SIMILAR PATTERNS OF AMINO ACIDS FOR 4MMB_A_SREA603

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bev BOVINE ENTEROVIRUS
COAT PROTEINS VP1 TO
VP4

(Enterovirus E) 		PF00073
(Rhv) 		5 ALA 1 254
GLY 3  63
PHE 2 156
SER 1 268
GLY 1 266
 None
 0.95A 4mmbA-1bev1:
undetectable		 4mmbA-1bev1:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1biy LACTOFERRIN

(Bubalus bubalis) 		PF00405
(Transferrin) 		5 VAL A 540
ALA A 541
GLY A 453
SER A 490
GLY A 538
 None
 1.18A 4mmbA-1biyA:
0.0		 4mmbA-1biyA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbi AK.1 SERINE PROTEASE

(Bacillus sp.
Ak1) 		PF00082
(Peptidase_S8) 		5 ASP A  48
VAL A 211
ALA A 220
TYR A 219
GLY A  92
 CA  A 701 (-2.2A)
None
None
None
None
 1.07A 4mmbA-1dbiA:
0.0		 4mmbA-1dbiA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3j NADP(H)-DEPENDENT
KETOSE REDUCTASE

(Bemisia
argentifolii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 VAL A 219
ALA A 199
GLY A 257
SER A 248
GLY A 176
 None
PO4  A 903 (-3.4A)
None
None
PO4  A 903 ( 3.9A)
 1.14A 4mmbA-1e3jA:
0.0		 4mmbA-1e3jA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ewk METABOTROPIC
GLUTAMATE RECEPTOR
SUBTYPE 1

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		5 ASP A 407
ALA A 184
GLY A  75
PHE A  51
GLY A 163
 None
 1.20A 4mmbA-1ewkA:
0.0		 4mmbA-1ewkA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8v MATURE CAPSID
PROTEIN BETA
MATURE CAPSID
PROTEIN GAMMA

(Pariacoto virus) 		PF01829
(Peptidase_A6)
no annotation 		5 PRO A 353
VAL A 356
ALA A 355
TYR A 240
GLY D 367
 None
 1.33A 4mmbA-1f8vA:
0.0		 4mmbA-1f8vA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fi8 ECOTIN
NATURAL KILLER CELL
PROTEASE 1

(Escherichia
coli;
Rattus
norvegicus) 		PF00089
(Trypsin)
PF03974
(Ecotin) 		5 ASP C  84
VAL A 138
GLY A 142
SER A 195
GLY A 197
 None
 1.04A 4mmbA-1fi8C:
undetectable		 4mmbA-1fi8C:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gso PROTEIN (GLYCINAMIDE
RIBONUCLEOTIDE
SYNTHETASE)

(Escherichia
coli) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		5 ASP A  58
PRO A  32
VAL A  46
ALA A  47
GLY A  49
 None
 1.35A 4mmbA-1gsoA:
undetectable		 4mmbA-1gsoA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz7 LIPASE 2

(Diutina rugosa) 		PF00135
(COesterase) 		5 PRO A  65
VAL A 296
ALA A 298
PHE A  87
GLY A  67
 None
None
NAG  A1536 ( 4.6A)
None
None
 1.04A 4mmbA-1gz7A:
undetectable		 4mmbA-1gz7A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hzf COMPLEMENT FACTOR
C4A

(Homo sapiens) 		PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		5 ALA A1005
TYR A1008
GLY A1274
PHE A1280
SER A 977
 None
 0.97A 4mmbA-1hzfA:
undetectable		 4mmbA-1hzfA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i36 CONSERVED
HYPOTHETICAL PROTEIN
MTH1747

(Methanothermobacter
thermautotrophicus) 		PF03807
(F420_oxidored)
PF09130
(DUF1932) 		5 ASP A  86
VAL A  11
ALA A  12
SER A  62
GLY A   7
 None
NAP  A1350 (-3.8A)
None
None
NAP  A1350 (-3.4A)
 1.18A 4mmbA-1i36A:
1.3		 4mmbA-1i36A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mn6 POLYKETIDE SYNTHASE
IV

