SIMILAR PATTERNS OF AMINO ACIDS FOR 4MK4_A_CHDA504_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1czf | POLYGALACTURONASE II (Aspergillusniger) |
PF00295(Glyco_hydro_28) | 4 | PRO A 357SER A 358VAL A 359GLY A 332 | None | 0.89A | 4mk4A-1czfA:undetectable | 4mk4A-1czfA:19.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ep2 | DIHYDROOROTATEDEHYDROGENASE B(PYRK SUBUNIT) (Lactococcuslactis) |
PF00175(NAD_binding_1)PF10418(DHODB_Fe-S_bind) | 4 | MET B 220PRO B 124SER B 56GLY B 119 | NoneNoneFAD B 503 (-3.2A)None | 1.03A | 4mk4A-1ep2B:3.0 | 4mk4A-1ep2B:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f9a | HYPOTHETICAL PROTEINMJ0541 (Methanocaldococcusjannaschii) |
PF01467(CTP_transf_like) | 4 | PRO A 46ARG A 8VAL A 157GLY A 156 | NoneATP A 700 (-3.0A)NoneNone | 0.98A | 4mk4A-1f9aA:undetectable | 4mk4A-1f9aA:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h81 | POLYAMINE OXIDASE (Zea mays) |
PF01593(Amino_oxidase) | 4 | ARG A 356PRO A 174VAL A 177GLY A 327 | None | 0.93A | 4mk4A-1h81A:undetectable | 4mk4A-1h81A:21.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hyb | NICOTINAMIDEMONONUCLEOTIDEADENYLYLTRANSFERASE (Methanothermobacterthermautotrophicus) |
PF01467(CTP_transf_like) | 5 | ARG A 146PRO A 49ARG A 11VAL A 163GLY A 162 | NoneNoneSO4 A1759 ( 3.2A)NoneNone | 1.09A | 4mk4A-1hybA:3.3 | 4mk4A-1hybA:19.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ijx | SECRETEDFRIZZLED-RELATEDSEQUENCE PROTEIN 3 (Mus musculus) |
PF01392(Fz) | 4 | SER A 78VAL A 79VAL A 114GLY A 113 | None | 0.99A | 4mk4A-1ijxA:undetectable | 4mk4A-1ijxA:14.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ijx | SECRETEDFRIZZLED-RELATEDSEQUENCE PROTEIN 3 (Mus musculus) |
PF01392(Fz) | 4 | VAL A 79ARG A 82VAL A 114GLY A 113 | None | 0.94A | 4mk4A-1ijxA:undetectable | 4mk4A-1ijxA:14.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kcm | PHOSPHATIDYLINOSITOLTRANSFER PROTEINALPHA (Mus musculus) |
PF02121(IP_trans) | 4 | ARG A 147PRO A 12VAL A 13GLY A 175 | None | 0.98A | 4mk4A-1kcmA:undetectable | 4mk4A-1kcmA:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kkr | 3-METHYLASPARTATEAMMONIA-LYASE (Citrobacteramalonaticus) |
PF05034(MAAL_N)PF07476(MAAL_C) | 4 | ARG A 369VAL A 106VAL A 66GLY A 67 | None | 1.01A | 4mk4A-1kkrA:undetectable | 4mk4A-1kkrA:19.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l5j | ACONITATE HYDRATASE2 (Escherichiacoli) |
PF00330(Aconitase)PF06434(Aconitase_2_N)PF11791(Aconitase_B_N) | 4 | ARG A 467PRO A 55VAL A 264VAL A 57 | None | 0.88A | 4mk4A-1l5jA:2.5 | 4mk4A-1l5jA:19.25 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1lbq | FERROCHELATASE (Saccharomycescerevisiae) |
PF00762(Ferrochelatase) | 5 | ARG A 87PRO A 238VAL A 241VAL A 277GLY A 278 | None | 0.73A | 4mk4A-1lbqA:48.3 | 4mk4A-1lbqA:49.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ldm | M4 LACTATEDEHYDROGENASE (Squalusacanthias) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 4 | PRO A 269SER A 287VAL A 270GLY A 187 | None | 1.01A | 4mk4A-1ldmA:3.1 | 4mk4A-1ldmA:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mb9 | BETA-LACTAMSYNTHETASE (Streptomycesclavuligerus) |
