SIMILAR PATTERNS OF AMINO ACIDS FOR 4MM4_B_8PRB603_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ay2 TYPE 4 PILIN

(Neisseria
gonorrhoeae) 		PF00114
(Pilin) 		5 ALA A  46
TYR A  50
VAL A  47
SER A  63
GLY A  65
 None
None
None
NAG  A 161 (-1.4A)
None
 1.20A 4mm4B-1ay2A:
undetectable		 4mm4B-1ay2A:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ef9 METHYLMALONYL COA
DECARBOXYLASE

(Escherichia
coli) 		PF00378
(ECH_1) 		5 ALA A 124
VAL A 184
PHE A  62
SER A  59
GLY A 105
 None
 1.15A 4mm4B-1ef9A:
undetectable		 4mm4B-1ef9A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkh GAMMA LACTAMASE

(Microbacterium) 		PF00561
(Abhydrolase_1) 		5 VAL A 195
ALA A 196
TYR A 198
VAL A 200
GLY A  60
 None
 1.15A 4mm4B-1hkhA:
undetectable		 4mm4B-1hkhA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkh GAMMA LACTAMASE

(Microbacterium) 		PF00561
(Abhydrolase_1) 		5 VAL A 200
VAL A 195
PHE A 162
SER A 192
GLY A  60
 None
 1.28A 4mm4B-1hkhA:
undetectable		 4mm4B-1hkhA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0n XANTHAN LYASE

(Bacillus sp.
GL1) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		5 VAL A 466
ALA A 467
TYR A 500
GLY A 469
THR A 464
 None
 1.15A 4mm4B-1j0nA:
0.0		 4mm4B-1j0nA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j1w ISOCITRATE
DEHYDROGENASE

(Azotobacter
vinelandii) 		PF03971
(IDH) 		5 VAL A 385
ALA A 383
TYR A 386
PHE A 554
THR A 525
 None
 1.18A 4mm4B-1j1wA:
0.0		 4mm4B-1j1wA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1c MAJOR COAT PROTEIN

(Saccharomyces
cerevisiae
virus L-A) 		PF09220
(LA-virus_coat) 		5 VAL A  32
TYR A  47
PHE A 474
SER A 469
THR A 591
 None
 1.26A 4mm4B-1m1cA:
0.0		 4mm4B-1m1cA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qy9 HYPOTHETICAL PROTEIN
YDDE

(Escherichia
coli) 		PF02567
(PhzC-PhzF) 		5 ASP A 113
VAL A  77
ALA A  78
TYR A  81
VAL A  82
 None
 1.10A 4mm4B-1qy9A:
undetectable		 4mm4B-1qy9A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhk HYPOTHETICAL PROTEIN
YQEU

(Bacillus
subtilis) 		PF04452
(Methyltrans_RNA) 		5 VAL A 172
ALA A 173
TYR A 174
GLY A 226
THR A 218
 None
 1.31A 4mm4B-1vhkA:
0.0		 4mm4B-1vhkA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vqz LIPOATE-PROTEIN
LIGASE, PUTATIVE

(Streptococcus
pneumoniae) 		PF03099
(BPL_LplA_LipB)
PF10437
(Lip_prot_lig_C) 		5 VAL A  75
ALA A  74
VAL A  43
SER A  70
GLY A  72
 None
None
None
EDO  A 409 ( 4.5A)
None
 1.13A 4mm4B-1vqzA:
0.0		 4mm4B-1vqzA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT

(Thermotoga
maritima) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC) 		5 ALA A 617
TYR A 614
VAL A 613
PHE A 247
GLY A 624
 None
 1.15A 4mm4B-1xjeA:
0.0		 4mm4B-1xjeA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y25 PROBABLE THIOL
PEROXIDASE

(Mycobacterium
tuberculosis) 		PF08534
(Redoxin) 		5 ASP A  56
VAL A  64
VAL A  59
SER A  54
THR A  98
 None
None
ACT  A1200 (-3.7A)
None
None
 0.95A 4mm4B-1y25A:
undetectable		 4mm4B-1y25A:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y2i HYPOTHETICAL PROTEIN
S0862

