SIMILAR PATTERNS OF AMINO ACIDS FOR 4MK4_B_CHDB504_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
12as ASPARAGINE
SYNTHETASE

(Escherichia
coli) 		PF03590
(AsnA) 		3 LEU A 133
ILE A 291
ARG A 255
 None
None
ASN  A 331 (-3.2A)
 0.59A 4mk4B-12asA:
undetectable		 4mk4B-12asA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1crz TOLB PROTEIN

(Escherichia
coli) 		PF04052
(TolB_N)
PF07676
(PD40) 		3 LEU A  41
ILE A  16
ARG A  14
 None
 0.66A 4mk4B-1crzA:
undetectable		 4mk4B-1crzA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flc HAEMAGGLUTININ-ESTER
ASE-FUSION
GLYCOPROTEIN

(Influenza C
virus) 		PF08720
(Hema_stalk) 		3 LEU B 118
ILE B 122
ARG B 125
 None
 0.69A 4mk4B-1flcB:
undetectable		 4mk4B-1flcB:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyq CELL DIVISION
INHIBITOR (MIND-1)

(Archaeoglobus
fulgidus) 		PF01656
(CbiA) 		3 LEU A 115
ILE A   5
ARG A   3
 None
 0.67A 4mk4B-1hyqA:
3.4		 4mk4B-1hyqA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ig8 HEXOKINASE PII

(Saccharomyces
cerevisiae) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		3 LEU A 384
ILE A 388
ARG A 391
 None
 0.63A 4mk4B-1ig8A:
undetectable		 4mk4B-1ig8A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ii8 RAD50 ABC-ATPASE

(Pyrococcus
furiosus) 		PF13476
(AAA_23) 		3 LEU A 176
ILE A 180
ARG A 183
 None
 0.67A 4mk4B-1ii8A:
undetectable		 4mk4B-1ii8A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ion PROBABLE CELL
DIVISION INHIBITOR
MIND

(Pyrococcus
horikoshii) 		PF13614
(AAA_31) 		3 LEU A 116
ILE A   5
ARG A   3
 None
 0.70A 4mk4B-1ionA:
3.8		 4mk4B-1ionA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itz TRANSKETOLASE

(Zea mays) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		3 LEU A  82
ILE A  23
ARG A  24
 None
 0.69A 4mk4B-1itzA:
undetectable		 4mk4B-1itzA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ki9 ADENYLATE KINASE

(Methanothermococcus
thermolithotrophicus) 		PF13207
(AAA_17) 		3 LEU A  62
ILE A  70
ARG A  69
 None
 0.55A 4mk4B-1ki9A:
3.3		 4mk4B-1ki9A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kpl PUTATIVE CLC FAMILY,
CHLORINE TRANSPORT
PROTEIN

(Salmonella
enterica) 		PF00654
(Voltage_CLC) 		3 LEU A 444
ILE A 448
ARG A 451
 None
 0.51A 4mk4B-1kplA:
undetectable		 4mk4B-1kplA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus) 		PF01425
(Amidase) 		3 LEU A 224
ILE A 225
ARG A 285
 None
 0.65A 4mk4B-1mt5A:
undetectable		 4mk4B-1mt5A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nh3 DNA TOPOISOMERASE I

(Homo sapiens) 		PF01028
(Topoisom_I)
PF02919
(Topoisom_I_N)
PF14370
(Topo_C_assoc) 		3 LEU A 429
ILE A 435
ARG A 434
 None
 0.55A 4mk4B-1nh3A:
undetectable		 4mk4B-1nh3A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgd PROTEIN
(TRANSKETOLASE)

(Escherichia
coli) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		3 LEU A  70
ILE A  11
ARG A  12
 None
 0.57A 4mk4B-1qgdA:
3.7		 4mk4B-1qgdA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE

(Streptococcus
pneumoniae) 		PF00275
(EPSP_synthase) 		3 LEU A 147
ILE A  95
ARG A  96
 None
 0.63A 4mk4B-1rf5A:
undetectable		 4mk4B-1rf5A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6p PHENYLALANINE
AMMONIA-LYASE

