SIMILAR PATTERNS OF AMINO ACIDS FOR 4MME_A_29QA603

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bev BOVINE ENTEROVIRUS
COAT PROTEINS VP1 TO
VP4

(Enterovirus E) 		PF00073
(Rhv) 		5 ALA 1 254
GLY 3  63
PHE 2 156
SER 1 268
GLY 1 266
 None
 0.99A 4mmeA-1bev1:
undetectable		 4mmeA-1bev1:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1biy LACTOFERRIN

(Bubalus bubalis) 		PF00405
(Transferrin) 		5 VAL A 540
ALA A 541
GLY A 453
SER A 490
GLY A 538
 None
 1.18A 4mmeA-1biyA:
0.0		 4mmeA-1biyA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cp9 PENICILLIN G AMIDASE

(Providencia
rettgeri) 		PF01804
(Penicil_amidase) 		5 ASP A  36
VAL B 499
ALA B 500
GLY A  13
SER B 504
 None
 1.30A 4mmeA-1cp9A:
undetectable		 4mmeA-1cp9A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbi AK.1 SERINE PROTEASE

(Bacillus sp.
Ak1) 		PF00082
(Peptidase_S8) 		5 ASP A  48
VAL A 211
ALA A 220
TYR A 219
GLY A  92
 CA  A 701 (-2.2A)
None
None
None
None
 1.04A 4mmeA-1dbiA:
undetectable		 4mmeA-1dbiA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3j NADP(H)-DEPENDENT
KETOSE REDUCTASE

(Bemisia
argentifolii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 VAL A 219
ALA A 199
GLY A 257
SER A 248
GLY A 176
 None
PO4  A 903 (-3.4A)
None
None
PO4  A 903 ( 3.9A)
 1.19A 4mmeA-1e3jA:
0.0		 4mmeA-1e3jA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e9y UREASE SUBUNIT BETA

(Helicobacter
pylori) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		5 VAL B 237
ALA B 238
TYR B 241
SER B 495
GLY B 217
 None
 1.39A 4mmeA-1e9yB:
0.0		 4mmeA-1e9yB:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fi8 ECOTIN
NATURAL KILLER CELL
PROTEASE 1

(Escherichia
coli;
Rattus
norvegicus) 		PF00089
(Trypsin)
PF03974
(Ecotin) 		5 ASP C  84
VAL A 138
GLY A 142
SER A 195
GLY A 197
 None
 1.12A 4mmeA-1fi8C:
undetectable		 4mmeA-1fi8C:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fq9 FIBROBLAST GROWTH
FACTOR RECEPTOR 1

(Homo sapiens) 		PF07679
(I-set) 		5 ASP C 335
VAL C 267
ALA C 268
GLY C 337
SER C 332
 None
 1.42A 4mmeA-1fq9C:
undetectable		 4mmeA-1fq9C:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hxh 3BETA/17BETA-HYDROXY
STEROID
DEHYDROGENASE

(Comamonas
testosteroni) 		PF13561
(adh_short_C2) 		5 VAL A  23
GLY A  43
PHE A  35
SER A  16
GLY A  13
 None
 1.39A 4mmeA-1hxhA:
0.0		 4mmeA-1hxhA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hzf COMPLEMENT FACTOR
C4A

(Homo sapiens) 		PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		5 ALA A1005
TYR A1008
GLY A1274
PHE A1280
SER A 977
 None
 0.85A 4mmeA-1hzfA:
0.3		 4mmeA-1hzfA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i1h PRECORRIN-8X
METHYLMUTASE

(Pseudomonas
denitrificans
(nomen
rejiciendum)) 		PF02570
(CbiC) 		5 ASP A 174
VAL A  55
ALA A 186
GLY A 190
GLY A 161
 None
 1.27A 4mmeA-1i1hA:
0.0		 4mmeA-1i1hA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i36 CONSERVED
HYPOTHETICAL PROTEIN
MTH1747

