SIMILAR PATTERNS OF AMINO ACIDS FOR 4MMA_A_CXXA603

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpt CYTOCHROME P450-TERP

(Pseudomonas sp.) 		PF00067
(p450) 		5 ASP A 270
ALA A 307
SER A 273
SER A 276
GLY A 277
 None
 1.29A 4mmaA-1cptA:
0.0		 4mmaA-1cptA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3d [NIFE] HYDROGENASE
LARGE SUBUNIT

(Desulfovibrio
desulfuricans) 		PF00374
(NiFeSe_Hases) 		5 TYR B 180
ASP B 125
PRO B 520
VAL B 517
ALA B 518
 None
 1.17A 4mmaA-1e3dB:
0.0		 4mmaA-1e3dB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehl ANTI-(6-4)
PHOTOPRODUCT
ANTIBODY 64M-2 FAB
(HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 PRO H  14
VAL H 111
ALA H  12
SER H  82
SER H  17
 None
 1.22A 4mmaA-1ehlH:
undetectable		 4mmaA-1ehlH:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz7 LIPASE 2

(Diutina rugosa) 		PF00135
(COesterase) 		5 PRO A  65
VAL A 296
ALA A 298
PHE A  87
GLY A  67
 None
None
NAG  A1536 ( 4.6A)
None
None
 1.22A 4mmaA-1gz7A:
0.1		 4mmaA-1gz7A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzj EGI

(Thermoascus
aurantiacus) 		PF00150
(Cellulase) 		5 ASP A 129
VAL A 116
ALA A 117
PHE A 112
GLY A 152
 None
 1.26A 4mmaA-1gzjA:
undetectable		 4mmaA-1gzjA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iyx ENOLASE

(Enterococcus
hirae) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 ASP A  85
VAL A  24
ALA A 116
SER A 114
THR A  26
 None
 1.24A 4mmaA-1iyxA:
undetectable		 4mmaA-1iyxA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lxy ARGININE DEIMINASE

(Mycoplasma
arginini) 		PF02274
(Amidinotransf) 		5 ASP A  69
PRO A 358
VAL A 360
ALA A 355
GLY A  18
 None
 1.13A 4mmaA-1lxyA:
undetectable		 4mmaA-1lxyA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mam IGG2B-KAPPA YST9.1
FAB (HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 PRO H 129
VAL H 127
SER H 185
SER H 184
THR H 211
 None
 1.31A 4mmaA-1mamH:
undetectable		 4mmaA-1mamH:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r24 PROTEIN (IGG3-KAPPA
ANTIBODY (HEAVY
CHAIN))

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 PRO B 132
VAL B 130
SER B 188
SER B 187
GLY B 148
 None
 1.31A 4mmaA-1r24B:
undetectable		 4mmaA-1r24B:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rxw FLAP
STRUCTURE-SPECIFIC
ENDONUCLEASE

(Archaeoglobus
fulgidus) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		5 ASP A  27
ALA A 161
SER A 175
SER A 180
GLY A 179
 None
 1.27A 4mmaA-1rxwA:
0.0		 4mmaA-1rxwA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0t INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE

(Mycobacterium
tuberculosis) 		PF01513
(NAD_kinase) 		5 ASP A 189
ALA A 203
TYR A 202
SER A 205
GLY A 207
 None
 1.25A 4mmaA-1u0tA:
undetectable		 4mmaA-1u0tA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhk HYPOTHETICAL PROTEIN
YQEU

(Bacillus
subtilis) 		PF04452
(Methyltrans_RNA) 		5 VAL A 172
ALA A 173
TYR A 174
GLY A 226
THR A 218
 None
 1.29A 4mmaA-1vhkA:
0.5		 4mmaA-1vhkA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfc ALANINE RACEMASE

(Mycobacterium
tuberculosis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 ASP A 115
VAL A 130
ALA A 107
SER A 110
SER A 109
 None
 1.11A 4mmaA-1xfcA:
undetectable		 4mmaA-1xfcA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y0l CATALYTIC ANTIBODY
FAB 34E4 HEAVY CHAIN

(Homo sapiens;
Mus musculus) 		no annotation 5 PRO H  14
VAL H 111
ALA H  12
SER H  82
GLY H  16
 None
 1.30A 4mmaA-1y0lH:
undetectable		 4mmaA-1y0lH:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ydw AX110P-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF01408
(GFO_IDH_MocA) 		5 VAL A  36
ALA A  37
SER A  40
GLY A  61
THR A  57
 None
 1.23A 4mmaA-1ydwA:
undetectable		 4mmaA-1ydwA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z0u PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE

(Archaeoglobus
fulgidus) 		PF01513
(NAD_kinase) 		5 ASP A 145
ALA A 159
TYR A 158
SER A 161
GLY A 163
 None
None
NAP  A3076 (-3.4A)
NAP  A3076 (-2.3A)
None
 1.27A 4mmaA-1z0uA:
undetectable		 4mmaA-1z0uA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cdp BETA-AGARASE 1

(Saccharophagus
degradans) 		PF03422
(CBM_6) 		5 TYR A  63
VAL A 108
PHE A  76
SER A  62
GLY A 105
 None
CL  A1144 ( 4.2A)
None
None
EDO  A1141 (-4.0A)
 1.04A 4mmaA-2cdpA:
undetectable		 4mmaA-2cdpA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e9y CARBAMATE KINASE

(Aeropyrum
pernix) 		PF00696
(AA_kinase) 		5 ASP A 217
VAL A 313
ALA A 258
SER A 284
THR A 311
 None
 1.31A 4mmaA-2e9yA:
undetectable		 4mmaA-2e9yA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ecf DIPEPTIDYL PEPTIDASE
IV

(Stenotrophomonas
maltophilia) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		5 TYR A 614
VAL A 523
TYR A 524
SER A 610
GLY A 613
 None
 1.28A 4mmaA-2ecfA:
undetectable		 4mmaA-2ecfA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f96 RIBONUCLEASE T

(Pseudomonas
aeruginosa) 		PF00929
(RNase_T) 		5 VAL A  36
PHE A 140
SER A 135
SER A 134
THR A  38
 None
 1.29A 4mmaA-2f96A:
undetectable		 4mmaA-2f96A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fp7 GENOME POLYPROTEIN

(West Nile virus) 		PF00949
(Peptidase_S7) 		5 ASP B 129
VAL B  99
TYR B 150
SER B 135
GLY B 133
 None
 1.20A 4mmaA-2fp7B:
undetectable		 4mmaA-2fp7B:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i05 DNA REPLICATION
TERMINUS
SITE-BINDING PROTEIN

(Escherichia
coli) 		PF05472
(Ter) 		5 ASP A 281
PRO A 238
VAL A 236
ALA A 173
GLY A 171
 None
 1.08A 4mmaA-2i05A:
undetectable		 4mmaA-2i05A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iik 3-KETOACYL-COA
THIOLASE,
PEROXISOMAL

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 VAL A 130
ALA A 129
SER A 124
SER A 125
GLY A 384
 None
 1.32A 4mmaA-2iikA:
undetectable		 4mmaA-2iikA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lj8 COFILIN/ACTIN
DEPOLYMERIZING
FACTOR, PUTATIVE

(Trypanosoma
brucei) 		PF00241
(Cofilin_ADF) 		5 TYR A 106
VAL A 114
ALA A 112
SER A 107
SER A 108
 None
 1.22A 4mmaA-2lj8A:
undetectable		 4mmaA-2lj8A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m2j PUTATIVE PERIPLASMIC
PROTEIN

(Salmonella
enterica) 		PF07338
(DUF1471) 		5 ASP A  51
VAL A  70
SER A  54
SER A  57
THR A  73
 None
 1.27A 4mmaA-2m2jA:
undetectable		 4mmaA-2m2jA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q0l THIOREDOXIN
REDUCTASE

(Helicobacter
pylori) 		PF07992
(Pyr_redox_2) 		5 ALA A  20
TYR A  19
PHE A  72
SER A  15
GLY A  17
 None
 1.19A 4mmaA-2q0lA:
undetectable		 4mmaA-2q0lA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 VAL A 207
ALA A 208
SER A 197
GLY A 152
THR A 447
 None
 1.17A 4mmaA-2qo3A:
undetectable		 4mmaA-2qo3A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vx4 CELLVIBRIO JAPONICUS
MANNANASE CJMAN26C

(Cellvibrio
japonicus) 		PF02156
(Glyco_hydro_26) 		5 TYR A 418
VAL A 113
ALA A 112
GLY A 148
THR A 152
 None
 1.26A 4mmaA-2vx4A:
undetectable		 4mmaA-2vx4A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww2 ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		PF07971
(Glyco_hydro_92) 		5 ASP A  97
PRO A 198
PHE A 201
SER A 393
GLY A 395
 None
 1.15A 4mmaA-2ww2A:
undetectable		 4mmaA-2ww2A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7x SENSOR PROTEIN