(Shigella
flexneri) 		PF01906
(YbjQ_1) 		5 ASP A  81
TYR A  84
PHE A  62
SER A  99
GLY A  23
 None
 1.20A 4mm4B-1y2iA:
undetectable		 4mm4B-1y2iA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zej 3-HYDROXYACYL-COA
DEHYDROGENASE

(Archaeoglobus
fulgidus) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 VAL A  69
ALA A  68
VAL A   5
GLY A   9
THR A  75
 None
 1.24A 4mm4B-1zejA:
undetectable		 4mm4B-1zejA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9v GMP SYNTHASE

(Thermoplasma
acidophilum) 		PF00117
(GATase) 		5 ASP A   8
VAL A  65
TYR A  68
SER A  49
GLY A  82
 None
 1.10A 4mm4B-2a9vA:
undetectable		 4mm4B-2a9vA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b0t NADP ISOCITRATE
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF03971
(IDH) 		5 VAL A 381
ALA A 379
TYR A 382
PHE A 550
THR A 521
 None
 1.27A 4mm4B-2b0tA:
undetectable		 4mm4B-2b0tA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gh4 PUTATIVE GLYCOSYL
HYDROLASE YTER

(Bacillus
subtilis) 		PF07470
(Glyco_hydro_88) 		5 ALA A 307
TYR A 308
PHE A 324
PHE A 357
THR A 316
 None
 1.25A 4mm4B-2gh4A:
undetectable		 4mm4B-2gh4A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iht CARBOXYETHYLARGININE
SYNTHASE

(Streptomyces
clavuligerus) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 ASP A 409
VAL A  62
ALA A  63
PHE A  58
THR A  94
 None
 1.12A 4mm4B-2ihtA:
undetectable		 4mm4B-2ihtA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ji9 OXALYL-COA
DECARBOXYLASE

(Oxalobacter
formigenes) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 VAL A 474
ALA A 448
VAL A 446
PHE A 455
GLY A 431
 None
 1.24A 4mm4B-2ji9A:
undetectable		 4mm4B-2ji9A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lfu GNA2132

(Neisseria
meningitidis) 		PF01298
(TbpB_B_D) 		5 ALA A 341
TYR A 319
VAL A 318
PHE A 420
GLY A 321
 None
 1.12A 4mm4B-2lfuA:
undetectable		 4mm4B-2lfuA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6p GLYCOSYL TRANSFERASE

(Streptomyces
fradiae) 		PF06722
(DUF1205) 		5 TYR A 226
VAL A 221
ALA A 222
PHE A  15
SER A 225
 None
None
None
None
GOL  A1005 ( 2.7A)
 1.16A 4mm4B-2p6pA:
undetectable		 4mm4B-2p6pA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qa2 POLYKETIDE OXYGENASE
CABE

(Streptomyces) 		PF01494
(FAD_binding_3) 		5 VAL A  94
ALA A  93
PHE A  54
PHE A  63
THR A  99
 None
 0.89A 4mm4B-2qa2A:
undetectable		 4mm4B-2qa2A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qul D-TAGATOSE
3-EPIMERASE

(Pseudomonas
cichorii) 		PF01261
(AP_endonuc_2) 		5 VAL A 255
PHE A   7
PHE A 248
GLY A 260
THR A   9
 None
 1.16A 4mm4B-2qulA:
undetectable		 4mm4B-2qulA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ux7 PSEUDOAZURIN

(Achromobacter
cycloclastes) 		PF00127
(Copper-bind) 		5 VAL A  25
ALA A  26
PHE A  33
PHE A  68
GLY A  28
 None
 1.22A 4mm4B-2ux7A:
undetectable		 4mm4B-2ux7A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] SMALL CHAIN

(Azospirillum
brasilense) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20) 		5 ASP G 356
VAL G 365
ALA G 392
VAL G 390
THR G 360
 None
 1.27A 4mm4B-2vdcG:
undetectable		 4mm4B-2vdcG:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE

(Methanocaldococcus
jannaschii) 		PF00814
(Peptidase_M22)
PF01163
(RIO1) 		5 TYR A 221
ALA A 227
TYR A 190
TYR A 226
SER A 222
 None
 1.29A 4mm4B-2vwbA:
undetectable		 4mm4B-2vwbA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wkp NPH1-1, RAS-RELATED
C3 BOTULINUM TOXIN
SUBSTRATE 1

