SIMILAR PATTERNS OF AMINO ACIDS FOR 4MM4_A_8PRA603_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5l UREASE (ALPHA
SUBUNIT)

(Klebsiella
aerogenes) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		5 VAL C 421
ALA C 418
PHE C 491
GLY C 416
ASP C 431
 None
 1.18A 4mm4A-1a5lC:
undetectable		 4mm4A-1a5lC:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1buc BUTYRYL-COA
DEHYDROGENASE

(Megasphaera
elsdenii) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 VAL A  28
ALA A  25
GLY A  20
ASP A  32
THR A 210
 None
 1.28A 4mm4A-1bucA:
0.7		 4mm4A-1bucA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cvm PHYTASE

(Bacillus
amyloliquefaciens) 		PF02333
(Phytase) 		5 ASP A 217
ALA A 267
TYR A 266
GLY A 270
ASP A 373
 None
 1.26A 4mm4A-1cvmA:
undetectable		 4mm4A-1cvmA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dts DETHIOBIOTIN
SYNTHETASE

(Escherichia
coli) 		PF13500
(AAA_26) 		5 VAL A  39
ALA A  40
PHE A 128
PHE A 130
SER A  81
 None
 1.34A 4mm4A-1dtsA:
undetectable		 4mm4A-1dtsA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE

(Streptomyces
clavuligerus) 		PF00491
(Arginase) 		5 VAL A 280
ALA A  49
GLY A 118
ASP A 285
THR A 290
 None
 1.26A 4mm4A-1gq7A:
0.0		 4mm4A-1gq7A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz7 LIPASE 2

(Diutina rugosa) 		PF00135
(COesterase) 		5 ASP A 392
PHE A 517
GLY A 446
ASP A 412
THR A 416
 None
 1.18A 4mm4A-1gz7A:
0.0		 4mm4A-1gz7A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ist CYCLOPHILIN A

(Saccharomyces
cerevisiae) 		PF00160
(Pro_isomerase) 		5 ALA A  47
TYR A  46
GLY A  40
ASP A  64
THR A  66
 None
 1.22A 4mm4A-1istA:
undetectable		 4mm4A-1istA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0n XANTHAN LYASE

(Bacillus sp.
GL1) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		5 VAL A 466
ALA A 467
TYR A 500
GLY A 469
THR A 464
 None
 1.13A 4mm4A-1j0nA:
0.1		 4mm4A-1j0nA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j1w ISOCITRATE
DEHYDROGENASE

(Azotobacter
vinelandii) 		PF03971
(IDH) 		5 VAL A 385
ALA A 383
TYR A 386
PHE A 554
THR A 525
 None
 1.21A 4mm4A-1j1wA:
0.0		 4mm4A-1j1wA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1c MAJOR COAT PROTEIN

(Saccharomyces
cerevisiae
virus L-A) 		PF09220
(LA-virus_coat) 		5 VAL A  32
TYR A  47
PHE A 474
SER A 469
THR A 591
 None
 1.26A 4mm4A-1m1cA:
0.0		 4mm4A-1m1cA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1od6 PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Thermus
thermophilus) 		PF01467
(CTP_transf_like) 		5 VAL A  32
ALA A  33
TYR A   5
GLY A   7
THR A  59
 None
None
None
PNS  A1161 (-3.6A)
None
 1.26A 4mm4A-1od6A:
undetectable		 4mm4A-1od6A:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6u TRYPTOPHANYL-TRNA
SYNTHETASE

(Homo sapiens) 		PF00579
(tRNA-synt_1b) 		5 TYR A 100
VAL A  90
PHE A 339
GLY A  97
ASP A  86
 None
 1.33A 4mm4A-1r6uA:
undetectable		 4mm4A-1r6uA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ru4 PECTATE LYASE

(Dickeya
chrysanthemi) 		PF13229
(Beta_helix) 		5 VAL A 118
ALA A 117
GLY A 146
ASP A 120
THR A 150
 None
 1.38A 4mm4A-1ru4A:
undetectable		 4mm4A-1ru4A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s4f RNA-DEPENDENT RNA
POLYMERASE

