SIMILAR PATTERNS OF AMINO ACIDS FOR 4MJW_A_ACTA603_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ac5 KEX1(DELTA)P

(Saccharomyces
cerevisiae) 		PF00450
(Peptidase_S10) 		3 ARG A 459
HIS A 417
SER A 455
 None
 1.03A 4mjwA-1ac5A:
0.0
4mjwB-1ac5A:
1.3		 4mjwA-1ac5A:
22.22
4mjwB-1ac5A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ddg SULFITE REDUCTASE
(NADPH) FLAVOPROTEIN
ALPHA-COMPONENT

(Escherichia
coli) 		PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1) 		3 ARG A 520
HIS A 491
SER A 519
 None
 0.62A 4mjwA-1ddgA:
0.0
4mjwB-1ddgA:
undetectable		 4mjwA-1ddgA:
22.38
4mjwB-1ddgA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flo FLP RECOMBINASE

(Saccharomyces
cerevisiae) 		PF03930
(Flp_N)
PF05202
(Flp_C) 		3 ARG A 191
HIS A 305
SER A 193
 None
 0.85A 4mjwA-1floA:
undetectable
4mjwB-1floA:
undetectable		 4mjwA-1floA:
18.63
4mjwB-1floA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2d ATP SULFURYLASE

(Penicillium
chrysogenum) 		PF01583
(APS_kinase)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		3 ARG A 217
HIS A 287
SER A 216
 None
 0.83A 4mjwA-1i2dA:
0.5
4mjwB-1i2dA:
0.3		 4mjwA-1i2dA:
21.99
4mjwB-1i2dA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jne IMAGINAL DISC GROWTH
FACTOR-2

(Drosophila
melanogaster) 		PF00704
(Glyco_hydro_18) 		3 ARG A 249
HIS A 242
SER A 246
 None
MAN  A3103 (-3.8A)
None
 0.89A 4mjwA-1jneA:
0.0
4mjwB-1jneA:
0.0		 4mjwA-1jneA:
22.68
4mjwB-1jneA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kn6 PROHORMONE
CONVERTASE 1

(Mus musculus) 		PF16470
(S8_pro-domain) 		3 ARG A  53
HIS A  48
SER A  52
 None
 0.98A 4mjwA-1kn6A:
undetectable
4mjwB-1kn6A:
undetectable		 4mjwA-1kn6A:
10.57
4mjwB-1kn6A:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ldk CULLIN HOMOLOG

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		3 ARG B 573
HIS B 574
SER B 572
 None
 0.79A 4mjwA-1ldkB:
undetectable
4mjwB-1ldkB:
undetectable		 4mjwA-1ldkB:
20.40
4mjwB-1ldkB:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qvb BETA-GLYCOSIDASE

(Thermosphaera
aggregans) 		PF00232
(Glyco_hydro_1) 		3 ARG A 397
HIS A 423
SER A 457
 None
 0.79A 4mjwA-1qvbA:
0.0
4mjwB-1qvbA:
0.0		 4mjwA-1qvbA:
21.37
4mjwB-1qvbA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8q GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PERIPLASMIC

(Escherichia
coli) 		PF03009
(GDPD) 		3 ARG A  37
HIS A  46
SER A  40
 GOL  A1605 (-4.2A)
None
None
 0.87A 4mjwA-1t8qA:
undetectable
4mjwB-1t8qA:
undetectable		 4mjwA-1t8qA:
19.71
4mjwB-1t8qA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ufo HYPOTHETICAL PROTEIN
TT1662

(Thermus
thermophilus) 		no annotation 3 ARG A 182
HIS A 184
SER A 181
 None
 0.85A 4mjwA-1ufoA:
undetectable
4mjwB-1ufoA:
undetectable		 4mjwA-1ufoA:
19.74
4mjwB-1ufoA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uwi BETA-GALACTOSIDASE

(Sulfolobus
solfataricus) 		PF00232
(Glyco_hydro_1) 		3 ARG A 398
HIS A 424
SER A 458
 None
 0.78A 4mjwA-1uwiA:
undetectable
4mjwB-1uwiA:
undetectable		 4mjwA-1uwiA:
22.75
4mjwB-1uwiA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vi1 FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX

(Bacillus
subtilis) 		PF02504
(FA_synthesis) 		3 ARG A  52
HIS A  32
SER A  50
 None
 0.82A 4mjwA-1vi1A:
3.8
4mjwB-1vi1A:
3.8		 4mjwA-1vi1A:
21.18
4mjwB-1vi1A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1n SIXTEEN HEME
CYTOCHROME

