SIMILAR PATTERNS OF AMINO ACIDS FOR 4MM6_A_29EA603_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ea9 CYCLOMALTODEXTRINASE

(Bacillus sp.
(in: Bacteria)) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		5 VAL C 189
ALA C 188
TYR C 134
PHE C 141
PHE C 191
 None
 1.33A 4mm6A-1ea9C:
0.0		 4mm6A-1ea9C:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hjv CHITINASE-3 LIKE
PROTEIN 1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		5 ASP A 330
ALA A 295
TYR A 296
VAL A 326
GLY A 262
 None
 1.33A 4mm6A-1hjvA:
undetectable		 4mm6A-1hjvA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i36 CONSERVED
HYPOTHETICAL PROTEIN
MTH1747

(Methanothermobacter
thermautotrophicus) 		PF03807
(F420_oxidored)
PF09130
(DUF1932) 		5 ASP A  86
VAL A  11
ALA A  12
SER A  62
GLY A   7
 None
NAP  A1350 (-3.8A)
None
None
NAP  A1350 (-3.4A)
 1.14A 4mm6A-1i36A:
0.4		 4mm6A-1i36A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1imh NUCLEAR FACTOR OF
ACTIVATED T CELLS 5

(Homo sapiens) 		PF00554
(RHD_DNA_bind)
PF16179
(RHD_dimer) 		5 VAL C 255
ALA C 270
TYR C 268
VAL C 229
GLY C 310
 None
 1.33A 4mm6A-1imhC:
undetectable		 4mm6A-1imhC:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ir6 EXONUCLEASE RECJ

(Thermus
thermophilus) 		PF01368
(DHH)
PF02272
(DHHA1) 		5 VAL A 369
ALA A 397
PHE A 410
PHE A 400
GLY A 393
 None
 1.23A 4mm6A-1ir6A:
undetectable		 4mm6A-1ir6A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lar PROTEIN (LAR)

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 VAL A1520
ALA A1396
PHE A1503
PHE A1532
GLY A1530
 None
 1.24A 4mm6A-1larA:
0.0		 4mm6A-1larA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lar PROTEIN (LAR)

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 VAL A1811
ALA A1685
PHE A1792
PHE A1823
GLY A1821
 None
 1.29A 4mm6A-1larA:
0.0		 4mm6A-1larA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mbm CHYMOTRYPSIN-LIKE
SERINE PROTEASE

(Equine
arteritis virus) 		PF05579
(Peptidase_S32) 		5 ASP A 119
PHE A  14
VAL A  15
SER A 122
GLY A  23
 None
 1.17A 4mm6A-1mbmA:
undetectable		 4mm6A-1mbmA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mbm CHYMOTRYPSIN-LIKE
SERINE PROTEASE

(Equine
arteritis virus) 		PF05579
(Peptidase_S32) 		5 VAL A 133
ALA A 123
VAL A  15
GLY A  23
THR A 135
 None
 1.32A 4mm6A-1mbmA:
undetectable		 4mm6A-1mbmA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfg D-HYDANTOINASE

(Ralstonia
pickettii) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		5 VAL A 362
ALA A 366
PHE A  50
VAL A 391
GLY A  52
 None
 1.32A 4mm6A-1nfgA:
0.0		 4mm6A-1nfgA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1np7 DNA PHOTOLYASE

(Synechocystis
sp. PCC 6803) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		5 TYR A 398
ALA A 300
TYR A 303
PHE A 295
GLY A 394
 None
 1.12A 4mm6A-1np7A:
0.1		 4mm6A-1np7A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rpm RECEPTOR PROTEIN
TYROSINE PHOSPHATASE
MU

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 VAL A1093
ALA A 970
PHE A1076
PHE A1105
GLY A1103
 None
 1.28A 4mm6A-1rpmA:
0.1		 4mm6A-1rpmA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhk HYPOTHETICAL PROTEIN
YQEU