(Pestivirus A) 		PF00998
(RdRP_3) 		5 TYR A 591
PHE A 547
SER A 554
ASP A 593
THR A 668
 None
 1.26A 4mm4A-1s4fA:
undetectable		 4mm4A-1s4fA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tyg THIAZOLE
BIOSYNTHESIS PROTEIN
THIG

(Bacillus
subtilis) 		PF05690
(ThiG) 		5 VAL A 132
ALA A 133
PHE A 142
PHE A 157
THR A 119
 None
 1.34A 4mm4A-1tygA:
undetectable		 4mm4A-1tygA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhk HYPOTHETICAL PROTEIN
YQEU

(Bacillus
subtilis) 		PF04452
(Methyltrans_RNA) 		5 VAL A 172
ALA A 173
TYR A 174
GLY A 226
THR A 218
 None
 1.33A 4mm4A-1vhkA:
undetectable		 4mm4A-1vhkA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8o BACTERIAL SIALIDASE

(Micromonospora
viridifaciens) 		PF00754
(F5_F8_type_C)
PF10633
(NPCBM_assoc)
PF13088
(BNR_2) 		5 TYR A 296
ASP A 291
ALA A 250
SER A 295
ASP A 242
 None
GOL  A1652 (-4.9A)
None
None
None
 1.29A 4mm4A-1w8oA:
undetectable		 4mm4A-1w8oA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y2i HYPOTHETICAL PROTEIN
S0862

(Shigella
flexneri) 		PF01906
(YbjQ_1) 		5 ASP A  81
TYR A  84
PHE A  62
SER A  99
GLY A  23
 None
 1.20A 4mm4A-1y2iA:
undetectable		 4mm4A-1y2iA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yyr TRICHODIENE SYNTHASE

(Fusarium
sporotrichioides) 		PF06330
(TRI5) 		5 ALA A 332
PHE A   9
PHE A 325
SER A 308
THR A  13
 None
 1.37A 4mm4A-1yyrA:
undetectable		 4mm4A-1yyrA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9v GMP SYNTHASE

(Thermoplasma
acidophilum) 		PF00117
(GATase) 		5 ASP A   8
VAL A  65
TYR A  68
SER A  49
GLY A  82
 None
 1.09A 4mm4A-2a9vA:
undetectable		 4mm4A-2a9vA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfe ALLERGEN

(Malassezia
sympodialis) 		PF00160
(Pro_isomerase) 		5 ALA A  47
TYR A  46
GLY A  40
ASP A  64
THR A  66
 None
 1.26A 4mm4A-2cfeA:
undetectable		 4mm4A-2cfeA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gh4 PUTATIVE GLYCOSYL
HYDROLASE YTER

(Bacillus
subtilis) 		PF07470
(Glyco_hydro_88) 		5 ALA A 307
TYR A 308
PHE A 324
PHE A 357
THR A 316
 None
 1.33A 4mm4A-2gh4A:
undetectable		 4mm4A-2gh4A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2huf ALANINE GLYOXYLATE
AMINOTRANSFERASE

(Aedes aegypti) 		PF00266
(Aminotran_5) 		5 ASP A 240
VAL A 224
TYR A 227
PHE A  73
PHE A 251
 None
 1.28A 4mm4A-2hufA:
undetectable		 4mm4A-2hufA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iht CARBOXYETHYLARGININE
SYNTHASE

(Streptomyces
clavuligerus) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		6 ASP A 409
VAL A  62
ALA A  63
PHE A  58
ASP A  98
THR A  94
 None
 1.18A 4mm4A-2ihtA:
undetectable		 4mm4A-2ihtA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6p GLYCOSYL TRANSFERASE

(Streptomyces
fradiae) 		PF06722
(DUF1205) 		5 TYR A 226
VAL A 221
ALA A 222
PHE A  15
SER A 225
 None
None
None
None
GOL  A1005 ( 2.7A)
 1.18A 4mm4A-2p6pA:
undetectable		 4mm4A-2p6pA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qul D-TAGATOSE
3-EPIMERASE

