SIMILAR PATTERNS OF AMINO ACIDS FOR 4MKC_A_4MKA1503

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 267
GLY A 273
VAL A 275
ALA A 288
LYS A 290
GLY A 340
LEU A 389
 P16  A   2 ( 4.2A)
None
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
 0.87A 4mkcA-1opkA:
30.9		 4mkcA-1opkA:
28.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
VAL A 624
ALA A 642
LYS A 644
GLY A 697
ASP A 698
LEU A 818
 None
 0.55A 4mkcA-1rjbA:
29.5		 4mkcA-1rjbA:
36.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 595
VAL A 603
ALA A 621
LYS A 623
GLY A 676
ASP A 677
LEU A 799
 STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 ( 3.8A)
None
STI  A   3 (-4.4A)
 0.54A 4mkcA-1t46A:
25.6		 4mkcA-1t46A:
34.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  15
GLY A  18
VAL A  23
ALA A  36
LYS A  38
LEU A  84
GLY A  90
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 ( 3.7A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
HYM  A 400 (-4.2A)
None
HYM  A 400 (-4.5A)
 0.80A 4mkcA-1zltA:
21.6		 4mkcA-1zltA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  15
VAL A  23
ALA A  36
LYS A  38
LEU A  84
GLY A  90
LEU A 137
ASP A 148
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
HYM  A 400 (-4.2A)
None
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
 0.67A 4mkcA-1zltA:
21.6		 4mkcA-1zltA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  19
VAL A  27
ALA A  40
LYS A  42
LEU A  93
LEU A  95
ASP A 161
 None
 0.57A 4mkcA-1zwsA:
23.7		 4mkcA-1zwsA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  19
VAL A  27
ALA A  40
LYS A  42
LEU A  93
LEU A  95
ASP A 161
 None
None
GOL  A3001 (-3.5A)
None
GOL  A3001 ( 4.5A)
None
None
 0.63A 4mkcA-2a2aA:
25.3		 4mkcA-2a2aA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buj SERINE/THREONINE-PRO
TEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  26
VAL A  34
ALA A  47
LEU A  98
GLY A 104
LEU A 155
ASP A 166
 STU  A1301 (-4.2A)
STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
STU  A1301 ( 4.7A)
STU  A1301 ( 4.0A)
STU  A1301 ( 4.8A)
None
 0.72A 4mkcA-2bujA:
23.9		 4mkcA-2bujA:
25.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU X  17
VAL X  25
ALA X  37
LYS X  39
GLY X  88
LEU X 137
ASP X 148
 STU  X 902 (-3.8A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 (-3.5A)
STU  X 902 (-4.4A)
STU  X 902 (-3.6A)
 0.68A 4mkcA-2dq7X:
31.8		 4mkcA-2dq7X:
35.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A 162
VAL A 170
ALA A 184
LYS A 186
LEU A 238
LEU A 290
ASP A 320
 None
 0.72A 4mkcA-2eu9A:
22.6		 4mkcA-2eu9A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		7 LEU A  19
GLY A  25
VAL A  27
ALA A  40
LYS A  42
LEU A  95
ASP A 155
 ADP  A 500 (-4.3A)
ADP  A 500 (-3.8A)
ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
ADP  A 500 (-2.9A)
ADP  A 500 ( 4.9A)
ADP  A 500 ( 2.9A)
 1.10A 4mkcA-2f9gA:
22.4		 4mkcA-2f9gA:
26.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		8 LEU A  19
VAL A  27
ALA A  40
LYS A  42
LEU A  95
ASP A  99
LEU A 144
ASP A 155
 ADP  A 500 (-4.3A)
ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
ADP  A 500 (-2.9A)
ADP  A 500 ( 4.9A)
ADP  A 500 (-3.5A)
ADP  A 500 (-4.3A)
ADP  A 500 ( 2.9A)
 0.76A 4mkcA-2f9gA:
22.4		 4mkcA-2f9gA:
26.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 273
VAL A 281
ALA A 293
LYS A 295
GLY A 344
LEU A 393
ASP A 404
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 (-4.2A)
 0.89A 4mkcA-2h8hA:
30.2		 4mkcA-2h8hA:
25.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 251
VAL A 259
ALA A 271
LYS A 273
GLY A 322
LEU A 371
ASP A 382
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 (-4.4A)
