SIMILAR PATTERNS OF AMINO ACIDS FOR 4MMF_B_29QB603_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bev BOVINE ENTEROVIRUS
COAT PROTEINS VP1 TO
VP4


(Enterovirus E)
PF00073
(Rhv)
5 ALA 1 254
GLY 3  63
PHE 2 156
SER 1 268
GLY 1 266
None
0.98A 4mmfB-1bev1:
undetectable
4mmfB-1bev1:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cen CELLULASE CELC

(Ruminiclostridium
thermocellum)
PF00150
(Cellulase)
5 ASP A  43
VAL A  86
ALA A 134
GLY A 309
SER A   3
None
1.24A 4mmfB-1cenA:
undetectable
4mmfB-1cenA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbi AK.1 SERINE PROTEASE

(Bacillus sp.
Ak1)
PF00082
(Peptidase_S8)
5 ASP A  48
VAL A 211
ALA A 220
TYR A 219
GLY A  92
CA  A 701 (-2.2A)
None
None
None
None
1.02A 4mmfB-1dbiA:
undetectable
4mmfB-1dbiA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dot DUCK OVOTRANSFERRIN

(Anas
platyrhynchos)
PF00405
(Transferrin)
5 VAL A 399
ALA A 402
GLY A 412
PHE A 656
SER A 393
None
1.38A 4mmfB-1dotA:
0.0
4mmfB-1dotA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3j NADP(H)-DEPENDENT
KETOSE REDUCTASE


(Bemisia
argentifolii)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 VAL A 219
ALA A 199
GLY A 257
SER A 248
GLY A 176
None
PO4  A 903 (-3.4A)
None
None
PO4  A 903 ( 3.9A)
1.20A 4mmfB-1e3jA:
0.0
4mmfB-1e3jA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fi8 ECOTIN
NATURAL KILLER CELL
PROTEASE 1


(Escherichia
coli;
Rattus
norvegicus)
PF00089
(Trypsin)
PF03974
(Ecotin)
5 ASP C  84
VAL A 138
GLY A 142
SER A 195
GLY A 197
None
1.14A 4mmfB-1fi8C:
undetectable
4mmfB-1fi8C:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h76 SEROTRANSFERRIN

(Sus scrofa)
PF00405
(Transferrin)
5 VAL A 206
ALA A 207
GLY A 113
SER A 156
GLY A 204
None
1.22A 4mmfB-1h76A:
0.0
4mmfB-1h76A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hzf COMPLEMENT FACTOR
C4A


(Homo sapiens)
PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl)
5 ALA A1005
TYR A1008
GLY A1274
PHE A1280
SER A 977
None
0.87A 4mmfB-1hzfA:
1.5
4mmfB-1hzfA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i36 CONSERVED
HYPOTHETICAL PROTEIN
MTH1747


(Methanothermobacter
thermautotrophicus)
PF03807
(F420_oxidored)
PF09130
(DUF1932)
5 ASP A  86
VAL A  11
ALA A  12
SER A  62
GLY A   7
None
NAP  A1350 (-3.8A)
None
None
NAP  A1350 (-3.4A)
1.13A 4mmfB-1i36A:
undetectable
4mmfB-1i36A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jkm BREFELDIN A ESTERASE

(Bacillus
subtilis)
PF07859
(Abhydrolase_3)
5 VAL A 269
ALA A 266
TYR A 238
GLY A 127
GLY A 264
None
1.35A 4mmfB-1jkmA:
0.0
4mmfB-1jkmA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1j FIBRINOGEN BETA
CHAIN


(Gallus gallus)
PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha)
5 ASP B 246
VAL B 243
TYR B 244
GLY B 253
SER B 227
None
1.23A 4mmfB-1m1jB:
undetectable
4mmfB-1m1jB:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mn6 POLYKETIDE SYNTHASE
IV


(Streptomyces
venezuelae)
PF00975
(Thioesterase)
5 ASP A 207
VAL A  31
ALA A  33
PHE A  28
GLY A 214
None
1.17A 4mmfB-1mn6A:
0.0
4mmfB-1mn6A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n76 LACTOFERRIN