(Pseudomonas
cichorii) 		PF01261
(AP_endonuc_2) 		5 VAL A 255
PHE A   7
PHE A 248
GLY A 260
THR A   9
 None
 1.17A 4mm4A-2qulA:
undetectable		 4mm4A-2qulA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Escherichia
coli) 		PF01266
(DAO)
PF16901
(DAO_C) 		5 ALA A 418
TYR A 421
TYR A 417
PHE A 446
THR A 471
 None
None
None
None
EDO  A1957 ( 4.4A)
 1.07A 4mm4A-2r4jA:
undetectable		 4mm4A-2r4jA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ux7 PSEUDOAZURIN

(Achromobacter
cycloclastes) 		PF00127
(Copper-bind) 		5 VAL A  25
ALA A  26
PHE A  33
PHE A  68
GLY A  28
 None
 1.25A 4mm4A-2ux7A:
undetectable		 4mm4A-2ux7A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wkp NPH1-1, RAS-RELATED
C3 BOTULINUM TOXIN
SUBSTRATE 1

(Avena sativa;
Homo sapiens) 		PF00071
(Ras)
PF13426
(PAS_9) 		5 ASP A 419
VAL A 550
PHE A 580
GLY A 597
THR A 601
 None
 1.19A 4mm4A-2wkpA:
undetectable		 4mm4A-2wkpA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yij PHOSPHOLIPASE
A1-IIGAMMA

(Arabidopsis
thaliana) 		PF01764
(Lipase_3) 		5 ASP A 279
VAL A 315
PHE A 177
SER A 280
THR A 247
 None
 1.25A 4mm4A-2yijA:
undetectable		 4mm4A-2yijA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ypf AVRBS3

(Xanthomonas
campestris) 		PF03377
(TAL_effector) 		5 VAL A 275
ALA A 274
SER A 299
GLY A 303
THR A 283
 None
 1.32A 4mm4A-2ypfA:
undetectable		 4mm4A-2ypfA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8z LIPASE

(Pseudomonas sp.
MIS38) 		PF00353
(HemolysinCabind) 		5 ALA A 237
TYR A 236
SER A 204
GLY A 210
THR A 282
 None
 1.17A 4mm4A-2z8zA:
undetectable		 4mm4A-2z8zA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8o LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WZZE

(Escherichia
coli) 		no annotation 5 VAL A 180
ALA A 181
TYR A 179
PHE A 105
THR A  62
 None
 1.34A 4mm4A-3b8oA:
undetectable		 4mm4A-3b8oA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE

(Trypanosoma
brucei) 		PF01048
(PNP_UDP_1) 		5 ASP A 216
VAL A 155
ALA A 154
TYR A 231
THR A 208
 None
 1.33A 4mm4A-3bjeA:
undetectable		 4mm4A-3bjeA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c7m THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBA-LIKE

(Escherichia
coli) 		PF01323
(DSBA) 		5 ALA A  28
TYR A 101
PHE A  93
GLY A  65
ASP A  36
 None
None
CL  A 206 (-4.6A)
None
CL  A 206 ( 4.4A)
 1.10A 4mm4A-3c7mA:
undetectable		 4mm4A-3c7mA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e82 PUTATIVE
OXIDOREDUCTASE

(Klebsiella
pneumoniae) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 ASP A 264
PHE A 163
PHE A 249
SER A 139
GLY A 143
 None
 1.36A 4mm4A-3e82A:
undetectable		 4mm4A-3e82A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edy TRIPEPTIDYL-PEPTIDAS
E 1

(Homo sapiens) 		PF09286
(Pro-kuma_activ) 		5 ALA A 363
SER A 381
GLY A 411
ASP A 360
THR A 474
 None
 1.34A 4mm4A-3edyA:
undetectable		 4mm4A-3edyA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fys PROTEIN DEGV

(Bacillus
subtilis) 		PF02645
(DegV) 		5 ASP A 218
VAL A 254
TYR A 251
SER A 222
GLY A 224
 None
 1.35A 4mm4A-3fysA:
undetectable		 4mm4A-3fysA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbx GLUTAMATE
DECARBOXYLASE 1