(Desulfovibrio
gigas) 		PF02085
(Cytochrom_CIII)
PF14522
(Cytochrome_C7) 		3 ARG X 196
HIS X 200
SER X 194
 HEC  X 601 ( 3.3A)
HEC  X 607 ( 3.3A)
None
 0.85A 4mjwA-1z1nX:
undetectable
4mjwB-1z1nX:
undetectable		 4mjwA-1z1nX:
21.99
4mjwB-1z1nX:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e84 HIGH-MOLECULAR-WEIGH
T CYTOCHROME C

(Desulfovibrio
vulgaris) 		PF02085
(Cytochrom_CIII) 		3 ARG A 221
HIS A 225
SER A 219
 HEM  A1307 ( 3.2A)
HEM  A1307 ( 3.4A)
None
 0.88A 4mjwA-2e84A:
undetectable
4mjwB-2e84A:
undetectable		 4mjwA-2e84A:
22.62
4mjwB-2e84A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gh0 GDNF FAMILY RECEPTOR
ALPHA-3

(Homo sapiens) 		PF02351
(GDNF) 		3 ARG A 287
HIS A 271
SER A 286
 None
 0.86A 4mjwA-2gh0A:
undetectable
4mjwB-2gh0A:
undetectable		 4mjwA-2gh0A:
15.50
4mjwB-2gh0A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hj9 AUTOINDUCER
2-BINDING
PERIPLASMIC PROTEIN
LUXP

(Vibrio harveyi) 		PF13407
(Peripla_BP_4) 		3 ARG A 139
HIS A 140
SER A 117
 None
 0.84A 4mjwA-2hj9A:
undetectable
4mjwB-2hj9A:
undetectable		 4mjwA-2hj9A:
21.20
4mjwB-2hj9A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnh DNA POLYMERASE III
ALPHA SUBUNIT

(Escherichia
coli) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		3 ARG A 203
HIS A 213
SER A  16
 None
 0.97A 4mjwA-2hnhA:
undetectable
4mjwB-2hnhA:
0.0		 4mjwA-2hnhA:
23.14
4mjwB-2hnhA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9u CYTOSINE/GUANINE
DEAMINASE RELATED
PROTEIN

(Clostridium
acetobutylicum) 		PF01979
(Amidohydro_1) 		3 ARG A 202
HIS A 229
SER A 206
 GUN  A 503 (-3.7A)
GUN  A 503 ( 3.5A)
None
 1.01A 4mjwA-2i9uA:
undetectable
4mjwB-2i9uA:
undetectable		 4mjwA-2i9uA:
21.03
4mjwB-2i9uA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ja1 THYMIDINE KINASE

(Bacillus cereus) 		PF00265
(TK) 		3 ARG A 154
HIS A 187
SER A 153
 None
 0.92A 4mjwA-2ja1A:
undetectable
4mjwB-2ja1A:
undetectable		 4mjwA-2ja1A:
15.77
4mjwB-2ja1A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jdc GLYPHOSATE
N-ACETYLTRANSFERASE

(Bacillus
licheniformis) 		PF00583
(Acetyltransf_1) 		3 ARG A 111
HIS A 138
SER A 113
 SO4  A1148 ( 3.9A)
SO4  A1148 (-3.9A)
CAO  A1147 (-4.2A)
 0.88A 4mjwA-2jdcA:
undetectable
4mjwB-2jdcA:
1.4		 4mjwA-2jdcA:
15.47
4mjwB-2jdcA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2omk HYPOTHETICAL PROTEIN

(Bacteroides
thetaiotaomicron) 		PF04263
(TPK_catalytic) 		3 ARG A  47
HIS A  49
SER A  46
 None
 0.92A 4mjwA-2omkA:
undetectable
4mjwB-2omkA:
undetectable		 4mjwA-2omkA:
17.47
4mjwB-2omkA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p76 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Staphylococcus
aureus) 		PF03009
(GDPD) 		3 ARG A  60
HIS A  69
SER A  63
 None
 0.47A 4mjwA-2p76A:
undetectable
4mjwB-2p76A:
undetectable		 4mjwA-2p76A:
19.21
4mjwB-2p76A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyx TRYPTOPHAN
HALOGENASE

(Shewanella
frigidimarina) 		PF04820
(Trp_halogenase) 		3 ARG A  92
HIS A 274
SER A 107
 None
 0.97A 4mjwA-2pyxA:
10.0
4mjwB-2pyxA:
10.0		 4mjwA-2pyxA:
21.50
4mjwB-2pyxA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qtz METHIONINE SYNTHASE
REDUCTASE

(Homo sapiens) 		PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1) 		3 ARG A 611
HIS A 582
SER A 610
 NAP  A 701 (-3.9A)
None
NAP  A 701 (-2.7A)
 0.68A 4mjwA-2qtzA:
4.4
4mjwB-2qtzA:
undetectable		 4mjwA-2qtzA:
21.74
4mjwB-2qtzA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbp L-ARGININE
BETA-HYDROXYLASE