(Bacteroides
thetaiotaomicron) 		PF13407
(Peripla_BP_4) 		5 ASP A 266
VAL A 143
TYR A 146
SER A 150
SER A 149
 K  A1336 ( 4.2A)
None
None
None
None
 0.86A 4mmaA-2x7xA:
undetectable		 4mmaA-2x7xA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xpz LEUKOTRIENE A-4
HYDROLASE

(Saccharomyces
cerevisiae) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		5 ASP A 198
VAL A  69
PHE A  91
SER A  62
THR A  72
 None
 1.28A 4mmaA-2xpzA:
undetectable		 4mmaA-2xpzA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yun NOSTRIN

(Homo sapiens) 		PF14604
(SH3_9) 		5 PRO A  55
VAL A  59
ALA A  57
PHE A  54
GLY A  41
 None
 1.31A 4mmaA-2yunA:
undetectable		 4mmaA-2yunA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8z LIPASE

(Pseudomonas sp.
MIS38) 		PF00353
(HemolysinCabind) 		5 ALA A 237
TYR A 236
SER A 204
GLY A 210
THR A 282
 None
 1.10A 4mmaA-2z8zA:
1.1		 4mmaA-2z8zA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3das PUTATIVE
OXIDOREDUCTASE

(Streptomyces
coelicolor) 		PF07995
(GSDH) 		5 VAL A  71
ALA A  53
SER A 103
SER A  75
GLY A  81
 None
 1.26A 4mmaA-3dasA:
undetectable		 4mmaA-3dasA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e60 3-OXOACYL-[ACYL-CARR
IER-PROTEIN ]
SYNTHASE II

(Bartonella
henselae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ASP A 231
VAL A 319
ALA A 317
SER A 314
GLY A 312
 None
 1.30A 4mmaA-3e60A:
undetectable		 4mmaA-3e60A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		5 TYR A 191
ASP A 148
VAL A 132
SER A 209
GLY A 211
 None
 1.14A 4mmaA-3f3zA:
undetectable		 4mmaA-3f3zA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fys PROTEIN DEGV

(Bacillus
subtilis) 		PF02645
(DegV) 		5 PRO A 226
VAL A 254
TYR A 251
SER A 222
GLY A 224
 None
 0.98A 4mmaA-3fysA:
undetectable		 4mmaA-3fysA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3w PHOSPHOGLUCOSAMINE
MUTASE

(Francisella
tularensis) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 VAL A  44
ALA A  92
PHE A  96
SER A 114
SER A 115
 None
 1.29A 4mmaA-3i3wA:
undetectable		 4mmaA-3i3wA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kom TRANSKETOLASE

(Francisella
tularensis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 TYR A 408
PRO A 430
PHE A 376
SER A 379
GLY A 432
 None
 1.25A 4mmaA-3komA:
undetectable		 4mmaA-3komA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8q CELLULOSOMAL
SCAFFOLDIN ADAPTOR
PROTEIN B

(Acetivibrio
cellulolyticus) 		PF00963
(Cohesin) 		5 ASP A  12
PRO A  64
ALA A  66
SER A  25
THR A  52
 None
 1.25A 4mmaA-3l8qA:
undetectable		 4mmaA-3l8qA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lq1 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE-1-CARBOXYLA
TE SYNTHASE

(Listeria
monocytogenes) 		PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
PF16582
(TPP_enzyme_M_2) 		5 ASP A  53
VAL A 448
ALA A 446
SER A 441
SER A 442
 None
 1.18A 4mmaA-3lq1A:
undetectable		 4mmaA-3lq1A:
21.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mpn TRANSPORTER

(Aquifex
aeolicus) 		PF00209
(SNF) 		7 PRO A 101
VAL A 104
ALA A 105
TYR A 108
PHE A 259
SER A 355
SER A 356
 None
None
None
LEU  A 601 (-4.5A)
LEU  A 601 (-3.6A)
NA  A 751 ( 2.3A)
None
 0.62A 4mmaA-3mpnA:
59.6		 4mmaA-3mpnA:
97.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3msv NUCLEAR IMPORT
ADAPTOR, NRO1

