SIMILAR PATTERNS OF AMINO ACIDS FOR 4MM7_A_29JA603_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1c MAJOR COAT PROTEIN

(Saccharomyces
cerevisiae
virus L-A) 		PF09220
(LA-virus_coat) 		5 VAL A  32
TYR A  47
PHE A 474
SER A 469
THR A 591
 None
 1.23A 4mm7A-1m1cA:
0.0		 4mm7A-1m1cA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6u TRYPTOPHANYL-TRNA
SYNTHETASE

(Homo sapiens) 		PF00579
(tRNA-synt_1b) 		5 TYR A 100
VAL A  90
PHE A 339
GLY A  97
ASP A  86
 None
 1.36A 4mm7A-1r6uA:
0.1		 4mm7A-1r6uA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r9h FK506 BINDING
PROTEIN FAMILY

(Caenorhabditis
elegans) 		PF00254
(FKBP_C) 		5 VAL A  16
SER A  92
GLY A  95
ASP A   7
THR A   9
 None
 1.27A 4mm7A-1r9hA:
undetectable		 4mm7A-1r9hA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s4f RNA-DEPENDENT RNA
POLYMERASE

(Pestivirus A) 		PF00998
(RdRP_3) 		5 TYR A 591
PHE A 547
SER A 554
ASP A 593
THR A 668
 None
 1.40A 4mm7A-1s4fA:
0.0		 4mm7A-1s4fA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9v GMP SYNTHASE

(Thermoplasma
acidophilum) 		PF00117
(GATase) 		5 ASP A   8
VAL A  65
TYR A  68
SER A  49
GLY A  82
 None
 0.99A 4mm7A-2a9vA:
undetectable		 4mm7A-2a9vA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cdp BETA-AGARASE 1

(Saccharophagus
degradans) 		PF03422
(CBM_6) 		5 TYR A  63
VAL A 108
PHE A  76
SER A  62
GLY A 105
 None
CL  A1144 ( 4.2A)
None
None
EDO  A1141 (-4.0A)
 1.03A 4mm7A-2cdpA:
undetectable		 4mm7A-2cdpA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cjq RNA-DIRECTED RNA
POLYMERASE

(Pestivirus A) 		PF00998
(RdRP_3) 		5 TYR A 591
PHE A 547
SER A 554
ASP A 593
THR A 668
 None
 1.45A 4mm7A-2cjqA:
0.0		 4mm7A-2cjqA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0p ENDOGLUCANASE

(Ruminiclostridium
thermocellum) 		PF12891
(Glyco_hydro_44) 		5 TYR A 387
SER A  24
GLY A 385
ASP A 281
THR A 358
 None
 1.42A 4mm7A-2e0pA:
0.0		 4mm7A-2e0pA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hdw HYPOTHETICAL PROTEIN
PA2218

(Pseudomonas
aeruginosa) 		PF02129
(Peptidase_S15) 		5 TYR A 116
ASP A 349
TYR A 263
SER A 112
GLY A 103
 None
 1.49A 4mm7A-2hdwA:
undetectable		 4mm7A-2hdwA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iht CARBOXYETHYLARGININE
SYNTHASE

(Streptomyces
clavuligerus) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 ASP A 409
VAL A  62
PHE A  58
ASP A  98
THR A  94
 None
 1.20A 4mm7A-2ihtA:
undetectable		 4mm7A-2ihtA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lle CHEMOTAXIS PROTEIN
CHEY, IMIDAZOLE
GLYCEROL PHOSPHATE
SYNTHASE SUBUNIT
HISF CHIMERA

(Thermotoga
maritima) 		PF00072
(Response_reg)
PF00977
(His_biosynth) 		5 TYR A 161
VAL A 205
PHE A 189
SER A 180
GLY A 182
 None
 1.42A 4mm7A-2lleA:
undetectable		 4mm7A-2lleA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wan PULLULANASE

(Bacillus
acidopullulyticus) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 VAL A 331
TYR A 380
SER A 360
GLY A 363
ASP A 393
 None
 1.50A 4mm7A-2wanA:
0.0		 4mm7A-2wanA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wvl MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE

(Thermus
thermophilus) 		PF09488
(Osmo_MPGsynth) 		5 ASP A 290
VAL A 298
TYR A 282
GLY A  13
THR A 192
 None
 1.50A 4mm7A-2wvlA:
undetectable		 4mm7A-2wvlA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lqz HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DP ALPHA 1
CHAIN

(Homo sapiens) 		PF00993
(MHC_II_alpha)
PF07654
(C1-set) 		5 VAL A  42
TYR A  33
SER A  53
GLY A  49
ASP A  35
 None
 1.46A 4mm7A-3lqzA:
undetectable		 4mm7A-3lqzA:
15.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mpn TRANSPORTER

(Aquifex
aeolicus) 		PF00209
(SNF) 		6 VAL A 104
TYR A 107
TYR A 108
PHE A 259
SER A 355
ASP A 404
 None
None
LEU  A 601 (-4.5A)
LEU  A 601 (-3.6A)
NA  A 751 ( 2.3A)
None
 0.41A 4mm7A-3mpnA:
60.6		 4mm7A-3mpnA:
97.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pf2 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF16569
(GramPos_pilinBB)
PF16570
(GramPos_pilinD3) 		5 TYR A 454
SER A 490
GLY A 381
ASP A 500
THR A 499
 None
 1.36A 4mm7A-3pf2A:
undetectable		 4mm7A-3pf2A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va7 KLLA0E08119P