PF00733(Asn_synthase)PF13537(GATase_7) | 4 | SER A 503VAL A 504ARG A 507VAL A 495 | None | 1.01A | 4mk4A-1mb9A:undetectable | 4mk4A-1mb9A:21.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o94 | TRIMETHYLAMINEDEHYDROGENASE (Methylophilusmethylotrophus) |
PF00724(Oxidored_FMN)PF07992(Pyr_redox_2) | 4 | VAL A 691ARG A 690VAL A 395GLY A 396 | NoneNoneADP A1731 (-4.7A)ADP A1731 (-3.4A) | 0.89A | 4mk4A-1o94A:3.0 | 4mk4A-1o94A:19.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1oh2 | SUCROSE SPECIFICPORIN (Salmonellaenterica) |
PF02264(LamB) | 4 | MET Q 258VAL Q 203VAL Q 288GLY Q 262 | None | 0.99A | 4mk4A-1oh2Q:undetectable | 4mk4A-1oh2Q:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qdb | CYTOCHROME C NITRITEREDUCTASE (Sulfurospirillumdeleyianum) |
PF02335(Cytochrom_C552) | 4 | ARG A 418PRO A 283VAL A 253GLY A 252 | SO4 A1506 (-3.5A)NoneNoneNone | 0.89A | 4mk4A-1qdbA:undetectable | 4mk4A-1qdbA:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rdk | MANNOSE-BINDINGPROTEIN-C (Rattus rattus) |
PF00059(Lectin_C) | 4 | PRO 1 213SER 1 215VAL 1 194GLY 1 195 | CL 1 3 (-4.6A)NoneNoneNone | 0.81A | 4mk4A-1rdk1:undetectable | 4mk4A-1rdk1:15.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t2f | L-LACTATEDEHYDROGENASE BCHAIN (Homo sapiens) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 4 | PRO A 272SER A 290VAL A 273GLY A 187 | None | 1.01A | 4mk4A-1t2fA:3.4 | 4mk4A-1t2fA:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u8x | MALTOSE-6'-PHOSPHATEGLUCOSIDASE (Bacillussubtilis) |
PF02056(Glyco_hydro_4)PF11975(Glyco_hydro_4C) | 4 | PRO X 174VAL X 175ARG X 190GLY X 199 | None | 1.02A | 4mk4A-1u8xX:1.8 | 4mk4A-1u8xX:20.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u8x | MALTOSE-6'-PHOSPHATEGLUCOSIDASE (Bacillussubtilis) |
PF02056(Glyco_hydro_4)PF11975(Glyco_hydro_4C) | 4 | PRO X 174VAL X 175ARG X 190GLY X 204 | None | 0.88A | 4mk4A-1u8xX:1.8 | 4mk4A-1u8xX:20.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xru | 4-DEOXY-L-THREO-5-HEXOSULOSE-URONATEKETOL-ISOMERASE (Escherichiacoli) |
PF04962(KduI) | 4 | MET A 179VAL A 171VAL A 106GLY A 107 | None | 0.98A | 4mk4A-1xruA:undetectable | 4mk4A-1xruA:19.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y7p | HYPOTHETICAL PROTEINAF1403 (Archaeoglobusfulgidus) |
PF01842(ACT) | 4 | PRO A 182SER A 174VAL A 188GLY A 155 | None | 0.99A | 4mk4A-1y7pA:3.7 | 4mk4A-1y7pA:22.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yve | ACETOHYDROXY ACIDISOMEROREDUCTASE (Spinaciaoleracea) |
PF01450(IlvC)PF07991(IlvN) | 4 | PRO I 251SER I 225VAL I 249GLY I 255 | NDP I 600 (-4.7A)NDP I 600 (-4.9A)NoneNDP I 600 (-3.9A) | 0.90A | 4mk4A-1yveI:2.8 | 4mk4A-1yveI:19.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a2l | UNKNOWN (Klebsiellapneumoniae) |
PF03928(Haem_degrading) | 4 | SER A 64VAL A 123VAL A 111GLY A 119 | None | 0.98A | 4mk4A-2a2lA:undetectable | 4mk4A-2a2lA:16.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2akj | FERREDOXIN--NITRITEREDUCTASE,CHLOROPLAST (Spinaciaoleracea) |
