SIMILAR PATTERNS OF AMINO ACIDS FOR 4MK4_B_CHDB502_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aos ARGININOSUCCINATE
LYASE

(Homo sapiens) 		PF00206
(Lyase_1)
PF14698
(ASL_C2) 		4 PHE A 238
MET A 125
ARG A 236
VAL A 117
 None
 1.42A 4mk4B-1aosA:
undetectable		 4mk4B-1aosA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dcn DELTA 2 CRYSTALLIN

(Anas
platyrhynchos) 		PF00206
(Lyase_1)
PF14698
(ASL_C2) 		4 PHE A 240
MET A 127
ARG A 238
VAL A 119
 None
 1.30A 4mk4B-1dcnA:
undetectable		 4mk4B-1dcnA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g7c ELONGATION FACTOR
1-ALPHA

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		4 PHE A 338
MET A 408
ILE A 436
VAL A 424
 None
 1.32A 4mk4B-1g7cA:
undetectable		 4mk4B-1g7cA:
21.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae) 		PF00762
(Ferrochelatase) 		4 PHE A  63
ILE A  83
ARG A  87
VAL A 277
 None
 0.78A 4mk4B-1lbqA:
48.0		 4mk4B-1lbqA:
49.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lkd BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE

(Paraburkholderia
xenovorans) 		PF00903
(Glyoxalase) 		4 PHE A 147
MET A   9
ILE A 208
ARG A 149
 None
 1.37A 4mk4B-1lkdA:
undetectable		 4mk4B-1lkdA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2w MANNITOL
DEHYDROGENASE

(Pseudomonas
fluorescens) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		4 PHE A 455
ILE A 454
ARG A 430
VAL A 438
 None
 1.40A 4mk4B-1m2wA:
1.6		 4mk4B-1m2wA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mld MALATE DEHYDROGENASE

(Sus scrofa) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 PHE A 156
ILE A 206
ARG A 152
VAL A 213
 None
None
CIT  A 375 (-2.8A)
None
 1.24A 4mk4B-1mldA:
2.3		 4mk4B-1mldA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1quq PROTEIN (REPLICATION
PROTEIN A 14 KD
SUBUNIT)

(Homo sapiens) 		PF08661
(Rep_fac-A_3) 		4 MET B  16
ILE B 106
ARG B  11
VAL B  28
 None
 1.40A 4mk4B-1quqB:
undetectable		 4mk4B-1quqB:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
LARGE SUBUNIT

(Pseudomonas
putida) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 PHE B 602
ILE B 585
ARG B 565
VAL B 529
 None
 1.40A 4mk4B-1t3qB:
undetectable		 4mk4B-1t3qB:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t4b ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Escherichia
coli) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 PHE A 130
MET A 362
ARG A  86
ARG A 128
 None
 1.23A 4mk4B-1t4bA:
2.7		 4mk4B-1t4bA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txk GLUCANS BIOSYNTHESIS
PROTEIN G

(Escherichia
coli) 		PF04349
(MdoG) 		4 PHE A 427
MET A 488
ILE A 425
ARG A 407
 None
 1.09A 4mk4B-1txkA:
undetectable		 4mk4B-1txkA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ueq MEMBRANE ASSOCIATED
GUANYLATE KINASE
INVERTED-2 (MAGI-2)

(Homo sapiens) 		PF00595
(PDZ) 		4 PHE A  34
MET A  63
ILE A  36
VAL A  98
 None
 1.38A 4mk4B-1ueqA:
undetectable		 4mk4B-1ueqA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v10 LACCASE

(Rigidoporus
microporus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 PHE A 216
MET A 223
ILE A 205
VAL A 193
 None
 1.30A 4mk4B-1v10A:
undetectable		 4mk4B-1v10A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkx PROTEIN (NF-KAPPA B
P50 SUBUNIT)

(Mus musculus) 		PF00554
(RHD_DNA_bind)
PF16179
(RHD_dimer) 		4 PHE B 611
MET B 553
ILE B 580
VAL B 627
 None
 1.39A 4mk4B-1vkxB:
undetectable		 4mk4B-1vkxB:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xnj BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1

(Homo sapiens) 		no annotation 4 PHE B 605
MET B 572
ILE B 586
ARG B 590
 None
 1.35A 4mk4B-1xnjB:
3.3		 4mk4B-1xnjB:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yhu GIANT HEMOGLOBINS B
CHAIN