 0.64A 4mkcA-2hk5A:
24.3		 4mkcA-2hk5A:
33.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 248
GLY A 250
VAL A 256
ALA A 269
LYS A 271
GLY A 321
LEU A 370
ASP A 381
 GIN  A 600 ( 4.6A)
None
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
None
GIN  A 600 (-4.7A)
GIN  A 600 (-4.9A)
 0.97A 4mkcA-2hz0A:
31.2		 4mkcA-2hz0A:
33.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		6 VAL A 436
ALA A 452
LEU A 501
GLY A 505
LEU A 553
ASP A 564
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-4.3A)
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
4ST  A1687 (-4.7A)
 0.54A 4mkcA-2j0jA:
33.1		 4mkcA-2j0jA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		6 VAL A 436
ALA A 452
LYS A 454
LEU A 501
LEU A 553
ASP A 564
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 (-4.3A)
4ST  A1687 (-4.4A)
4ST  A1687 (-4.7A)
 0.59A 4mkcA-2j0jA:
33.1		 4mkcA-2j0jA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgz CELL DIVISION
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  13
VAL A  18
ALA A  31
LYS A  33
ASP A  86
LEU A 134
ASP A 145
 None
 0.97A 4mkcA-2jgzA:
24.3		 4mkcA-2jgzA:
22.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		7 GLY A 431
VAL A 436
ALA A 452
LYS A 454
LEU A 501
GLY A 505
LEU A 553
 BII  A1687 ( 4.1A)
BII  A1687 ( 4.7A)
BII  A1687 (-3.5A)
BII  A1687 (-2.9A)
BII  A1687 (-4.4A)
BII  A1687 (-3.6A)
BII  A1687 (-4.2A)
 0.51A 4mkcA-2jkmA:
32.5		 4mkcA-2jkmA:
36.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 588
VAL A 596
ALA A 614
LYS A 616
GLY A 669
ASP A 670
LEU A 785
 None
 0.52A 4mkcA-2ogvA:
30.6		 4mkcA-2ogvA:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 588
VAL A 596
ALA A 614
LYS A 616
GLY A 669
LEU A 785
ASP A 796
 None
 0.70A 4mkcA-2ogvA:
30.6		 4mkcA-2ogvA:
33.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		7 LEU A  25
VAL A  33
ALA A  46
LEU A 105
GLY A 109
LEU A 156
ASP A 167
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
None
ATP  A 381 ( 4.8A)
MN  A 382 (-2.0A)
 0.54A 4mkcA-2phkA:
23.1		 4mkcA-2phkA:
23.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qob EPHRIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 635
ALA A 651
LYS A 653
GLY A 705
SER A 709
LEU A 753
ASP A 764
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
None
 0.68A 4mkcA-2qobA:
34.2		 4mkcA-2qobA:
33.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 724
VAL A 732
ALA A 749
LYS A 751
LEU A 798
GLY A 802
LEU A 850
 GW7  A   1 ( 4.2A)
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 (-4.5A)
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
 0.68A 4mkcA-2r4bA:
30.5		 4mkcA-2r4bA:
32.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  19
VAL A  27
ALA A  40
LYS A  42
LEU A  93
LEU A  95
ASP A 161
 ADP  A1303 ( 3.9A)
ADP  A1303 (-4.0A)
ADP  A1303 (-3.5A)
ADP  A1303 (-2.7A)
ADP  A1303 ( 4.1A)
None
MG  A1304 ( 2.8A)
 0.61A 4mkcA-2w4kA:
25.1		 4mkcA-2w4kA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  19
VAL A  27
LYS A  42
LEU A  93
LEU A  95
GLY A  99
ASP A 161
 ADP  A1303 ( 3.9A)
ADP  A1303 (-4.0A)
ADP  A1303 (-2.7A)
ADP  A1303 ( 4.1A)
None
None
MG  A1304 ( 2.8A)
 0.87A 4mkcA-2w4kA:
25.1		 4mkcA-2w4kA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xk9 CHECKPOINT KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A 226
VAL A 234
ALA A 247
LYS A 249
LEU A 303
GLY A 307
LEU A 354
 XK9  A1511 (-3.8A)
XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
XK9  A1511 (-4.2A)
XK9  A1511 (-4.1A)
XK9  A1511 ( 3.7A)
XK9  A1511 (-4.6A)
 1.13A 4mkcA-2xk9A:
21.4		 4mkcA-2xk9A:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		7 LEU A  19
VAL A  27
ALA A  40