PF01077(NIR_SIR)PF03460(NIR_SIR_ferr) | 4 | PRO A 227VAL A 178VAL A 229GLY A 183 | None | 0.93A | 4mk4A-2akjA:undetectable | 4mk4A-2akjA:20.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bht | CYSTEINE SYNTHASE B (Escherichiacoli) |
PF00291(PALP) | 4 | MET A 95SER A 288VAL A 254GLY A 253 | None | 0.90A | 4mk4A-2bhtA:undetectable | 4mk4A-2bhtA:22.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bol | SMALL HEAT SHOCKPROTEIN (Taenia saginata) |
PF00011(HSP20) | 4 | PRO A 163SER A 165VAL A 166GLY A 256 | None | 0.86A | 4mk4A-2bolA:undetectable | 4mk4A-2bolA:23.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d1c | ISOCITRATEDEHYDROGENASE (Thermusthermophilus) |
PF00180(Iso_dh) | 4 | SER A 59VAL A 60ARG A 63GLY A 86 | None | 0.69A | 4mk4A-2d1cA:4.0 | 4mk4A-2d1cA:22.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f1s | VIRAL CASP8 ANDFADD-LIKE APOPTOSISREGULATOR (Molluscumcontagiosumvirus) |
PF01335(DED) | 4 | ARG A 166VAL A 149VAL A 103GLY A 104 | None | 1.01A | 4mk4A-2f1sA:undetectable | 4mk4A-2f1sA:20.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f6r | BIFUNCTIONALCOENZYME A SYNTHASE (Mus musculus) |
PF01121(CoaE) | 4 | MET A 224SER A 74VAL A 191GLY A 67 | None | 1.03A | 4mk4A-2f6rA:undetectable | 4mk4A-2f6rA:20.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f6r | BIFUNCTIONALCOENZYME A SYNTHASE (Mus musculus) |
PF01121(CoaE) | 4 | MET A 224VAL A 195VAL A 191GLY A 67 | None | 0.96A | 4mk4A-2f6rA:undetectable | 4mk4A-2f6rA:20.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ftw | DIHYDROPYRIMIDINEAMIDOHYDROLASE (Dictyosteliumdiscoideum) |
PF01979(Amidohydro_1) | 4 | PRO A 60SER A 378VAL A 374GLY A 400 | None | 1.01A | 4mk4A-2ftwA:undetectable | 4mk4A-2ftwA:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i6d | RNAMETHYLTRANSFERASE,TRMH FAMILY (Porphyromonasgingivalis) |
PF00588(SpoU_methylase) | 4 | ARG A 207SER A 140VAL A 143GLY A 134 | None | 0.96A | 4mk4A-2i6dA:3.1 | 4mk4A-2i6dA:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i99 | MU-CRYSTALLINHOMOLOG (Homo sapiens) |
PF02423(OCD_Mu_crystall) | 4 | SER A 87VAL A 88VAL A 146GLY A 145 | NoneNoneNDP A 502 (-3.9A)NDP A 502 (-3.0A) | 1.02A | 4mk4A-2i99A:2.5 | 4mk4A-2i99A:20.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2kfg | EH DOMAIN-CONTAININGPROTEIN 1 (Homo sapiens) |
PF12763(EF-hand_4) | 4 | PRO A 132SER A 134VAL A 46GLY A 47 | None | 0.61A | 4mk4A-2kfgA:undetectable | 4mk4A-2kfgA:13.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2kfu | RV1827 PTHR 22 (Mycobacteriumtuberculosis) |
PF00498(FHA) | 4 | ARG A 96VAL A 121VAL A 113GLY A 114 | None | 0.94A | 4mk4A-2kfuA:undetectable | 4mk4A-2kfuA:20.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2kxh | POLY(U)-BINDING-SPLICING FACTOR PUF60 (Homo sapiens) |
PF00076(RRM_1) | 4 | SER A 175VAL A 176VAL A 282GLY A 283 | None | 1.03A | 4mk4A-2kxhA:undetectable | 4mk4A-2kxhA:21.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ldx | APO-LACTATEDEHYDROGENASE (Mus musculus) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 4 | PRO A 271SER A 289VAL A 272GLY A 186 | None | 1.01A | 4mk4A-2ldxA:3.8 | 4mk4A-2ldxA:21.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o2q | FORMYLTETRAHYDROFOLATE DEHYDROGENASE (Rattusnorvegicus) |