(Arabidopsis
thaliana) 		PF00282
(Pyridoxal_deC) 		5 TYR A 278
SER A 247
GLY A 275
ASP A 424
THR A  66
 LLP  A 277 ( 4.7A)
LLP  A 277 ( 4.6A)
LLP  A 277 ( 4.2A)
None
None
 1.36A 4mm4A-3hbxA:
undetectable		 4mm4A-3hbxA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k40 AROMATIC-L-AMINO-ACI
D DECARBOXYLASE

(Drosophila
melanogaster) 		PF00282
(Pyridoxal_deC) 		5 VAL A 239
ALA A 238
GLY A 185
ASP A 270
THR A 152
 None
None
None
LLP  A 302 ( 2.7A)
None
 1.14A 4mm4A-3k40A:
undetectable		 4mm4A-3k40A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k40 AROMATIC-L-AMINO-ACI
D DECARBOXYLASE

(Drosophila
melanogaster) 		PF00282
(Pyridoxal_deC) 		5 VAL A 239
ALA A 238
SER A 208
ASP A 270
THR A 152
 None
None
None
LLP  A 302 ( 2.7A)
None
 1.30A 4mm4A-3k40A:
undetectable		 4mm4A-3k40A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3klb PUTATIVE
FLAVOPROTEIN

(Bacteroides
fragilis) 		PF12682
(Flavodoxin_4) 		5 VAL A   8
ALA A   9
PHE A 156
GLY A  84
THR A  28
 None
 1.13A 4mm4A-3klbA:
undetectable		 4mm4A-3klbA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kvn ESTERASE ESTA

(Pseudomonas
aeruginosa) 		no annotation 5 VAL X  90
ALA X  89
TYR X  93
PHE X  21
GLY X  19
 None
None
None
C8E  X 624 ( 4.0A)
None
 1.30A 4mm4A-3kvnX:
undetectable		 4mm4A-3kvnX:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1r FORMIMIDOYLGLUTAMASE

(Bacillus
subtilis) 		PF00491
(Arginase) 		5 VAL A 288
ALA A  54
GLY A 124
ASP A 293
THR A 298
 None
 1.37A 4mm4A-3m1rA:
undetectable		 4mm4A-3m1rA:
19.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mpn TRANSPORTER

(Aquifex
aeolicus) 		PF00209
(SNF) 		7 VAL A 104
ALA A 105
TYR A 107
TYR A 108
PHE A 259
SER A 355
ASP A 404
 None
None
None
LEU  A 601 (-4.5A)
LEU  A 601 (-3.6A)
NA  A 751 ( 2.3A)
None
 0.40A 4mm4A-3mpnA:
59.1		 4mm4A-3mpnA:
97.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ob8 BETA-GALACTOSIDASE

(Kluyveromyces
lactis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N) 		5 ASP A 906
ALA A 555
SER A 562
GLY A 553
THR A 793
 None
 1.30A 4mm4A-3ob8A:
undetectable		 4mm4A-3ob8A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oc6 6-PHOSPHOGLUCONOLACT
ONASE

(Mycolicibacterium
smegmatis) 		PF01182
(Glucosamine_iso) 		5 VAL A 169
ALA A 121
TYR A 124
PHE A 132
GLY A 123
 None
 1.28A 4mm4A-3oc6A:
undetectable		 4mm4A-3oc6A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oep PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0988

(Thermus
thermophilus) 		PF02626
(CT_A_B)
PF02682
(CT_C_D) 		5 ALA A 335
TYR A 333
PHE A 298
PHE A 293
SER A 257
 None
 1.22A 4mm4A-3oepA:
undetectable		 4mm4A-3oepA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pym GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
3

(Saccharomyces
cerevisiae) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 VAL A 260
ALA A 263
PHE A 293
SER A 291
GLY A 273
 None
 1.38A 4mm4A-3pymA:
undetectable		 4mm4A-3pymA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3scy HYPOTHETICAL
BACTERIAL
6-PHOSPHOGLUCONOLACT
ONASE

