SIMILAR PATTERNS OF AMINO ACIDS FOR 4MJR_A_0LAA404

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a4s BETAINE ALDEHYDE
DEHYDROGENASE

(Gadus morhua) 		PF00171
(Aldedh) 		5 ARG A 476
TYR A 485
GLY A 468
LEU A 264
VAL A 243
 None
 1.42A 4mjrA-1a4sA:
undetectable		 4mjrA-1a4sA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f6d UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Escherichia
coli) 		PF02350
(Epimerase_2) 		5 ARG A 121
THR A 138
GLY A 139
VAL A  92
VAL A 113
 None
 1.49A 4mjrA-1f6dA:
undetectable		 4mjrA-1f6dA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gke TRANSTHYRETIN

(Rattus
norvegicus) 		PF00576
(Transthyretin) 		5 TYR A  78
THR A  49
GLY A  53
LEU A  55
VAL A  14
 None
 1.22A 4mjrA-1gkeA:
undetectable		 4mjrA-1gkeA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lox 15-LIPOXYGENASE

(Oryctolagus
cuniculus) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		5 TYR A  56
GLY A  28
LEU A  26
VAL A  83
VAL A  63
 None
 1.20A 4mjrA-1loxA:
undetectable		 4mjrA-1loxA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqq ALPHA-D-GLUCURONIDAS
E

(Geobacillus
stearothermophilus) 		PF03648
(Glyco_hydro_67N)
PF07477
(Glyco_hydro_67C)
PF07488
(Glyco_hydro_67M) 		5 TYR A 293
GLY A 300
LEU A 304
VAL A 280
VAL A 315
 None
 1.47A 4mjrA-1mqqA:
0.0		 4mjrA-1mqqA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozh ACETOLACTATE
SYNTHASE, CATABOLIC

(Klebsiella
pneumoniae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 TYR A 242
THR A 239
GLY A 268
LEU A 213
VAL A 278
 None
 1.45A 4mjrA-1ozhA:
undetectable		 4mjrA-1ozhA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ton TONIN

(Rattus rattus) 		PF00089
(Trypsin) 		5 TYR A  94
THR A  54
GLY A 196
VAL A  33
VAL A  31
 None
 1.48A 4mjrA-1tonA:
undetectable		 4mjrA-1tonA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e9f ARGININOSUCCINATE
LYASE

(Thermus
thermophilus) 		PF00206
(Lyase_1)
PF14698
(ASL_C2) 		5 ARG A 162
THR A 368
GLY A 365
LEU A 369
PRO A 165
 None
 1.42A 4mjrA-2e9fA:
0.0		 4mjrA-2e9fA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ixf ANTIGEN PEPTIDE
TRANSPORTER 1

(Rattus
norvegicus) 		PF00005
(ABC_tran) 		5 TYR A 506
THR A 672
GLY A 478
LEU A 640
VAL A 558
 None
 1.11A 4mjrA-2ixfA:
undetectable		 4mjrA-2ixfA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jax HYPOTHETICAL PROTEIN
TB31.7

(Mycobacterium
tuberculosis) 		PF00582
(Usp) 		5 ARG A 266
LEU A 193
PRO A 245
VAL A 241
VAL A 239
 ATP  A1295 ( 4.6A)
None
ATP  A1295 (-4.6A)
None
None
 1.44A 4mjrA-2jaxA:
undetectable		 4mjrA-2jaxA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2waa XYLAN ESTERASE,
PUTATIVE, AXE2C

(Cellvibrio
japonicus) 		PF13472
(Lipase_GDSL_2) 		5 TYR A 248
THR A 291
GLY A 289
LEU A 295
VAL A 300
 None
 1.43A 4mjrA-2waaA:
undetectable		 4mjrA-2waaA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ypq PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE AROG

(Mycobacterium
tuberculosis) 		PF01474
(DAHP_synth_2) 		5 ARG A 286
TYR A 319
GLY A 308
LEU A 347
VAL A 343
 None
 1.31A 4mjrA-2ypqA:
undetectable		 4mjrA-2ypqA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z01 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Geobacillus
kaustophilus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 ARG A  53
GLY A  51
LEU A  47
PRO A  55
VAL A 160
 None
 1.30A 4mjrA-2z01A:
undetectable		 4mjrA-2z01A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b85 PHOSPHATE
STARVATION-INDUCIBLE
PROTEIN

(Corynebacterium
glutamicum) 		PF02562
(PhoH) 		5 ARG A 231
THR A 170
LEU A 240
VAL A 266
MET A 264
 None
 1.00A 4mjrA-3b85A:
undetectable		 4mjrA-3b85A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c30 AUTOINDUCER 2 SENSOR
KINASE/PHOSPHATASE
LUXQ