(Rhodotorula
toruloides) 		PF00221
(Lyase_aromatic) 		3 LEU A 507
ILE A 508
ARG A 512
 None
 0.64A 4mk4B-1t6pA:
undetectable		 4mk4B-1t6pA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqi NUCLEOSIDE
DIPHOSPHATE KINASE

(Pyrobaculum
aerophilum) 		PF00334
(NDK) 		3 LEU A  31
ILE A  35
ARG A  38
 None
 0.64A 4mk4B-1xqiA:
undetectable		 4mk4B-1xqiA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y56 HYPOTHETICAL PROTEIN
PH1363

(Pyrococcus
horikoshii) 		PF07992
(Pyr_redox_2)
PF13510
(Fer2_4) 		3 LEU A 201
ILE A 102
ARG A 104
 None
 0.65A 4mk4B-1y56A:
undetectable		 4mk4B-1y56A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2y DNA/RNA-BINDING
PROTEIN ALBA 2

(Sulfolobus
solfataricus) 		PF01918
(Alba) 		3 LEU A  21
ILE A  24
ARG A  56
 None
 0.53A 4mk4B-2a2yA:
undetectable		 4mk4B-2a2yA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a3l AMP DEAMINASE

(Arabidopsis
thaliana) 		PF00962
(A_deaminase) 		3 LEU A 427
ILE A 420
ARG A 474
 None
 0.68A 4mk4B-2a3lA:
undetectable		 4mk4B-2a3lA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR

(Escherichia
coli) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02559
(CarD_CdnL_TRCF)
PF03461
(TRCF) 		3 LEU A  30
ILE A  34
ARG A  37
 None
 0.34A 4mk4B-2eyqA:
2.0		 4mk4B-2eyqA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f96 RIBONUCLEASE T

(Pseudomonas
aeruginosa) 		PF00929
(RNase_T) 		3 LEU A 205
ILE A 209
ARG A 212
 None
 0.66A 4mk4B-2f96A:
undetectable		 4mk4B-2f96A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fv8 RHO-RELATED
GTP-BINDING PROTEIN
RHOB

(Homo sapiens) 		PF00071
(Ras) 		3 LEU A 114
ILE A 151
ARG A 150
 None
 0.71A 4mk4B-2fv8A:
3.8		 4mk4B-2fv8A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gpe BIFUNCTIONAL PROTEIN
PUTA

(Escherichia
coli) 		no annotation 3 LEU A  32
ILE A  25
ARG A  24
 None
 0.57A 4mk4B-2gpeA:
undetectable		 4mk4B-2gpeA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h92 CYTIDYLATE KINASE

(Staphylococcus
aureus) 		PF02224
(Cytidylate_kin) 		3 LEU A 169
ILE A 173
ARG A 176
 None
None
C5P  A1300 (-3.1A)
 0.34A 4mk4B-2h92A:
3.0		 4mk4B-2h92A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ice COMPLEMENT C3 BETA
CHAIN

(Homo sapiens) 		PF01835
(A2M_N)
PF07703
(A2M_N_2) 		3 LEU A 297
ILE A 223
ARG A 282
 None
 0.70A 4mk4B-2iceA:
undetectable		 4mk4B-2iceA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3m PROLYL-TRNA
SYNTHETASE

(Enterococcus
faecalis) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF04073
(tRNA_edit) 		3 LEU A  21
ILE A  25
ARG A  28
 None
 0.68A 4mk4B-2j3mA:
undetectable		 4mk4B-2j3mA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ja1 THYMIDINE KINASE

(Bacillus cereus) 		PF00265
(TK) 		3 LEU A  25
ILE A  26
ARG A  30
 None
 0.63A 4mk4B-2ja1A:
2.8		 4mk4B-2ja1A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p5t PEZT

(Streptococcus
pneumoniae) 		PF06414
(Zeta_toxin) 		3 LEU B 250
ILE B 156
ARG B 157
 None
 0.61A 4mk4B-2p5tB:
2.9		 4mk4B-2p5tB:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pl1 TRANSCRIPTIONAL
REGULATORY PROTEIN
PHOP

