SIMILAR PATTERNS OF AMINO ACIDS FOR 4MK4_A_CHDA503

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j7x INTERPHOTORECEPTOR
RETINOID-BINDING
PROTEIN

(Xenopus laevis) 		PF03572
(Peptidase_S41)
PF11918
(Peptidase_S41_N) 		5 LEU A  30
LEU A  33
LEU A  51
ILE A  26
VAL A 259
 None
 1.41A 4mk4A-1j7xA:
1.0		 4mk4A-1j7xA:
21.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae) 		PF00762
(Ferrochelatase) 		5 LEU A  59
LEU A  62
ARG A  87
VAL A 277
TRP A 282
 None
 1.05A 4mk4A-1lbqA:
48.3		 4mk4A-1lbqA:
49.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae) 		PF00762
(Ferrochelatase) 		8 LEU A  59
LEU A  62
LYS A  90
ILE A  91
THR A 170
HIS A 235
VAL A 277
TRP A 282
 None
 0.78A 4mk4A-1lbqA:
48.3		 4mk4A-1lbqA:
49.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae) 		PF00762
(Ferrochelatase) 		5 LEU A  68
LYS A  90
THR A 170
HIS A 235
VAL A 277
 None
 1.18A 4mk4A-1lbqA:
48.3		 4mk4A-1lbqA:
49.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q15 CARA

(Pectobacterium
carotovorum) 		PF00733
(Asn_synthase)
PF09147
(DUF1933) 		5 LEU A  92
LEU A  88
LEU A  84
ARG A  91
THR A  63
 None
 1.10A 4mk4A-1q15A:
2.2		 4mk4A-1q15A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhg ATP-DEPENDENT
HELICASE PCRA

(Geobacillus
stearothermophilus) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		5 LEU A 617
LEU A 577
LEU A 564
ILE A 321
VAL A 299
 None
 1.31A 4mk4A-1qhgA:
3.6		 4mk4A-1qhgA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ux8 YJBI PROTEIN

(Bacillus
subtilis) 		PF01152
(Bac_globin) 		5 LEU A 110
LEU A  53
ARG A 113
THR A  45
HIS A  76
 None
HEM  A 700 (-4.9A)
None
HEM  A 700 (-3.1A)
HEM  A 700 (-3.1A)
 1.41A 4mk4A-1ux8A:
undetectable		 4mk4A-1ux8A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v87 DELTEX PROTEIN 2

(Mus musculus) 		PF00097
(zf-C3HC4) 		5 LEU A  67
LEU A  70
LEU A  83
ARG A  14
THR A  90
 None
 1.35A 4mk4A-1v87A:
undetectable		 4mk4A-1v87A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yxo 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 1

(Pseudomonas
aeruginosa) 		PF04166
(PdxA) 		5 LEU A1048
LEU A1022
LEU A1023
ARG A1044
HIS A1296
 None
 0.97A 4mk4A-1yxoA:
3.6		 4mk4A-1yxoA:
25.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6r MLC PROTEIN

(Escherichia
coli) 		PF00480
(ROK) 		5 LEU A  99
LEU A  88
LEU A 146
ILE A  97
HIS A 185
 None
 1.36A 4mk4A-1z6rA:
3.1		 4mk4A-1z6rA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbr CONSERVED
HYPOTHETICAL PROTEIN

(Porphyromonas
gingivalis) 		PF04371
(PAD_porph) 		5 LEU A 281
LEU A 328
LEU A 321
ILE A 283
TRP A  20
 None
 1.20A 4mk4A-1zbrA:
0.6		 4mk4A-1zbrA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2avt DNA POLYMERASE III
BETA SUBUNIT

(Streptococcus
pyogenes) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		5 LEU A  15
LEU A  45
ILE A  86
THR A  39
VAL A 104
 None
 1.41A 4mk4A-2avtA:
undetectable		 4mk4A-2avtA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E

(Methanothermobacter
thermautotrophicus) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N)
PF02938
(GAD) 		5 LEU C 106
LEU C 154
ILE C 204
THR C 133
VAL C 213
 None
 1.23A 4mk4A-2d6fC:
undetectable		 4mk4A-2d6fC:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkk CYTOCHROME P450