(Avena sativa;
Homo sapiens) 		PF00071
(Ras)
PF13426
(PAS_9) 		5 ASP A 419
VAL A 550
PHE A 580
GLY A 597
THR A 601
 None
 1.23A 4mm4B-2wkpA:
undetectable		 4mm4B-2wkpA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x30 PHOSPHORIBOSYL
ISOMERASE A

(Streptomyces
coelicolor) 		PF00977
(His_biosynth) 		5 VAL A  18
ALA A  17
VAL A  10
PHE A  58
GLY A  15
 None
 1.21A 4mm4B-2x30A:
undetectable		 4mm4B-2x30A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yij PHOSPHOLIPASE
A1-IIGAMMA

(Arabidopsis
thaliana) 		PF01764
(Lipase_3) 		5 ASP A 279
VAL A 315
PHE A 177
SER A 280
THR A 247
 None
 1.28A 4mm4B-2yijA:
undetectable		 4mm4B-2yijA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8z LIPASE

(Pseudomonas sp.
MIS38) 		PF00353
(HemolysinCabind) 		5 ALA A 237
TYR A 236
SER A 204
GLY A 210
THR A 282
 None
 1.14A 4mm4B-2z8zA:
undetectable		 4mm4B-2z8zA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aje PUTATIVE
UNCHARACTERIZED
PROTEIN ST1526

(Sulfurisphaera
tokodaii) 		PF01300
(Sua5_yciO_yrdC)
PF03481
(SUA5) 		5 VAL A 294
ALA A 295
VAL A 180
PHE A 318
GLY A 324
 None
 1.18A 4mm4B-3ajeA:
undetectable		 4mm4B-3ajeA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE

(Trypanosoma
brucei) 		PF01048
(PNP_UDP_1) 		5 ASP A 216
VAL A 155
ALA A 154
TYR A 231
THR A 208
 None
 1.27A 4mm4B-3bjeA:
undetectable		 4mm4B-3bjeA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE

(Mycobacterium
tuberculosis) 		PF00795
(CN_hydrolase)
PF02540
(NAD_synthase) 		5 ASP A 158
ALA A 107
VAL A 173
PHE A 155
GLY A 117
 None
 1.23A 4mm4B-3dlaA:
undetectable		 4mm4B-3dlaA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3p PROTEIN KINASE,
PUTATIVE GLYCOGEN
SYNTHASE KINASE

(Leishmania
major) 		PF00069
(Pkinase) 		5 VAL A  99
ALA A  47
VAL A  34
PHE A  20
GLY A  37
 None
 1.29A 4mm4B-3e3pA:
undetectable		 4mm4B-3e3pA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e4d ESTERASE D

(Agrobacterium
fabrum) 		PF00756
(Esterase) 		5 VAL A  76
TYR A  33
VAL A  34
SER A  70
GLY A  73
 None
 1.18A 4mm4B-3e4dA:
undetectable		 4mm4B-3e4dA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gl1 HEAT SHOCK PROTEIN
SSB1

(Saccharomyces
cerevisiae) 		PF00012
(HSP70) 		5 ASP A 209
ALA A 182
VAL A 338
SER A 211
THR A 147
 None
 1.18A 4mm4B-3gl1A:
undetectable		 4mm4B-3gl1A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gqc DNA REPAIR PROTEIN
REV1

(Homo sapiens) 		PF00817
(IMS)
PF11799
(IMS_C) 		5 VAL A 446
VAL A 444
PHE A 428
SER A 430
GLY A 432
 None
None
DCP  A 101 (-3.8A)
None
None
 1.25A 4mm4B-3gqcA:
undetectable		 4mm4B-3gqcA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ift GLYCINE CLEAVAGE
SYSTEM H PROTEIN

(Mycobacterium
tuberculosis) 		PF01597
(GCV_H) 		5 ASP A 104
VAL A  52
ALA A  51
SER A  79
GLY A  49
 None
 1.27A 4mm4B-3iftA:
undetectable		 4mm4B-3iftA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 5