PF00171(Aldedh) | 4 | ARG A 814SER A 698VAL A 699VAL A 724 | None | 0.97A | 4mk4A-2o2qA:undetectable | 4mk4A-2o2qA:22.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2obv | S-ADENOSYLMETHIONINESYNTHETASE ISOFORMTYPE-1 (Homo sapiens) |
PF00438(S-AdoMet_synt_N)PF02772(S-AdoMet_synt_M)PF02773(S-AdoMet_synt_C) | 4 | VAL A 359ARG A 362VAL A 324GLY A 323 | None | 0.86A | 4mk4A-2obvA:undetectable | 4mk4A-2obvA:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2okj | GLUTAMATEDECARBOXYLASE 1 (Homo sapiens) |
PF00282(Pyridoxal_deC) | 4 | MET A 261SER A 398VAL A 418GLY A 252 | NoneNoneNoneLLP A 405 ( 3.4A) | 0.93A | 4mk4A-2okjA:4.6 | 4mk4A-2okjA:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2okk | GLUTAMATEDECARBOXYLASE 2 (Homo sapiens) |
PF00282(Pyridoxal_deC) | 4 | MET A 252SER A 389VAL A 409GLY A 243 | NoneNoneNoneLLP A 396 ( 3.6A) | 1.01A | 4mk4A-2okkA:4.1 | 4mk4A-2okkA:21.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p68 | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]REDUCTASE (Aquifexaeolicus) |
PF13561(adh_short_C2) | 4 | PRO A 187VAL A 221VAL A 146GLY A 147 | None | 0.87A | 4mk4A-2p68A:3.1 | 4mk4A-2p68A:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p68 | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]REDUCTASE (Aquifexaeolicus) |
PF13561(adh_short_C2) | 4 | SER A 144VAL A 145VAL A 152GLY A 153 | None | 0.69A | 4mk4A-2p68A:3.1 | 4mk4A-2p68A:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ph3 | 3-OXOACYL-[ACYLCARRIER PROTEIN]REDUCTASE (Thermusthermophilus) |
PF13561(adh_short_C2) | 4 | PRO A 182VAL A 216VAL A 141GLY A 142 | None | 0.89A | 4mk4A-2ph3A:2.4 | 4mk4A-2ph3A:24.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q2r | GLUCOKINASE 1,PUTATIVE (Trypanosomacruzi) |
PF02685(Glucokinase) | 4 | PRO A 77SER A 79VAL A 80ARG A 83 | None | 0.87A | 4mk4A-2q2rA:undetectable | 4mk4A-2q2rA:22.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q7t | PROTEIN TRAI (Escherichiacoli) |
PF08751(TrwC) | 4 | PRO A 87SER A 89VAL A 90GLY A 222 | None | 0.88A | 4mk4A-2q7tA:undetectable | 4mk4A-2q7tA:21.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vyo | POLYSACCHARIDEDEACETYLASEDOMAIN-CONTAININGPROTEIN ECU11_0510 (Encephalitozooncuniculi) |
PF01522(Polysacc_deac_1) | 4 | VAL A 40ARG A 43VAL A 66GLY A 67 | None | 1.03A | 4mk4A-2vyoA:undetectable | 4mk4A-2vyoA:19.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x0f | WSAF (Geobacillusstearothermophilus) |
no annotation | 4 | SER A 251VAL A 252VAL A 282GLY A 301 | NoneGOL A1415 (-3.8A)TRH A 416 ( 4.4A)None | 0.90A | 4mk4A-2x0fA:3.7 | 4mk4A-2x0fA:22.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xsg | CCMAN5 (Cellulosimicrobiumcellulans) |
PF07971(Glyco_hydro_92) | 4 | ARG A 42PRO A 402SER A 350GLY A 74 | None | 1.03A | 4mk4A-2xsgA:undetectable | 4mk4A-2xsgA:19.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ycb | CLEAVAGE ANDPOLYADENYLATIONSPECIFICITY FACTOR (Methanothermobacterthermautotrophicus) |
PF07521(RMMBL)PF10996(Beta-Casp)PF16661(Lactamase_B_6)PF17214(KH_7) | 4 | PRO A 252SER A 301VAL A 298GLY A 210 | None | 0.88A | 4mk4A-2ycbA:3.8 | 4mk4A-2ycbA:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ycb | CLEAVAGE ANDPOLYADENYLATIONSPECIFICITY FACTOR (Methanothermobacterthermautotrophicus) |