(Escherichia
coli) 		PF00072
(Response_reg) 		3 LEU A  62
ILE A  63
ARG A  67
 None
 0.45A 4mk4B-2pl1A:
5.2		 4mk4B-2pl1A:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r51 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 26B

(Mus musculus) 		PF03643
(Vps26) 		3 LEU A 130
ILE A 147
ARG A  22
 None
 0.65A 4mk4B-2r51A:
undetectable		 4mk4B-2r51A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vfv XYLITOL OXIDASE

(Streptomyces
coelicolor) 		PF01565
(FAD_binding_4)
PF04030
(ALO) 		3 LEU A 107
ILE A 110
ARG A  86
 SFD  A1418 ( 4.3A)
SFD  A1418 (-4.1A)
None
 0.42A 4mk4B-2vfvA:
undetectable		 4mk4B-2vfvA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x5t ORF 131

(Sulfolobus
islandicus
rod-shaped
virus 1) 		no annotation 3 LEU A  73
ILE A  34
ARG A  33
 None
 0.63A 4mk4B-2x5tA:
undetectable		 4mk4B-2x5tA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yyv PROBABLE
2-PHOSPHOSULFOLACTAT
E PHOSPHATASE

(Thermotoga
maritima) 		PF04029
(2-ph_phosp) 		3 LEU A 148
ILE A 152
ARG A 155
 None
 0.71A 4mk4B-2yyvA:
undetectable		 4mk4B-2yyvA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbl PUTATIVE ISOMERASE

(Salmonella
enterica) 		PF07221
(GlcNAc_2-epim) 		3 LEU A 388
ILE A  20
ARG A  19
 None
 0.68A 4mk4B-2zblA:
undetectable		 4mk4B-2zblA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zm5 TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE

(Escherichia
coli) 		PF01715
(IPPT) 		3 LEU A 210
ILE A 214
ARG A 217
 None
 0.63A 4mk4B-2zm5A:
2.5		 4mk4B-2zm5A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahi XYLULOSE
5-PHOSPHATE/FRUCTOSE
6-PHOSPHATE
PHOSPHOKETOLASE

(Bifidobacterium
breve) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		3 LEU A 212
ILE A 295
ARG A 297
 None
 0.54A 4mk4B-3ahiA:
3.5		 4mk4B-3ahiA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai7 XYLULOSE-5-PHOSPHATE
/FRUCTOSE-6-PHOSPHAT
E PHOSPHOKETOLASE

(Bifidobacterium
longum) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		3 LEU A 212
ILE A 295
ARG A 297
 None
 0.52A 4mk4B-3ai7A:
3.6		 4mk4B-3ai7A:
17.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		3 LEU A 107
ILE A 111
ARG A 114
 CHD  A   3 ( 4.6A)
CHD  A   2 ( 4.7A)
CHD  A   2 (-3.6A)
 0.65A 4mk4B-3aqiA:
59.3		 4mk4B-3aqiA:
99.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b54 NUCLEOSIDE
DIPHOSPHATE KINASE

(Saccharomyces
cerevisiae) 		PF00334
(NDK) 		3 LEU A  21
ILE A  25
ARG A  28
 None
 0.67A 4mk4B-3b54A:
undetectable		 4mk4B-3b54A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		3 LEU A 725
ILE A 729
ARG A 732
 None
 0.72A 4mk4B-3bjcA:
undetectable		 4mk4B-3bjcA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bpk NITRILOTRIACETATE
MONOOXYGENASE
COMPONENT B

(Bacillus cereus) 		PF01613
(Flavin_Reduct) 		3 LEU A  56
ILE A 156
ARG A 139
 None
 0.68A 4mk4B-3bpkA:
undetectable		 4mk4B-3bpkA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ccg HD SUPERFAMILY
HYDROLASE

(Clostridium
acetobutylicum) 		PF01966
(HD) 		3 LEU A 173
ILE A 178
ARG A 181
 None
 0.63A 4mk4B-3ccgA:
undetectable		 4mk4B-3ccgA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e18 OXIDOREDUCTASE