(Schizosaccharomyces
pombe) 		PF12753
(Nro1) 		5 TYR A 120
VAL A 127
ALA A 126
SER A 121
SER A 122
 None
 1.14A 4mmaA-3msvA:
undetectable		 4mmaA-3msvA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nks PROTOPORPHYRINOGEN
OXIDASE

(Homo sapiens) 		PF01593
(Amino_oxidase) 		5 VAL A 316
ALA A 315
SER A 313
GLY A 370
THR A 366
 None
 1.31A 4mmaA-3nksA:
1.2		 4mmaA-3nksA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nre ALDOSE 1-EPIMERASE

(Escherichia
coli) 		PF01263
(Aldose_epim) 		5 ASP A  44
PRO A  49
PHE A  48
SER A  16
GLY A  19
 None
 1.31A 4mmaA-3nreA:
undetectable		 4mmaA-3nreA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd5 PUTATIVE
RIBOSE-5-PHOSPHATE
ISOMERASE

(Coccidioides
immitis) 		PF02502
(LacAB_rpiB) 		5 PRO A  54
VAL A  56
ALA A  57
GLY A  81
THR A  51
 IOD  A 174 ( 4.4A)
None
None
CSO  A  76 (-3.4A)
None
 1.21A 4mmaA-3qd5A:
undetectable		 4mmaA-3qd5A:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r2g INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE

(Legionella
pneumophila) 		PF00478
(IMPDH) 		5 PRO A  44
ALA A  67
PHE A 224
SER A  47
THR A  40
 None
 1.30A 4mmaA-3r2gA:
undetectable		 4mmaA-3r2gA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9u THIOREDOXIN
REDUCTASE

(Campylobacter
jejuni) 		PF07992
(Pyr_redox_2) 		5 ALA A  20
TYR A  19
PHE A  72
SER A  15
GLY A  17
 None
 1.25A 4mmaA-3r9uA:
undetectable		 4mmaA-3r9uA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3scy HYPOTHETICAL
BACTERIAL
6-PHOSPHOGLUCONOLACT
ONASE

(Bacteroides
fragilis) 		PF10282
(Lactonase) 		5 VAL A 307
ALA A 308
TYR A 297
GLY A 323
THR A 327
 None
 1.26A 4mmaA-3scyA:
undetectable		 4mmaA-3scyA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t7b ACETYLGLUTAMATE
KINASE

(Yersinia pestis) 		PF00696
(AA_kinase) 		5 PRO A 230
VAL A 231
ALA A 224
SER A 226
GLY A 228
 None
 1.27A 4mmaA-3t7bA:
undetectable		 4mmaA-3t7bA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umg HALOACID
DEHALOGENASE

(Rhodococcus
jostii) 		PF00702
(Hydrolase) 		5 ASP A 198
PRO A 186
VAL A 189
GLY A 206
THR A 178
 None
 1.27A 4mmaA-3umgA:
undetectable		 4mmaA-3umgA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vb0 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Sphingomonas
wittichii) 		PF00903
(Glyoxalase) 		5 ASP A 111
VAL A 193
ALA A 194
PHE A 162
SER A 196
 None
 1.19A 4mmaA-3vb0A:
undetectable		 4mmaA-3vb0A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btp P1

(Pseudomonas
phage phi8) 		no annotation 6 PRO A 650
VAL A 636
ALA A 648
TYR A 638
GLY A 725
THR A 746
 None
 1.24A 4mmaA-4btpA:
1.8		 4mmaA-4btpA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7g BETA-N-ACETYLHEXOSAM
INIDASE

(Streptomyces
coelicolor) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b) 		5 TYR A 161
PRO A 449
VAL A 451
ALA A 452
THR A 380
 None
 1.19A 4mmaA-4c7gA:
undetectable		 4mmaA-4c7gA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dqv PROBABLE PEPTIDE
SYNTHETASE NRP
(PEPTIDE SYNTHASE)

(Mycobacterium
tuberculosis) 		PF07993
(NAD_binding_4) 		5 ASP A  27
PRO A 168
VAL A 170
ALA A 171
PHE A 166
 None
 1.26A 4mmaA-4dqvA:
undetectable		 4mmaA-4dqvA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dt5 ANTIFREEZE PROTEIN

(Rhagium
inquisitor) 		no annotation 5 ALA A  44
SER A  36
SER A  42
GLY A  34
THR A  15
 None
 1.31A 4mmaA-4dt5A:
undetectable		 4mmaA-4dt5A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eud SUCCINYL-COA:ACETATE
COENZYME A
TRANSFERASE