(Riftia
pachyptila) 		PF00042
(Globin) 		4 PHE B  61
ILE B  56
ARG B  45
VAL B 109
 None
None
None
HEM  B 160 (-4.5A)
 1.29A 4mk4B-1yhuB:
undetectable		 4mk4B-1yhuB:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ywg GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Plasmodium
falciparum) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 PHE O  11
MET O  38
ILE O  33
VAL O  60
 None
 0.97A 4mk4B-1ywgO:
2.8		 4mk4B-1ywgO:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a4a DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Plasmodium
yoelii) 		PF01791
(DeoC) 		4 PHE A  69
ILE A  62
ARG A  32
VAL A  50
 None
 1.34A 4mk4B-2a4aA:
undetectable		 4mk4B-2a4aA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2crf RAN BINDING PROTEIN
3

(Homo sapiens) 		PF00638
(Ran_BP1) 		4 ILE A  82
ARG A  80
ARG A  49
VAL A  47
 None
 1.36A 4mk4B-2crfA:
undetectable		 4mk4B-2crfA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ctz O-ACETYL-L-HOMOSERIN
E SULFHYDRYLASE

(Thermus
thermophilus) 		PF01053
(Cys_Met_Meta_PP) 		4 PHE A 332
ILE A 160
ARG A 327
VAL A 179
 None
 1.29A 4mk4B-2ctzA:
2.9		 4mk4B-2ctzA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dgk GLUTAMATE
DECARBOXYLASE BETA

(Escherichia
coli) 		PF00282
(Pyridoxal_deC) 		4 PHE A 230
ILE A 236
ARG A 144
VAL A 158
 None
 1.39A 4mk4B-2dgkA:
4.2		 4mk4B-2dgkA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e9q 11S GLOBULIN SUBUNIT
BETA

(Cucurbita
maxima) 		PF00190
(Cupin_1) 		4 PHE A 399
MET A  65
ILE A 397
ARG A 326
 None
 1.32A 4mk4B-2e9qA:
undetectable		 4mk4B-2e9qA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ewc CONSERVED
HYPOTHETICAL PROTEIN

(Streptococcus
pyogenes) 		no annotation 4 PHE A  87
MET A  66
ILE A  83
ARG A  86
 None
 1.30A 4mk4B-2ewcA:
undetectable		 4mk4B-2ewcA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ft3 BIGLYCAN

(Bos taurus) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		4 PHE A 316
ILE A 325
ARG A 322
VAL A 306
 None
 1.33A 4mk4B-2ft3A:
undetectable		 4mk4B-2ft3A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnh DNA POLYMERASE III
ALPHA SUBUNIT

(Escherichia
coli) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 PHE A 888
ILE A 816
ARG A 853
VAL A 841
 None
 1.22A 4mk4B-2hnhA:
undetectable		 4mk4B-2hnhA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n82 RNA BINDING PROTEIN
FOX-1 HOMOLOG 1

(Homo sapiens) 		PF00076
(RRM_1) 		4 PHE B 163
ILE B 143
ARG B 134
VAL B 121
 None
 1.36A 4mk4B-2n82B:
undetectable		 4mk4B-2n82B:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nz4 U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN A

(Homo sapiens) 		PF00076
(RRM_1) 		4 PHE A  77
MET A  82
ILE A  33
VAL A  45
 None
 1.04A 4mk4B-2nz4A:
undetectable		 4mk4B-2nz4A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pi2 REPLICATION PROTEIN
A 14 KDA SUBUNIT

(Homo sapiens) 		PF08661
(Rep_fac-A_3) 		4 MET E  16
ILE E 106
ARG E  11
VAL E  28
 None
 1.41A 4mk4B-2pi2E:
undetectable		 4mk4B-2pi2E:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2plj LYSINE/ORNITHINE
DECARBOXYLASE

(Vibrio
vulnificus) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 PHE A 128
ILE A 117
ARG A 118
VAL A  92
 None
 1.15A 4mk4B-2pljA:
undetectable		 4mk4B-2pljA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyy IONOTROPIC GLUTAMATE
RECEPTOR BACTERIAL
HOMOLOGUE

