SIMILAR PATTERNS OF AMINO ACIDS FOR 4MM4_B_8PRB603_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7j PROTEIN
(PARA-NITROBENZYL
ESTERASE)

(Bacillus
subtilis) 		PF00135
(COesterase) 		3 SER A 189
MET A 193
ASP A 360
 None
 0.91A 4mm4B-1c7jA:
undetectable		 4mm4B-1c7jA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f5a POLY(A) POLYMERASE

(Bos taurus) 		PF01909
(NTP_transf_2)
PF04926
(PAP_RNA-bind)
PF04928
(PAP_central) 		3 SER A 248
MET A 251
ASP A 115
 None
None
MN  A1002 (-2.6A)
 0.75A 4mm4B-1f5aA:
0.0		 4mm4B-1f5aA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f5n INTERFERON-INDUCED
GUANYLATE-BINDING
PROTEIN 1

(Homo sapiens) 		PF02263
(GBP)
PF02841
(GBP_C) 		3 SER A  52
MET A  55
ASP A 184
 MG  A 595 ( 2.2A)
None
GNP  A 593 (-2.9A)
 0.90A 4mm4B-1f5nA:
0.0		 4mm4B-1f5nA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gh6 LARGE T ANTIGEN

(Macaca mulatta
polyomavirus 1) 		no annotation 3 SER A  10
MET A  14
ASP A  64
 None
 0.91A 4mm4B-1gh6A:
undetectable		 4mm4B-1gh6A:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE

(Paenarthrobacter
aurescens) 		PF01979
(Amidohydro_1) 		3 SER A 341
MET A 345
ASP A 415
 None
 0.74A 4mm4B-1gkrA:
0.0		 4mm4B-1gkrA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mx3 C-TERMINAL BINDING
PROTEIN 1

(Homo sapiens) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		3 SER A 324
MET A 327
ASP A 130
 None
 0.91A 4mm4B-1mx3A:
0.0		 4mm4B-1mx3A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oyp RIBONUCLEASE PH

(Bacillus
subtilis) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		3 SER A  84
MET A  88
ASP A 117
 None
 0.93A 4mm4B-1oypA:
undetectable		 4mm4B-1oypA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1thg LIPASE 2

(Galactomyces
candidus) 		PF00135
(COesterase) 		3 SER A 217
MET A 221
ASP A 425
 None
 0.84A 4mm4B-1thgA:
0.0		 4mm4B-1thgA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ttx ONCOMODULIN

(Homo sapiens) 		PF13499
(EF-hand_7) 		3 SER A 109
MET A 106
ASP A  11
 None
 0.72A 4mm4B-1ttxA:
undetectable		 4mm4B-1ttxA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9b CONSERVED
HYPOTHETICAL PROTEIN

(Vibrio cholerae) 		PF08681
(DUF1778) 		3 SER A  31
MET A  29
ASP A  18
 None
 0.88A 4mm4B-1y9bA:
undetectable		 4mm4B-1y9bA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6t APOPTOTIC PROTEASE
ACTIVATING FACTOR 1

(Homo sapiens) 		PF00619
(CARD)
PF00931
(NB-ARC) 		3 SER A 371
MET A 368
ASP A 381
 None
 0.90A 4mm4B-1z6tA:
0.0		 4mm4B-1z6tA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a4d UBIQUITIN-CONJUGATIN
G ENZYME E2 VARIANT
1

(Homo sapiens) 		PF00179
(UQ_con) 		3 SER A 108
MET A 125
ASP A 114
 None
 0.92A 4mm4B-2a4dA:
undetectable		 4mm4B-2a4dA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b92 INTERFERON-INDUCED
GUANYLATE-BINDING
PROTEIN 1

(Homo sapiens) 		PF02263
(GBP)
PF02841
(GBP_C) 		3 SER A  52
MET A  55
ASP A 184
 SER  A  52 ( 0.0A)
MET  A  55 ( 0.0A)
ASP  A 184 (-0.6A)
 0.96A 4mm4B-2b92A:
0.0		 4mm4B-2b92A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw6 HYDROXYMETHYLGLUTARY
L-COA LYASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00682
(HMGL-like) 		3 SER A 219
MET A 222
ASP A 204
 None
 0.92A 4mm4B-2cw6A:
0.0		 4mm4B-2cw6A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpm PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1)