(Listeria
innocua) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 LEU A 253
ILE A 248
ARG A 236
 None
 0.54A 4mk4B-3e18A:
3.1		 4mk4B-3e18A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eq2 PROBABLE
TWO-COMPONENT
RESPONSE REGULATOR

(Pseudomonas
aeruginosa) 		PF00072
(Response_reg)
PF07228
(SpoIIE) 		3 LEU A  67
ILE A  68
ARG A  72
 None
 0.67A 4mk4B-3eq2A:
4.5		 4mk4B-3eq2A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f8t PREDICTED ATPASE
INVOLVED IN
REPLICATION CONTROL,
CDC46/MCM FAMILY

(Methanopyrus
kandleri) 		PF00493
(MCM) 		3 LEU A 403
ILE A 407
ARG A 464
 None
 0.69A 4mk4B-3f8tA:
undetectable		 4mk4B-3f8tA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fvc GLYCOPROTEIN GP110

(Human
gammaherpesvirus
4) 		PF00606
(Glycoprotein_B)
PF17416
(Glycoprot_B_PH1)
PF17417
(Glycoprot_B_PH2) 		3 LEU A 107
ILE A 108
ARG A 201
 None
 0.69A 4mk4B-3fvcA:
undetectable		 4mk4B-3fvcA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3grc SENSOR PROTEIN,
KINASE

(Polaromonas sp.
JS666) 		PF00072
(Response_reg) 		3 LEU A 609
ILE A 610
ARG A 614
 None
 0.51A 4mk4B-3grcA:
4.0		 4mk4B-3grcA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdv RESPONSE REGULATOR

(Pseudomonas
putida) 		PF00072
(Response_reg) 		3 LEU A 131
ILE A 132
ARG A 136
 None
 0.61A 4mk4B-3hdvA:
3.9		 4mk4B-3hdvA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjh TRANSCRIPTION-REPAIR
-COUPLING FACTOR

(Escherichia
coli) 		no annotation 3 LEU A  30
ILE A  34
ARG A  37
 None
 0.65A 4mk4B-3hjhA:
2.4		 4mk4B-3hjhA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jd5 28S RIBOSOMAL
PROTEIN S35,
MITOCHONDRIAL

(Bos taurus) 		PF00411
(Ribosomal_S11) 		3 LEU k 207
ILE k 209
ARG k 199
 None
 0.63A 4mk4B-3jd5k:
undetectable		 4mk4B-3jd5k:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kom TRANSKETOLASE

(Francisella
tularensis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		3 LEU A  72
ILE A  13
ARG A  14
 None
 0.55A 4mk4B-3komA:
3.4		 4mk4B-3komA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m45 CELL ADHESION
MOLECULE 2

(Mus musculus) 		PF07686
(V-set) 		3 LEU A  81
ILE A  86
ARG A  85
 None
 0.55A 4mk4B-3m45A:
undetectable		 4mk4B-3m45A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nkh INTEGRASE

(Staphylococcus
aureus) 		PF00589
(Phage_integrase) 		3 LEU A  65
ILE A  96
ARG A  94
 None
 0.63A 4mk4B-3nkhA:
undetectable		 4mk4B-3nkhA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nmz APC VARIANT PROTEIN

(Homo sapiens) 		PF00514
(Arm) 		3 LEU A 387
ILE A 391
ARG A 348
 None
 0.63A 4mk4B-3nmzA:
undetectable		 4mk4B-3nmzA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3os4 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Yersinia pestis) 		PF04095
(NAPRTase) 		3 LEU A 335
ILE A 333
ARG A 332
 None
 0.63A 4mk4B-3os4A:
undetectable		 4mk4B-3os4A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvv CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA

(Mycobacterium
tuberculosis) 		PF08299
(Bac_DnaA_C) 		3 LEU A 497
ILE A 501
ARG A 504
 None
 0.70A 4mk4B-3pvvA:
undetectable		 4mk4B-3pvvA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pzl AGMATINE
UREOHYDROLASE