(Homo sapiens) 		PF00443
(UCH)
PF00627
(UBA)
PF02148
(zf-UBP) 		5 ASP A 262
ALA A 233
TYR A 237
VAL A 234
THR A 213
 None
 1.27A 4mm4B-3ihpA:
undetectable		 4mm4B-3ihpA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3klb PUTATIVE
FLAVOPROTEIN

(Bacteroides
fragilis) 		PF12682
(Flavodoxin_4) 		5 VAL A   8
ALA A   9
PHE A 156
GLY A  84
THR A  28
 None
 1.20A 4mm4B-3klbA:
undetectable		 4mm4B-3klbA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kvn ESTERASE ESTA

(Pseudomonas
aeruginosa) 		no annotation 5 VAL X  90
ALA X  89
TYR X  93
PHE X  21
GLY X  19
 None
None
None
C8E  X 624 ( 4.0A)
None
 1.28A 4mm4B-3kvnX:
undetectable		 4mm4B-3kvnX:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l77 SHORT-CHAIN ALCOHOL
DEHYDROGENASE

(Thermococcus
sibiricus) 		PF00106
(adh_short) 		5 VAL A  83
ALA A 132
VAL A 134
PHE A  69
PHE A 121
 None
 1.07A 4mm4B-3l77A:
undetectable		 4mm4B-3l77A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldo 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo sapiens) 		PF00012
(HSP70) 		5 ASP A 231
ALA A 206
VAL A 360
SER A 233
THR A 171
 None
 1.13A 4mm4B-3ldoA:
undetectable		 4mm4B-3ldoA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ljp CHOLINE OXIDASE

(Arthrobacter
globiformis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 VAL A 502
ALA A 500
VAL A 515
SER A 268
GLY A 270
 None
FDA  A 547 (-3.3A)
FDA  A 547 (-4.7A)
None
FDA  A 547 (-3.6A)
 1.30A 4mm4B-3ljpA:
undetectable		 4mm4B-3ljpA:
21.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mpn TRANSPORTER

(Aquifex
aeolicus) 		PF00209
(SNF) 		7 VAL A 104
ALA A 105
TYR A 107
TYR A 108
VAL A 109
PHE A 259
SER A 355
 None
None
None
LEU  A 601 (-4.5A)
None
LEU  A 601 (-3.6A)
NA  A 751 ( 2.3A)
 0.39A 4mm4B-3mpnA:
59.2		 4mm4B-3mpnA:
97.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3a PROTEIN NRDI

(Escherichia
coli) 		PF07972
(Flavodoxin_NdrI) 		5 ALA C  57
VAL C  58
PHE C  86
SER C  81
GLY C  91
 None
None
FMN  C 134 (-3.6A)
FMN  C 134 ( 4.2A)
FMN  C 134 (-3.9A)
 1.07A 4mm4B-3n3aC:
undetectable		 4mm4B-3n3aC:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE

(Escherichia
coli) 		PF02784
(Orn_Arg_deC_N) 		5 TYR A 116
ALA A 291
TYR A 294
VAL A 295
GLY A 344
 None
 1.18A 4mm4B-3nzqA:
undetectable		 4mm4B-3nzqA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oc6 6-PHOSPHOGLUCONOLACT
ONASE

(Mycolicibacterium
smegmatis) 		PF01182
(Glucosamine_iso) 		5 VAL A 169
ALA A 121
TYR A 124
PHE A 132
GLY A 123
 None
 1.30A 4mm4B-3oc6A:
undetectable		 4mm4B-3oc6A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oep PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0988

(Thermus
thermophilus) 		PF02626
(CT_A_B)
PF02682
(CT_C_D) 		5 ALA A 335
TYR A 333
PHE A 298
PHE A 293
SER A 257
 None
 1.21A 4mm4B-3oepA:
undetectable		 4mm4B-3oepA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE ALPHA-SUBUNIT
6-PHOSPHOFRUCTO-1-KI
NASE BETA-SUBUNIT