(Methanothermobacter
thermautotrophicus) 		PF03807
(F420_oxidored)
PF09130
(DUF1932) 		5 ASP A  86
VAL A  11
ALA A  12
SER A  62
GLY A   7
 None
NAP  A1350 (-3.8A)
None
None
NAP  A1350 (-3.4A)
 1.12A 4mmeA-1i36A:
undetectable		 4mmeA-1i36A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jkm BREFELDIN A ESTERASE

(Bacillus
subtilis) 		PF07859
(Abhydrolase_3) 		5 VAL A 269
ALA A 266
TYR A 238
GLY A 127
GLY A 264
 None
 1.34A 4mmeA-1jkmA:
undetectable		 4mmeA-1jkmA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1j FIBRINOGEN BETA
CHAIN

(Gallus gallus) 		PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		5 ASP B 246
VAL B 243
TYR B 244
GLY B 253
SER B 227
 None
 1.23A 4mmeA-1m1jB:
undetectable		 4mmeA-1m1jB:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n76 LACTOFERRIN

(Homo sapiens) 		PF00405
(Transferrin) 		5 VAL A 542
ALA A 543
GLY A 455
SER A 492
GLY A 540
 None
 1.27A 4mmeA-1n76A:
undetectable		 4mmeA-1n76A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ox4 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
HISHF

(Saccharomyces
cerevisiae) 		PF00117
(GATase)
PF00977
(His_biosynth) 		5 VAL B 368
ALA B 367
TYR B 369
GLY B 443
GLY B 364
 None
None
None
None
SO4  B 804 (-3.8A)
 1.04A 4mmeA-1ox4B:
undetectable		 4mmeA-1ox4B:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qjm LACTOFERRIN

(Equus caballus) 		PF00405
(Transferrin) 		5 VAL A 540
ALA A 541
GLY A 453
SER A 490
GLY A 538
 None
 1.37A 4mmeA-1qjmA:
undetectable		 4mmeA-1qjmA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rkq HYPOTHETICAL PROTEIN
YIDA

(Escherichia
coli) 		PF08282
(Hydrolase_3) 		5 VAL A  26
ALA A 262
GLY A  13
SER A 255
GLY A 260
 None
None
MG  A1273 ( 4.5A)
None
None
 1.41A 4mmeA-1rkqA:
undetectable		 4mmeA-1rkqA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sy7 CATALASE 1

(Neurospora
crassa) 		PF00199
(Catalase)
PF01965
(DJ-1_PfpI)
PF06628
(Catalase-rel) 		5 VAL A 671
TYR A 683
GLY A 647
PHE A 646
GLY A 684
 None
 1.40A 4mmeA-1sy7A:
undetectable		 4mmeA-1sy7A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tki TITIN

(Homo sapiens) 		PF00069
(Pkinase) 		5 ASP A 144
VAL A 191
ALA A 188
TYR A 187
GLY A 141
 None
 1.25A 4mmeA-1tkiA:
undetectable		 4mmeA-1tkiA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u9c APC35852

(Geobacillus
stearothermophilus) 		PF01965
(DJ-1_PfpI) 		5 VAL A 192
GLY A 184
PHE A 190
SER A 151
GLY A 200
 None
 1.16A 4mmeA-1u9cA:
undetectable		 4mmeA-1u9cA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vdk FUMARATE HYDRATASE
CLASS II

(Thermus
thermophilus) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		5 ASP A 142
VAL A 246
ALA A 247
GLY A 137
PHE A 242
 None
 1.23A 4mmeA-1vdkA:
undetectable		 4mmeA-1vdkA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w0m TRIOSEPHOSPHATE
ISOMERASE

(Thermoproteus
tenax) 		PF00121
(TIM)
PF05690
(ThiG) 		5 VAL A  89
ALA A  61
TYR A  60
GLY A 114
GLY A  86
 None
 1.14A 4mmeA-1w0mA:
undetectable		 4mmeA-1w0mA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT

(Thermotoga
maritima) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC) 		5 ALA A 617
TYR A 614
GLY A 246
PHE A 247
GLY A 624
 None
 1.16A 4mmeA-1xjeA:
undetectable		 4mmeA-1xjeA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkq SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5D234)