(Streptomyces
coelicolor) 		PF00067
(p450) 		5 LEU A 266
LEU A 260
LEU A 257
ILE A 337
TRP A 391
 None
 1.25A 4mk4A-2dkkA:
undetectable		 4mk4A-2dkkA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkk CYTOCHROME P450

(Streptomyces
coelicolor) 		PF00067
(p450) 		5 LEU A 377
LEU A 373
LEU A 369
ARG A 376
THR A 250
 None
 1.29A 4mk4A-2dkkA:
undetectable		 4mk4A-2dkkA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Escherichia
coli) 		PF01019
(G_glu_transpept) 		5 LEU A 383
ARG A 379
ILE A 378
THR A 355
HIS A 299
 None
 1.00A 4mk4A-2e0xA:
undetectable		 4mk4A-2e0xA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e8b PROBABLE
MOLYBDOPTERIN-GUANIN
E DINUCLEOTIDE
BIOSYNTHESIS PROTEIN
A

(Aquifex
aeolicus) 		PF12804
(NTP_transf_3) 		5 LEU A 163
LEU A 164
LEU A 134
ILE A 149
VAL A 102
 None
 1.30A 4mk4A-2e8bA:
2.3		 4mk4A-2e8bA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ec5 DERMONECROTIC TOXIN

(Pasteurella
multocida) 		PF11647
(MLD) 		5 LEU A 664
LEU A 668
LEU A 695
LYS A 617
ILE A 621
 None
 1.29A 4mk4A-2ec5A:
undetectable		 4mk4A-2ec5A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2juo GA-BINDING PROTEIN
ALPHA CHAIN

(Mus musculus) 		PF11620
(GABP-alpha) 		5 LEU A  51
LEU A 111
ILE A  42
VAL A  86
TRP A 122
 None
 1.38A 4mk4A-2juoA:
undetectable		 4mk4A-2juoA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nz9 BOTULINUM NEUROTOXIN
TYPE A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		5 LEU A 656
LEU A 664
LEU A 665
ILE A 630
THR A 723
 None
 1.42A 4mk4A-2nz9A:
undetectable		 4mk4A-2nz9A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okx RHAMNOSIDASE B

(Bacillus sp.
GL1) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		5 LEU A 661
LEU A 702
LEU A 732
ILE A 634
THR A 696
 None
 1.39A 4mk4A-2okxA:
undetectable		 4mk4A-2okxA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2opj O-SUCCINYLBENZOATE-C
OA SYNTHASE

(Thermobifida
fusca) 		PF13378
(MR_MLE_C) 		5 LEU A 261
LEU A 258
LEU A 270
ARG A  22
ILE A  10
 None
 1.31A 4mk4A-2opjA:
1.7		 4mk4A-2opjA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppv UNCHARACTERIZED
PROTEIN

(Staphylococcus
epidermidis) 		PF01933
(UPF0052) 		5 LEU A 307
LEU A  18
LEU A  15
ILE A 249
THR A  30
 None
 1.23A 4mk4A-2ppvA:
2.1		 4mk4A-2ppvA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		5 LEU A 190
LEU A 191
LEU A 138
ILE A 118
TRP A  46
 None
 1.37A 4mk4A-2q3yA:
undetectable		 4mk4A-2q3yA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkd ZINC FINGER PROTEIN
ZPR1

(Mus musculus) 		PF03367
(zf-ZPR1) 		5 LEU A 357
LEU A 354
LEU A 313
ILE A 361
THR A 316
 None
 1.40A 4mk4A-2qkdA:
undetectable		 4mk4A-2qkdA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE

(Bacillus
subtilis) 		PF01979
(Amidohydro_1) 		5 LEU A 131
LEU A  96
ILE A 353
THR A 176
HIS A 220
 None
 1.10A 4mk4A-2vhlA:
undetectable		 4mk4A-2vhlA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vmx SERINE
HYDROXYMETHYLTRANSFE
RASE

(Geobacillus
stearothermophilus) 		PF00464
(SHMT) 		5 LEU A 296
LEU A 313
LEU A 312
ILE A 380
VAL A 363
 None
 1.28A 4mk4A-2vmxA:
2.5		 4mk4A-2vmxA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE

(Escherichia
coli) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 LEU A 242
LEU A 161
LEU A 258
ILE A 154
VAL A 271
 None
 1.37A 4mk4A-2xf8A:
4.2		 4mk4A-2xf8A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zvw PROLIFERATING CELL
NUCLEAR ANTIGEN 2

(Arabidopsis
thaliana) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		5 LEU A  79
LEU A  16
LEU A  72
ILE A  88
VAL A  99
 None
 1.16A 4mk4A-2zvwA:
undetectable		 4mk4A-2zvwA:
20.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		8 LEU A  89
LEU A  92
LEU A  98
ILE A 119
THR A 198
HIS A 263
VAL A 305
TRP A 310
 None
CHD  A   1 (-4.8A)
CHD  A   1 (-4.3A)
None
None
CHD  A   1 (-4.3A)
CHD  A   1 ( 4.9A)
CHD  A   2 (-4.7A)
 0.54A 4mk4A-3aqiA:
59.3		 4mk4A-3aqiA:
99.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		7 LEU A  89
LEU A  92
LEU A  98
LYS A 118
ILE A 119
VAL A 305
TRP A 310
 None
CHD  A   1 (-4.8A)
CHD  A   1 (-4.3A)
None
None
CHD  A   1 ( 4.9A)
CHD  A   2 (-4.7A)
 1.10A 4mk4A-3aqiA:
59.3		 4mk4A-3aqiA:
99.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmy PAIRED BOX PROTEIN
PAX-3

(Homo sapiens) 		PF00046
(Homeobox) 		5 LEU A  34
LEU A  16
LEU A  13
ARG A  37
THR A   7
 None
 1.42A 4mk4A-3cmyA:
undetectable		 4mk4A-3cmyA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1r FRUCTOSE-1,6-BISPHOS
PHATASE CLASS II
GLPX

(Escherichia
coli) 		PF03320
(FBPase_glpX) 		5 LEU A   5
LEU A 307
ARG A   2
ILE A  49
THR A 283
 None
 1.35A 4mk4A-3d1rA:
undetectable		 4mk4A-3d1rA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egl DEGV FAMILY PROTEIN

(Corynebacterium
glutamicum) 		PF02645
(DegV) 		5 LEU A 221
LEU A 192
LEU A 195
ILE A 209
VAL A 205
 None
MLY  A 191 ( 4.5A)
MLY  A 191 ( 3.7A)
None
None
 1.19A 4mk4A-3eglA:
undetectable		 4mk4A-3eglA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		5 LEU A 776
LEU A 786
ILE A 895
VAL A 902
TRP A 907
 None
 1.35A 4mk4A-3fg4A:
undetectable		 4mk4A-3fg4A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fz0 NUCLEOSIDE
HYDROLASE, PUTATIVE

(Trypanosoma
brucei) 		PF01156
(IU_nuc_hydro) 		5 LEU A  22
LEU A 349
LEU A 346
THR A 214
VAL A 340
 None
 1.38A 4mk4A-3fz0A:
2.9		 4mk4A-3fz0A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gge PDZ
DOMAIN-CONTAINING
PROTEIN GIPC2

(Homo sapiens) 		PF00595
(PDZ) 		5 LEU A 129
LEU A 182
LEU A 185
ILE A 141
VAL A 118
 None
 1.15A 4mk4A-3ggeA:
undetectable		 4mk4A-3ggeA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyc PUTATIVE GLYCOSIDE
HYDROLASE

(Parabacteroides
distasonis) 		PF12876
(Cellulase-like) 		5 LEU A 126
LEU A 122
LEU A  53
ILE A 179
TRP A 141
 None
 1.39A 4mk4A-3gycA:
undetectable		 4mk4A-3gycA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hgq HDA1 COMPLEX SUBUNIT
3

(Saccharomyces
cerevisiae) 		PF11496
(HDA2-3) 		5 LEU A 119
LEU A 122
LEU A 125
ILE A 135
VAL A 155
 None
 1.26A 4mk4A-3hgqA:
undetectable		 4mk4A-3hgqA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6y CATENIN DELTA-1