(Vibrio cholerae) 		PF09308
(LuxQ-periplasm) 		5 TYR A 133
GLY A 189
LEU A 143
VAL A 156
VAL A 147
 None
 1.47A 4mjrA-3c30A:
1.3		 4mjrA-3c30A:
22.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3f1v DNA POLYMERASE III
SUBUNIT BETA

(Escherichia
coli) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		8 TYR A 154
THR A 172
GLY A 174
LEU A 177
PRO A 242
VAL A 247
VAL A 360
MET A 362
 None
 0.92A 4mjrA-3f1vA:
50.2		 4mjrA-3f1vA:
98.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jr3 NAD-DEPENDENT
DEACETYLASE

(Thermotoga
maritima) 		PF02146
(SIR2) 		5 THR A  20
GLY A  21
LEU A 187
VAL A 232
VAL A 213
 None
 1.05A 4mjrA-3jr3A:
undetectable		 4mjrA-3jr3A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ot5 UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Listeria
monocytogenes) 		PF02350
(Epimerase_2) 		5 THR A 316
GLY A 315
LEU A 317
PRO A 350
VAL A 301
 None
 1.36A 4mjrA-3ot5A:
undetectable		 4mjrA-3ot5A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tw0 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF00092
(VWA) 		5 THR A 271
LEU A 269
PRO A 336
VAL A 252
VAL A 226
 None
 1.15A 4mjrA-3tw0A:
undetectable		 4mjrA-3tw0A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ux8 EXCINUCLEASE ABC, A
SUBUNIT

(Geobacillus sp.
Y412MC52) 		PF00005
(ABC_tran) 		5 ARG A 766
TYR A 767
GLY A 820
VAL A 789
MET A 817
 None
 1.43A 4mjrA-3ux8A:
undetectable		 4mjrA-3ux8A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w3s TYPE-2 SERINE--TRNA
LIGASE

(Methanopyrus
kandleri) 		PF00587
(tRNA-synt_2b) 		5 GLY A 471
LEU A 474
PRO A 333
VAL A 331
VAL A 466
 None
 1.44A 4mjrA-3w3sA:
undetectable		 4mjrA-3w3sA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wiq KOJIBIOSE
PHOSPHORYLASE

(Caldicellulosiruptor
saccharolyticus) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		5 THR A  49
GLY A  48
LEU A  68
PRO A  71
VAL A  66
 None
 1.50A 4mjrA-3wiqA:
undetectable		 4mjrA-3wiqA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jo0 CMLA

(Streptomyces
venezuelae) 		PF12706
(Lactamase_B_2) 		5 TYR A  22
GLY A 340
LEU A 345
VAL A 328
VAL A 353
 None
 1.20A 4mjrA-4jo0A:
undetectable		 4mjrA-4jo0A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 TYR A 276
GLY A 250
LEU A 255
PRO A 262
VAL A 176
 None
 1.46A 4mjrA-4o38A:
undetectable		 4mjrA-4o38A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zlv ORNITHINE
AMINOTRANSFERASE,
MITOCHONDRIAL,
PUTATIVE

(Toxoplasma
gondii) 		PF00202
(Aminotran_3) 		5 TYR A 171
GLY A 136
LEU A 283
VAL A 298
MET A 133
 None
PLP  A 501 (-3.1A)
None
None
None
 1.08A 4mjrA-4zlvA:
undetectable		 4mjrA-4zlvA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkv ESTERASE A

(Caulobacter
vibrioides) 		PF00144
(Beta-lactamase) 		5 TYR A 319
THR A  69
GLY A 330
LEU A  66
VAL A 349
 None
 1.31A 4mjrA-5gkvA:
0.4		 4mjrA-5gkvA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ix1 MORC FAMILY CW-TYPE
ZINC FINGER PROTEIN
3

(Mus musculus) 		PF07496
(zf-CW)
PF13589
(HATPase_c_3) 		5 ARG A 263
TYR A  41
THR A  90
GLY A  93
PRO A  43
 None
 1.46A 4mjrA-5ix1A:
undetectable		 4mjrA-5ix1A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msw THIOESTER REDUCTASE
DOMAIN-CONTAINING
PROTEIN

(Segniliparus
rugosus) 		PF00501
(AMP-binding)
PF00550
(PP-binding) 		5 TYR A 137
GLY A 144
LEU A 113
VAL A 174
VAL A 121
 None
 1.48A 4mjrA-5mswA:
undetectable		 4mjrA-5mswA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqd ARSENITE OXIDASE
LARGE SUBUNIT AIOA
[3FE-4S] CLUSTER,
MO-MOLYBDOPTERIN
COFACTOR-BINDING
ACTIVE SITE