(Bacillus
subtilis) 		PF04452
(Methyltrans_RNA) 		5 VAL A 172
ALA A 173
TYR A 174
GLY A 226
THR A 218
 None
 1.33A 4mm6A-1vhkA:
undetectable		 4mm6A-1vhkA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yfo RECEPTOR PROTEIN
TYROSINE PHOSPHATASE
ALPHA

(Mus musculus) 		PF00102
(Y_phosphatase) 		5 VAL A 431
ALA A 303
PHE A 414
PHE A 443
GLY A 441
 None
 1.17A 4mm6A-1yfoA:
undetectable		 4mm6A-1yfoA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9v GMP SYNTHASE

(Thermoplasma
acidophilum) 		PF00117
(GATase) 		5 ASP A   8
VAL A  65
TYR A  68
SER A  49
GLY A  82
 None
 0.99A 4mm6A-2a9vA:
undetectable		 4mm6A-2a9vA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfv HUMAN PROTEIN
TYROSINE PHOSPHATASE
RECEPTOR TYPE J

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 VAL A1237
ALA A1111
PHE A1218
PHE A1249
GLY A1247
 None
 1.26A 4mm6A-2cfvA:
undetectable		 4mm6A-2cfvA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dzq GENERAL
TRANSCRIPTION FACTOR
II-I REPEAT
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF02946
(GTF2I) 		5 TYR A  34
VAL A  46
PHE A  61
PHE A  16
VAL A  32
 None
 1.11A 4mm6A-2dzqA:
undetectable		 4mm6A-2dzqA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwn DIHYDROOROTASE

(Porphyromonas
gingivalis) 		PF01979
(Amidohydro_1) 		5 VAL A 358
ALA A 362
PHE A  56
VAL A 386
GLY A  58
 None
 1.23A 4mm6A-2gwnA:
undetectable		 4mm6A-2gwnA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjd RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE EPSILON

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 VAL A 333
ALA A 206
PHE A 316
PHE A 345
GLY A 343
 None
 1.21A 4mm6A-2jjdA:
undetectable		 4mm6A-2jjdA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nv5 PTPRD, PHOSPHATASE

(Rattus
norvegicus) 		PF00102
(Y_phosphatase) 		5 VAL A1422
ALA A1298
PHE A1405
PHE A1434
GLY A1432
 None
 1.25A 4mm6A-2nv5A:
undetectable		 4mm6A-2nv5A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ooq RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE T

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 VAL A1104
ALA A 981
PHE A1087
PHE A1116
GLY A1114
 None
 1.20A 4mm6A-2ooqA:
undetectable		 4mm6A-2ooqA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qa2 POLYKETIDE OXYGENASE
CABE

(Streptomyces) 		PF01494
(FAD_binding_3) 		5 VAL A  94
ALA A  93
PHE A  54
PHE A  63
THR A  99
 None
 1.06A 4mm6A-2qa2A:
undetectable		 4mm6A-2qa2A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qve TYROSINE AMINOMUTASE

(Streptomyces
globisporus) 		PF00221
(Lyase_aromatic) 		5 ALA A 413
TYR A 415
PHE A 398
VAL A 400
GLY A 409
 None
 1.23A 4mm6A-2qveA:
undetectable		 4mm6A-2qveA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5d O-GLCNACASE NAGJ

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C)
PF02838
(Glyco_hydro_20b)
PF07555
(NAGidase) 		5 TYR A 295
VAL A 254
PHE A 425
GLY A 256
THR A 212
 None
 1.14A 4mm6A-2v5dA:
undetectable		 4mm6A-2v5dA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7z HEAT SHOCK COGNATE
71 KDA PROTEIN

(Rattus
norvegicus) 		PF00012
(HSP70) 		5 ASP A 206
ALA A 180
VAL A 219
SER A 208
THR A 145
 None
 1.29A 4mm6A-2v7zA:
undetectable		 4mm6A-2v7zA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE

(Methanocaldococcus
jannaschii) 		PF00814
(Peptidase_M22)
PF01163
(RIO1) 		5 TYR A 221
ALA A 227
TYR A 190
TYR A 226
SER A 222
 None
 1.25A 4mm6A-2vwbA:
undetectable		 4mm6A-2vwbA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8z LIPASE