(Streptomyces
vinaceus) 		PF02668
(TauD) 		3 ARG A 162
HIS A 154
SER A 161
 None
 0.73A 4mjwA-2wbpA:
undetectable
4mjwB-2wbpA:
undetectable		 4mjwA-2wbpA:
23.98
4mjwB-2wbpA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wgy CYTOCHROME P450 130

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		3 ARG A 106
HIS A 215
SER A 105
 None
 0.95A 4mjwA-2wgyA:
undetectable
4mjwB-2wgyA:
undetectable		 4mjwA-2wgyA:
21.33
4mjwB-2wgyA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1i AMIDASE

(Rhodococcus sp.
N-771) 		PF01425
(Amidase) 		3 ARG A 365
HIS A 369
SER A 364
 None
 0.94A 4mjwA-3a1iA:
undetectable
4mjwB-3a1iA:
undetectable		 4mjwA-3a1iA:
25.48
4mjwB-3a1iA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a58 EXOCYST COMPLEX
COMPONENT SEC3

(Saccharomyces
cerevisiae) 		PF15277
(Sec3-PIP2_bind) 		3 ARG A  96
HIS A  99
SER A  95
 None
 0.90A 4mjwA-3a58A:
undetectable
4mjwB-3a58A:
undetectable		 4mjwA-3a58A:
19.60
4mjwB-3a58A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b5i S-ADENOSYL-L-METHION
INE:SALICYLIC ACID
CARBOXYL
METHYLTRANSFERASE-LI
KE PROTEIN

(Arabidopsis
thaliana) 		PF03492
(Methyltransf_7) 		3 ARG A 350
HIS A 246
SER A 349
 None
 1.03A 4mjwA-3b5iA:
undetectable
4mjwB-3b5iA:
undetectable		 4mjwA-3b5iA:
22.30
4mjwB-3b5iA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfg REGULATORY PROTEIN
RECX

(Xanthomonas
campestris) 		PF02631
(RecX) 		3 ARG A  77
HIS A  86
SER A  80
 None
 0.80A 4mjwA-3dfgA:
undetectable
4mjwB-3dfgA:
undetectable		 4mjwA-3dfgA:
15.31
4mjwB-3dfgA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dra GERANYLGERANYLTRANSF
ERASE TYPE I BETA
SUBUNIT

(Candida
albicans) 		PF00432
(Prenyltrans) 		3 ARG B 339
HIS B 349
SER B 343
 GRG  B1721 (-3.7A)
ZN  B 391 (-3.3A)
None
 0.93A 4mjwA-3draB:
undetectable
4mjwB-3draB:
undetectable		 4mjwA-3draB:
20.39
4mjwB-3draB:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e2i THYMIDINE KINASE

(Staphylococcus
aureus) 		PF00265
(TK) 		3 ARG A 154
HIS A 187
SER A 153
 None
 0.77A 4mjwA-3e2iA:
undetectable
4mjwB-3e2iA:
undetectable		 4mjwA-3e2iA:
17.71
4mjwB-3e2iA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eg5 PROTEIN DIAPHANOUS
HOMOLOG 1

(Mus musculus) 		PF06367
(Drf_FH3)
PF06371
(Drf_GBD) 		3 ARG B 326
HIS B 435
SER B 327
 None
 1.03A 4mjwA-3eg5B:
undetectable
4mjwB-3eg5B:
undetectable		 4mjwA-3eg5B:
21.04
4mjwB-3eg5B:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hxw ALANYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF01411
(tRNA-synt_2c) 		3 ARG A  60
HIS A  20
SER A  59
 None
 0.84A 4mjwA-3hxwA:
1.7
4mjwB-3hxwA:
undetectable		 4mjwA-3hxwA:
21.44
4mjwB-3hxwA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kd8 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Thermoplasma
acidophilum) 		PF01676
(Metalloenzyme)
PF10143
(PhosphMutase) 		3 ARG A 221
HIS A 164
SER A 222
 None
 1.01A 4mjwA-3kd8A:
undetectable
4mjwB-3kd8A:
2.3		 4mjwA-3kd8A:
22.36
4mjwB-3kd8A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lws AROMATIC AMINO ACID
BETA-ELIMINATING
LYASE/THREONINE
ALDOLASE

(Exiguobacterium
sibiricum) 		PF01212
(Beta_elim_lyase) 		3 ARG A  79
HIS A 110
SER A  82
 None
 1.03A 4mjwA-3lwsA:
undetectable
4mjwB-3lwsA:
undetectable		 4mjwA-3lwsA:
22.42
4mjwB-3lwsA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lyr TRANSCRIPTION FACTOR
COE1

(Homo sapiens) 		PF16422
(COE1_DBD) 		3 ARG A  63
HIS A 235
SER A  65
 None
 0.98A 4mjwA-3lyrA:
undetectable
4mjwB-3lyrA:
undetectable		 4mjwA-3lyrA:
18.16
4mjwB-3lyrA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0a TYROSINE-PROTEIN
PHOSPHATASE AUXILIN

