SIMILAR PATTERNS OF AMINO ACIDS FOR 4MM9_A_FVXA603_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbi AK.1 SERINE PROTEASE

(Bacillus sp.
Ak1)
PF00082
(Peptidase_S8)
5 ASP A  48
VAL A 211
ALA A 220
TYR A 219
GLY A  92
CA  A 701 (-2.2A)
None
None
None
None
1.09A 4mm9A-1dbiA:
0.0
4mm9A-1dbiA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ded CYCLODEXTRIN
GLUCANOTRANSFERASE


(Bacillus sp.
1011)
PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C)
5 ASP A 319
GLY A 505
SER A 279
GLY A 277
ASP A 577
None
1.29A 4mm9A-1dedA:
0.0
4mm9A-1dedA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dxj CLASS II CHITINASE

(Canavalia
ensiformis)
PF00182
(Glyco_hydro_19)
5 ASP A 213
TYR A 221
TYR A  81
GLY A  71
GLY A  79
None
1.27A 4mm9A-1dxjA:
undetectable
4mm9A-1dxjA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezw COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE


(Methanopyrus
kandleri)
PF00296
(Bac_luciferase)
5 ASP A 225
VAL A 195
ALA A 177
GLY A 318
PHE A 203
None
1.22A 4mm9A-1ezwA:
undetectable
4mm9A-1ezwA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fi8 ECOTIN
NATURAL KILLER CELL
PROTEASE 1


(Escherichia
coli;
Rattus
norvegicus)
PF00089
(Trypsin)
PF03974
(Ecotin)
5 ASP C  84
VAL A 138
GLY A 142
SER A 195
GLY A 197
None
1.14A 4mm9A-1fi8C:
undetectable
4mm9A-1fi8C:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g33 PARVALBUMIN ALPHA

(Rattus
norvegicus)
PF13499
(EF-hand_7)
5 ASP A  42
VAL A 106
ALA A 107
PHE A 102
SER A  39
None
1.29A 4mm9A-1g33A:
undetectable
4mm9A-1g33A:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gtm GLUTAMATE
DEHYDROGENASE


(Pyrococcus
furiosus)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
5 ALA A 194
TYR A 196
GLY A 185
GLY A 346
ASP A 234
None
1.18A 4mm9A-1gtmA:
0.3
4mm9A-1gtmA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i36 CONSERVED
HYPOTHETICAL PROTEIN
MTH1747


(Methanothermobacter
thermautotrophicus)
PF03807
(F420_oxidored)
PF09130
(DUF1932)
5 ASP A  86
VAL A  11
ALA A  12
SER A  62
GLY A   7
None
NAP  A1350 (-3.8A)
None
None
NAP  A1350 (-3.4A)
1.11A 4mm9A-1i36A:
0.5
4mm9A-1i36A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lq2 BETA-D-GLUCAN
GLUCOHYDROLASE
ISOENZYME EXO1


(Hordeum vulgare)
PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
5 VAL A 150
ALA A 149
GLY A 229
GLY A 210
ASP A 166
None
1.15A 4mm9A-1lq2A:
0.0
4mm9A-1lq2A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1j FIBRINOGEN ALPHA
SUBUNIT
FIBRINOGEN BETA
CHAIN


(Gallus gallus)
PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha)
5 TYR B 421
GLY B 263
SER B 450
GLY B 423
ASP A 154
None
1.29A 4mm9A-1m1jB:
undetectable
4mm9A-1m1jB:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhk PROTEIN
(RIBONUCLEASE HI)


(Saccharomyces
cerevisiae)
PF01693
(Cauli_VI)
5 VAL A  11
ALA A  10
TYR A  20
TYR A   9
GLY A  35
None
0.92A 4mm9A-1qhkA:
undetectable
4mm9A-1qhkA:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tuh HYPOTHETICAL PROTEIN
EGC068


(uncultured
bacterium)
PF12680
(SnoaL_2)
5 TYR A  32
VAL A 131
GLY A 103
GLY A  31
ASP A 133
None
1.13A 4mm9A-1tuhA:
undetectable
4mm9A-1tuhA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1udx THE GTP-BINDING
PROTEIN OBG


