SIMILAR PATTERNS OF AMINO ACIDS FOR 4MMF_B_29QB603_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bev | BOVINE ENTEROVIRUSCOAT PROTEINS VP1 TOVP4 (Enterovirus E) |
PF00073(Rhv) | 5 | ALA 1 254GLY 3 63PHE 2 156SER 1 268GLY 1 266 | None | 0.98A | 4mmfB-1bev1:undetectable | 4mmfB-1bev1:18.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cen | CELLULASE CELC (Ruminiclostridiumthermocellum) |
PF00150(Cellulase) | 5 | ASP A 43VAL A 86ALA A 134GLY A 309SER A 3 | None | 1.24A | 4mmfB-1cenA:undetectable | 4mmfB-1cenA:21.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dbi | AK.1 SERINE PROTEASE (Bacillus sp.Ak1) |
PF00082(Peptidase_S8) | 5 | ASP A 48VAL A 211ALA A 220TYR A 219GLY A 92 | CA A 701 (-2.2A)NoneNoneNoneNone | 1.02A | 4mmfB-1dbiA:undetectable | 4mmfB-1dbiA:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dot | DUCK OVOTRANSFERRIN (Anasplatyrhynchos) |
PF00405(Transferrin) | 5 | VAL A 399ALA A 402GLY A 412PHE A 656SER A 393 | None | 1.38A | 4mmfB-1dotA:0.0 | 4mmfB-1dotA:22.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e3j | NADP(H)-DEPENDENTKETOSE REDUCTASE (Bemisiaargentifolii) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | VAL A 219ALA A 199GLY A 257SER A 248GLY A 176 | NonePO4 A 903 (-3.4A)NoneNonePO4 A 903 ( 3.9A) | 1.20A | 4mmfB-1e3jA:0.0 | 4mmfB-1e3jA:21.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fi8 | ECOTINNATURAL KILLER CELLPROTEASE 1 (Escherichiacoli;Rattusnorvegicus) |
PF00089(Trypsin)PF03974(Ecotin) | 5 | ASP C 84VAL A 138GLY A 142SER A 195GLY A 197 | None | 1.14A | 4mmfB-1fi8C:undetectable | 4mmfB-1fi8C:10.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h76 | SEROTRANSFERRIN (Sus scrofa) |
PF00405(Transferrin) | 5 | VAL A 206ALA A 207GLY A 113SER A 156GLY A 204 | None | 1.22A | 4mmfB-1h76A:0.0 | 4mmfB-1h76A:20.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hzf | COMPLEMENT FACTORC4A (Homo sapiens) |
PF07678(A2M_comp)PF10569(Thiol-ester_cl) | 5 | ALA A1005TYR A1008GLY A1274PHE A1280SER A 977 | None | 0.87A | 4mmfB-1hzfA:1.5 | 4mmfB-1hzfA:21.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i36 | CONSERVEDHYPOTHETICAL PROTEINMTH1747 (Methanothermobacterthermautotrophicus) |
PF03807(F420_oxidored)PF09130(DUF1932) | 5 | ASP A 86VAL A 11ALA A 12SER A 62GLY A 7 | NoneNAP A1350 (-3.8A)NoneNoneNAP A1350 (-3.4A) | 1.13A | 4mmfB-1i36A:undetectable | 4mmfB-1i36A:20.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jkm | BREFELDIN A ESTERASE (Bacillussubtilis) |
PF07859(Abhydrolase_3) | 5 | VAL A 269ALA A 266TYR A 238GLY A 127GLY A 264 | None | 1.35A | 4mmfB-1jkmA:0.0 | 4mmfB-1jkmA:22.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m1j | FIBRINOGEN BETACHAIN (Gallus gallus) |
PF00147(Fibrinogen_C)PF08702(Fib_alpha) | 5 | ASP B 246VAL B 243TYR B 244GLY B 253SER B 227 | None | 1.23A | 4mmfB-1m1jB:undetectable | 4mmfB-1m1jB:19.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mn6 | POLYKETIDE SYNTHASEIV (Streptomycesvenezuelae) |
PF00975(Thioesterase) | 5 | ASP A 207VAL A 31ALA A 33PHE A 28GLY A 214 | None | 1.17A | 4mmfB-1mn6A:0.0 | 4mmfB-1mn6A:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n76 | LACTOFERRIN (Homo sapiens) |
