SIMILAR PATTERNS OF AMINO ACIDS FOR 4MM8_A_RFXA603_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a5l | UREASE (ALPHASUBUNIT) (Klebsiellaaerogenes) |
PF00449(Urease_alpha)PF01979(Amidohydro_1) | 5 | VAL C 421ALA C 418GLY C 192GLY C 416ASP C 431 | None | 1.09A | 4mm8A-1a5lC:undetectable | 4mm8A-1a5lC:21.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1by1 | PROTEIN (PIX) (Homo sapiens) |
PF00621(RhoGEF) | 5 | ALA A 133GLY A 144SER A 135GLY A 137THR A 34 | None | 1.19A | 4mm8A-1by1A:undetectable | 4mm8A-1by1A:16.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cjl | PROCATHEPSIN L (Homo sapiens) |
PF00112(Peptidase_C1)PF08246(Inhibitor_I29) | 5 | ALA A 73TYR A 72GLY A 86PHE A 112ASP A 79 | None | 1.15A | 4mm8A-1cjlA:0.0 | 4mm8A-1cjlA:19.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dbi | AK.1 SERINE PROTEASE (Bacillus sp.Ak1) |
PF00082(Peptidase_S8) | 5 | ASP A 48VAL A 211ALA A 220TYR A 219GLY A 92 | CA A 701 (-2.2A)NoneNoneNoneNone | 1.04A | 4mm8A-1dbiA:0.1 | 4mm8A-1dbiA:20.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e08 | [FE]-HYDROGENASE(LARGE SUBUNIT) (Desulfovibriodesulfuricans) |
PF02906(Fe_hyd_lg_C)PF13187(Fer4_9) | 5 | VAL A 110ALA A 109GLY A 70GLY A 381THR A 260 | PDT A 4 (-4.3A)PDT A 4 ( 3.1A)SF4 A 2 (-3.8A)SF4 A 3 ( 3.9A)None | 1.17A | 4mm8A-1e08A:0.0 | 4mm8A-1e08A:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lkd | BIPHENYL-2,3-DIOL1,2-DIOXYGENASE (Paraburkholderiaxenovorans) |
PF00903(Glyoxalase) | 5 | ASP A 39VAL A 13ALA A 12GLY A 10ASP A 15 | None | 1.09A | 4mm8A-1lkdA:undetectable | 4mm8A-1lkdA:22.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lq2 | BETA-D-GLUCANGLUCOHYDROLASEISOENZYME EXO1 (Hordeum vulgare) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C) | 5 | VAL A 150ALA A 149GLY A 229GLY A 210ASP A 166 | None | 1.19A | 4mm8A-1lq2A:0.0 | 4mm8A-1lq2A:19.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m1c | MAJOR COAT PROTEIN (Saccharomycescerevisiaevirus L-A) |
PF09220(LA-virus_coat) | 5 | VAL A 32TYR A 47PHE A 474SER A 50THR A 591 | None | 1.07A | 4mm8A-1m1cA:0.0 | 4mm8A-1m1cA:21.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ovm | INDOLE-3-PYRUVATEDECARBOXYLASE (Enterobactercloacae) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | ALA A 541GLY A 384PHE A 388ASP A 289THR A 290 | NoneTPP A 600 (-3.5A)NoneNoneNone | 1.14A | 4mm8A-1ovmA:0.0 | 4mm8A-1ovmA:22.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ovm | INDOLE-3-PYRUVATEDECARBOXYLASE (Enterobactercloacae) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | GLY A 384PHE A 388GLY A 540ASP A 289THR A 290 | TPP A 600 (-3.5A)NoneNoneNoneNone | 1.12A | 4mm8A-1ovmA:0.0 | 4mm8A-1ovmA:22.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qhk | PROTEIN(RIBONUCLEASE HI) (Saccharomycescerevisiae) |
PF01693(Cauli_VI) | 5 | VAL A 11ALA A 10TYR A 20TYR A 9GLY A 35 | None | 0.90A | 4mm8A-1qhkA:undetectable | 4mm8A-1qhkA:6.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r9h | FK506 BINDINGPROTEIN FAMILY (Caenorhabditiselegans) |
PF00254(FKBP_C) | 5 | VAL A 16SER A 92GLY A 95ASP A 7THR A 9 | None | 1.21A | 4mm8A-1r9hA:undetectable | 4mm8A-1r9hA:14.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tuh | HYPOTHETICAL PROTEINEGC068 (unculturedbacterium) |
