SIMILAR PATTERNS OF AMINO ACIDS FOR 4MM5_A_SREA603_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5l UREASE (ALPHA
SUBUNIT)

(Klebsiella
aerogenes) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		5 VAL C 421
ALA C 418
GLY C 192
PHE C 491
GLY C 416
 None
 1.16A 4mm5A-1a5lC:
0.0		 4mm5A-1a5lC:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bev BOVINE ENTEROVIRUS
COAT PROTEINS VP1 TO
VP4

(Enterovirus E) 		PF00073
(Rhv) 		5 ALA 1 254
GLY 3  63
PHE 2 156
SER 1 268
GLY 1 266
 None
 0.93A 4mm5A-1bev1:
undetectable		 4mm5A-1bev1:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1biy LACTOFERRIN

(Bubalus bubalis) 		PF00405
(Transferrin) 		5 VAL A 540
ALA A 541
GLY A 453
SER A 490
GLY A 538
 None
 1.21A 4mm5A-1biyA:
0.0		 4mm5A-1biyA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbi AK.1 SERINE PROTEASE

(Bacillus sp.
Ak1) 		PF00082
(Peptidase_S8) 		5 ASP A  48
VAL A 211
ALA A 220
TYR A 219
GLY A  92
 CA  A 701 (-2.2A)
None
None
None
None
 1.15A 4mm5A-1dbiA:
0.0		 4mm5A-1dbiA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8v MATURE CAPSID
PROTEIN BETA
MATURE CAPSID
PROTEIN GAMMA

(Pariacoto virus) 		PF01829
(Peptidase_A6)
no annotation 		5 PRO A 353
VAL A 356
ALA A 355
TYR A 240
GLY D 367
 None
 1.30A 4mm5A-1f8vA:
0.0		 4mm5A-1f8vA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz7 LIPASE 2

(Diutina rugosa) 		PF00135
(COesterase) 		5 PRO A  65
VAL A 296
ALA A 298
PHE A  87
GLY A  67
 None
None
NAG  A1536 ( 4.6A)
None
None
 1.12A 4mm5A-1gz7A:
undetectable		 4mm5A-1gz7A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i36 CONSERVED
HYPOTHETICAL PROTEIN
MTH1747

(Methanothermobacter
thermautotrophicus) 		PF03807
(F420_oxidored)
PF09130
(DUF1932) 		5 ASP A  86
VAL A  11
ALA A  12
SER A  62
GLY A   7
 None
NAP  A1350 (-3.8A)
None
None
NAP  A1350 (-3.4A)
 1.17A 4mm5A-1i36A:
undetectable		 4mm5A-1i36A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7j PROTEIN YCIO

(Escherichia
coli) 		PF01300
(Sua5_yciO_yrdC) 		5 ASP A 156
ALA A  39
GLY A 175
SER A 155
GLY A  37
 None
 1.19A 4mm5A-1k7jA:
undetectable		 4mm5A-1k7jA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1j FIBRINOGEN BETA
CHAIN

(Gallus gallus) 		PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		5 ASP B 246
VAL B 243
TYR B 244
GLY B 253
SER B 227
 None
 1.18A 4mm5A-1m1jB:
undetectable		 4mm5A-1m1jB:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n76 LACTOFERRIN

(Homo sapiens) 		PF00405
(Transferrin) 		5 VAL A 542
ALA A 543
GLY A 455
SER A 492
GLY A 540
 None
 1.27A 4mm5A-1n76A:
undetectable		 4mm5A-1n76A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ox4 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
HISHF

(Saccharomyces
cerevisiae) 		PF00117
(GATase)
PF00977
(His_biosynth) 		5 VAL B 368
ALA B 367
TYR B 369
GLY B 443
GLY B 364
 None
None
None
None
SO4  B 804 (-3.8A)
 1.12A 4mm5A-1ox4B:
undetectable		 4mm5A-1ox4B:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sy7 CATALASE 1

(Neurospora
crassa) 		PF00199
(Catalase)
PF01965
(DJ-1_PfpI)
PF06628
(Catalase-rel) 		5 VAL A 671
TYR A 683
GLY A 647
PHE A 646
GLY A 684
 None
 1.33A 4mm5A-1sy7A:
undetectable		 4mm5A-1sy7A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tki TITIN

