SIMILAR PATTERNS OF AMINO ACIDS FOR 4MM9_A_FVXA603_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dbi | AK.1 SERINE PROTEASE (Bacillus sp.Ak1) |
PF00082(Peptidase_S8) | 5 | ASP A 48VAL A 211ALA A 220TYR A 219GLY A 92 | CA A 701 (-2.2A)NoneNoneNoneNone | 1.09A | 4mm9A-1dbiA:0.0 | 4mm9A-1dbiA:20.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ded | CYCLODEXTRINGLUCANOTRANSFERASE (Bacillus sp.1011) |
PF00128(Alpha-amylase)PF00686(CBM_20)PF01833(TIG)PF02806(Alpha-amylase_C) | 5 | ASP A 319GLY A 505SER A 279GLY A 277ASP A 577 | None | 1.29A | 4mm9A-1dedA:0.0 | 4mm9A-1dedA:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dxj | CLASS II CHITINASE (Canavaliaensiformis) |
PF00182(Glyco_hydro_19) | 5 | ASP A 213TYR A 221TYR A 81GLY A 71GLY A 79 | None | 1.27A | 4mm9A-1dxjA:undetectable | 4mm9A-1dxjA:19.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ezw | COENZYMEF420-DEPENDENTN5,N10-METHYLENETETRAHYDROMETHANOPTERINREDUCTASE (Methanopyruskandleri) |
PF00296(Bac_luciferase) | 5 | ASP A 225VAL A 195ALA A 177GLY A 318PHE A 203 | None | 1.22A | 4mm9A-1ezwA:undetectable | 4mm9A-1ezwA:22.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fi8 | ECOTINNATURAL KILLER CELLPROTEASE 1 (Escherichiacoli;Rattusnorvegicus) |
PF00089(Trypsin)PF03974(Ecotin) | 5 | ASP C 84VAL A 138GLY A 142SER A 195GLY A 197 | None | 1.14A | 4mm9A-1fi8C:undetectable | 4mm9A-1fi8C:10.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g33 | PARVALBUMIN ALPHA (Rattusnorvegicus) |
PF13499(EF-hand_7) | 5 | ASP A 42VAL A 106ALA A 107PHE A 102SER A 39 | None | 1.29A | 4mm9A-1g33A:undetectable | 4mm9A-1g33A:9.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gtm | GLUTAMATEDEHYDROGENASE (Pyrococcusfuriosus) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 5 | ALA A 194TYR A 196GLY A 185GLY A 346ASP A 234 | None | 1.18A | 4mm9A-1gtmA:0.3 | 4mm9A-1gtmA:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i36 | CONSERVEDHYPOTHETICAL PROTEINMTH1747 (Methanothermobacterthermautotrophicus) |
PF03807(F420_oxidored)PF09130(DUF1932) | 5 | ASP A 86VAL A 11ALA A 12SER A 62GLY A 7 | NoneNAP A1350 (-3.8A)NoneNoneNAP A1350 (-3.4A) | 1.11A | 4mm9A-1i36A:0.5 | 4mm9A-1i36A:21.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lq2 | BETA-D-GLUCANGLUCOHYDROLASEISOENZYME EXO1 (Hordeum vulgare) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C) | 5 | VAL A 150ALA A 149GLY A 229GLY A 210ASP A 166 | None | 1.15A | 4mm9A-1lq2A:0.0 | 4mm9A-1lq2A:19.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m1j | FIBRINOGEN ALPHASUBUNITFIBRINOGEN BETACHAIN (Gallus gallus) |
PF00147(Fibrinogen_C)PF08702(Fib_alpha) | 5 | TYR B 421GLY B 263SER B 450GLY B 423ASP A 154 | None | 1.29A | 4mm9A-1m1jB:undetectable | 4mm9A-1m1jB:18.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qhk | PROTEIN(RIBONUCLEASE HI) (Saccharomycescerevisiae) |
PF01693(Cauli_VI) | 5 | VAL A 11ALA A 10TYR A 20TYR A 9GLY A 35 | None | 0.92A | 4mm9A-1qhkA:undetectable | 4mm9A-1qhkA:6.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tuh | HYPOTHETICAL PROTEINEGC068 (unculturedbacterium) |
PF12680(SnoaL_2) | 5 | TYR A 32VAL A 131GLY A 103GLY A 31ASP A 133 | None | 1.13A | 4mm9A-1tuhA:undetectable | 4mm9A-1tuhA:14.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1udx | THE GTP-BINDINGPROTEIN OBG (Thermusthermophilus) |