(Caenorhabditis
elegans) 		PF13561
(adh_short_C2) 		5 ASP A 170
VAL A 257
ALA A 258
GLY A 152
SER A 147
 None
 1.32A 4mmeA-1xkqA:
undetectable		 4mmeA-1xkqA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xrc S-ADENOSYLMETHIONINE
SYNTHETASE

(Escherichia
coli) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		5 ASP A 238
VAL A  10
ALA A 164
GLY A 240
GLY A  13
 None
 1.41A 4mmeA-1xrcA:
0.6		 4mmeA-1xrcA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b2x ANTIBODY AQC2 FAB
INTEGRIN ALPHA-1

(Mus musculus;
Rattus
norvegicus) 		PF00092
(VWA)
PF07654
(C1-set)
PF07686
(V-set) 		5 ASP H 101
VAL H  50
GLY A 220
SER A 158
GLY H  53
 MG  A 400 (-3.6A)
None
None
MG  A 400 (-2.5A)
None
 1.42A 4mmeA-2b2xH:
undetectable		 4mmeA-2b2xH:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cdp BETA-AGARASE 1

(Saccharophagus
degradans) 		PF03422
(CBM_6) 		5 TYR A  63
VAL A 108
PHE A  76
SER A  62
GLY A 105
 None
CL  A1144 ( 4.2A)
None
None
EDO  A1141 (-4.0A)
 1.01A 4mmeA-2cdpA:
undetectable		 4mmeA-2cdpA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cy8 D-PHENYLGLYCINE
AMINOTRANSFERASE

(Pseudomonas
stutzeri) 		PF00202
(Aminotran_3) 		5 ASP A 201
ALA A 231
GLY A 138
SER A 200
GLY A 235
 None
 1.12A 4mmeA-2cy8A:
undetectable		 4mmeA-2cy8A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dne DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE
COMPONENT OF
PYRUVATE
DEHYDROGENASE
COMPLEX

(Homo sapiens) 		PF00364
(Biotin_lipoyl) 		5 ASP A  72
VAL A  66
ALA A  67
GLY A  22
GLY A  69
 None
 1.23A 4mmeA-2dneA:
undetectable		 4mmeA-2dneA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epj GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Aeropyrum
pernix) 		PF00202
(Aminotran_3) 		5 VAL A 268
ALA A 281
GLY A 150
SER A 120
GLY A 270
 None
None
PMP  A 501 ( 3.9A)
PMP  A 501 ( 3.8A)
None
 1.39A 4mmeA-2epjA:
undetectable		 4mmeA-2epjA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lfu GNA2132

(Neisseria
meningitidis) 		PF01298
(TbpB_B_D) 		5 ALA A 341
TYR A 319
GLY A 403
PHE A 420
GLY A 321
 None
 1.19A 4mmeA-2lfuA:
undetectable		 4mmeA-2lfuA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nxo HYPOTHETICAL PROTEIN
SCO4506

(Streptomyces
coelicolor) 		PF02621
(VitK2_biosynth) 		5 VAL A 187
ALA A 186
GLY A 250
PHE A 249
GLY A  78
 None
 1.31A 4mmeA-2nxoA:
undetectable		 4mmeA-2nxoA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o20 CATABOLITE CONTROL
PROTEIN A

(Lactococcus
lactis) 		PF00532
(Peripla_BP_1) 		5 VAL A 218
ALA A 184
TYR A 185
GLY A 221
SER A 246
 None
 1.40A 4mmeA-2o20A:
undetectable		 4mmeA-2o20A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6l UDP-GLUCURONOSYLTRAN
SFERASE 2B7

(Homo sapiens) 		PF00201
(UDPGT) 		5 ASP A 435
VAL A 413
ALA A 412
SER A 437
GLY A 410
 None
 1.28A 4mmeA-2o6lA:
undetectable		 4mmeA-2o6lA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z22 PERIPLASMIC
PHOSPHATE-BINDING
PROTEIN