PF12680(SnoaL_2) | 5 | TYR A 32VAL A 131GLY A 103GLY A 31ASP A 133 | None | 1.18A | 4mm8A-1tuhA:undetectable | 4mm8A-1tuhA:14.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1udx | THE GTP-BINDINGPROTEIN OBG (Thermusthermophilus) |
PF01018(GTP1_OBG)PF01926(MMR_HSR1)PF09269(DUF1967) | 5 | VAL A 20ALA A 19GLY A 32PHE A 22GLY A 73 | None | 1.16A | 4mm8A-1udxA:0.0 | 4mm8A-1udxA:22.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vdk | FUMARATE HYDRATASECLASS II (Thermusthermophilus) |
PF00206(Lyase_1)PF10415(FumaraseC_C) | 5 | ASP A 142VAL A 246ALA A 247GLY A 137PHE A 242 | None | 1.20A | 4mm8A-1vdkA:undetectable | 4mm8A-1vdkA:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vr4 | HYPOTHETICAL PROTEINAPC22750 (Bacillus cereus) |
PF01906(YbjQ_1) | 5 | VAL A 94ALA A 95TYR A 84SER A 97GLY A 23 | None | 1.08A | 4mm8A-1vr4A:undetectable | 4mm8A-1vr4A:11.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vra | ARGININEBIOSYNTHESISBIFUNCTIONAL PROTEINARGJ (Bacillushalodurans) |
PF01960(ArgJ) | 5 | VAL A 18GLY A 41PHE A 154SER A 25GLY A 150 | NoneNoneNoneNoneEDO A 204 ( 3.8A) | 1.18A | 4mm8A-1vraA:undetectable | 4mm8A-1vraA:17.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xje | RIBONUCLEOTIDEREDUCTASE,B12-DEPENDENT (Thermotogamaritima) |
PF00317(Ribonuc_red_lgN)PF02867(Ribonuc_red_lgC) | 5 | ALA A 617TYR A 614GLY A 246PHE A 247GLY A 624 | None | 1.16A | 4mm8A-1xjeA:undetectable | 4mm8A-1xjeA:22.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xny | PROPIONYL-COACARBOXYLASE COMPLEXB SUBUNIT (Streptomycescoelicolor) |
PF01039(Carboxyl_trans) | 5 | VAL A 185ALA A 184TYR A 186GLY A 207GLY A 143 | NoneNoneNoneNone1VU A5601 (-3.4A) | 1.21A | 4mm8A-1xnyA:undetectable | 4mm8A-1xnyA:21.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z68 | FIBROBLASTACTIVATION PROTEIN,ALPHA SUBUNIT (Homo sapiens) |
PF00326(Peptidase_S9)PF00930(DPPIV_N) | 5 | VAL A 540TYR A 541GLY A 593SER A 624GLY A 627 | None | 1.13A | 4mm8A-1z68A:undetectable | 4mm8A-1z68A:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zxx | 6-PHOSPHOFRUCTOKINASE (Lactobacillusdelbrueckii) |
PF00365(PFK) | 5 | VAL A 20GLY A 124SER A 265GLY A 268THR A 8 | None | 1.21A | 4mm8A-1zxxA:undetectable | 4mm8A-1zxxA:22.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d5l | DIPEPTIDYLAMINOPEPTIDASE IV,PUTATIVE (Porphyromonasgingivalis) |
PF00326(Peptidase_S9)PF00930(DPPIV_N) | 5 | VAL A 517TYR A 518GLY A 572SER A 603GLY A 606 | None | 1.08A | 4mm8A-2d5lA:undetectable | 4mm8A-2d5lA:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h88 | SUCCINATEDEHYDROGENASEFLAVOPROTEIN SUBUNIT (Gallus gallus) |
PF00890(FAD_binding_2)PF02910(Succ_DH_flav_C) | 5 | TYR A 220GLY A 369SER A 229GLY A 231THR A 535 | None K A 622 ( 4.7A)FAD A1001 ( 4.9A)NoneNone | 1.06A | 4mm8A-2h88A:undetectable | 4mm8A-2h88A:22.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iht | CARBOXYETHYLARGININESYNTHASE (Streptomycesclavuligerus) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 6 | ASP A 409VAL A 62ALA A 63PHE A 58ASP A 98THR A 94 | None | 1.21A | 4mm8A-2ihtA:undetectable | 4mm8A-2ihtA:22.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iq1 | PROTEIN PHOSPHATASE2C KAPPA, PPM1K (Homo sapiens) |
PF00481(PP2C) | 5 | VAL A 125ALA A 124GLY A 207ASP A 109THR A 297 | NoneNoneNone MG A 1 ( 4.9A)None | 1.17A | 4mm8A-2iq1A:undetectable | 4mm8A-2iq1A:18.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wk2 | CHITINASE A (Serratiamarcescens) |