(Streptomyces
venezuelae) 		PF00975
(Thioesterase) 		5 ASP A 207
VAL A  31
ALA A  33
PHE A  28
GLY A 214
 None
 1.21A 4mmbA-1mn6A:
undetectable		 4mmbA-1mn6A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 VAL B 582
ALA B 579
TYR B 650
GLY B 757
GLY B 577
 None
 1.35A 4mmbA-1n60B:
undetectable		 4mmbA-1n60B:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n76 LACTOFERRIN

(Homo sapiens) 		PF00405
(Transferrin) 		5 VAL A 542
ALA A 543
GLY A 455
SER A 492
GLY A 540
 None
 1.25A 4mmbA-1n76A:
undetectable		 4mmbA-1n76A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tki TITIN

(Homo sapiens) 		PF00069
(Pkinase) 		5 ASP A 144
VAL A 191
ALA A 188
TYR A 187
GLY A 141
 None
 1.31A 4mmbA-1tkiA:
undetectable		 4mmbA-1tkiA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vdk FUMARATE HYDRATASE
CLASS II

(Thermus
thermophilus) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		5 ASP A 142
VAL A 246
ALA A 247
GLY A 137
PHE A 242
 None
 1.30A 4mmbA-1vdkA:
undetectable		 4mmbA-1vdkA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vl2 ARGININOSUCCINATE
SYNTHASE

(Thermotoga
maritima) 		PF00764
(Arginosuc_synth) 		5 PRO A 168
ALA A 162
TYR A 161
GLY A  53
GLY A 166
 None
 1.24A 4mmbA-1vl2A:
undetectable		 4mmbA-1vl2A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w0m TRIOSEPHOSPHATE
ISOMERASE

(Thermoproteus
tenax) 		PF00121
(TIM)
PF05690
(ThiG) 		5 VAL A  89
ALA A  61
TYR A  60
GLY A 114
GLY A  86
 None
 1.19A 4mmbA-1w0mA:
undetectable		 4mmbA-1w0mA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5d PENICILLIN-BINDING
PROTEIN

(Bacillus
subtilis) 		PF02113
(Peptidase_S13) 		5 ASP A 200
PRO A 176
VAL A 174
ALA A 185
GLY A 227
 None
 1.32A 4mmbA-1w5dA:
undetectable		 4mmbA-1w5dA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y0l CATALYTIC ANTIBODY
FAB 34E4 HEAVY CHAIN

(Homo sapiens;
Mus musculus) 		no annotation 5 PRO H  14
VAL H 111
ALA H  12
SER H  82
GLY H  16
 None
 1.18A 4mmbA-1y0lH:
undetectable		 4mmbA-1y0lH:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cev PROTEIN (ARGINASE)

([Bacillus]
caldovelox) 		PF00491
(Arginase) 		5 ASP A 226
PRO A 274
ALA A 283
GLY A 239
GLY A  23
 MN  A 302 (-2.9A)
None
None
None
None
 1.33A 4mmbA-2cevA:
undetectable		 4mmbA-2cevA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cy8 D-PHENYLGLYCINE
AMINOTRANSFERASE

(Pseudomonas
stutzeri) 		PF00202
(Aminotran_3) 		5 ASP A 201
ALA A 231
GLY A 138
SER A 200
GLY A 235
 None
 1.20A 4mmbA-2cy8A:
undetectable		 4mmbA-2cy8A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dc0 PROBABLE AMIDASE

(Thermus
thermophilus) 		PF01425
(Amidase) 		5 PRO A 133
ALA A 144
GLY A  86
SER A 147
GLY A 126
 None
 1.19A 4mmbA-2dc0A:
undetectable		 4mmbA-2dc0A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e8y AMYX PROTEIN

(Bacillus
subtilis) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 ASP A 224
PRO A 284
VAL A 279
ALA A 287
TYR A 288
 None
GOL  A 761 (-4.0A)
None
None
None
 1.31A 4mmbA-2e8yA:
undetectable		 4mmbA-2e8yA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e8y AMYX PROTEIN