(Pseudomonas sp.
MIS38) 		PF00353
(HemolysinCabind) 		5 ALA A 237
TYR A 236
SER A 204
GLY A 210
THR A 282
 None
 1.21A 4mm6A-2z8zA:
undetectable		 4mm6A-2z8zA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3czp PUTATIVE
POLYPHOSPHATE KINASE
2

(Pseudomonas
aeruginosa) 		PF03976
(PPK2) 		5 TYR A 366
VAL A 300
ALA A 301
PHE A 393
SER A 364
 None
 1.26A 4mm6A-3czpA:
undetectable		 4mm6A-3czpA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dyj TALIN-1

(Mus musculus) 		no annotation 5 ASP A2029
VAL A2087
ALA A2090
VAL A1985
GLY A2092
 None
 1.25A 4mm6A-3dyjA:
undetectable		 4mm6A-3dyjA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fyq CG6831-PA (TALIN)

(Drosophila
melanogaster) 		no annotation 5 ASP A2038
VAL A2096
ALA A2099
VAL A1994
GLY A2101
 None
 1.20A 4mm6A-3fyqA:
undetectable		 4mm6A-3fyqA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3get HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Campylobacter
jejuni) 		PF00155
(Aminotran_1_2) 		5 ASP A  91
ALA A 122
TYR A 121
PHE A 115
VAL A 188
 LLP  A 226 ( 3.4A)
None
None
LLP  A 226 ( 3.7A)
None
 1.16A 4mm6A-3getA:
undetectable		 4mm6A-3getA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hqi SPECKLE-TYPE POZ
PROTEIN

(Homo sapiens) 		PF00651
(BTB)
PF00917
(MATH) 		5 VAL A 206
ALA A 207
PHE A 225
PHE A 251
VAL A 250
 None
 1.26A 4mm6A-3hqiA:
undetectable		 4mm6A-3hqiA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i36 VASCULAR PROTEIN
TYROSINE PHOSPHATASE
1

(Rattus
norvegicus) 		PF00102
(Y_phosphatase) 		5 VAL A1116
ALA A 990
PHE A1097
PHE A1128
GLY A1126
 None
 1.18A 4mm6A-3i36A:
undetectable		 4mm6A-3i36A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ift GLYCINE CLEAVAGE
SYSTEM H PROTEIN

(Mycobacterium
tuberculosis) 		PF01597
(GCV_H) 		5 ASP A 104
VAL A  52
ALA A  51
SER A  79
GLY A  49
 None
 1.24A 4mm6A-3iftA:
undetectable		 4mm6A-3iftA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kvn ESTERASE ESTA

(Pseudomonas
aeruginosa) 		no annotation 5 VAL X  90
ALA X  89
TYR X  93
PHE X  21
GLY X  19
 None
None
None
C8E  X 624 ( 4.0A)
None
 1.29A 4mm6A-3kvnX:
0.0		 4mm6A-3kvnX:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lbb PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.793

(Streptococcus
mutans) 		PF03061
(4HBT) 		5 PHE A  12
VAL A  25
SER A  55
GLY A  89
THR A  29
 None
 1.20A 4mm6A-3lbbA:
undetectable		 4mm6A-3lbbA:
14.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mpn TRANSPORTER

(Aquifex
aeolicus) 		PF00209
(SNF) 		6 VAL A 104
ALA A 105
TYR A 107
TYR A 108
PHE A 259
SER A 355
 None
None
None
LEU  A 601 (-4.5A)
LEU  A 601 (-3.6A)
NA  A 751 ( 2.3A)
 0.48A 4mm6A-3mpnA:
60.4		 4mm6A-3mpnA:
97.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvq SEMAPHORIN-7A

(Homo sapiens) 		PF01403
(Sema)
PF01437
(PSI)
PF13895
(Ig_2) 		5 ASP A 343
VAL A 262
ALA A 263
TYR A 241
VAL A 387
 None
 1.23A 4mm6A-3nvqA:
undetectable		 4mm6A-3nvqA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o66 GLYCINE
BETAINE/CARNITINE/CH
OLINE ABC
TRANSPORTER