(Thermus
thermophilus)
PF01018
(GTP1_OBG)
PF01926
(MMR_HSR1)
PF09269
(DUF1967)
5 VAL A  20
ALA A  19
GLY A  32
PHE A  22
GLY A  73
None
1.08A 4mm9A-1udxA:
undetectable
4mm9A-1udxA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT


(Thermotoga
maritima)
PF01039
(Carboxyl_trans)
5 VAL A 174
ALA A 173
TYR A 175
GLY A 196
GLY A 132
None
None
None
BCT  A 517 (-3.7A)
None
1.20A 4mm9A-1vrgA:
0.0
4mm9A-1vrgA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w0m TRIOSEPHOSPHATE
ISOMERASE


(Thermoproteus
tenax)
PF00121
(TIM)
PF05690
(ThiG)
5 VAL A  89
ALA A  61
TYR A  60
GLY A 114
GLY A  86
None
1.15A 4mm9A-1w0mA:
undetectable
4mm9A-1w0mA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8o BACTERIAL SIALIDASE

(Micromonospora
viridifaciens)
PF00754
(F5_F8_type_C)
PF10633
(NPCBM_assoc)
PF13088
(BNR_2)
5 TYR A 296
ASP A 291
ALA A 250
SER A 295
ASP A 242
None
GOL  A1652 (-4.9A)
None
None
None
1.28A 4mm9A-1w8oA:
undetectable
4mm9A-1w8oA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wqa PHOSPHO-SUGAR MUTASE

(Pyrococcus
horikoshii)
PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III)
5 VAL A  72
GLY A  27
SER A  67
GLY A  69
ASP A  74
VAL  A  72 ( 0.6A)
GLY  A  27 ( 0.0A)
SER  A  67 ( 0.0A)
GLY  A  69 ( 0.0A)
ASP  A  74 ( 0.6A)
1.04A 4mm9A-1wqaA:
undetectable
4mm9A-1wqaA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT


(Thermotoga
maritima)
PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
5 ALA A 617
TYR A 614
GLY A 246
PHE A 247
GLY A 624
None
1.30A 4mm9A-1xjeA:
undetectable
4mm9A-1xjeA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkq SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5D234)


(Caenorhabditis
elegans)
PF13561
(adh_short_C2)
5 ASP A 170
VAL A 257
ALA A 258
GLY A 152
SER A 147
None
1.30A 4mm9A-1xkqA:
undetectable
4mm9A-1xkqA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xny PROPIONYL-COA
CARBOXYLASE COMPLEX
B SUBUNIT


(Streptomyces
coelicolor)
PF01039
(Carboxyl_trans)
5 VAL A 185
ALA A 184
TYR A 186
GLY A 207
GLY A 143
None
None
None
None
1VU  A5601 (-3.4A)
1.15A 4mm9A-1xnyA:
undetectable
4mm9A-1xnyA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zak ADENYLATE KINASE

(Zea mays)
PF00406
(ADK)
5 ASP A  38
GLY A  19
SER A  35
GLY A  91
ASP A 160
None
AP5  A 223 (-3.6A)
None
AP5  A 223 (-4.9A)
None
1.10A 4mm9A-1zakA:
undetectable
4mm9A-1zakA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9v GMP SYNTHASE

(Thermoplasma
acidophilum)
PF00117
(GATase)
5 ASP A   8
VAL A  65
TYR A  68
SER A  49
GLY A  82
None
1.16A 4mm9A-2a9vA:
undetectable
4mm9A-2a9vA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cdp BETA-AGARASE 1

(Saccharophagus
degradans)
PF03422
(CBM_6)
5 TYR A  63
VAL A 108
PHE A  76
SER A  62
GLY A 105
None
CL  A1144 ( 4.2A)
None
None
EDO  A1141 (-4.0A)
1.13A 4mm9A-2cdpA:
undetectable
4mm9A-2cdpA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfm THERMOSTABLE DNA
LIGASE


(Pyrococcus
furiosus)
PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C)
5 ALA A 151
TYR A   3
TYR A 153
GLY A 160
GLY A  91
None
1.29A 4mm9A-2cfmA:
undetectable
4mm9A-2cfmA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cy8 D-PHENYLGLYCINE
AMINOTRANSFERASE