(Bos taurus) 		PF10409
(PTEN_C2) 		3 ARG A  98
HIS A  99
SER A  97
 None
 1.01A 4mjwA-3n0aA:
undetectable
4mjwB-3n0aA:
undetectable		 4mjwA-3n0aA:
20.43
4mjwB-3n0aA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0r RESPONSE REGULATOR

(Caulobacter
vibrioides) 		PF00072
(Response_reg) 		3 ARG A  53
HIS A  10
SER A  51
 None
 1.03A 4mjwA-3n0rA:
2.0
4mjwB-3n0rA:
1.8		 4mjwA-3n0rA:
21.20
4mjwB-3n0rA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE BETA-SUBUNIT

(Komagataella
pastoris) 		PF00365
(PFK) 		3 ARG B 600
HIS B 602
SER B 599
 None
 1.03A 4mjwA-3opyB:
undetectable
4mjwB-3opyB:
1.1		 4mjwA-3opyB:
20.88
4mjwB-3opyB:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8k HYDROLASE,
CARBON-NITROGEN
FAMILY

(Staphylococcus
aureus) 		PF00795
(CN_hydrolase) 		3 ARG A 176
HIS A 179
SER A 175
 PEG  A 265 (-4.3A)
None
None
 0.96A 4mjwA-3p8kA:
undetectable
4mjwB-3p8kA:
undetectable		 4mjwA-3p8kA:
19.96
4mjwB-3p8kA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pie 5'->3'
EXORIBONUCLEASE
(XRN1)

(Kluyveromyces
lactis) 		PF03159
(XRN_N) 		3 ARG A 375
HIS A 319
SER A 267
 None
 0.84A 4mjwA-3pieA:
undetectable
4mjwB-3pieA:
undetectable		 4mjwA-3pieA:
17.72
4mjwB-3pieA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pjp TRANSCRIPTION
ELONGATION FACTOR
SPT6

([Candida]
glabrata) 		PF14633
(SH2_2) 		3 ARG A1285
HIS A1289
SER A1284
 ACT  A1445 (-4.7A)
None
ACT  A1445 (-3.1A)
 0.86A 4mjwA-3pjpA:
undetectable
4mjwB-3pjpA:
undetectable		 4mjwA-3pjpA:
16.55
4mjwB-3pjpA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s29 SUCROSE SYNTHASE 1

(Arabidopsis
thaliana) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		3 ARG A 382
HIS A 287
SER A 381
 FRU  A 902 (-4.1A)
FRU  A 902 (-4.0A)
None
 0.94A 4mjwA-3s29A:
2.0
4mjwB-3s29A:
undetectable		 4mjwA-3s29A:
22.13
4mjwB-3s29A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s9b VIPERA RUSSELLI
PROTEINASE RVV-V
GAMMA

(Daboia
siamensis) 		PF00089
(Trypsin) 		3 ARG A 129
HIS A 210
SER A 134
 None
 1.01A 4mjwA-3s9bA:
undetectable
4mjwB-3s9bA:
undetectable		 4mjwA-3s9bA:
19.66
4mjwB-3s9bA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgg HYPOTHETICAL
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF14323
(GxGYxYP_C)
PF16216
(GxGYxYP_N) 		3 ARG A 502
HIS A 323
SER A 501
 None
 0.83A 4mjwA-3sggA:
undetectable
4mjwB-3sggA:
undetectable		 4mjwA-3sggA:
20.74
4mjwB-3sggA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sx2 PUTATIVE
3-KETOACYL-(ACYL-CAR
RIER-PROTEIN)
REDUCTASE

(Mycobacterium
avium) 		PF13561
(adh_short_C2) 		3 ARG A  84
HIS A 133
SER A  88
 None
 0.72A 4mjwA-3sx2A:
4.0
4mjwB-3sx2A:
3.7		 4mjwA-3sx2A:
19.78
4mjwB-3sx2A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vac CFA/I FIMBRIAL
SUBUNIT E

(Escherichia
coli) 		PF07434
(CblD) 		3 ARG A 182
HIS A 140
SER A  69
 None
 0.93A 4mjwA-3vacA:
undetectable
4mjwB-3vacA:
undetectable		 4mjwA-3vacA:
20.76
4mjwB-3vacA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wq8 BETA-GLUCOSIDASE

(Pyrococcus
furiosus) 		PF00232
(Glyco_hydro_1) 		3 ARG A 383
HIS A 409
SER A 443
 None
 0.66A 4mjwA-3wq8A:
undetectable
4mjwB-3wq8A:
undetectable		 4mjwA-3wq8A:
21.23
4mjwB-3wq8A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zif HEXON PROTEIN