LYS A  42
LEU A  93
LEU A  95
ASP A 161
 AMP  A1302 (-3.7A)
AMP  A1302 (-4.2A)
AMP  A1302 (-3.6A)
AMP  A1302 (-2.8A)
AMP  A1302 ( 3.6A)
AMP  A1302 ( 4.9A)
AMP  A1302 (-3.1A)
 0.64A 4mkcA-2yabA:
25.4		 4mkcA-2yabA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		7 LEU A  19
VAL A  27
LYS A  42
LEU A  93
LEU A  95
GLY A  99
ASP A 161
 AMP  A1302 (-3.7A)
AMP  A1302 (-4.2A)
AMP  A1302 (-2.8A)
AMP  A1302 ( 3.6A)
AMP  A1302 ( 4.9A)
None
AMP  A1302 (-3.1A)
 0.85A 4mkcA-2yabA:
25.4		 4mkcA-2yabA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		10 LEU A  68
GLY A  71
VAL A  76
ALA A  92
LYS A  94
LEU A 141
GLY A 147
ASP A 148
LEU A 194
ASP A 205
 STU  A   1 (-3.8A)
STU  A   1 ( 4.1A)
None
STU  A   1 (-3.3A)
STU  A   1 (-2.8A)
STU  A   1 ( 4.6A)
STU  A   1 ( 3.9A)
STU  A   1 (-3.8A)
STU  A   1 (-4.6A)
STU  A   1 ( 3.8A)
 0.75A 4mkcA-2z7rA:
22.1		 4mkcA-2z7rA:
23.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A1002
GLY A1005
VAL A1010
ALA A1028
LYS A1030
LEU A1078
GLY A1082
ASP A1083
SER A1086
ASP A1150
 S91  A   1 ( 4.1A)
None
S91  A   1 ( 4.9A)
S91  A   1 (-3.2A)
S91  A   1 ( 4.2A)
S91  A   1 (-4.7A)
S91  A   1 (-3.3A)
S91  A   1 (-3.7A)
None
None
 0.76A 4mkcA-2z8cA:
30.8		 4mkcA-2z8cA:
37.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A1002
GLY A1008
VAL A1010
ALA A1028
LYS A1030
LEU A1078
ASP A1150
 S91  A   1 ( 4.1A)
None
S91  A   1 ( 4.9A)
S91  A   1 (-3.2A)
S91  A   1 ( 4.2A)
S91  A   1 (-4.7A)
None
 1.18A 4mkcA-2z8cA:
30.8		 4mkcA-2z8cA:
37.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 LEU A 253
VAL A 261
ALA A 273
LYS A 275
GLY A 325
LEU A 374
ASP A 385
 None
 0.65A 4mkcA-2zv7A:
32.3		 4mkcA-2zv7A:
34.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqr DEATH-ASSOCIATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  19
VAL A  27
ALA A  40
LYS A  42
LEU A  93
LEU A  95
ASP A 161
 4RB  A 401 ( 3.9A)
4RB  A 401 ( 4.4A)
4RB  A 401 (-3.3A)
4RB  A 401 ( 2.8A)
4RB  A 401 ( 4.1A)
4RB  A 401 (-4.4A)
GOL  A 503 ( 3.1A)
 0.50A 4mkcA-3bqrA:
21.7		 4mkcA-3bqrA:
23.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 484
GLY A 490
VAL A 492
ALA A 512
GLY A 567
LEU A 630
ASP A 641
 C4F  A   1 ( 3.9A)
None
None
C4F  A   1 (-3.3A)
None
C4F  A   1 (-4.6A)
C4F  A   1 (-4.5A)
 0.83A 4mkcA-3c4fA:
31.6		 4mkcA-3c4fA:
36.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  44
GLY A  50
VAL A  52
ALA A  65
LYS A  67
LEU A 120
ASP A 186
 985  A   1 (-4.1A)
None
985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 ( 2.8A)
985  A   1 (-4.3A)
985  A   1 ( 4.0A)
 1.07A 4mkcA-3f2aA:
17.3		 4mkcA-3f2aA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  44
VAL A  52
ALA A  65
LYS A  67
LEU A 120
ASP A 128
LEU A 174
ASP A 186
 985  A   1 (-4.1A)
985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 ( 2.8A)
985  A   1 (-4.3A)
985  A   1 (-4.7A)
985  A   1 (-4.8A)
985  A   1 ( 4.0A)
 0.86A 4mkcA-3f2aA:
17.3		 4mkcA-3f2aA:
24.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fzp PROTEIN TYROSINE
KINASE 2 BETA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 431
GLY A 434
VAL A 439
ALA A 455
LYS A 457
LEU A 504
GLY A 508
LEU A 556
 AGS  A 999 ( 4.4A)
AGS  A 999 (-3.0A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
AGS  A 999 (-2.5A)
AGS  A 999 (-4.4A)
None
AGS  A 999 (-4.5A)
 0.64A 4mkcA-3fzpA:
32.1		 4mkcA-3fzpA:
35.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 833
VAL A 841
ALA A 859
LYS A 861
GLY A 915
LEU A1029
ASP A1040
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
None
None
None
 0.77A 4mkcA-3hngA:
30.4		 4mkcA-3hngA:
30.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6u SERINE/THREONINE-PRO