PF07521(RMMBL)PF10996(Beta-Casp)PF16661(Lactamase_B_6)PF17214(KH_7) | 4 | PRO A 252VAL A 298VAL A 211GLY A 210 | None | 0.96A | 4mk4A-2ycbA:3.8 | 4mk4A-2ycbA:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z0m | 337AA LONGHYPOTHETICALATP-DEPENDENT RNAHELICASE DEAD (Sulfurisphaeratokodaii) |
PF00270(DEAD)PF00271(Helicase_C) | 4 | PRO A 251SER A 253VAL A 254ARG A 257 | None | 0.90A | 4mk4A-2z0mA:2.8 | 4mk4A-2z0mA:21.45 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3aqi | FERROCHELATASE (Homo sapiens) |
PF00762(Ferrochelatase) | 7 | MET A 99PRO A 266SER A 268VAL A 269ARG A 272VAL A 305GLY A 306 | CHD A 2 (-4.0A)CHD A 2 ( 4.5A)CHD A 2 ( 4.4A)NoneFES A 501 (-4.1A)CHD A 1 ( 4.9A)CHD A 2 ( 3.8A) | 0.33A | 4mk4A-3aqiA:59.3 | 4mk4A-3aqiA:99.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d2u | UL18 PROTEIN (Humanbetaherpesvirus5) |
PF00129(MHC_I)PF07654(C1-set) | 4 | PRO A 191SER A 211VAL A 193VAL A 188 | None | 0.98A | 4mk4A-3d2uA:undetectable | 4mk4A-3d2uA:20.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3da1 | GLYCEROL-3-PHOSPHATEDEHYDROGENASE (Bacillushalodurans) |
PF01266(DAO)PF16901(DAO_C) | 4 | SER A 58ARG A 493VAL A 253GLY A 252 | NoneNoneNoneFAD A 609 (-3.5A) | 0.82A | 4mk4A-3da1A:undetectable | 4mk4A-3da1A:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dwz | BETA-LACTAMASE (Mycobacteriumtuberculosis) |
PF13354(Beta-lactamase2) | 4 | SER A 267VAL A 271VAL A 305GLY A 304 | None | 0.97A | 4mk4A-3dwzA:undetectable | 4mk4A-3dwzA:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e7n | D-RIBOSEHIGH-AFFINITYTRANSPORT SYSTEM (Salmonellaenterica) |
PF05025(RbsD_FucU) | 4 | VAL A 57ARG A 60VAL A 48GLY A 47 | None | 0.95A | 4mk4A-3e7nA:undetectable | 4mk4A-3e7nA:14.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e7w | D-ALANINE--POLY(PHOSPHORIBITOL) LIGASESUBUNIT 1 (Bacillussubtilis) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 4 | PRO A 273SER A 275VAL A 276GLY A 435 | None | 0.52A | 4mk4A-3e7wA:3.3 | 4mk4A-3e7wA:19.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3el6 | ERYTHROMYCINDEHYDRATASE (Saccharopolysporaerythraea) |
PF14765(PS-DH) | 4 | PRO A 53SER A 55VAL A 56VAL A 45 | None | 0.75A | 4mk4A-3el6A:undetectable | 4mk4A-3el6A:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fve | DIAMINOPIMELATEEPIMERASE (Mycobacteriumtuberculosis) |
PF01678(DAP_epimerase) | 4 | ARG A 141VAL A 257VAL A 261GLY A 246 | None | 1.00A | 4mk4A-3fveA:undetectable | 4mk4A-3fveA:21.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gcw | PROPROTEINCONVERTASESUBTILISIN/KEXINTYPE 9 (Homo sapiens) |
PF00082(Peptidase_S8) | 4 | MET A 398VAL A 284VAL A 233GLY A 232 | None | 1.01A | 4mk4A-3gcwA:2.4 | 4mk4A-3gcwA:19.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gju | PUTATIVEAMINOTRANSFERASE (Mesorhizobiumjaponicum) |
PF00202(Aminotran_3) | 4 | ARG A 34SER A 454VAL A 455GLY A 416 | None | 0.87A | 4mk4A-3gjuA:undetectable | 4mk4A-3gjuA:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h77 | PQS BIOSYNTHETICENZYME (Pseudomonasaeruginosa) |