(Streptococcus
pneumoniae) 		PF02086
(MethyltransfD12) 		3 SER A 239
MET A 237
ASP A  62
 None
None
SAM  A 300 (-2.8A)
 0.88A 4mm4B-2dpmA:
undetectable		 4mm4B-2dpmA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7z ACETYLENE HYDRATASE
AHY

(Pelobacter
acetylenicus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		3 SER A 136
MET A 391
ASP A 705
 None
 0.86A 4mm4B-2e7zA:
undetectable		 4mm4B-2e7zA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gtx METHIONINE
AMINOPEPTIDASE

(Escherichia
coli) 		PF00557
(Peptidase_M24) 		3 SER A 110
MET A 112
ASP A  42
 None
 0.93A 4mm4B-2gtxA:
undetectable		 4mm4B-2gtxA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iyf OLEANDOMYCIN
GLYCOSYLTRANSFERASE

(Streptomyces
antibioticus) 		PF00201
(UDPGT) 		3 SER A  13
MET A  11
ASP A  47
 None
 0.82A 4mm4B-2iyfA:
undetectable		 4mm4B-2iyfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jcs DEOXYNUCLEOSIDE
KINASE

(Drosophila
melanogaster) 		PF01712
(dNK) 		3 SER A  91
MET A  88
ASP A 148
 None
 0.87A 4mm4B-2jcsA:
undetectable		 4mm4B-2jcsA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jp0 T-CELL SURFACE
GLYCOPROTEIN CD5

(Homo sapiens) 		PF00530
(SRCR) 		3 SER A 127
MET A  58
ASP A 123
 None
 0.97A 4mm4B-2jp0A:
undetectable		 4mm4B-2jp0A:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ome C-TERMINAL-BINDING
PROTEIN 2

(Homo sapiens) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		3 SER A 330
MET A 333
ASP A 136
 None
 0.91A 4mm4B-2omeA:
undetectable		 4mm4B-2omeA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p5d UPF0310 PROTEIN
MJECL36

(Methanocaldococcus
jannaschii) 		PF01878
(EVE) 		3 SER A 125
MET A 129
ASP A 140
 SER  A 125 ( 0.0A)
MET  A 129 ( 0.0A)
ASP  A 140 ( 0.6A)
 0.71A 4mm4B-2p5dA:
undetectable		 4mm4B-2p5dA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3o 12-OXOPHYTODIENOATE
REDUCTASE 3

(Arabidopsis
thaliana) 		PF00724
(Oxidored_FMN) 		3 SER A 320
MET A 318
ASP A 194
 FMN  A7401 ( 4.2A)
None
None
 0.81A 4mm4B-2q3oA:
undetectable		 4mm4B-2q3oA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qw5 XYLOSE
ISOMERASE-LIKE TIM
BARREL

(Trichormus
variabilis) 		PF01261
(AP_endonuc_2) 		3 SER A  84
MET A 126
ASP A 274
 None
 0.96A 4mm4B-2qw5A:
undetectable		 4mm4B-2qw5A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rb7 PEPTIDASE,
M20/M25/M40 FAMILY

(Desulfovibrio
alaskensis) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		3 SER A  55
MET A  57
ASP A 162
 None
PGE  A 364 ( 3.8A)
None
 0.93A 4mm4B-2rb7A:
undetectable		 4mm4B-2rb7A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rkv TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E

(Fusarium
graminearum) 		PF02458
(Transferase) 		3 SER A 410
MET A 412
ASP A 435
 None
 0.86A 4mm4B-2rkvA:
undetectable		 4mm4B-2rkvA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v2f PENICILLIN BINDING
PROTEIN 1A

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		3 SER F 331
MET F 593
ASP F 581
 None
 0.92A 4mm4B-2v2fF:
undetectable		 4mm4B-2v2fF:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3y VIRULENCE FACTOR