PF00405(Transferrin) | 5 | VAL A 542ALA A 543GLY A 455SER A 492GLY A 540 | None | 1.21A | 4mmfB-1n76A:undetectable | 4mmfB-1n76A:21.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1s4e | GALACTOKINASE (Pyrococcusfuriosus) |
PF00288(GHMP_kinases_N)PF08544(GHMP_kinases_C)PF10509(GalKase_gal_bdg) | 5 | VAL A 155ALA A 154GLY A 351SER A 347GLY A 158 | None | 1.30A | 4mmfB-1s4eA:undetectable | 4mmfB-1s4eA:21.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tki | TITIN (Homo sapiens) |
PF00069(Pkinase) | 5 | ASP A 144VAL A 191ALA A 188TYR A 187GLY A 141 | None | 1.30A | 4mmfB-1tkiA:undetectable | 4mmfB-1tkiA:19.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u9c | APC35852 (Geobacillusstearothermophilus) |
PF01965(DJ-1_PfpI) | 5 | VAL A 192GLY A 184PHE A 190SER A 151GLY A 200 | None | 1.17A | 4mmfB-1u9cA:undetectable | 4mmfB-1u9cA:18.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vdk | FUMARATE HYDRATASECLASS II (Thermusthermophilus) |
PF00206(Lyase_1)PF10415(FumaraseC_C) | 5 | ASP A 142VAL A 246ALA A 247GLY A 137PHE A 242 | None | 1.19A | 4mmfB-1vdkA:1.0 | 4mmfB-1vdkA:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w0m | TRIOSEPHOSPHATEISOMERASE (Thermoproteustenax) |
PF00121(TIM)PF05690(ThiG) | 5 | VAL A 89ALA A 61TYR A 60GLY A 114GLY A 86 | None | 1.21A | 4mmfB-1w0mA:undetectable | 4mmfB-1w0mA:19.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xhl | SHORT-CHAINDEHYDROGENASE/REDUCTASE FAMILY MEMBER(5L265), PUTATIVETROPINONEREDUCTASE-II (Caenorhabditiselegans) |
PF13561(adh_short_C2) | 5 | ASP A 168VAL A 255ALA A 256GLY A 150SER A 145 | None | 1.33A | 4mmfB-1xhlA:undetectable | 4mmfB-1xhlA:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xje | RIBONUCLEOTIDEREDUCTASE,B12-DEPENDENT (Thermotogamaritima) |
PF00317(Ribonuc_red_lgN)PF02867(Ribonuc_red_lgC) | 5 | ALA A 617TYR A 614GLY A 246PHE A 247GLY A 624 | None | 1.15A | 4mmfB-1xjeA:undetectable | 4mmfB-1xjeA:23.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xkq | SHORT-CHAINREDUCTASE FAMILYMEMBER (5D234) (Caenorhabditiselegans) |
PF13561(adh_short_C2) | 5 | ASP A 170VAL A 257ALA A 258GLY A 152SER A 147 | None | 1.31A | 4mmfB-1xkqA:undetectable | 4mmfB-1xkqA:20.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zrz | PROTEIN KINASE C,IOTA (Homo sapiens) |
PF00069(Pkinase)PF00433(Pkinase_C) | 5 | VAL A 262ALA A 272TYR A 271GLY A 241SER A 311 | NoneBI1 A1000 (-3.4A)NoneNoneNone | 1.21A | 4mmfB-1zrzA:undetectable | 4mmfB-1zrzA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2aj4 | GALACTOKINASE (Saccharomycescerevisiae) |
PF00288(GHMP_kinases_N)PF08544(GHMP_kinases_C)PF10509(GalKase_gal_bdg) | 5 | ASP A 217VAL A 232ALA A 240GLY A 214PHE A 234 | GLA A 529 (-2.9A)NoneNoneGLA A 529 (-3.9A)None | 1.20A | 4mmfB-2aj4A:3.2 | 4mmfB-2aj4A:21.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cdp | BETA-AGARASE 1 (Saccharophagusdegradans) |
PF03422(CBM_6) | 5 | TYR A 63VAL A 108PHE A 76SER A 62GLY A 105 | None CL A1144 ( 4.2A)NoneNoneEDO A1141 (-4.0A) | 1.01A | 4mmfB-2cdpA:undetectable | 4mmfB-2cdpA:14.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cy8 | D-PHENYLGLYCINEAMINOTRANSFERASE (Pseudomonasstutzeri) |
