SIMILAR PATTERNS OF AMINO ACIDS FOR 4MJW_B_ACTB603_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ac5 KEX1(DELTA)P

(Saccharomyces
cerevisiae) 		PF00450
(Peptidase_S10) 		3 SER A 455
ARG A 459
HIS A 417
 None
 1.03A 4mjwA-1ac5A:
0.0
4mjwB-1ac5A:
1.3		 4mjwA-1ac5A:
22.22
4mjwB-1ac5A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ddg SULFITE REDUCTASE
(NADPH) FLAVOPROTEIN
ALPHA-COMPONENT

(Escherichia
coli) 		PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1) 		3 SER A 519
ARG A 520
HIS A 491
 None
 0.58A 4mjwA-1ddgA:
3.4
4mjwB-1ddgA:
undetectable		 4mjwA-1ddgA:
22.38
4mjwB-1ddgA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flo FLP RECOMBINASE

(Saccharomyces
cerevisiae) 		PF03930
(Flp_N)
PF05202
(Flp_C) 		3 SER A 193
ARG A 191
HIS A 305
 None
 0.87A 4mjwA-1floA:
undetectable
4mjwB-1floA:
undetectable		 4mjwA-1floA:
18.63
4mjwB-1floA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2d ATP SULFURYLASE

(Penicillium
chrysogenum) 		PF01583
(APS_kinase)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		3 SER A 216
ARG A 217
HIS A 287
 None
 0.83A 4mjwA-1i2dA:
0.5
4mjwB-1i2dA:
0.3		 4mjwA-1i2dA:
21.99
4mjwB-1i2dA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jne IMAGINAL DISC GROWTH
FACTOR-2

(Drosophila
melanogaster) 		PF00704
(Glyco_hydro_18) 		3 SER A 246
ARG A 249
HIS A 242
 None
None
MAN  A3103 (-3.8A)
 0.84A 4mjwA-1jneA:
0.0
4mjwB-1jneA:
0.0		 4mjwA-1jneA:
22.68
4mjwB-1jneA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kn6 PROHORMONE
CONVERTASE 1

(Mus musculus) 		PF16470
(S8_pro-domain) 		3 SER A  52
ARG A  53
HIS A  48
 None
 0.93A 4mjwA-1kn6A:
undetectable
4mjwB-1kn6A:
undetectable		 4mjwA-1kn6A:
10.57
4mjwB-1kn6A:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ldk CULLIN HOMOLOG

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		3 SER B 572
ARG B 573
HIS B 574
 None
 0.76A 4mjwA-1ldkB:
undetectable
4mjwB-1ldkB:
undetectable		 4mjwA-1ldkB:
20.40
4mjwB-1ldkB:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qvb BETA-GLYCOSIDASE

(Thermosphaera
aggregans) 		PF00232
(Glyco_hydro_1) 		3 SER A 457
ARG A 397
HIS A 423
 None
 0.76A 4mjwA-1qvbA:
0.0
4mjwB-1qvbA:
0.0		 4mjwA-1qvbA:
21.37
4mjwB-1qvbA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8q GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PERIPLASMIC

(Escherichia
coli) 		PF03009
(GDPD) 		3 SER A  40
ARG A  37
HIS A  46
 None
GOL  A1605 (-4.2A)
None
 0.86A 4mjwA-1t8qA:
undetectable
4mjwB-1t8qA:
undetectable		 4mjwA-1t8qA:
19.71
4mjwB-1t8qA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ufo HYPOTHETICAL PROTEIN
TT1662

(Thermus
thermophilus) 		no annotation 3 SER A 181
ARG A 182
HIS A 184
 None
 0.82A 4mjwA-1ufoA:
undetectable
4mjwB-1ufoA:
undetectable		 4mjwA-1ufoA:
19.74
4mjwB-1ufoA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uwi BETA-GALACTOSIDASE

(Sulfolobus
solfataricus) 		PF00232
(Glyco_hydro_1) 		3 SER A 458
ARG A 398
HIS A 424
 None
 0.74A 4mjwA-1uwiA:
undetectable
4mjwB-1uwiA:
undetectable		 4mjwA-1uwiA:
22.75
4mjwB-1uwiA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vi1 FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX

(Bacillus
subtilis) 		PF02504
(FA_synthesis) 		3 SER A  50
ARG A  52
HIS A  32
 None
 0.84A 4mjwA-1vi1A:
3.6
4mjwB-1vi1A:
3.8		 4mjwA-1vi1A:
21.18
4mjwB-1vi1A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1n SIXTEEN HEME
CYTOCHROME