(Bovine
mastadenovirus
B) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		3 ARG A 104
HIS A 521
SER A 574
 None
 0.81A 4mjwA-3zifA:
undetectable
4mjwB-3zifA:
undetectable		 4mjwA-3zifA:
20.11
4mjwB-3zifA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bhm MOSUB1 TRANSCRIPTION
COFACTOR

(Magnaporthe
oryzae) 		PF02229
(PC4) 		3 ARG A 111
HIS A 113
SER A 110
 None
SO4  A1117 (-3.7A)
None
 0.96A 4mjwA-4bhmA:
undetectable
4mjwB-4bhmA:
undetectable		 4mjwA-4bhmA:
9.94
4mjwB-4bhmA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d9r COMPLEMENT FACTOR D

(Homo sapiens) 		PF00089
(Trypsin) 		3 ARG A 179
HIS A 101
SER A 233
 None
 0.90A 4mjwA-4d9rA:
undetectable
4mjwB-4d9rA:
undetectable		 4mjwA-4d9rA:
18.93
4mjwB-4d9rA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eal 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
5'-AMP-ACTIVATED
PROTEIN KINASE
SUBUNIT BETA-1

(Rattus
norvegicus;
Rattus
norvegicus) 		PF16579
(AdenylateSensor)
PF04739
(AMPKBI) 		3 ARG A 464
HIS B 238
SER A 448
 None
 0.98A 4mjwA-4ealA:
4.7
4mjwB-4ealA:
5.3		 4mjwA-4ealA:
12.18
4mjwB-4ealA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fho INTERNALIN C2

(Listeria
monocytogenes) 		PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6) 		3 ARG A 214
HIS A 236
SER A 192
 SO4  A 600 (-2.7A)
None
None
 1.02A 4mjwA-4fhoA:
undetectable
4mjwB-4fhoA:
undetectable		 4mjwA-4fhoA:
19.58
4mjwB-4fhoA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ga7 LEUKOCYTE ELASTASE
INHIBITOR

(Homo sapiens) 		PF00079
(Serpin) 		3 ARG A  10
HIS A  59
SER A   6
 None
 0.63A 4mjwA-4ga7A:
undetectable
4mjwB-4ga7A:
undetectable		 4mjwA-4ga7A:
19.68
4mjwB-4ga7A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4giw RUN AND SH3
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF02759
(RUN) 		3 ARG A 117
HIS A 121
SER A 115
 None
 0.99A 4mjwA-4giwA:
undetectable
4mjwB-4giwA:
undetectable		 4mjwA-4giwA:
14.60
4mjwB-4giwA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gq1 NUP37

(Schizosaccharomyces
pombe) 		PF00400
(WD40) 		3 ARG A 385
HIS A 372
SER A   5
 None
 0.99A 4mjwA-4gq1A:
undetectable
4mjwB-4gq1A:
undetectable		 4mjwA-4gq1A:
19.89
4mjwB-4gq1A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ha4 BETA-GALACTOSIDASE

(Acidilobus
saccharovorans) 		PF00232
(Glyco_hydro_1) 		3 ARG A 396
HIS A 422
SER A 456
 None
 0.76A 4mjwA-4ha4A:
undetectable
4mjwB-4ha4A:
undetectable		 4mjwA-4ha4A:
21.20
4mjwB-4ha4A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hnn DIHYDRODIPICOLINATE
SYNTHASE

(Vitis vinifera) 		PF00701
(DHDPS) 		3 ARG A 108
HIS A 112
SER A 106
 None
 0.83A 4mjwA-4hnnA:
undetectable
4mjwB-4hnnA:
undetectable		 4mjwA-4hnnA:
21.38
4mjwB-4hnnA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jnd CA(2+)/CALMODULIN-DE
PENDENT PROTEIN
KINASE PHOSPHATASE

(Caenorhabditis
elegans) 		PF00481
(PP2C) 		3 ARG A 178
HIS A  74
SER A 210
 None
 0.98A 4mjwA-4jndA:
undetectable
4mjwB-4jndA:
undetectable		 4mjwA-4jndA:
21.43
4mjwB-4jndA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lyl URACIL-DNA
GLYCOSYLASE

(Gadus morhua) 		PF03167
(UDG) 		3 ARG A 115
HIS A 116
SER A 114
 None
 1.02A 4mjwA-4lylA:
undetectable
4mjwB-4lylA:
undetectable		 4mjwA-4lylA:
16.36
4mjwB-4lylA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n4k HYDROXYLAMINE
OXIDOREDUCTASE