PF01018(GTP1_OBG)PF01926(MMR_HSR1)PF09269(DUF1967) | 5 | VAL A 20ALA A 19GLY A 32PHE A 22GLY A 73 | None | 1.08A | 4mm9A-1udxA:undetectable | 4mm9A-1udxA:22.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vrg | PROPIONYL-COACARBOXYLASE, BETASUBUNIT (Thermotogamaritima) |
PF01039(Carboxyl_trans) | 5 | VAL A 174ALA A 173TYR A 175GLY A 196GLY A 132 | NoneNoneNoneBCT A 517 (-3.7A)None | 1.20A | 4mm9A-1vrgA:0.0 | 4mm9A-1vrgA:23.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w0m | TRIOSEPHOSPHATEISOMERASE (Thermoproteustenax) |
PF00121(TIM)PF05690(ThiG) | 5 | VAL A 89ALA A 61TYR A 60GLY A 114GLY A 86 | None | 1.15A | 4mm9A-1w0mA:undetectable | 4mm9A-1w0mA:19.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w8o | BACTERIAL SIALIDASE (Micromonosporaviridifaciens) |
PF00754(F5_F8_type_C)PF10633(NPCBM_assoc)PF13088(BNR_2) | 5 | TYR A 296ASP A 291ALA A 250SER A 295ASP A 242 | NoneGOL A1652 (-4.9A)NoneNoneNone | 1.28A | 4mm9A-1w8oA:undetectable | 4mm9A-1w8oA:21.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wqa | PHOSPHO-SUGAR MUTASE (Pyrococcushorikoshii) |
PF00408(PGM_PMM_IV)PF02878(PGM_PMM_I)PF02879(PGM_PMM_II)PF02880(PGM_PMM_III) | 5 | VAL A 72GLY A 27SER A 67GLY A 69ASP A 74 | VAL A 72 ( 0.6A)GLY A 27 ( 0.0A)SER A 67 ( 0.0A)GLY A 69 ( 0.0A)ASP A 74 ( 0.6A) | 1.04A | 4mm9A-1wqaA:undetectable | 4mm9A-1wqaA:22.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xje | RIBONUCLEOTIDEREDUCTASE,B12-DEPENDENT (Thermotogamaritima) |
PF00317(Ribonuc_red_lgN)PF02867(Ribonuc_red_lgC) | 5 | ALA A 617TYR A 614GLY A 246PHE A 247GLY A 624 | None | 1.30A | 4mm9A-1xjeA:undetectable | 4mm9A-1xjeA:22.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xkq | SHORT-CHAINREDUCTASE FAMILYMEMBER (5D234) (Caenorhabditiselegans) |
PF13561(adh_short_C2) | 5 | ASP A 170VAL A 257ALA A 258GLY A 152SER A 147 | None | 1.30A | 4mm9A-1xkqA:undetectable | 4mm9A-1xkqA:20.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xny | PROPIONYL-COACARBOXYLASE COMPLEXB SUBUNIT (Streptomycescoelicolor) |
PF01039(Carboxyl_trans) | 5 | VAL A 185ALA A 184TYR A 186GLY A 207GLY A 143 | NoneNoneNoneNone1VU A5601 (-3.4A) | 1.15A | 4mm9A-1xnyA:undetectable | 4mm9A-1xnyA:21.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zak | ADENYLATE KINASE (Zea mays) |
PF00406(ADK) | 5 | ASP A 38GLY A 19SER A 35GLY A 91ASP A 160 | NoneAP5 A 223 (-3.6A)NoneAP5 A 223 (-4.9A)None | 1.10A | 4mm9A-1zakA:undetectable | 4mm9A-1zakA:17.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a9v | GMP SYNTHASE (Thermoplasmaacidophilum) |
PF00117(GATase) | 5 | ASP A 8VAL A 65TYR A 68SER A 49GLY A 82 | None | 1.16A | 4mm9A-2a9vA:undetectable | 4mm9A-2a9vA:16.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cdp | BETA-AGARASE 1 (Saccharophagusdegradans) |
PF03422(CBM_6) | 5 | TYR A 63VAL A 108PHE A 76SER A 62GLY A 105 | None CL A1144 ( 4.2A)NoneNoneEDO A1141 (-4.0A) | 1.13A | 4mm9A-2cdpA:undetectable | 4mm9A-2cdpA:14.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cfm | THERMOSTABLE DNALIGASE (Pyrococcusfuriosus) |
PF01068(DNA_ligase_A_M)PF04675(DNA_ligase_A_N)PF04679(DNA_ligase_A_C) | 5 | ALA A 151TYR A 3TYR A 153GLY A 160GLY A 91 | None | 1.29A | 4mm9A-2cfmA:undetectable | 4mm9A-2cfmA:23.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cy8 | D-PHENYLGLYCINEAMINOTRANSFERASE (Pseudomonasstutzeri) |