PF00202(Aminotran_3) | 5 | ASP A 201ALA A 231GLY A 138SER A 200GLY A 235 | None | 1.15A | 4mmfB-2cy8A:undetectable | 4mmfB-2cy8A:22.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dne | DIHYDROLIPOYLLYSINE-RESIDUEACETYLTRANSFERASECOMPONENT OFPYRUVATEDEHYDROGENASECOMPLEX (Homo sapiens) |
PF00364(Biotin_lipoyl) | 5 | ASP A 72VAL A 66ALA A 67GLY A 22GLY A 69 | None | 1.25A | 4mmfB-2dneA:undetectable | 4mmfB-2dneA:11.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e3j | EPOXIDE HYDROLASEEPHB (Mycobacteriumtuberculosis) |
PF00561(Abhydrolase_1) | 5 | ASP A 20VAL A 30GLY A 52SER A 21GLY A 27 | NoneNoneNoneNoneACT A2006 ( 4.8A) | 1.40A | 4mmfB-2e3jA:undetectable | 4mmfB-2e3jA:23.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2epj | GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE (Aeropyrumpernix) |
PF00202(Aminotran_3) | 5 | VAL A 268ALA A 281GLY A 150SER A 120GLY A 270 | NoneNonePMP A 501 ( 3.9A)PMP A 501 ( 3.8A)None | 1.26A | 4mmfB-2epjA:undetectable | 4mmfB-2epjA:24.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hau | SEROTRANSFERRIN (Homo sapiens) |
PF00405(Transferrin) | 5 | VAL A 202ALA A 203GLY A 114SER A 157GLY A 200 | None | 1.22A | 4mmfB-2hauA:undetectable | 4mmfB-2hauA:20.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o6l | UDP-GLUCURONOSYLTRANSFERASE 2B7 (Homo sapiens) |
PF00201(UDPGT) | 5 | ASP A 435VAL A 413ALA A 412SER A 437GLY A 410 | None | 1.29A | 4mmfB-2o6lA:undetectable | 4mmfB-2o6lA:14.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2por | PORIN (Rhodobactercapsulatus) |
PF13609(Porin_4) | 5 | ASP A 93VAL A 292ALA A 293GLY A 99GLY A 280 | CA A 303 (-2.1A)NoneC8E A 546 ( 4.2A)NoneC8E A 546 (-3.9A) | 1.36A | 4mmfB-2porA:undetectable | 4mmfB-2porA:22.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aje | PUTATIVEUNCHARACTERIZEDPROTEIN ST1526 (Sulfurisphaeratokodaii) |
PF01300(Sua5_yciO_yrdC)PF03481(SUA5) | 5 | VAL A 294ALA A 295GLY A 317PHE A 318GLY A 324 | None | 1.00A | 4mmfB-3ajeA:undetectable | 4mmfB-3ajeA:22.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bvh | FIBRINOGEN BETACHAIN (Homo sapiens) |
PF00147(Fibrinogen_C)PF08702(Fib_alpha) | 5 | ASP B 241VAL B 238TYR B 239GLY B 248SER B 222 | None | 1.22A | 4mmfB-3bvhB:undetectable | 4mmfB-3bvhB:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ctd | PUTATIVE ATPASE, AAAFAMILY (Prochlorococcusmarinus) |
PF12002(MgsA_C)PF16193(AAA_assoc_2) | 6 | ASP A 311VAL A 318ALA A 340TYR A 343GLY A 308SER A 347 | None | 1.45A | 4mmfB-3ctdA:1.4 | 4mmfB-3ctdA:17.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dnf | 4-HYDROXY-3-METHYLBUT-2-ENYL DIPHOSPHATEREDUCTASE (Aquifexaeolicus) |
PF02401(LYTB) | 5 | VAL A 20ALA A 19GLY A 11PHE A 12GLY A 15 | NoneNoneNoneNoneF3S A2302 (-3.4A) | 1.28A | 4mmfB-3dnfA:undetectable | 4mmfB-3dnfA:20.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ed4 | ARYLSULFATASE (Escherichiacoli) |
PF00884(Sulfatase) | 5 | VAL A 192ALA A 246GLY A 272PHE A 270SER A 243 | None | 1.23A | 4mmfB-3ed4A:undetectable | 4mmfB-3ed4A:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ege | PUTATIVEMETHYLTRANSFERASEFROM ANTIBIOTICBIOSYNTHESIS PATHWAY (Trichormusvariabilis) |
PF08241(Methyltransf_11) | 5 | VAL A 58ALA A 38TYR A 59GLY A 34GLY A 96 | None | 1.32A | 4mmfB-3egeA:undetectable | 4mmfB-3egeA:19.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3enq | RIBOSE-5-PHOSPHATEISOMERASE A (Vibriovulnificus) |