(Bacteroides
fragilis) 		PF10282
(Lactonase) 		5 VAL A 307
ALA A 308
TYR A 297
GLY A 323
THR A 327
 None
 1.30A 4mm4A-3scyA:
undetectable		 4mm4A-3scyA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tl6 PURINE NUCLEOSIDE
PHOSPHORYLASE

(Entamoeba
histolytica) 		PF01048
(PNP_UDP_1) 		5 ALA A  78
TYR A  77
SER A  73
GLY A  75
THR A   7
 None
 1.34A 4mm4A-3tl6A:
undetectable		 4mm4A-3tl6A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkw REPLICASE LARGE
SUBUNIT

(Tobacco mosaic
virus) 		PF01443
(Viral_helicase1) 		5 VAL A1036
ALA A1034
SER A1030
GLY A1032
THR A1019
 None
 1.14A 4mm4A-3vkwA:
undetectable		 4mm4A-3vkwA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zl8 UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D-ALANINE LIGASE

(Thermotoga
maritima) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 ASP A 203
ALA A 267
PHE A 218
GLY A 220
THR A 216
 None
 1.31A 4mm4A-3zl8A:
undetectable		 4mm4A-3zl8A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aip FE-REGULATED PROTEIN
B

(Neisseria
meningitidis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 ALA A 448
SER A 155
GLY A 460
ASP A 451
THR A 456
 None
 1.35A 4mm4A-4aipA:
undetectable		 4mm4A-4aipA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  90
ALA A  89
TYR A  88
SER A 126
THR A  54
 None
9ZP  A1333 (-3.5A)
None
None
None
 1.33A 4mm4A-4b6lA:
undetectable		 4mm4A-4b6lA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bs9 TRUD

(uncultured
Prochloron sp.
06037A) 		PF02624
(YcaO) 		5 ASP A 442
PHE A 439
GLY A 331
ASP A 499
THR A 516
 None
 1.19A 4mm4A-4bs9A:
undetectable		 4mm4A-4bs9A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cpd ALCOHOL
DEHYDROGENASE

(Thermus sp.
ATN1) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 VAL A 266
ALA A 265
PHE A  85
GLY A 245
THR A 156
 NAD  A1407 (-4.0A)
None
NAD  A1407 ( 4.9A)
NAD  A1407 ( 4.8A)
NAD  A1407 (-3.3A)
 1.28A 4mm4A-4cpdA:
undetectable		 4mm4A-4cpdA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cu8 GLYCOSIDE HYDROLASE
2

(Streptococcus
pneumoniae) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		5 VAL A 950
ALA A 951
TYR A 890
TYR A 888
GLY A 920
 None
None
EDO  A2026 ( 4.1A)
None
None
 1.04A 4mm4A-4cu8A:
undetectable		 4mm4A-4cu8A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dkn AMPHIOXUS GREEN
FLUORESCENT PROTEIN,
GFPA1

(Branchiostoma
floridae) 		PF01353
(GFP) 		5 ASP A 153
ALA A  85
TYR A  84
TYR A 175
SER A 173
 None
 1.30A 4mm4A-4dknA:
undetectable		 4mm4A-4dknA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ged ASCORBATE PEROXIDASE

(Leishmania
major) 		PF00141
(peroxidase) 		5 VAL A 125
ALA A 127
TYR A 129
SER A 119
THR A 288
 None
 1.38A 4mm4A-4gedA:
undetectable		 4mm4A-4gedA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9t DESIGNED UNNATURAL
AMINO ACID DEPENDENT
METALLOPROTEIN

(Micromonospora
viridifaciens) 		PF13088
(BNR_2) 		5 TYR A 296
ASP A 291
ALA A 250
SER A 295
ASP A 242
 None
GOL  A 501 (-4.7A)
None
None
None
 1.35A 4mm4A-4j9tA:
undetectable		 4mm4A-4j9tA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mee DIFFUSE ADHERENCE
ADHESIN