(Desulfovibrio
gigas) 		PF02085
(Cytochrom_CIII)
PF14522
(Cytochrome_C7) 		3 SER X 194
ARG X 196
HIS X 200
 None
HEC  X 601 ( 3.3A)
HEC  X 607 ( 3.3A)
 0.84A 4mjwA-1z1nX:
undetectable
4mjwB-1z1nX:
undetectable		 4mjwA-1z1nX:
21.99
4mjwB-1z1nX:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e84 HIGH-MOLECULAR-WEIGH
T CYTOCHROME C

(Desulfovibrio
vulgaris) 		PF02085
(Cytochrom_CIII) 		3 SER A 219
ARG A 221
HIS A 225
 None
HEM  A1307 ( 3.2A)
HEM  A1307 ( 3.4A)
 0.86A 4mjwA-2e84A:
undetectable
4mjwB-2e84A:
undetectable		 4mjwA-2e84A:
22.62
4mjwB-2e84A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gh0 GDNF FAMILY RECEPTOR
ALPHA-3

(Homo sapiens) 		PF02351
(GDNF) 		3 SER A 286
ARG A 287
HIS A 271
 None
 0.93A 4mjwA-2gh0A:
undetectable
4mjwB-2gh0A:
undetectable		 4mjwA-2gh0A:
15.50
4mjwB-2gh0A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gw1 MITOCHONDRIAL
PRECURSOR PROTEINS
IMPORT RECEPTOR

(Saccharomyces
cerevisiae) 		PF00515
(TPR_1)
PF13181
(TPR_8)
PF13432
(TPR_16) 		3 SER A 365
ARG A 362
HIS A 335
 None
 0.90A 4mjwA-2gw1A:
undetectable
4mjwB-2gw1A:
undetectable		 4mjwA-2gw1A:
21.90
4mjwB-2gw1A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hj9 AUTOINDUCER
2-BINDING
PERIPLASMIC PROTEIN
LUXP

(Vibrio harveyi) 		PF13407
(Peripla_BP_4) 		3 SER A 117
ARG A 139
HIS A 140
 None
 0.85A 4mjwA-2hj9A:
undetectable
4mjwB-2hj9A:
undetectable		 4mjwA-2hj9A:
21.20
4mjwB-2hj9A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnh DNA POLYMERASE III
ALPHA SUBUNIT

(Escherichia
coli) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		3 SER A  16
ARG A 203
HIS A 213
 None
 0.99A 4mjwA-2hnhA:
undetectable
4mjwB-2hnhA:
0.0		 4mjwA-2hnhA:
23.14
4mjwB-2hnhA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9u CYTOSINE/GUANINE
DEAMINASE RELATED
PROTEIN

(Clostridium
acetobutylicum) 		PF01979
(Amidohydro_1) 		3 SER A 206
ARG A 202
HIS A 229
 None
GUN  A 503 (-3.7A)
GUN  A 503 ( 3.5A)
 1.01A 4mjwA-2i9uA:
undetectable
4mjwB-2i9uA:
undetectable		 4mjwA-2i9uA:
21.03
4mjwB-2i9uA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ja1 THYMIDINE KINASE

(Bacillus cereus) 		PF00265
(TK) 		3 SER A 153
ARG A 154
HIS A 187
 None
 0.93A 4mjwA-2ja1A:
undetectable
4mjwB-2ja1A:
undetectable		 4mjwA-2ja1A:
15.77
4mjwB-2ja1A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jdc GLYPHOSATE
N-ACETYLTRANSFERASE

(Bacillus
licheniformis) 		PF00583
(Acetyltransf_1) 		3 SER A 113
ARG A 111
HIS A 138
 CAO  A1147 (-4.2A)
SO4  A1148 ( 3.9A)
SO4  A1148 (-3.9A)
 0.88A 4mjwA-2jdcA:
undetectable
4mjwB-2jdcA:
1.3		 4mjwA-2jdcA:
15.47
4mjwB-2jdcA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2omk HYPOTHETICAL PROTEIN

(Bacteroides
thetaiotaomicron) 		PF04263
(TPK_catalytic) 		3 SER A  46
ARG A  47
HIS A  49
 None
 0.90A 4mjwA-2omkA:
undetectable
4mjwB-2omkA:
undetectable		 4mjwA-2omkA:
17.47
4mjwB-2omkA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		3 SER X 339
ARG X 340
HIS X 337
 None
 1.02A 4mjwA-2p3gX:
undetectable
4mjwB-2p3gX:
undetectable		 4mjwA-2p3gX:
19.82
4mjwB-2p3gX:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p76 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Staphylococcus
aureus) 		PF03009
(GDPD) 		3 SER A  63
ARG A  60
HIS A  69
 None
 0.46A 4mjwA-2p76A:
undetectable
4mjwB-2p76A:
undetectable		 4mjwA-2p76A:
19.21
4mjwB-2p76A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyx TRYPTOPHAN
HALOGENASE