PF06026(Rib_5-P_isom_A) | 5 | ASP A 170TYR A 172GLY A 96PHE A 129GLY A 127 | None | 1.38A | 4mmfB-3enqA:undetectable | 4mmfB-3enqA:19.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f8r | THIOREDOXINREDUCTASE (TRXB-3) (Sulfolobussolfataricus) |
PF07992(Pyr_redox_2) | 5 | ASP A 164VAL A 199TYR A 195GLY A 162GLY A 169 | NAP A4001 (-4.2A)NoneNAP A4001 (-4.5A)NAP A4001 ( 4.6A)None | 1.34A | 4mmfB-3f8rA:undetectable | 4mmfB-3f8rA:19.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fou | QUINOL-CYTOCHROME CREDUCTASE, RIESKEIRON-SULFUR SUBUNIT (Thermusthermophilus) |
PF00355(Rieske) | 5 | VAL A 126ALA A 121GLY A 78PHE A 108GLY A 124 | None | 1.39A | 4mmfB-3fouA:undetectable | 4mmfB-3fouA:15.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fys | PROTEIN DEGV (Bacillussubtilis) |
PF02645(DegV) | 5 | ASP A 218VAL A 254TYR A 251SER A 222GLY A 224 | None | 1.37A | 4mmfB-3fysA:undetectable | 4mmfB-3fysA:22.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g1b | ATP-DEPENDENT CLPPROTEASE ADAPTERPROTEIN CLPS (Caulobactervibrioides) |
PF02617(ClpS) | 5 | TYR A 89VAL A 101ALA A 99GLY A 87PHE A 64 | None | 1.36A | 4mmfB-3g1bA:undetectable | 4mmfB-3g1bA:7.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g23 | LD-CARBOXYPEPTIDASEA (Novosphingobiumaromaticivorans) |
PF02016(Peptidase_S66) | 5 | VAL A 164ALA A 163GLY A 107PHE A 166SER A 121 | None | 1.32A | 4mmfB-3g23A:undetectable | 4mmfB-3g23A:19.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3grh | ACYL-COA THIOESTERHYDROLASE YBGC (Escherichiacoli) |
PF01095(Pectinesterase) | 5 | ASP A 257VAL A 203ALA A 204GLY A 261PHE A 227 | None | 1.21A | 4mmfB-3grhA:undetectable | 4mmfB-3grhA:22.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gwf | CYCLOHEXANONEMONOOXYGENASE (Rhodococcus sp.HI-31) |
PF00743(FMO-like) | 5 | ASP A 59VAL A 246ALA A 247GLY A 277GLY A 249 | NAP A 542 ( 3.0A)NoneNoneNoneNone | 1.37A | 4mmfB-3gwfA:undetectable | 4mmfB-3gwfA:23.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h0g | DNA-DIRECTED RNAPOLYMERASE IISUBUNIT RPB2DNA-DIRECTED RNAPOLYMERASE IISUBUNIT RPB3 (Schizosaccharomycespombe) |
PF00562(RNA_pol_Rpb2_6)PF01000(RNA_pol_A_bac)PF01193(RNA_pol_L)PF04560(RNA_pol_Rpb2_7)PF04561(RNA_pol_Rpb2_2)PF04563(RNA_pol_Rpb2_1)PF04565(RNA_pol_Rpb2_3)PF04566(RNA_pol_Rpb2_4)PF04567(RNA_pol_Rpb2_5) | 5 | VAL C 177ALA C 178GLY B1064PHE B 990GLY B 994 | None | 1.36A | 4mmfB-3h0gC:undetectable | 4mmfB-3h0gC:19.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hgq | HDA1 COMPLEX SUBUNIT3 (Saccharomycescerevisiae) |
PF11496(HDA2-3) | 5 | ASP A 245VAL A 266ALA A 269GLY A 81SER A 243 | None | 1.26A | 4mmfB-3hgqA:undetectable | 4mmfB-3hgqA:21.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iy0 | FAB 14, HEAVY DOMAIN (Mus musculus) |
PF07686(V-set) | 5 | VAL H 12ALA H 13GLY H 92SER H 88GLY H 119 | None | 1.37A | 4mmfB-3iy0H:undetectable | 4mmfB-3iy0H:13.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ke3 | PUTATIVESERINE-PYRUVATEAMINOTRANSFERASE (Psychrobacterarcticus) |
PF00266(Aminotran_5) | 5 | VAL A 298ALA A 299GLY A 334SER A 146GLY A 148 | None | 1.24A | 4mmfB-3ke3A:undetectable | 4mmfB-3ke3A:21.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mc2 | INHIBITOR OFCARBONIC ANHYDRASE (Mus musculus) |