(Homo sapiens) 		PF00514
(Arm) 		5 LEU A 479
LEU A 476
LEU A 460
ILE A 485
THR A 498
 None
 1.35A 4mk4A-3l6yA:
undetectable		 4mk4A-3l6yA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lws AROMATIC AMINO ACID
BETA-ELIMINATING
LYASE/THREONINE
ALDOLASE

(Exiguobacterium
sibiricum) 		PF01212
(Beta_elim_lyase) 		5 LEU A 140
LEU A 142
LEU A 178
ILE A 160
THR A 188
 None
 1.33A 4mk4A-3lwsA:
undetectable		 4mk4A-3lwsA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nfi DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA49

(Saccharomyces
cerevisiae) 		PF06870
(RNA_pol_I_A49) 		5 LEU A 265
LEU A 262
LEU A 259
ILE A 336
THR A 251
 None
 1.27A 4mk4A-3nfiA:
undetectable		 4mk4A-3nfiA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o53 PROTEIN LRIM1

(Anopheles
gambiae) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 LEU A 171
LEU A 193
ILE A 154
THR A 217
VAL A 181
 None
 1.35A 4mk4A-3o53A:
undetectable		 4mk4A-3o53A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3okz PUTATIVE
UNCHARACTERIZED
PROTEIN GBS0355

(Streptococcus
agalactiae) 		PF03816
(LytR_cpsA_psr) 		5 LEU A  87
LEU A 102
LEU A 125
LYS A 315
ILE A 314
 None
 1.32A 4mk4A-3okzA:
undetectable		 4mk4A-3okzA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p0f URIDINE
PHOSPHORYLASE 2

(Homo sapiens) 		PF01048
(PNP_UDP_1) 		5 LEU A 128
LEU A 131
LEU A  52
ILE A 112
THR A  49
 None
 1.38A 4mk4A-3p0fA:
4.7		 4mk4A-3p0fA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rg1 CD180 MOLECULE

(Bos taurus) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 LEU A 503
LEU A 525
LEU A 546
ILE A 486
HIS A 542
 None
 1.29A 4mk4A-3rg1A:
undetectable		 4mk4A-3rg1A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rj9 ALCOHOL
DEHYDROGENASE

(Scaptodrosophila
lebanonensis) 		PF00106
(adh_short) 		5 LEU A   3
LEU A  30
ARG A  28
ILE A 225
THR A  58
 None
 1.34A 4mk4A-3rj9A:
3.5		 4mk4A-3rj9A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s2j DIPEPTIDASE

(Streptomyces
coelicolor) 		PF01244
(Peptidase_M19) 		5 LEU A 357
LEU A 354
LEU A 345
ILE A 317
VAL A 296
 None
 1.16A 4mk4A-3s2jA:
undetectable		 4mk4A-3s2jA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqz PUTATIVE
HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Streptococcus
mutans) 		PF00195
(Chal_sti_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 LEU A 290
LEU A 287
LEU A 284
ILE A 168
THR A  11
 None
None
None
None
GOL  A 392 (-4.2A)
 1.27A 4mk4A-3sqzA:
undetectable		 4mk4A-3sqzA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqs RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Coxiella
burnetii) 		PF00398
(RrnaAD) 		5 LEU A 115
LEU A 116
LEU A 153
ILE A  39
THR A 142
 None
 1.27A 4mk4A-3tqsA:
3.6		 4mk4A-3tqsA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txv PROBABLE TAGATOSE
6-PHOSPHATE KINASE

(Sinorhizobium
meliloti) 		PF08013
(Tagatose_6_P_K) 		5 LEU A 410
LEU A 303
LEU A 373
ILE A 387
THR A 318
 None
 1.27A 4mk4A-3txvA:
undetectable		 4mk4A-3txvA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdg URACIL-DNA
GLYCOSYLASE

(Staphylococcus
aureus) 		PF03167
(UDG) 		5 LEU A 115
LEU A  56
LEU A 156
ILE A 141
VAL A 152
 None
 1.42A 4mk4A-3wdgA:
undetectable		 4mk4A-3wdgA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zoq URACIL-DNA
GLYCOSYLASE