PF00202(Aminotran_3) | 5 | ASP A 201ALA A 231GLY A 138SER A 200GLY A 235 | None | 1.29A | 4mm9A-2cy8A:undetectable | 4mm9A-2cy8A:22.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f9y | ACETYL-COACARBOXYLASE,CARBOXYLTRANSFERASEALPHA CHAINACETYL-COENZYME ACARBOXYLASE CARBOXYLTRANSFERASE SUBUNITBETA (Escherichiacoli) |
PF01039(Carboxyl_trans)PF03255(ACCA) | 5 | ALA A 180TYR A 140GLY B 204PHE B 227SER B 209 | None | 1.23A | 4mm9A-2f9yA:undetectable | 4mm9A-2f9yA:20.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o6l | UDP-GLUCURONOSYLTRANSFERASE 2B7 (Homo sapiens) |
PF00201(UDPGT) | 5 | ASP A 435VAL A 413ALA A 412SER A 437GLY A 410 | None | 1.27A | 4mm9A-2o6lA:undetectable | 4mm9A-2o6lA:14.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vwb | PUTATIVEO-SIALOGLYCOPROTEINENDOPEPTIDASE (Methanocaldococcusjannaschii) |
PF00814(Peptidase_M22)PF01163(RIO1) | 5 | TYR A 221ALA A 227TYR A 190TYR A 226SER A 222 | None | 1.27A | 4mm9A-2vwbA:undetectable | 4mm9A-2vwbA:23.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zez | S-LAYER ASSOCIATEDMULTIDOMAINENDOGLUCANASE (Caldanaerobiuspolysaccharolyticus) |
PF02018(CBM_4_9) | 5 | ALA A 46PHE A 134SER A 130GLY A 42ASP A 77 | None | 1.25A | 4mm9A-2zezA:undetectable | 4mm9A-2zezA:14.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bf0 | PROTEASE 4 (Escherichiacoli) |
PF01343(Peptidase_S49) | 5 | TYR A 485VAL A 492ALA A 493GLY A 433PHE A 488 | None | 1.18A | 4mm9A-3bf0A:undetectable | 4mm9A-3bf0A:23.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ctd | PUTATIVE ATPASE, AAAFAMILY (Prochlorococcusmarinus) |
PF12002(MgsA_C)PF16193(AAA_assoc_2) | 5 | VAL A 318ALA A 340TYR A 343GLY A 308SER A 347 | None | 1.28A | 4mm9A-3ctdA:undetectable | 4mm9A-3ctdA:18.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dnf | 4-HYDROXY-3-METHYLBUT-2-ENYL DIPHOSPHATEREDUCTASE (Aquifexaeolicus) |
PF02401(LYTB) | 5 | VAL A 20ALA A 19GLY A 11PHE A 12GLY A 15 | NoneNoneNoneNoneF3S A2302 (-3.4A) | 1.20A | 4mm9A-3dnfA:undetectable | 4mm9A-3dnfA:20.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ec2 | DNA REPLICATIONPROTEIN DNAC (Aquifexaeolicus) |
PF01695(IstB_IS21) | 5 | ASP A 198TYR A 212GLY A 151SER A 201GLY A 204 | None | 1.25A | 4mm9A-3ec2A:undetectable | 4mm9A-3ec2A:16.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ed4 | ARYLSULFATASE (Escherichiacoli) |
PF00884(Sulfatase) | 5 | VAL A 192ALA A 246GLY A 272PHE A 270SER A 243 | None | 1.27A | 4mm9A-3ed4A:undetectable | 4mm9A-3ed4A:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fys | PROTEIN DEGV (Bacillussubtilis) |
PF02645(DegV) | 5 | ASP A 218VAL A 254TYR A 251SER A 222GLY A 224 | None | 1.28A | 4mm9A-3fysA:undetectable | 4mm9A-3fysA:21.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3glq | ADENOSYLHOMOCYSTEINASE (Burkholderiapseudomallei) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | ASP A 346TYR A 117GLY A 343GLY A 389ASP A 142 | NoneNoneNAD A 601 (-3.4A)NoneNone | 1.17A | 4mm9A-3glqA:undetectable | 4mm9A-3glqA:22.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h5l | PUTATIVEBRANCHED-CHAIN AMINOACID ABC TRANSPORTER (Ruegeriapomeroyi) |
PF13458(Peripla_BP_6) | 5 | ASP A 358VAL A 365ALA A 347GLY A 135ASP A 367 | None | 1.27A | 4mm9A-3h5lA:undetectable | 4mm9A-3h5lA:23.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hc1 | UNCHARACTERIZED HDODDOMAIN PROTEIN (Geobactersulfurreducens) |