PF00704(Glyco_hydro_18)PF08329(ChitinaseA_N) | 5 | ALA A 442GLY A 525SER A 538GLY A 440ASP A 517 | None | 1.00A | 4mm8A-2wk2A:undetectable | 4mm8A-2wk2A:23.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x05 | EXO-BETA-D-GLUCOSAMINIDASE (Amycolatopsisorientalis) |
PF00703(Glyco_hydro_2)PF02837(Glyco_hydro_2_N) | 5 | ASP A 256VAL A 261ALA A 260GLY A 225THR A 263 | None | 1.21A | 4mm8A-2x05A:undetectable | 4mm8A-2x05A:18.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z8z | LIPASE (Pseudomonas sp.MIS38) |
PF00353(HemolysinCabind) | 5 | TYR A 40GLY A 321SER A 346ASP A 33THR A 316 | None | 1.21A | 4mm8A-2z8zA:undetectable | 4mm8A-2z8zA:22.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zzg | ALANYL-TRNASYNTHETASE (Pyrococcushorikoshii) |
PF01411(tRNA-synt_2c)PF07973(tRNA_SAD) | 5 | VAL A 167ALA A 170PHE A 202ASP A 164THR A 7 | None | 1.23A | 4mm8A-2zzgA:undetectable | 4mm8A-2zzgA:21.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aje | PUTATIVEUNCHARACTERIZEDPROTEIN ST1526 (Sulfurisphaeratokodaii) |
PF01300(Sua5_yciO_yrdC)PF03481(SUA5) | 5 | VAL A 294ALA A 295GLY A 317PHE A 318GLY A 324 | None | 1.01A | 4mm8A-3ajeA:undetectable | 4mm8A-3ajeA:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b9e | CHITINASE A (Vibrio harveyi) |
PF00704(Glyco_hydro_18)PF08329(ChitinaseA_N) | 5 | ALA A 459GLY A 556SER A 569GLY A 457ASP A 548 | None | 1.04A | 4mm8A-3b9eA:undetectable | 4mm8A-3b9eA:24.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bjr | PUTATIVECARBOXYLESTERASE (Lactobacillusplantarum) |
PF07859(Abhydrolase_3) | 5 | TYR A 18VAL A 47ALA A 48GLY A 17SER A 52 | NoneGOL A 265 (-3.9A)GOL A 265 (-3.3A)NoneNone | 1.12A | 4mm8A-3bjrA:undetectable | 4mm8A-3bjrA:18.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ce6 | ADENOSYLHOMOCYSTEINASE (Mycobacteriumtuberculosis) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | ASP A 365TYR A 133GLY A 362GLY A 411ASP A 159 | NoneNoneNAD A 550 (-3.5A)NoneNone | 1.19A | 4mm8A-3ce6A:undetectable | 4mm8A-3ce6A:22.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e6c | CYCLICNUCLEOTIDE-BINDINGPROTEIN (Desulfitobacteriumhafniense) |
PF00027(cNMP_binding)PF13545(HTH_Crp_2) | 5 | VAL C 43ALA C 42GLY C 59GLY C 40THR C 104 | None | 1.13A | 4mm8A-3e6cC:undetectable | 4mm8A-3e6cC:19.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3glq | ADENOSYLHOMOCYSTEINASE (Burkholderiapseudomallei) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | ASP A 346TYR A 117GLY A 343GLY A 389ASP A 142 | NoneNoneNAD A 601 (-3.4A)NoneNone | 1.13A | 4mm8A-3glqA:undetectable | 4mm8A-3glqA:22.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hf9 | PROTEASOME (ALPHASUBUNIT) PRCA (Mycobacteriumtuberculosis) |
no annotation | 5 | TYR A 103VAL A 60ALA A 125GLY A 78ASP A 58 | None | 1.21A | 4mm8A-3hf9A:undetectable | 4mm8A-3hf9A:19.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mc1 | PREDICTEDPHOSPHATASE, HADFAMILY (Clostridiumacetobutylicum) |
PF13419(HAD_2) | 5 | ASP A 10VAL A 105ALA A 106SER A 108GLY A 132 | GOL A 303 ( 3.8A)NoneNoneNoneNone | 1.07A | 4mm8A-3mc1A:undetectable | 4mm8A-3mc1A:17.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mkh | NITROALKANE OXIDASE (Podosporaanserina) |