(Thermoplasma
volcanium) 		PF00491
(Arginase) 		3 LEU A 290
ILE A  61
ARG A  62
 None
 0.61A 4mk4B-3pzlA:
2.3		 4mk4B-3pzlA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qbd 3-DEHYDROQUINATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF01761
(DHQ_synthase) 		3 LEU A 251
ILE A 255
ARG A 258
 None
 0.71A 4mk4B-3qbdA:
2.8		 4mk4B-3qbdA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		3 LEU A 166
ILE A 170
ARG A 173
 None
 0.66A 4mk4B-3ry9A:
undetectable		 4mk4B-3ry9A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Coxiella
burnetii) 		PF00275
(EPSP_synthase) 		3 LEU A 148
ILE A  98
ARG A  99
 None
 0.64A 4mk4B-3tr1A:
undetectable		 4mk4B-3tr1A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u3i NUCLEOCAPSID PROTEIN

(Crimean-Congo
hemorrhagic
fever
orthonairovirus) 		PF02477
(Nairo_nucleo) 		3 LEU A 170
ILE A 174
ARG A 177
 None
 0.70A 4mk4B-3u3iA:
undetectable		 4mk4B-3u3iA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uk1 TRANSKETOLASE

(Burkholderia
thailandensis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		3 LEU A  90
ILE A  31
ARG A  32
 None
 0.64A 4mk4B-3uk1A:
3.3		 4mk4B-3uk1A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wgp VITAMIN D3 RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		3 LEU A 351
ILE A 355
ARG A 358
 None
 0.64A 4mk4B-3wgpA:
undetectable		 4mk4B-3wgpA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1l CRISPR SYSTEM CMR
SUBUNIT CMR2

(Pyrococcus
furiosus) 		PF12469
(DUF3692) 		3 LEU A 242
ILE A 233
ARG A 731
 None
 0.71A 4mk4B-3x1lA:
undetectable		 4mk4B-3x1lA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zq4 RIBONUCLEASE J 1

(Bacillus
subtilis) 		PF00753
(Lactamase_B)
PF07521
(RMMBL) 		3 LEU A 461
ILE A 460
ARG A 456
 None
 0.71A 4mk4B-3zq4A:
undetectable		 4mk4B-3zq4A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5o BIFUNCTIONAL PROTEIN
FOLD

(Pseudomonas
aeruginosa) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		3 LEU A  15
ILE A  19
ARG A  22
 None
 0.70A 4mk4B-4a5oA:
3.5		 4mk4B-4a5oA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b0a TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1,
LINKER,
TATA-BOX-BINDING
PROTEIN

(Saccharomyces
cerevisiae) 		PF00352
(TBP) 		3 LEU A 305
ILE A 294
ARG A 296
 None
None
GOL  A1241 (-3.5A)
 0.70A 4mk4B-4b0aA:
undetectable		 4mk4B-4b0aA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d25 BMVLG PROTEIN

(Bombyx mori) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		3 LEU A 474
ILE A 461
ARG A 470
 None
None
C  D   4 ( 3.0A)
 0.71A 4mk4B-4d25A:
3.4		 4mk4B-4d25A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i34 ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLPX

(Escherichia
coli) 		PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		3 LEU A 254
ILE A 258
ARG A 261
 None
 0.70A 4mk4B-4i34A:
undetectable		 4mk4B-4i34A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jbd PROLINE RACEMASE

(Pseudomonas
putida) 		PF05544
(Pro_racemase) 		3 LEU A 182
ILE A 264
ARG A 221
 None
 0.70A 4mk4B-4jbdA:
undetectable		 4mk4B-4jbdA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4om8 3-HYDROXYBUTYRYL-COA
DEHYDROGENASE

(Mesorhizobium
japonicum) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		3 LEU A  10
ILE A  38
ARG A  42
 None
 0.62A 4mk4B-4om8A:
3.7		 4mk4B-4om8A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2h PROLINE RACEMASE
PROTEIN