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 ASP A 989
VAL A 931
GLY A 703
ASP A 929
THR A 642
 None
 1.28A 4mm7A-3va7A:
undetectable		 4mm7A-3va7A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wev L-LYSINE 6-OXIDASE

(Marinomonas
mediterranea) 		no annotation 5 VAL A 431
TYR A 429
GLY A 269
ASP A 433
THR A 436
 None
 1.21A 4mm7A-3wevA:
undetectable		 4mm7A-3wevA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wuf ENDO-1,4-BETA-XYLANA
SE A

(Streptomyces
sp.) 		PF00331
(Glyco_hydro_10) 		5 ASP A 208
VAL A 225
TYR A 206
PHE A 260
GLY A 237
 None
 1.28A 4mm7A-3wufA:
undetectable		 4mm7A-3wufA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hfo BIOGENIC
AMINE-BINDING
PROTEIN

(Rhodnius
prolixus) 		PF02087
(Nitrophorin) 		5 ASP A 179
VAL A  95
TYR A  71
SER A  60
ASP A  98
 None
 1.46A 4mm7A-4hfoA:
undetectable		 4mm7A-4hfoA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvc DEXTRANSUCRASE

(Leuconostoc
mesenteroides) 		PF02324
(Glyco_hydro_70) 		5 VAL A1902
TYR A1893
SER A1896
GLY A1899
THR A1977
 None
 1.21A 4mm7A-4tvcA:
undetectable		 4mm7A-4tvcA:
18.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster) 		PF00209
(SNF) 		7 ASP A  46
VAL A 120
TYR A 123
TYR A 124
SER A 421
GLY A 425
ASP A 475
 41U  A 605 ( 3.3A)
41U  A 605 (-4.2A)
None
41U  A 605 ( 3.8A)
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
None
 0.71A 4mm7A-4xnuA:
42.0		 4mm7A-4xnuA:
30.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5clw 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Homo sapiens) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		5 VAL A 145
TYR A 155
PHE A 110
SER A 148
GLY A  97
 None
 1.31A 4mm7A-5clwA:
undetectable		 4mm7A-5clwA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgk ACTIVE HELICASE

(Staphylococcus
aureus) 		PF06048
(DUF927) 		5 VAL A 261
SER A 225
GLY A 184
ASP A 263
THR A 308
 None
None
None
MG  A 702 ( 3.9A)
None
 1.31A 4mm7A-5dgkA:
undetectable		 4mm7A-5dgkA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dn6 ATP SYNTHASE SUBUNIT
ALPHA

(Paracoccus
denitrificans) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		5 VAL A 159
SER A 371
GLY A 349
ASP A 154
THR A 148
 None
 1.39A 4mm7A-5dn6A:
undetectable		 4mm7A-5dn6A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epg ALDEHYDE OXIDASE

(Homo sapiens) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 ASP A1093
VAL A1163
TYR A1161
SER A1265
GLY A1192
 None
 1.15A 4mm7A-5epgA:
undetectable		 4mm7A-5epgA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		5 ASP b 481
VAL b 488
GLY b 404
ASP b 152
THR b 400
 None
 1.44A 4mm7A-5gw5b:
undetectable		 4mm7A-5gw5b:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB

(Mus musculus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		5 ASP A 843
TYR A 734
SER A 841
GLY A 417
ASP A 869
 None
 1.46A 4mm7A-5hjrA:
undetectable		 4mm7A-5hjrA:
21.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i6z SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER

(Homo sapiens) 		PF00209
(SNF) 		7 TYR A  95
ASP A  98
TYR A 175
TYR A 176
SER A 438
GLY A 442
THR A 497
 None
 0.88A 4mm7A-5i6zA:
43.6		 4mm7A-5i6zA:
32.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2e GLUTAMATE RECEPTOR
IONOTROPIC,
DELTA-2,GLUTAMATE
RECEPTOR IONOTROPIC,
DELTA-2

(Rattus
norvegicus) 		PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 ASP A 476
VAL A 445
TYR A 486
SER A 479
THR A 447
 None
 1.36A 4mm7A-5l2eA:
undetectable		 4mm7A-5l2eA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5c PUTATIVE
DECARBOXYLASE
INVOLVED IN
DESFERRIOXAMINE
BIOSYNTHESIS

(Erwinia
amylovora) 		no annotation 5 VAL A 466
TYR A 104
PHE A 460
SER A  58
GLY A 463
 None
 1.20A 4mm7A-5o5cA:
undetectable		 4mm7A-5o5cA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2o TASTE RECEPTOR, TYPE
1, MEMBER 3

(Oryzias latipes) 		PF01094
(ANF_receptor) 		5 TYR B 467
TYR B 449
SER B 300
GLY B 322
ASP B 198
 None
None
ARG  B 951 ( 4.6A)
None
None
 1.43A 4mm7A-5x2oB:
undetectable		 4mm7A-5x2oB:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzu BETA-XYLANASE

(Bispora sp.
MEY-1) 		no annotation 5 ASP A 184
VAL A 201
TYR A 182
PHE A 238
GLY A 213
 None
 1.39A 4mm7A-5xzuA:
undetectable		 4mm7A-5xzuA:
10.28