(Candidatus
Kuenenia
stuttgartiensis) 		PF13447
(Multi-haem_cyto) 		3 ARG A 240
HIS A 241
SER A 235
 HEM  A 608 (-3.6A)
HEM  A 608 ( 3.3A)
HEM  A 608 (-2.5A)
 0.91A 4mjwA-4n4kA:
undetectable
4mjwB-4n4kA:
undetectable		 4mjwA-4n4kA:
22.19
4mjwB-4n4kA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6e THIS/MOAD FAMILY
PROTEIN

(Amycolatopsis
orientalis) 		PF02597
(ThiS) 		3 ARG B  38
HIS B  39
SER B  37
 None
 0.91A 4mjwA-4n6eB:
undetectable
4mjwB-4n6eB:
undetectable		 4mjwA-4n6eB:
10.60
4mjwB-4n6eB:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nq3 CYANURIC ACID
AMIDOHYDROLASE

(Azorhizobium
caulinodans) 		PF09663
(Amido_AtzD_TrzD) 		3 ARG A 222
HIS A 253
SER A 220
 None
 1.00A 4mjwA-4nq3A:
undetectable
4mjwB-4nq3A:
undetectable		 4mjwA-4nq3A:
22.32
4mjwB-4nq3A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pc9 C4-DICARBOXYLATE
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN, PUTATIVE

(Roseobacter
denitrificans) 		PF03480
(DctP) 		3 ARG A 151
HIS A 233
SER A 236
 CS2  A 401 (-3.0A)
None
None
 1.02A 4mjwA-4pc9A:
undetectable
4mjwB-4pc9A:
undetectable		 4mjwA-4pc9A:
23.97
4mjwB-4pc9A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q20 SENSOR PROTEIN DIVL

(Caulobacter
vibrioides) 		PF00512
(HisKA)
PF02518
(HATPase_c) 		3 ARG A 575
HIS A 579
SER A 573
 None
 1.00A 4mjwA-4q20A:
undetectable
4mjwB-4q20A:
undetectable		 4mjwA-4q20A:
18.49
4mjwB-4q20A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q60 PROLINE RACEMASE

(Burkholderia
multivorans) 		PF05544
(Pro_racemase) 		3 ARG A 286
HIS A 271
SER A 131
 None
 0.95A 4mjwA-4q60A:
undetectable
4mjwB-4q60A:
undetectable		 4mjwA-4q60A:
21.31
4mjwB-4q60A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7o GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PUTATIVE

(Bacillus
anthracis) 		PF03009
(GDPD) 		3 ARG A  44
HIS A  53
SER A  47
 None
 0.76A 4mjwA-4r7oA:
undetectable
4mjwB-4r7oA:
undetectable		 4mjwA-4r7oA:
19.69
4mjwB-4r7oA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rbn SUCROSE
SYNTHASE:GLYCOSYL
TRANSFERASES GROUP 1

(Nitrosomonas
europaea) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		3 ARG A 369
HIS A 273
SER A 368
 None
 0.88A 4mjwA-4rbnA:
undetectable
4mjwB-4rbnA:
2.6		 4mjwA-4rbnA:
22.51
4mjwB-4rbnA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgg PUTATIVE PHAGE
STRUCTURAL PROTEIN

(Lactococcus
phage 1358) 		no annotation 3 ARG A 370
HIS A 368
SER A 260
 None
 0.94A 4mjwA-4rggA:
undetectable
4mjwB-4rggA:
undetectable		 4mjwA-4rggA:
22.16
4mjwB-4rggA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u33 ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00128
(Alpha-amylase)
PF11896
(DUF3416) 		3 ARG A 240
HIS A 253
SER A 241
 None
 0.71A 4mjwA-4u33A:
undetectable
4mjwB-4u33A:
undetectable		 4mjwA-4u33A:
23.11
4mjwB-4u33A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uqf GTP CYCLOHYDROLASE 1

(Listeria
monocytogenes) 		PF01227
(GTP_cyclohydroI) 		3 ARG A 108
HIS A  54
SER A 104
 None
 0.87A 4mjwA-4uqfA:
undetectable
4mjwB-4uqfA:
undetectable		 4mjwA-4uqfA:
18.46
4mjwB-4uqfA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ut6 BROADLY NEUTRALIZING
HUMAN ANTIBODY EDE2
B7

(Homo sapiens) 		PF07686
(V-set) 		3 ARG H  50
HIS H  35
SER H  58
 None
 0.97A 4mjwA-4ut6H:
undetectable
4mjwB-4ut6H:
undetectable		 4mjwA-4ut6H:
18.99
4mjwB-4ut6H:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wrm MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR

(Homo sapiens) 		PF00047
(ig)
PF13927
(Ig_3) 		3 ARG A 486
HIS A 488
SER A 495
 None
 0.84A 4mjwA-4wrmA:
undetectable
4mjwB-4wrmA:
undetectable		 4mjwA-4wrmA:
23.21
4mjwB-4wrmA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x81 MYCINAMICIN III
3''-O-METHYLTRANSFER
ASE