PF00441(Acyl-CoA_dh_1)PF02771(Acyl-CoA_dh_N) | 5 | TYR A 51GLY A 62SER A 56GLY A 124THR A 99 | None | 1.12A | 4mm8A-3mkhA:undetectable | 4mm8A-3mkhA:22.84 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3mpn | TRANSPORTER (Aquifexaeolicus) |
PF00209(SNF) | 7 | VAL A 104ALA A 105TYR A 107TYR A 108PHE A 259SER A 356ASP A 404 | NoneNoneNoneLEU A 601 (-4.5A)LEU A 601 (-3.6A)NoneNone | 0.42A | 4mm8A-3mpnA:60.4 | 4mm8A-3mpnA:97.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n2t | PUTATIVEOXIDOREDUCTASE (Gluconobacteroxydans) |
PF00248(Aldo_ket_red) | 5 | VAL A 68ALA A 71GLY A 27GLY A 38THR A 55 | None | 1.06A | 4mm8A-3n2tA:undetectable | 4mm8A-3n2tA:22.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o8l | 6-PHOSPHOFRUCTOKINASE, MUSCLE TYPE (Oryctolaguscuniculus) |
PF00365(PFK) | 5 | VAL A 34GLY A 163SER A 314GLY A 317THR A 22 | None | 1.09A | 4mm8A-3o8lA:undetectable | 4mm8A-3o8lA:21.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3one | ADENOSYLHOMOCYSTEINASE (Lupinus luteus) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | ASP A 352TYR A 117GLY A 349GLY A 399ASP A 142 | NoneNoneNAD A 501 (-3.5A)NoneNone | 1.17A | 4mm8A-3oneA:undetectable | 4mm8A-3oneA:22.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3puk | SYNTAXIN-BINDINGPROTEIN 3 (Mus musculus) |
PF00995(Sec1) | 5 | TYR A 160GLY A 538SER A 443GLY A 446THR A 247 | None | 1.14A | 4mm8A-3pukA:undetectable | 4mm8A-3pukA:20.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pw3 | AMINOPEPTIDASE C (Parabacteroidesdistasonis) |
PF03051(Peptidase_C1_2) | 5 | VAL A 284ALA A 283GLY A 33PHE A 34GLY A 281 | EDO A 431 (-3.9A)NoneNoneEDO A 431 (-4.9A)None | 1.09A | 4mm8A-3pw3A:undetectable | 4mm8A-3pw3A:19.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q6d | PROLINE DIPEPTIDASE (Bacillusanthracis) |
PF00557(Peptidase_M24)PF01321(Creatinase_N) | 5 | ALA A 312GLY A 214GLY A 290ASP A 331THR A 344 | None | 1.04A | 4mm8A-3q6dA:undetectable | 4mm8A-3q6dA:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q9o | EXOTOXIN A (Vibrio cholerae) |
PF09009(Exotox-A_cataly)PF09101(Exotox-A_bind)PF09102(Exotox-A_target) | 5 | TYR A 365GLY A 374SER A 381GLY A 383THR A 370 | GOL A 801 (-4.1A)NoneGOL A 801 (-2.6A)NoneNone | 1.03A | 4mm8A-3q9oA:undetectable | 4mm8A-3q9oA:20.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qs2 | FIMBRILLIN MATBHOMOLOG (Escherichiacoli) |
PF16449(MatB) | 5 | VAL A 148ALA A 147GLY A 144ASP A 150THR A 153 | IOD A 205 ( 4.0A)NoneNoneNoneNone | 1.22A | 4mm8A-3qs2A:undetectable | 4mm8A-3qs2A:16.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rgw | MEMBRANE-BOUNDHYDROGENASE (NIFE)LARGE SUBUNIT HOXG (Cupriavidusnecator) |
PF00374(NiFeSe_Hases) | 5 | ALA L 568GLY L 8SER L 572GLY L 297ASP L 561 | None | 1.22A | 4mm8A-3rgwL:undetectable | 4mm8A-3rgwL:22.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sd7 | PUTATIVE PHOSPHATASE (Clostridioidesdifficile) |
PF13419(HAD_2) | 5 | ASP A 13VAL A 107ALA A 108SER A 110GLY A 134 | NoneNoneNoneNoneGOL A 221 (-4.2A) | 1.00A | 4mm8A-3sd7A:undetectable | 4mm8A-3sd7A:19.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3usz | EXO-1,3/1,4-BETA-GLUCANASE (Pseudoalteromonassp. BB1) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C) | 5 | VAL A 164ALA A 163GLY A 237GLY A 218ASP A 180 | None | 1.15A | 4mm8A-3uszA:undetectable | 4mm8A-3uszA:20.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uw2 | PHOSPHOGLUCOMUTASE/PHOSPHOMANNOMUTASEFAMILY PROTEIN (Burkholderiathailandensis) |