(Nostoc
punctiforme) 		PF00497
(SBP_bac_3) 		4 PHE A  81
ILE A  71
ARG A  75
VAL A  50
 None
None
GLU  A1620 (-2.9A)
GLU  A1620 (-4.9A)
 1.32A 4mk4B-2pyyA:
undetectable		 4mk4B-2pyyA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzp ACYLAMINO-ACID-RELEA
SING ENZYME

(Aeropyrum
pernix) 		PF00326
(Peptidase_S9) 		4 MET A 450
ILE A 411
ARG A 398
VAL A 346
 None
 1.37A 4mk4B-2qzpA:
3.6		 4mk4B-2qzpA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rcd UNCHARACTERIZED
PROTEIN

(Pectobacterium
atrosepticum) 		PF11533
(DUF3225) 		4 PHE A  38
ILE A  59
ARG A  46
VAL A 123
 None
 1.30A 4mk4B-2rcdA:
undetectable		 4mk4B-2rcdA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rrb CDNA FLJ40872 FIS,
CLONE TUTER2000283,
HIGHLY SIMILAR TO
HOMO SAPIENS
TRANSFORMER-2-BETA
(SFRS10) GENE

(Homo sapiens) 		PF00076
(RRM_1) 		4 PHE A 166
ILE A 144
ARG A 135
VAL A 122
 None
 1.23A 4mk4B-2rrbA:
undetectable		 4mk4B-2rrbA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsa MOSQUITOCIDAL TOXIN

(Lysinibacillus
sphaericus) 		PF05588
(Botulinum_HA-17)
PF14200
(RicinB_lectin_2) 		4 PHE A 248
ILE A 225
ARG A 210
VAL A 296
 None
 1.31A 4mk4B-2vsaA:
undetectable		 4mk4B-2vsaA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxy CELL DIVISION
PROTEIN FTSZ

(Bacillus
subtilis) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		4 MET A 226
ARG A  29
ARG A 191
VAL A 307
 None
 1.11A 4mk4B-2vxyA:
4.1		 4mk4B-2vxyA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vy8 POLYMERASE BASIC
PROTEIN 2

(Influenza A
virus) 		PF00604
(Flu_PB2) 		4 PHE A 600
MET A 603
ILE A 615
VAL A 649
 None
 1.38A 4mk4B-2vy8A:
undetectable		 4mk4B-2vy8A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnb -

(Sus scrofa) 		PF00777
(Glyco_transf_29) 		4 PHE A 279
ILE A 283
ARG A 143
VAL A 131
 None
 1.01A 4mk4B-2wnbA:
undetectable		 4mk4B-2wnbA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yne GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE

(Plasmodium
vivax) 		PF01233
(NMT)
PF02799
(NMT_C) 		4 PHE A 290
MET A 256
ILE A 286
VAL A 339
 None
 1.23A 4mk4B-2yneA:
undetectable		 4mk4B-2yneA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ypd PROBABLE JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION PROT
EIN 2C

(Homo sapiens) 		PF02373
(JmjC) 		4 PHE A2367
ILE A2451
ARG A2379
VAL A2349
 None
 1.28A 4mk4B-2ypdA:
undetectable		 4mk4B-2ypdA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2f DNA POLYMERASE
SLIDING CLAMP

(Pyrococcus
furiosus) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 PHE B 157
MET B 227
ILE B 155
VAL B 208
 None
 1.31A 4mk4B-3a2fB:
undetectable		 4mk4B-3a2fB:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahi XYLULOSE
5-PHOSPHATE/FRUCTOSE
6-PHOSPHATE
PHOSPHOKETOLASE

(Bifidobacterium
breve) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		4 PHE A 729
ILE A 720
ARG A 723
VAL A 672
 None
 1.15A 4mk4B-3ahiA:
3.4		 4mk4B-3ahiA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai7 XYLULOSE-5-PHOSPHATE
/FRUCTOSE-6-PHOSPHAT
E PHOSPHOKETOLASE

(Bifidobacterium
longum) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		4 PHE A 729
ILE A 720
ARG A 723
VAL A 672
 None
 1.12A 4mk4B-3ai7A:
3.6		 4mk4B-3ai7A:
17.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		5 PHE A  93
MET A  99
ILE A 111
ARG A 114
VAL A 305
 CHD  A   1 ( 4.7A)
CHD  A   2 (-4.0A)
CHD  A   2 ( 4.7A)
CHD  A   2 (-3.6A)
CHD  A   1 ( 4.9A)
 0.59A 4mk4B-3aqiA:
59.3		 4mk4B-3aqiA:
99.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cps GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Cryptosporidium
parvum) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 PHE A  25
MET A  52
ILE A  47
VAL A  74
 None
 1.17A 4mk4B-3cpsA:
3.5		 4mk4B-3cpsA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d5o SERUM AMYLOID
P-COMPONENT