(Yersinia pestis) 		no annotation 5 ASP X  56
ALA X   7
GLY X 138
SER X  55
GLY X  41
 PO4  X2322 (-2.8A)
None
None
None
None
 1.34A 4mmeA-2z22X:
undetectable		 4mmeA-2z22X:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ziu CROSSOVER JUNCTION
ENDONUCLEASE EME1
MUS81 PROTEIN

(Danio rerio;
Homo sapiens) 		PF02732
(ERCC4) 		5 ASP B 464
ALA A 537
GLY B 468
SER B 463
GLY A 548
 None
 1.42A 4mmeA-2ziuB:
undetectable		 4mmeA-2ziuB:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bvh FIBRINOGEN BETA
CHAIN

(Homo sapiens) 		PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		5 ASP B 241
VAL B 238
TYR B 239
GLY B 248
SER B 222
 None
 1.23A 4mmeA-3bvhB:
undetectable		 4mmeA-3bvhB:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3chx PMOC

(Methylosinus
trichosporium) 		PF04896
(AmoC) 		5 ALA C 117
TYR C 119
PHE C 125
SER C 123
GLY C 121
 None
 1.30A 4mmeA-3chxC:
undetectable		 4mmeA-3chxC:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctd PUTATIVE ATPASE, AAA
FAMILY

(Prochlorococcus
marinus) 		PF12002
(MgsA_C)
PF16193
(AAA_assoc_2) 		6 ASP A 311
VAL A 318
ALA A 340
TYR A 343
GLY A 308
SER A 347
 None
 1.40A 4mmeA-3ctdA:
undetectable		 4mmeA-3ctdA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dnp STRESS RESPONSE
PROTEIN YHAX

(Bacillus
subtilis) 		PF08282
(Hydrolase_3) 		5 ASP A 259
ALA A 264
GLY A  12
SER A 257
GLY A 262
 None
 1.40A 4mmeA-3dnpA:
undetectable		 4mmeA-3dnpA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ed4 ARYLSULFATASE

(Escherichia
coli) 		PF00884
(Sulfatase) 		5 VAL A 192
ALA A 246
GLY A 272
PHE A 270
SER A 243
 None
 1.23A 4mmeA-3ed4A:
undetectable		 4mmeA-3ed4A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ege PUTATIVE
METHYLTRANSFERASE
FROM ANTIBIOTIC
BIOSYNTHESIS PATHWAY

(Trichormus
variabilis) 		PF08241
(Methyltransf_11) 		5 VAL A  58
ALA A  38
TYR A  59
GLY A  34
GLY A  96
 None
 1.40A 4mmeA-3egeA:
undetectable		 4mmeA-3egeA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fd5 SELENIDE, WATER
DIKINASE 1

(Homo sapiens) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 VAL A 302
ALA A 305
GLY A  28
PHE A 310
GLY A 307
 None
 1.21A 4mmeA-3fd5A:
undetectable		 4mmeA-3fd5A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1b ATP-DEPENDENT CLP
PROTEASE ADAPTER
PROTEIN CLPS

(Caulobacter
vibrioides) 		PF02617
(ClpS) 		5 TYR A  89
VAL A 101
ALA A  99
GLY A  87
PHE A  64
 None
 1.40A 4mmeA-3g1bA:
undetectable		 4mmeA-3g1bA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwf CYCLOHEXANONE
MONOOXYGENASE

(Rhodococcus sp.
HI-31) 		PF00743
(FMO-like) 		5 ASP A  59
VAL A 246
ALA A 247
GLY A 277
GLY A 249
 NAP  A 542 ( 3.0A)
None
None
None
None
 1.38A 4mmeA-3gwfA:
undetectable		 4mmeA-3gwfA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN

(Geobacter
sulfurreducens) 		PF08668
(HDOD) 		5 ASP A 152
ALA A 129
GLY A 246
SER A 122
GLY A 124
 FE  A 306 ( 2.5A)
None
None
None
None
 1.14A 4mmeA-3hc1A:
undetectable		 4mmeA-3hc1A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hgq HDA1 COMPLEX SUBUNIT
3