PF00405(Transferrin) | 5 | VAL A 533ALA A 534GLY A 447SER A 484GLY A 531 | None | 1.27A | 4mmfB-3mc2A:undetectable | 4mmfB-3mc2A:20.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mdn | GLUTAMINEAMINOTRANSFERASECLASS-II DOMAINPROTEIN (Ruegeriapomeroyi) |
PF13230(GATase_4) | 5 | ASP A 50VAL A 73ALA A 74GLY A 56SER A 79 | None | 1.22A | 4mmfB-3mdnA:undetectable | 4mmfB-3mdnA:18.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mpl | VIRULENCE SENSORPROTEIN BVGS (Bordetellapertussis) |
PF00497(SBP_bac_3) | 5 | VAL A 311ALA A 312GLY A 330PHE A 329GLY A 352 | None | 1.25A | 4mmfB-3mplA:undetectable | 4mmfB-3mplA:18.98 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3mpn | TRANSPORTER (Aquifexaeolicus) |
PF00209(SNF) | 5 | VAL A 104ALA A 105TYR A 108PHE A 259SER A 355 | NoneNoneLEU A 601 (-4.5A)LEU A 601 (-3.6A) NA A 751 ( 2.3A) | 0.36A | 4mmfB-3mpnA:60.8 | 4mmfB-3mpnA:98.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pzu | ENDOGLUCANASE (Bacillussubtilis) |
PF00150(Cellulase) | 5 | VAL A 57ALA A 56GLY A 40SER A 43GLY A 54 | None | 1.39A | 4mmfB-3pzuA:undetectable | 4mmfB-3pzuA:21.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q75 | FARNESYLTRANSFERASEBETA SUBUNIT (Cryptococcusneoformans) |
PF00432(Prenyltrans) | 5 | ASP B 42VAL B 386ALA B 387SER B 38GLY B 311 | None | 1.35A | 4mmfB-3q75B:undetectable | 4mmfB-3q75B:20.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rwb | PYRIDOXAL4-DEHYDROGENASE (Mesorhizobiumloti) |
PF13561(adh_short_C2) | 5 | ALA A 157TYR A 154GLY A 147SER A 141GLY A 159 | NoneNAD A 251 ( 4.5A)None4PL A 252 (-2.7A)None | 1.13A | 4mmfB-3rwbA:undetectable | 4mmfB-3rwbA:19.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sho | TRANSCRIPTIONALREGULATOR, RPIRFAMILY (Sphaerobacterthermophilus) |
PF01380(SIS) | 5 | VAL A 148ALA A 149PHE A 144SER A 190GLY A 141 | None | 1.28A | 4mmfB-3shoA:undetectable | 4mmfB-3shoA:19.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sjn | MANDELATERACEMASE/MUCONATELACTONIZING PROTEIN (Shewanellapealeana) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ASP A 178VAL A 185ALA A 184GLY A 167PHE A 166 | None | 1.30A | 4mmfB-3sjnA:undetectable | 4mmfB-3sjnA:20.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tv2 | FUMARATE HYDRATASE,CLASS II (Burkholderiapseudomallei) |
PF00206(Lyase_1)PF10415(FumaraseC_C) | 5 | ASP A 282VAL A 386ALA A 384GLY A 277PHE A 382 | None | 1.27A | 4mmfB-3tv2A:0.8 | 4mmfB-3tv2A:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tv2 | FUMARATE HYDRATASE,CLASS II (Burkholderiapseudomallei) |
PF00206(Lyase_1)PF10415(FumaraseC_C) | 5 | ASP A 282VAL A 386ALA A 387GLY A 277PHE A 382 | None | 1.35A | 4mmfB-3tv2A:0.8 | 4mmfB-3tv2A:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wbk | EUKARYOTICTRANSLATIONINITIATION FACTOR 5B (Saccharomycescerevisiae) |
PF00009(GTP_EFTU)PF03144(GTP_EFTU_D2)PF11987(IF-2) | 5 | ASP A 412ALA A 367GLY A 79SER A 360GLY A 363 | None | 1.13A | 4mmfB-3wbkA:undetectable | 4mmfB-3wbkA:23.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wo8 | BETA-N-ACETYLGLUCOSAMINIDASE (Thermotogamaritima) |