(Micromonospora
griseorubida) 		PF05711
(TylF) 		3 ARG A 156
HIS A  54
SER A 155
 None
 1.02A 4mjwA-4x81A:
3.2
4mjwB-4x81A:
undetectable		 4mjwA-4x81A:
19.40
4mjwB-4x81A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xia D-XYLOSE ISOMERASE

(Arthrobacter
sp. NRRL B3728) 		PF01261
(AP_endonuc_2) 		3 ARG A 394
HIS A 389
SER A 393
 None
 0.66A 4mjwA-4xiaA:
undetectable
4mjwB-4xiaA:
undetectable		 4mjwA-4xiaA:
25.09
4mjwB-4xiaA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0c TOLL-LIKE RECEPTOR
13

(Mus musculus) 		PF00560
(LRR_1)
PF13516
(LRR_6)
PF13855
(LRR_8) 		3 ARG A 453
HIS A 429
SER A 452
 None
 0.99A 4mjwA-4z0cA:
undetectable
4mjwB-4z0cA:
undetectable		 4mjwA-4z0cA:
19.19
4mjwB-4z0cA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7z UNCHARACTERIZED
PROTEIN TM_0416

(Thermotoga
maritima) 		PF01261
(AP_endonuc_2) 		3 ARG A  94
HIS A  98
SER A  46
 None
 0.93A 4mjwA-5b7zA:
undetectable
4mjwB-5b7zA:
undetectable		 4mjwA-5b7zA:
18.81
4mjwB-5b7zA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cj5 ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE

(Mycolicibacterium
thermoresistibile) 		PF00128
(Alpha-amylase)
PF11896
(DUF3416) 		3 ARG A 235
HIS A 248
SER A 236
 None
 1.01A 4mjwA-5cj5A:
undetectable
4mjwB-5cj5A:
undetectable		 4mjwA-5cj5A:
22.63
4mjwB-5cj5A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cml OSMC FAMILY PROTEIN

(Rhodothermus
marinus) 		PF12146
(Hydrolase_4) 		3 ARG A  63
HIS A  36
SER A  51
 None
 0.98A 4mjwA-5cmlA:
undetectable
4mjwB-5cmlA:
undetectable		 4mjwA-5cmlA:
18.69
4mjwB-5cmlA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5doi TELOMERASE-ASSOCIATE
D PROTEIN 19

(Tetrahymena
thermophila) 		no annotation 3 ARG A 128
HIS A 142
SER A  36
 None
 1.03A 4mjwA-5doiA:
undetectable
4mjwB-5doiA:
undetectable		 4mjwA-5doiA:
13.67
4mjwB-5doiA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus musculus) 		PF08696
(Dna2)
PF13086
(AAA_11)
PF13087
(AAA_12) 		3 ARG A 270
HIS A  99
SER A 268
 None
 0.87A 4mjwA-5eawA:
undetectable
4mjwB-5eawA:
undetectable		 4mjwA-5eawA:
19.96
4mjwB-5eawA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5et1 ESPIN

(Mus musculus) 		PF12796
(Ank_2)
PF13637
(Ank_4)
PF13857
(Ank_5) 		3 ARG A 250
HIS A 252
SER A 249
 None
 0.94A 4mjwA-5et1A:
undetectable
4mjwB-5et1A:
undetectable		 4mjwA-5et1A:
20.87
4mjwB-5et1A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h8a YTH
DOMAIN-CONTAINING
PROTEIN MMI1

(Schizosaccharomyces
pombe) 		PF04146
(YTH) 		3 ARG A 349
HIS A 348
SER A 350
 None
 1.01A 4mjwA-5h8aA:
undetectable
4mjwB-5h8aA:
undetectable		 4mjwA-5h8aA:
14.02
4mjwB-5h8aA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idq SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Burkholderia
vietnamiensis) 		PF00106
(adh_short) 		3 ARG A 131
HIS A 173
SER A 134
 None
 0.87A 4mjwA-5idqA:
4.1
4mjwB-5idqA:
undetectable		 4mjwA-5idqA:
19.60
4mjwB-5idqA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxl FLAGELLAR HOOK
PROTEIN FLGE

(Campylobacter
jejuni) 		PF00460
(Flg_bb_rod)
PF06429
(Flg_bbr_C)
PF07196
(Flagellin_IN)
PF07559
(FlaE) 		3 ARG A  77
HIS A  79
SER A  36
 None
 0.87A 4mjwA-5jxlA:
undetectable
4mjwB-5jxlA:
undetectable		 4mjwA-5jxlA:
23.40
4mjwB-5jxlA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jyj SPERM-EGG FUSION
PROTEIN JUNO