(Bacillus
subtilis) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 ASP A 224
VAL A 279
ALA A 287
TYR A 288
GLY A 237
 None
None
None
None
GOL  A 761 (-3.7A)
 1.15A 4mmbA-2e8yA:
undetectable		 4mmbA-2e8yA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epj GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Aeropyrum
pernix) 		PF00202
(Aminotran_3) 		5 VAL A 268
ALA A 281
GLY A 150
SER A 120
GLY A 270
 None
None
PMP  A 501 ( 3.9A)
PMP  A 501 ( 3.8A)
None
 1.31A 4mmbA-2epjA:
undetectable		 4mmbA-2epjA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2knq GENERAL SECRETION
PATHWAY PROTEIN H

(Escherichia
coli) 		PF12019
(GspH) 		5 PRO A  37
VAL A  38
ALA A  31
GLY A  53
GLY A  35
 None
 1.27A 4mmbA-2knqA:
undetectable		 4mmbA-2knqA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kt1 PHOSPHATIDYLINOSITOL
3-KINASE REGULATORY
SUBUNIT BETA

(Homo sapiens) 		no annotation 5 ASP A  69
PRO A  51
VAL A  54
GLY A  59
GLY A  72
 None
 1.13A 4mmbA-2kt1A:
undetectable		 4mmbA-2kt1A:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nxo HYPOTHETICAL PROTEIN
SCO4506

(Streptomyces
coelicolor) 		PF02621
(VitK2_biosynth) 		5 VAL A 187
ALA A 186
GLY A 250
PHE A 249
GLY A  78
 None
 1.18A 4mmbA-2nxoA:
undetectable		 4mmbA-2nxoA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p7n PATHOGENICITY ISLAND
1 EFFECTOR PROTEIN

(Chromobacterium
violaceum) 		PF06511
(IpaD) 		5 ASP A 259
PRO A 267
VAL A 264
GLY A 274
GLY A 277
 None
 1.29A 4mmbA-2p7nA:
undetectable		 4mmbA-2p7nA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p8j S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE

(Clostridium
acetobutylicum) 		PF08241
(Methyltransf_11) 		5 ASP A  55
ALA A  61
GLY A  77
SER A  54
GLY A  32
 None
 1.33A 4mmbA-2p8jA:
undetectable		 4mmbA-2p8jA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q0l THIOREDOXIN
REDUCTASE

(Helicobacter
pylori) 		PF07992
(Pyr_redox_2) 		5 ALA A  20
TYR A  19
PHE A  72
SER A  15
GLY A  17
 None
 1.35A 4mmbA-2q0lA:
undetectable		 4mmbA-2q0lA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wv0 HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR YVOA

(Bacillus
subtilis) 		PF00392
(GntR)
PF07702
(UTRA) 		5 PRO A 205
VAL A 206
ALA A 189
GLY A 199
GLY A 203
 None
 1.15A 4mmbA-2wv0A:
0.8		 4mmbA-2wv0A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzo TRANSFORMING GROWTH
FACTOR BETA
REGULATOR 1

(Homo sapiens) 		PF05964
(FYRN)
PF05965
(FYRC) 		5 ASP A 201
PRO A 213
VAL A 214
GLY A 204
PHE A 205
 None
 1.32A 4mmbA-2wzoA:
undetectable		 4mmbA-2wzoA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9f HEMOLYTIC LECTIN
LSLA

(Laetiporus
sulphureus) 		no annotation 5 ASP A  93
PRO A 134
ALA A 119
SER A 115
GLY A 117
 None
 1.28A 4mmbA-2y9fA:
undetectable		 4mmbA-2y9fA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zkt 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Pyrococcus
horikoshii) 		PF01676
(Metalloenzyme)
PF10143
(PhosphMutase) 		5 VAL A 262
ALA A 261
GLY A 248
PHE A 264
GLY A 257
 None
 1.35A 4mmbA-2zktA:
undetectable		 4mmbA-2zktA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aje PUTATIVE
UNCHARACTERIZED
PROTEIN ST1526

(Sulfurisphaera
tokodaii) 		PF01300
(Sua5_yciO_yrdC)
PF03481
(SUA5) 		5 VAL A 294
ALA A 295
GLY A 317
PHE A 318
GLY A 324
 None
 1.09A 4mmbA-3ajeA:
undetectable		 4mmbA-3ajeA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctd PUTATIVE ATPASE, AAA
FAMILY