(Homo sapiens) 		PF00069
(Pkinase) 		5 ASP A 144
VAL A 191
ALA A 188
TYR A 187
GLY A 141
 None
 1.30A 4mm5A-1tkiA:
undetectable		 4mm5A-1tkiA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u9c APC35852

(Geobacillus
stearothermophilus) 		PF01965
(DJ-1_PfpI) 		5 VAL A 192
GLY A 184
PHE A 190
SER A 151
GLY A 200
 None
 1.13A 4mm5A-1u9cA:
undetectable		 4mm5A-1u9cA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uwi BETA-GALACTOSIDASE

(Sulfolobus
solfataricus) 		PF00232
(Glyco_hydro_1) 		5 VAL A 409
TYR A 422
GLY A 469
PHE A   4
GLY A 421
 None
 1.26A 4mm5A-1uwiA:
undetectable		 4mm5A-1uwiA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vl2 ARGININOSUCCINATE
SYNTHASE

(Thermotoga
maritima) 		PF00764
(Arginosuc_synth) 		5 PRO A 168
ALA A 162
TYR A 161
GLY A  53
GLY A 166
 None
 1.22A 4mm5A-1vl2A:
undetectable		 4mm5A-1vl2A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x4h RNA-BINDING PROTEIN
28

(Mus musculus) 		PF00076
(RRM_1) 		5 ASP A  26
VAL A  47
ALA A  60
SER A  24
GLY A  58
 None
 1.12A 4mm5A-1x4hA:
undetectable		 4mm5A-1x4hA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT

(Thermotoga
maritima) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC) 		5 ALA A 617
TYR A 614
GLY A 246
PHE A 247
GLY A 624
 None
 1.17A 4mm5A-1xjeA:
undetectable		 4mm5A-1xjeA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y0l CATALYTIC ANTIBODY
FAB 34E4 HEAVY CHAIN

(Homo sapiens;
Mus musculus) 		no annotation 5 PRO H  14
VAL H 111
ALA H  12
SER H  82
GLY H  16
 None
 1.18A 4mm5A-1y0lH:
undetectable		 4mm5A-1y0lH:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aj4 GALACTOKINASE

(Saccharomyces
cerevisiae) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		5 ASP A 217
VAL A 232
ALA A 240
GLY A 214
PHE A 234
 GLA  A 529 (-2.9A)
None
None
GLA  A 529 (-3.9A)
None
 1.21A 4mm5A-2aj4A:
undetectable		 4mm5A-2aj4A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cev PROTEIN (ARGINASE)

([Bacillus]
caldovelox) 		PF00491
(Arginase) 		5 ASP A 226
PRO A 274
ALA A 283
GLY A 239
GLY A  23
 MN  A 302 (-2.9A)
None
None
None
None
 1.25A 4mm5A-2cevA:
undetectable		 4mm5A-2cevA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cy8 D-PHENYLGLYCINE
AMINOTRANSFERASE

(Pseudomonas
stutzeri) 		PF00202
(Aminotran_3) 		5 ASP A 201
ALA A 231
GLY A 138
SER A 200
GLY A 235
 None
 1.07A 4mm5A-2cy8A:
undetectable		 4mm5A-2cy8A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dc0 PROBABLE AMIDASE

(Thermus
thermophilus) 		PF01425
(Amidase) 		5 PRO A 133
ALA A 144
GLY A  86
SER A 147
GLY A 126
 None
 1.21A 4mm5A-2dc0A:
undetectable		 4mm5A-2dc0A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e8y AMYX PROTEIN

(Bacillus
subtilis) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 ASP A 224
PRO A 284
VAL A 279
ALA A 287
GLY A 237
 None
GOL  A 761 (-4.0A)
None
None
GOL  A 761 (-3.7A)
 1.31A 4mm5A-2e8yA:
undetectable		 4mm5A-2e8yA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e8y AMYX PROTEIN