(Homo sapiens)
PF00405
(Transferrin)
5 VAL A 542
ALA A 543
GLY A 455
SER A 492
GLY A 540
None
1.21A 4mmfB-1n76A:
undetectable
4mmfB-1n76A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s4e GALACTOKINASE

(Pyrococcus
furiosus)
PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg)
5 VAL A 155
ALA A 154
GLY A 351
SER A 347
GLY A 158
None
1.30A 4mmfB-1s4eA:
undetectable
4mmfB-1s4eA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tki TITIN

(Homo sapiens)
PF00069
(Pkinase)
5 ASP A 144
VAL A 191
ALA A 188
TYR A 187
GLY A 141
None
1.30A 4mmfB-1tkiA:
undetectable
4mmfB-1tkiA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u9c APC35852

(Geobacillus
stearothermophilus)
PF01965
(DJ-1_PfpI)
5 VAL A 192
GLY A 184
PHE A 190
SER A 151
GLY A 200
None
1.17A 4mmfB-1u9cA:
undetectable
4mmfB-1u9cA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vdk FUMARATE HYDRATASE
CLASS II


(Thermus
thermophilus)
PF00206
(Lyase_1)
PF10415
(FumaraseC_C)
5 ASP A 142
VAL A 246
ALA A 247
GLY A 137
PHE A 242
None
1.19A 4mmfB-1vdkA:
1.0
4mmfB-1vdkA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w0m TRIOSEPHOSPHATE
ISOMERASE


(Thermoproteus
tenax)
PF00121
(TIM)
PF05690
(ThiG)
5 VAL A  89
ALA A  61
TYR A  60
GLY A 114
GLY A  86
None
1.21A 4mmfB-1w0mA:
undetectable
4mmfB-1w0mA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xhl SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY MEMBER
(5L265), PUTATIVE
TROPINONE
REDUCTASE-II


(Caenorhabditis
elegans)
PF13561
(adh_short_C2)
5 ASP A 168
VAL A 255
ALA A 256
GLY A 150
SER A 145
None
1.33A 4mmfB-1xhlA:
undetectable
4mmfB-1xhlA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT


(Thermotoga
maritima)
PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
5 ALA A 617
TYR A 614
GLY A 246
PHE A 247
GLY A 624
None
1.15A 4mmfB-1xjeA:
undetectable
4mmfB-1xjeA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkq SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5D234)


(Caenorhabditis
elegans)
PF13561
(adh_short_C2)
5 ASP A 170
VAL A 257
ALA A 258
GLY A 152
SER A 147
None
1.31A 4mmfB-1xkqA:
undetectable
4mmfB-1xkqA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zrz PROTEIN KINASE C,
IOTA


(Homo sapiens)
PF00069
(Pkinase)
PF00433
(Pkinase_C)
5 VAL A 262
ALA A 272
TYR A 271
GLY A 241
SER A 311
None
BI1  A1000 (-3.4A)
None
None
None
1.21A 4mmfB-1zrzA:
undetectable
4mmfB-1zrzA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aj4 GALACTOKINASE

(Saccharomyces
cerevisiae)
PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg)
5 ASP A 217
VAL A 232
ALA A 240
GLY A 214
PHE A 234
GLA  A 529 (-2.9A)
None
None
GLA  A 529 (-3.9A)
None
1.20A 4mmfB-2aj4A:
3.2
4mmfB-2aj4A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cdp BETA-AGARASE 1

(Saccharophagus
degradans)
PF03422
(CBM_6)
5 TYR A  63
VAL A 108
PHE A  76
SER A  62
GLY A 105
None
CL  A1144 ( 4.2A)
None
None
EDO  A1141 (-4.0A)
1.01A 4mmfB-2cdpA:
undetectable
4mmfB-2cdpA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cy8 D-PHENYLGLYCINE
AMINOTRANSFERASE


(Pseudomonas
stutzeri)
PF00202
(Aminotran_3)
5 ASP A 201
ALA A 231
GLY A 138
SER A 200
GLY A 235
None
1.15A 4mmfB-2cy8A:
undetectable
4mmfB-2cy8A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dne DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE
COMPONENT OF
PYRUVATE
DEHYDROGENASE
COMPLEX