TEIN KINASE CHK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00498
(FHA) 		8 LEU A 226
GLY A 229
VAL A 234
ALA A 247
LEU A 301
GLY A 307
LEU A 354
ASP A 368
 None
 0.96A 4mkcA-3i6uA:
22.0		 4mkcA-3i6uA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6u SERINE/THREONINE-PRO
TEIN KINASE CHK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00498
(FHA) 		8 LEU A 226
GLY A 229
VAL A 234
ALA A 247
LEU A 301
LEU A 303
GLY A 307
LEU A 354
 None
 0.84A 4mkcA-3i6uA:
22.0		 4mkcA-3i6uA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igo CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 GLY A  85
VAL A  90
LYS A 105
LEU A 154
GLY A 158
LEU A 205
ASP A 219
 ANP  A 610 (-2.9A)
ANP  A 610 (-3.9A)
ANP  A 610 (-2.8A)
GOL  A   1 (-4.6A)
None
None
ANP  A 610 ( 2.7A)
 1.01A 4mkcA-3igoA:
20.7		 4mkcA-3igoA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igo CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 LEU A  82
GLY A  85
VAL A  90
LYS A 105
LEU A 154
LEU A 205
ASP A 219
 ANP  A 610 ( 4.5A)
ANP  A 610 (-2.9A)
ANP  A 610 (-3.9A)
ANP  A 610 (-2.8A)
GOL  A   1 (-4.6A)
None
ANP  A 610 ( 2.7A)
 0.84A 4mkcA-3igoA:
20.7		 4mkcA-3igoA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igo CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 LEU A  82
VAL A  90
ALA A 103
LYS A 105
LEU A 154
LEU A 205
ASP A 219
 ANP  A 610 ( 4.5A)
ANP  A 610 (-3.9A)
ANP  A 610 ( 3.7A)
ANP  A 610 (-2.8A)
GOL  A   1 (-4.6A)
None
ANP  A 610 ( 2.7A)
 0.64A 4mkcA-3igoA:
20.7		 4mkcA-3igoA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		7 LEU A 680
GLY A 683
VAL A 689
LYS A 702
LEU A 745
LEU A 804
ASP A 828
 ADP  A2101 ( 4.1A)
ADP  A2101 (-3.3A)
ADP  A2101 (-4.5A)
ADP  A2101 (-2.7A)
ADP  A2101 ( 4.4A)
ADP  A2101 (-4.4A)
SR  A2103 (-2.6A)
 0.84A 4mkcA-3lj0A:
23.5		 4mkcA-3lj0A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		8 LEU A 680
VAL A 689
ALA A 700
LYS A 702
LEU A 745
LEU A 747
LEU A 804
ASP A 828
 ADP  A2101 ( 4.1A)
ADP  A2101 (-4.5A)
ADP  A2101 (-3.5A)
ADP  A2101 (-2.7A)
ADP  A2101 ( 4.4A)
None
ADP  A2101 (-4.4A)
SR  A2103 (-2.6A)
 0.60A 4mkcA-3lj0A:
23.5		 4mkcA-3lj0A:
21.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A1005
GLY A1008
VAL A1013
ALA A1031
LYS A1033
LEU A1081
GLY A1085
ASP A1086
SER A1089
 None
None
None
None
CCX  A   1 ( 3.7A)
None
None
None
None
 0.70A 4mkcA-3lw0A:
30.4		 4mkcA-3lw0A:
37.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi9 CELL DIVISION
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  33
ALA A  46
LYS A  48
ASP A 109
LEU A 156
ASP A 167
 None
 0.59A 4mkcA-3mi9A:
22.6		 4mkcA-3mi9A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  49
VAL A  57
ALA A  70
GLY A 126
SER A 130
LEU A 173
ASP A 184
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
XFE  A 351 (-4.6A)
None
 0.94A 4mkcA-3mvjA:
23.1		 4mkcA-3mvjA:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nie MAP2 KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		6 VAL A  44
ALA A  57
LYS A  59
LEU A 111
LEU A 163
ASP A 174
 ANP  A 430 (-4.2A)
ANP  A 430 (-3.5A)
ANP  A 430 (-2.5A)
ANP  A 430 ( 4.1A)
ANP  A 430 (-4.4A)
ANP  A 430 (-2.8A)
 0.55A 4mkcA-3nieA:
21.4		 4mkcA-3nieA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		9 LEU A  88
GLY A  91
VAL A  96
ALA A 109
LYS A 111
LEU A 159
GLY A 165
LEU A 212
ASP A 223
 JOZ  A 361 (-4.1A)
SO4  A   5 ( 4.4A)
JOZ  A 361 ( 4.7A)
JOZ  A 361 (-3.4A)
SO4  A   5 (-2.8A)
JOZ  A 361 (-4.0A)
None
None
SO4  A   5 ( 4.5A)
 0.77A 4mkcA-3nuuA:
24.2		 4mkcA-3nuuA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		11 LEU A 192
GLY A 195
VAL A 200
ALA A 213
LYS A 215