(Komagataella
pastoris) 		PF00365
(PFK) 		5 ALA B 473
VAL B 474
SER B 348
GLY B 344
THR A 390
 None
 1.29A 4mm4B-3opyB:
undetectable		 4mm4B-3opyB:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkw REPLICASE LARGE
SUBUNIT

(Tobacco mosaic
virus) 		PF01443
(Viral_helicase1) 		5 VAL A1036
ALA A1034
SER A1030
GLY A1032
THR A1019
 None
 1.15A 4mm4B-3vkwA:
undetectable		 4mm4B-3vkwA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wyd LC-EST1C

(uncultured
organism) 		PF00326
(Peptidase_S9) 		5 VAL A 355
TYR A 308
VAL A 309
PHE A 491
GLY A 352
 None
 1.20A 4mm4B-3wydA:
undetectable		 4mm4B-3wydA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zl8 UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D-ALANINE LIGASE

(Thermotoga
maritima) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 ASP A 203
ALA A 267
PHE A 218
GLY A 220
THR A 216
 None
 1.29A 4mm4B-3zl8A:
undetectable		 4mm4B-3zl8A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  90
ALA A  89
TYR A  88
SER A 126
THR A  54
 None
9ZP  A1333 (-3.5A)
None
None
None
 1.31A 4mm4B-4b6lA:
undetectable		 4mm4B-4b6lA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cu8 GLYCOSIDE HYDROLASE
2

(Streptococcus
pneumoniae) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		5 VAL A 950
ALA A 951
TYR A 890
TYR A 888
GLY A 920
 None
None
EDO  A2026 ( 4.1A)
None
None
 1.05A 4mm4B-4cu8A:
undetectable		 4mm4B-4cu8A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dkn AMPHIOXUS GREEN
FLUORESCENT PROTEIN,
GFPA1

(Branchiostoma
floridae) 		PF01353
(GFP) 		5 ASP A 153
ALA A  85
TYR A  84
TYR A 175
SER A 173
 None
 1.29A 4mm4B-4dknA:
undetectable		 4mm4B-4dknA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h7u PYRANOSE
DEHYDROGENASE

(Leucoagaricus
meleagris) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 VAL A  29
ALA A  26
TYR A 562
VAL A 561
GLY A  24
 None
FED  A 801 (-3.5A)
None
FED  A 801 (-4.6A)
FED  A 801 (-3.3A)
 1.22A 4mm4B-4h7uA:
undetectable		 4mm4B-4h7uA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hkm ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Xanthomonas
campestris) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		5 ASP A 309
ALA A 301
VAL A 304
SER A 310
GLY A 299
 None
 1.29A 4mm4B-4hkmA:
undetectable		 4mm4B-4hkmA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hr6 LECTIN

(Trichosanthes
anguina) 		PF00161
(RIP)
PF00652
(Ricin_B_lectin) 		5 VAL C  89
VAL C  91
PHE C  48
SER B 232
GLY B 212
 None
 0.99A 4mm4B-4hr6C:
undetectable		 4mm4B-4hr6C:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwi HEAT SHOCK COGNATE
71 KDA PROTEIN

(Homo sapiens) 		PF00012
(HSP70) 		5 ASP A 206
ALA A 180
VAL A 335
SER A 208
THR A 145
 None
 1.16A 4mm4B-4hwiA:
undetectable		 4mm4B-4hwiA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m98 PILIN GLYCOSYLATION
PROTEIN

(Neisseria
gonorrhoeae) 		PF00132
(Hexapep) 		5 ASP A 232
VAL A 265
ALA A 264
VAL A 204
GLY A 208
 None
 1.05A 4mm4B-4m98A:
undetectable		 4mm4B-4m98A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5p UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF09994
(DUF2235) 		5 ASP A 102
ALA A 154
TYR A 157
SER A 106
GLY A 108
 None
 1.27A 4mm4B-4o5pA:
undetectable		 4mm4B-4o5pA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9r SMOOTHENED
HOMOLOG/SOLUBLE
CYTOCHROME B562
CHIMERIC PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF01534
(Frizzled)
PF07361
(Cytochrom_B562) 		5 TYR A 394
ASP A 473
VAL A 404
PHE A 391
GLY A 393
 CY8  A1201 (-4.3A)
CY8  A1201 (-4.2A)
None
None
None
 1.17A 4mm4B-4o9rA:
undetectable		 4mm4B-4o9rA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psp ALPHA-FUCOSIDASE
GH29