(Pectobacterium
carotovorum) 		no annotation 3 SER A 156
MET A 159
ASP A 259
 None
 0.96A 4mm4B-2w3yA:
undetectable		 4mm4B-2w3yA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzo TRANSFORMING GROWTH
FACTOR BETA
REGULATOR 1

(Homo sapiens) 		PF05964
(FYRN)
PF05965
(FYRC) 		3 SER A 276
MET A 279
ASP A 254
 GOL  A1325 (-2.6A)
None
None
 0.93A 4mm4B-2wzoA:
undetectable		 4mm4B-2wzoA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zu0 PROTEIN SUFD

(Escherichia
coli) 		PF01458
(UPF0051) 		3 SER A 306
MET A 337
ASP A 344
 None
 0.92A 4mm4B-2zu0A:
undetectable		 4mm4B-2zu0A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3adk ADENYLATE KINASE

(Sus scrofa) 		PF00406
(ADK) 		3 SER A  58
MET A  61
ASP A  74
 None
 0.97A 4mm4B-3adkA:
undetectable		 4mm4B-3adkA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ce9 GLYCEROL
DEHYDROGENASE

(Clostridium
acetobutylicum) 		PF13685
(Fe-ADH_2) 		3 SER A 128
MET A 236
ASP A 227
 None
 0.59A 4mm4B-3ce9A:
undetectable		 4mm4B-3ce9A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3deo SIGNAL RECOGNITION
PARTICLE 43 KDA
PROTEIN

(Arabidopsis
thaliana) 		PF12796
(Ank_2) 		3 SER A  92
MET A 100
ASP A 123
 None
 0.89A 4mm4B-3deoA:
undetectable		 4mm4B-3deoA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e5m NMRA-LIKE FAMILY
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF05368
(NmrA) 		3 SER A 177
MET A 241
ASP A 170
 None
 0.89A 4mm4B-3e5mA:
undetectable		 4mm4B-3e5mA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f3s LAMBDA-CRYSTALLIN
HOMOLOG

(Homo sapiens) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		3 SER A  20
MET A  23
ASP A  36
 None
None
NAD  A 601 (-2.7A)
 0.94A 4mm4B-3f3sA:
undetectable		 4mm4B-3f3sA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fwy LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE
IRON-SULFUR
ATP-BINDING PROTEIN

(Rhodobacter
sphaeroides) 		PF00142
(Fer4_NifH) 		3 SER A 183
MET A 187
ASP A  68
 None
None
MG  A 401 ( 4.5A)
 0.93A 4mm4B-3fwyA:
undetectable		 4mm4B-3fwyA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g9q FERRICHROME-BINDING
PROTEIN

(Bacillus
subtilis) 		PF01497
(Peripla_BP_2) 		3 SER A 193
MET A 195
ASP A 234
 None
 0.89A 4mm4B-3g9qA:
undetectable		 4mm4B-3g9qA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4z MALTOSE-BINDING
PERIPLASMIC PROTEIN
FUSED WITH ALLERGEN
DERP7

(Dermatophagoides
pteronyssinus;
Escherichia
coli) 		PF13416
(SBP_bac_8)
PF16984
(Grp7_allergen) 		3 SER A1133
MET A1114
ASP A1137
 None
 0.70A 4mm4B-3h4zA:
undetectable		 4mm4B-3h4zA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7m SENSOR PROTEIN

(Geobacter
sulfurreducens) 		PF00497
(SBP_bac_3) 		3 SER A 232
MET A 211
ASP A 159
 None
 0.92A 4mm4B-3h7mA:
undetectable		 4mm4B-3h7mA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iuy PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX53

(Homo sapiens) 		PF00270
(DEAD) 		3 SER A 416
MET A 414
ASP A 215
 None
 0.91A 4mm4B-3iuyA:
undetectable		 4mm4B-3iuyA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kio RIBONUCLEASE H2
SUBUNIT A