(Mus musculus) 		PF03024
(Folate_rec) 		3 ARG A 199
HIS A 219
SER A 197
 None
 0.86A 4mjwA-5jyjA:
undetectable
4mjwB-5jyjA:
undetectable		 4mjwA-5jyjA:
15.38
4mjwB-5jyjA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k7f TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Myxococcus
xanthus) 		PF00440
(TetR_N) 		3 ARG A  79
HIS A  96
SER A  78
 None
 0.52A 4mjwA-5k7fA:
undetectable
4mjwB-5k7fA:
undetectable		 4mjwA-5k7fA:
18.94
4mjwB-5k7fA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5knn ALANINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF01411
(tRNA-synt_2c) 		3 ARG A  68
HIS A  23
SER A  67
 None
 0.88A 4mjwA-5knnA:
undetectable
4mjwB-5knnA:
0.3		 4mjwA-5knnA:
20.00
4mjwB-5knnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oyp STRUCTURAL PROTEIN
VP3

(Sacbrood virus) 		no annotation 3 ARG C 217
HIS C 151
SER C 135
 None
 0.96A 4mjwA-5oypC:
undetectable
4mjwB-5oypC:
undetectable		 4mjwA-5oypC:
undetectable
4mjwB-5oypC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t9c GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Bacillus
subtilis) 		PF03009
(GDPD) 		3 ARG E  44
HIS E  53
SER E  47
 G3P  E 302 (-3.8A)
None
PO4  E 303 ( 4.8A)
 0.77A 4mjwA-5t9cE:
undetectable
4mjwB-5t9cE:
undetectable		 4mjwA-5t9cE:
19.61
4mjwB-5t9cE:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1h OUTER MEMBRANE PORIN
F

(Pseudomonas
aeruginosa) 		PF00691
(OmpA) 		3 ARG A  94
HIS A  49
SER A  93
 None
 0.88A 4mjwA-5u1hA:
undetectable
4mjwB-5u1hA:
undetectable		 4mjwA-5u1hA:
12.64
4mjwB-5u1hA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v3n MONOPOLIN COMPLEX
SUBUNIT CSM1
ULP2P,TOPOISOMERASE
1-ASSOCIATED FACTOR
2 CHIMERA

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae x
Saccharomyces
kudriavzevii) 		PF12539
(Csm1)
no annotation 		3 ARG A  85
HIS A  87
SER B  33
 None
 1.00A 4mjwA-5v3nA:
undetectable
4mjwB-5v3nA:
undetectable		 4mjwA-5v3nA:
12.16
4mjwB-5v3nA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vsj ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE
1

(Streptomyces
coelicolor) 		PF00128
(Alpha-amylase)
PF11896
(DUF3416) 		3 ARG A 220
HIS A 229
SER A 221
 None
 0.64A 4mjwA-5vsjA:
undetectable
4mjwB-5vsjA:
undetectable		 4mjwA-5vsjA:
24.75
4mjwB-5vsjA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zln TOLL-LIKE RECEPTOR 9

(Mus musculus) 		no annotation 3 ARG A 353
HIS A 355
SER A 378
 None
SO4  A 916 (-4.0A)
None
 0.93A 4mjwA-5zlnA:
undetectable
4mjwB-5zlnA:
undetectable		 4mjwA-5zlnA:
undetectable
4mjwB-5zlnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk5 UBIQUITIN LIGASE CBL

(Salpingoeca
rosetta) 		no annotation 3 ARG A 268
HIS A 267
SER A 271
 None
 0.91A 4mjwA-6bk5A:
undetectable
4mjwB-6bk5A:
undetectable		 4mjwA-6bk5A:
undetectable
4mjwB-6bk5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)

(Homo sapiens) 		no annotation 3 ARG A1326
HIS A1257
SER A1322
 None
 0.91A 4mjwA-6bq1A:
undetectable
4mjwB-6bq1A:
undetectable		 4mjwA-6bq1A:
undetectable
4mjwB-6bq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cri -

(-) 		no annotation 3 ARG M 290
HIS M 359
SER M 289
 None
 0.95A 4mjwA-6criM:
undetectable
4mjwB-6criM:
undetectable		 4mjwA-6criM:
undetectable
4mjwB-6criM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eh1 STRUCTURAL PROTEIN
VP3

(Sacbrood virus) 		no annotation 3 ARG C 217
HIS C 151
SER C 135
 None
 0.88A 4mjwA-6eh1C:
undetectable
4mjwB-6eh1C:
undetectable		 4mjwA-6eh1C:
undetectable
4mjwB-6eh1C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fa5 PUTATIVE MRNA
SPLICING FACTOR

(Chaetomium
thermophilum) 		no annotation 3 ARG A 906
HIS A 877
SER A 907
 None
 1.03A 4mjwA-6fa5A:
undetectable
4mjwB-6fa5A:
undetectable		 4mjwA-6fa5A:
undetectable
4mjwB-6fa5A:
undetectable