LEU A 263
LEU A 265
GLY A 269
ASP A 270
LEU A 318
ASP A 329
 AMP  A 577 ( 4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
AMP  A 577 ( 4.7A)
AMP  A 577 ( 4.9A)
None
AMP  A 577 (-3.6A)
AMP  A 577 (-4.8A)
AMP  A 577 (-4.0A)
 0.60A 4mkcA-3nyoA:
23.2		 4mkcA-3nyoA:
21.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 726
GLY A 729
VAL A 734
ALA A 751
LYS A 753
LEU A 800
GLY A 804
LEU A 852
 03Q  A   1 (-3.8A)
03Q  A   1 (-3.3A)
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.6A)
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
 0.74A 4mkcA-3pp0A:
31.8		 4mkcA-3pp0A:
31.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A 201
VAL A 206
ALA A 217
LYS A 219
GLY A 273
LEU A 329
ASP A 340
 None
TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
None
 0.80A 4mkcA-3q4tA:
25.3		 4mkcA-3q4tA:
28.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 LEU A  63
VAL A  71
ALA A  84
LYS A  86
GLY A 150
LEU A 197
ASP A 211
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
ANP  A1634 (-4.4A)
MG  A 529 (-2.2A)
 0.69A 4mkcA-3q5iA:
22.0		 4mkcA-3q5iA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 LEU A 361
VAL A 369
ALA A 382
GLY A 439
ASP A 440
LEU A 486
ASP A 497
 07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
None
07U  A   1 (-3.9A)
07U  A   1 (-4.3A)
07U  A   1 (-3.6A)
 0.84A 4mkcA-3txoA:
14.4		 4mkcA-3txoA:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 LEU A 361
VAL A 369
ALA A 382
LYS A 384
ASP A 440
LEU A 486
ASP A 497
 07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-3.0A)
07U  A   1 (-3.9A)
07U  A   1 (-4.3A)
07U  A   1 (-3.6A)
 0.81A 4mkcA-3txoA:
14.4		 4mkcA-3txoA:
26.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 544
VAL A 552
ALA A 570
GLY A 623
ASP A 624
LEU A 686
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-3.2A)
0F4  A 902 (-3.4A)
None
0F4  A 902 (-4.5A)
 0.42A 4mkcA-3v5qA:
30.5		 4mkcA-3v5qA:
37.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w18 AURORA KINASE A

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A 139
VAL A 147
ALA A 160
LYS A 162
LEU A 210
GLY A 216
LEU A 263
 N13  A 501 (-3.7A)
N13  A 501 ( 4.7A)
N13  A 501 ( 4.1A)
N13  A 501 (-2.9A)
N13  A 501 ( 4.8A)
N13  A 501 (-3.5A)
N13  A 501 (-4.5A)
 0.86A 4mkcA-3w18A:
21.9		 4mkcA-3w18A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  75
VAL A  83
ALA A  96
LYS A  98
GLY A 150
LEU A 198
 ANP  A 401 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
ANP  A 401 (-2.7A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
 0.59A 4mkcA-3wigA:
23.2		 4mkcA-3wigA:
22.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A1951
GLY A1957
VAL A1959
ALA A1978
LYS A1980
LEU A2026
LEU A2028
 VGH  A3000 ( 4.4A)
None
None
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
VGH  A3000 ( 4.2A)
VGH  A3000 ( 4.8A)
 1.22A 4mkcA-3zbfA:
34.0		 4mkcA-3zbfA:
45.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A1951
VAL A1959
ALA A1978
LYS A1980
LEU A2026
LEU A2028
GLY A2032
ASP A2033
LEU A2086
ASP A2102
 VGH  A3000 ( 4.4A)
None
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
VGH  A3000 ( 4.2A)
VGH  A3000 ( 4.8A)
VGH  A3000 (-3.5A)
VGH  A3000 (-4.5A)
VGH  A3000 (-4.3A)
None
 0.55A 4mkcA-3zbfA:
34.0		 4mkcA-3zbfA:
45.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 633
ALA A 649
LYS A 651
GLY A 703
SER A 707
LEU A 751
ASP A 762
 None
 0.54A 4mkcA-3zfxA:
34.1		 4mkcA-3zfxA:
31.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  59
GLY A  62
ALA A  80
LYS A  82
LEU A 130
LEU A 132
ASP A 194
 939  A1331 (-3.7A)
939  A1331 ( 3.7A)
939  A1331 (-3.5A)
939  A1331 (-2.6A)
939  A1331 ( 4.7A)
939  A1331 (-4.4A)