(Prochlorococcus
marinus) 		PF12002
(MgsA_C)
PF16193
(AAA_assoc_2) 		6 ASP A 311
VAL A 318
ALA A 340
TYR A 343
GLY A 308
SER A 347
 None
 1.39A 4mmbA-3ctdA:
undetectable		 4mmbA-3ctdA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dnf 4-HYDROXY-3-METHYLBU
T-2-ENYL DIPHOSPHATE
REDUCTASE

(Aquifex
aeolicus) 		PF02401
(LYTB) 		5 VAL A  20
ALA A  19
GLY A  11
PHE A  12
GLY A  15
 None
None
None
None
F3S  A2302 (-3.4A)
 1.25A 4mmbA-3dnfA:
undetectable		 4mmbA-3dnfA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ed4 ARYLSULFATASE

(Escherichia
coli) 		PF00884
(Sulfatase) 		5 VAL A 192
ALA A 246
GLY A 272
PHE A 270
SER A 243
 None
 1.26A 4mmbA-3ed4A:
undetectable		 4mmbA-3ed4A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f8r THIOREDOXIN
REDUCTASE (TRXB-3)

(Sulfolobus
solfataricus) 		PF07992
(Pyr_redox_2) 		5 ASP A 164
VAL A 199
TYR A 195
GLY A 162
GLY A 169
 NAP  A4001 (-4.2A)
None
NAP  A4001 (-4.5A)
NAP  A4001 ( 4.6A)
None
 1.34A 4mmbA-3f8rA:
undetectable		 4mmbA-3f8rA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fd5 SELENIDE, WATER
DIKINASE 1

(Homo sapiens) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 VAL A 302
ALA A 305
GLY A  28
PHE A 310
GLY A 307
 None
 1.22A 4mmbA-3fd5A:
undetectable		 4mmbA-3fd5A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fys PROTEIN DEGV

(Bacillus
subtilis) 		PF02645
(DegV) 		5 PRO A 226
VAL A 254
TYR A 251
SER A 222
GLY A 224
 None
 1.05A 4mmbA-3fysA:
undetectable		 4mmbA-3fysA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7a SHORT CHAIN
DEHYDROGENASE

(Rhodopseudomonas
palustris) 		PF00106
(adh_short) 		5 PRO A 214
VAL A 217
ALA A 218
TYR A 221
GLY A  18
 PRO  A 214 ( 1.1A)
VAL  A 217 ( 0.6A)
ALA  A 218 ( 0.0A)
TYR  A 221 ( 1.3A)
GLY  A  18 ( 0.0A)
 1.05A 4mmbA-3h7aA:
undetectable		 4mmbA-3h7aA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hgq HDA1 COMPLEX SUBUNIT
3

(Saccharomyces
cerevisiae) 		PF11496
(HDA2-3) 		5 ASP A 245
VAL A 266
ALA A 269
GLY A  81
SER A 243
 None
 1.36A 4mmbA-3hgqA:
undetectable		 4mmbA-3hgqA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hly FLAVODOXIN-LIKE
DOMAIN

(Synechococcus
elongatus) 		no annotation 6 ASP A 275
PRO A 320
TYR A 267
GLY A 272
SER A 278
GLY A 318
 None
 1.41A 4mmbA-3hlyA:
undetectable		 4mmbA-3hlyA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iml S-ADENOSYLMETHIONINE
SYNTHETASE

(Burkholderia
pseudomallei) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		5 PRO A  17
VAL A  20
ALA A  21
GLY A  50
GLY A 244
 None
 1.30A 4mmbA-3imlA:
undetectable		 4mmbA-3imlA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lhf SERINE RECOMBINASE

(Sulfolobus
solfataricus) 		PF00239
(Resolvase) 		5 ASP A  91
PRO A 123
VAL A 120
ALA A 121
GLY A  95
 None
 1.06A 4mmbA-3lhfA:
undetectable		 4mmbA-3lhfA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdn GLUTAMINE
AMINOTRANSFERASE
CLASS-II DOMAIN
PROTEIN