(Homo sapiens)
PF00364
(Biotin_lipoyl)
5 ASP A  72
VAL A  66
ALA A  67
GLY A  22
GLY A  69
None
1.25A 4mmfB-2dneA:
undetectable
4mmfB-2dneA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3j EPOXIDE HYDROLASE
EPHB


(Mycobacterium
tuberculosis)
PF00561
(Abhydrolase_1)
5 ASP A  20
VAL A  30
GLY A  52
SER A  21
GLY A  27
None
None
None
None
ACT  A2006 ( 4.8A)
1.40A 4mmfB-2e3jA:
undetectable
4mmfB-2e3jA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epj GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE


(Aeropyrum
pernix)
PF00202
(Aminotran_3)
5 VAL A 268
ALA A 281
GLY A 150
SER A 120
GLY A 270
None
None
PMP  A 501 ( 3.9A)
PMP  A 501 ( 3.8A)
None
1.26A 4mmfB-2epjA:
undetectable
4mmfB-2epjA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hau SEROTRANSFERRIN

(Homo sapiens)
PF00405
(Transferrin)
5 VAL A 202
ALA A 203
GLY A 114
SER A 157
GLY A 200
None
1.22A 4mmfB-2hauA:
undetectable
4mmfB-2hauA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6l UDP-GLUCURONOSYLTRAN
SFERASE 2B7


(Homo sapiens)
PF00201
(UDPGT)
5 ASP A 435
VAL A 413
ALA A 412
SER A 437
GLY A 410
None
1.29A 4mmfB-2o6lA:
undetectable
4mmfB-2o6lA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2por PORIN

(Rhodobacter
capsulatus)
PF13609
(Porin_4)
5 ASP A  93
VAL A 292
ALA A 293
GLY A  99
GLY A 280
CA  A 303 (-2.1A)
None
C8E  A 546 ( 4.2A)
None
C8E  A 546 (-3.9A)
1.36A 4mmfB-2porA:
undetectable
4mmfB-2porA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aje PUTATIVE
UNCHARACTERIZED
PROTEIN ST1526


(Sulfurisphaera
tokodaii)
PF01300
(Sua5_yciO_yrdC)
PF03481
(SUA5)
5 VAL A 294
ALA A 295
GLY A 317
PHE A 318
GLY A 324
None
1.00A 4mmfB-3ajeA:
undetectable
4mmfB-3ajeA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bvh FIBRINOGEN BETA
CHAIN


(Homo sapiens)
PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha)
5 ASP B 241
VAL B 238
TYR B 239
GLY B 248
SER B 222
None
1.22A 4mmfB-3bvhB:
undetectable
4mmfB-3bvhB:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctd PUTATIVE ATPASE, AAA
FAMILY


(Prochlorococcus
marinus)
PF12002
(MgsA_C)
PF16193
(AAA_assoc_2)
6 ASP A 311
VAL A 318
ALA A 340
TYR A 343
GLY A 308
SER A 347
None
1.45A 4mmfB-3ctdA:
1.4
4mmfB-3ctdA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dnf 4-HYDROXY-3-METHYLBU
T-2-ENYL DIPHOSPHATE
REDUCTASE


(Aquifex
aeolicus)
PF02401
(LYTB)
5 VAL A  20
ALA A  19
GLY A  11
PHE A  12
GLY A  15
None
None
None
None
F3S  A2302 (-3.4A)
1.28A 4mmfB-3dnfA:
undetectable
4mmfB-3dnfA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ed4 ARYLSULFATASE

(Escherichia
coli)
PF00884
(Sulfatase)
5 VAL A 192
ALA A 246
GLY A 272
PHE A 270
SER A 243
None
1.23A 4mmfB-3ed4A:
undetectable
4mmfB-3ed4A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ege PUTATIVE
METHYLTRANSFERASE
FROM ANTIBIOTIC
BIOSYNTHESIS PATHWAY