PF08668(HDOD) | 5 | ASP A 152ALA A 129GLY A 246SER A 122GLY A 124 | FE A 306 ( 2.5A)NoneNoneNoneNone | 1.06A | 4mm9A-3hc1A:undetectable | 4mm9A-3hc1A:22.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hf9 | PROTEASOME (ALPHASUBUNIT) PRCA (Mycobacteriumtuberculosis) |
no annotation | 5 | TYR A 103VAL A 60ALA A 125GLY A 78ASP A 58 | None | 1.15A | 4mm9A-3hf9A:undetectable | 4mm9A-3hf9A:19.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hgq | HDA1 COMPLEX SUBUNIT3 (Saccharomycescerevisiae) |
PF11496(HDA2-3) | 5 | ASP A 245VAL A 266TYR A 262GLY A 81SER A 243 | None | 1.27A | 4mm9A-3hgqA:undetectable | 4mm9A-3hgqA:21.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hmj | FATTY ACID SYNTHASESUBUNIT ALPHA (Saccharomycescerevisiae) |
PF00109(ketoacyl-synt)PF01648(ACPS)PF02801(Ketoacyl-synt_C) | 5 | VAL A1864ALA A1862GLY A1770GLY A1824ASP A1866 | None | 1.24A | 4mm9A-3hmjA:undetectable | 4mm9A-3hmjA:13.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ive | NUCLEOTIDASE (Escherichiacoli) |
PF00149(Metallophos)PF02872(5_nucleotid_C) | 5 | ALA A 352TYR A 498GLY A 512SER A 347GLY A 349 | None | 1.30A | 4mm9A-3iveA:undetectable | 4mm9A-3iveA:23.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3khy | PROPIONATE KINASE (Francisellatularensis) |
PF00871(Acetate_kinase) | 5 | VAL A 210ALA A 209GLY A 175PHE A 145SER A 206 | None | 1.21A | 4mm9A-3khyA:undetectable | 4mm9A-3khyA:21.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lmk | METABOTROPICGLUTAMATE RECEPTOR 5 (Homo sapiens) |
PF01094(ANF_receptor) | 5 | ASP A 178ALA A 196GLY A 224SER A 176ASP A 233 | None | 1.24A | 4mm9A-3lmkA:undetectable | 4mm9A-3lmkA:20.21 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3mpn | TRANSPORTER (Aquifexaeolicus) |
PF00209(SNF) | 7 | VAL A 104ALA A 105TYR A 107TYR A 108PHE A 259SER A 355ASP A 404 | NoneNoneNoneLEU A 601 (-4.5A)LEU A 601 (-3.6A) NA A 751 ( 2.3A)None | 0.50A | 4mm9A-3mpnA:59.6 | 4mm9A-3mpnA:97.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pqs | TRANSFERRIN-BINDINGPROTEIN (Actinobacilluspleuropneumoniae) |
PF01298(TbpB_B_D)PF17483(TbpB_C)PF17484(TbpB_A) | 5 | VAL A 436ALA A 454GLY A 521GLY A 493ASP A 428 | NoneNoneNoneGOL A 529 (-3.4A)None | 1.22A | 4mm9A-3pqsA:undetectable | 4mm9A-3pqsA:20.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pqu | TRANSFERRIN BINDINGPROTEIN B (Actinobacillussuis) |
PF01298(TbpB_B_D)PF17483(TbpB_C)PF17484(TbpB_A) | 5 | VAL A 485ALA A 503GLY A 570GLY A 542ASP A 477 | None | 1.29A | 4mm9A-3pquA:undetectable | 4mm9A-3pquA:21.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sfz | APOPTOTIC PEPTIDASEACTIVATING FACTOR 1 (Mus musculus) |
PF00400(WD40)PF00931(NB-ARC)PF12894(ANAPC4_WD40) | 5 | ASP A 903VAL A 864ALA A 858SER A 901GLY A 887 | None | 1.13A | 4mm9A-3sfzA:undetectable | 4mm9A-3sfzA:18.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uj2 | ENOLASE 1 (Anaerostipescaccae) |
PF00113(Enolase_C)PF03952(Enolase_N) | 5 | ASP A 104VAL A 113ALA A 112GLY A 101SER A 106 | None | 1.23A | 4mm9A-3uj2A:undetectable | 4mm9A-3uj2A:22.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3usz | EXO-1,3/1,4-BETA-GLUCANASE (Pseudoalteromonassp. BB1) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C) | 5 | VAL A 164ALA A 163GLY A 237GLY A 218ASP A 180 | None | 1.08A | 4mm9A-3uszA:undetectable | 4mm9A-3uszA:20.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vu2 | 1,4-ALPHA-GLUCAN-BRANCHING ENZYME,CHLOROPLASTIC/AMYLOPLASTIC (Oryza sativa) |