PF00408(PGM_PMM_IV)PF02878(PGM_PMM_I)PF02879(PGM_PMM_II)PF02880(PGM_PMM_III) | 6 | ASP A 63VAL A 72GLY A 29SER A 148GLY A 69ASP A 74 | EDO A 467 (-3.8A)NoneNoneNoneNoneNone | 1.26A | 4mm8A-3uw2A:undetectable | 4mm8A-3uw2A:22.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w40 | PHOSPHOSERINEPHOSPHATASE RSBX (Bacillussubtilis) |
PF07228(SpoIIE) | 5 | VAL A 42ALA A 41GLY A 108ASP A 27THR A 155 | NoneNoneNone MG A 201 ( 4.6A)None | 1.21A | 4mm8A-3w40A:undetectable | 4mm8A-3w40A:16.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wec | CYTOCHROME P450 (Rhodococcuserythropolis) |
PF00067(p450) | 5 | ASP A 67ALA A 323GLY A 90GLY A 304ASP A 75 | NoneNoneNoneAUI A 502 (-3.5A)None | 1.15A | 4mm8A-3wecA:undetectable | 4mm8A-3wecA:23.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zuk | ENDOPEPTIDASE,PEPTIDASE FAMILY M13 (Mycobacteriumtuberculosis) |
PF01431(Peptidase_M13)PF05649(Peptidase_M13_N) | 5 | VAL A 596ALA A 482TYR A 484GLY A 567GLY A 486 | None | 1.22A | 4mm8A-3zukA:undetectable | 4mm8A-3zukA:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a3s | 6-PHOSPHOFRUCTOKINASE (Bacillussubtilis) |
PF00365(PFK) | 5 | VAL A 20GLY A 124SER A 265GLY A 268THR A 8 | None | 1.17A | 4mm8A-4a3sA:undetectable | 4mm8A-4a3sA:20.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c51 | CATALASE-PEROXIDASE (Mycobacteriumtuberculosis) |
PF00141(peroxidase) | 5 | ASP A 735VAL A 545ALA A 476SER A 481ASP A 542 | None | 1.21A | 4mm8A-4c51A:undetectable | 4mm8A-4c51A:22.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cu8 | GLYCOSIDE HYDROLASE2 (Streptococcuspneumoniae) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N)PF16355(DUF4982) | 5 | VAL A 950ALA A 951TYR A 890TYR A 888GLY A 920 | NoneNoneEDO A2026 ( 4.1A)NoneNone | 1.11A | 4mm8A-4cu8A:undetectable | 4mm8A-4cu8A:21.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4da1 | PROTEIN PHOSPHATASE1K, MITOCHONDRIAL (Homo sapiens) |
PF00481(PP2C) | 5 | VAL A 125ALA A 124GLY A 207ASP A 109THR A 297 | NoneNoneNone MG A 504 ( 4.7A)None | 1.11A | 4mm8A-4da1A:undetectable | 4mm8A-4da1A:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gk9 | AGGLUTININ (BOA) (Burkholderiaoklahomensis) |
no annotation | 5 | VAL A 214ALA A 213TYR A 212GLY A 180SER A 206 | None | 1.22A | 4mm8A-4gk9A:undetectable | 4mm8A-4gk9A:18.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hvl | MEMBRANE-ANCHOREDMYCOSIN MYCP1 (Mycolicibacteriumthermoresistibile) |
PF00082(Peptidase_S8) | 5 | VAL A 90ALA A 89GLY A 133ASP A 92THR A 127 | None | 1.17A | 4mm8A-4hvlA:undetectable | 4mm8A-4hvlA:20.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k2h | INTRACELLULARPROTEASE/AMIDASE (Salmonellaenterica) |
PF01965(DJ-1_PfpI) | 5 | VAL A 122TYR A 136GLY A 154SER A 104ASP A 138 | None | 1.03A | 4mm8A-4k2hA:undetectable | 4mm8A-4k2hA:17.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kpg | MEMBRANE-ANCHOREDMYCOSIN MYCP1 (Mycolicibacteriumsmegmatis) |
PF00082(Peptidase_S8) | 5 | VAL A 90ALA A 89GLY A 133ASP A 92THR A 127 | None | 1.23A | 4mm8A-4kpgA:undetectable | 4mm8A-4kpgA:21.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nhd | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 3 PROTEIN 1 (Vibrio cholerae) |