(Trichormus
variabilis)
PF08241
(Methyltransf_11)
5 VAL A  58
ALA A  38
TYR A  59
GLY A  34
GLY A  96
None
1.32A 4mmfB-3egeA:
undetectable
4mmfB-3egeA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3enq RIBOSE-5-PHOSPHATE
ISOMERASE A


(Vibrio
vulnificus)
PF06026
(Rib_5-P_isom_A)
5 ASP A 170
TYR A 172
GLY A  96
PHE A 129
GLY A 127
None
1.38A 4mmfB-3enqA:
undetectable
4mmfB-3enqA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f8r THIOREDOXIN
REDUCTASE (TRXB-3)


(Sulfolobus
solfataricus)
PF07992
(Pyr_redox_2)
5 ASP A 164
VAL A 199
TYR A 195
GLY A 162
GLY A 169
NAP  A4001 (-4.2A)
None
NAP  A4001 (-4.5A)
NAP  A4001 ( 4.6A)
None
1.34A 4mmfB-3f8rA:
undetectable
4mmfB-3f8rA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fou QUINOL-CYTOCHROME C
REDUCTASE, RIESKE
IRON-SULFUR SUBUNIT


(Thermus
thermophilus)
PF00355
(Rieske)
5 VAL A 126
ALA A 121
GLY A  78
PHE A 108
GLY A 124
None
1.39A 4mmfB-3fouA:
undetectable
4mmfB-3fouA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fys PROTEIN DEGV

(Bacillus
subtilis)
PF02645
(DegV)
5 ASP A 218
VAL A 254
TYR A 251
SER A 222
GLY A 224
None
1.37A 4mmfB-3fysA:
undetectable
4mmfB-3fysA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1b ATP-DEPENDENT CLP
PROTEASE ADAPTER
PROTEIN CLPS


(Caulobacter
vibrioides)
PF02617
(ClpS)
5 TYR A  89
VAL A 101
ALA A  99
GLY A  87
PHE A  64
None
1.36A 4mmfB-3g1bA:
undetectable
4mmfB-3g1bA:
7.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g23 LD-CARBOXYPEPTIDASE
A


(Novosphingobium
aromaticivorans)
PF02016
(Peptidase_S66)
5 VAL A 164
ALA A 163
GLY A 107
PHE A 166
SER A 121
None
1.32A 4mmfB-3g23A:
undetectable
4mmfB-3g23A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3grh ACYL-COA THIOESTER
HYDROLASE YBGC


(Escherichia
coli)
PF01095
(Pectinesterase)
5 ASP A 257
VAL A 203
ALA A 204
GLY A 261
PHE A 227
None
1.21A 4mmfB-3grhA:
undetectable
4mmfB-3grhA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwf CYCLOHEXANONE
MONOOXYGENASE


(Rhodococcus sp.
HI-31)
PF00743
(FMO-like)
5 ASP A  59
VAL A 246
ALA A 247
GLY A 277
GLY A 249
NAP  A 542 ( 3.0A)
None
None
None
None
1.37A 4mmfB-3gwfA:
undetectable
4mmfB-3gwfA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3


(Schizosaccharomyces
pombe)
PF00562
(RNA_pol_Rpb2_6)
PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
5 VAL C 177
ALA C 178
GLY B1064
PHE B 990
GLY B 994
None
1.36A 4mmfB-3h0gC:
undetectable
4mmfB-3h0gC:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hgq HDA1 COMPLEX SUBUNIT
3


(Saccharomyces
cerevisiae)
PF11496
(HDA2-3)
5 ASP A 245
VAL A 266
ALA A 269
GLY A  81
SER A 243
None
1.26A 4mmfB-3hgqA:
undetectable
4mmfB-3hgqA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iy0 FAB 14, HEAVY DOMAIN

(Mus musculus)
PF07686
(V-set)
5 VAL H  12
ALA H  13
GLY H  92
SER H  88
GLY H 119
None
1.37A 4mmfB-3iy0H:
undetectable
4mmfB-3iy0H:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ke3 PUTATIVE
SERINE-PYRUVATE
AMINOTRANSFERASE


