A-5ur2A:
2.6
4ms4A-5ur2A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7p OXAC

(Penicillium
oxalicum)
no annotation 4 SER A 245
HIS A 277
TYR A 198
GLU A 276
SAM  A 501 (-3.5A)
None
SAM  A 501 (-4.8A)
None
0.99A 4ms4A-5w7pA:
3.6
4ms4A-5w7pA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wru PROBABLE INORGANIC
PYROPHOSPHATASE


(Plasmodium
falciparum)
no annotation 4 SER A 109
HIS A 112
ILE A 139
TRP A 111
None
1.33A 4ms4A-5wruA:
undetectable
4ms4A-5wruA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zln TOLL-LIKE RECEPTOR 9

(Mus musculus)
no annotation 4 SER A 149
SER A 131
ILE A  71
TRP A  96
None
1.33A 4ms4A-5zlnA:
undetectable
4ms4A-5zlnA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6br6 NEURAMINIDASE

(Influenza A
virus)
no annotation 4 SER A 228
SER A 279
TYR A 423
TRP A 352
None
1.11A 4ms4A-6br6A:
undetectable
4ms4A-6br6A:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6br9 PROTEIN A6 HOMOLOG

(Fowlpox virus)
no annotation 4 SER A 272
SER A 268
TYR A 348
ILE A 225
None
1.19A 4ms4A-6br9A:
undetectable
4ms4A-6br9A:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cwo RIBONUCLEOTIDE
REDUCTASE


(Flavobacterium
johnsoniae)
no annotation 4 TRP A  30
HIS A 100
TYR A  29
ILE A  25
None
MN  A 401 (-3.5A)
None
None
1.00A 4ms4A-6cwoA:
undetectable
4ms4A-6cwoA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cwp RIBONUCLEOTIDE
REDUCTASE


(Flavobacterium
johnsoniae)
no annotation 4 TRP A  30
HIS A 100
TYR A  29
ILE A  25
None
MN  A 401 (-3.3A)
None
None
0.99A 4ms4A-6cwpA:
undetectable
4ms4A-6cwpA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emr -

(-)
no annotation 4 SER A 350
SER A 347
TRP A 344
GLU A 345
None
1.35A 4ms4A-6emrA:
undetectable
4ms4A-6emrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4


(Mus musculus)
no annotation 4 SER M 292
HIS M 293
ILE M 402
GLU M 378
None
1.14A 4ms4A-6g2jM:
undetectable
4ms4A-6g2jM:
13.31