(Shewanella
frigidimarina) 		PF04820
(Trp_halogenase) 		3 SER A 107
ARG A  92
HIS A 274
 None
 1.01A 4mjwA-2pyxA:
10.0
4mjwB-2pyxA:
10.0		 4mjwA-2pyxA:
21.50
4mjwB-2pyxA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qtz METHIONINE SYNTHASE
REDUCTASE

(Homo sapiens) 		PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1) 		3 SER A 610
ARG A 611
HIS A 582
 NAP  A 701 (-2.7A)
NAP  A 701 (-3.9A)
None
 0.64A 4mjwA-2qtzA:
4.4
4mjwB-2qtzA:
undetectable		 4mjwA-2qtzA:
21.74
4mjwB-2qtzA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vii PSP OPERON
TRANSCRIPTIONAL
ACTIVATOR

(Escherichia
coli) 		PF00158
(Sigma54_activat) 		3 SER A  54
ARG A  55
HIS A  50
 None
 0.99A 4mjwA-2viiA:
undetectable
4mjwB-2viiA:
undetectable		 4mjwA-2viiA:
20.86
4mjwB-2viiA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbp L-ARGININE
BETA-HYDROXYLASE

(Streptomyces
vinaceus) 		PF02668
(TauD) 		3 SER A 161
ARG A 162
HIS A 154
 None
 0.72A 4mjwA-2wbpA:
undetectable
4mjwB-2wbpA:
undetectable		 4mjwA-2wbpA:
23.98
4mjwB-2wbpA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wgy CYTOCHROME P450 130

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		3 SER A 105
ARG A 106
HIS A 215
 None
 0.92A 4mjwA-2wgyA:
undetectable
4mjwB-2wgyA:
undetectable		 4mjwA-2wgyA:
21.33
4mjwB-2wgyA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1i AMIDASE

(Rhodococcus sp.
N-771) 		PF01425
(Amidase) 		3 SER A 364
ARG A 365
HIS A 369
 None
 0.91A 4mjwA-3a1iA:
undetectable
4mjwB-3a1iA:
undetectable		 4mjwA-3a1iA:
25.48
4mjwB-3a1iA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a58 EXOCYST COMPLEX
COMPONENT SEC3

(Saccharomyces
cerevisiae) 		PF15277
(Sec3-PIP2_bind) 		3 SER A  95
ARG A  96
HIS A  99
 None
 0.91A 4mjwA-3a58A:
undetectable
4mjwB-3a58A:
undetectable		 4mjwA-3a58A:
19.60
4mjwB-3a58A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b5i S-ADENOSYL-L-METHION
INE:SALICYLIC ACID
CARBOXYL
METHYLTRANSFERASE-LI
KE PROTEIN

(Arabidopsis
thaliana) 		PF03492
(Methyltransf_7) 		3 SER A 349
ARG A 350
HIS A 246
 None
 0.98A 4mjwA-3b5iA:
undetectable
4mjwB-3b5iA:
undetectable		 4mjwA-3b5iA:
22.30
4mjwB-3b5iA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfg REGULATORY PROTEIN
RECX

(Xanthomonas
campestris) 		PF02631
(RecX) 		3 SER A  80
ARG A  77
HIS A  86
 None
 0.79A 4mjwA-3dfgA:
undetectable
4mjwB-3dfgA:
undetectable		 4mjwA-3dfgA:
15.31
4mjwB-3dfgA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dra GERANYLGERANYLTRANSF
ERASE TYPE I BETA
SUBUNIT

(Candida
albicans) 		PF00432
(Prenyltrans) 		3 SER B 343
ARG B 339
HIS B 349
 None
GRG  B1721 (-3.7A)
ZN  B 391 (-3.3A)
 0.95A 4mjwA-3draB:
undetectable
4mjwB-3draB:
undetectable		 4mjwA-3draB:
20.39
4mjwB-3draB:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e2i THYMIDINE KINASE

(Staphylococcus
aureus) 		PF00265
(TK) 		3 SER A 153
ARG A 154
HIS A 187
 None
 0.80A 4mjwA-3e2iA:
undetectable
4mjwB-3e2iA:
undetectable		 4mjwA-3e2iA:
17.71
4mjwB-3e2iA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eg5 PROTEIN DIAPHANOUS
HOMOLOG 1

(Mus musculus) 		PF06367
(Drf_FH3)
PF06371
(Drf_GBD) 		3 SER B 327
ARG B 326
HIS B 435
 None
 1.00A 4mjwA-3eg5B:
undetectable
4mjwB-3eg5B:
undetectable		 4mjwA-3eg5B:
21.04
4mjwB-3eg5B:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hxw ALANYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF01411
(tRNA-synt_2c) 		3 SER A  59
ARG A  60
HIS A  20
 None
 0.92A 4mjwA-3hxwA:
1.8
4mjwB-3hxwA:
undetectable		 4mjwA-3hxwA:
21.44
4mjwB-3hxwA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kd8 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Thermoplasma
acidophilum) 		PF01676
(Metalloenzyme)
PF10143
(PhosphMutase) 		3 SER A 222
ARG A 221
HIS A 164
 None
 0.98A 4mjwA-3kd8A:
undetectable
4mjwB-3kd8A:
2.3		 4mjwA-3kd8A:
22.36
4mjwB-3kd8A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lyr TRANSCRIPTION FACTOR
COE1