(Staphylococcus
aureus) 		PF04069
(OpuAC) 		5 TYR A 183
VAL A 216
ALA A 217
PHE A 192
PHE A 194
 None
 1.08A 4mm6A-3o66A:
undetectable		 4mm6A-3o66A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o66 GLYCINE
BETAINE/CARNITINE/CH
OLINE ABC
TRANSPORTER

(Staphylococcus
aureus) 		PF04069
(OpuAC) 		5 TYR A 183
VAL A 216
PHE A 192
PHE A 194
VAL A 197
 None
 1.28A 4mm6A-3o66A:
undetectable		 4mm6A-3o66A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ouk PROBABLE CONSERVED
TRANSMEMBRANE
PROTEIN

(Mycobacterium
tuberculosis) 		no annotation 5 ASP A 163
VAL A 156
VAL A 117
SER A 159
GLY A 112
 None
 1.21A 4mm6A-3oukA:
undetectable		 4mm6A-3oukA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis) 		PF00348
(polyprenyl_synt) 		5 TYR A 220
ASP A 216
ALA A 285
VAL A 277
GLY A 282
 None
 1.31A 4mm6A-3pkoA:
undetectable		 4mm6A-3pkoA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3put HYPOTHETICAL
CONSERVED PROTEIN

(Rhizobium etli) 		PF08327
(AHSA1) 		5 ALA A  89
TYR A  88
TYR A  90
PHE A  11
SER A 100
 None
HEZ  A 167 (-4.5A)
None
None
None
 1.26A 4mm6A-3putA:
undetectable		 4mm6A-3putA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q75 FARNESYLTRANSFERASE
BETA SUBUNIT

(Cryptococcus
neoformans) 		PF00432
(Prenyltrans) 		5 ASP B  42
VAL B 386
ALA B 387
VAL B   9
GLY B 311
 None
 1.16A 4mm6A-3q75B:
undetectable		 4mm6A-3q75B:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qpf PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
pneumoniae) 		PF06824
(Glyco_hydro_125) 		5 ALA A 309
TYR A 311
PHE A 232
VAL A 235
GLY A 313
 None
None
None
EDO  A 436 ( 4.2A)
None
 1.22A 4mm6A-3qpfA:
undetectable		 4mm6A-3qpfA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zl8 UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D-ALANINE LIGASE

(Thermotoga
maritima) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 ASP A 203
ALA A 267
PHE A 218
GLY A 220
THR A 216
 None
 1.30A 4mm6A-3zl8A:
undetectable		 4mm6A-3zl8A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zmr CELLULASE (GLYCOSYL
HYDROLASE FAMILY 5)

(Bacteroides
ovatus) 		PF00150
(Cellulase)
PF13004
(BACON) 		5 TYR A 212
VAL A 236
ALA A 235
PHE A 292
VAL A 210
 None
 1.25A 4mm6A-3zmrA:
undetectable		 4mm6A-3zmrA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zrp SERINE-PYRUVATE
AMINOTRANSFERASE
(AGXT)

(Sulfolobus
solfataricus) 		PF00266
(Aminotran_5) 		5 VAL A 290
ALA A 291
VAL A 301
SER A 139
GLY A 141
 None
 1.32A 4mm6A-3zrpA:
undetectable		 4mm6A-3zrpA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyv AOX3

(Mus musculus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 ASP A1089
VAL A1159
TYR A1157
SER A1261
GLY A1187
 None
 1.10A 4mm6A-3zyvA:
undetectable		 4mm6A-3zyvA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bpc RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 VAL A1587
ALA A1463
PHE A1570
PHE A1599
GLY A1597
 None
 1.24A 4mm6A-4bpcA:
undetectable		 4mm6A-4bpcA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bpc RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 VAL A1878
ALA A1752
PHE A1859
PHE A1890
GLY A1888
 None
 1.29A 4mm6A-4bpcA:
undetectable		 4mm6A-4bpcA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cu8 GLYCOSIDE HYDROLASE
2