(Saccharomyces
cerevisiae) 		PF11496
(HDA2-3) 		5 ASP A 245
VAL A 266
ALA A 269
GLY A  81
SER A 243
 None
 1.27A 4mmeA-3hgqA:
undetectable		 4mmeA-3hgqA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hly FLAVODOXIN-LIKE
DOMAIN

(Synechococcus
elongatus) 		no annotation 5 ASP A 275
TYR A 267
GLY A 272
SER A 278
GLY A 318
 None
 1.35A 4mmeA-3hlyA:
undetectable		 4mmeA-3hlyA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ljp CHOLINE OXIDASE

(Arthrobacter
globiformis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 ALA A 447
TYR A 456
GLY A 365
SER A 442
GLY A 444
 None
 1.29A 4mmeA-3ljpA:
undetectable		 4mmeA-3ljpA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdn GLUTAMINE
AMINOTRANSFERASE
CLASS-II DOMAIN
PROTEIN

(Ruegeria
pomeroyi) 		PF13230
(GATase_4) 		5 ASP A  50
VAL A  73
ALA A  74
GLY A  56
SER A  79
 None
 1.24A 4mmeA-3mdnA:
undetectable		 4mmeA-3mdnA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpl VIRULENCE SENSOR
PROTEIN BVGS

(Bordetella
pertussis) 		PF00497
(SBP_bac_3) 		5 VAL A 311
ALA A 312
GLY A 330
PHE A 329
GLY A 352
 None
 1.25A 4mmeA-3mplA:
undetectable		 4mmeA-3mplA:
18.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mpn TRANSPORTER

(Aquifex
aeolicus) 		PF00209
(SNF) 		5 VAL A 104
ALA A 105
TYR A 108
PHE A 259
SER A 355
 None
None
LEU  A 601 (-4.5A)
LEU  A 601 (-3.6A)
NA  A 751 ( 2.3A)
 0.45A 4mmeA-3mpnA:
61.2		 4mmeA-3mpnA:
98.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q75 FARNESYLTRANSFERASE
BETA SUBUNIT

(Cryptococcus
neoformans) 		PF00432
(Prenyltrans) 		5 ASP B  42
VAL B 386
ALA B 387
SER B  38
GLY B 311
 None
 1.34A 4mmeA-3q75B:
undetectable		 4mmeA-3q75B:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tox SHORT CHAIN
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		5 VAL A 156
TYR A 159
PHE A 153
SER A 145
GLY A 148
 None
NAP  A 601 (-4.7A)
None
NAP  A 601 (-3.3A)
None
 1.23A 4mmeA-3toxA:
undetectable		 4mmeA-3toxA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN

(Escherichia
coli) 		PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		5 ASP A 360
ALA A 273
GLY A 222
SER A 374
GLY A 376
 None
 1.37A 4mmeA-3ttfA:
1.0		 4mmeA-3ttfA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uog ALCOHOL
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ASP A  46
ALA A  14
GLY A 114
PHE A  62
GLY A  53
 None
 1.38A 4mmeA-3uogA:
undetectable		 4mmeA-3uogA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vml 3-ISOPROPYLMALATE
DEHYDROGENASE

(Shewanella
benthica;
Shewanella
oneidensis) 		PF00180
(Iso_dh) 		5 VAL A 297
ALA A 298
GLY A 335
SER A 261
GLY A 263
 None
 1.41A 4mmeA-3vmlA:
undetectable		 4mmeA-3vmlA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wh9 ENDO-BETA-1,4-MANNAN
ASE

(Aspergillus
niger) 		PF00150
(Cellulase) 		5 ASP A  91
VAL A 150
TYR A 154
GLY A  86
GLY A  55
 None
 1.34A 4mmeA-3wh9A:
undetectable		 4mmeA-3wh9A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7

(Caenorhabditis
elegans) 		PF13649
(Methyltransf_25) 		5 ASP A 276
GLY A 279
PHE A 282
SER A 172
GLY A 174
 None
 1.37A 4mmeA-3wstA:
undetectable		 4mmeA-3wstA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wyw GLUTATHIONE
S-TRANSFERASE