939  A1331 (-3.1A)
 0.61A 4mkcA-4a4lA:
24.8		 4mkcA-4a4lA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af3 AURORA KINASE B

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  83
GLY A  89
VAL A  91
ALA A 104
LYS A 106
LEU A 154
GLY A 160
 VX6  A 500 (-3.8A)
None
VX6  A 500 ( 4.8A)
VX6  A 500 (-3.4A)
VX6  A 500 (-3.3A)
None
VX6  A 500 (-3.3A)
 0.88A 4mkcA-4af3A:
19.7		 4mkcA-4af3A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af3 AURORA KINASE B

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  83
VAL A  91
ALA A 104
LYS A 106
LEU A 154
GLY A 160
LEU A 207
 VX6  A 500 (-3.8A)
VX6  A 500 ( 4.8A)
VX6  A 500 (-3.4A)
VX6  A 500 (-3.3A)
None
VX6  A 500 (-3.3A)
VX6  A 500 (-4.6A)
 0.75A 4mkcA-4af3A:
19.7		 4mkcA-4af3A:
23.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 840
VAL A 848
ALA A 866
LYS A 868
GLY A 922
LEU A1035
 B49  A2000 (-3.7A)
None
B49  A2000 (-3.5A)
B49  A2000 (-3.0A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
 0.58A 4mkcA-4agdA:
30.2		 4mkcA-4agdA:
35.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 560
GLY A 563
VAL A 568
ALA A 586
GLY A 639
ASP A 640
LEU A 699
 LTI  A1839 ( 4.2A)
None
None
LTI  A1839 (-3.3A)
LTI  A1839 (-3.4A)
None
LTI  A1839 (-4.2A)
 1.45A 4mkcA-4at3A:
30.9		 4mkcA-4at3A:
37.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 560
VAL A 568
ALA A 586
GLY A 639
ASP A 640
LEU A 699
ASP A 710
 LTI  A1839 ( 4.2A)
None
LTI  A1839 (-3.3A)
LTI  A1839 (-3.4A)
None
LTI  A1839 (-4.2A)
None
 0.57A 4mkcA-4at3A:
30.9		 4mkcA-4at3A:
37.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 VAL A  91
ALA A 104
LYS A 106
GLY A 160
ASP A 161
LEU A 208
ASP A 219
 None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
None
None
EDO  A1420 ( 4.8A)
None
 0.88A 4mkcA-4aw2A:
20.4		 4mkcA-4aw2A:
22.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 GLY A 100
VAL A 105
ALA A 121
LYS A 123
GLY A 175
SER A 179
LEU A 223
ASP A 234
 30K  A1365 ( 4.4A)
30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
30K  A1365 (-3.5A)
None
30K  A1365 (-4.5A)
30K  A1365 (-3.3A)
 0.50A 4mkcA-4aw5A:
27.5		 4mkcA-4aw5A:
32.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  68
ALA A  89
LYS A  91
LEU A 139
LEU A 141
ASP A 203
 9ZP  A1333 (-3.9A)
9ZP  A1333 (-3.5A)
None
9ZP  A1333 (-3.8A)
9ZP  A1333 (-4.7A)
None
 0.51A 4mkcA-4b6lA:
24.5		 4mkcA-4b6lA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		8 GLY A  64
VAL A  69
ALA A  82
LYS A  84
LEU A 137
LEU A 139
ASP A 143
LEU A 189
 None
R4L  A1394 (-4.0A)
R4L  A1394 ( 3.7A)
None
R4L  A1394 (-3.9A)
R4L  A1394 ( 4.9A)
R4L  A1394 ( 4.2A)
R4L  A1394 (-4.5A)
 0.73A 4mkcA-4b99A:
22.7		 4mkcA-4b99A:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		8 GLY A  64
VAL A  69
LYS A  84
LEU A 137
LEU A 139
ASP A 143
LEU A 189
ASP A 200
 None
R4L  A1394 (-4.0A)
None
R4L  A1394 (-3.9A)
R4L  A1394 ( 4.9A)
R4L  A1394 ( 4.2A)
R4L  A1394 (-4.5A)
None
 0.74A 4mkcA-4b99A:
22.7		 4mkcA-4b99A:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		8 LEU A 246
VAL A 254
ALA A 267
LYS A 269
LEU A 318
GLY A 324
LEU A 371
ASP A 382
 None
 0.87A 4mkcA-4c0tA:
22.8		 4mkcA-4c0tA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		7 LEU A  22
GLY A  25
VAL A  30
ALA A  43
GLY A  99
LEU A 146
ASP A 157
 STU  A1550 (-4.3A)
STU  A1550 (-3.8A)
None
STU  A1550 (-3.1A)
STU  A1550 (-3.4A)
STU  A1550 (-4.3A)
STU  A1550 (-3.6A)
 0.88A 4mkcA-4cfhA:
23.6		 4mkcA-4cfhA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		7 LEU A  22
GLY A  25
VAL A  30
ALA A  43
LYS A  45
GLY A  99
ASP A 157
 STU  A1550 (-4.3A)
STU  A1550 (-3.8A)
None
STU  A1550 (-3.1A)
STU  A1550 (-3.6A)