(Homo sapiens) 		PF16422
(COE1_DBD) 		3 SER A  65
ARG A  63
HIS A 235
 None
 0.96A 4mjwA-3lyrA:
undetectable
4mjwB-3lyrA:
undetectable		 4mjwA-3lyrA:
18.16
4mjwB-3lyrA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0a TYROSINE-PROTEIN
PHOSPHATASE AUXILIN

(Bos taurus) 		PF10409
(PTEN_C2) 		3 SER A  97
ARG A  98
HIS A  99
 None
 1.01A 4mjwA-3n0aA:
undetectable
4mjwB-3n0aA:
undetectable		 4mjwA-3n0aA:
20.43
4mjwB-3n0aA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0r RESPONSE REGULATOR

(Caulobacter
vibrioides) 		PF00072
(Response_reg) 		3 SER A  51
ARG A  53
HIS A  10
 None
 1.02A 4mjwA-3n0rA:
2.0
4mjwB-3n0rA:
1.8		 4mjwA-3n0rA:
21.20
4mjwB-3n0rA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3on2 PROBABLE
TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF00440
(TetR_N)
PF13305
(WHG) 		3 SER A  12
ARG A  14
HIS A  52
 None
 1.02A 4mjwA-3on2A:
undetectable
4mjwB-3on2A:
undetectable		 4mjwA-3on2A:
18.21
4mjwB-3on2A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE BETA-SUBUNIT

(Komagataella
pastoris) 		PF00365
(PFK) 		3 SER B 599
ARG B 600
HIS B 602
 None
 1.01A 4mjwA-3opyB:
undetectable
4mjwB-3opyB:
1.1		 4mjwA-3opyB:
20.88
4mjwB-3opyB:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pie 5'->3'
EXORIBONUCLEASE
(XRN1)

(Kluyveromyces
lactis) 		PF03159
(XRN_N) 		3 SER A 267
ARG A 375
HIS A 319
 None
 0.84A 4mjwA-3pieA:
undetectable
4mjwB-3pieA:
undetectable		 4mjwA-3pieA:
17.72
4mjwB-3pieA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pjp TRANSCRIPTION
ELONGATION FACTOR
SPT6

([Candida]
glabrata) 		PF14633
(SH2_2) 		3 SER A1284
ARG A1285
HIS A1289
 ACT  A1445 (-3.1A)
ACT  A1445 (-4.7A)
None
 0.91A 4mjwA-3pjpA:
undetectable
4mjwB-3pjpA:
undetectable		 4mjwA-3pjpA:
16.55
4mjwB-3pjpA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9t CHOLINE
DEHYDROGENASE AND
RELATED
FLAVOPROTEINS

(Aspergillus
oryzae) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		3 SER A 486
ARG A 316
HIS A 417
 None
 1.02A 4mjwA-3q9tA:
45.3
4mjwB-3q9tA:
45.2		 4mjwA-3q9tA:
29.76
4mjwB-3q9tA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s29 SUCROSE SYNTHASE 1

(Arabidopsis
thaliana) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		3 SER A 381
ARG A 382
HIS A 287
 None
FRU  A 902 (-4.1A)
FRU  A 902 (-4.0A)
 0.98A 4mjwA-3s29A:
2.0
4mjwB-3s29A:
undetectable		 4mjwA-3s29A:
22.13
4mjwB-3s29A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgg HYPOTHETICAL
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF14323
(GxGYxYP_C)
PF16216
(GxGYxYP_N) 		3 SER A 501
ARG A 502
HIS A 323
 None
 0.82A 4mjwA-3sggA:
undetectable
4mjwB-3sggA:
undetectable		 4mjwA-3sggA:
20.74
4mjwB-3sggA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sx2 PUTATIVE
3-KETOACYL-(ACYL-CAR
RIER-PROTEIN)
REDUCTASE

(Mycobacterium
avium) 		PF13561
(adh_short_C2) 		3 SER A  88
ARG A  84
HIS A 133
 None
 0.69A 4mjwA-3sx2A:
4.0
4mjwB-3sx2A:
3.7		 4mjwA-3sx2A:
19.78
4mjwB-3sx2A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vac CFA/I FIMBRIAL
SUBUNIT E