(Psychrobacter
arcticus)
PF00266
(Aminotran_5)
5 VAL A 298
ALA A 299
GLY A 334
SER A 146
GLY A 148
None
1.24A 4mmfB-3ke3A:
undetectable
4mmfB-3ke3A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mc2 INHIBITOR OF
CARBONIC ANHYDRASE


(Mus musculus)
PF00405
(Transferrin)
5 VAL A 533
ALA A 534
GLY A 447
SER A 484
GLY A 531
None
1.27A 4mmfB-3mc2A:
undetectable
4mmfB-3mc2A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdn GLUTAMINE
AMINOTRANSFERASE
CLASS-II DOMAIN
PROTEIN


(Ruegeria
pomeroyi)
PF13230
(GATase_4)
5 ASP A  50
VAL A  73
ALA A  74
GLY A  56
SER A  79
None
1.22A 4mmfB-3mdnA:
undetectable
4mmfB-3mdnA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpl VIRULENCE SENSOR
PROTEIN BVGS


(Bordetella
pertussis)
PF00497
(SBP_bac_3)
5 VAL A 311
ALA A 312
GLY A 330
PHE A 329
GLY A 352
None
1.25A 4mmfB-3mplA:
undetectable
4mmfB-3mplA:
18.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mpn TRANSPORTER

(Aquifex
aeolicus)
PF00209
(SNF)
5 VAL A 104
ALA A 105
TYR A 108
PHE A 259
SER A 355
None
None
LEU  A 601 (-4.5A)
LEU  A 601 (-3.6A)
NA  A 751 ( 2.3A)
0.36A 4mmfB-3mpnA:
60.8
4mmfB-3mpnA:
98.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pzu ENDOGLUCANASE

(Bacillus
subtilis)
PF00150
(Cellulase)
5 VAL A  57
ALA A  56
GLY A  40
SER A  43
GLY A  54
None
1.39A 4mmfB-3pzuA:
undetectable
4mmfB-3pzuA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q75 FARNESYLTRANSFERASE
BETA SUBUNIT


(Cryptococcus
neoformans)
PF00432
(Prenyltrans)
5 ASP B  42
VAL B 386
ALA B 387
SER B  38
GLY B 311
None
1.35A 4mmfB-3q75B:
undetectable
4mmfB-3q75B:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwb PYRIDOXAL
4-DEHYDROGENASE


(Mesorhizobium
loti)
PF13561
(adh_short_C2)
5 ALA A 157
TYR A 154
GLY A 147
SER A 141
GLY A 159
None
NAD  A 251 ( 4.5A)
None
4PL  A 252 (-2.7A)
None
1.13A 4mmfB-3rwbA:
undetectable
4mmfB-3rwbA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sho TRANSCRIPTIONAL
REGULATOR, RPIR
FAMILY


(Sphaerobacter
thermophilus)
PF01380
(SIS)
5 VAL A 148
ALA A 149
PHE A 144
SER A 190
GLY A 141
None
1.28A 4mmfB-3shoA:
undetectable
4mmfB-3shoA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sjn MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN


(Shewanella
pealeana)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 ASP A 178
VAL A 185
ALA A 184
GLY A 167
PHE A 166
None
1.30A 4mmfB-3sjnA:
undetectable
4mmfB-3sjnA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tv2 FUMARATE HYDRATASE,
CLASS II


(Burkholderia
pseudomallei)
PF00206
(Lyase_1)
PF10415
(FumaraseC_C)
5 ASP A 282
VAL A 386
ALA A 384
GLY A 277
PHE A 382
None
1.27A 4mmfB-3tv2A:
0.8
4mmfB-3tv2A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tv2 FUMARATE HYDRATASE,
CLASS II


(Burkholderia
pseudomallei)
PF00206
(Lyase_1)
PF10415
(FumaraseC_C)
5 ASP A 282
VAL A 386
ALA A 387
GLY A 277
PHE A 382
None
1.35A 4mmfB-3tv2A:
0.8
4mmfB-3tv2A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbk EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B


(Saccharomyces
cerevisiae)
PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2)
5 ASP A 412
ALA A 367
GLY A  79
SER A 360
GLY A 363
None
1.13A 4mmfB-3wbkA:
undetectable
4mmfB-3wbkA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wo8 BETA-N-ACETYLGLUCOSA
MINIDASE