PF08541(ACP_syn_III_C)PF08545(ACP_syn_III) | 5 | ASP A 182VAL A 214ALA A 215GLY A 186GLY A 304 | NoneNoneNoneNoneSCY A 112 ( 3.3A) | 1.08A | 4mm8A-4nhdA:undetectable | 4mm8A-4nhdA:21.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4psp | ALPHA-FUCOSIDASEGH29 (Fusariumgraminearum) |
PF01120(Alpha_L_fucos)PF16757(Fucosidase_C) | 5 | ASP A 303VAL A 167ALA A 120TYR A 32GLY A 30 | GOL A 622 (-2.6A)NoneNoneNoneNone | 1.16A | 4mm8A-4pspA:undetectable | 4mm8A-4pspA:22.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q1v | PUTATIVE DIPEPTIDYLAMINOPEPTIDASE IV (Bacteroidesovatus) |
PF00326(Peptidase_S9)PF00930(DPPIV_N) | 5 | VAL A 517TYR A 518GLY A 572SER A 603GLY A 606 | NonePEG A 801 ( 4.0A)NoneNoneNone | 1.06A | 4mm8A-4q1vA:undetectable | 4mm8A-4q1vA:21.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rt6 | HEME/HEMOPEXIN-BINDING PROTEIN (Haemophilusinfluenzae) |
PF05860(Haemagg_act) | 5 | ASP A 484GLY A 592PHE A 593ASP A 619THR A 622 | None | 1.11A | 4mm8A-4rt6A:undetectable | 4mm8A-4rt6A:19.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u1r | ATP-DEPENDENT6-PHOSPHOFRUCTOKINASE, PLATELET TYPE (Homo sapiens) |
PF00365(PFK) | 5 | VAL A 43GLY A 172SER A 323GLY A 326THR A 31 | None | 1.17A | 4mm8A-4u1rA:undetectable | 4mm8A-4u1rA:23.11 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4xnu | INTEGRAL MEMBRANEPROTEIN-DOPAMINETRANSPORTER (Drosophilamelanogaster) |
PF00209(SNF) | 5 | ASP A 46GLY A 322PHE A 325SER A 422GLY A 425 | 41U A 605 ( 3.3A)41U A 605 ( 4.1A)41U A 605 ( 4.7A)None41U A 605 ( 3.7A) | 0.99A | 4mm8A-4xnuA:42.2 | 4mm8A-4xnuA:30.62 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4xnu | INTEGRAL MEMBRANEPROTEIN-DOPAMINETRANSPORTER (Drosophilamelanogaster) |
PF00209(SNF) | 7 | ASP A 46VAL A 120TYR A 123TYR A 124GLY A 322SER A 422GLY A 425 | 41U A 605 ( 3.3A)41U A 605 (-4.2A)None41U A 605 ( 3.8A)41U A 605 ( 4.1A)None41U A 605 ( 3.7A) | 0.80A | 4mm8A-4xnuA:42.2 | 4mm8A-4xnuA:30.62 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4xnu | INTEGRAL MEMBRANEPROTEIN-DOPAMINETRANSPORTER (Drosophilamelanogaster) |
PF00209(SNF) | 7 | ASP A 46VAL A 120TYR A 123TYR A 124SER A 422GLY A 425ASP A 475 | 41U A 605 ( 3.3A)41U A 605 (-4.2A)None41U A 605 ( 3.8A)None41U A 605 ( 3.7A)None | 0.94A | 4mm8A-4xnuA:42.2 | 4mm8A-4xnuA:30.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yb9 | SOLUTE CARRIERFAMILY 2,FACILITATED GLUCOSETRANSPORTER MEMBER 5 (Bos taurus) |
PF00083(Sugar_tr) | 5 | VAL D 36ALA D 37TYR D 298TYR D 297GLY D 173 | None | 0.88A | 4mm8A-4yb9D:undetectable | 4mm8A-4yb9D:25.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yt9 | PEPTIDYLARGININEDEIMINASE (Porphyromonasgingivalis) |
PF04371(PAD_porph) | 5 | VAL A 93ALA A 94PHE A 118SER A 97THR A 91 | None | 1.19A | 4mm8A-4yt9A:undetectable | 4mm8A-4yt9A:20.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z5y | COENZYME PQQSYNTHESIS PROTEIN B (Pseudomonasputida) |
PF12706(Lactamase_B_2) | 5 | ASP A 92GLY A 13SER A 41GLY A 7THR A 222 | None | 1.09A | 4mm8A-4z5yA:undetectable | 4mm8A-4z5yA:20.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z5y | COENZYME PQQSYNTHESIS PROTEIN B (Pseudomonasputida) |
PF12706(Lactamase_B_2) | 5 | GLY A 12SER A 41GLY A 7ASP A 220THR A 222 | None | 1.12A | 4mm8A-4z5yA:undetectable | 4mm8A-4z5yA:20.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z7r | COENZYME PQQSYNTHESIS PROTEIN B (Methylobacteriumextorquens) |