(Escherichia
coli) 		PF07434
(CblD) 		3 SER A  69
ARG A 182
HIS A 140
 None
 0.94A 4mjwA-3vacA:
undetectable
4mjwB-3vacA:
undetectable		 4mjwA-3vacA:
20.76
4mjwB-3vacA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wq8 BETA-GLUCOSIDASE

(Pyrococcus
furiosus) 		PF00232
(Glyco_hydro_1) 		3 SER A 443
ARG A 383
HIS A 409
 None
 0.63A 4mjwA-3wq8A:
undetectable
4mjwB-3wq8A:
undetectable		 4mjwA-3wq8A:
21.23
4mjwB-3wq8A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zif HEXON PROTEIN

(Bovine
mastadenovirus
B) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		3 SER A 574
ARG A 104
HIS A 521
 None
 0.85A 4mjwA-3zifA:
undetectable
4mjwB-3zifA:
undetectable		 4mjwA-3zifA:
20.11
4mjwB-3zifA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bhm MOSUB1 TRANSCRIPTION
COFACTOR

(Magnaporthe
oryzae) 		PF02229
(PC4) 		3 SER A 110
ARG A 111
HIS A 113
 None
None
SO4  A1117 (-3.7A)
 0.92A 4mjwA-4bhmA:
undetectable
4mjwB-4bhmA:
undetectable		 4mjwA-4bhmA:
9.94
4mjwB-4bhmA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d9r COMPLEMENT FACTOR D

(Homo sapiens) 		PF00089
(Trypsin) 		3 SER A 233
ARG A 179
HIS A 101
 None
 0.90A 4mjwA-4d9rA:
undetectable
4mjwB-4d9rA:
undetectable		 4mjwA-4d9rA:
18.93
4mjwB-4d9rA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eal 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
5'-AMP-ACTIVATED
PROTEIN KINASE
SUBUNIT BETA-1

(Rattus
norvegicus;
Rattus
norvegicus) 		PF16579
(AdenylateSensor)
PF04739
(AMPKBI) 		3 SER A 448
ARG A 464
HIS B 238
 None
 0.98A 4mjwA-4ealA:
4.7
4mjwB-4ealA:
5.3		 4mjwA-4ealA:
12.18
4mjwB-4ealA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ga7 LEUKOCYTE ELASTASE
INHIBITOR

(Homo sapiens) 		PF00079
(Serpin) 		3 SER A   6
ARG A  10
HIS A  59
 None
 0.67A 4mjwA-4ga7A:
undetectable
4mjwB-4ga7A:
undetectable		 4mjwA-4ga7A:
19.68
4mjwB-4ga7A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gq1 NUP37

(Schizosaccharomyces
pombe) 		PF00400
(WD40) 		3 SER A   5
ARG A 385
HIS A 372
 None
 1.02A 4mjwA-4gq1A:
undetectable
4mjwB-4gq1A:
undetectable		 4mjwA-4gq1A:
19.89
4mjwB-4gq1A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ha4 BETA-GALACTOSIDASE

(Acidilobus
saccharovorans) 		PF00232
(Glyco_hydro_1) 		3 SER A 456
ARG A 396
HIS A 422
 None
 0.71A 4mjwA-4ha4A:
undetectable
4mjwB-4ha4A:
undetectable		 4mjwA-4ha4A:
21.20
4mjwB-4ha4A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hnn DIHYDRODIPICOLINATE
SYNTHASE

(Vitis vinifera) 		PF00701
(DHDPS) 		3 SER A 106
ARG A 108
HIS A 112
 None
 0.87A 4mjwA-4hnnA:
undetectable
4mjwB-4hnnA:
undetectable		 4mjwA-4hnnA:
21.38
4mjwB-4hnnA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jnd CA(2+)/CALMODULIN-DE
PENDENT PROTEIN
KINASE PHOSPHATASE

(Caenorhabditis
elegans) 		PF00481
(PP2C) 		3 SER A 210
ARG A 178
HIS A  74
 None
 1.00A 4mjwA-4jndA:
undetectable
4mjwB-4jndA:
undetectable		 4mjwA-4jndA:
21.43
4mjwB-4jndA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lyl URACIL-DNA
GLYCOSYLASE

(Gadus morhua) 		PF03167
(UDG) 		3 SER A 114
ARG A 115
HIS A 116
 None
 0.97A 4mjwA-4lylA:
undetectable
4mjwB-4lylA:
undetectable		 4mjwA-4lylA:
16.36
4mjwB-4lylA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n4k HYDROXYLAMINE
OXIDOREDUCTASE

(Candidatus
Kuenenia
stuttgartiensis) 		PF13447
(Multi-haem_cyto) 		3 SER A 235
ARG A 240
HIS A 241
 HEM  A 608 (-2.5A)
HEM  A 608 (-3.6A)
HEM  A 608 ( 3.3A)
 0.95A 4mjwA-4n4kA:
undetectable
4mjwB-4n4kA:
undetectable		 4mjwA-4n4kA:
22.19
4mjwB-4n4kA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6e THIS/MOAD FAMILY
PROTEIN