(Thermotoga
maritima)
PF00933
(Glyco_hydro_3)
5 TYR A  95
VAL A 111
GLY A  66
SER A  96
GLY A 100
None
1.08A 4mmfB-3wo8A:
undetectable
4mmfB-3wo8A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wyw GLUTATHIONE
S-TRANSFERASE


(Nilaparvata
lugens)
PF00043
(GST_C)
PF13417
(GST_N_3)
5 TYR A 107
VAL A 171
ALA A 170
GLY A 111
SER A 164
None
1.18A 4mmfB-3wywA:
undetectable
4mmfB-3wywA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13


(Mycobacterium
tuberculosis)
PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N)
5 VAL A 596
ALA A 482
TYR A 484
GLY A 567
GLY A 486
None
1.16A 4mmfB-3zukA:
undetectable
4mmfB-3zukA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4au0 EXOGLUCANASE 2

(Trichoderma
reesei)
PF01341
(Glyco_hydro_6)
5 VAL A 127
ALA A 126
GLY A 374
PHE A 375
SER A 445
None
1.24A 4mmfB-4au0A:
undetectable
4mmfB-4au0A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ezb UNCHARACTERIZED
CONSERVED PROTEIN


(Sinorhizobium
meliloti)
PF03807
(F420_oxidored)
PF09130
(DUF1932)
5 ASP A  96
ALA A  13
GLY A  74
SER A  70
GLY A   8
None
1.17A 4mmfB-4ezbA:
undetectable
4mmfB-4ezbA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fbo PSEUDOMONAS
FLUORESCENS
AGGLUTININ


(Pseudomonas
fluorescens)
no annotation 5 VAL A   6
ALA A   5
TYR A   4
GLY A 116
PHE A 128
None
1.35A 4mmfB-4fboA:
undetectable
4mmfB-4fboA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g4e ATP-DEPENDENT
PROTEASE SUBUNIT
HSLV


(Escherichia
coli)
PF00227
(Proteasome)
5 VAL A   4
ALA A 121
GLY A 156
SER A 124
GLY A 126
None
1.27A 4mmfB-4g4eA:
undetectable
4mmfB-4g4eA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gk9 AGGLUTININ (BOA)

(Burkholderia
oklahomensis)
no annotation 5 VAL A  81
ALA A  80
TYR A  79
GLY A  57
PHE A  69
None
1.35A 4mmfB-4gk9A:
undetectable
4mmfB-4gk9A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gk9 AGGLUTININ (BOA)

(Burkholderia
oklahomensis)
no annotation 5 VAL A 148
ALA A 147
TYR A 146
GLY A 257
PHE A 269
None
1.34A 4mmfB-4gk9A:
undetectable
4mmfB-4gk9A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gk9 AGGLUTININ (BOA)

(Burkholderia
oklahomensis)
no annotation 5 VAL A 214
ALA A 213
TYR A 212
GLY A 190
PHE A 202
None
1.34A 4mmfB-4gk9A:
undetectable
4mmfB-4gk9A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kh3 ANTIGEN 43

(Escherichia
coli)
PF16168
(AIDA)
5 ASP A 339
VAL A 344
GLY A 322
SER A 340
GLY A 357
None
1.24A 4mmfB-4kh3A:
undetectable
4mmfB-4kh3A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lc9 GLUCOKINASE
REGULATORY PROTEIN


(Rattus
norvegicus)
no annotation 5 ASP A 142
ALA A 114
TYR A 136
GLY A 140
GLY A 111
None
1.14A 4mmfB-4lc9A:
undetectable
4mmfB-4lc9A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nml RIBULOSE 5-PHOSPHATE
ISOMERASE


(Toxoplasma
gondii)
PF06026
(Rib_5-P_isom_A)
5 ASP A  91
ALA A 239
GLY A 233
PHE A 235
GLY A  99
MLT  A 303 (-4.5A)
None
None
None
None
1.17A 4mmfB-4nmlA:
undetectable
4mmfB-4nmlA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ohn ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN


(Streptococcus
pneumoniae)
PF00497
(SBP_bac_3)
5 ALA A  62
TYR A  61
GLY A  44
SER A  47
GLY A  53
None
1.03A 4mmfB-4ohnA:
undetectable
4mmfB-4ohnA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pag PERIPLASMIC BINDING
PROTEIN


(Sulfurospirillum
deleyianum)
PF01497
(Peripla_BP_2)
5 ASP A 286
ALA A 192
TYR A 191
GLY A 229
GLY A 194
None
1.33A 4mmfB-4pagA:
1.3
4mmfB-4pagA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psp ALPHA-FUCOSIDASE
GH29


(Fusarium
graminearum)
PF01120
(Alpha_L_fucos)
PF16757
(Fucosidase_C)
5 ASP A 303
VAL A 167
ALA A 120
TYR A  32
GLY A  30
GOL  A 622 (-2.6A)
None
None
None
None
1.01A 4mmfB-4pspA:
undetectable
4mmfB-4pspA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0c VIRULENCE SENSOR
PROTEIN BVGS


(Bordetella
pertussis)
PF00497
(SBP_bac_3)
5 VAL A 311
ALA A 312
GLY A 330
PHE A 329
GLY A 352
None
1.21A 4mmfB-4q0cA:
undetectable
4mmfB-4q0cA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qav 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2


(Neisseria
meningitidis)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
5 VAL A 351
ALA A 350
TYR A 352
GLY A 236
GLY A 346
None
1.22A 4mmfB-4qavA:
undetectable
4mmfB-4qavA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qax 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE


(Staphylococcus
aureus)
PF01676
(Metalloenzyme)
PF06415
(iPGM_N)
5 ASP A 230
ALA A 222
TYR A 224
GLY A 184
GLY A 219
None
1.18A 4mmfB-4qaxA:
undetectable
4mmfB-4qaxA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiu NITRONATE
MONOOXYGENASE FAMILY
PROTEIN


(Pseudomonas
aeruginosa)
PF03060
(NMO)
5 VAL A  32
ALA A  31
GLY A 239
PHE A 242
SER A  24
None
None
FMN  A 401 (-3.3A)
None
None
1.09A 4mmfB-4qiuA:
undetectable
4mmfB-4qiuA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rjw PORIN O

(Pseudomonas
aeruginosa)
PF07396
(Porin_O_P)
5 ASP A 116
VAL A 189
ALA A 162
TYR A 163
SER A 165
None
1.33A 4mmfB-4rjwA:
undetectable
4mmfB-4rjwA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uoo LIPOTEICHOIC ACID
SYNTHASE


(Listeria
monocytogenes)
PF00884
(Sulfatase)
5 TYR A 380
VAL A 351
ALA A 350
GLY A 354
SER A 401
None
1.24A 4mmfB-4uooA:
undetectable
4mmfB-4uooA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usq PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE


(Cellvibrio sp.
BR)
PF13738
(Pyr_redox_3)
5 VAL A 286
ALA A 285
GLY A 150
PHE A 268
GLY A 156
None
1.26A 4mmfB-4usqA:
undetectable
4mmfB-4usqA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER


(Drosophila
melanogaster)
PF00209
(SNF)
5 ASP A  46
TYR A 124
GLY A 322
SER A 421
GLY A 424
41U  A 605 ( 3.3A)
41U  A 605 ( 3.8A)
41U  A 605 ( 4.1A)
NA  A 602 ( 2.4A)
None
1.03A 4mmfB-4xnuA:
40.7
4mmfB-4xnuA:
29.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER


(Drosophila
melanogaster)
PF00209
(SNF)
6 ASP A  46
VAL A 120
TYR A 124
GLY A 322
SER A 421
GLY A 425
41U  A 605 ( 3.3A)
41U  A 605 (-4.2A)
41U  A 605 ( 3.8A)
41U  A 605 ( 4.1A)
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
0.66A 4mmfB-4xnuA:
40.7
4mmfB-4xnuA:
29.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa6 VANADIUM-DEPENDENT
BROMOPEROXIDASE 2