(Agrobacterium
tumefaciens) 		PF05544
(Pro_racemase) 		3 LEU A 197
ILE A 283
ARG A 240
 None
 0.68A 4mk4B-4q2hA:
undetectable		 4mk4B-4q2hA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1c EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT C

(Saccharomyces
cerevisiae) 		PF01399
(PCI)
PF05470
(eIF-3c_N) 		3 LEU C 258
ILE C 262
ARG C 265
 None
 0.67A 4mk4B-4u1cC:
undetectable		 4mk4B-4u1cC:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uer EIF3C

(Lachancea
kluyveri) 		PF00189
(Ribosomal_S3_C)
PF07650
(KH_2) 		3 LEU c 258
ILE c 262
ARG c 265
 None
 0.67A 4mk4B-4uerc:
undetectable		 4mk4B-4uerc:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsi MAGUK P55 SUBFAMILY
MEMBER 5

(Homo sapiens) 		PF00595
(PDZ)
PF00625
(Guanylate_kin)
PF07653
(SH3_2) 		3 LEU A 574
ILE A 572
ARG A 506
 None
 0.70A 4mk4B-4wsiA:
4.0		 4mk4B-4wsiA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x7m TARM

(Staphylococcus
aureus) 		PF00534
(Glycos_transf_1) 		3 LEU A  88
ILE A  92
ARG A  95
 None
 0.58A 4mk4B-4x7mA:
3.1		 4mk4B-4x7mA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xeu TRANSKETOLASE

(Pseudomonas
aeruginosa) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		3 LEU A  70
ILE A  11
ARG A  12
 None
 0.58A 4mk4B-4xeuA:
2.2		 4mk4B-4xeuA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9l PROTEIN ACDH-11,
ISOFORM B

(Caenorhabditis
elegans) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M) 		3 LEU A 520
ILE A 586
ARG A 551
 None
 0.64A 4mk4B-4y9lA:
undetectable		 4mk4B-4y9lA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zze SUGAR BINDING
PROTEIN OF ABC
TRANSPORTER SYSTEM

(Bifidobacterium
animalis) 		PF01547
(SBP_bac_1) 		3 LEU A 160
ILE A 345
ARG A 346
 None
 0.56A 4mk4B-4zzeA:
undetectable		 4mk4B-4zzeA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5z PTLCIB4 H88A MUTANT

(Phaeodactylum
tricornutum) 		no annotation 3 LEU A  97
ILE A 225
ARG A 251
 None
 0.63A 4mk4B-5b5zA:
undetectable		 4mk4B-5b5zA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c4g PHOSPHATIDYLINOSITOL
4-KINASE BETA

(Homo sapiens) 		PF00454
(PI3_PI4_kinase) 		3 LEU E 719
ILE E 723
ARG E 726
 None
 0.51A 4mk4B-5c4gE:
undetectable		 4mk4B-5c4gE:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e5w HEMAGGLUTININ-ESTERA
SE

(Influenza D
virus) 		PF00509
(Hemagglutinin)
PF08720
(Hema_stalk) 		3 LEU B 119
ILE B 123
ARG B 126
 None
 0.60A 4mk4B-5e5wB:
undetectable		 4mk4B-5e5wB:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jcp ARF-GAP WITH RHO-GAP
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN
3,LINKER,TRANSFORMIN
G PROTEIN RHOA

(Homo sapiens;
synthetic
construct) 		no annotation 3 LEU B 114
ILE B 151
ARG B 150
 None
 0.66A 4mk4B-5jcpB:
4.0		 4mk4B-5jcpB:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jj7 ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE FICD
HOMOLOG

(Caenorhabditis
elegans) 		PF02661
(Fic) 		3 LEU A 417
ILE A 421
ARG A 424
 None
 0.60A 4mk4B-5jj7A:
undetectable		 4mk4B-5jj7A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jyg ACTIN-LIKE ATPASE

(Magnetospirillum
magneticum) 		PF06723
(MreB_Mbl) 		3 LEU A 196
ILE A 200
ARG A 203
 None
 0.65A 4mk4B-5jygA:
undetectable		 4mk4B-5jygA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kc1 AUTOPHAGY-RELATED
PROTEIN 38