(Mus musculus) 		PF01351
(RNase_HII) 		3 SER A 103
MET A 106
ASP A  95
 None
 0.89A 4mm4B-3kioA:
undetectable		 4mm4B-3kioA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kya PUTATIVE PHOSPHATASE

(Bacteroides
thetaiotaomicron) 		PF01833
(TIG) 		3 SER A 494
MET A 479
ASP A 484
 None
 0.87A 4mm4B-3kyaA:
undetectable		 4mm4B-3kyaA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m62 UBIQUITIN
CONJUGATION FACTOR
E4

(Saccharomyces
cerevisiae) 		PF04564
(U-box)
PF10408
(Ufd2P_core) 		3 SER A 278
MET A 282
ASP A 198
 None
 0.92A 4mm4B-3m62A:
undetectable		 4mm4B-3m62A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mah ASPARTOKINASE

(Porphyromonas
gingivalis) 		PF13840
(ACT_7) 		3 SER A 320
MET A 324
ASP A 370
 None
 0.97A 4mm4B-3mahA:
undetectable		 4mm4B-3mahA:
16.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mpn TRANSPORTER

(Aquifex
aeolicus) 		PF00209
(SNF) 		3 SER A 356
MET A 360
ASP A 404
 None
 0.37A 4mm4B-3mpnA:
59.2		 4mm4B-3mpnA:
97.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8r GERANYLTRANSTRANSFER
ASE

(Vibrio cholerae) 		PF00348
(polyprenyl_synt) 		3 SER A 147
MET A 152
ASP A 207
 None
 0.97A 4mm4B-3p8rA:
undetectable		 4mm4B-3p8rA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pe8 ENOYL-COA HYDRATASE

(Mycolicibacterium
smegmatis) 		PF00378
(ECH_1) 		3 SER A  42
MET A  87
ASP A  49
 None
 0.91A 4mm4B-3pe8A:
undetectable		 4mm4B-3pe8A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3quf EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 1

(Bifidobacterium
longum) 		PF13416
(SBP_bac_8) 		3 SER A 273
MET A 271
ASP A 365
 None
 0.96A 4mm4B-3qufA:
undetectable		 4mm4B-3qufA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s8i PROTEIN DDI1 HOMOLOG
1

(Homo sapiens) 		PF09668
(Asp_protease) 		3 SER A 319
MET A 265
ASP A 323
 None
 0.98A 4mm4B-3s8iA:
undetectable		 4mm4B-3s8iA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1

(Mus musculus) 		PF00400
(WD40)
PF00931
(NB-ARC)
PF12894
(ANAPC4_WD40) 		3 SER A 371
MET A 368
ASP A 381
 None
 0.82A 4mm4B-3sfzA:
undetectable		 4mm4B-3sfzA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sut BETA-HEXOSAMINIDASE

(Paenibacillus
sp. TS12) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b) 		3 SER A 365
MET A 385
ASP A 321
 None
None
OAN  A2000 (-4.0A)
 0.96A 4mm4B-3sutA:
undetectable		 4mm4B-3sutA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t2n SERINE PROTEASE
HEPSIN

(Homo sapiens) 		PF00089
(Trypsin)
PF09272
(Hepsin-SRCR) 		3 SER A  89
MET A  93
ASP A  67
 None
 0.98A 4mm4B-3t2nA:
undetectable		 4mm4B-3t2nA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tt9 PLAKOPHILIN-2

(Homo sapiens) 		PF00514
(Arm) 		3 SER A 466
MET A 475
ASP A 428
 None
 0.85A 4mm4B-3tt9A:
undetectable		 4mm4B-3tt9A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w1s AUTOPHAGY PROTEIN 5

(Saccharomyces
cerevisiae) 		PF04106
(APG5) 		3 SER A 159
MET A 163
ASP A 274
 None
 0.93A 4mm4B-3w1sA:
undetectable		 4mm4B-3w1sA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a6u OMEGA TRANSAMINASE

(Chromobacterium
violaceum) 		PF00202
(Aminotran_3) 		3 SER A 424
MET A 415
ASP A 372
 None
 0.85A 4mm4B-4a6uA:
undetectable		 4mm4B-4a6uA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4apm APICAL MEMBRANE
ANTIGEN 1