PF00128(Alpha-amylase)PF02806(Alpha-amylase_C)PF02922(CBM_48) | 5 | VAL A 635ALA A 636TYR A 690GLY A 648SER A 639 | None | 1.21A | 4mm9A-3vu2A:undetectable | 4mm9A-3vu2A:22.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w3e | COTYLEDONEOUSYIELDIN-LIKE PROTEIN (Vignaunguiculata) |
PF00182(Glyco_hydro_19) | 5 | ASP A 213TYR A 221TYR A 81GLY A 71GLY A 79 | None | 1.26A | 4mm9A-3w3eA:undetectable | 4mm9A-3w3eA:17.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wec | CYTOCHROME P450 (Rhodococcuserythropolis) |
PF00067(p450) | 5 | ASP A 67ALA A 323GLY A 90GLY A 304ASP A 75 | NoneNoneNoneAUI A 502 (-3.5A)None | 1.08A | 4mm9A-3wecA:undetectable | 4mm9A-3wecA:23.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zlb | PHOSPHOGLYCERATEKINASE (Streptococcuspneumoniae) |
PF00162(PGK) | 5 | VAL A 290ALA A 289TYR A 233GLY A 300GLY A 287 | NoneNoneNoneNone MG A1400 ( 4.3A) | 1.19A | 4mm9A-3zlbA:undetectable | 4mm9A-3zlbA:24.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zuk | ENDOPEPTIDASE,PEPTIDASE FAMILY M13 (Mycobacteriumtuberculosis) |
PF01431(Peptidase_M13)PF05649(Peptidase_M13_N) | 5 | VAL A 596ALA A 482TYR A 484GLY A 567GLY A 486 | None | 1.26A | 4mm9A-3zukA:undetectable | 4mm9A-3zukA:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cot | EXTRACELLULARENDO-ALPHA-(1->5)-L-ARABINANASE 2 (Bacillussubtilis) |
PF04616(Glyco_hydro_43)PF16369(GH43_C) | 5 | ASP A 109VAL A 130ALA A 131TYR A 115TYR A 113 | None | 1.28A | 4mm9A-4cotA:undetectable | 4mm9A-4cotA:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cu8 | GLYCOSIDE HYDROLASE2 (Streptococcuspneumoniae) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N)PF16355(DUF4982) | 5 | VAL A 950ALA A 951TYR A 890TYR A 888GLY A 920 | NoneNoneEDO A2026 ( 4.1A)NoneNone | 1.05A | 4mm9A-4cu8A:undetectable | 4mm9A-4cu8A:21.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dkn | AMPHIOXUS GREENFLUORESCENT PROTEIN,GFPA1 (Branchiostomafloridae) |
PF01353(GFP) | 5 | ASP A 153ALA A 85TYR A 84TYR A 175SER A 173 | None | 1.29A | 4mm9A-4dknA:undetectable | 4mm9A-4dknA:18.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ezb | UNCHARACTERIZEDCONSERVED PROTEIN (Sinorhizobiummeliloti) |
PF03807(F420_oxidored)PF09130(DUF1932) | 5 | ASP A 96ALA A 13GLY A 74SER A 70GLY A 8 | None | 1.17A | 4mm9A-4ezbA:undetectable | 4mm9A-4ezbA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fwm | PROPIONATE KINASE (Salmonellaenterica) |
PF00871(Acetate_kinase) | 5 | VAL A 213ALA A 212GLY A 176PHE A 146SER A 209 | None | 1.28A | 4mm9A-4fwmA:undetectable | 4mm9A-4fwmA:24.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iig | BETA-GLUCOSIDASE 1 (Aspergillusaculeatus) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C)PF14310(Fn3-like) | 5 | VAL A 112GLY A 169SER A 162GLY A 160ASP A 117 | None | 1.18A | 4mm9A-4iigA:undetectable | 4mm9A-4iigA:20.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kpu | ELECTRON TRANSFERFLAVOPROTEIN ALPHASUBUNITELECTRON TRANSFERFLAVOPROTEINALPHA/BETA-SUBUNIT (Acidaminococcusfermentans) |
PF00766(ETF_alpha)PF01012(ETF) | 5 | ASP A 130ALA B 120TYR B 37GLY A 151GLY B 123 | NoneFAD B 301 (-3.3A)FAD A 401 (-4.1A)NoneFAD B 301 (-3.3A) | 1.20A | 4mm9A-4kpuA:undetectable | 4mm9A-4kpuA:20.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n5i | ESTERASE/LIPASE (Lactobacillusrhamnosus) |