(Saccharomyces
cerevisiae) 		no annotation 3 LEU C 130
ILE C 134
ARG C 137
 None
NO3  C 302 (-4.5A)
NO3  C 302 ( 3.4A)
 0.55A 4mk4B-5kc1C:
undetectable		 4mk4B-5kc1C:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kes DNA DAMAGE-INDUCIBLE
PROTEIN 1

(Saccharomyces
cerevisiae) 		no annotation 3 LEU A 132
ILE A 136
ARG A 139
 None
 0.60A 4mk4B-5kesA:
undetectable		 4mk4B-5kesA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l5n PLEXIN-A4

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG) 		3 LEU A 118
ILE A 127
ARG A 125
 LEU  A 118 ( 0.5A)
ILE  A 127 ( 0.6A)
ARG  A 125 ( 0.6A)
 0.67A 4mk4B-5l5nA:
undetectable		 4mk4B-5l5nA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m59 PRE-MRNA SPLICING
HELICASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		3 LEU A1921
ILE A1924
ARG A1923
 None
 0.71A 4mk4B-5m59A:
2.9		 4mk4B-5m59A:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzy GLUTACONATE
COA-TRANSFERASE
FAMILY, SUBUNIT A

(Myxococcus
xanthus) 		PF01144
(CoA_trans) 		3 LEU A 163
ILE A 194
ARG A 192
 None
 0.71A 4mk4B-5mzyA:
undetectable		 4mk4B-5mzyA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szj MICAL
C-TERMINAL-LIKE
PROTEIN

(Homo sapiens) 		PF12130
(DUF3585) 		3 LEU B 653
ILE B 657
ARG B 660
 None
None
PEG  B 701 (-3.4A)
 0.64A 4mk4B-5szjB:
undetectable		 4mk4B-5szjB:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u08 AAC3-I

(uncultured
bacterium) 		PF00583
(Acetyltransf_1) 		3 LEU A  48
ILE A  25
ARG A  29
 None
 0.67A 4mk4B-5u08A:
undetectable		 4mk4B-5u08A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u22 N2152

(Neocallimastix
frontalis) 		PF01229
(Glyco_hydro_39) 		3 LEU A 111
ILE A 114
ARG A  80
 None
 0.61A 4mk4B-5u22A:
undetectable		 4mk4B-5u22A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 3 LEU A 632
ILE A 555
ARG A 554
 None
 0.67A 4mk4B-5uc1A:
undetectable		 4mk4B-5uc1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb CELL DIVISION CYCLE
PROTEIN CDT1

(Saccharomyces
cerevisiae) 		PF16679
(CDT1_C) 		3 LEU 8 305
ILE 8 304
ARG 8 300
 None
 0.66A 4mk4B-5udb8:
undetectable		 4mk4B-5udb8:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uxg ALDEHYDE
DEFORMYLATING
OXYGENASE

(Sulfurisphaera
tokodaii) 		no annotation 3 LEU A 114
ILE A 109
ARG A 105
 None
 0.70A 4mk4B-5uxgA:
undetectable		 4mk4B-5uxgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wyr TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Pseudomonas
aeruginosa) 		no annotation 3 LEU A 242
ILE A 246
ARG A 249
 None
 0.63A 4mk4B-5wyrA:
undetectable		 4mk4B-5wyrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5o RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza B
virus) 		no annotation 3 LEU B 674
ILE B 673
ARG B 669
 None
U  R  12 ( 4.2A)
None
 0.62A 4mk4B-6f5oB:
undetectable		 4mk4B-6f5oB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gk6 -

(-) 		no annotation 3 LEU A 175
ILE A 174
ARG A 170
 None
 0.72A 4mk4B-6gk6A:
undetectable		 4mk4B-6gk6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gl3 -

(-) 		no annotation 3 LEU A 734
ILE A 738
ARG A 741
 None
 0.46A 4mk4B-6gl3A:
undetectable		 4mk4B-6gl3A:
undetectable