PF12706(Lactamase_B_2) | 6 | ASP A 92GLY A 13SER A 41GLY A 7ASP A 216THR A 218 | ZN A 302 (-2.3A)NoneNoneNoneNoneNone | 1.38A | 4mm8A-4z7rA:undetectable | 4mm8A-4z7rA:22.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z7r | COENZYME PQQSYNTHESIS PROTEIN B (Methylobacteriumextorquens) |
PF12706(Lactamase_B_2) | 5 | GLY A 12SER A 41GLY A 7ASP A 216THR A 218 | None | 1.13A | 4mm8A-4z7rA:undetectable | 4mm8A-4z7rA:22.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zgv | FERREDOXIN RECEPTOR (Pectobacteriumatrosepticum) |
PF07715(Plug) | 5 | TYR A 409GLY A 333SER A 156GLY A 154ASP A 374 | None | 1.14A | 4mm8A-4zgvA:undetectable | 4mm8A-4zgvA:19.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ab4 | SCP2-THIOLASE LIKEPROTEIN (Trypanosomabrucei) |
no annotation | 5 | VAL A 216ALA A 215GLY A 10SER A 29THR A 366 | None | 1.22A | 4mm8A-5ab4A:undetectable | 4mm8A-5ab4A:23.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fml | PA SUBUNIT OFINFLUENZA BPOLYMERASEPB2 SUBUNIT OFINFLUENZA BPOLYMERASE (Influenza Bvirus) |
PF00603(Flu_PA)no annotation | 5 | TYR B 46ALA B 88GLY A 754GLY B 82THR A 761 | None | 0.94A | 4mm8A-5fmlB:undetectable | 4mm8A-5fmlB:17.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fse | UREASE SUBUNIT ALPHA (Sporosarcinapasteurii) |
PF00449(Urease_alpha)PF01979(Amidohydro_1) | 5 | VAL C 424ALA C 421GLY C 195GLY C 419ASP C 434 | None | 1.01A | 4mm8A-5fseC:undetectable | 4mm8A-5fseC:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ftz | CHITIN BINDINGPROTEIN (Streptomyceslividans) |
PF03067(LPMO_10) | 5 | VAL A 183ALA A 182GLY A 71ASP A 124THR A 185 | None | 1.18A | 4mm8A-5ftzA:undetectable | 4mm8A-5ftzA:15.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gl9 | BETA-LACTAMASE (Burkholderiathailandensis) |
PF13354(Beta-lactamase2) | 5 | ASP A 276ALA A 283GLY A 244SER A 281ASP A 233 | None | 1.15A | 4mm8A-5gl9A:undetectable | 4mm8A-5gl9A:18.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ha5 | BRUCELLA OVISOXIDOREDUCTASE (Brucella ovis) |
PF13561(adh_short_C2) | 5 | VAL A 151ALA A 152PHE A 214SER A 156GLY A 158 | None | 1.14A | 4mm8A-5ha5A:undetectable | 4mm8A-5ha5A:20.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ho9 | EXTRACELLULARARABINANASE (Geobacillusstearothermophilus) |
PF04616(Glyco_hydro_43)PF16369(GH43_C) | 5 | TYR A 149VAL A 180ALA A 160SER A 151GLY A 162 | None | 1.11A | 4mm8A-5ho9A:undetectable | 4mm8A-5ho9A:20.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5huo | NICOTINATE-NUCLEOTIDE DIPHOSPHORYLASE(CARBOXYLATING) (Streptococcuspyogenes) |
PF01729(QRPTase_C)PF02749(QRPTase_N) | 5 | ASP A 82ALA A 152TYR A 151ASP A 7THR A 58 | None | 1.18A | 4mm8A-5huoA:undetectable | 4mm8A-5huoA:19.92 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5i6z | SODIUM-DEPENDENTSEROTONINTRANSPORTER (Homo sapiens) |
PF00209(SNF) | 8 | TYR A 95ASP A 98ALA A 173TYR A 175TYR A 176GLY A 338GLY A 442THR A 497 | None | 0.91A | 4mm8A-5i6zA:43.8 | 4mm8A-5i6zA:32.24 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5i6z | SODIUM-DEPENDENTSEROTONINTRANSPORTER (Homo sapiens) |
PF00209(SNF) | 8 | TYR A 95ASP A 98TYR A 175TYR A 176GLY A 338SER A 439GLY A 442THR A 497 | None | 1.11A | 4mm8A-5i6zA:43.8 | 4mm8A-5i6zA:32.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jen | ANTI-SIGMA-V FACTORRSIVLYSOZYME C (Bacillussubtilis;Gallus gallus) |