(Escherichia
coli) 		PF03797
(Autotransporter) 		5 ASP A 984
VAL A1162
ALA A1161
GLY A1133
THR A1129
 None
 1.28A 4mm4A-4meeA:
undetectable		 4mm4A-4meeA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o59 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Bos taurus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 VAL O 259
ALA O 262
PHE O 292
SER O 290
GLY O 272
 None
 1.35A 4mm4A-4o59O:
undetectable		 4mm4A-4o59O:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9r SMOOTHENED
HOMOLOG/SOLUBLE
CYTOCHROME B562
CHIMERIC PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF01534
(Frizzled)
PF07361
(Cytochrom_B562) 		5 TYR A 394
ASP A 473
VAL A 404
PHE A 391
GLY A 393
 CY8  A1201 (-4.3A)
CY8  A1201 (-4.2A)
None
None
None
 1.17A 4mm4A-4o9rA:
undetectable		 4mm4A-4o9rA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psp ALPHA-FUCOSIDASE
GH29

(Fusarium
graminearum) 		PF01120
(Alpha_L_fucos)
PF16757
(Fucosidase_C) 		5 ASP A 303
VAL A 167
ALA A 120
TYR A  32
GLY A  30
 GOL  A 622 (-2.6A)
None
None
None
None
 1.10A 4mm4A-4pspA:
undetectable		 4mm4A-4pspA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvc DEXTRANSUCRASE

(Leuconostoc
mesenteroides) 		PF02324
(Glyco_hydro_70) 		5 VAL A1902
TYR A1893
SER A1896
GLY A1899
THR A1977
 None
 1.20A 4mm4A-4tvcA:
undetectable		 4mm4A-4tvcA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wl1 LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WZZE

(Escherichia
coli) 		PF02706
(Wzz) 		5 VAL A 180
ALA A 181
TYR A 179
PHE A 105
THR A  62
 None
 1.37A 4mm4A-4wl1A:
undetectable		 4mm4A-4wl1A:
23.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster) 		PF00209
(SNF) 		7 ASP A  46
VAL A 120
TYR A 123
TYR A 124
SER A 421
GLY A 425
ASP A 475
 41U  A 605 ( 3.3A)
41U  A 605 (-4.2A)
None
41U  A 605 ( 3.8A)
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
None
 0.73A 4mm4A-4xnuA:
40.2		 4mm4A-4xnuA:
30.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zv9 UNCHARACTERIZED
PROTEIN

(Escherichia
coli) 		PF01738
(DLH) 		5 VAL A 121
ALA A 122
PHE A 290
GLY A 125
THR A 183
 None
 1.30A 4mm4A-4zv9A:
undetectable		 4mm4A-4zv9A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c00 MDBA PROTEIN

(Corynebacterium
diphtheriae) 		PF13462
(Thioredoxin_4) 		5 VAL A 143
ALA A 142
GLY A 137
ASP A 148
THR A 151
 None
 1.37A 4mm4A-5c00A:
undetectable		 4mm4A-5c00A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c54 DIHYDRODIPICOLINATE
SYNTHASE/N-ACETYLNEU
RAMINATE LYASE

(Corynebacterium
glutamicum) 		PF00701
(DHDPS) 		5 VAL A 105
ALA A 106
TYR A 138
SER A  48
THR A  78
 None
 1.35A 4mm4A-5c54A:
undetectable		 4mm4A-5c54A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cc2 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		5 ASP A  38
VAL A   7
TYR A  48
SER A  41
THR A   9
 None
None
CL  A 305 (-4.0A)
None
None
 1.17A 4mm4A-5cc2A:
undetectable		 4mm4A-5cc2A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5clw 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Homo sapiens) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		5 VAL A 145
TYR A 155
PHE A 110
SER A 148
GLY A  97
 None
 1.33A 4mm4A-5clwA:
undetectable		 4mm4A-5clwA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgk ACTIVE HELICASE

(Staphylococcus
aureus) 		PF06048
(DUF927) 		5 VAL A 261
SER A 225
GLY A 184
ASP A 263
THR A 308
 None
None
None
MG  A 702 ( 3.9A)
None
 1.37A 4mm4A-5dgkA:
undetectable		 4mm4A-5dgkA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dn6 ATP SYNTHASE SUBUNIT
ALPHA