(Bacillus
subtilis) 		PF03167
(UDG) 		5 LEU A 122
LEU A  62
LEU A 163
ILE A 148
VAL A 159
 None
 1.33A 4mk4A-3zoqA:
undetectable		 4mk4A-3zoqA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyo LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B

(Mus musculus) 		PF00560
(LRR_1)
PF07679
(I-set)
PF13855
(LRR_8) 		5 LEU A 143
LEU A 167
LEU A 191
ILE A 127
VAL A 183
 None
 1.39A 4mk4A-3zyoA:
undetectable		 4mk4A-3zyoA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwp PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN-3

(Drosophila
melanogaster) 		no annotation 5 LEU A 599
LEU A 596
LEU A 593
ILE A 554
THR A 648
 None
 1.01A 4mk4A-4bwpA:
undetectable		 4mk4A-4bwpA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 709
LEU A 713
LEU A 839
ILE A 780
THR A 737
 None
 1.29A 4mk4A-4ckrA:
undetectable		 4mk4A-4ckrA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e04 BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB1

(Rhodopseudomonas
palustris) 		PF01590
(GAF)
PF08446
(PAS_2) 		5 LEU A  59
LEU A  48
LEU A  51
ILE A  41
VAL A  93
 None
 1.23A 4mk4A-4e04A:
undetectable		 4mk4A-4e04A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fc8 TRANSCRIPTION
PROTEIN RTR1

(Kluyveromyces
lactis) 		PF04181
(RPAP2_Rtr1) 		5 LEU A  33
LEU A  55
LEU A 126
LYS A   8
ILE A   7
 None
 0.99A 4mk4A-4fc8A:
undetectable		 4mk4A-4fc8A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fs7 UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF13306
(LRR_5) 		5 LEU A 298
LEU A 319
LEU A 342
ILE A 278
VAL A 308
 None
 1.15A 4mk4A-4fs7A:
undetectable		 4mk4A-4fs7A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxr MALONYL COA
SYNTHETASE,
BENZOATE-COA LIGASE
CHIMERIC PROTEIN

(Rhodopseudomonas
palustris;
Paraburkholderia
xenovorans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 LEU A 256
LEU A 280
ARG A 255
LYS A 231
HIS A 209
 None
None
GOL  A 606 (-3.7A)
MLY  A 230 (-3.1A)
CO3  A 608 (-3.7A)
 1.19A 4mk4A-4gxrA:
4.2		 4mk4A-4gxrA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxr MALONYL COA
SYNTHETASE,
BENZOATE-COA LIGASE
CHIMERIC PROTEIN

(Rhodopseudomonas
palustris;
Paraburkholderia
xenovorans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 LEU A 256
LEU A 280
LYS A 231
ILE A 236
HIS A 209
 None
None
MLY  A 230 (-3.1A)
MLY  A 235 ( 4.3A)
CO3  A 608 (-3.7A)
 1.22A 4mk4A-4gxrA:
4.2		 4mk4A-4gxrA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzc CYSE, SERINE
ACETYLTRANSFERASE

(Brucella
abortus) 		PF00132
(Hexapep)
PF06426
(SATase_N) 		5 LEU A  51
LEU A  91
ILE A  23
THR A 123
VAL A  98
 None
 1.26A 4mk4A-4hzcA:
undetectable		 4mk4A-4hzcA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3q CATECHOL OXIDASE

(Aspergillus
oryzae) 		PF00264
(Tyrosinase) 		5 LEU A 190
LEU A 180
LEU A 182
ILE A 245
HIS A 284
 None
None
None
None
CU  A1002 (-3.2A)
 1.31A 4mk4A-4j3qA:
undetectable		 4mk4A-4j3qA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k17 LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A

(Mus musculus) 		PF13516
(LRR_6) 		5 LEU A 555
LEU A 520
LEU A 498
ILE A 567
THR A 504
 None
 1.38A 4mk4A-4k17A:
undetectable		 4mk4A-4k17A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l3a INTERNALIN K