PF00933(Glyco_hydro_3) | 5 | TYR A 95VAL A 111GLY A 66SER A 96GLY A 100 | None | 1.08A | 4mmfB-3wo8A:undetectable | 4mmfB-3wo8A:23.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wyw | GLUTATHIONES-TRANSFERASE (Nilaparvatalugens) |
PF00043(GST_C)PF13417(GST_N_3) | 5 | TYR A 107VAL A 171ALA A 170GLY A 111SER A 164 | None | 1.18A | 4mmfB-3wywA:undetectable | 4mmfB-3wywA:18.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zuk | ENDOPEPTIDASE,PEPTIDASE FAMILY M13 (Mycobacteriumtuberculosis) |
PF01431(Peptidase_M13)PF05649(Peptidase_M13_N) | 5 | VAL A 596ALA A 482TYR A 484GLY A 567GLY A 486 | None | 1.16A | 4mmfB-3zukA:undetectable | 4mmfB-3zukA:21.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4au0 | EXOGLUCANASE 2 (Trichodermareesei) |
PF01341(Glyco_hydro_6) | 5 | VAL A 127ALA A 126GLY A 374PHE A 375SER A 445 | None | 1.24A | 4mmfB-4au0A:undetectable | 4mmfB-4au0A:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ezb | UNCHARACTERIZEDCONSERVED PROTEIN (Sinorhizobiummeliloti) |
PF03807(F420_oxidored)PF09130(DUF1932) | 5 | ASP A 96ALA A 13GLY A 74SER A 70GLY A 8 | None | 1.17A | 4mmfB-4ezbA:undetectable | 4mmfB-4ezbA:22.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fbo | PSEUDOMONASFLUORESCENSAGGLUTININ (Pseudomonasfluorescens) |
no annotation | 5 | VAL A 6ALA A 5TYR A 4GLY A 116PHE A 128 | None | 1.35A | 4mmfB-4fboA:undetectable | 4mmfB-4fboA:15.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g4e | ATP-DEPENDENTPROTEASE SUBUNITHSLV (Escherichiacoli) |
PF00227(Proteasome) | 5 | VAL A 4ALA A 121GLY A 156SER A 124GLY A 126 | None | 1.27A | 4mmfB-4g4eA:undetectable | 4mmfB-4g4eA:15.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gk9 | AGGLUTININ (BOA) (Burkholderiaoklahomensis) |
no annotation | 5 | VAL A 81ALA A 80TYR A 79GLY A 57PHE A 69 | None | 1.35A | 4mmfB-4gk9A:undetectable | 4mmfB-4gk9A:19.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gk9 | AGGLUTININ (BOA) (Burkholderiaoklahomensis) |
no annotation | 5 | VAL A 148ALA A 147TYR A 146GLY A 257PHE A 269 | None | 1.34A | 4mmfB-4gk9A:undetectable | 4mmfB-4gk9A:19.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gk9 | AGGLUTININ (BOA) (Burkholderiaoklahomensis) |
no annotation | 5 | VAL A 214ALA A 213TYR A 212GLY A 190PHE A 202 | None | 1.34A | 4mmfB-4gk9A:undetectable | 4mmfB-4gk9A:19.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kh3 | ANTIGEN 43 (Escherichiacoli) |
PF16168(AIDA) | 5 | ASP A 339VAL A 344GLY A 322SER A 340GLY A 357 | None | 1.24A | 4mmfB-4kh3A:undetectable | 4mmfB-4kh3A:22.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lc9 | GLUCOKINASEREGULATORY PROTEIN (Rattusnorvegicus) |
no annotation | 5 | ASP A 142ALA A 114TYR A 136GLY A 140GLY A 111 | None | 1.14A | 4mmfB-4lc9A:undetectable | 4mmfB-4lc9A:22.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nml | RIBULOSE 5-PHOSPHATEISOMERASE (Toxoplasmagondii) |
PF06026(Rib_5-P_isom_A) | 5 | ASP A 91ALA A 239GLY A 233PHE A 235GLY A 99 | MLT A 303 (-4.5A)NoneNoneNoneNone | 1.17A | 4mmfB-4nmlA:undetectable | 4mmfB-4nmlA:20.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ohn | ABC TRANSPORTERSUBSTRATE-BINDINGPROTEIN (Streptococcuspneumoniae) |
PF00497(SBP_bac_3) | 5 | ALA A 62TYR A 61GLY A 44SER A 47GLY A 53 | None | 1.03A | 4mmfB-4ohnA:undetectable | 4mmfB-4ohnA:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pag | PERIPLASMIC BINDINGPROTEIN (Sulfurospirillumdeleyianum) |