STU  A1550 (-3.4A)
STU  A1550 (-3.6A)
 0.89A 4mkcA-4cfhA:
23.6		 4mkcA-4cfhA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		8 LEU A 663
VAL A 671
ALA A 684
LYS A 686
GLY A 743
ASP A 744
LEU A 789
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
AGS  A1985 (-4.0A)
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 0.66A 4mkcA-4crsA:
22.2		 4mkcA-4crsA:
25.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		9 GLY A 570
VAL A 575
ALA A 588
LYS A 590
LEU A 638
GLY A 642
ASP A 643
LEU A 690
ASP A 701
 GUI  A 901 (-3.4A)
GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
GUI  A 901 (-2.8A)
GUI  A 901 (-4.4A)
GUI  A 901 (-3.5A)
GUI  A 901 ( 4.8A)
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
 0.46A 4mkcA-4e93A:
34.4		 4mkcA-4e93A:
36.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 515
VAL A 523
ALA A 541
GLY A 594
ASP A 595
LEU A 656
ASP A 667
 None
 0.74A 4mkcA-4f0iA:
30.6		 4mkcA-4f0iA:
35.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 377
VAL A 385
ALA A 400
LYS A 402
GLY A 454
LEU A 501
ASP A 512
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
0SB  A 701 (-3.9A)
 0.53A 4mkcA-4f4pA:
31.1		 4mkcA-4f4pA:
29.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 LEU A 514
VAL A 522
ALA A 538
LYS A 540
GLY A 599
ASP A 600
ASP A 663
 0T8  A 901 (-3.6A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
0T8  A 901 (-3.5A)
0T8  A 901 ( 3.8A)
0T8  A 901 (-3.9A)
0T8  A 901 (-4.5A)
 0.85A 4mkcA-4feqA:
11.0		 4mkcA-4feqA:
33.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 LEU A 514
VAL A 522
ALA A 538
LYS A 540
LEU A 593
GLY A 599
ASP A 663
 0T8  A 901 (-3.6A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
0T8  A 901 (-3.5A)
0T8  A 901 (-3.7A)
0T8  A 901 ( 3.8A)
0T8  A 901 (-4.5A)
 1.01A 4mkcA-4feqA:
11.0		 4mkcA-4feqA:
33.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  26
GLY A  29
VAL A  34
LYS A  49
LEU A  97
GLY A 101
LEU A 148
 ATP  A 401 (-3.8A)
ATP  A 401 (-3.2A)
ATP  A 401 (-4.1A)
ATP  A 401 (-3.0A)
ATP  A 401 ( 4.8A)
None
ATP  A 401 (-4.6A)
 0.95A 4mkcA-4fg8A:
23.1		 4mkcA-4fg8A:
23.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A1122
GLY A1125
VAL A1130
ALA A1148
LYS A1150
LEU A1196
LEU A1198
ASP A1203
LEU A1256
ASP A1270
 0UV  A1501 (-3.8A)
0UV  A1501 (-3.6A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 (-3.7A)
0UV  A1501 (-3.7A)
0UV  A1501 ( 4.8A)
0UV  A1501 ( 4.6A)
0UV  A1501 (-4.6A)
0UV  A1501 ( 4.2A)
 0.69A 4mkcA-4fodA:
47.6		 4mkcA-4fodA:
99.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A1122
VAL A1130
ALA A1148
LYS A1150
LEU A1196
GLY A1202
ASP A1203
SER A1206
LEU A1256
ASP A1270
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 (-3.7A)
0UV  A1501 (-3.7A)
0UV  A1501 (-3.6A)
0UV  A1501 ( 4.6A)
None
0UV  A1501 (-4.6A)
0UV  A1501 ( 4.2A)
 0.73A 4mkcA-4fodA:
47.6		 4mkcA-4fodA:
99.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A1122
VAL A1130
ALA A1148
LYS A1150
LEU A1196
LEU A1198
GLY A1202
ASP A1203
LEU A1256
ASP A1270
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 (-3.7A)
0UV  A1501 (-3.7A)
0UV  A1501 ( 4.8A)
0UV  A1501 (-3.6A)
0UV  A1501 ( 4.6A)
0UV  A1501 (-4.6A)
0UV  A1501 ( 4.2A)
 0.54A 4mkcA-4fodA:
47.6		 4mkcA-4fodA:
99.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  37
ALA A  50
LEU A 102
GLY A 106
ASP A 107
LEU A 153
ASP A 164
 STU  A 401 ( 4.9A)
STU  A 401 (-3.2A)
STU  A 401 (-4.4A)
STU  A 401 ( 3.7A)
STU  A 401 (-3.3A)
STU  A 401 (-4.7A)
STU  A 401 ( 3.9A)
 0.51A 4mkcA-4fr4A:
21.1		 4mkcA-4fr4A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3f NF-KAPPA-BETA-INDUCI
NG KINASE

(Mus musculus) 		PF00069