(Ruegeria
pomeroyi) 		PF13230
(GATase_4) 		5 ASP A  50
VAL A  73
ALA A  74
GLY A  56
SER A  79
 None
 1.22A 4mmbA-3mdnA:
undetectable		 4mmbA-3mdnA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpl VIRULENCE SENSOR
PROTEIN BVGS

(Bordetella
pertussis) 		PF00497
(SBP_bac_3) 		5 VAL A 311
ALA A 312
GLY A 330
PHE A 329
GLY A 352
 None
 1.31A 4mmbA-3mplA:
undetectable		 4mmbA-3mplA:
18.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mpn TRANSPORTER

(Aquifex
aeolicus) 		PF00209
(SNF) 		6 PRO A 101
VAL A 104
ALA A 105
TYR A 108
PHE A 259
SER A 355
 None
None
None
LEU  A 601 (-4.5A)
LEU  A 601 (-3.6A)
NA  A 751 ( 2.3A)
 0.31A 4mmbA-3mpnA:
60.8		 4mmbA-3mpnA:
98.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6j HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Pseudomonas
syringae group
genomosp. 3) 		PF13419
(HAD_2) 		5 ASP A 115
PRO A 195
ALA A 193
GLY A 294
SER A 121
 CA  A   4 (-4.7A)
None
None
None
None
 1.35A 4mmbA-3s6jA:
0.7		 4mmbA-3s6jA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sho TRANSCRIPTIONAL
REGULATOR, RPIR
FAMILY

(Sphaerobacter
thermophilus) 		PF01380
(SIS) 		5 VAL A 148
ALA A 149
PHE A 144
SER A 190
GLY A 141
 None
 1.26A 4mmbA-3shoA:
undetectable		 4mmbA-3shoA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t7b ACETYLGLUTAMATE
KINASE

(Yersinia pestis) 		PF00696
(AA_kinase) 		5 PRO A 230
VAL A 231
ALA A 224
GLY A 172
GLY A 228
 None
 1.15A 4mmbA-3t7bA:
undetectable		 4mmbA-3t7bA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13

(Mycobacterium
tuberculosis) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		5 VAL A 596
ALA A 482
TYR A 484
GLY A 567
GLY A 486
 None
 1.18A 4mmbA-3zukA:
undetectable		 4mmbA-3zukA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a9w MONOOXYGENASE

(Stenotrophomonas
maltophilia) 		PF13738
(Pyr_redox_3) 		5 PRO A  92
TYR A  85
GLY A  11
SER A  17
GLY A  19
 None
None
FAD  A1353 ( 4.7A)
None
None
 1.17A 4mmbA-4a9wA:
undetectable		 4mmbA-4a9wA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4au0 EXOGLUCANASE 2

(Trichoderma
reesei) 		PF01341
(Glyco_hydro_6) 		5 VAL A 127
ALA A 126
GLY A 374
PHE A 375
SER A 445
 None
 1.18A 4mmbA-4au0A:
undetectable		 4mmbA-4au0A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bn7 COPPER INDUCED
NITROREDUCTASE D

(Lactococcus
lactis) 		PF00881
(Nitroreductase) 		5 ALA A 142
GLY A  97
PHE A 179
SER A 181
GLY A 147
 None
 1.25A 4mmbA-4bn7A:
undetectable		 4mmbA-4bn7A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bnq NON-CANONICAL PURINE
NTP PYROPHOSPHATASE

(Staphylococcus
aureus) 		PF01725
(Ham1p_like) 		5 ASP A  67
VAL A  26
GLY A  12
SER A   8
GLY A  28
 None
None
None
PO4  A 800 (-2.4A)
None
 1.12A 4mmbA-4bnqA:
undetectable		 4mmbA-4bnqA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eel BETA-PHOSPHOGLUCOMUT
ASE-RELATED PROTEIN

(Deinococcus
radiodurans) 		PF13419
(HAD_2) 		5 VAL A  27
ALA A  25
GLY A  86
SER A  20
GLY A  22
 None
 1.29A 4mmbA-4eelA:
undetectable		 4mmbA-4eelA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ezb UNCHARACTERIZED
CONSERVED PROTEIN