PF07859(Abhydrolase_3) | 5 | VAL X 99ALA X 98SER X 94GLY X 96ASP X 71 | None | 1.27A | 4mm9A-4n5iX:undetectable | 4mm9A-4n5iX:22.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ohn | ABC TRANSPORTERSUBSTRATE-BINDINGPROTEIN (Streptococcuspneumoniae) |
PF00497(SBP_bac_3) | 5 | ALA A 62TYR A 61GLY A 44SER A 47GLY A 53 | None | 1.06A | 4mm9A-4ohnA:undetectable | 4mm9A-4ohnA:19.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p6v | NA(+)-TRANSLOCATINGNADH-QUINONEREDUCTASE SUBUNIT B (Vibrio cholerae) |
PF03116(NQR2_RnfD_RnfE) | 5 | ASP B 346VAL B 64ALA B 63GLY B 339PHE B 338 | NoneNoneNoneFMN B 600 ( 3.7A)FMN B 600 (-4.7A) | 1.18A | 4mm9A-4p6vB:undetectable | 4mm9A-4p6vB:25.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pag | PERIPLASMIC BINDINGPROTEIN (Sulfurospirillumdeleyianum) |
PF01497(Peripla_BP_2) | 5 | ASP A 286ALA A 192TYR A 191GLY A 229GLY A 194 | None | 1.12A | 4mm9A-4pagA:undetectable | 4mm9A-4pagA:21.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qav | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 2 (Neisseriameningitidis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | VAL A 351ALA A 350TYR A 352GLY A 236GLY A 346 | None | 1.25A | 4mm9A-4qavA:undetectable | 4mm9A-4qavA:23.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4s28 | PHOSPHOMETHYLPYRIMIDINE SYNTHASE,CHLOROPLASTIC (Arabidopsisthaliana) |
PF01964(ThiC_Rad_SAM) | 5 | ALA A 361TYR A 362GLY A 406GLY A 324ASP A 366 | None | 1.22A | 4mm9A-4s28A:undetectable | 4mm9A-4s28A:21.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uoo | LIPOTEICHOIC ACIDSYNTHASE (Listeriamonocytogenes) |
PF00884(Sulfatase) | 5 | TYR A 380VAL A 351ALA A 350GLY A 354SER A 401 | None | 1.28A | 4mm9A-4uooA:undetectable | 4mm9A-4uooA:20.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w5j | ADENYLATE KINASE (Streptococcuspneumoniae) |
PF00406(ADK) | 5 | ASP A 33GLY A 14SER A 30GLY A 86ASP A 159 | NoneAP5 A 302 (-3.5A)AP5 A 302 ( 4.9A)AP5 A 302 (-4.3A)None | 1.13A | 4mm9A-4w5jA:undetectable | 4mm9A-4w5jA:19.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x28 | ACYL-COADEHYDROGENASE (Mycobacteriumtuberculosis) |
no annotation | 5 | VAL D 289ALA D 286GLY D 222SER D 228ASP D 292 | None | 0.97A | 4mm9A-4x28D:undetectable | 4mm9A-4x28D:22.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xn3 | TAIL SPIKE PROTEIN (Salmonellavirus HK620) |
no annotation | 5 | ASP A 561VAL A 615ALA A 614GLY A 556PHE A 584 | None | 1.05A | 4mm9A-4xn3A:undetectable | 4mm9A-4xn3A:21.56 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4xnu | INTEGRAL MEMBRANEPROTEIN-DOPAMINETRANSPORTER (Drosophilamelanogaster) |
PF00209(SNF) | 5 | ASP A 46GLY A 322PHE A 325SER A 421GLY A 424 | 41U A 605 ( 3.3A)41U A 605 ( 4.1A)41U A 605 ( 4.7A) NA A 602 ( 2.4A)None | 0.92A | 4mm9A-4xnuA:41.6 | 4mm9A-4xnuA:30.62 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4xnu | INTEGRAL MEMBRANEPROTEIN-DOPAMINETRANSPORTER (Drosophilamelanogaster) |
PF00209(SNF) | 6 | ASP A 46TYR A 124GLY A 322PHE A 325SER A 421GLY A 425 | 41U A 605 ( 3.3A)41U A 605 ( 3.8A)41U A 605 ( 4.1A)41U A 605 ( 4.7A) NA A 602 ( 2.4A)41U A 605 ( 3.7A) | 0.72A | 4mm9A-4xnuA:41.6 | 4mm9A-4xnuA:30.62 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4xnu | INTEGRAL MEMBRANEPROTEIN-DOPAMINETRANSPORTER (Drosophilamelanogaster) |
PF00209(SNF) | 7 | ASP A 46VAL A 120TYR A 123TYR A 124GLY A 322SER A 421GLY A 425 | 41U A 605 ( 3.3A)41U A 605 (-4.2A)None41U A 605 ( 3.8A)41U A 605 ( 4.1A) NA A 602 ( 2.4A)41U A 605 ( 3.7A) | 0.50A | 4mm9A-4xnuA:41.6 | 4mm9A-4xnuA:30.62 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4xnu | INTEGRAL MEMBRANEPROTEIN-DOPAMINETRANSPORTER (Drosophilamelanogaster) |