(Paracoccus
denitrificans) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		5 VAL A 159
SER A 371
GLY A 349
ASP A 154
THR A 148
 None
 1.38A 4mm4A-5dn6A:
undetectable		 4mm4A-5dn6A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo sapiens) 		PF00012
(HSP70) 		5 ALA A 398
TYR A 396
PHE A  45
GLY A  43
THR A 411
 None
 1.36A 4mm4A-5e84A:
undetectable		 4mm4A-5e84A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epg ALDEHYDE OXIDASE

(Homo sapiens) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 ASP A1093
VAL A1163
TYR A1161
SER A1265
GLY A1192
 None
 1.04A 4mm4A-5epgA:
undetectable		 4mm4A-5epgA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fse UREASE SUBUNIT ALPHA

(Sporosarcina
pasteurii) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		5 VAL C 424
ALA C 421
PHE C 494
GLY C 419
ASP C 434
 None
 1.18A 4mm4A-5fseC:
undetectable		 4mm4A-5fseC:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hcc COMPLEMENT C5

(Homo sapiens) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF07677
(A2M_recep)
PF07678
(A2M_comp) 		5 VAL A1423
ALA A1422
TYR A1496
TYR A1498
SER A1007
 None
 1.22A 4mm4A-5hccA:
undetectable		 4mm4A-5hccA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5huo NICOTINATE-NUCLEOTID
E DIPHOSPHORYLASE
(CARBOXYLATING)

(Streptococcus
pyogenes) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		5 ASP A  82
ALA A 152
TYR A 151
ASP A   7
THR A  58
 None
 1.25A 4mm4A-5huoA:
undetectable		 4mm4A-5huoA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i33 ADENYLOSUCCINATE
SYNTHETASE

(Cryptococcus
neoformans) 		PF00709
(Adenylsucc_synt) 		5 TYR A 352
TYR A 376
PHE A 283
GLY A 351
THR A 275
 None
 1.34A 4mm4A-5i33A:
undetectable		 4mm4A-5i33A:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i6z SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER

(Homo sapiens) 		PF00209
(SNF) 		5 TYR A  95
ASP A  98
ALA A 169
SER A 438
GLY A 442
 None
 1.05A 4mm4A-5i6zA:
41.9		 4mm4A-5i6zA:
32.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i6z SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER

(Homo sapiens) 		PF00209
(SNF) 		8 TYR A  95
ASP A  98
ALA A 173
TYR A 175
TYR A 176
SER A 438
GLY A 442
THR A 497
 None
 0.84A 4mm4A-5i6zA:
41.9		 4mm4A-5i6zA:
32.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM

(Homo sapiens) 		PF00343
(Phosphorylase) 		5 VAL A 452
TYR A 374
PHE A 471
PHE A 479
GLY A 454
 None
 1.38A 4mm4A-5ikpA:
undetectable		 4mm4A-5ikpA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jia RAN-BINDING PROTEIN
10

(Mus musculus) 		PF00622
(SPRY) 		5 VAL A  46
ALA A  45
TYR A  43
GLY A 101
THR A  51
 None
 1.36A 4mm4A-5jiaA:
undetectable		 4mm4A-5jiaA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jmd HEPARINASE III
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07940
(Hepar_II_III)
PF16889
(Hepar_II_III_N) 		5 VAL A 535
ALA A 616
PHE A 515
GLY A 537
ASP A 533
 None
 1.31A 4mm4A-5jmdA:
undetectable		 4mm4A-5jmdA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jmv PROBABLE
BIFUNCTIONAL TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN

(Methanocaldococcus
jannaschii) 		PF00814
(Peptidase_M22) 		5 TYR A 221
ALA A 227
TYR A 190
TYR A 226
SER A 222
 None
 1.28A 4mm4A-5jmvA:
undetectable		 4mm4A-5jmvA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kh0 SMALL GTP-BINDING
PROTEIN