(Pkinase) 		6 GLY A 411
VAL A 416
ALA A 429
LEU A 473
GLY A 477
LEU A 524
 0WB  A 701 (-3.6A)
0WB  A 701 (-4.4A)
0WB  A 701 (-3.3A)
0WB  A 701 (-4.3A)
0WB  A 701 ( 4.5A)
0WB  A 701 (-4.3A)
 0.40A 4mkcA-4g3fA:
23.5		 4mkcA-4g3fA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 828
VAL A 836
ALA A 853
LYS A 855
GLY A 908
LEU A 956
ASP A 967
 19S  A1201 (-3.9A)
19S  A1201 (-4.4A)
19S  A1201 (-3.3A)
19S  A1201 (-3.5A)
19S  A1201 ( 3.8A)
19S  A1201 (-4.5A)
19S  A1201 ( 4.1A)
 0.79A 4mkcA-4hviA:
30.1		 4mkcA-4hviA:
27.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		9 LEU A 132
GLY A 135
VAL A 140
ALA A 156
LYS A 158
LEU A 207
GLY A 211
LEU A 259
ASP A 270
 None
 0.85A 4mkcA-4hzsA:
28.8		 4mkcA-4hzsA:
33.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 132
VAL A 140
ALA A 156
LYS A 158
LEU A 207
GLY A 211
LEU A 259
ASP A 270
 1G0  A 401 ( 4.5A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 ( 4.9A)
1G0  A 401 ( 4.5A)
1G0  A 401 (-4.6A)
None
 0.60A 4mkcA-4id7A:
31.4		 4mkcA-4id7A:
32.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A 406
GLY A 409
VAL A 414
ALA A 427
LYS A 429
LEU A 471
GLY A 475
LEU A 522
 T28  A 701 (-3.8A)
T28  A 701 ( 3.0A)
T28  A 701 (-4.7A)
T28  A 701 (-3.0A)
T28  A 701 ( 3.8A)
T28  A 701 ( 4.8A)
T28  A 701 ( 3.0A)
T28  A 701 (-3.9A)
 0.78A 4mkcA-4idtA:
23.6		 4mkcA-4idtA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrn RHOPTRY KINASE
FAMILY PROTEIN

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		7 LEU A 258
VAL A 266
ALA A 279
LYS A 281
ASP A 362
LEU A 416
ASP A 427
 ANP  A 601 ( 4.6A)
ANP  A 601 (-4.1A)
ANP  A 601 ( 3.9A)
ANP  A 601 (-3.2A)
ANP  A 601 (-4.1A)
ANP  A 601 ( 4.9A)
MG  A 603 ( 2.0A)
 0.62A 4mkcA-4jrnA:
20.3		 4mkcA-4jrnA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  18
VAL A  26
ALA A  39
LEU A  89
GLY A  95
LEU A 143
 631  A 301 (-3.4A)
631  A 301 (-4.6A)
631  A 301 (-3.3A)
631  A 301 ( 4.5A)
631  A 301 ( 3.7A)
631  A 301 (-4.0A)
 0.58A 4mkcA-4jxfA:
18.9		 4mkcA-4jxfA:
21.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 478
VAL A 486
ALA A 506
LYS A 508
GLY A 561
LEU A 624
ASP A 635
 ACP  A 801 (-3.8A)
ACP  A 801 (-4.2A)
ACP  A 801 (-3.3A)
ACP  A 801 (-2.7A)
ACP  A 801 ( 4.6A)
ACP  A 801 (-4.4A)
MG  A 802 ( 3.0A)
 0.69A 4mkcA-4k33A:
32.7		 4mkcA-4k33A:
36.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00169
(PH)
PF00615
(RGS) 		8 VAL A 205
ALA A 218
LYS A 220
LEU A 271
GLY A 277
ASP A 278
LEU A 324
ASP A 335
 29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-3.6A)
29X  A 702 ( 4.7A)
None
29X  A 702 ( 4.8A)
29X  A 702 (-4.6A)
29X  A 702 (-4.4A)
 1.01A 4mkcA-4mk0A:
13.8		 4mkcA-4mk0A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00169
(PH)
PF00615
(RGS) 		7 VAL A 205
ALA A 218
LYS A 220
LEU A 271
LEU A 273
GLY A 276
LEU A 324
 29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-3.6A)
29X  A 702 ( 4.7A)
29X  A 702 (-4.6A)
None
29X  A 702 (-4.6A)
 0.88A 4mkcA-4mk0A:
13.8		 4mkcA-4mk0A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00169
(PH)
PF00615
(RGS) 		7 VAL A 205
ALA A 218
LYS A 220
LEU A 271
LEU A 273
LEU A 324
ASP A 335
 29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-3.6A)
29X  A 702 ( 4.7A)
29X  A 702 (-4.6A)
29X  A 702 (-4.6A)
29X  A 702 (-4.4A)
 0.82A 4mkcA-4mk0A:
13.8		 4mkcA-4mk0A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		8 LEU A  78
GLY A  81
VAL A  86
ALA A  99
LEU A 148
GLY A 151
LEU A 199
ASP A 213
 STU  A 601 ( 4.0A)
STU  A 601 (-3.9A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-4.3A)
STU  A 601 (-3.4A)
STU  A 601 (-4.7A)
STU  A 601 (-4.3A)
 0.96A 4mkcA-4mvfA:
21.0		 4mkcA-4mvfA:
22.13