PF00209(SNF) | 7 | ASP A 46VAL A 120TYR A 123TYR A 124SER A 421GLY A 425ASP A 475 | 41U A 605 ( 3.3A)41U A 605 (-4.2A)None41U A 605 ( 3.8A) NA A 602 ( 2.4A)41U A 605 ( 3.7A)None | 0.69A | 4mm9A-4xnuA:41.6 | 4mm9A-4xnuA:30.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yv2 | SPERMIDINE SYNTHASE,PUTATIVE (Trypanosomacruzi) |
PF01564(Spermine_synth)PF17284(Spermine_synt_N) | 5 | ASP A 168TYR A 73GLY A 99GLY A 78ASP A 69 | S4M A 301 (-3.1A)S4M A 301 (-4.4A)NoneNoneNone | 1.30A | 4mm9A-4yv2A:undetectable | 4mm9A-4yv2A:21.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b3h | PROTEIN SCARECROW (Arabidopsisthaliana) |
PF03514(GRAS) | 5 | VAL A 517ALA A 648GLY A 599PHE A 600GLY A 602 | None | 1.24A | 4mm9A-5b3hA:undetectable | 4mm9A-5b3hA:22.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eo6 | COPROPORPHYRINOGENOXIDASE (Acinetobacterbaumannii) |
PF01218(Coprogen_oxidas) | 5 | TYR A 252GLY A 137PHE A 195GLY A 192ASP A 257 | NoneNoneNoneNoneACT A 400 ( 4.2A) | 1.24A | 4mm9A-5eo6A:undetectable | 4mm9A-5eo6A:22.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5epg | ALDEHYDE OXIDASE (Homo sapiens) |
PF00111(Fer2)PF00941(FAD_binding_5)PF01315(Ald_Xan_dh_C)PF01799(Fer2_2)PF02738(Ald_Xan_dh_C2)PF03450(CO_deh_flav_C) | 5 | ASP A1093VAL A1163TYR A1161SER A1265GLY A1192 | None | 1.00A | 4mm9A-5epgA:undetectable | 4mm9A-5epgA:17.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fjj | BETA-GLUCOSIDASE (Aspergillusoryzae) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C)PF14310(Fn3-like) | 5 | VAL A 113GLY A 170SER A 163GLY A 161ASP A 118 | None | 1.20A | 4mm9A-5fjjA:undetectable | 4mm9A-5fjjA:22.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fse | UREASE SUBUNIT ALPHA (Sporosarcinapasteurii) |
PF00449(Urease_alpha)PF01979(Amidohydro_1) | 5 | VAL C 424ALA C 421GLY C 195GLY C 419ASP C 434 | None | 1.05A | 4mm9A-5fseC:undetectable | 4mm9A-5fseC:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g3z | ADENYLATE KINSE (syntheticconstruct) |
PF00406(ADK)PF05191(ADK_lid) | 5 | ASP A 33GLY A 14SER A 30GLY A 85ASP A 163 | NoneAP5 A1217 (-3.6A)AP5 A1217 ( 4.8A)AP5 A1217 (-4.3A)None | 1.17A | 4mm9A-5g3zA:undetectable | 4mm9A-5g3zA:16.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gwn | PROTEIN RCC2 (Homo sapiens) |
PF00415(RCC1) | 5 | VAL A 478TYR A 464GLY A 110PHE A 109GLY A 465 | None | 1.30A | 4mm9A-5gwnA:undetectable | 4mm9A-5gwnA:21.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hcc | COMPLEMENT C5 (Homo sapiens) |
PF00207(A2M)PF01759(NTR)PF01821(ANATO)PF07677(A2M_recep)PF07678(A2M_comp) | 5 | VAL A1423ALA A1422TYR A1496TYR A1498SER A1007 | None | 1.27A | 4mm9A-5hccA:undetectable | 4mm9A-5hccA:19.18 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5i6z | SODIUM-DEPENDENTSEROTONINTRANSPORTER (Homo sapiens) |
PF00209(SNF) | 6 | TYR A 95ASP A 98ALA A 169GLY A 338SER A 438GLY A 442 | None | 1.44A | 4mm9A-5i6zA:43.5 | 4mm9A-5i6zA:32.24 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5i6z | SODIUM-DEPENDENTSEROTONINTRANSPORTER (Homo sapiens) |
PF00209(SNF) | 8 | TYR A 95ASP A 98ALA A 173TYR A 175TYR A 176GLY A 338SER A 438GLY A 442 | None | 0.68A | 4mm9A-5i6zA:43.5 | 4mm9A-5i6zA:32.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j5d | 4-HYDROXY-TETRAHYDRODIPICOLINATESYNTHASE (Mycobacteriumtuberculosis) |