(Fusarium
graminearum) 		PF01120
(Alpha_L_fucos)
PF16757
(Fucosidase_C) 		5 ASP A 303
VAL A 167
ALA A 120
TYR A  32
GLY A  30
 GOL  A 622 (-2.6A)
None
None
None
None
 1.09A 4mm4B-4pspA:
undetectable		 4mm4B-4pspA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r2f EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1

(Pseudarthrobacter
chlorophenolicus) 		PF01547
(SBP_bac_1) 		5 VAL A 166
ALA A 165
TYR A 163
VAL A 164
PHE A 149
 None
 1.27A 4mm4B-4r2fA:
undetectable		 4mm4B-4r2fA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rtf CHAPERONE PROTEIN
DNAK

(Mycobacterium
tuberculosis) 		PF00012
(HSP70) 		5 ASP D 177
ALA D 152
VAL D 311
SER D 179
THR D 117
 ATP  D 601 ( 4.5A)
None
None
None
None
 1.06A 4mm4B-4rtfD:
undetectable		 4mm4B-4rtfD:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u28 PHOSPHORIBOSYL
ISOMERASE A

(Streptomyces
sviceus) 		PF00977
(His_biosynth) 		5 VAL A  22
ALA A  21
VAL A  14
PHE A  62
GLY A  19
 None
 1.12A 4mm4B-4u28A:
undetectable		 4mm4B-4u28A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wed ABC TRANSPORTER,
PERIPLASMIC
SOLUTE-BINDING
PROTEIN

(Sinorhizobium
meliloti) 		PF00496
(SBP_bac_5) 		5 ASP A 269
ALA A 499
VAL A 266
SER A 496
GLY A 244
 None
 1.26A 4mm4B-4wedA:
undetectable		 4mm4B-4wedA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x2r 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE

(Actinomyces
urogenitalis) 		PF00977
(His_biosynth) 		5 VAL A  16
ALA A  15
VAL A   8
PHE A  56
GLY A  13
 None
 1.11A 4mm4B-4x2rA:
undetectable		 4mm4B-4x2rA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9s PHOSPHORIBOSYL
ISOMERASE A

(Streptomyces
sp. Mg1) 		PF00977
(His_biosynth) 		5 VAL A  20
ALA A  19
VAL A  12
PHE A  60
GLY A  17
 None
 1.08A 4mm4B-4x9sA:
undetectable		 4mm4B-4x9sA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xa8 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
NAD-BINDING

(Xanthobacter
autotrophicus) 		PF02826
(2-Hacid_dh_C) 		5 ALA A 233
VAL A 203
PHE A 260
GLY A 235
THR A 280
 None
 1.17A 4mm4B-4xa8A:
undetectable		 4mm4B-4xa8A:
22.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster) 		PF00209
(SNF) 		6 ASP A  46
VAL A 120
TYR A 123
TYR A 124
SER A 421
GLY A 425
 41U  A 605 ( 3.3A)
41U  A 605 (-4.2A)
None
41U  A 605 ( 3.8A)
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
 0.32A 4mm4B-4xnuA:
40.3		 4mm4B-4xnuA:
30.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xpr ALPHA-GLUCOSIDASE

(Pseudopedobacter
saltans) 		PF01055
(Glyco_hydro_31)
PF17137
(DUF5110) 		5 VAL A 203
TYR A 144
VAL A 139
PHE A  71
GLY A 205
 None
 1.20A 4mm4B-4xprA:
undetectable		 4mm4B-4xprA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5axh DEXTRANASE

(Thermoanaerobacter
pseudethanolicus) 		PF13199
(Glyco_hydro_66) 		5 VAL A 127
ALA A 126
TYR A  79
TYR A 125
VAL A 124
 None
 1.28A 4mm4B-5axhA:
undetectable		 4mm4B-5axhA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cc2 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		5 ASP A  38
VAL A   7
TYR A  48
SER A  41
THR A   9
 None
None
CL  A 305 (-4.0A)
None
None
 1.17A 4mm4B-5cc2A:
undetectable		 4mm4B-5cc2A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ce6 FACT-SPT16