(Nilaparvata
lugens) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		5 TYR A 107
VAL A 171
ALA A 170
GLY A 111
SER A 164
 None
 1.20A 4mmeA-3wywA:
undetectable		 4mmeA-3wywA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zlb PHOSPHOGLYCERATE
KINASE

(Streptococcus
pneumoniae) 		PF00162
(PGK) 		5 VAL A 290
ALA A 289
TYR A 233
GLY A 300
GLY A 287
 None
None
None
None
MG  A1400 ( 4.3A)
 1.13A 4mmeA-3zlbA:
undetectable		 4mmeA-3zlbA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13

(Mycobacterium
tuberculosis) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		5 VAL A 596
ALA A 482
TYR A 484
GLY A 567
GLY A 486
 None
 1.15A 4mmeA-3zukA:
1.2		 4mmeA-3zukA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bn7 COPPER INDUCED
NITROREDUCTASE D

(Lactococcus
lactis) 		PF00881
(Nitroreductase) 		5 ALA A 142
GLY A  97
PHE A 179
SER A 181
GLY A 147
 None
 1.17A 4mmeA-4bn7A:
undetectable		 4mmeA-4bn7A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2o ALPHA-AMYLASE

(Geobacillus
thermoleovorans) 		PF00128
(Alpha-amylase) 		5 ASP A 113
VAL A  57
TYR A  65
GLY A 117
GLY A  68
 None
 1.31A 4mmeA-4e2oA:
undetectable		 4mmeA-4e2oA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eel BETA-PHOSPHOGLUCOMUT
ASE-RELATED PROTEIN

(Deinococcus
radiodurans) 		PF13419
(HAD_2) 		5 VAL A  27
ALA A  25
GLY A  86
SER A  20
GLY A  22
 None
 1.29A 4mmeA-4eelA:
undetectable		 4mmeA-4eelA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ex4 MALATE SYNTHASE G

(Mycobacterium
leprae) 		PF01274
(Malate_synthase) 		5 ASP A 456
VAL A 459
ALA A 514
GLY A 430
SER A 101
 None
 1.31A 4mmeA-4ex4A:
undetectable		 4mmeA-4ex4A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ezb UNCHARACTERIZED
CONSERVED PROTEIN

(Sinorhizobium
meliloti) 		PF03807
(F420_oxidored)
PF09130
(DUF1932) 		5 ASP A  96
ALA A  13
GLY A  74
SER A  70
GLY A   8
 None
 1.19A 4mmeA-4ezbA:
undetectable		 4mmeA-4ezbA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hz9 PUTATIVE CYTOPLASMIC
PROTEIN

(Ralstonia
pickettii) 		no annotation 5 VAL A  68
GLY A  55
PHE A  56
SER A  50
GLY A  48
 None
 1.42A 4mmeA-4hz9A:
undetectable		 4mmeA-4hz9A:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kh3 ANTIGEN 43

(Escherichia
coli) 		PF16168
(AIDA) 		5 ASP A 339
VAL A 344
GLY A 322
SER A 340
GLY A 357
 None
 1.25A 4mmeA-4kh3A:
undetectable		 4mmeA-4kh3A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ohn ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF00497
(SBP_bac_3) 		5 ALA A  62
TYR A  61
GLY A  44
SER A  47
GLY A  53
 None
 0.98A 4mmeA-4ohnA:
undetectable		 4mmeA-4ohnA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pag PERIPLASMIC BINDING
PROTEIN

(Sulfurospirillum
deleyianum) 		PF01497
(Peripla_BP_2) 		5 ASP A 286
ALA A 192
TYR A 191
GLY A 229
GLY A 194
 None
 1.33A 4mmeA-4pagA:
undetectable		 4mmeA-4pagA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pe3 TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT

(Rhodobacter
sphaeroides) 		PF03480
(DctP) 		5 ALA A 330
GLY A 254
PHE A 255
SER A 257
GLY A 132
 None
None
None
ZN  A 405 ( 4.4A)
None
 1.42A 4mmeA-4pe3A:
undetectable		 4mmeA-4pe3A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psp ALPHA-FUCOSIDASE
GH29