(Bacillus
subtilis) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 PRO A 284
VAL A 279
ALA A 287
TYR A 288
GLY A 237
 GOL  A 761 (-4.0A)
None
None
None
GOL  A 761 (-3.7A)
 1.22A 4mm5A-2e8yA:
undetectable		 4mm5A-2e8yA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fi0 CONSERVED DOMAIN
PROTEIN

(Streptococcus
pneumoniae) 		PF08984
(DUF1858) 		5 PRO A  14
VAL A  18
ALA A  16
GLY A  55
GLY A  47
 None
 1.32A 4mm5A-2fi0A:
undetectable		 4mm5A-2fi0A:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzg MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME/ENOLASE
SUPERFAMILY

(Rhodobacter
sphaeroides) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ASP A 277
VAL A 290
ALA A 291
GLY A 282
SER A 315
 None
 1.14A 4mm5A-2hzgA:
undetectable		 4mm5A-2hzgA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jz4 JASMONATE INDUCIBLE
PROTEIN ISOLOG

(Arabidopsis
thaliana) 		PF01419
(Jacalin) 		5 ASP A 169
VAL A 190
ALA A 189
GLY A 291
PHE A 290
 None
 1.30A 4mm5A-2jz4A:
undetectable		 4mm5A-2jz4A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nxo HYPOTHETICAL PROTEIN
SCO4506

(Streptomyces
coelicolor) 		PF02621
(VitK2_biosynth) 		5 VAL A 187
ALA A 186
GLY A 250
PHE A 249
GLY A  78
 None
 1.15A 4mm5A-2nxoA:
undetectable		 4mm5A-2nxoA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p7n PATHOGENICITY ISLAND
1 EFFECTOR PROTEIN

(Chromobacterium
violaceum) 		PF06511
(IpaD) 		5 ASP A 259
PRO A 267
VAL A 264
GLY A 274
GLY A 277
 None
 1.23A 4mm5A-2p7nA:
undetectable		 4mm5A-2p7nA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yun NOSTRIN

(Homo sapiens) 		PF14604
(SH3_9) 		5 PRO A  55
VAL A  59
ALA A  57
PHE A  54
GLY A  41
 None
 1.32A 4mm5A-2yunA:
undetectable		 4mm5A-2yunA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aje PUTATIVE
UNCHARACTERIZED
PROTEIN ST1526

(Sulfurisphaera
tokodaii) 		PF01300
(Sua5_yciO_yrdC)
PF03481
(SUA5) 		5 VAL A 294
ALA A 295
GLY A 317
PHE A 318
GLY A 324
 None
 1.09A 4mm5A-3ajeA:
undetectable		 4mm5A-3ajeA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aw5 MULTICOPPER OXIDASE

(Pyrobaculum
aerophilum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 ASP A  97
VAL A 153
ALA A 126
GLY A  95
GLY A 253
 None
 1.25A 4mm5A-3aw5A:
undetectable		 4mm5A-3aw5A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayf NITRIC OXIDE
REDUCTASE

(Geobacillus
stearothermophilus) 		PF00115
(COX1) 		5 VAL A 667
ALA A 666
TYR A 670
GLY A 306
PHE A 309
 None
 1.21A 4mm5A-3ayfA:
undetectable		 4mm5A-3ayfA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctd PUTATIVE ATPASE, AAA
FAMILY

(Prochlorococcus
marinus) 		PF12002
(MgsA_C)
PF16193
(AAA_assoc_2) 		6 ASP A 311
VAL A 318
ALA A 340
TYR A 343
GLY A 308
SER A 347
 None
 1.44A 4mm5A-3ctdA:
undetectable		 4mm5A-3ctdA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dnf 4-HYDROXY-3-METHYLBU
T-2-ENYL DIPHOSPHATE
REDUCTASE

(Aquifex
aeolicus) 		PF02401
(LYTB) 		5 VAL A  20
ALA A  19
GLY A  11
PHE A  12
GLY A  15
 None
None
None
None
F3S  A2302 (-3.4A)
 1.22A 4mm5A-3dnfA:
undetectable		 4mm5A-3dnfA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ed4 ARYLSULFATASE