(Homo sapiens) 		PF00354
(Pentaxin) 		4 PHE A  50
MET A 159
ILE A 131
VAL A 125
 None
 1.37A 4mk4B-3d5oA:
undetectable		 4mk4B-3d5oA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddu PROLYL ENDOPEPTIDASE

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 PHE A 173
MET A 235
ILE A 591
ARG A 643
 552  A 901 (-3.5A)
552  A 901 (-3.6A)
552  A 901 ( 4.2A)
552  A 901 (-3.9A)
 1.31A 4mk4B-3dduA:
4.3		 4mk4B-3dduA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb6 BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 3

(Homo sapiens) 		PF13920
(zf-C3HC4_3) 		4 PHE A 569
ILE A 595
ARG A 586
VAL A 559
 None
 1.27A 4mk4B-3eb6A:
undetectable		 4mk4B-3eb6A:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3foa TAIL SHEATH PROTEIN
GP18

(Escherichia
virus T4) 		PF04984
(Phage_sheath_1)
PF17481
(Phage_sheath_1N) 		4 PHE A 373
ILE A 396
ARG A 400
VAL A 368
 None
 1.42A 4mk4B-3foaA:
2.0		 4mk4B-3foaA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gd7 FUSION COMPLEX OF
CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR, RESIDUES
1193-1427 AND
MALTOSE/MALTODEXTRIN
IMPORT ATP-BINDING
PROTEIN MALK,
RESIDUES 219-371

(Escherichia
coli;
Homo sapiens) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		4 PHE A1300
MET A1354
ILE A1328
VAL A1345
 None
 1.37A 4mk4B-3gd7A:
undetectable		 4mk4B-3gd7A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gqc DNA REPAIR PROTEIN
REV1

(Homo sapiens) 		PF00817
(IMS)
PF11799
(IMS_C) 		4 PHE A 590
MET A 420
ILE A 579
ARG A 386
 None
 1.22A 4mk4B-3gqcA:
undetectable		 4mk4B-3gqcA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i45 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN

(Rhodospirillum
rubrum) 		PF13458
(Peripla_BP_6) 		4 PHE A 300
ILE A   6
ARG A   7
VAL A  98
 None
 1.42A 4mk4B-3i45A:
3.7		 4mk4B-3i45A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iib PEPTIDASE M28

(Shewanella
amazonensis) 		PF04389
(Peptidase_M28) 		4 PHE A 449
MET A 379
ARG A 316
VAL A 367
 None
 1.37A 4mk4B-3iibA:
2.2		 4mk4B-3iibA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2n TAIL SHEATH PROTEIN
GP18

(Escherichia
virus T4) 		PF04984
(Phage_sheath_1)
PF17481
(Phage_sheath_1N)
PF17482
(Phage_sheath_1C) 		4 PHE U 373
ILE U 396
ARG U 400
VAL U 368
 None
 1.42A 4mk4B-3j2nU:
undetectable		 4mk4B-3j2nU:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
PPI1

(Schizosaccharomyces
pombe) 		PF01423
(LSM) 		4 PHE d  43
MET d 132
ILE d 149
VAL d 122
 None
 1.40A 4mk4B-3jb9d:
undetectable		 4mk4B-3jb9d:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m49 TRANSKETOLASE

(Bacillus
anthracis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 PHE A 375
MET A 390
ILE A 368
VAL A 459
 None
 1.31A 4mk4B-3m49A:
undetectable		 4mk4B-3m49A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6q PEPTIDE DEFORMYLASE
1B

(Arabidopsis
thaliana) 		PF01327
(Pep_deformylase) 		4 PHE A  58
MET A  56
ILE A 130
VAL A 107
 None
None
BB2  A 194 (-4.1A)
None
 1.35A 4mk4B-3m6qA:
undetectable		 4mk4B-3m6qA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q6a UNCHARACTERIZED
PROTEIN