(Amycolatopsis
orientalis) 		PF02597
(ThiS) 		3 SER B  37
ARG B  38
HIS B  39
 None
 0.89A 4mjwA-4n6eB:
undetectable
4mjwB-4n6eB:
undetectable		 4mjwA-4n6eB:
10.60
4mjwB-4n6eB:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q20 SENSOR PROTEIN DIVL

(Caulobacter
vibrioides) 		PF00512
(HisKA)
PF02518
(HATPase_c) 		3 SER A 573
ARG A 575
HIS A 579
 None
 1.01A 4mjwA-4q20A:
undetectable
4mjwB-4q20A:
undetectable		 4mjwA-4q20A:
18.49
4mjwB-4q20A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q60 PROLINE RACEMASE

(Burkholderia
multivorans) 		PF05544
(Pro_racemase) 		3 SER A 131
ARG A 286
HIS A 271
 None
 0.96A 4mjwA-4q60A:
undetectable
4mjwB-4q60A:
undetectable		 4mjwA-4q60A:
21.31
4mjwB-4q60A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7o GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PUTATIVE

(Bacillus
anthracis) 		PF03009
(GDPD) 		3 SER A  47
ARG A  44
HIS A  53
 None
 0.73A 4mjwA-4r7oA:
undetectable
4mjwB-4r7oA:
undetectable		 4mjwA-4r7oA:
19.69
4mjwB-4r7oA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rbn SUCROSE
SYNTHASE:GLYCOSYL
TRANSFERASES GROUP 1

(Nitrosomonas
europaea) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		3 SER A 368
ARG A 369
HIS A 273
 None
 0.91A 4mjwA-4rbnA:
undetectable
4mjwB-4rbnA:
2.5		 4mjwA-4rbnA:
22.51
4mjwB-4rbnA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgg PUTATIVE PHAGE
STRUCTURAL PROTEIN

(Lactococcus
phage 1358) 		no annotation 3 SER A 260
ARG A 370
HIS A 368
 None
 0.93A 4mjwA-4rggA:
undetectable
4mjwB-4rggA:
undetectable		 4mjwA-4rggA:
22.16
4mjwB-4rggA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u33 ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00128
(Alpha-amylase)
PF11896
(DUF3416) 		3 SER A 241
ARG A 240
HIS A 253
 None
 0.71A 4mjwA-4u33A:
undetectable
4mjwB-4u33A:
undetectable		 4mjwA-4u33A:
23.11
4mjwB-4u33A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uqf GTP CYCLOHYDROLASE 1

(Listeria
monocytogenes) 		PF01227
(GTP_cyclohydroI) 		3 SER A 104
ARG A 108
HIS A  54
 None
 0.95A 4mjwA-4uqfA:
undetectable
4mjwB-4uqfA:
undetectable		 4mjwA-4uqfA:
18.46
4mjwB-4uqfA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ut6 BROADLY NEUTRALIZING
HUMAN ANTIBODY EDE2
B7

(Homo sapiens) 		PF07686
(V-set) 		3 SER H  58
ARG H  50
HIS H  35
 None
 0.99A 4mjwA-4ut6H:
undetectable
4mjwB-4ut6H:
undetectable		 4mjwA-4ut6H:
18.99
4mjwB-4ut6H:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wrm MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR

(Homo sapiens) 		PF00047
(ig)
PF13927
(Ig_3) 		3 SER A 495
ARG A 486
HIS A 488
 None
 0.83A 4mjwA-4wrmA:
undetectable
4mjwB-4wrmA:
undetectable		 4mjwA-4wrmA:
23.21
4mjwB-4wrmA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x81 MYCINAMICIN III
3''-O-METHYLTRANSFER
ASE

(Micromonospora
griseorubida) 		PF05711
(TylF) 		3 SER A 155
ARG A 156
HIS A  54
 None
 1.02A 4mjwA-4x81A:
3.2
4mjwB-4x81A:
undetectable		 4mjwA-4x81A:
19.40
4mjwB-4x81A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xia D-XYLOSE ISOMERASE

(Arthrobacter
sp. NRRL B3728) 		PF01261
(AP_endonuc_2) 		3 SER A 393
ARG A 394
HIS A 389
 None
 0.69A 4mjwA-4xiaA:
undetectable
4mjwB-4xiaA:
undetectable		 4mjwA-4xiaA:
25.09
4mjwB-4xiaA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7z UNCHARACTERIZED
PROTEIN TM_0416

(Thermotoga
maritima) 		PF01261
(AP_endonuc_2) 		3 SER A  46
ARG A  94
HIS A  98
 None
 0.98A 4mjwA-5b7zA:
undetectable
4mjwB-5b7zA:
undetectable		 4mjwA-5b7zA:
18.81
4mjwB-5b7zA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cj5 ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE

(Mycolicibacterium
thermoresistibile) 		PF00128
(Alpha-amylase)
PF11896
(DUF3416) 		3 SER A 236
ARG A 235
HIS A 248
 None
 1.03A 4mjwA-5cj5A:
undetectable
4mjwB-5cj5A:
undetectable		 4mjwA-5cj5A:
22.63
4mjwB-5cj5A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cm9 RAL GUANINE
NUCLEOTIDE
DISSOCIATION
STIMULATOR-LIKE 2

(Mus musculus) 		PF00617
(RasGEF)
PF00618
(RasGEF_N) 		3 SER A 265
ARG A 125
HIS A 124
 None
 1.03A 4mjwA-5cm9A:
undetectable
4mjwB-5cm9A:
undetectable		 4mjwA-5cm9A:
22.71
4mjwB-5cm9A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cml OSMC FAMILY PROTEIN

(Rhodothermus
marinus) 		PF12146
(Hydrolase_4) 		3 SER A  51
ARG A  63
HIS A  36
 None
 1.02A 4mjwA-5cmlA:
undetectable
4mjwB-5cmlA:
undetectable		 4mjwA-5cmlA:
18.69
4mjwB-5cmlA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ctr SQUAMOUS CELL
CARCINOMA ANTIGEN
RECOGNIZED BY
T-CELLS 3

(Homo sapiens) 		no annotation 3 SER A 383
ARG A 384
HIS A 368
 None
 1.00A 4mjwA-5ctrA:
undetectable
4mjwB-5ctrA:
undetectable		 4mjwA-5ctrA:
21.45
4mjwB-5ctrA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus musculus) 		PF08696
(Dna2)
PF13086
(AAA_11)
PF13087
(AAA_12) 		3 SER A 268
ARG A 270
HIS A  99
 None
 0.87A 4mjwA-5eawA:
undetectable
4mjwB-5eawA:
undetectable		 4mjwA-5eawA:
19.96
4mjwB-5eawA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5et1 ESPIN

(Mus musculus) 		PF12796
(Ank_2)
PF13637
(Ank_4)
PF13857
(Ank_5) 		3 SER A 249
ARG A 250
HIS A 252
 None
 0.94A 4mjwA-5et1A:
undetectable
4mjwB-5et1A:
undetectable		 4mjwA-5et1A:
20.87
4mjwB-5et1A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fl3 PILI RETRACTION
PROTEIN PILT

(Thermus
thermophilus) 		PF00437
(T2SSE) 		3 SER A  25
ARG A  38
HIS A  28
 ADP  A 400 ( 3.9A)
None
None
 0.97A 4mjwA-5fl3A:
undetectable
4mjwB-5fl3A:
undetectable		 4mjwA-5fl3A:
21.09
4mjwB-5fl3A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h8a YTH
DOMAIN-CONTAINING
PROTEIN MMI1

(Schizosaccharomyces
pombe) 		PF04146
(YTH) 		3 SER A 350
ARG A 349
HIS A 348
 None
 0.99A 4mjwA-5h8aA:
undetectable
4mjwB-5h8aA:
undetectable		 4mjwA-5h8aA:
14.02
4mjwB-5h8aA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idq SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Burkholderia
vietnamiensis) 		PF00106
(adh_short) 		3 SER A 134
ARG A 131
HIS A 173
 None
 0.91A 4mjwA-5idqA:
4.1
4mjwB-5idqA:
undetectable		 4mjwA-5idqA:
19.60
4mjwB-5idqA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5it5 ATP BINDING
MOTIF-CONTAINING
PROTEIN PILF

(Thermus
thermophilus) 		no annotation 3 SER F 525
ARG F 541
HIS F 528
 None
 0.93A 4mjwA-5it5F:
undetectable
4mjwB-5it5F:
undetectable		 4mjwA-5it5F:
22.71
4mjwB-5it5F:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxl FLAGELLAR HOOK
PROTEIN FLGE

(Campylobacter
jejuni) 		PF00460
(Flg_bb_rod)
PF06429
(Flg_bbr_C)
PF07196
(Flagellin_IN)
PF07559
(FlaE) 		3 SER A  36
ARG A  77
HIS A  79
 None
 0.92A 4mjwA-5jxlA:
undetectable
4mjwB-5jxlA:
undetectable		 4mjwA-5jxlA:
23.40
4mjwB-5jxlA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jyj SPERM-EGG FUSION
PROTEIN JUNO