(Escherichia
coli) 		PF00884
(Sulfatase) 		5 VAL A 192
ALA A 246
GLY A 272
PHE A 270
SER A 243
 None
 1.24A 4mm5A-3ed4A:
undetectable		 4mm5A-3ed4A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fd5 SELENIDE, WATER
DIKINASE 1

(Homo sapiens) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 VAL A 302
ALA A 305
GLY A  28
PHE A 310
GLY A 307
 None
 1.19A 4mm5A-3fd5A:
undetectable		 4mm5A-3fd5A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fys PROTEIN DEGV

(Bacillus
subtilis) 		PF02645
(DegV) 		5 PRO A 226
VAL A 254
TYR A 251
SER A 222
GLY A 224
 None
 1.04A 4mm5A-3fysA:
undetectable		 4mm5A-3fysA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hly FLAVODOXIN-LIKE
DOMAIN

(Synechococcus
elongatus) 		no annotation 6 ASP A 275
PRO A 320
TYR A 267
GLY A 272
SER A 278
GLY A 318
 None
 1.40A 4mm5A-3hlyA:
undetectable		 4mm5A-3hlyA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ift GLYCINE CLEAVAGE
SYSTEM H PROTEIN

(Mycobacterium
tuberculosis) 		PF01597
(GCV_H) 		5 ASP A 104
VAL A  52
ALA A  51
SER A  79
GLY A  49
 None
 1.23A 4mm5A-3iftA:
undetectable		 4mm5A-3iftA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Thermus
thermophilus) 		PF01425
(Amidase) 		5 VAL E  65
ALA E  64
GLY E  73
SER E  40
GLY E 107
 None
 1.33A 4mm5A-3kfuE:
undetectable		 4mm5A-3kfuE:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lhf SERINE RECOMBINASE

(Sulfolobus
solfataricus) 		PF00239
(Resolvase) 		5 ASP A  91
PRO A 123
VAL A 120
ALA A 121
GLY A  95
 None
 1.03A 4mm5A-3lhfA:
undetectable		 4mm5A-3lhfA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdn GLUTAMINE
AMINOTRANSFERASE
CLASS-II DOMAIN
PROTEIN

(Ruegeria
pomeroyi) 		PF13230
(GATase_4) 		5 ASP A  50
VAL A  73
ALA A  74
GLY A  56
SER A  79
 None
 1.20A 4mm5A-3mdnA:
undetectable		 4mm5A-3mdnA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpl VIRULENCE SENSOR
PROTEIN BVGS

(Bordetella
pertussis) 		PF00497
(SBP_bac_3) 		5 VAL A 311
ALA A 312
GLY A 330
PHE A 329
GLY A 352
 None
 1.28A 4mm5A-3mplA:
undetectable		 4mm5A-3mplA:
19.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mpn TRANSPORTER

(Aquifex
aeolicus) 		PF00209
(SNF) 		6 PRO A 101
VAL A 104
ALA A 105
TYR A 108
PHE A 259
SER A 355
 None
None
None
LEU  A 601 (-4.5A)
LEU  A 601 (-3.6A)
NA  A 751 ( 2.3A)
 0.30A 4mm5A-3mpnA:
59.9		 4mm5A-3mpnA:
97.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pw3 AMINOPEPTIDASE C

(Parabacteroides
distasonis) 		PF03051
(Peptidase_C1_2) 		5 VAL A 284
ALA A 283
GLY A  33
PHE A  34
GLY A 281
 EDO  A 431 (-3.9A)
None
None
EDO  A 431 (-4.9A)
None
 1.02A 4mm5A-3pw3A:
undetectable		 4mm5A-3pw3A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t7b ACETYLGLUTAMATE
KINASE

(Yersinia pestis) 		PF00696
(AA_kinase) 		5 PRO A 230
VAL A 231
ALA A 224
GLY A 172
GLY A 228
 None
 1.21A 4mm5A-3t7bA:
undetectable		 4mm5A-3t7bA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN

(Escherichia
coli) 		PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		5 ASP A 360
ALA A 273
GLY A 222
SER A 374
GLY A 376
 None
 1.28A 4mm5A-3ttfA:
undetectable		 4mm5A-3ttfA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wj7 PUTATIVE
OXIDOREDUCTASE