(Acetobacter
aceti) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		5 ASP A 391
PRO A 265
SER A 395
SER A 396
GLY A 356
 None
 1.27A 4mmaA-4eudA:
undetectable		 4mmaA-4eudA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewj ENOLASE 2

(Streptococcus
suis) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 ASP A  86
VAL A  25
ALA A 117
SER A 115
THR A  27
 None
 1.30A 4mmaA-4ewjA:
undetectable		 4mmaA-4ewjA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g25 PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL

(Arabidopsis
thaliana) 		PF16953
(PRORP)
PF17177
(PPR_long) 		5 ASP A 197
VAL A 233
PHE A 221
SER A 213
GLY A 215
 None
 1.26A 4mmaA-4g25A:
undetectable		 4mmaA-4g25A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g59 M152 PROTEIN

(Murid
betaherpesvirus
1) 		PF11624
(M157) 		5 TYR C  82
ASP C 142
VAL C 126
GLY C 149
THR C 128
 None
 1.26A 4mmaA-4g59C:
undetectable		 4mmaA-4g59C:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfi MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ASP A 298
VAL A 286
ALA A 283
SER A 279
GLY A 281
 ALA  A 402 (-3.0A)
None
None
None
None
 1.26A 4mmaA-4gfiA:
undetectable		 4mmaA-4gfiA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mks ENOLASE 2

(Lactobacillus
gasseri) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 ASP A  86
VAL A  25
ALA A 117
SER A 115
THR A  27
 None
 1.31A 4mmaA-4mksA:
undetectable		 4mmaA-4mksA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nwb MRNA TURNOVER
PROTEIN 4

(Chaetomium
thermophilum) 		PF00466
(Ribosomal_L10) 		5 ALA A  86
SER A 228
SER A 229
GLY A 232
THR A  93
 None
 1.28A 4mmaA-4nwbA:
undetectable		 4mmaA-4nwbA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ogq APOCYTOCHROME F

(Nostoc sp. PCC
7120) 		PF01333
(Apocytochr_F_C)
PF16639
(Apocytochr_F_N) 		5 ASP C 198
VAL C 225
ALA C 224
SER C 181
GLY C 222
 None
 1.23A 4mmaA-4ogqC:
undetectable		 4mmaA-4ogqC:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ope NRPS/PKS

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 ALA A4638
SER A4571
SER A4395
GLY A4574
THR A4530
 None
 1.28A 4mmaA-4opeA:
undetectable		 4mmaA-4opeA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqj PKS

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 VAL A 195
ALA A 196
SER A 185
GLY A 134
THR A 438
 None
 1.22A 4mmaA-4oqjA:
undetectable		 4mmaA-4oqjA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qgs ALCOHOL
DEHYDROGENASE YQHD

(Escherichia
coli) 		PF00465
(Fe-ADH) 		5 ASP A 227
PRO A 185
VAL A 188
ALA A 189
THR A 180
 None
 0.99A 4mmaA-4qgsA:
undetectable		 4mmaA-4qgsA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wky BETA-KETOACYL
SYNTHASE

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 VAL A 195
ALA A 196
SER A 185
GLY A 134
THR A 435
 None
 1.19A 4mmaA-4wkyA:
undetectable		 4mmaA-4wkyA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xcm CELL WALL-BINDING
ENDOPEPTIDASE-RELATE
D PROTEIN

(Thermus
thermophilus) 		PF00877
(NLPC_P60)
PF01476
(LysM) 		5 PRO A 142
VAL A 224
ALA A 217
SER A 219
GLY A 221
 None
 1.19A 4mmaA-4xcmA:
undetectable		 4mmaA-4xcmA:
20.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster) 		PF00209
(SNF) 		5 TYR A 124
PHE A 325
SER A 421
SER A 422
GLY A 424
 41U  A 605 ( 3.8A)
41U  A 605 ( 4.7A)
NA  A 602 ( 2.4A)
None
None
 1.25A 4mmaA-4xnuA:
40.1		 4mmaA-4xnuA:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster) 		PF00209
(SNF) 		5 TYR A 124
PHE A 325
SER A 421
SER A 422
GLY A 425
 41U  A 605 ( 3.8A)
41U  A 605 ( 4.7A)
NA  A 602 ( 2.4A)
None
41U  A 605 ( 3.7A)
 0.88A 4mmaA-4xnuA:
40.1		 4mmaA-4xnuA:
30.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvm DNA POLYMERASE NU