(Streptococcus
pneumoniae) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		5 VAL A 950
ALA A 951
TYR A 890
TYR A 888
GLY A 920
 None
None
EDO  A2026 ( 4.1A)
None
None
 1.04A 4mm6A-4cu8A:
undetectable		 4mm6A-4cu8A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g92 HAPE
TRANSCRIPTION FACTOR
HAPC (EUROFUNG)

(Aspergillus
nidulans) 		PF00808
(CBFD_NFYB_HMF) 		5 TYR B 119
PHE C 157
PHE C 120
VAL C 119
GLY C 116
 None
 1.31A 4mm6A-4g92B:
undetectable		 4mm6A-4g92B:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ikc PHOSPHOTIDYLINOSITOL
PHOSPHATASE PTPRQ

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 VAL A2877
ALA A2753
PHE A2860
PHE A2889
GLY A2887
 None
 1.28A 4mm6A-4ikcA:
undetectable		 4mm6A-4ikcA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ita SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE

(Synechococcus
sp. PCC 7002) 		PF00171
(Aldedh) 		5 TYR A 341
VAL A 321
ALA A 320
VAL A 364
SER A 314
 None
None
EDO  A 502 ( 4.2A)
None
None
 1.15A 4mm6A-4itaA:
undetectable		 4mm6A-4itaA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1

(Physcomitrella
patens) 		PF01156
(IU_nuc_hydro) 		5 VAL A  98
TYR A 244
TYR A 241
VAL A  55
GLY A 103
 None
 1.14A 4mm6A-4kpnA:
undetectable		 4mm6A-4kpnA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mq0 PARKIA BIGLOBOSA
LECTIN (PBL)

(Parkia
biglobosa) 		PF01419
(Jacalin) 		5 ASP A 355
ALA A 429
TYR A 432
GLY A 349
THR A 391
 None
None
MMA  A 502 (-3.8A)
None
None
 1.31A 4mm6A-4mq0A:
undetectable		 4mm6A-4mq0A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mrm GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 2

(Homo sapiens) 		PF01094
(ANF_receptor) 		5 VAL B 134
PHE B 354
VAL B  77
SER B  72
GLY B  74
 None
 1.10A 4mm6A-4mrmB:
undetectable		 4mm6A-4mrmB:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4muo UNCHARACTERIZED
PROTEIN YBIB

(Escherichia
coli) 		PF02885
(Glycos_trans_3N) 		5 TYR A  88
TYR A  63
PHE A 161
VAL A 158
THR A 189
 None
 1.32A 4mm6A-4muoA:
undetectable		 4mm6A-4muoA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nrq RNA DEMETHYLASE
ALKBH5

(Homo sapiens) 		PF13532
(2OG-FeII_Oxy_2) 		5 VAL A 191
ALA A 190
PHE A 134
VAL A 161
GLY A 136
 None
 0.82A 4mm6A-4nrqA:
undetectable		 4mm6A-4nrqA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5p UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF09994
(DUF2235) 		5 ASP A 102
ALA A 154
TYR A 157
SER A 106
GLY A 108
 None
 1.26A 4mm6A-4o5pA:
undetectable		 4mm6A-4o5pA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psp ALPHA-FUCOSIDASE
GH29

(Fusarium
graminearum) 		PF01120
(Alpha_L_fucos)
PF16757
(Fucosidase_C) 		5 ASP A 303
VAL A 167
ALA A 120
TYR A  32
GLY A  30
 GOL  A 622 (-2.6A)
None
None
None
None
 0.99A 4mm6A-4pspA:
undetectable		 4mm6A-4pspA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgk UNCHARACTERIZED
PROTEIN

(Yersinia pestis) 		PF07350
(DUF1479) 		5 PHE A 111
PHE A 395
VAL A 393
SER A 382
GLY A 380
 None
 1.18A 4mm6A-4rgkA:
undetectable		 4mm6A-4rgkA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rjw PORIN O