(Gluconobacter
oxydans) 		PF01370
(Epimerase) 		5 ASP A 137
PRO A 178
VAL A 124
SER A 306
GLY A 240
 None
 1.33A 4mm5A-3wj7A:
undetectable		 4mm5A-3wj7A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wuf ENDO-1,4-BETA-XYLANA
SE A

(Streptomyces
sp.) 		PF00331
(Glyco_hydro_10) 		5 ASP A 208
VAL A 225
TYR A 206
PHE A 260
GLY A 237
 None
 1.21A 4mm5A-3wufA:
undetectable		 4mm5A-3wufA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13

(Mycobacterium
tuberculosis) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		5 VAL A 596
ALA A 482
TYR A 484
GLY A 567
GLY A 486
 None
 1.16A 4mm5A-3zukA:
undetectable		 4mm5A-3zukA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4au0 EXOGLUCANASE 2

(Trichoderma
reesei) 		PF01341
(Glyco_hydro_6) 		5 VAL A 127
ALA A 126
GLY A 374
PHE A 375
SER A 445
 None
 1.24A 4mm5A-4au0A:
undetectable		 4mm5A-4au0A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bn7 COPPER INDUCED
NITROREDUCTASE D

(Lactococcus
lactis) 		PF00881
(Nitroreductase) 		5 ALA A 142
GLY A  97
PHE A 179
SER A 181
GLY A 147
 None
 1.19A 4mm5A-4bn7A:
undetectable		 4mm5A-4bn7A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dz4 AGMATINASE

(Burkholderia
thailandensis) 		PF00491
(Arginase) 		5 ASP A 242
PRO A 289
ALA A 298
GLY A 255
GLY A  65
 MN  A 401 ( 2.8A)
EDO  A 405 ( 4.7A)
None
None
None
 1.32A 4mm5A-4dz4A:
undetectable		 4mm5A-4dz4A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ex4 MALATE SYNTHASE G

(Mycobacterium
leprae) 		PF01274
(Malate_synthase) 		5 ASP A 456
VAL A 459
ALA A 514
GLY A 430
SER A 101
 None
 1.31A 4mm5A-4ex4A:
undetectable		 4mm5A-4ex4A:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ezb UNCHARACTERIZED
CONSERVED PROTEIN

(Sinorhizobium
meliloti) 		PF03807
(F420_oxidored)
PF09130
(DUF1932) 		5 ASP A  96
ALA A  13
GLY A  74
SER A  70
GLY A   8
 None
 1.15A 4mm5A-4ezbA:
undetectable		 4mm5A-4ezbA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gn2 OXACILLINASE

(Pseudomonas
aeruginosa) 		PF00905
(Transpeptidase) 		5 PRO A  68
VAL A  71
ALA A  70
GLY A 135
PHE A 136
 KCX  A  66 ( 4.5A)
None
KCX  A  66 ( 3.5A)
None
None
 1.33A 4mm5A-4gn2A:
undetectable		 4mm5A-4gn2A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hz9 PUTATIVE CYTOPLASMIC
PROTEIN

(Ralstonia
pickettii) 		no annotation 5 VAL A  68
GLY A  55
PHE A  56
SER A  50
GLY A  48
 None
 1.33A 4mm5A-4hz9A:
undetectable		 4mm5A-4hz9A:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imm OUTER MEMBRANE
ASSEMBLY LIPOPROTEIN
YFGL

(Moraxella
catarrhalis) 		PF13360
(PQQ_2) 		5 PRO A 156
ALA A 157
GLY A 198
SER A 152
GLY A 113
 None
NA  A 404 (-4.5A)
MG  A 408 ( 3.6A)
None
None
 1.31A 4mm5A-4immA:
undetectable		 4mm5A-4immA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ni5 OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN

(Brucella suis) 		PF13561
(adh_short_C2) 		5 VAL A 178
ALA A 168
TYR A 171
GLY A 132
GLY A 172
 None
 1.31A 4mm5A-4ni5A:
undetectable		 4mm5A-4ni5A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ogq APOCYTOCHROME F