PF08541(ACP_syn_III_C)PF08545(ACP_syn_III) | 4 | MET A 55PRO A 294VAL A 295GLY A 118 | None | 0.85A | 4mk4A-3h77A:2.4 | 4mk4A-3h77A:23.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i4j | AMINOTRANSFERASE,CLASS III (Deinococcusradiodurans) |
PF00202(Aminotran_3) | 4 | PRO A 406SER A 408VAL A 40GLY A 262 | None | 1.03A | 4mk4A-3i4jA:undetectable | 4mk4A-3i4jA:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ics | COENZYME A-DISULFIDEREDUCTASE (Bacillusanthracis) |
PF00581(Rhodanese)PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 4 | PRO A 438SER A 434VAL A 401GLY A 400 | None | 1.01A | 4mk4A-3icsA:3.4 | 4mk4A-3icsA:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l0z | PUTATIVENICOTINATE-NUCLEOTIDE-DIMETHYLBENZIMIDAZOLEPHOSPHORIBOSYLTRANSFERASE (Methanocaldococcusjannaschii) |
PF02277(DBI_PRT) | 4 | PRO A 153SER A 38VAL A 317GLY A 316 | PO4 A 351 (-4.7A)PO4 A 351 (-2.9A)NoneNone | 0.98A | 4mk4A-3l0zA:2.4 | 4mk4A-3l0zA:20.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lhe | GNTR FAMILYTRANSCRIPTIONALREGULATOR (Bacillusanthracis) |
PF07702(UTRA) | 4 | PRO A 148SER A 150VAL A 151GLY A 109 | CL A 233 ( 4.7A) CL A 233 (-3.2A)NoneNone | 0.92A | 4mk4A-3lheA:undetectable | 4mk4A-3lheA:16.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ljp | CHOLINE OXIDASE (Arthrobacterglobiformis) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 4 | SER A 501VAL A 471VAL A 19GLY A 20 | NoneNoneNoneFDA A 547 (-3.2A) | 0.76A | 4mk4A-3ljpA:undetectable | 4mk4A-3ljpA:21.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3llc | PUTATIVE HYDROLASE (Agrobacteriumvitis) |
PF12697(Abhydrolase_6) | 4 | ARG A 250VAL A 140VAL A 241GLY A 213 | None | 0.92A | 4mk4A-3llcA:4.6 | 4mk4A-3llcA:23.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lrv | PRE-MRNA-SPLICINGFACTOR 19 (Saccharomycescerevisiae) |
no annotation | 4 | PRO A 196VAL A 210VAL A 337GLY A 336 | None | 0.93A | 4mk4A-3lrvA:undetectable | 4mk4A-3lrvA:22.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m07 | PUTATIVE ALPHAAMYLASE (Salmonellaenterica) |
PF00128(Alpha-amylase)PF11941(DUF3459) | 4 | ARG A 540PRO A 382VAL A 383GLY A 525 | None | 1.02A | 4mk4A-3m07A:undetectable | 4mk4A-3m07A:20.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m49 | TRANSKETOLASE (Bacillusanthracis) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 4 | MET A 589VAL A 603VAL A 626GLY A 627 | NoneFMT A 715 (-4.9A)NoneNone | 0.99A | 4mk4A-3m49A:undetectable | 4mk4A-3m49A:19.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mdn | GLUTAMINEAMINOTRANSFERASECLASS-II DOMAINPROTEIN (Ruegeriapomeroyi) |
PF13230(GATase_4) | 4 | SER A 224VAL A 223VAL A 46GLY A 45 | None | 0.98A | 4mk4A-3mdnA:undetectable | 4mk4A-3mdnA:20.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mfd | D-ALANYL-D-ALANINECARBOXYPEPTIDASEDACB (Bacillussubtilis) |
PF00768(Peptidase_S11)PF07943(PBP5_C) | 4 | SER A 83VAL A 82VAL A 127GLY A 128 | None | 0.74A | 4mk4A-3mfdA:undetectable | 4mk4A-3mfdA:21.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nv0 | NUCLEAR RNA EXPORTFACTOR 2NTF2-RELATED EXPORTPROTEIN (Caenorhabditiselegans;Caenorhabditiselegans) |