(Listeria
monocytogenes) 		no annotation 5 LEU A 152
LEU A 128
LEU A 106
ILE A 167
VAL A 135
 None
 1.42A 4mk4A-4l3aA:
undetectable		 4mk4A-4l3aA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata) 		PF01580
(FtsK_SpoIIIE) 		5 LEU A 431
LEU A 751
LEU A 524
ILE A 425
VAL A 691
 None
 1.18A 4mk4A-4nh0A:
2.6		 4mk4A-4nh0A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pbc D-AMINO ACID
AMINOTRANSFERASE

(Burkholderia
cenocepacia) 		PF01063
(Aminotran_4) 		5 LEU A  71
LEU A  74
LEU A  78
ILE A  96
THR A 119
 None
 1.35A 4mk4A-4pbcA:
undetectable		 4mk4A-4pbcA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pts GLUTATHIONE
S-TRANSFERASE

(Gordonia
bronchialis) 		PF13409
(GST_N_2)
PF13410
(GST_C_2) 		5 LEU A 212
LEU A 262
LEU A 256
ILE A 178
VAL A 186
 None
 1.35A 4mk4A-4ptsA:
undetectable		 4mk4A-4ptsA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxq D-GLUCURONYL C5
EPIMERASE B

(Danio rerio) 		PF06662
(C5-epim_C) 		5 LEU A 513
LEU A 517
ILE A 481
THR A 522
HIS A 547
 None
 1.17A 4mk4A-4pxqA:
undetectable		 4mk4A-4pxqA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qo5 HYPOTHETICAL
MULTIHEME PROTEIN

(Ignicoccus
hospitalis) 		PF13435
(Cytochrome_C554)
PF13447
(Multi-haem_cyto) 		5 LEU A 391
LEU A 397
ILE A 166
THR A 465
VAL A 480
 None
 1.20A 4mk4A-4qo5A:
undetectable		 4mk4A-4qo5A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6f LEUCINE RICH REPEAT
DLRR_I

(synthetic
construct) 		PF12354
(Internalin_N)
PF13855
(LRR_8) 		5 LEU A 163
LEU A 161
ILE A 147
THR A 156
VAL A 127
 None
 1.19A 4mk4A-4r6fA:
undetectable		 4mk4A-4r6fA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r90 ANTI CD70 LLAMA
GLAMA FAB 27B3 HEAVY
CHAIN

(Lama glama) 		PF07654
(C1-set)
PF07686
(V-set) 		5 LEU H 179
LEU H 187
ILE H 119
THR H 160
HIS H 209
 None
 1.12A 4mk4A-4r90H:
undetectable		 4mk4A-4r90H:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x3m RNA 2'-O RIBOSE
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF00588
(SpoU_methylase) 		5 LEU A  70
LEU A  51
LEU A  30
ILE A   3
THR A  82
 None
 1.39A 4mk4A-4x3mA:
undetectable		 4mk4A-4x3mA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xup ENDO-1,4-BETA-XYLANA
SE C

(Paenibacillus
barcinonensis) 		PF02018
(CBM_4_9) 		5 LEU A 225
LEU A 228
LEU A 173
ILE A 297
THR A 332
 None
 1.41A 4mk4A-4xupA:
undetectable		 4mk4A-4xupA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ylg ADP-RIBOSYLATION
FACTOR

(Entamoeba
histolytica) 		PF00025
(Arf) 		5 LEU A 162
LEU A 166
LEU A   8
ILE A  29
VAL A  52
 None
 1.09A 4mk4A-4ylgA:
2.6		 4mk4A-4ylgA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ady GTPASE HFLX

(Escherichia
coli) 		PF01926
(MMR_HSR1)
PF13167
(GTP-bdg_N)
PF16360
(GTP-bdg_M) 		5 LEU 6 357
LEU 6 353
LEU 6 342
ARG 6 360
THR 6 212
 None
None
None
None
GNP  6 527 (-3.2A)
 1.36A 4mk4A-5ady6:
3.7		 4mk4A-5ady6:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aor DOSAGE COMPENSATION
REGULATOR