(Sinorhizobium
meliloti) 		PF03807
(F420_oxidored)
PF09130
(DUF1932) 		5 ASP A  96
ALA A  13
GLY A  74
SER A  70
GLY A   8
 None
 1.18A 4mmbA-4ezbA:
1.3		 4mmbA-4ezbA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ezb UNCHARACTERIZED
CONSERVED PROTEIN

(Sinorhizobium
meliloti) 		PF03807
(F420_oxidored)
PF09130
(DUF1932) 		5 PRO A  55
VAL A  53
ALA A  29
GLY A  10
PHE A   9
 None
 1.31A 4mmbA-4ezbA:
1.3		 4mmbA-4ezbA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fbo PSEUDOMONAS
FLUORESCENS
AGGLUTININ

(Pseudomonas
fluorescens) 		no annotation 5 VAL A   6
ALA A   5
TYR A   4
GLY A 116
PHE A 128
 None
 1.34A 4mmbA-4fboA:
undetectable		 4mmbA-4fboA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g4e ATP-DEPENDENT
PROTEASE SUBUNIT
HSLV

(Escherichia
coli) 		PF00227
(Proteasome) 		5 VAL A   4
ALA A 121
GLY A 156
SER A 124
GLY A 126
 None
 1.22A 4mmbA-4g4eA:
undetectable		 4mmbA-4g4eA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gk9 AGGLUTININ (BOA)

(Burkholderia
oklahomensis) 		no annotation 5 VAL A  81
ALA A  80
TYR A  79
GLY A  57
PHE A  69
 None
 1.35A 4mmbA-4gk9A:
undetectable		 4mmbA-4gk9A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gk9 AGGLUTININ (BOA)

(Burkholderia
oklahomensis) 		no annotation 5 VAL A 148
ALA A 147
TYR A 146
GLY A 257
PHE A 269
 None
 1.34A 4mmbA-4gk9A:
undetectable		 4mmbA-4gk9A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gk9 AGGLUTININ (BOA)

(Burkholderia
oklahomensis) 		no annotation 5 VAL A 214
ALA A 213
TYR A 212
GLY A 190
PHE A 202
 None
 1.35A 4mmbA-4gk9A:
undetectable		 4mmbA-4gk9A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hz9 PUTATIVE CYTOPLASMIC
PROTEIN

(Ralstonia
pickettii) 		no annotation 5 VAL A  68
GLY A  55
PHE A  56
SER A  50
GLY A  48
 None
 1.26A 4mmbA-4hz9A:
undetectable		 4mmbA-4hz9A:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ni5 OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN

(Brucella suis) 		PF13561
(adh_short_C2) 		5 VAL A 178
ALA A 168
TYR A 171
GLY A 132
GLY A 172
 None
 1.28A 4mmbA-4ni5A:
undetectable		 4mmbA-4ni5A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ohn ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF00497
(SBP_bac_3) 		5 ALA A  62
TYR A  61
GLY A  44
SER A  47
GLY A  53
 None
 1.03A 4mmbA-4ohnA:
undetectable		 4mmbA-4ohnA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psp ALPHA-FUCOSIDASE
GH29

(Fusarium
graminearum) 		PF01120
(Alpha_L_fucos)
PF16757
(Fucosidase_C) 		5 ASP A 303
VAL A 167
ALA A 120
TYR A  32
GLY A  30
 GOL  A 622 (-2.6A)
None
None
None
None
 1.09A 4mmbA-4pspA:
undetectable		 4mmbA-4pspA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0c VIRULENCE SENSOR
PROTEIN BVGS

(Bordetella
pertussis) 		PF00497
(SBP_bac_3) 		5 VAL A 311
ALA A 312
GLY A 330
PHE A 329
GLY A 352
 None
 1.27A 4mmbA-4q0cA:
undetectable		 4mmbA-4q0cA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qav 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Neisseria
meningitidis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 VAL A 351
ALA A 350
TYR A 352
GLY A 236
GLY A 346
 None
 1.30A 4mmbA-4qavA:
undetectable		 4mmbA-4qavA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rkk LAFORIN