PF00062(Lys)PF11738(DUF3298)PF13739(DUF4163) | 5 | ASP A 253VAL B 109ALA B 110GLY A 260THR A 164 | NA A 400 ( 3.9A)NoneNone NA A 401 ( 4.7A)None | 1.04A | 4mm8A-5jenA:undetectable | 4mm8A-5jenA:18.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l1b | GLUTAMATE RECEPTOR2,GLUTAMATE RECEPTOR2 (Rattusnorvegicus) |
PF00060(Lig_chan)PF01094(ANF_receptor)PF10613(Lig_chan-Glu_bd) | 5 | VAL A 396ALA A 472GLY A 239GLY A 470THR A 394 | None | 1.13A | 4mm8A-5l1bA:undetectable | 4mm8A-5l1bA:21.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mzo | UDP-GLUCOSE-GLYCOPROTEINGLUCOSYLTRANSFERASE-LIKE PROTEIN (Chaetomiumthermophilum) |
PF06427(UDP-g_GGTase) | 5 | VAL A1289TYR A1263GLY A1056GLY A1375THR A1072 | None | 1.19A | 4mm8A-5mzoA:undetectable | 4mm8A-5mzoA:17.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n40 | PUTATIVE INVASIN (Yersiniapseudotuberculosis) |
PF05689(DUF823)PF09134(Invasin_D3) | 5 | VAL A2528ALA A2492GLY A2444GLY A2532THR A2537 | None | 1.01A | 4mm8A-5n40A:undetectable | 4mm8A-5n40A:19.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nbs | BETA-GLUCOSIDASE (Neurosporacrassa) |
no annotation | 5 | ALA A 184GLY A 105PHE A 157GLY A 142THR A 171 | None | 1.21A | 4mm8A-5nbsA:undetectable | 4mm8A-5nbsA:10.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5olj | DIPEPTIDYL PEPTIDASEIV (Porphyromonasgingivalis) |
PF00326(Peptidase_S9)PF00930(DPPIV_N) | 5 | TYR A 511GLY A 562SER A 593GLY A 596ASP A 542 | GOL A 801 (-4.4A)NoneGOL A 801 (-2.5A)NoneNone | 1.16A | 4mm8A-5oljA:undetectable | 4mm8A-5oljA:21.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vbu | CYTOCHROME P45021-HYDROXYLASE (Homo sapiens) |
PF00067(p450) | 5 | VAL A 360ALA A 363GLY A 431GLY A 423THR A 296 | HEM A 501 ( 4.3A)HEM A 501 ( 3.7A)HEM A 501 (-3.6A)HEM A 501 ( 4.4A)HEM A 501 (-3.7A) | 1.21A | 4mm8A-5vbuA:undetectable | 4mm8A-5vbuA:22.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w0x | TIP41-LIKE PROTEIN (Mus musculus) |
no annotation | 5 | ASP A 115VAL A 248ALA A 247TYR A 214SER A 216 | None | 1.11A | 4mm8A-5w0xA:undetectable | 4mm8A-5w0xA:8.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xoe | ATP-DEPENDENT6-PHOSPHOFRUCTOKINASE (Staphylococcusaureus) |
no annotation | 5 | VAL A 20GLY A 126SER A 267GLY A 270THR A 8 | None | 1.16A | 4mm8A-5xoeA:undetectable | 4mm8A-5xoeA:10.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zl9 | CHITINASE AB (Serratiamarcescens) |
no annotation | 5 | ALA A 444GLY A 527SER A 540GLY A 442ASP A 519 | NoneNoneNoneNoneGOL A 701 (-4.3A) | 1.06A | 4mm8A-5zl9A:undetectable | 4mm8A-5zl9A:10.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fpe | TRNA N6-ADENOSINETHREONYLCARBAMOYLTRANSFERASE (Thermotogamaritima) |
no annotation | 5 | VAL B 239ALA B 238GLY B 178PHE B 164SER B 234 | NoneNonePEG B 402 (-3.4A)PEG B 402 ( 4.8A)None | 1.21A | 4mm8A-6fpeB:undetectable | 4mm8A-6fpeB:9.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6g3d | ARGININOSUCCINATELYASE (Chelativoranssp. BNC1) |
no annotation | 5 | VAL A 232ALA A 233TYR A 320SER A 321ASP A 114 | None | 1.13A | 4mm8A-6g3dA:undetectable | 4mm8A-6g3dA:10.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gh2 | LAMINARIBIOSEPHOSPHORYLASE (Paenibacillussp. YM1) |
no annotation | 5 | VAL A 660TYR A 652GLY A 721SER A 537GLY A 535 | None | 1.04A | 4mm8A-6gh2A:undetectable | 4mm8A-6gh2A:11.22 |