(Mus musculus) 		PF03024
(Folate_rec) 		3 SER A 197
ARG A 199
HIS A 219
 None
 0.86A 4mjwA-5jyjA:
undetectable
4mjwB-5jyjA:
undetectable		 4mjwA-5jyjA:
15.38
4mjwB-5jyjA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k7f TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Myxococcus
xanthus) 		PF00440
(TetR_N) 		3 SER A  78
ARG A  79
HIS A  96
 None
 0.51A 4mjwA-5k7fA:
undetectable
4mjwB-5k7fA:
undetectable		 4mjwA-5k7fA:
18.94
4mjwB-5k7fA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5knn ALANINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF01411
(tRNA-synt_2c) 		3 SER A  67
ARG A  68
HIS A  23
 None
 0.92A 4mjwA-5knnA:
undetectable
4mjwB-5knnA:
undetectable		 4mjwA-5knnA:
20.00
4mjwB-5knnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oyp STRUCTURAL PROTEIN
VP3

(Sacbrood virus) 		no annotation 3 SER C 135
ARG C 217
HIS C 151
 None
 0.92A 4mjwA-5oypC:
undetectable
4mjwB-5oypC:
undetectable		 4mjwA-5oypC:
undetectable
4mjwB-5oypC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t9c GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Bacillus
subtilis) 		PF03009
(GDPD) 		3 SER E  47
ARG E  44
HIS E  53
 PO4  E 303 ( 4.8A)
G3P  E 302 (-3.8A)
None
 0.76A 4mjwA-5t9cE:
undetectable
4mjwB-5t9cE:
undetectable		 4mjwA-5t9cE:
19.61
4mjwB-5t9cE:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1h OUTER MEMBRANE PORIN
F

(Pseudomonas
aeruginosa) 		PF00691
(OmpA) 		3 SER A  93
ARG A  94
HIS A  49
 None
 0.86A 4mjwA-5u1hA:
undetectable
4mjwB-5u1hA:
undetectable		 4mjwA-5u1hA:
12.64
4mjwB-5u1hA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v3n MONOPOLIN COMPLEX
SUBUNIT CSM1
ULP2P,TOPOISOMERASE
1-ASSOCIATED FACTOR
2 CHIMERA

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae x
Saccharomyces
kudriavzevii) 		PF12539
(Csm1)
no annotation 		3 SER B  33
ARG A  85
HIS A  87
 None
 1.02A 4mjwA-5v3nB:
undetectable
4mjwB-5v3nB:
undetectable		 4mjwA-5v3nB:
4.84
4mjwB-5v3nB:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vsj ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE
1

(Streptomyces
coelicolor) 		PF00128
(Alpha-amylase)
PF11896
(DUF3416) 		3 SER A 221
ARG A 220
HIS A 229
 None
 0.63A 4mjwA-5vsjA:
undetectable
4mjwB-5vsjA:
undetectable		 4mjwA-5vsjA:
24.75
4mjwB-5vsjA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgr SPIKE PROTEIN S1

(Pipistrellus
bat coronavirus
HKU5) 		PF09408
(Spike_rec_bind) 		3 SER A 149
ARG A 150
HIS A 159
 None
 1.01A 4mjwA-5xgrA:
undetectable
4mjwB-5xgrA:
undetectable		 4mjwA-5xgrA:
16.12
4mjwB-5xgrA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk5 UBIQUITIN LIGASE CBL

(Salpingoeca
rosetta) 		no annotation 3 SER A 271
ARG A 268
HIS A 267
 None
 0.88A 4mjwA-6bk5A:
undetectable
4mjwB-6bk5A:
undetectable		 4mjwA-6bk5A:
undetectable
4mjwB-6bk5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)

(Homo sapiens) 		no annotation 3 SER A1322
ARG A1326
HIS A1257
 None
 0.97A 4mjwA-6bq1A:
undetectable
4mjwB-6bq1A:
undetectable		 4mjwA-6bq1A:
undetectable
4mjwB-6bq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cri -

(-) 		no annotation 3 SER M 289
ARG M 290
HIS M 359
 None
 0.96A 4mjwA-6criM:
undetectable
4mjwB-6criM:
undetectable		 4mjwA-6criM:
undetectable
4mjwB-6criM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eh1 STRUCTURAL PROTEIN
VP3

(Sacbrood virus) 		no annotation 3 SER C 135
ARG C 217
HIS C 151
 None
 0.84A 4mjwA-6eh1C:
undetectable
4mjwB-6eh1C:
undetectable		 4mjwA-6eh1C:
undetectable
4mjwB-6eh1C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fb3 TENEURIN-2

(Gallus gallus) 		no annotation 3 SER A1846
ARG A1833
HIS A1817
 NAG  A3014 (-3.0A)
NAG  A3014 (-3.8A)
NAG  A3014 (-4.1A)
 1.02A 4mjwA-6fb3A:
undetectable
4mjwB-6fb3A:
undetectable		 4mjwA-6fb3A:
undetectable
4mjwB-6fb3A:
undetectable