(Fusarium
graminearum) 		PF01120
(Alpha_L_fucos)
PF16757
(Fucosidase_C) 		5 ASP A 303
VAL A 167
ALA A 120
TYR A  32
GLY A  30
 GOL  A 622 (-2.6A)
None
None
None
None
 1.00A 4mmeA-4pspA:
undetectable		 4mmeA-4pspA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0c VIRULENCE SENSOR
PROTEIN BVGS

(Bordetella
pertussis) 		PF00497
(SBP_bac_3) 		5 VAL A 311
ALA A 312
GLY A 330
PHE A 329
GLY A 352
 None
 1.24A 4mmeA-4q0cA:
undetectable		 4mmeA-4q0cA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qav 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Neisseria
meningitidis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 VAL A 351
ALA A 350
TYR A 352
GLY A 236
GLY A 346
 None
 1.16A 4mmeA-4qavA:
undetectable		 4mmeA-4qavA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rjw PORIN O

(Pseudomonas
aeruginosa) 		PF07396
(Porin_O_P) 		5 ASP A 116
VAL A 189
ALA A 162
TYR A 163
SER A 165
 None
 1.30A 4mmeA-4rjwA:
undetectable		 4mmeA-4rjwA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Rhizobium etli) 		PF01547
(SBP_bac_1) 		5 VAL A 339
ALA A 340
GLY A 310
PHE A 144
SER A 146
 None
 1.28A 4mmeA-4rk2A:
undetectable		 4mmeA-4rk2A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uoo LIPOTEICHOIC ACID
SYNTHASE

(Listeria
monocytogenes) 		PF00884
(Sulfatase) 		5 TYR A 380
VAL A 351
ALA A 350
GLY A 354
SER A 401
 None
 1.26A 4mmeA-4uooA:
undetectable		 4mmeA-4uooA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster) 		PF00209
(SNF) 		6 ASP A  46
VAL A 120
TYR A 124
GLY A 322
SER A 421
GLY A 425
 41U  A 605 ( 3.3A)
41U  A 605 (-4.2A)
41U  A 605 ( 3.8A)
41U  A 605 ( 4.1A)
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
 0.54A 4mmeA-4xnuA:
40.9		 4mmeA-4xnuA:
29.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa6 VANADIUM-DEPENDENT
BROMOPEROXIDASE 2

(Ascophyllum
nodosum) 		no annotation 5 ASP A 155
VAL A  73
ALA A  72
GLY A 153
GLY A  69
 None
 1.37A 4mmeA-5aa6A:
0.5		 4mmeA-5aa6A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3h PROTEIN SCARECROW

(Arabidopsis
thaliana) 		PF03514
(GRAS) 		5 VAL A 517
ALA A 648
GLY A 599
PHE A 600
GLY A 602
 None
 1.22A 4mmeA-5b3hA:
undetectable		 4mmeA-5b3hA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dud YBGK

(Escherichia
coli) 		PF02626
(CT_A_B) 		5 ASP A  15
VAL A 121
GLY A 126
SER A 129
GLY A 137
 None
 1.19A 4mmeA-5dudA:
undetectable		 4mmeA-5dudA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epg ALDEHYDE OXIDASE

(Homo sapiens) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 ASP A1093
VAL A1163
TYR A1161
SER A1265
GLY A1192
 None
 1.02A 4mmeA-5epgA:
undetectable		 4mmeA-5epgA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5evl BETA-LACTAMASE

(Chromobacterium
violaceum) 		PF00144
(Beta-lactamase) 		5 ALA A  90
TYR A  93
GLY A  75
PHE A 159
SER A 166
 None
 1.42A 4mmeA-5evlA:
0.5		 4mmeA-5evlA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h36 UNCHARACTERIZED
PROTEIN TRIC

(Rhodobacter
sphaeroides) 		no annotation 5 ASP E 137
ALA E  22
GLY E 132
PHE E  17
GLY E  39
 None
 1.17A 4mmeA-5h36E:
undetectable		 4mmeA-5h36E:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ham RICKCE