(Babesia
divergens) 		PF02430
(AMA-1) 		3 SER A 340
MET A 343
ASP A 407
 None
 0.96A 4mm4B-4apmA:
undetectable		 4mm4B-4apmA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d59 CELL SURFACE PROTEIN
(PUTATIVE CELL
SURFACE-ASSOCIATED
CYSTEINE PROTEASE)

(Clostridioides
difficile) 		PF00112
(Peptidase_C1) 		3 SER A 118
MET A 122
ASP A 320
 None
 0.95A 4mm4B-4d59A:
undetectable		 4mm4B-4d59A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewf BETA-LACTAMASE

(Sphaerobacter
thermophilus) 		PF13354
(Beta-lactamase2) 		3 SER A 139
MET A 136
ASP A 125
 None
 0.97A 4mm4B-4ewfA:
undetectable		 4mm4B-4ewfA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3

(Legionella
pneumophila) 		no annotation 3 SER A 415
MET A 413
ASP A 553
 None
 0.95A 4mm4B-4fyeA:
undetectable		 4mm4B-4fyeA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		3 SER A 311
MET A 315
ASP A 344
 None
 0.93A 4mm4B-4hzsA:
undetectable		 4mm4B-4hzsA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 SER A 311
MET A 315
ASP A 344
 None
 0.65A 4mm4B-4id7A:
undetectable		 4mm4B-4id7A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1

(Haemonchus
contortus) 		PF08241
(Methyltransf_11) 		3 SER A  25
MET A 169
ASP A  39
 None
 0.90A 4mm4B-4krgA:
undetectable		 4mm4B-4krgA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lct COP9 SIGNALOSOME
COMPLEX SUBUNIT 1

(Arabidopsis
thaliana) 		PF01399
(PCI)
PF10602
(RPN7) 		3 SER A 186
MET A 189
ASP A 147
 None
 0.87A 4mm4B-4lctA:
undetectable		 4mm4B-4lctA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4le4 BETA-GLUCANASE

(Podospora
anserina) 		no annotation 3 SER A  32
MET A  30
ASP A  67
 None
 0.88A 4mm4B-4le4A:
undetectable		 4mm4B-4le4A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m46 LUCIFERASE

(Lampyris
turkestanicus) 		PF00501
(AMP-binding) 		3 SER A 347
MET A 396
ASP A 422
 None
 0.83A 4mm4B-4m46A:
undetectable		 4mm4B-4m46A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otk MYCOBACTERIAL ENZYME
RV2971

(Mycobacterium
tuberculosis) 		PF00248
(Aldo_ket_red) 		3 SER A  93
MET A 131
ASP A 102
 None
 0.82A 4mm4B-4otkA:
undetectable		 4mm4B-4otkA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlo HOMOSERINE
O-ACETYLTRANSFERASE

(Staphylococcus
aureus) 		PF00561
(Abhydrolase_1) 		3 SER A 131
MET A 135
ASP A 272
 None
 0.91A 4mm4B-4qloA:
undetectable		 4mm4B-4qloA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6i ANTHRAX TOXIN
EXPRESSION
TRANS-ACTING
POSITIVE REGULATOR

(Bacillus
anthracis) 		PF00874
(PRD)
PF05043
(Mga)
PF08279
(HTH_11) 		3 SER A 197
MET A 193
ASP A 166
 None
 0.95A 4mm4B-4r6iA:
undetectable		 4mm4B-4r6iA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r86 RND FAMILY
AMINOGLYCOSIDE/MULTI
DRUG EFFLUX PUMP

(Salmonella
enterica) 		PF00873
(ACR_tran) 		3 SER A  59
MET A  42
ASP A  65
 None
 0.82A 4mm4B-4r86A:
undetectable		 4mm4B-4r86A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tzo PROTEIN HTP-1

(Caenorhabditis
elegans) 		PF02301
(HORMA) 		3 SER A  38
MET A  42
ASP A 165
 None
 0.67A 4mm4B-4tzoA:
undetectable		 4mm4B-4tzoA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upk PHOSPHONATE
MONOESTER HYDROLASE