(Ascophyllum
nodosum)
no annotation 5 ASP A 155
VAL A  73
ALA A  72
GLY A 153
GLY A  69
None
1.32A 4mmfB-5aa6A:
undetectable
4mmfB-5aa6A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3h PROTEIN SCARECROW

(Arabidopsis
thaliana)
PF03514
(GRAS)
5 VAL A 517
ALA A 648
GLY A 599
PHE A 600
GLY A 602
None
1.20A 4mmfB-5b3hA:
undetectable
4mmfB-5b3hA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ce6 FACT-SPT16

(Cicer arietinum)
PF00557
(Peptidase_M24)
PF14826
(FACT-Spt16_Nlob)
5 VAL A  55
ALA A  54
GLY A 189
PHE A 190
GLY A 157
None
1.30A 4mmfB-5ce6A:
undetectable
4mmfB-5ce6A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ee7 GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR


(Escherichia
virus T4;
Homo sapiens)
PF00002
(7tm_2)
PF00959
(Phage_lysozyme)
5 ALA A 237
TYR A 239
GLY A 393
PHE A 184
GLY A 234
None
PE5  A1216 (-4.7A)
None
None
None
1.40A 4mmfB-5ee7A:
undetectable
4mmfB-5ee7A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epg ALDEHYDE OXIDASE

(Homo sapiens)
PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C)
5 ASP A1093
VAL A1163
TYR A1161
SER A1265
GLY A1192
None
1.03A 4mmfB-5epgA:
1.0
4mmfB-5epgA:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ham RICKCE

(Rickettsia
bellii)
no annotation 5 ASP A 624
GLY A 656
PHE A 631
SER A 626
GLY A 629
None
1.01A 4mmfB-5hamA:
undetectable
4mmfB-5hamA:
20.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i6z SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER


(Homo sapiens)
PF00209
(SNF)
6 TYR A  95
ASP A  98
ALA A 173
TYR A 176
GLY A 338
SER A 438
None
0.82A 4mmfB-5i6zA:
42.0
4mmfB-5i6zA:
30.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i6z SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER


(Homo sapiens)
PF00209
(SNF)
6 TYR A  95
ASP A  98
TYR A 176
GLY A 338
SER A 438
GLY A 442
None
0.66A 4mmfB-5i6zA:
42.0
4mmfB-5i6zA:
30.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqp GLYCOSIDE HYDROLASE
BT_1002


(Bacteroides
thetaiotaomicron)
no annotation 5 VAL A 524
ALA A 525
TYR A 528
GLY A 464
GLY A 490
None
1.32A 4mmfB-5mqpA:
undetectable
4mmfB-5mqpA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5c PUTATIVE
DECARBOXYLASE
INVOLVED IN
DESFERRIOXAMINE
BIOSYNTHESIS


(Erwinia
amylovora)
no annotation 5 VAL A 466
ALA A 465
PHE A 460
SER A  58
GLY A 463
None
1.33A 4mmfB-5o5cA:
undetectable
4mmfB-5o5cA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wab PUTATIVE
BETA-GLUCOSIDASE


(Bifidobacterium
adolescentis)
no annotation 5 VAL A 102
ALA A 103
GLY A  45
SER A 151
GLY A 149
None
1.27A 4mmfB-5wabA:
undetectable
4mmfB-5wabA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zby HYDROGENASE
MATURATION PROTEASE
HYCI


(Thermococcus
kodakarensis)
no annotation 5 VAL A  33
ALA A  34
GLY A 124
PHE A  29
GLY A  18
None
0.96A 4mmfB-5zbyA:
undetectable
4mmfB-5zbyA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en9 HYDROGENASE-2 SMALL
CHAIN


(Escherichia
coli)
no annotation 5 VAL S 126
ALA S 127
GLY S 153
SER S 121
GLY S 124
None
1.37A 4mmfB-6en9S:
undetectable
4mmfB-6en9S:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en9 HYDROGENASE-2 SMALL
CHAIN


(Escherichia
coli)
no annotation 5 VAL S 126
ALA S 128
GLY S 153
SER S 121
GLY S 124
None
1.39A 4mmfB-6en9S:
undetectable
4mmfB-6en9S:
9.65