no annotationPF02136(NTF2) | 4 | PRO B 84SER A 377VAL A 376GLY B 93 | NoneNoneNone NA B 455 (-3.5A) | 0.99A | 4mk4A-3nv0B:undetectable | 4mk4A-3nv0B:17.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nv0 | NUCLEAR RNA EXPORTFACTOR 2NTF2-RELATED EXPORTPROTEIN (Caenorhabditiselegans;Caenorhabditiselegans) |
no annotationPF02136(NTF2) | 4 | PRO B 84SER A 377VAL A 376GLY B 94 | None | 0.77A | 4mk4A-3nv0B:undetectable | 4mk4A-3nv0B:17.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o12 | UNCHARACTERIZEDPROTEIN YJL217W (Saccharomycescerevisiae) |
PF07081(DUF1349) | 4 | ARG A 84PRO A 18VAL A 21GLY A 51 | None | 0.94A | 4mk4A-3o12A:undetectable | 4mk4A-3o12A:24.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oa2 | WBPB (Pseudomonasaeruginosa) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 4 | ARG A 225PRO A 236SER A 238VAL A 239 | None | 0.97A | 4mk4A-3oa2A:2.3 | 4mk4A-3oa2A:21.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oec | CARVEOLDEHYDROGENASE(MYTHA.01326.C,A0R518 HOMOLOG) (Mycolicibacteriumthermoresistibile) |
PF13561(adh_short_C2) | 4 | PRO A 216VAL A 265VAL A 175GLY A 176 | None | 0.64A | 4mk4A-3oecA:3.0 | 4mk4A-3oecA:21.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pe7 | OLIGOGALACTURONATELYASE (Yersiniaenterocolitica) |
PF14583(Pectate_lyase22) | 4 | PRO A 383SER A 385VAL A 386GLY A 20 | None | 0.73A | 4mk4A-3pe7A:undetectable | 4mk4A-3pe7A:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qvl | PUTATIVE HYDANTOINRACEMASE (Klebsiellapneumoniae) |
PF01177(Asp_Glu_race) | 4 | PRO A 83SER A 79VAL A 58GLY A 59 | None5HY A 1 (-3.1A)NoneNone | 0.95A | 4mk4A-3qvlA:3.7 | 4mk4A-3qvlA:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r31 | BETAINE ALDEHYDEDEHYDROGENASE (Agrobacteriumfabrum) |
PF00171(Aldedh) | 4 | MET A 319PRO A 364VAL A 367GLY A 361 | None | 1.00A | 4mk4A-3r31A:2.2 | 4mk4A-3r31A:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rbl | AROMATIC L-AMINOACID DECARBOXYLASE (Homo sapiens) |
PF00282(Pyridoxal_deC) | 4 | ARG A 285VAL A 240VAL A 291GLY A 290 | None | 1.00A | 4mk4A-3rblA:4.2 | 4mk4A-3rblA:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sjn | MANDELATERACEMASE/MUCONATELACTONIZING PROTEIN (Shewanellapealeana) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | SER A 312VAL A 313VAL A 41GLY A 42 | None | 0.99A | 4mk4A-3sjnA:undetectable | 4mk4A-3sjnA:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sql | GLYCOSYL HYDROLASEFAMILY 3 (Synechococcussp. PCC 7002) |
PF00933(Glyco_hydro_3) | 4 | ARG A 217VAL A 237VAL A 150GLY A 198 | None | 0.99A | 4mk4A-3sqlA:3.6 | 4mk4A-3sqlA:20.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ulk | KETOL-ACIDREDUCTOISOMERASE (Escherichiacoli) |
PF01450(IlvC)PF07991(IlvN) | 4 | PRO A 154SER A 131VAL A 152GLY A 158 | PRO A 154 (-1.1A)SER A 131 (-0.0A)VAL A 152 ( 0.6A)GLY A 158 ( 0.0A) | 0.96A | 4mk4A-3ulkA:2.9 | 4mk4A-3ulkA:21.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3us8 | ISOCITRATEDEHYDROGENASE [NADP] (Sinorhizobiummeliloti) |