(Cicer arietinum) 		PF00557
(Peptidase_M24)
PF14826
(FACT-Spt16_Nlob) 		5 VAL A  55
ALA A  54
VAL A  87
PHE A 194
GLY A 157
 None
 1.27A 4mm4B-5ce6A:
undetectable		 4mm4B-5ce6A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epg ALDEHYDE OXIDASE

(Homo sapiens) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 ASP A1093
VAL A1163
TYR A1161
SER A1265
GLY A1192
 None
 1.01A 4mm4B-5epgA:
undetectable		 4mm4B-5epgA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f56 SINGLE-STRANDED-DNA-
SPECIFIC EXONUCLEASE

(Deinococcus
radiodurans) 		PF01368
(DHH)
PF02272
(DHHA1) 		5 VAL A 681
ALA A 679
TYR A 682
VAL A 689
PHE A 624
 None
 1.16A 4mm4B-5f56A:
undetectable		 4mm4B-5f56A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fpn HEAT SHOCK-RELATED
70 KDA PROTEIN 2

(Homo sapiens) 		PF00012
(HSP70) 		5 ASP A 208
ALA A 180
VAL A 337
SER A 210
THR A 145
 None
 1.16A 4mm4B-5fpnA:
undetectable		 4mm4B-5fpnA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g10 HDAH

(Pseudomonas
aeruginosa) 		PF00850
(Hist_deacetyl) 		5 ASP A 338
VAL A 273
TYR A 317
VAL A 318
SER A 283
 None
 1.28A 4mm4B-5g10A:
undetectable		 4mm4B-5g10A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hcc COMPLEMENT C5

(Homo sapiens) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF07677
(A2M_recep)
PF07678
(A2M_comp) 		5 VAL A1423
ALA A1422
TYR A1496
TYR A1498
SER A1007
 None
 1.20A 4mm4B-5hccA:
undetectable		 4mm4B-5hccA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hp6 EXTRACELLULAR
ARABINANASE

(Geobacillus
stearothermophilus) 		PF04616
(Glyco_hydro_43)
PF13385
(Laminin_G_3)
PF16369
(GH43_C) 		5 ASP A 473
ALA A 328
VAL A 391
SER A 471
GLY A 330
 None
 1.31A 4mm4B-5hp6A:
undetectable		 4mm4B-5hp6A:
21.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i6z SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER

(Homo sapiens) 		PF00209
(SNF) 		8 TYR A  95
ASP A  98
ALA A 173
TYR A 175
TYR A 176
SER A 438
GLY A 442
THR A 497
 None
 0.81A 4mm4B-5i6zA:
41.9		 4mm4B-5i6zA:
32.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jmv PROBABLE
BIFUNCTIONAL TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN

(Methanocaldococcus
jannaschii) 		PF00814
(Peptidase_M22) 		5 TYR A 221
ALA A 227
TYR A 190
TYR A 226
SER A 222
 None
 1.25A 4mm4B-5jmvA:
undetectable		 4mm4B-5jmvA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jrl DIPEPTIDYL
AMINOPEPTIDASES/ACYL
AMINOACYL-PEPTIDASES
-LIKE PROTEIN

(Sphingopyxis
alaskensis) 		PF00326
(Peptidase_S9) 		5 ASP A 691
VAL A 490
ALA A 456
TYR A 488
GLY A 554
 None
 1.28A 4mm4B-5jrlA:
undetectable		 4mm4B-5jrlA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kvu ISOCITRATE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF03971
(IDH) 		5 ASP A 647
ALA A 152
TYR A 156
VAL A 153
GLY A 641
 None
 1.30A 4mm4B-5kvuA:
undetectable		 4mm4B-5kvuA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l7v GLYCOSIDE HYDROLASE

(Bacteroides
vulgatus) 		PF13320
(DUF4091) 		5 TYR A 491
VAL A 130
ALA A 131
SER A 497
THR A 106
 None
 1.20A 4mm4B-5l7vA:
undetectable		 4mm4B-5l7vA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0s GLUCOSYLCERAMIDASE