(Pseudomonas
stutzeri)
PF00202
(Aminotran_3)
5 ASP A 201
ALA A 231
GLY A 138
SER A 200
GLY A 235
None
1.29A 4mm9A-2cy8A:
undetectable
4mm9A-2cy8A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9y ACETYL-COA
CARBOXYLASE,
CARBOXYLTRANSFERASE
ALPHA CHAIN
ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
BETA


(Escherichia
coli)
PF01039
(Carboxyl_trans)
PF03255
(ACCA)
5 ALA A 180
TYR A 140
GLY B 204
PHE B 227
SER B 209
None
1.23A 4mm9A-2f9yA:
undetectable
4mm9A-2f9yA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6l UDP-GLUCURONOSYLTRAN
SFERASE 2B7


(Homo sapiens)
PF00201
(UDPGT)
5 ASP A 435
VAL A 413
ALA A 412
SER A 437
GLY A 410
None
1.27A 4mm9A-2o6lA:
undetectable
4mm9A-2o6lA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE


(Methanocaldococcus
jannaschii)
PF00814
(Peptidase_M22)
PF01163
(RIO1)
5 TYR A 221
ALA A 227
TYR A 190
TYR A 226
SER A 222
None
1.27A 4mm9A-2vwbA:
undetectable
4mm9A-2vwbA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zez S-LAYER ASSOCIATED
MULTIDOMAIN
ENDOGLUCANASE


(Caldanaerobius
polysaccharolyticus)
PF02018
(CBM_4_9)
5 ALA A  46
PHE A 134
SER A 130
GLY A  42
ASP A  77
None
1.25A 4mm9A-2zezA:
undetectable
4mm9A-2zezA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bf0 PROTEASE 4

(Escherichia
coli)
PF01343
(Peptidase_S49)
5 TYR A 485
VAL A 492
ALA A 493
GLY A 433
PHE A 488
None
1.18A 4mm9A-3bf0A:
undetectable
4mm9A-3bf0A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctd PUTATIVE ATPASE, AAA
FAMILY


(Prochlorococcus
marinus)
PF12002
(MgsA_C)
PF16193
(AAA_assoc_2)
5 VAL A 318
ALA A 340
TYR A 343
GLY A 308
SER A 347
None
1.28A 4mm9A-3ctdA:
undetectable
4mm9A-3ctdA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dnf 4-HYDROXY-3-METHYLBU
T-2-ENYL DIPHOSPHATE
REDUCTASE


(Aquifex
aeolicus)
PF02401
(LYTB)
5 VAL A  20
ALA A  19
GLY A  11
PHE A  12
GLY A  15
None
None
None
None
F3S  A2302 (-3.4A)
1.20A 4mm9A-3dnfA:
undetectable
4mm9A-3dnfA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ec2 DNA REPLICATION
PROTEIN DNAC


(Aquifex
aeolicus)
PF01695
(IstB_IS21)
5 ASP A 198
TYR A 212
GLY A 151
SER A 201
GLY A 204
None
1.25A 4mm9A-3ec2A:
undetectable
4mm9A-3ec2A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ed4 ARYLSULFATASE

(Escherichia
coli)
PF00884
(Sulfatase)
5 VAL A 192
ALA A 246
GLY A 272
PHE A 270
SER A 243
None
1.27A 4mm9A-3ed4A:
undetectable
4mm9A-3ed4A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fys PROTEIN DEGV

(Bacillus
subtilis)
PF02645
(DegV)
5 ASP A 218
VAL A 254
TYR A 251
SER A 222
GLY A 224
None
1.28A 4mm9A-3fysA:
undetectable
4mm9A-3fysA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3glq ADENOSYLHOMOCYSTEINA
SE


(Burkholderia
pseudomallei)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 ASP A 346
TYR A 117
GLY A 343
GLY A 389
ASP A 142
None
None
NAD  A 601 (-3.4A)
None
None
1.17A 4mm9A-3glqA:
undetectable
4mm9A-3glqA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5l PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER


(Ruegeria
pomeroyi)
PF13458
(Peripla_BP_6)
5 ASP A 358
VAL A 365
ALA A 347
GLY A 135
ASP A 367
None
1.27A 4mm9A-3h5lA:
undetectable
4mm9A-3h5lA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN


(Geobacter
sulfurreducens)
PF08668
(HDOD)
5 ASP A 152
ALA A 129
GLY A 246
SER A 122
GLY A 124
FE  A 306 ( 2.5A)
None
None
None
None
1.06A 4mm9A-3hc1A:
undetectable
4mm9A-3hc1A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hf9 PROTEASOME (ALPHA
SUBUNIT) PRCA


(Mycobacterium
tuberculosis)
no annotation 5 TYR A 103
VAL A  60
ALA A 125
GLY A  78
ASP A  58
None
1.15A 4mm9A-3hf9A:
undetectable
4mm9A-3hf9A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hgq HDA1 COMPLEX SUBUNIT
3


(Saccharomyces
cerevisiae)
PF11496
(HDA2-3)
5 ASP A 245
VAL A 266
TYR A 262
GLY A  81
SER A 243
None
1.27A 4mm9A-3hgqA:
undetectable
4mm9A-3hgqA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA


(Saccharomyces
cerevisiae)
PF00109
(ketoacyl-synt)
PF01648
(ACPS)
PF02801
(Ketoacyl-synt_C)
5 VAL A1864
ALA A1862
GLY A1770
GLY A1824
ASP A1866
None
1.24A 4mm9A-3hmjA:
undetectable
4mm9A-3hmjA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ive NUCLEOTIDASE

(Escherichia
coli)
PF00149
(Metallophos)
PF02872
(5_nucleotid_C)
5 ALA A 352
TYR A 498
GLY A 512
SER A 347
GLY A 349
None
1.30A 4mm9A-3iveA:
undetectable
4mm9A-3iveA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khy PROPIONATE KINASE

(Francisella
tularensis)
PF00871
(Acetate_kinase)
5 VAL A 210
ALA A 209
GLY A 175
PHE A 145
SER A 206
None
1.21A 4mm9A-3khyA:
undetectable
4mm9A-3khyA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmk METABOTROPIC
GLUTAMATE RECEPTOR 5


(Homo sapiens)
PF01094
(ANF_receptor)
5 ASP A 178
ALA A 196
GLY A 224
SER A 176
ASP A 233
None
1.24A 4mm9A-3lmkA:
undetectable
4mm9A-3lmkA:
20.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mpn TRANSPORTER

(Aquifex
aeolicus)
PF00209
(SNF)
7 VAL A 104
ALA A 105
TYR A 107
TYR A 108
PHE A 259
SER A 355
ASP A 404
None
None
None
LEU  A 601 (-4.5A)
LEU  A 601 (-3.6A)
NA  A 751 ( 2.3A)
None
0.50A 4mm9A-3mpnA:
59.6
4mm9A-3mpnA:
97.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqs TRANSFERRIN-BINDING
PROTEIN


(Actinobacillus
pleuropneumoniae)
PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A)
5 VAL A 436
ALA A 454
GLY A 521
GLY A 493
ASP A 428
None
None
None
GOL  A 529 (-3.4A)
None
1.22A 4mm9A-3pqsA:
undetectable
4mm9A-3pqsA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqu TRANSFERRIN BINDING
PROTEIN B


(Actinobacillus
suis)
PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A)
5 VAL A 485
ALA A 503
GLY A 570
GLY A 542
ASP A 477
None
1.29A 4mm9A-3pquA:
undetectable
4mm9A-3pquA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1


(Mus musculus)
PF00400
(WD40)
PF00931
(NB-ARC)
PF12894
(ANAPC4_WD40)
5 ASP A 903
VAL A 864
ALA A 858
SER A 901
GLY A 887
None
1.13A 4mm9A-3sfzA:
undetectable
4mm9A-3sfzA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uj2 ENOLASE 1

(Anaerostipes
caccae)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
5 ASP A 104
VAL A 113
ALA A 112
GLY A 101
SER A 106
None
1.23A 4mm9A-3uj2A:
undetectable
4mm9A-3uj2A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3usz EXO-1,3/1,4-BETA-GLU
CANASE


(Pseudoalteromonas
sp. BB1)
PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
5 VAL A 164
ALA A 163
GLY A 237
GLY A 218
ASP A 180
None
1.08A 4mm9A-3uszA:
undetectable
4mm9A-3uszA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vu2 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME,
CHLOROPLASTIC/AMYLOP
LASTIC