(Homo sapiens) 		PF00686
(CBM_20)
PF00782
(DSPc) 		5 PRO A 246
VAL A 249
ALA A 248
GLY A 322
PHE A 317
 None
 1.27A 4mmbA-4rkkA:
0.0		 4mmbA-4rkkA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xn3 TAIL SPIKE PROTEIN

(Salmonella
virus HK620) 		no annotation 5 ASP A 561
VAL A 615
ALA A 614
GLY A 556
PHE A 584
 None
 1.10A 4mmbA-4xn3A:
undetectable		 4mmbA-4xn3A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster) 		PF00209
(SNF) 		5 ASP A  46
GLY A 322
PHE A 325
SER A 421
GLY A 425
 41U  A 605 ( 3.3A)
41U  A 605 ( 4.1A)
41U  A 605 ( 4.7A)
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
 0.79A 4mmbA-4xnuA:
40.9		 4mmbA-4xnuA:
29.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster) 		PF00209
(SNF) 		6 ASP A  46
VAL A 120
TYR A 124
GLY A 322
SER A 421
GLY A 425
 41U  A 605 ( 3.3A)
41U  A 605 (-4.2A)
41U  A 605 ( 3.8A)
41U  A 605 ( 4.1A)
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
 0.58A 4mmbA-4xnuA:
40.9		 4mmbA-4xnuA:
29.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3h PROTEIN SCARECROW

(Arabidopsis
thaliana) 		PF03514
(GRAS) 		5 VAL A 517
ALA A 648
GLY A 599
PHE A 600
GLY A 602
 None
 1.12A 4mmbA-5b3hA:
undetectable		 4mmbA-5b3hA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epg ALDEHYDE OXIDASE

(Homo sapiens) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 ASP A1093
VAL A1163
TYR A1161
SER A1265
GLY A1192
 None
 1.08A 4mmbA-5epgA:
undetectable		 4mmbA-5epgA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f83 BETA-LACTAMASE

(Pseudomonas
aeruginosa) 		PF13354
(Beta-lactamase2) 		5 PRO A  69
ALA A  71
GLY A  63
PHE A  66
SER A 125
 None
None
IM2  A 301 ( 3.9A)
None
IM2  A 301 (-2.7A)
 1.29A 4mmbA-5f83A:
0.4		 4mmbA-5f83A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ham RICKCE

(Rickettsia
bellii) 		no annotation 5 ASP A 624
GLY A 656
PHE A 631
SER A 626
GLY A 629
 None
 1.03A 4mmbA-5hamA:
undetectable		 4mmbA-5hamA:
20.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i6z SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER

(Homo sapiens) 		PF00209
(SNF) 		6 ASP A  98
ALA A 173
TYR A 176
GLY A 338
SER A 438
GLY A 442
 None
 0.78A 4mmbA-5i6zA:
41.9		 4mmbA-5i6zA:
31.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jrl DIPEPTIDYL
AMINOPEPTIDASES/ACYL
AMINOACYL-PEPTIDASES
-LIKE PROTEIN

(Sphingopyxis
alaskensis) 		PF00326
(Peptidase_S9) 		5 ASP A 691
VAL A 490
ALA A 456
TYR A 488
GLY A 554
 None
 1.12A 4mmbA-5jrlA:
undetectable		 4mmbA-5jrlA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1c WD REPEAT-CONTAINING
PROTEIN 20

(Homo sapiens) 		PF00400
(WD40) 		5 ASP C 382
VAL C 288
ALA C 298
GLY C 370
GLY C 300
 None
 1.28A 4mmbA-5k1cC:
undetectable		 4mmbA-5k1cC:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5khn RND TRANSPORTER

(Burkholderia
multivorans) 		no annotation 5 VAL B 385
ALA B 384
GLY B 404
PHE B 389
SER B 391
 None
 1.35A 4mmbA-5khnB:
undetectable		 4mmbA-5khnB:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5koi ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]

(Brucella
abortus) 		PF13561
(adh_short_C2) 		5 VAL A 185
ALA A 175
TYR A 178
GLY A 139
GLY A 179
 None
 1.30A 4mmbA-5koiA:
undetectable		 4mmbA-5koiA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m2n ELONGATOR COMPLEX
PROTEIN 2