(Drosophila
melanogaster) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF04408
(HA2)
PF07717
(OB_NTP_bind) 		5 LEU A 643
LEU A 639
LEU A 630
ILE A 733
TRP A 756
 None
 1.41A 4mk4A-5aorA:
2.6		 4mk4A-5aorA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csa ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00364
(Biotin_lipoyl)
PF08326
(ACC_central) 		5 LEU A 833
LEU A 838
ILE A 925
THR A 796
HIS A 846
 None
 1.36A 4mk4A-5csaA:
undetectable		 4mk4A-5csaA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h1c DNA REPAIR PROTEIN
RAD51 HOMOLOG 1

(Homo sapiens) 		PF08423
(Rad51)
PF14520
(HHH_5) 		5 LEU A 255
LEU A 252
LEU A 249
ARG A 254
HIS A 244
 None
 1.10A 4mk4A-5h1cA:
undetectable		 4mk4A-5h1cA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h1c DNA REPAIR PROTEIN
RAD51 HOMOLOG 1

(Homo sapiens) 		PF08423
(Rad51)
PF14520
(HHH_5) 		5 LEU A 255
LEU A 252
LEU A 249
ARG A 254
THR A 225
 None
 1.40A 4mk4A-5h1cA:
undetectable		 4mk4A-5h1cA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5m ALPHA-CATENIN-LIKE
PROTEIN HMP-1

(Caenorhabditis
elegans) 		PF01044
(Vinculin) 		5 LEU A 496
LEU A 492
LEU A 451
ILE A 384
HIS A 420
 None
 1.32A 4mk4A-5h5mA:
undetectable		 4mk4A-5h5mA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hiu GTPASE
ACTIVATOR-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF11864
(DUF3384) 		5 LEU A 432
LEU A 428
LEU A 383
ILE A 443
VAL A 353
 LEU  A 432 ( 0.6A)
LEU  A 428 ( 0.5A)
LEU  A 383 ( 0.5A)
ILE  A 443 ( 0.7A)
VAL  A 353 ( 0.6A)
 1.19A 4mk4A-5hiuA:
undetectable		 4mk4A-5hiuA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jb3 30S RIBOSOMAL
PROTEIN S3

(Pyrococcus
abyssi) 		PF00189
(Ribosomal_S3_C)
PF07650
(KH_2) 		5 LEU Z  99
LEU Z 103
LEU Z 171
ILE Z 130
THR Z 137
 None
 1.30A 4mk4A-5jb3Z:
undetectable		 4mk4A-5jb3Z:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lfn CHONDROADHERIN

(Homo sapiens) 		PF00560
(LRR_1)
PF01462
(LRRNT)
PF13855
(LRR_8) 		5 LEU A 251
LEU A 275
LEU A 295
ILE A 234
VAL A 267
 None
 1.03A 4mk4A-5lfnA:
undetectable		 4mk4A-5lfnA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m0o TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE

(Jeotgalicoccus
sp. ATCC 8456) 		PF00067
(p450) 		5 LEU A 142
LEU A 141
ILE A 374
THR A 123
HIS A 120
 None
None
None
None
SO4  A 503 (-3.8A)
 1.30A 4mk4A-5m0oA:
undetectable		 4mk4A-5m0oA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd4 TUBULIN ALPHA CHAIN

(Bos taurus) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		5 LEU A 153
LEU A 152
ARG A 123
LYS A 124
THR A 145
 None
None
None
None
GTP  A 500 (-4.0A)
 1.24A 4mk4A-5nd4A:
2.7		 4mk4A-5nd4A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oh6 INTERAPTIN

(Legionella
pneumophila) 		no annotation 5 LEU A 120
LEU A 181
ILE A 171
THR A 125
VAL A 224
 None
 1.24A 4mk4A-5oh6A:
undetectable		 4mk4A-5oh6A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7z ACID CERAMIDASE

(Homo sapiens) 		no annotation 5 LEU B 358
ARG B 334
THR B 372
HIS B 157
VAL B 316
 None
 1.40A 4mk4A-5u7zB:
undetectable		 4mk4A-5u7zB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uba RNA PSEUDOURIDYLATE
SYNTHASE
DOMAIN-CONTAINING
PROTEIN 4