PF00701(DHDPS) | 5 | TYR A 191ASP A 144GLY A 180GLY A 169ASP A 156 | NoneNoneNoneNone NA A 402 (-3.3A) | 1.29A | 4mm9A-5j5dA:undetectable | 4mm9A-5j5dA:21.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jmv | PROBABLEBIFUNCTIONAL TRNATHREONYLCARBAMOYLADENOSINE BIOSYNTHESISPROTEIN (Methanocaldococcusjannaschii) |
PF00814(Peptidase_M22) | 5 | TYR A 221ALA A 227TYR A 190TYR A 226SER A 222 | None | 1.24A | 4mm9A-5jmvA:undetectable | 4mm9A-5jmvA:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m2n | ELONGATOR COMPLEXPROTEIN 2 (Saccharomycescerevisiae) |
PF00400(WD40) | 5 | ASP A 777VAL A 51GLY A 35SER A 779GLY A 383 | None | 1.27A | 4mm9A-5m2nA:undetectable | 4mm9A-5m2nA:20.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nnb | ISATIN HYDROLASE A (Labrenziaaggregata) |
no annotation | 5 | VAL A 251ALA A 236GLY A 71SER A 247ASP A 20 | None | 1.28A | 4mm9A-5nnbA:undetectable | 4mm9A-5nnbA:10.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ot1 | PULLULANASE TYPE II,GH13 FAMILY (Thermococcuskodakarensis) |
no annotation | 5 | TYR A 564VAL A 754ALA A 726SER A 721GLY A 703 | None | 1.26A | 4mm9A-5ot1A:undetectable | 4mm9A-5ot1A:10.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uj6 | GLYCOSYL HYDROLASESFAMILY 2, SUGARBINDING DOMAINPROTEIN (Bacteroidesuniformis) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N)PF11721(Malectin)PF16355(DUF4982) | 5 | ASP A 154ALA A 161GLY A 171SER A 113GLY A 128 | None | 1.19A | 4mm9A-5uj6A:undetectable | 4mm9A-5uj6A:19.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5usd | PEPTIDASE S66 (Bacillusanthracis) |
PF02016(Peptidase_S66) | 5 | ALA A 293TYR A 188PHE A 226SER A 296GLY A 263 | None | 1.21A | 4mm9A-5usdA:undetectable | 4mm9A-5usdA:20.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5va4 | TRIM5/CYCLOPHILIN AV4 FUSION PROTEIN (Aotustrivirgatus;Thermusthermophilus) |
no annotation | 5 | ASP A 216VAL A 135ALA A 136TYR A 139PHE A 130 | None | 1.29A | 4mm9A-5va4A:undetectable | 4mm9A-5va4A:12.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wan | PYRIMIDINEMONOOXYGENASE RUTA (Escherichiacoli) |
PF00296(Bac_luciferase) | 5 | VAL A 319ALA A 320PHE A 242SER A 238GLY A 327 | None | 1.04A | 4mm9A-5wanA:undetectable | 4mm9A-5wanA:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xnw | ADENYLATE CYCLASEEXOY (Pseudomonasaeruginosa) |
no annotation | 5 | VAL A 197ALA A 196GLY A 93PHE A 176ASP A 102 | None | 1.30A | 4mm9A-5xnwA:undetectable | 4mm9A-5xnwA:9.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xru | ADENYLATE KINASE (Nototheniacoriiceps) |
no annotation | 5 | ASP A 41GLY A 22SER A 38GLY A 94ASP A 141 | NoneAP5 A 201 (-3.5A)AP5 A 201 ( 4.8A)AP5 A 201 (-4.4A)None | 1.10A | 4mm9A-5xruA:undetectable | 4mm9A-5xruA:11.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f39 | COMPLEMENT C1RSUBCOMPONENT (Homo sapiens) |
no annotation | 5 | ASP A 226TYR A 197GLY A 252PHE A 223SER A 278 | CA A 303 (-3.2A)NoneNoneNone CA A 303 ( 3.8A) | 1.14A | 4mm9A-6f39A:undetectable | 4mm9A-6f39A:8.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fyd | PUTATIVEFAD-DEPENDENTOXYGENASE ENCM (Streptomycesmaritimus) |
no annotation | 5 | VAL A 85GLY A 39SER A 79GLY A 77ASP A 87 | NoneNoneFAD A 600 (-4.3A)FAD A 600 (-3.5A)None | 1.27A | 4mm9A-6fydA:undetectable | 4mm9A-6fydA:9.55 |