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		5 ASP A 777
VAL A  51
GLY A  35
SER A 779
GLY A 383
 None
 1.33A 4mmbA-5m2nA:
undetectable		 4mmbA-5m2nA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t6o POLY-BETA-HYDROXYBUT
ERATE POLYMERASE

(Cupriavidus
necator) 		PF07167
(PhaC_N) 		5 ASP A 254
PRO A 579
ALA A 215
TYR A 228
GLY A 206
 None
 1.26A 4mmbA-5t6oA:
undetectable		 4mmbA-5t6oA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8t S-ADENOSYLMETHIONINE
SYNTHASE

(Neisseria
gonorrhoeae) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		5 ASP A 243
VAL A  11
ALA A 167
GLY A 245
GLY A  14
 None
 1.33A 4mmbA-5t8tA:
undetectable		 4mmbA-5t8tA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8t S-ADENOSYLMETHIONINE
SYNTHASE

(Neisseria
gonorrhoeae) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		5 PRO A  16
VAL A  19
ALA A  20
GLY A  49
GLY A 245
 None
 1.27A 4mmbA-5t8tA:
undetectable		 4mmbA-5t8tA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8t S-ADENOSYLMETHIONINE
SYNTHASE

(Neisseria
gonorrhoeae) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		5 PRO A  16
VAL A  19
ALA A  20
GLY A  49
PHE A  85
 None
 1.24A 4mmbA-5t8tA:
undetectable		 4mmbA-5t8tA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqz GLUCAN-BINDING
PROTEIN C, GBPC

(Streptococcus
mutans) 		no annotation 5 PRO A 461
TYR A 423
GLY A 426
SER A 376
GLY A 374
 None
 1.23A 4mmbA-5uqzA:
undetectable		 4mmbA-5uqzA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wab PUTATIVE
BETA-GLUCOSIDASE

(Bifidobacterium
adolescentis) 		no annotation 5 VAL A 102
ALA A 103
GLY A  45
SER A 151
GLY A 149
 None
 1.25A 4mmbA-5wabA:
undetectable		 4mmbA-5wabA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5weo GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF00822
(PMP22_Claudin)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 VAL A 530
ALA A 532
TYR A 533
SER A 537
GLY A 535
 None
 1.27A 4mmbA-5weoA:
undetectable		 4mmbA-5weoA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wi9 -

(-) 		no annotation 5 PRO A 242
VAL A 245
ALA A 246
TYR A 250
GLY A 270
 None
 1.15A 4mmbA-5wi9A:
undetectable		 4mmbA-5wi9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yy8 INFLUENZA VIRUS
NS1A-BINDING PROTEIN

(Homo sapiens) 		no annotation 5 ASP A 115
PRO A  90
GLY A 108
SER A 113
GLY A 111
 None
 1.34A 4mmbA-5yy8A:
undetectable		 4mmbA-5yy8A:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zby HYDROGENASE
MATURATION PROTEASE
HYCI

(Thermococcus
kodakarensis) 		no annotation 5 VAL A  33
ALA A  34
GLY A 124
PHE A  29
GLY A  18
 None
 1.01A 4mmbA-5zbyA:
undetectable		 4mmbA-5zbyA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en9 HYDROGENASE-2 SMALL
CHAIN

(Escherichia
coli) 		no annotation 5 VAL S 126
ALA S 127
GLY S 153
SER S 121
GLY S 124
 None
 1.34A 4mmbA-6en9S:
undetectable		 4mmbA-6en9S:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eu6 AMMONIUM TRANSPORTER

(Candidatus
Kuenenia
stuttgartiensis) 		no annotation 5 PRO A 319
ALA A 322
GLY A  33
PHE A  34
GLY A 113
 None
 0.91A 4mmbA-6eu6A:
undetectable		 4mmbA-6eu6A:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f39 COMPLEMENT C1R
SUBCOMPONENT

(Homo sapiens) 		no annotation 5 ASP A 226
TYR A 197
GLY A 252
PHE A 223
SER A 278
 CA  A 303 (-3.2A)
None
None
None
CA  A 303 ( 3.8A)
 1.14A 4mmbA-6f39A:
undetectable		 4mmbA-6f39A:
9.43