(Homo sapiens) 		PF00476
(DNA_pol_A) 		5 ASP A 623
VAL A 821
ALA A 818
PHE A 807
SER A 847
 None
 1.21A 4mmaA-4xvmA:
undetectable		 4mmaA-4xvmA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE

(Acidovorax sp.
MR-S7) 		PF01804
(Penicil_amidase) 		5 ALA C  65
SER C 173
SER C  63
GLY C 196
THR C 192
 None
 1.06A 4mmaA-4yfaC:
undetectable		 4mmaA-4yfaC:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z42 UREASE SUBUNIT ALPHA
UREASE SUBUNIT BETA

(Yersinia
enterocolitica) 		PF00449
(Urease_alpha)
PF00699
(Urease_beta)
PF01979
(Amidohydro_1) 		5 ASP C  53
PRO C 105
VAL C 107
GLY C 103
THR B 123
 None
 1.31A 4mmaA-4z42C:
0.0		 4mmaA-4z42C:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aid MEP2

(Candida
albicans) 		PF00909
(Ammonium_transp) 		5 ASP A 180
VAL A 304
ALA A 358
TYR A 303
GLY A 372
 None
 1.08A 4mmaA-5aidA:
undetectable		 4mmaA-5aidA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5boe ENOLASE

(Staphylococcus
aureus) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 ASP A  88
VAL A  25
ALA A 119
SER A 117
THR A  27
 None
 1.29A 4mmaA-5boeA:
undetectable		 4mmaA-5boeA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c9i PROTEIN RELATED TO
PENICILLIN ACYLASE

(Acidovorax sp.
MR-S7) 		PF01804
(Penicil_amidase) 		5 ALA A 267
SER A 375
SER A 265
GLY A 398
THR A 394
 None
 1.01A 4mmaA-5c9iA:
undetectable		 4mmaA-5c9iA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cfa BONE
SIALOPROTEIN-BINDING
PROTEIN

(Staphylococcus
aureus) 		PF10425
(SdrG_C_C) 		5 ALA A 307
TYR A 306
SER A 304
SER A 305
THR A 192
 None
 1.10A 4mmaA-5cfaA:
undetectable		 4mmaA-5cfaA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5che GLUTAMYL-TRNA
REDUCTASE-BINDING
PROTEIN,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF10615
(DUF2470) 		5 PRO C 101
VAL C  95
ALA C  94
SER C  72
SER C  73
 None
 1.09A 4mmaA-5cheC:
undetectable		 4mmaA-5cheC:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwu NUCLEOPORIN NUP188

(Chaetomium
thermophilum) 		no annotation 5 VAL A1467
ALA A1466
PHE A1479
SER A1461
SER A1462
 None
 1.09A 4mmaA-5cwuA:
undetectable		 4mmaA-5cwuA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej3 ENDO-1,4-BETA-XYLANA
SE B

(Streptomyces
lividans) 		PF00457
(Glyco_hydro_11) 		5 VAL A 189
TYR A  37
SER A 185
SER A 186
GLY A  65
 None
 1.20A 4mmaA-5ej3A:
undetectable		 4mmaA-5ej3A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h71 ALGQ2

(Sphingomonas
sp.) 		PF01547
(SBP_bac_1) 		5 ASP A 343
PRO A  30
ALA A  32
SER A 345
GLY A 382
 None
 1.13A 4mmaA-5h71A:
undetectable		 4mmaA-5h71A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ha5 BRUCELLA OVIS
OXIDOREDUCTASE

(Brucella ovis) 		PF13561
(adh_short_C2) 		5 VAL A 151
ALA A 152
PHE A 214
SER A 156
GLY A 158
 None
 1.06A 4mmaA-5ha5A:
undetectable		 4mmaA-5ha5A:
20.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i6z SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER

(Homo sapiens) 		PF00209
(SNF) 		6 TYR A  95
ALA A 173
TYR A 176
SER A 438
GLY A 442
THR A 497
 None
 0.72A 4mmaA-5i6zA:
41.4		 4mmaA-5i6zA:
32.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i6z SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER

(Homo sapiens) 		PF00209
(SNF) 		6 TYR A  95
ASP A  98
ALA A 173
TYR A 176
GLY A 442
THR A 497
 None
 0.97A 4mmaA-5i6zA:
41.4		 4mmaA-5i6zA:
32.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i6z SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER

(Homo sapiens) 		PF00209
(SNF) 		5 TYR A  95
ASP A  98
TYR A 176
SER A 439
GLY A 442
 None
 0.93A 4mmaA-5i6zA:
41.4		 4mmaA-5i6zA:
32.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i6z SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER

(Homo sapiens) 		PF00209
(SNF) 		5 TYR A  95
TYR A 176
SER A 438
SER A 439
GLY A 442
 None
 0.83A 4mmaA-5i6zA:
41.4		 4mmaA-5i6zA:
32.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l7v GLYCOSIDE HYDROLASE

(Bacteroides
vulgatus) 		PF13320
(DUF4091) 		5 TYR A 491
VAL A 130
ALA A 131
SER A 497
THR A 106
 None
 1.18A 4mmaA-5l7vA:
undetectable		 4mmaA-5l7vA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n8p S-LAYER PROTEIN

(Caulobacter
vibrioides) 		PF00353
(HemolysinCabind) 		5 VAL A 408
ALA A 409
SER A 412
SER A 411
THR A 392
 None
 1.23A 4mmaA-5n8pA:
undetectable		 4mmaA-5n8pA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n97 S-LAYER PROTEIN RSAA

(Caulobacter
vibrioides) 		PF00353
(HemolysinCabind) 		5 VAL A 408
ALA A 409
SER A 412
SER A 411
THR A 392
 None
 1.22A 4mmaA-5n97A:
undetectable		 4mmaA-5n97A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nns GLYCOSYL HYDROLASE
FAMILY 61, 2 PROTEIN

(Heterobasidion
irregulare) 		no annotation 5 VAL A 175
ALA A  66
SER A 143
SER A 142
GLY A 178
 None
 1.17A 4mmaA-5nnsA:
undetectable		 4mmaA-5nnsA:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szn PROTOCADHERIN GAMMA
A9

(Mus musculus) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		5 TYR A 187
VAL A 183
ALA A 198
SER A 195
SER A 196
 MAN  A 601 (-4.7A)
None
None
MAN  A 601 (-1.4A)
None
 0.97A 4mmaA-5sznA:
undetectable		 4mmaA-5sznA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5usd PEPTIDASE S66

(Bacillus
anthracis) 		PF02016
(Peptidase_S66) 		5 ALA A 293
TYR A 188
PHE A 226
SER A 296
GLY A 263
 None
 0.99A 4mmaA-5usdA:
undetectable		 4mmaA-5usdA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vrb TRANSKETOLASE

(Neisseria
gonorrhoeae) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 PRO A 426
VAL A 373
TYR A 401
SER A 376
GLY A 428
 None
 1.18A 4mmaA-5vrbA:
undetectable		 4mmaA-5vrbA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wan PYRIMIDINE
MONOOXYGENASE RUTA

(Escherichia
coli) 		PF00296
(Bac_luciferase) 		5 VAL A 319
ALA A 320
PHE A 242
SER A 238
GLY A 327
 None
 1.08A 4mmaA-5wanA:
undetectable		 4mmaA-5wanA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5weo GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF00822
(PMP22_Claudin)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 VAL A 530
ALA A 532
TYR A 533
SER A 537
GLY A 535
 None
 1.21A 4mmaA-5weoA:
2.7		 4mmaA-5weoA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wi9 -

(-) 		no annotation 5 PRO A 242
VAL A 245
ALA A 246
TYR A 250
GLY A 270
 None
 1.18A 4mmaA-5wi9A:
0.7		 4mmaA-5wi9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bpd MONOCLONAL ANTIBODY
10B12 FAB HEAVY
CHAIN

(Mus musculus) 		no annotation 5 VAL A 136
ALA A  31
SER A 103
SER A  36
GLY A  34
 None
 1.32A 4mmaA-6bpdA:
undetectable		 4mmaA-6bpdA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ch0 -

(-) 		no annotation 5 ALA C 199
TYR C 239
SER C 196
GLY C 201
THR C 148
 None
 1.30A 4mmaA-6ch0C:
undetectable		 4mmaA-6ch0C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ehn CARBOHYDRATE
ESTERASE MZ0003

(unidentified
prokaryotic
organism) 		no annotation 5 PRO A  20
VAL A 350
ALA A 349
TYR A 351
GLY A 346
 None
 1.26A 4mmaA-6ehnA:
undetectable		 4mmaA-6ehnA:
9.49