PF00180(Iso_dh) | 4 | PRO A 95ARG A 100VAL A 46GLY A 45 | SO4 A 501 ( 4.7A)SO4 A 501 ( 4.8A)NoneNone | 0.65A | 4mk4A-3us8A:4.1 | 4mk4A-3us8A:20.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vly | NITRITE REDUCTASE (Nicotianatabacum) |
PF01077(NIR_SIR)PF03460(NIR_SIR_ferr) | 4 | PRO A 227VAL A 178VAL A 229GLY A 183 | None | 0.90A | 4mk4A-3vlyA:2.0 | 4mk4A-3vlyA:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wgk | CELL DIVISIONPROTEIN FTSZ (Staphylococcusaureus) |
PF00091(Tubulin)PF12327(FtsZ_C) | 4 | MET A 224ARG A 191VAL A 280VAL A 305 | None | 1.03A | 4mk4A-3wgkA:4.1 | 4mk4A-3wgkA:20.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zif | PENTON PROTEIN (BovinemastadenovirusB) |
PF01686(Adeno_Penton_B) | 4 | PRO M 383SER M 426VAL M 345GLY M 344 | None | 0.84A | 4mk4A-3zifM:undetectable | 4mk4A-3zifM:22.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zx1 | OXIDOREDUCTASE,PUTATIVE (Campylobacterjejuni) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 4 | MET A 217VAL A 246VAL A 191GLY A 194 | None | 0.90A | 4mk4A-3zx1A:undetectable | 4mk4A-3zx1A:20.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a0s | OCTENOYL-COAREDUCTASE/CARBOXYLASE (Streptomycescinnabarigriseus) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 4 | PRO A 382SER A 199VAL A 198GLY A 378 | None | 0.98A | 4mk4A-4a0sA:undetectable | 4mk4A-4a0sA:21.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4atw | ALPHA-L-ARABINOFURANOSIDASE DOMAINPROTEIN (Thermotogamaritima) |
PF06964(Alpha-L-AF_C) | 4 | PRO A 320SER A 17VAL A 275GLY A 274 | None | 0.97A | 4mk4A-4atwA:undetectable | 4mk4A-4atwA:22.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ci0 | F420-REDUCINGHYDROGENASE, SUBUNITALPHAF420-REDUCINGHYDROGENASE, SUBUNITBETA (Methanothermobactermarburgensis;Methanothermobactermarburgensis) |
PF00374(NiFeSe_Hases)PF04422(FrhB_FdhB_N)PF04432(FrhB_FdhB_C) | 4 | SER A 152ARG A 155VAL C 119GLY C 118 | None | 0.97A | 4mk4A-4ci0A:undetectable | 4mk4A-4ci0A:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ci6 | PROTEIN KINASE YOPO (Yersiniaenterocolitica) |
PF00069(Pkinase)PF09632(Rac1) | 4 | PRO B 297SER B 291VAL B 311GLY B 312 | None | 1.03A | 4mk4A-4ci6B:undetectable | 4mk4A-4ci6B:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cql | ESTRADIOL17-BETA-DEHYDROGENASE 8 (Homo sapiens) |
PF13561(adh_short_C2) | 4 | PRO A 199VAL A 233VAL A 158GLY A 159 | None | 0.82A | 4mk4A-4cqlA:3.7 | 4mk4A-4cqlA:23.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cqm | CARBONYL REDUCTASEFAMILY MEMBER 4 (Homo sapiens) |
PF13561(adh_short_C2) | 4 | PRO B 178VAL B 209VAL B 137GLY B 138 | NAP B 301 (-4.5A)NoneNoneNone | 0.72A | 4mk4A-4cqmB:3.8 | 4mk4A-4cqmB:19.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4doo | CHALCONE-FLAVANONEISOMERASE FAMILYPROTEIN (Arabidopsisthaliana) |
PF16035(Chalcone_2) | 4 | VAL A 94ARG A 142VAL A 27GLY A 46 | None | 1.01A | 4mk4A-4dooA:undetectable | 4mk4A-4dooA:18.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gqb | PROTEIN ARGININEN-METHYLTRANSFERASE5 (Homo sapiens) |
PF05185(PRMT5)PF17285(PRMT5_TIM)PF17286(PRMT5_C) | 4 | PRO A 620VAL A 621VAL A 542GLY A 595 | None | 1.02A | 4mk4A-4gqbA:undetectable | 4mk4A-4gqbA:20.28 |