(Nostoc sp. PCC
7120) 		PF01333
(Apocytochr_F_C)
PF16639
(Apocytochr_F_N) 		5 ASP C 198
VAL C 225
ALA C 224
SER C 181
GLY C 222
 None
 1.15A 4mm5A-4ogqC:
undetectable		 4mm5A-4ogqC:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ohn ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF00497
(SBP_bac_3) 		5 ALA A  62
TYR A  61
GLY A  44
SER A  47
GLY A  53
 None
 1.06A 4mm5A-4ohnA:
undetectable		 4mm5A-4ohnA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psp ALPHA-FUCOSIDASE
GH29

(Fusarium
graminearum) 		PF01120
(Alpha_L_fucos)
PF16757
(Fucosidase_C) 		5 ASP A 303
VAL A 167
ALA A 120
TYR A  32
GLY A  30
 GOL  A 622 (-2.6A)
None
None
None
None
 1.10A 4mm5A-4pspA:
undetectable		 4mm5A-4pspA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0c VIRULENCE SENSOR
PROTEIN BVGS

(Bordetella
pertussis) 		PF00497
(SBP_bac_3) 		5 VAL A 311
ALA A 312
GLY A 330
PHE A 329
GLY A 352
 None
 1.25A 4mm5A-4q0cA:
undetectable		 4mm5A-4q0cA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qav 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Neisseria
meningitidis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 VAL A 351
ALA A 350
TYR A 352
GLY A 236
GLY A 346
 None
 1.27A 4mm5A-4qavA:
undetectable		 4mm5A-4qavA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiu NITRONATE
MONOOXYGENASE FAMILY
PROTEIN

(Pseudomonas
aeruginosa) 		PF03060
(NMO) 		5 VAL A  32
ALA A  31
GLY A 239
PHE A 242
SER A  24
 None
None
FMN  A 401 (-3.3A)
None
None
 1.03A 4mm5A-4qiuA:
undetectable		 4mm5A-4qiuA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Rhizobium etli) 		PF01547
(SBP_bac_1) 		5 VAL A 339
ALA A 340
GLY A 310
PHE A 144
SER A 146
 None
 1.26A 4mm5A-4rk2A:
undetectable		 4mm5A-4rk2A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rkk LAFORIN

(Homo sapiens) 		PF00686
(CBM_20)
PF00782
(DSPc) 		5 PRO A 246
VAL A 249
ALA A 248
GLY A 322
PHE A 317
 None
 1.15A 4mm5A-4rkkA:
undetectable		 4mm5A-4rkkA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usq PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE

(Cellvibrio sp.
BR) 		PF13738
(Pyr_redox_3) 		5 VAL A 286
ALA A 285
GLY A 150
PHE A 268
GLY A 156
 None
 1.13A 4mm5A-4usqA:
undetectable		 4mm5A-4usqA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xn3 TAIL SPIKE PROTEIN

(Salmonella
virus HK620) 		no annotation 5 ASP A 561
VAL A 615
ALA A 614
GLY A 556
PHE A 584
 None
 1.20A 4mm5A-4xn3A:
undetectable		 4mm5A-4xn3A:
21.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster) 		PF00209
(SNF) 		5 ASP A  46
GLY A 322
PHE A 325
SER A 421
GLY A 425
 41U  A 605 ( 3.3A)
41U  A 605 ( 4.1A)
41U  A 605 ( 4.7A)
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
 0.85A 4mm5A-4xnuA:
40.4		 4mm5A-4xnuA:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster) 		PF00209
(SNF) 		6 ASP A  46
VAL A 120
TYR A 124
GLY A 322
SER A 421
GLY A 425
 41U  A 605 ( 3.3A)
41U  A 605 (-4.2A)
41U  A 605 ( 3.8A)
41U  A 605 ( 4.1A)
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
 0.63A 4mm5A-4xnuA:
40.4		 4mm5A-4xnuA:
30.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awp ISOMALTODEXTRANASE

(Arthrobacter
globiformis) 		no annotation 5 VAL A 403
ALA A 393
GLY A 430
PHE A 420
SER A 400
 None
 1.32A 4mm5A-5awpA:
undetectable		 4mm5A-5awpA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3h PROTEIN SCARECROW