(Staphylococcus
saprophyticus) 		PF08327
(AHSA1) 		4 PHE A  20
MET A 115
ILE A  79
VAL A   9
 None
 1.30A 4mk4B-3q6aA:
undetectable		 4mk4B-3q6aA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rre PUTATIVE
UNCHARACTERIZED
PROTEIN

(Thermotoga
maritima) 		PF01256
(Carb_kinase)
PF03853
(YjeF_N) 		4 MET A   1
ILE A 196
ARG A  22
VAL A 200
 None
 1.36A 4mk4B-3rreA:
3.4		 4mk4B-3rreA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3si1 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE

(Mus musculus) 		PF04389
(Peptidase_M28) 		4 PHE A 199
ILE A 197
ARG A 195
VAL A 318
 None
 1.21A 4mk4B-3si1A:
2.0		 4mk4B-3si1A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sth GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Toxoplasma
gondii) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 PHE A  10
MET A  37
ILE A  32
VAL A  59
 None
 1.02A 4mk4B-3sthA:
2.9		 4mk4B-3sthA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t20 CIS-ACONITATE PORIN
OPDH

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		4 PHE A  16
ILE A 383
ARG A 363
ARG A 381
 None
 1.19A 4mk4B-3t20A:
undetectable		 4mk4B-3t20A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tp2 PRE-MRNA-SPLICING
FACTOR CWC2

(Saccharomyces
cerevisiae) 		PF00076
(RRM_1)
PF16131
(Torus) 		4 PHE A 186
ILE A 170
ARG A 161
VAL A 139
 None
 1.38A 4mk4B-3tp2A:
undetectable		 4mk4B-3tp2A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttl POLYAMINE TRANSPORT
PROTEIN

(Pseudomonas
aeruginosa) 		PF13416
(SBP_bac_8) 		4 PHE A 290
MET A 275
ILE A  31
VAL A 303
 None
 1.37A 4mk4B-3ttlA:
undetectable		 4mk4B-3ttlA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3upy OXIDOREDUCTASE

(Brucella
abortus) 		PF03447
(NAD_binding_3) 		4 MET A 137
ILE A 146
ARG A 429
VAL A 231
 None
 1.13A 4mk4B-3upyA:
3.8		 4mk4B-3upyA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x0u UNCHARACTERIZED
PROTEIN

(Vibrio
parahaemolyticus) 		PF03945
(Endotoxin_N) 		4 PHE A 378
MET A 409
ILE A 311
VAL A 325
 None
 1.35A 4mk4B-3x0uA:
undetectable		 4mk4B-3x0uA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E

(Linum
nodiflorum) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		4 PHE A 198
MET A 299
ILE A 218
VAL A 357
 None
 1.25A 4mk4B-4eviA:
2.0		 4mk4B-4eviA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hv4 UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE

(Yersinia pestis) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 MET A 406
ILE A 429
ARG A 432
VAL A 359
 None
 1.41A 4mk4B-4hv4A:
2.8		 4mk4B-4hv4A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l9a PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1393C

(Streptococcus
mutans) 		no annotation 4 PHE A  29
ILE A  46
ARG A  21
VAL A 265
 None
 1.31A 4mk4B-4l9aA:
3.8		 4mk4B-4l9aA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ll8 MYOSIN-4

(Saccharomyces
cerevisiae) 		PF01843
(DIL) 		4 PHE A1283
MET A1183
ARG A1345
VAL A1292
 None
 1.42A 4mk4B-4ll8A:
undetectable		 4mk4B-4ll8A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9o PUTATIVE ALDO/KETO
REDUCTASE

(Salmonella
enterica) 		PF00248
(Aldo_ket_red) 		4 MET A 124
ILE A   7
ARG A 205
VAL A 181
 None
 1.41A 4mk4B-4r9oA:
undetectable		 4mk4B-4r9oA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvo PHENYLACETATE-COENZY
ME A LIGASE

(Bacteroides
thetaiotaomicron) 		PF00501
(AMP-binding)
PF14535
(AMP-binding_C_2) 		4 PHE A 237
MET A 257
ILE A 325
VAL A 266
 ADP  A 502 (-4.7A)
ADP  A 502 ( 4.3A)
ADP  A 502 ( 4.3A)
None
 1.33A 4mk4B-4rvoA:
5.4		 4mk4B-4rvoA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u10 POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE

(Aggregatibacter
actinomycetemcomitans) 		PF01522
(Polysacc_deac_1) 		4 PHE A 254
ILE A 229
ARG A 228
VAL A  73
 None
 1.25A 4mk4B-4u10A:
undetectable		 4mk4B-4u10A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u39 CELL DIVISION
PROTEIN FTSZ

(Bacillus
subtilis) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		4 MET A 226
ARG A  29
ARG A 191
VAL A 307
 None
 1.17A 4mk4B-4u39A:
3.3		 4mk4B-4u39A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ufs LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5

(Homo sapiens) 		PF00560
(LRR_1)
PF01462
(LRRNT)
PF13855
(LRR_8) 		4 PHE A 182
MET A 191
ILE A 177
VAL A 129
 None
 1.41A 4mk4B-4ufsA:
undetectable		 4mk4B-4ufsA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xb6 ALPHA-D-RIBOSE
1-METHYLPHOSPHONATE
5-TRIPHOSPHATE
SYNTHASE SUBUNIT
PHNH
ALPHA-D-RIBOSE
1-METHYLPHOSPHONATE
5-PHOSPHATE C-P
LYASE

(Escherichia
coli;
Escherichia
coli) 		PF05845
(PhnH)
PF06007
(PhnJ) 		4 PHE B  18
ARG B  20
ARG B  19
VAL D 103
 None
 1.41A 4mk4B-4xb6B:
undetectable		 4mk4B-4xb6B:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xin LPQH ORTHOLOGUE

(Mycobacterium
avium) 		PF05481
(Myco_19_kDa) 		4 PHE A  98
MET A  91
ILE A  44
ARG A  42
 None
 1.34A 4mk4B-4xinA:
undetectable		 4mk4B-4xinA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c91 E3 UBIQUITIN-PROTEIN
LIGASE NEDD4

(Homo sapiens) 		PF00632
(HECT) 		4 MET A 663
ILE A 745
ARG A 744
VAL A 677
 None
 1.41A 4mk4B-5c91A:
undetectable		 4mk4B-5c91A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cdo DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B

(Staphylococcus
aureus) 		PF00986
(DNA_gyraseB_C)
PF01751
(Toprim) 		4 MET B 528
ILE B 482
ARG B 479
VAL B 464
 None
 1.25A 4mk4B-5cdoB:
4.8		 4mk4B-5cdoB:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5du2 ESPG2
GLYCOSYLTRANSFERASE

(Actinomadura
verrucosospora) 		PF00201
(UDPGT) 		4 PHE A 196
ILE A 192
ARG A 212
VAL A 328
 None
 1.25A 4mk4B-5du2A:
4.3		 4mk4B-5du2A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e3x THERMOSTABLE
CARBOXYPEPTIDASE 1

(Fervidobacterium
islandicum) 		PF02074
(Peptidase_M32) 		4 PHE A 401
ILE A 358
ARG A 131
VAL A 367
 None
 1.28A 4mk4B-5e3xA:
undetectable		 4mk4B-5e3xA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fzo PROBABLE JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION PROT
EIN 2C

(Homo sapiens) 		PF02373
(JmjC) 		4 PHE A2367
ILE A2451
ARG A2379
VAL A2349
 None
 1.28A 4mk4B-5fzoA:
undetectable		 4mk4B-5fzoA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jd9 SPORE COAT PROTEIN H

(Bacillus cereus) 		PF08757
(CotH) 		4 PHE A  93
MET A 304
ILE A  97
ARG A 211
 None
 1.13A 4mk4B-5jd9A:
undetectable		 4mk4B-5jd9A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jpn COMPLEMENT C4-A
COMPLEMENT C4-A

(Homo sapiens;
Homo sapiens) 		PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF00207
(A2M)
PF01821
(ANATO)
PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		4 PHE A 202
MET B1054
ARG A 157
VAL A 233
 None
 1.11A 4mk4B-5jpnA:
undetectable		 4mk4B-5jpnA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kc9 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-1

(Mus musculus) 		PF01094
(ANF_receptor) 		4 PHE A 334
MET A 365
ILE A  24
VAL A  91
 None
 1.05A 4mk4B-5kc9A:
undetectable		 4mk4B-5kc9A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2e GLUTAMATE RECEPTOR
IONOTROPIC,
DELTA-2,GLUTAMATE
RECEPTOR IONOTROPIC,
DELTA-2