(Pseudomonas
aeruginosa) 		PF07396
(Porin_O_P) 		5 ASP A 116
VAL A 189
ALA A 162
TYR A 163
SER A 165
 None
 1.32A 4mm6A-4rjwA:
undetectable		 4mm6A-4rjwA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tpg PROTON:OLIGOPEPTIDE
SYMPORTER POT FAMILY

(Shewanella
oneidensis) 		PF00854
(PTR2) 		5 VAL A 405
PHE A 288
VAL A 367
GLY A 401
THR A 284
 None
 1.07A 4mm6A-4tpgA:
1.3		 4mm6A-4tpgA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvc DEXTRANSUCRASE

(Leuconostoc
mesenteroides) 		PF02324
(Glyco_hydro_70) 		5 VAL A1902
TYR A1893
SER A1896
GLY A1899
THR A1977
 None
 1.24A 4mm6A-4tvcA:
undetectable		 4mm6A-4tvcA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wny UNIVERSAL STRESS
PROTEIN

(Burkholderia
pseudomallei) 		PF00582
(Usp) 		5 ASP A  20
VAL A   7
ALA A   8
VAL A  67
SER A  16
 None
 1.32A 4mm6A-4wnyA:
undetectable		 4mm6A-4wnyA:
16.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster) 		PF00209
(SNF) 		6 ASP A  46
TYR A 124
PHE A 325
VAL A 327
SER A 421
GLY A 425
 41U  A 605 ( 3.3A)
41U  A 605 ( 3.8A)
41U  A 605 ( 4.7A)
None
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
 0.77A 4mm6A-4xnuA:
40.4		 4mm6A-4xnuA:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster) 		PF00209
(SNF) 		5 ASP A  46
TYR A 124
VAL A 327
SER A 421
GLY A 424
 41U  A 605 ( 3.3A)
41U  A 605 ( 3.8A)
None
NA  A 602 ( 2.4A)
None
 0.94A 4mm6A-4xnuA:
40.4		 4mm6A-4xnuA:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster) 		PF00209
(SNF) 		7 ASP A  46
VAL A 120
TYR A 123
TYR A 124
VAL A 327
SER A 421
GLY A 425
 41U  A 605 ( 3.3A)
41U  A 605 (-4.2A)
None
41U  A 605 ( 3.8A)
None
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
 0.69A 4mm6A-4xnuA:
40.4		 4mm6A-4xnuA:
30.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zo6 LIN1840 PROTEIN

(Listeria
innocua) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 ASP A 404
TYR A 439
PHE A 527
VAL A 421
SER A 402
 None
 1.18A 4mm6A-4zo6A:
undetectable		 4mm6A-4zo6A:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxl O-GLCNACASE NAGJ

(Clostridium
perfringens) 		PF02838
(Glyco_hydro_20b)
PF07555
(NAGidase) 		5 TYR A 295
VAL A 254
PHE A 425
GLY A 256
THR A 212
 None
 1.15A 4mm6A-4zxlA:
undetectable		 4mm6A-4zxlA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cc2 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		5 ASP A  38
VAL A   7
TYR A  48
SER A  41
THR A   9
 None
None
CL  A 305 (-4.0A)
None
None
 1.14A 4mm6A-5cc2A:
undetectable		 4mm6A-5cc2A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
5
ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
8

(Homo sapiens) 		PF00005
(ABC_tran)
PF01061
(ABC2_membrane) 		5 TYR A 424
TYR B 567
PHE B 453
VAL A 542
GLY A 428
 None
 0.95A 4mm6A-5do7A:
undetectable		 4mm6A-5do7A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epg ALDEHYDE OXIDASE

(Homo sapiens) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 ASP A1093
VAL A1163
TYR A1161
SER A1265
GLY A1192
 None
 0.99A 4mm6A-5epgA:
undetectable		 4mm6A-5epgA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ha8 ISOCHORISMATASE

(Microbacterium
hydrocarbonoxydans) 		PF00857
(Isochorismatase) 		5 VAL A 129
ALA A 132
VAL A 112
GLY A 105
THR A 127
 None
 1.33A 4mm6A-5ha8A:
undetectable		 4mm6A-5ha8A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hcc COMPLEMENT C5