(Arabidopsis
thaliana) 		PF03514
(GRAS) 		5 VAL A 517
ALA A 648
GLY A 599
PHE A 600
GLY A 602
 None
 1.16A 4mm5A-5b3hA:
undetectable		 4mm5A-5b3hA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ce6 FACT-SPT16

(Cicer arietinum) 		PF00557
(Peptidase_M24)
PF14826
(FACT-Spt16_Nlob) 		5 VAL A  55
ALA A  54
GLY A 189
PHE A 190
GLY A 157
 None
 1.28A 4mm5A-5ce6A:
undetectable		 4mm5A-5ce6A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epg ALDEHYDE OXIDASE

(Homo sapiens) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 ASP A1093
VAL A1163
TYR A1161
SER A1265
GLY A1192
 None
 1.14A 4mm5A-5epgA:
undetectable		 4mm5A-5epgA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f83 BETA-LACTAMASE

(Pseudomonas
aeruginosa) 		PF13354
(Beta-lactamase2) 		5 PRO A  69
ALA A  71
GLY A  63
PHE A  66
SER A 125
 None
None
IM2  A 301 ( 3.9A)
None
IM2  A 301 (-2.7A)
 1.32A 4mm5A-5f83A:
undetectable		 4mm5A-5f83A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ham RICKCE

(Rickettsia
bellii) 		no annotation 5 ASP A 624
GLY A 656
PHE A 631
SER A 626
GLY A 629
 None
 1.02A 4mm5A-5hamA:
undetectable		 4mm5A-5hamA:
20.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i6z SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER

(Homo sapiens) 		PF00209
(SNF) 		6 ASP A  98
ALA A 173
TYR A 176
GLY A 338
SER A 438
GLY A 442
 None
 0.73A 4mm5A-5i6zA:
41.8		 4mm5A-5i6zA:
32.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iv8 LPS BIOSYNTHESIS
PROTEIN

(Klebsiella
pneumoniae) 		PF04453
(OstA_C) 		5 PRO A 336
VAL A 333
GLY A 352
PHE A 379
SER A 348
 None
 1.33A 4mm5A-5iv8A:
undetectable		 4mm5A-5iv8A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1c WD REPEAT-CONTAINING
PROTEIN 20

(Homo sapiens) 		PF00400
(WD40) 		5 ASP C 382
VAL C 288
ALA C 298
GLY C 370
GLY C 300
 None
 1.29A 4mm5A-5k1cC:
undetectable		 4mm5A-5k1cC:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqp GLYCOSIDE HYDROLASE
BT_1002

(Bacteroides
thetaiotaomicron) 		no annotation 5 VAL A 524
ALA A 525
TYR A 528
GLY A 464
GLY A 490
 None
 1.34A 4mm5A-5mqpA:
undetectable		 4mm5A-5mqpA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqp GLYCOSIDE HYDROLASE
BT_1002

(Bacteroides
thetaiotaomicron) 		no annotation 5 VAL A 524
TYR A 528
GLY A 464
SER A 492
GLY A 490
 None
 1.33A 4mm5A-5mqpA:
undetectable		 4mm5A-5mqpA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msw THIOESTER REDUCTASE
DOMAIN-CONTAINING
PROTEIN

(Segniliparus
rugosus) 		PF00501
(AMP-binding)
PF00550
(PP-binding) 		5 ASP A 141
VAL A 316
ALA A 317
PHE A 285
GLY A 321
 None
 1.30A 4mm5A-5mswA:
undetectable		 4mm5A-5mswA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ndl CRH-LIKE PROTEIN

(Aspergillus
fumigatus) 		no annotation 5 VAL A  74
ALA A  75
TYR A 228
GLY A 126
GLY A 231
 None
 1.22A 4mm5A-5ndlA:
undetectable		 4mm5A-5ndlA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5c PUTATIVE
DECARBOXYLASE
INVOLVED IN
DESFERRIOXAMINE
BIOSYNTHESIS

(Erwinia
amylovora) 		no annotation 5 VAL A 466
ALA A 465
PHE A 460
SER A  58
GLY A 463
 None
 1.31A 4mm5A-5o5cA:
undetectable		 4mm5A-5o5cA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t6o POLY-BETA-HYDROXYBUT
ERATE POLYMERASE