(Homo sapiens) 		PF00849
(PseudoU_synth_2) 		5 LEU A 356
LEU A 308
LEU A 305
ILE A 188
HIS A 287
 None
 1.39A 4mk4A-5ubaA:
undetectable		 4mk4A-5ubaA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v6b PDZ
DOMAIN-CONTAINING
PROTEIN GIPC1

(Mus musculus) 		PF00595
(PDZ) 		5 LEU A 145
LEU A 198
LEU A 201
ILE A 157
VAL A 134
 None
 1.01A 4mk4A-5v6bA:
undetectable		 4mk4A-5v6bA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcu RAS-RELATED C3
BOTULINUM TOXIN
SUBSTRATE 1 ISOFORM
X2

(Naegleria
fowleri) 		PF00071
(Ras) 		5 LEU A  55
LEU A  20
ILE A   4
THR A  58
VAL A 111
 None
 1.41A 4mk4A-5vcuA:
2.6		 4mk4A-5vcuA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnp LEUCINE-RICH REPEAT
AND FIBRONECTIN
TYPE-III
DOMAIN-CONTAINING
PROTEIN 5

(Homo sapiens) 		no annotation 5 LEU A 130
LEU A 154
LEU A 176
ILE A 114
VAL A 146
 None
 1.29A 4mk4A-5xnpA:
undetectable		 4mk4A-5xnpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xu6 INOSITOL-PENTAKISPHO
SPHATE 2-KINASE

(Cryptococcus
neoformans) 		PF06090
(Ins_P5_2-kin) 		5 LEU A 247
LEU A 248
LEU A 255
ARG A 245
TRP A 219
 None
 1.24A 4mk4A-5xu6A:
undetectable		 4mk4A-5xu6A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y7y ARYL HYDROCARBON
RECEPTOR REPRESSOR
ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR

(Homo sapiens;
Bos taurus) 		PF00010
(HLH)
PF00989
(PAS)
PF00010
(HLH)
PF00989
(PAS)
PF14598
(PAS_11) 		5 LEU A  71
LEU A  51
LEU A  54
ILE B 109
VAL B 116
 None
 1.14A 4mk4A-5y7yA:
undetectable		 4mk4A-5y7yA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z24 PILUS ASSEMBLY
PROTEIN

(Lactobacillus
rhamnosus) 		no annotation 5 LEU A 436
LEU A 431
ILE A 409
THR A 378
VAL A 397
 None
 1.35A 4mk4A-5z24A:
undetectable		 4mk4A-5z24A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ar3 GSI-IIC RT

(Geobacillus
stearothermophilus) 		no annotation 5 LEU A 211
LEU A 207
LEU A 250
ARG A 214
ILE A 227
 None
 1.07A 4mk4A-6ar3A:
undetectable		 4mk4A-6ar3A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6beg SCAFFOLD PROTEIN D13

(Vaccinia virus) 		no annotation 5 LEU A 452
LEU A 443
ILE A 492
THR A 474
VAL A 246
 None
 1.31A 4mk4A-6begA:
undetectable		 4mk4A-6begA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6blg DTDP-4-AMINO-4,6-DID
EOXYGALACTOSE
TRANSAMINASE

(Klebsiella
pneumoniae) 		no annotation 5 LEU A 271
LEU A 372
ARG A 276
ILE A 277
THR A 366
 None
None
None
None
CL  A 410 (-3.6A)
 1.41A 4mk4A-6blgA:
undetectable		 4mk4A-6blgA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6l V-TYPE PROTON ATPASE
SUBUNIT A, VACUOLAR
ISOFORM
V-TYPE PROTON ATPASE
SUBUNIT D

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		no annotation
no annotation 		5 LEU A 207
LEU A 203
LEU A 199
ILE A 245
VAL B 141
 None
 1.39A 4mk4A-6c6lA:
undetectable		 4mk4A-6c6lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fe1 CARBONIC ANHYDRASE 9

(Homo sapiens) 		no annotation 5 LEU A 179
LEU A 160
LEU A 161
ILE A 181
VAL A 216
 None
 1.33A 4mk4A-6fe1A:
undetectable		 4mk4A-6fe1A:
undetectable