(Oryza sativa)
PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48)
5 VAL A 635
ALA A 636
TYR A 690
GLY A 648
SER A 639
None
1.21A 4mm9A-3vu2A:
undetectable
4mm9A-3vu2A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w3e COTYLEDONEOUS
YIELDIN-LIKE PROTEIN


(Vigna
unguiculata)
PF00182
(Glyco_hydro_19)
5 ASP A 213
TYR A 221
TYR A  81
GLY A  71
GLY A  79
None
1.26A 4mm9A-3w3eA:
undetectable
4mm9A-3w3eA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wec CYTOCHROME P450

(Rhodococcus
erythropolis)
PF00067
(p450)
5 ASP A  67
ALA A 323
GLY A  90
GLY A 304
ASP A  75
None
None
None
AUI  A 502 (-3.5A)
None
1.08A 4mm9A-3wecA:
undetectable
4mm9A-3wecA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zlb PHOSPHOGLYCERATE
KINASE


(Streptococcus
pneumoniae)
PF00162
(PGK)
5 VAL A 290
ALA A 289
TYR A 233
GLY A 300
GLY A 287
None
None
None
None
MG  A1400 ( 4.3A)
1.19A 4mm9A-3zlbA:
undetectable
4mm9A-3zlbA:
24.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13


(Mycobacterium
tuberculosis)
PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N)
5 VAL A 596
ALA A 482
TYR A 484
GLY A 567
GLY A 486
None
1.26A 4mm9A-3zukA:
undetectable
4mm9A-3zukA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cot EXTRACELLULAR
ENDO-ALPHA-(1->5)-L-
ARABINANASE 2


(Bacillus
subtilis)
PF04616
(Glyco_hydro_43)
PF16369
(GH43_C)
5 ASP A 109
VAL A 130
ALA A 131
TYR A 115
TYR A 113
None
1.28A 4mm9A-4cotA:
undetectable
4mm9A-4cotA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cu8 GLYCOSIDE HYDROLASE
2


(Streptococcus
pneumoniae)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982)
5 VAL A 950
ALA A 951
TYR A 890
TYR A 888
GLY A 920
None
None
EDO  A2026 ( 4.1A)
None
None
1.05A 4mm9A-4cu8A:
undetectable
4mm9A-4cu8A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dkn AMPHIOXUS GREEN
FLUORESCENT PROTEIN,
GFPA1


(Branchiostoma
floridae)
PF01353
(GFP)
5 ASP A 153
ALA A  85
TYR A  84
TYR A 175
SER A 173
None
1.29A 4mm9A-4dknA:
undetectable
4mm9A-4dknA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ezb UNCHARACTERIZED
CONSERVED PROTEIN


(Sinorhizobium
meliloti)
PF03807
(F420_oxidored)
PF09130
(DUF1932)
5 ASP A  96
ALA A  13
GLY A  74
SER A  70
GLY A   8
None
1.17A 4mm9A-4ezbA:
undetectable
4mm9A-4ezbA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwm PROPIONATE KINASE

(Salmonella
enterica)
PF00871
(Acetate_kinase)
5 VAL A 213
ALA A 212
GLY A 176
PHE A 146
SER A 209
None
1.28A 4mm9A-4fwmA:
undetectable
4mm9A-4fwmA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iig BETA-GLUCOSIDASE 1

(Aspergillus
aculeatus)
PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like)
5 VAL A 112
GLY A 169
SER A 162
GLY A 160
ASP A 117
None
1.18A 4mm9A-4iigA:
undetectable
4mm9A-4iigA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpu ELECTRON TRANSFER
FLAVOPROTEIN ALPHA
SUBUNIT
ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA/BETA-SUBUNIT


(Acidaminococcus
fermentans)
PF00766
(ETF_alpha)
PF01012
(ETF)
5 ASP A 130
ALA B 120
TYR B  37
GLY A 151
GLY B 123
None
FAD  B 301 (-3.3A)
FAD  A 401 (-4.1A)
None
FAD  B 301 (-3.3A)
1.20A 4mm9A-4kpuA:
undetectable
4mm9A-4kpuA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n5i ESTERASE/LIPASE