(Homo sapiens) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF07677
(A2M_recep)
PF07678
(A2M_comp) 		5 VAL A1423
ALA A1422
TYR A1496
TYR A1498
SER A1007
 None
 1.23A 4mm6A-5hccA:
undetectable		 4mm6A-5hccA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hee PUTATIVE
UNCHARACTERIZED
PROTEIN, TK2203
PROTEIN

(Thermococcus
kodakarensis) 		PF02900
(LigB) 		5 ALA A 176
TYR A 183
PHE A  70
PHE A 252
GLY A 174
 None
 1.17A 4mm6A-5heeA:
undetectable		 4mm6A-5heeA:
19.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i6z SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER

(Homo sapiens) 		PF00209
(SNF) 		6 TYR A  95
ASP A  98
ALA A 169
VAL A 343
SER A 438
GLY A 442
 None
 1.16A 4mm6A-5i6zA:
41.8		 4mm6A-5i6zA:
32.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i6z SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER

(Homo sapiens) 		PF00209
(SNF) 		9 TYR A  95
ASP A  98
ALA A 173
TYR A 175
TYR A 176
VAL A 343
SER A 438
GLY A 442
THR A 497
 None
 0.96A 4mm6A-5i6zA:
41.8		 4mm6A-5i6zA:
32.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iki CYTOCHROME P450(MEG)

(Bacillus
megaterium) 		PF00067
(p450) 		5 ASP A 231
ALA A 192
TYR A 195
TYR A 196
THR A 237
 None
 1.26A 4mm6A-5ikiA:
undetectable		 4mm6A-5ikiA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ilt BOVINE FAB A01 HEAVY
CHAIN

(Bos taurus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 235
PHE H 246
VAL H 263
SER H 178
GLY H 192
 None
 1.32A 4mm6A-5iltH:
undetectable		 4mm6A-5iltH:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jen ANTI-SIGMA-V FACTOR
RSIV
LYSOZYME C

(Bacillus
subtilis;
Gallus gallus) 		PF00062
(Lys)
PF11738
(DUF3298)
PF13739
(DUF4163) 		5 ASP A 253
VAL B 109
ALA B 110
GLY A 260
THR A 164
 NA  A 400 ( 3.9A)
None
None
NA  A 401 ( 4.7A)
None
 1.06A 4mm6A-5jenA:
undetectable		 4mm6A-5jenA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jmv PROBABLE
BIFUNCTIONAL TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN

(Methanocaldococcus
jannaschii) 		PF00814
(Peptidase_M22) 		5 TYR A 221
ALA A 227
TYR A 190
TYR A 226
SER A 222
 None
 1.21A 4mm6A-5jmvA:
1.7		 4mm6A-5jmvA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzm TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Francisella
tularensis) 		PF00290
(Trp_syntA) 		5 ASP A  39
TYR A  93
VAL A 260
SER A  43
GLY A  45
 None
 1.29A 4mm6A-5kzmA:
undetectable		 4mm6A-5kzmA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l7v GLYCOSIDE HYDROLASE

(Bacteroides
vulgatus) 		PF13320
(DUF4091) 		5 TYR A 491
VAL A 130
ALA A 131
SER A 497
THR A 106
 None
 1.22A 4mm6A-5l7vA:
undetectable		 4mm6A-5l7vA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzo UDP-GLUCOSE-GLYCOPRO
TEIN
GLUCOSYLTRANSFERASE-
LIKE PROTEIN

(Chaetomium
thermophilum) 		PF06427
(UDP-g_GGTase) 		5 VAL A 517
ALA A 529
TYR A 532
VAL A 480
SER A 536
 None
 1.28A 4mm6A-5mzoA:
undetectable		 4mm6A-5mzoA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nns GLYCOSYL HYDROLASE
FAMILY 61, 2 PROTEIN