PF01497(Peripla_BP_2) | 5 | ASP A 286ALA A 192TYR A 191GLY A 229GLY A 194 | None | 1.33A | 4mmfB-4pagA:1.3 | 4mmfB-4pagA:21.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4psp | ALPHA-FUCOSIDASEGH29 (Fusariumgraminearum) |
PF01120(Alpha_L_fucos)PF16757(Fucosidase_C) | 5 | ASP A 303VAL A 167ALA A 120TYR A 32GLY A 30 | GOL A 622 (-2.6A)NoneNoneNoneNone | 1.01A | 4mmfB-4pspA:undetectable | 4mmfB-4pspA:23.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q0c | VIRULENCE SENSORPROTEIN BVGS (Bordetellapertussis) |
PF00497(SBP_bac_3) | 5 | VAL A 311ALA A 312GLY A 330PHE A 329GLY A 352 | None | 1.21A | 4mmfB-4q0cA:undetectable | 4mmfB-4q0cA:22.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qav | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 2 (Neisseriameningitidis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | VAL A 351ALA A 350TYR A 352GLY A 236GLY A 346 | None | 1.22A | 4mmfB-4qavA:undetectable | 4mmfB-4qavA:23.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qax | 2,3-BISPHOSPHOGLYCERATE-INDEPENDENTPHOSPHOGLYCERATEMUTASE (Staphylococcusaureus) |
PF01676(Metalloenzyme)PF06415(iPGM_N) | 5 | ASP A 230ALA A 222TYR A 224GLY A 184GLY A 219 | None | 1.18A | 4mmfB-4qaxA:undetectable | 4mmfB-4qaxA:23.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qiu | NITRONATEMONOOXYGENASE FAMILYPROTEIN (Pseudomonasaeruginosa) |
PF03060(NMO) | 5 | VAL A 32ALA A 31GLY A 239PHE A 242SER A 24 | NoneNoneFMN A 401 (-3.3A)NoneNone | 1.09A | 4mmfB-4qiuA:undetectable | 4mmfB-4qiuA:24.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rjw | PORIN O (Pseudomonasaeruginosa) |
PF07396(Porin_O_P) | 5 | ASP A 116VAL A 189ALA A 162TYR A 163SER A 165 | None | 1.33A | 4mmfB-4rjwA:undetectable | 4mmfB-4rjwA:21.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uoo | LIPOTEICHOIC ACIDSYNTHASE (Listeriamonocytogenes) |
PF00884(Sulfatase) | 5 | TYR A 380VAL A 351ALA A 350GLY A 354SER A 401 | None | 1.24A | 4mmfB-4uooA:undetectable | 4mmfB-4uooA:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4usq | PYRIDINENUCLEOTIDE-DISULFIDEOXIDOREDUCTASE (Cellvibrio sp.BR) |
PF13738(Pyr_redox_3) | 5 | VAL A 286ALA A 285GLY A 150PHE A 268GLY A 156 | None | 1.26A | 4mmfB-4usqA:undetectable | 4mmfB-4usqA:21.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xnu | INTEGRAL MEMBRANEPROTEIN-DOPAMINETRANSPORTER (Drosophilamelanogaster) |
PF00209(SNF) | 5 | ASP A 46TYR A 124GLY A 322SER A 421GLY A 424 | 41U A 605 ( 3.3A)41U A 605 ( 3.8A)41U A 605 ( 4.1A) NA A 602 ( 2.4A)None | 1.03A | 4mmfB-4xnuA:40.7 | 4mmfB-4xnuA:29.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xnu | INTEGRAL MEMBRANEPROTEIN-DOPAMINETRANSPORTER (Drosophilamelanogaster) |
PF00209(SNF) | 6 | ASP A 46VAL A 120TYR A 124GLY A 322SER A 421GLY A 425 | 41U A 605 ( 3.3A)41U A 605 (-4.2A)41U A 605 ( 3.8A)41U A 605 ( 4.1A) NA A 602 ( 2.4A)41U A 605 ( 3.7A) | 0.66A | 4mmfB-4xnuA:40.7 | 4mmfB-4xnuA:29.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5aa6 | VANADIUM-DEPENDENTBROMOPEROXIDASE 2 (Ascophyllumnodosum) |
no annotation | 5 | ASP A 155VAL A 73ALA A 72GLY A 153GLY A 69 | None | 1.32A | 4mmfB-5aa6A:undetectable | 4mmfB-5aa6A:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b3h | PROTEIN SCARECROW (Arabidopsisthaliana) |