(Cupriavidus
necator) 		PF07167
(PhaC_N) 		5 ASP A 254
PRO A 579
ALA A 215
TYR A 228
GLY A 206
 None
 1.26A 4mm5A-5t6oA:
undetectable		 4mm5A-5t6oA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tu4 PAGF
PRENYLTRANSFERASE

(Planktothrix
agardhii) 		no annotation 5 VAL A 168
ALA A 187
GLY A 172
SER A 226
GLY A 224
 None
 1.33A 4mm5A-5tu4A:
undetectable		 4mm5A-5tu4A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj6 GLYCOSYL HYDROLASES
FAMILY 2, SUGAR
BINDING DOMAIN
PROTEIN

(Bacteroides
uniformis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF11721
(Malectin)
PF16355
(DUF4982) 		5 ASP A 154
ALA A 161
GLY A 171
SER A 113
GLY A 128
 None
 1.18A 4mm5A-5uj6A:
undetectable		 4mm5A-5uj6A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj6 GLYCOSYL HYDROLASES
FAMILY 2, SUGAR
BINDING DOMAIN
PROTEIN

(Bacteroides
uniformis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF11721
(Malectin)
PF16355
(DUF4982) 		5 ASP A 154
ALA A 161
GLY A 172
SER A 113
GLY A 128
 None
 1.33A 4mm5A-5uj6A:
undetectable		 4mm5A-5uj6A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqz GLUCAN-BINDING
PROTEIN C, GBPC

(Streptococcus
mutans) 		no annotation 5 PRO A 461
TYR A 423
GLY A 426
SER A 376
GLY A 374
 None
 1.27A 4mm5A-5uqzA:
undetectable		 4mm5A-5uqzA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5usd PEPTIDASE S66

(Bacillus
anthracis) 		PF02016
(Peptidase_S66) 		5 ALA A 293
TYR A 188
PHE A 226
SER A 296
GLY A 263
 None
 1.17A 4mm5A-5usdA:
undetectable		 4mm5A-5usdA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vrb TRANSKETOLASE

(Neisseria
gonorrhoeae) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 PRO A 426
VAL A 373
TYR A 401
SER A 376
GLY A 428
 None
 1.24A 4mm5A-5vrbA:
undetectable		 4mm5A-5vrbA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wab PUTATIVE
BETA-GLUCOSIDASE

(Bifidobacterium
adolescentis) 		no annotation 5 VAL A 102
ALA A 103
GLY A  45
SER A 151
GLY A 149
 None
 1.29A 4mm5A-5wabA:
undetectable		 4mm5A-5wabA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5weo GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF00822
(PMP22_Claudin)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 VAL A 530
ALA A 532
TYR A 533
SER A 537
GLY A 535
 None
 1.25A 4mm5A-5weoA:
undetectable		 4mm5A-5weoA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wi9 -

(-) 		no annotation 5 PRO A 242
VAL A 245
ALA A 246
TYR A 250
GLY A 270
 None
 1.16A 4mm5A-5wi9A:
undetectable		 4mm5A-5wi9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zby HYDROGENASE
MATURATION PROTEASE
HYCI

(Thermococcus
kodakarensis) 		no annotation 5 VAL A  33
ALA A  34
GLY A 124
PHE A  29
GLY A  18
 None
 1.06A 4mm5A-5zbyA:
undetectable		 4mm5A-5zbyA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ehn CARBOHYDRATE
ESTERASE MZ0003

(unidentified
prokaryotic
organism) 		no annotation 5 PRO A  20
VAL A 350
ALA A 349
TYR A 351
GLY A 346
 None
 1.26A 4mm5A-6ehnA:
undetectable		 4mm5A-6ehnA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eu6 AMMONIUM TRANSPORTER

(Candidatus
Kuenenia
stuttgartiensis) 		no annotation 5 PRO A 319
ALA A 322
GLY A  33
PHE A  34
GLY A 113
 None
 1.07A 4mm5A-6eu6A:
undetectable		 4mm5A-6eu6A:
10.48