(Heterobasidion
irregulare) 		no annotation 5 VAL A 175
ALA A  66
PHE A 107
SER A 143
GLY A 178
 None
 1.26A 4mm6A-5nnsA:
undetectable		 4mm6A-5nnsA:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nzz TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1

(Homo sapiens) 		no annotation 5 TYR A 250
TYR A 246
VAL A  76
SER A 163
GLY A 165
 None
 1.30A 4mm6A-5nzzA:
2.9		 4mm6A-5nzzA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5c PUTATIVE
DECARBOXYLASE
INVOLVED IN
DESFERRIOXAMINE
BIOSYNTHESIS

(Erwinia
amylovora) 		no annotation 5 VAL A 466
ALA A 465
TYR A 104
PHE A 460
SER A  58
 None
 1.27A 4mm6A-5o5cA:
undetectable		 4mm6A-5o5cA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5c PUTATIVE
DECARBOXYLASE
INVOLVED IN
DESFERRIOXAMINE
BIOSYNTHESIS

(Erwinia
amylovora) 		no annotation 5 VAL A 466
ALA A 465
TYR A 104
SER A  58
GLY A 463
 None
 1.27A 4mm6A-5o5cA:
undetectable		 4mm6A-5o5cA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqp CONDENSIN COMPLEX
SUBUNIT 3

(Saccharomyces
cerevisiae) 		no annotation 5 ASP A  59
VAL A  17
ALA A  18
PHE A 114
PHE A  54
 None
 1.11A 4mm6A-5oqpA:
2.6		 4mm6A-5oqpA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ucy TUBULIN ALPHA CHAIN

(Tetrahymena
thermophila) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		5 VAL A 375
ALA A 374
TYR A 319
PHE A 296
THR A 292
 None
 1.32A 4mm6A-5ucyA:
undetectable		 4mm6A-5ucyA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5usd PEPTIDASE S66

(Bacillus
anthracis) 		PF02016
(Peptidase_S66) 		5 ALA A 293
TYR A 188
PHE A 226
SER A 296
GLY A 263
 None
 1.08A 4mm6A-5usdA:
undetectable		 4mm6A-5usdA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6r GENOME POLYPROTEIN

(Pestivirus C) 		no annotation 5 ALA A 425
TYR A 424
PHE A  55
GLY A 466
THR A 181
 None
 1.11A 4mm6A-5y6rA:
undetectable		 4mm6A-5y6rA:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yvs ALCOHOL
DEHYDROGENASE

(candidate
divison MSBL1
archaeon
SCGC-AAA259E19) 		no annotation 5 ALA A 260
TYR A 259
PHE A  14
SER A 150
GLY A 153
 None
 1.18A 4mm6A-5yvsA:
undetectable		 4mm6A-5yvsA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zby HYDROGENASE
MATURATION PROTEASE
HYCI

(Thermococcus
kodakarensis) 		no annotation 5 VAL A  33
ALA A  34
PHE A  85
PHE A  29
GLY A  18
 None
 1.25A 4mm6A-5zbyA:
undetectable		 4mm6A-5zbyA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B

(Pyrococcus
furiosus) 		no annotation 5 PHE E  65
PHE F  81
VAL F  80
GLY F  77
THR E  72
 None
 1.07A 4mm6A-6cfwE:
undetectable		 4mm6A-6cfwE:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eic MYCOBACTERIUM
TUBERCULOSIS
MONOGLYCERIDE LIPASE

(Mycobacterium
tuberculosis) 		no annotation 5 VAL C 137
ALA C 136
PHE C 117
VAL C 116
GLY C 113
 None
SO4  C 301 ( 4.0A)
None
None
None
 0.93A 4mm6A-6eicC:
undetectable		 4mm6A-6eicC:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f6e RIBONUCLEOTIDE
REDUCTASE SMALL
SUBUNIT

(Geobacillus
kaustophilus) 		no annotation 5 VAL A  62
ALA A  63
PHE A 188
PHE A 178
SER A  57
 None
 1.29A 4mm6A-6f6eA:
undetectable		 4mm6A-6f6eA:
8.33