PF03514(GRAS) | 5 | VAL A 517ALA A 648GLY A 599PHE A 600GLY A 602 | None | 1.20A | 4mmfB-5b3hA:undetectable | 4mmfB-5b3hA:22.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ce6 | FACT-SPT16 (Cicer arietinum) |
PF00557(Peptidase_M24)PF14826(FACT-Spt16_Nlob) | 5 | VAL A 55ALA A 54GLY A 189PHE A 190GLY A 157 | None | 1.30A | 4mmfB-5ce6A:undetectable | 4mmfB-5ce6A:23.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ee7 | GLUCAGONRECEPTOR,ENDOLYSIN,GLUCAGON RECEPTOR (Escherichiavirus T4;Homo sapiens) |
PF00002(7tm_2)PF00959(Phage_lysozyme) | 5 | ALA A 237TYR A 239GLY A 393PHE A 184GLY A 234 | NonePE5 A1216 (-4.7A)NoneNoneNone | 1.40A | 4mmfB-5ee7A:undetectable | 4mmfB-5ee7A:23.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5epg | ALDEHYDE OXIDASE (Homo sapiens) |
PF00111(Fer2)PF00941(FAD_binding_5)PF01315(Ald_Xan_dh_C)PF01799(Fer2_2)PF02738(Ald_Xan_dh_C2)PF03450(CO_deh_flav_C) | 5 | ASP A1093VAL A1163TYR A1161SER A1265GLY A1192 | None | 1.03A | 4mmfB-5epgA:1.0 | 4mmfB-5epgA:18.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ham | RICKCE (Rickettsiabellii) |
no annotation | 5 | ASP A 624GLY A 656PHE A 631SER A 626GLY A 629 | None | 1.01A | 4mmfB-5hamA:undetectable | 4mmfB-5hamA:20.42 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5i6z | SODIUM-DEPENDENTSEROTONINTRANSPORTER (Homo sapiens) |
PF00209(SNF) | 6 | TYR A 95ASP A 98ALA A 173TYR A 176GLY A 338SER A 438 | None | 0.82A | 4mmfB-5i6zA:42.0 | 4mmfB-5i6zA:30.92 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5i6z | SODIUM-DEPENDENTSEROTONINTRANSPORTER (Homo sapiens) |
PF00209(SNF) | 6 | TYR A 95ASP A 98TYR A 176GLY A 338SER A 438GLY A 442 | None | 0.66A | 4mmfB-5i6zA:42.0 | 4mmfB-5i6zA:30.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mqp | GLYCOSIDE HYDROLASEBT_1002 (Bacteroidesthetaiotaomicron) |
no annotation | 5 | VAL A 524ALA A 525TYR A 528GLY A 464GLY A 490 | None | 1.32A | 4mmfB-5mqpA:undetectable | 4mmfB-5mqpA:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o5c | PUTATIVEDECARBOXYLASEINVOLVED INDESFERRIOXAMINEBIOSYNTHESIS (Erwiniaamylovora) |
no annotation | 5 | VAL A 466ALA A 465PHE A 460SER A 58GLY A 463 | None | 1.33A | 4mmfB-5o5cA:undetectable | 4mmfB-5o5cA:9.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wab | PUTATIVEBETA-GLUCOSIDASE (Bifidobacteriumadolescentis) |
no annotation | 5 | VAL A 102ALA A 103GLY A 45SER A 151GLY A 149 | None | 1.27A | 4mmfB-5wabA:undetectable | 4mmfB-5wabA:13.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zby | HYDROGENASEMATURATION PROTEASEHYCI (Thermococcuskodakarensis) |
no annotation | 5 | VAL A 33ALA A 34GLY A 124PHE A 29GLY A 18 | None | 0.96A | 4mmfB-5zbyA:undetectable | 4mmfB-5zbyA:11.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6en9 | HYDROGENASE-2 SMALLCHAIN (Escherichiacoli) |
no annotation | 5 | VAL S 126ALA S 127GLY S 153SER S 121GLY S 124 | None | 1.37A | 4mmfB-6en9S:undetectable | 4mmfB-6en9S:9.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6en9 | HYDROGENASE-2 SMALLCHAIN (Escherichiacoli) |
no annotation | 5 | VAL S 126ALA S 128GLY S 153SER S 121GLY S 124 | None | 1.39A | 4mmfB-6en9S:undetectable | 4mmfB-6en9S:9.65 |