(Ruegeria
pomeroyi) 		PF00884
(Sulfatase) 		3 SER A 477
MET A 480
ASP A 453
 None
 0.82A 4mm4B-4upkA:
undetectable		 4mm4B-4upkA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y21 PROTEIN UNC-13
HOMOLOG A

(Rattus
norvegicus) 		PF06292
(DUF1041)
PF10540
(Membr_traf_MHD) 		3 SER A 164
MET A 168
ASP A  79
 None
 0.88A 4mm4B-4y21A:
undetectable		 4mm4B-4y21A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zcf RESTRICTION
ENDONUCLEASE
ECOP15I,
MODIFICATION SUBUNIT
RESTRICTION
ENDONUCLEASE
ECOP15I, RESTRICTION
SUBUNIT

(Escherichia
coli) 		PF01555
(N6_N4_Mtase)
PF04851
(ResIII) 		3 SER A 617
MET A 621
ASP C 750
 None
 0.92A 4mm4B-4zcfA:
undetectable		 4mm4B-4zcfA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cv1 P GRANULE
ABNORMALITY PROTEIN
1

(Caenorhabditis
elegans) 		no annotation 3 SER A 263
MET A 266
ASP A 405
 None
 0.88A 4mm4B-5cv1A:
undetectable		 4mm4B-5cv1A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dfa BETA-GALACTOSIDASE

(Geobacillus
stearothermophilus) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		3 SER A 346
MET A 350
ASP A 299
 None
 0.95A 4mm4B-5dfaA:
undetectable		 4mm4B-5dfaA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8h GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 3,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		3 SER A 138
MET A 146
ASP A  70
 None
 0.90A 4mm4B-5e8hA:
undetectable		 4mm4B-5e8hA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fr7 AMYR

(Erwinia
amylovora) 		PF10722
(YbjN) 		3 SER A 130
MET A 134
ASP A  47
 None
 0.94A 4mm4B-5fr7A:
undetectable		 4mm4B-5fr7A:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gyz LUCIFERIN
4-MONOOXYGENASE

(Photinus
pyralis) 		PF00501
(AMP-binding) 		3 SER A 347
MET A 396
ASP A 422
 7BV  A 500 (-2.3A)
None
AMP  A 501 (-2.7A)
 0.94A 4mm4B-5gyzA:
undetectable		 4mm4B-5gyzA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3w FIBRONECTIN/FIBRINOG
EN BINDING PROTEIN

(Streptococcus
suis) 		PF05670
(DUF814)
PF05833
(FbpA) 		3 SER A 123
MET A 127
ASP A 244
 None
 0.92A 4mm4B-5h3wA:
undetectable		 4mm4B-5h3wA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jpn COMPLEMENT C4-A

(Homo sapiens) 		PF01835
(A2M_N)
PF07703
(A2M_N_2) 		3 SER A 216
MET A 177
ASP A 221
 None
None
PBM  A 704 (-3.6A)
 0.90A 4mm4B-5jpnA:
undetectable		 4mm4B-5jpnA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jw6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Aspergillus
fumigatus) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 SER A 194
MET A 198
ASP A 249
 None
 0.97A 4mm4B-5jw6A:
undetectable		 4mm4B-5jw6A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbd TUMOR PROTEIN P73

(Homo sapiens) 		PF00870
(P53) 		3 SER A 260
MET A 266
ASP A 202
 None
 0.92A 4mm4B-5kbdA:
undetectable		 4mm4B-5kbdA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lkq DNA REPAIR PROTEIN
RADA

(Streptococcus
pneumoniae) 		PF13541
(ChlI) 		3 SER A 332
MET A 335
ASP A 362
 None
 0.92A 4mm4B-5lkqA:
undetectable		 4mm4B-5lkqA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdh MALATE DEHYDROGENASE