(Lactobacillus
rhamnosus)
PF07859
(Abhydrolase_3)
5 VAL X  99
ALA X  98
SER X  94
GLY X  96
ASP X  71
None
1.27A 4mm9A-4n5iX:
undetectable
4mm9A-4n5iX:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ohn ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN


(Streptococcus
pneumoniae)
PF00497
(SBP_bac_3)
5 ALA A  62
TYR A  61
GLY A  44
SER A  47
GLY A  53
None
1.06A 4mm9A-4ohnA:
undetectable
4mm9A-4ohnA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B


(Vibrio cholerae)
PF03116
(NQR2_RnfD_RnfE)
5 ASP B 346
VAL B  64
ALA B  63
GLY B 339
PHE B 338
None
None
None
FMN  B 600 ( 3.7A)
FMN  B 600 (-4.7A)
1.18A 4mm9A-4p6vB:
undetectable
4mm9A-4p6vB:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pag PERIPLASMIC BINDING
PROTEIN


(Sulfurospirillum
deleyianum)
PF01497
(Peripla_BP_2)
5 ASP A 286
ALA A 192
TYR A 191
GLY A 229
GLY A 194
None
1.12A 4mm9A-4pagA:
undetectable
4mm9A-4pagA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qav 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2


(Neisseria
meningitidis)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
5 VAL A 351
ALA A 350
TYR A 352
GLY A 236
GLY A 346
None
1.25A 4mm9A-4qavA:
undetectable
4mm9A-4qavA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s28 PHOSPHOMETHYLPYRIMID
INE SYNTHASE,
CHLOROPLASTIC


(Arabidopsis
thaliana)
PF01964
(ThiC_Rad_SAM)
5 ALA A 361
TYR A 362
GLY A 406
GLY A 324
ASP A 366
None
1.22A 4mm9A-4s28A:
undetectable
4mm9A-4s28A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uoo LIPOTEICHOIC ACID
SYNTHASE


(Listeria
monocytogenes)
PF00884
(Sulfatase)
5 TYR A 380
VAL A 351
ALA A 350
GLY A 354
SER A 401
None
1.28A 4mm9A-4uooA:
undetectable
4mm9A-4uooA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w5j ADENYLATE KINASE

(Streptococcus
pneumoniae)
PF00406
(ADK)
5 ASP A  33
GLY A  14
SER A  30
GLY A  86
ASP A 159
None
AP5  A 302 (-3.5A)
AP5  A 302 ( 4.9A)
AP5  A 302 (-4.3A)
None
1.13A 4mm9A-4w5jA:
undetectable
4mm9A-4w5jA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x28 ACYL-COA
DEHYDROGENASE


(Mycobacterium
tuberculosis)
no annotation 5 VAL D 289
ALA D 286
GLY D 222
SER D 228
ASP D 292
None
0.97A 4mm9A-4x28D:
undetectable
4mm9A-4x28D:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xn3 TAIL SPIKE PROTEIN

(Salmonella
virus HK620)
no annotation 5 ASP A 561
VAL A 615
ALA A 614
GLY A 556
PHE A 584
None
1.05A 4mm9A-4xn3A:
undetectable
4mm9A-4xn3A:
21.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER


(Drosophila
melanogaster)
PF00209
(SNF)
5 ASP A  46
GLY A 322
PHE A 325
SER A 421
GLY A 424
41U  A 605 ( 3.3A)
41U  A 605 ( 4.1A)
41U  A 605 ( 4.7A)
NA  A 602 ( 2.4A)
None
0.92A 4mm9A-4xnuA:
41.6
4mm9A-4xnuA:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER


(Drosophila
melanogaster)
PF00209
(SNF)
6 ASP A  46
TYR A 124
GLY A 322
PHE A 325
SER A 421
GLY A 425
41U  A 605 ( 3.3A)
41U  A 605 ( 3.8A)
41U  A 605 ( 4.1A)
41U  A 605 ( 4.7A)
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
0.72A 4mm9A-4xnuA:
41.6
4mm9A-4xnuA:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER


(Drosophila
melanogaster)
PF00209
(SNF)
7 ASP A  46
VAL A 120
TYR A 123
TYR A 124
GLY A 322
SER A 421
GLY A 425
41U  A 605 ( 3.3A)
41U  A 605 (-4.2A)
None
41U  A 605 ( 3.8A)
41U  A 605 ( 4.1A)
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
0.50A 4mm9A-4xnuA:
41.6
4mm9A-4xnuA:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER


(Drosophila
melanogaster)
PF00209
(SNF)
7 ASP A  46
VAL A 120
TYR A 123
TYR A 124
SER A 421
GLY A 425
ASP A 475
41U  A 605 ( 3.3A)
41U  A 605 (-4.2A)
None
41U  A 605 ( 3.8A)
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
None
0.69A 4mm9A-4xnuA:
41.6
4mm9A-4xnuA:
30.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yv2 SPERMIDINE SYNTHASE,
PUTATIVE


(Trypanosoma
cruzi)
PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N)
5 ASP A 168
TYR A  73
GLY A  99
GLY A  78
ASP A  69
S4M  A 301 (-3.1A)
S4M  A 301 (-4.4A)
None
None
None
1.30A 4mm9A-4yv2A:
undetectable
4mm9A-4yv2A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3h PROTEIN SCARECROW

(Arabidopsis
thaliana)
PF03514
(GRAS)
5 VAL A 517
ALA A 648
GLY A 599
PHE A 600
GLY A 602
None
1.24A 4mm9A-5b3hA:
undetectable
4mm9A-5b3hA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eo6 COPROPORPHYRINOGEN
OXIDASE


(Acinetobacter
baumannii)
PF01218
(Coprogen_oxidas)
5 TYR A 252
GLY A 137
PHE A 195
GLY A 192
ASP A 257
None
None
None
None
ACT  A 400 ( 4.2A)
1.24A 4mm9A-5eo6A:
undetectable
4mm9A-5eo6A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epg ALDEHYDE OXIDASE

(Homo sapiens)
PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C)
5 ASP A1093
VAL A1163
TYR A1161
SER A1265
GLY A1192
None
1.00A 4mm9A-5epgA:
undetectable
4mm9A-5epgA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fjj BETA-GLUCOSIDASE

(Aspergillus
oryzae)
PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like)
5 VAL A 113
GLY A 170
SER A 163
GLY A 161
ASP A 118
None
1.20A 4mm9A-5fjjA:
undetectable
4mm9A-5fjjA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fse UREASE SUBUNIT ALPHA

(Sporosarcina
pasteurii)
PF00449
(Urease_alpha)
PF01979
(Amidohydro_1)
5 VAL C 424
ALA C 421
GLY C 195
GLY C 419
ASP C 434
None
1.05A 4mm9A-5fseC:
undetectable
4mm9A-5fseC:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g3z ADENYLATE KINSE

(synthetic
construct)
PF00406
(ADK)
PF05191
(ADK_lid)
5 ASP A  33
GLY A  14
SER A  30
GLY A  85
ASP A 163
None
AP5  A1217 (-3.6A)
AP5  A1217 ( 4.8A)
AP5  A1217 (-4.3A)
None
1.17A 4mm9A-5g3zA:
undetectable
4mm9A-5g3zA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gwn PROTEIN RCC2

(Homo sapiens)
PF00415
(RCC1)
5 VAL A 478
TYR A 464
GLY A 110
PHE A 109
GLY A 465
None
1.30A 4mm9A-5gwnA:
undetectable
4mm9A-5gwnA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hcc COMPLEMENT C5

(Homo sapiens)
PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
5 VAL A1423
ALA A1422
TYR A1496
TYR A1498
SER A1007
None
1.27A 4mm9A-5hccA:
undetectable
4mm9A-5hccA:
19.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i6z SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER


(Homo sapiens)
PF00209
(SNF)
6 TYR A  95
ASP A  98
ALA A 169
GLY A 338
SER A 438
GLY A 442
None
1.44A 4mm9A-5i6zA:
43.5
4mm9A-5i6zA:
32.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i6z SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER


(Homo sapiens)
PF00209
(SNF)
8 TYR A  95
ASP A  98
ALA A 173
TYR A 175
TYR A 176
GLY A 338
SER A 438
GLY A 442
None
0.68A 4mm9A-5i6zA:
43.5
4mm9A-5i6zA:
32.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5d 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE


(Mycobacterium
tuberculosis)
PF00701
(DHDPS)
5 TYR A 191
ASP A 144
GLY A 180
GLY A 169
ASP A 156
None
None
None
None
NA  A 402 (-3.3A)
1.29A 4mm9A-5j5dA:
undetectable
4mm9A-5j5dA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jmv PROBABLE
BIFUNCTIONAL TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN


(Methanocaldococcus
jannaschii)
PF00814
(Peptidase_M22)
5 TYR A 221
ALA A 227
TYR A 190
TYR A 226
SER A 222
None
1.24A 4mm9A-5jmvA:
undetectable
4mm9A-5jmvA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m2n ELONGATOR COMPLEX
PROTEIN 2


(Saccharomyces
cerevisiae)
PF00400
(WD40)
5 ASP A 777
VAL A  51
GLY A  35
SER A 779
GLY A 383
None
1.27A 4mm9A-5m2nA:
undetectable
4mm9A-5m2nA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nnb ISATIN HYDROLASE A

(Labrenzia
aggregata)
no annotation 5 VAL A 251
ALA A 236
GLY A  71
SER A 247
ASP A  20
None
1.28A 4mm9A-5nnbA:
undetectable
4mm9A-5nnbA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ot1 PULLULANASE TYPE II,
GH13 FAMILY


(Thermococcus
kodakarensis)
no annotation 5 TYR A 564
VAL A 754
ALA A 726
SER A 721
GLY A 703
None
1.26A 4mm9A-5ot1A:
undetectable
4mm9A-5ot1A:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj6 GLYCOSYL HYDROLASES
FAMILY 2, SUGAR
BINDING DOMAIN
PROTEIN


(Bacteroides
uniformis)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF11721
(Malectin)
PF16355
(DUF4982)
5 ASP A 154
ALA A 161
GLY A 171
SER A 113
GLY A 128
None
1.19A 4mm9A-5uj6A:
undetectable
4mm9A-5uj6A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5usd PEPTIDASE S66

(Bacillus
anthracis)
PF02016
(Peptidase_S66)
5 ALA A 293
TYR A 188
PHE A 226
SER A 296
GLY A 263
None
1.21A 4mm9A-5usdA:
undetectable
4mm9A-5usdA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5va4 TRIM5/CYCLOPHILIN A
V4 FUSION PROTEIN


(Aotus
trivirgatus;
Thermus
thermophilus)
no annotation 5 ASP A 216
VAL A 135
ALA A 136
TYR A 139
PHE A 130
None
1.29A 4mm9A-5va4A:
undetectable
4mm9A-5va4A:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wan PYRIMIDINE
MONOOXYGENASE RUTA


(Escherichia
coli)
PF00296
(Bac_luciferase)
5 VAL A 319
ALA A 320
PHE A 242
SER A 238
GLY A 327
None
1.04A 4mm9A-5wanA:
undetectable
4mm9A-5wanA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnw ADENYLATE CYCLASE
EXOY


(Pseudomonas
aeruginosa)
no annotation 5 VAL A 197
ALA A 196
GLY A  93
PHE A 176
ASP A 102
None
1.30A 4mm9A-5xnwA:
undetectable
4mm9A-5xnwA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xru ADENYLATE KINASE

(Notothenia
coriiceps)
no annotation 5 ASP A  41
GLY A  22
SER A  38
GLY A  94
ASP A 141
None
AP5  A 201 (-3.5A)
AP5  A 201 ( 4.8A)
AP5  A 201 (-4.4A)
None
1.10A 4mm9A-5xruA:
undetectable
4mm9A-5xruA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f39 COMPLEMENT C1R
SUBCOMPONENT


(Homo sapiens)
no annotation 5 ASP A 226
TYR A 197
GLY A 252
PHE A 223
SER A 278
CA  A 303 (-3.2A)
None
None
None
CA  A 303 ( 3.8A)
1.14A 4mm9A-6f39A:
undetectable
4mm9A-6f39A:
8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyd PUTATIVE
FAD-DEPENDENT
OXYGENASE ENCM


(Streptomyces
maritimus)
no annotation 5 VAL A  85
GLY A  39
SER A  79
GLY A  77
ASP A  87
None
None
FAD  A 600 (-4.3A)
FAD  A 600 (-3.5A)
None
1.27A 4mm9A-6fydA:
undetectable
4mm9A-6fydA:
9.55