(Rickettsia
bellii) 		no annotation 5 ASP A 624
GLY A 656
PHE A 631
SER A 626
GLY A 629
 None
 0.97A 4mmeA-5hamA:
undetectable		 4mmeA-5hamA:
20.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i6z SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER

(Homo sapiens) 		PF00209
(SNF) 		6 TYR A  95
ASP A  98
ALA A 169
GLY A 338
SER A 438
GLY A 442
 None
 1.40A 4mmeA-5i6zA:
42.2		 4mmeA-5i6zA:
31.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i6z SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER

(Homo sapiens) 		PF00209
(SNF) 		7 TYR A  95
ASP A  98
ALA A 173
TYR A 176
GLY A 338
SER A 438
GLY A 442
 None
 0.70A 4mmeA-5i6zA:
42.2		 4mmeA-5i6zA:
31.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1c WD REPEAT-CONTAINING
PROTEIN 20

(Homo sapiens) 		PF00400
(WD40) 		5 ASP C 382
VAL C 288
ALA C 298
GLY C 370
GLY C 300
 None
 1.33A 4mmeA-5k1cC:
undetectable		 4mmeA-5k1cC:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA

(Methylobacillus
flagellatus) 		PF00364
(Biotin_lipoyl)
PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		5 VAL C 574
ALA C 573
GLY C 592
SER C 589
GLY C 571
 None
 1.38A 4mmeA-5ks8C:
undetectable		 4mmeA-5ks8C:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m2n ELONGATOR COMPLEX
PROTEIN 2

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		5 ASP A 777
VAL A  51
GLY A  35
SER A 779
GLY A 383
 None
 1.25A 4mmeA-5m2nA:
undetectable		 4mmeA-5m2nA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqp GLYCOSIDE HYDROLASE
BT_1002

(Bacteroides
thetaiotaomicron) 		no annotation 5 VAL A 524
ALA A 525
TYR A 528
GLY A 464
GLY A 490
 None
 1.38A 4mmeA-5mqpA:
undetectable		 4mmeA-5mqpA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o1r GNA2132

(Neisseria
meningitidis) 		no annotation 5 ALA A 341
TYR A 319
GLY A 403
PHE A 420
GLY A 321
 None
 1.30A 4mmeA-5o1rA:
undetectable		 4mmeA-5o1rA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8t S-ADENOSYLMETHIONINE
SYNTHASE

(Neisseria
gonorrhoeae) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		5 ASP A 243
VAL A  11
ALA A 167
GLY A 245
GLY A  14
 None
 1.35A 4mmeA-5t8tA:
0.6		 4mmeA-5t8tA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tu4 PAGF
PRENYLTRANSFERASE

(Planktothrix
agardhii) 		no annotation 5 VAL A 168
ALA A 187
GLY A 172
SER A 226
GLY A 224
 None
 1.33A 4mmeA-5tu4A:
undetectable		 4mmeA-5tu4A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wab PUTATIVE
BETA-GLUCOSIDASE

(Bifidobacterium
adolescentis) 		no annotation 5 VAL A 102
ALA A 103
GLY A  45
SER A 151
GLY A 149
 None
 1.33A 4mmeA-5wabA:
undetectable		 4mmeA-5wabA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5weo GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF00822
(PMP22_Claudin)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 VAL A 530
ALA A 532
TYR A 533
SER A 537
GLY A 535
 None
 1.21A 4mmeA-5weoA:
undetectable		 4mmeA-5weoA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en9 HYDROGENASE-2 SMALL
CHAIN

(Escherichia
coli) 		no annotation 5 VAL S 126
ALA S 127
GLY S 153
SER S 121
GLY S 124
 None
 1.41A 4mmeA-6en9S:
undetectable		 4mmeA-6en9S:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en9 HYDROGENASE-2 SMALL
CHAIN

(Escherichia
coli) 		no annotation 5 VAL S 126
ALA S 128
GLY S 153
SER S 121
GLY S 124
 None
 1.39A 4mmeA-6en9S:
undetectable		 4mmeA-6en9S:
10.71