(Rattus
norvegicus) 		PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		4 PHE A 338
MET A 369
ILE A  27
VAL A  94
 None
 1.36A 4mk4B-5l2eA:
4.2		 4mk4B-5l2eA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkt RENIN-1

(Mus musculus) 		no annotation 4 PHE A  80
MET A 173
ILE A  11
VAL A 140
 None
 1.08A 4mk4B-5mktA:
undetectable		 4mk4B-5mktA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlg RENIN

(Rattus
norvegicus) 		no annotation 4 PHE A  80
MET A 173
ILE A  11
VAL A 140
 None
 1.13A 4mk4B-5mlgA:
undetectable		 4mk4B-5mlgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN

(Thermothelomyces
thermophila) 		PF07992
(Pyr_redox_2) 		4 PHE A 362
MET A 359
ARG A 426
VAL A 134
 None
None
FAD  A 700 ( 4.2A)
FAD  A 700 (-4.4A)
 1.22A 4mk4B-5mq6A:
2.3		 4mk4B-5mq6A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n2u NUCLEOPROTEIN

(Influenza D
virus) 		no annotation 4 PHE A 500
MET A 365
ARG A 368
VAL A 373
 None
 1.27A 4mk4B-5n2uA:
undetectable		 4mk4B-5n2uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus) 		PF02538
(Hydantoinase_B) 		4 ILE A 683
ARG A 684
ARG A 680
VAL A 639
 None
 1.29A 4mk4B-5svcA:
undetectable		 4mk4B-5svcA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u84 ACID CERAMIDASE

(Balaenoptera
acutorostrata) 		no annotation 4 PHE A 191
MET A 210
ILE A  52
ARG A  61
 None
None
None
IOD  A 430 ( 4.3A)
 1.42A 4mk4B-5u84A:
undetectable		 4mk4B-5u84A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vgr ATLASTIN-3

(Homo sapiens) 		PF02263
(GBP)
PF02841
(GBP_C) 		4 PHE A 210
ILE A 178
ARG A 235
VAL A 249
 None
 1.23A 4mk4B-5vgrA:
undetectable		 4mk4B-5vgrA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wbg CYTOCHROME P450 2B6

(Homo sapiens) 		no annotation 4 PHE A 311
MET A 459
ILE A 453
VAL A 324
 None
 1.13A 4mk4B-5wbgA:
undetectable		 4mk4B-5wbgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x1e ICMS
ICMW

(Legionella
pneumophila;
Legionella
pneumophila) 		PF12608
(T4bSS_IcmS)
no annotation 		4 MET A   9
ILE A  42
ARG A  45
VAL B 134
 None
 1.37A 4mk4B-5x1eA:
undetectable		 4mk4B-5x1eA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xpw AMPHIOXUS IGVJ-C2

(Branchiostoma
floridae) 		no annotation 4 PHE A  56
MET A  34
ARG A  60
VAL A  79
 None
 1.37A 4mk4B-5xpwA:
undetectable		 4mk4B-5xpwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yx2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3-LIKE

(Homo sapiens) 		no annotation 4 PHE B 368
MET B 283
ILE B 199
VAL B 321
 None
 1.30A 4mk4B-5yx2B:
undetectable		 4mk4B-5yx2B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a91 -

(-) 		no annotation 4 PHE A 142
ILE A 146
ARG A 236
VAL A 181
 None
 1.42A 4mk4B-6a91A:
undetectable		 4mk4B-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cbl NEAMINE TRANSAMINASE
NEON

(Streptomyces
fradiae) 		no annotation 4 PHE A 318
ILE A 309
ARG A 297
VAL A 348
 None
 1.23A 4mk4B-6cblA:
undetectable		 4mk4B-6cblA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cgm RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Bacillus
subtilis) 		no annotation 4 PHE A 360
ILE A 358
ARG A 350
VAL A 638
 None
None
EDO  A 803 (-4.1A)
None
 1.15A 4mk4B-6cgmA:
undetectable		 4mk4B-6cgmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6czm -

(-) 		no annotation 4 PHE A 146
MET A 158
ILE A 140
VAL A 189
 None
 1.30A 4mk4B-6czmA:
undetectable		 4mk4B-6czmA:
undetectable