(Thermoanaerobacterium
xylanolyticum) 		PF04685
(DUF608)
PF12215
(Glyco_hydr_116N)
PF17168
(DUF5127) 		5 ALA A 615
TYR A 543
PHE A 556
GLY A 619
THR A 560
 None
 1.24A 4mm4B-5o0sA:
undetectable		 4mm4B-5o0sA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o1r GNA2132

(Neisseria
meningitidis) 		no annotation 5 ALA A 341
TYR A 319
VAL A 318
PHE A 420
GLY A 321
 None
 1.22A 4mm4B-5o1rA:
undetectable		 4mm4B-5o1rA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5c PUTATIVE
DECARBOXYLASE
INVOLVED IN
DESFERRIOXAMINE
BIOSYNTHESIS

(Erwinia
amylovora) 		no annotation 6 VAL A 466
ALA A 465
TYR A 104
PHE A 460
SER A  58
GLY A 463
 None
 1.28A 4mm4B-5o5cA:
undetectable		 4mm4B-5o5cA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oex -

(-) 		no annotation 5 ASP A 314
VAL A 311
PHE A 436
SER A 328
GLY A 333
 CU  A 601 (-2.1A)
None
None
None
None
 1.17A 4mm4B-5oexA:
undetectable		 4mm4B-5oexA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis) 		no annotation 5 TYR A 564
VAL A 754
ALA A 726
SER A 721
GLY A 703
 None
 1.26A 4mm4B-5ot1A:
undetectable		 4mm4B-5ot1A:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t0l BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Toxoplasma
gondii) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		5 ASP A 244
VAL A 317
VAL A 247
PHE A 325
SER A 233
 None
 1.22A 4mm4B-5t0lA:
undetectable		 4mm4B-5t0lA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tu4 PAGF
PRENYLTRANSFERASE

(Planktothrix
agardhii) 		no annotation 5 VAL A 168
ALA A 187
PHE A 107
SER A 226
GLY A 224
 None
 1.22A 4mm4B-5tu4A:
undetectable		 4mm4B-5tu4A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vaz DNA PRIMASE

(Pseudomonas
aeruginosa) 		PF08275
(Toprim_N)
PF10410
(DnaB_bind)
PF13662
(Toprim_4) 		5 ALA A 141
TYR A 144
VAL A 142
PHE A 209
GLY A 161
 None
SO4  A 501 (-4.9A)
None
None
None
 1.24A 4mm4B-5vazA:
undetectable		 4mm4B-5vazA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vis DIHYDROPTEROATE
SYNTHASE

(soil metagenome) 		PF00809
(Pterin_bind) 		5 VAL A 107
PHE A 183
SER A 211
GLY A 179
THR A  51
 None
 1.30A 4mm4B-5visA:
undetectable		 4mm4B-5visA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjj MULTI DRUG EFFLUX
TRANSPORTER

(Camelina sativa) 		PF01554
(MatE) 		5 ALA A 415
TYR A 411
TYR A 410
SER A 440
GLY A 435
 None
 1.30A 4mm4B-5xjjA:
undetectable		 4mm4B-5xjjA:
25.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byx SHORT ULVAN LYASE

(Alteromonas sp.
LOR) 		no annotation 5 TYR A 303
ALA A 267
TYR A 268
GLY A 301
THR A 242
 GOL  A 611 (-4.5A)
None
None
None
None
 1.26A 4mm4B-6byxA:
undetectable		 4mm4B-6byxA:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d47 BETA SLIDING CLAMP

(Mycobacterium
marinum) 		no annotation 5 VAL A 123
ALA A 122
TYR A 126
VAL A  41
THR A  78
 None
 1.30A 4mm4B-6d47A:
undetectable		 4mm4B-6d47A:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dxt -

(-) 		no annotation 5 ASP A 262
ALA A 233
TYR A 237
VAL A 234
THR A 213
 None
HHY  A 701 ( 3.7A)
None
HHY  A 701 ( 4.5A)
None
 1.29A 4mm4B-6dxtA:
undetectable		 4mm4B-6dxtA:
undetectable