(Thermosipho
melanesiensis) 		PF01926
(MMR_HSR1) 		5 ASP A 176
ALA A 206
SER A 175
GLY A 210
THR A 260
 None
 1.32A 4mm4A-5kh0A:
undetectable		 4mm4A-5kh0A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzm TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Francisella
tularensis) 		PF00290
(Trp_syntA) 		5 VAL A 221
ALA A 224
PHE A 259
PHE A  20
GLY A 231
 None
 1.34A 4mm4A-5kzmA:
undetectable		 4mm4A-5kzmA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5c PUTATIVE
DECARBOXYLASE
INVOLVED IN
DESFERRIOXAMINE
BIOSYNTHESIS

(Erwinia
amylovora) 		no annotation 6 VAL A 466
ALA A 465
TYR A 104
PHE A 460
SER A  58
GLY A 463
 None
 1.27A 4mm4A-5o5cA:
undetectable		 4mm4A-5o5cA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ok8 LPP20 LIPOPROTEIN

(Helicobacter
pylori) 		no annotation 5 VAL A  55
ALA A  56
TYR A  58
TYR A  61
ASP A  46
 None
 1.35A 4mm4A-5ok8A:
undetectable		 4mm4A-5ok8A:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis) 		no annotation 5 TYR A 564
VAL A 754
ALA A 726
SER A 721
GLY A 703
 None
 1.26A 4mm4A-5ot1A:
undetectable		 4mm4A-5ot1A:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tu4 PAGF
PRENYLTRANSFERASE

(Planktothrix
agardhii) 		no annotation 5 VAL A 168
ALA A 187
PHE A 107
SER A 226
GLY A 224
 None
 1.24A 4mm4A-5tu4A:
undetectable		 4mm4A-5tu4A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ukw GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE

(Homo sapiens) 		PF00479
(G6PD_N)
PF02781
(G6PD_C) 		5 TYR A 482
ALA A 318
GLY A 485
ASP A 325
THR A 243
 None
 1.31A 4mm4A-5ukwA:
undetectable		 4mm4A-5ukwA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v12 HERCYNYLCYSTEINE
SULFOXIDE LYASE

(Neurospora
crassa) 		no annotation 5 VAL C 190
ALA C 189
TYR C 129
SER C 154
ASP C 221
 None
None
None
None
EXA  C 247 ( 3.0A)
 1.27A 4mm4A-5v12C:
undetectable		 4mm4A-5v12C:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vbn DNA POLYMERASE
EPSILON SUBUNIT 2

(Homo sapiens) 		PF04042
(DNA_pol_E_B)
PF12213
(Dpoe2NT) 		5 VAL A 183
ALA A 226
GLY A 228
ASP A 199
THR A 167
 None
 1.32A 4mm4A-5vbnA:
undetectable		 4mm4A-5vbnA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5weo GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF00822
(PMP22_Claudin)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 VAL A 530
ALA A 532
TYR A 533
SER A 537
GLY A 535
 None
 1.31A 4mm4A-5weoA:
undetectable		 4mm4A-5weoA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjj MULTI DRUG EFFLUX
TRANSPORTER

(Camelina sativa) 		PF01554
(MatE) 		5 ALA A 415
TYR A 411
TYR A 410
SER A 440
GLY A 435
 None
 1.28A 4mm4A-5xjjA:
undetectable		 4mm4A-5xjjA:
25.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xw3 O-ACETYLSERINE LYASE

(Bacillus
anthracis) 		PF00291
(PALP) 		5 ASP A 292
ALA A 177
PHE A 290
GLY A 180
THR A 288
 None
 1.31A 4mm4A-5xw3A:
undetectable		 4mm4A-5xw3A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byx SHORT ULVAN LYASE

(Alteromonas sp.
LOR) 		no annotation 5 TYR A 303
ALA A 267
TYR A 268
GLY A 301
THR A 242
 GOL  A 611 (-4.5A)
None
None
None
None
 1.25A 4mm4A-6byxA:
undetectable		 4mm4A-6byxA:
8.48