(Sus scrofa) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 SER A 152
MET A 268
ASP A 273
 None
 0.90A 4mm4B-5mdhA:
undetectable		 4mm4B-5mdhA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 3 SER A 202
MET A 200
ASP A  15
 None
 0.90A 4mm4B-5n4lA:
undetectable		 4mm4B-5n4lA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 3 SER A 236
MET A 239
ASP A  29
 NA  A1107 (-3.3A)
NA  A1107 ( 4.6A)
None
 0.90A 4mm4B-5n4lA:
undetectable		 4mm4B-5n4lA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n94 CG9323, ISOFORM A

(Drosophila
melanogaster) 		no annotation 3 SER A 692
MET A 690
ASP A 680
 None
 0.78A 4mm4B-5n94A:
undetectable		 4mm4B-5n94A:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5npy FLAGELLAR BASAL BODY
PROTEIN

(Helicobacter
pylori) 		no annotation 3 SER A 456
MET A 430
ASP A 203
 None
 0.74A 4mm4B-5npyA:
undetectable		 4mm4B-5npyA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5obu CHAPERONE PROTEIN
DNAK

(Mycoplasma
genitalium) 		no annotation 3 SER A 301
MET A 336
ASP A 184
 None
 0.91A 4mm4B-5obuA:
undetectable		 4mm4B-5obuA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oet GLUTATHIONE
SYNTHETASE-LIKE
EFFECTOR 30
(GPA-GSS30-APO)

(Globodera
pallida) 		no annotation 3 SER B 119
MET B 485
ASP B 149
 None
 0.73A 4mm4B-5oetB:
undetectable		 4mm4B-5oetB:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ue8 PROTEIN UNC-13
HOMOLOG A

(Rattus
norvegicus) 		PF00130
(C1_1)
PF00168
(C2)
PF06292
(DUF1041)
PF10540
(Membr_traf_MHD) 		3 SER A1096
MET A1100
ASP A1011
 None
 0.84A 4mm4B-5ue8A:
undetectable		 4mm4B-5ue8A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uow N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR1-8A

(Xenopus laevis) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		3 SER A 602
MET A 605
ASP A 579
 None
 0.98A 4mm4B-5uowA:
undetectable		 4mm4B-5uowA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3f TUBULIN ALPHA-1
CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		3 SER A 380
MET A 378
ASP A 206
 None
 0.66A 4mm4B-5w3fA:
undetectable		 4mm4B-5w3fA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wft PELB

(Pseudomonas
aeruginosa) 		no annotation 3 SER A 364
MET A 367
ASP A 326
 None
 0.83A 4mm4B-5wftA:
undetectable		 4mm4B-5wftA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wt3 TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A

(Pyrococcus
abyssi) 		no annotation 3 SER A 316
MET A 170
ASP A 328
 None
G  C  37 ( 4.4A)
None
 0.89A 4mm4B-5wt3A:
undetectable		 4mm4B-5wt3A:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ams BETA SLIDING CLAMP

(Pseudomonas
aeruginosa) 		no annotation 3 SER A 181
MET A 179
ASP A 354
 None
 0.80A 4mm4B-6amsA:
undetectable		 4mm4B-6amsA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b9g ATLASTIN-1

(Homo sapiens) 		no annotation 3 SER B  81
MET B  84
ASP B 218
 GDP  B 401 ( 2.5A)
None
GDP  B 401 (-2.7A)
 0.82A 4mm4B-6b9gB:
undetectable		 4mm4B-6b9gB:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfi VIN1

(Oscarella
pearsei) 		no annotation 3 SER A 496
MET A 500
ASP A 375
 None
 0.87A 4mm4B-6bfiA:
undetectable		 4mm4B-6bfiA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bi4 DTDP-GLUCOSE
4,6-DEHYDRATASE

(Bacillus
anthracis) 		no annotation 3 SER A 156
MET A 159
ASP A 126
 None
 0.76A 4mm4B-6bi4A:
undetectable		 4mm4B-6bi4A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f71 GLUTATHIONE
TRANSFERASE

(Trametes
versicolor) 		no annotation 3 SER A  13
MET A  11
ASP A  41
 None
 0.88A 4mm4B-6f71A:
undetectable		 4mm4B-6f71A:
8.63