(Rhizobium sp.
NT-26) 		no annotation 5 ARG A 506
TYR A 503
GLY A 479
LEU A 163
VAL A 155
 None
 1.47A 4mjrA-5nqdA:
undetectable		 4mjrA-5nqdA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7z DNA POLYMERASE III
SUBUNIT BETA

(Rickettsia
conorii) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		7 ARG A 152
THR A 172
GLY A 174
LEU A 177
PRO A 246
VAL A 373
MET A 375
 None
MRD  A 403 (-3.1A)
MRD  A 403 (-3.8A)
MRD  A 403 ( 4.0A)
None
MRD  A 403 ( 4.7A)
MRD  A 403 ( 4.5A)
 0.96A 4mjrA-5w7zA:
41.7		 4mjrA-5w7zA:
29.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wyp DNA POLYMERASE III
SUBUNIT BETA

(Caulobacter
vibrioides) 		no annotation 8 TYR A 154
THR A 177
GLY A 179
LEU A 182
PRO A 248
VAL A 253
VAL A 366
MET A 368
 None
 1.04A 4mjrA-5wypA:
42.0		 4mjrA-5wypA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wyp DNA POLYMERASE III
SUBUNIT BETA

(Caulobacter
vibrioides) 		no annotation 6 TYR A 155
THR A 177
GLY A 179
LEU A 182
VAL A 253
VAL A 366
 None
 0.63A 4mjrA-5wypA:
42.0		 4mjrA-5wypA:
13.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6ams BETA SLIDING CLAMP

(Pseudomonas
aeruginosa) 		no annotation 8 ARG A 152
TYR A 154
THR A 172
GLY A 174
LEU A 177
PRO A 243
VAL A 248
VAL A 361
 None
 0.64A 4mjrA-6amsA:
46.4		 4mjrA-6amsA:
55.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6ams BETA SLIDING CLAMP

(Pseudomonas
aeruginosa) 		no annotation 6 THR A 172
LEU A 177
PRO A 243
VAL A 248
VAL A 361
MET A 363
 None
 0.77A 4mjrA-6amsA:
46.4		 4mjrA-6amsA:
55.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ap4 DNA POLYMERASE III
SUBUNIT BETA

(Acinetobacter
baumannii) 		no annotation 8 ARG A 156
TYR A 158
THR A 176
GLY A 178
LEU A 181
PRO A 258
VAL A 263
VAL A 376
 None
 0.55A 4mjrA-6ap4A:
43.4		 4mjrA-6ap4A:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ap4 DNA POLYMERASE III
SUBUNIT BETA

(Acinetobacter
baumannii) 		no annotation 8 ARG A 156
TYR A 158
THR A 176
LEU A 181
PRO A 258
VAL A 263
VAL A 376
MET A 378
 None
 0.91A 4mjrA-6ap4A:
43.4		 4mjrA-6ap4A:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btm ALTERNATIVE COMPLEX
III SUBUNIT C

(Flavobacterium
johnsoniae) 		no annotation 5 ARG C 458
GLY C 449
LEU C 447
VAL C  14
VAL C 443
 None
 1.04A 4mjrA-6btmC:
undetectable		 4mjrA-6btmC:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byf TYROSINE-PROTEIN
PHOSPHATASE SIW14

(Saccharomyces
cerevisiae) 		no annotation 5 TYR A 243
THR A 221
GLY A 217
LEU A 155
VAL A 154
 None
None
CIT  A 301 (-4.0A)
None
None
 1.44A 4mjrA-6byfA:
undetectable		 4mjrA-6byfA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d46 BETA SLIDING CLAMP

(Rickettsia
typhi) 		no annotation 6 THR A 172
GLY A 174
LEU A 177
PRO A 246
VAL A 375
MET A 377
 None
 0.65A 4mjrA-6d46A:
42.4		 4mjrA-6d46A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6deg BETA SLIDING CLAMP

(Bartonella
birtlesii) 		no annotation 5 THR A 177
GLY A 179
LEU A 182
VAL A 367
MET A 369
 None
 0.74A 4mjrA-6degA:
37.8		 4mjrA-6degA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6deg BETA SLIDING CLAMP

(Bartonella
birtlesii) 		no annotation 5 THR A 177
LEU A 182
VAL A 254
VAL A 367
MET A 369
 None
 0.77A 4mjrA-6degA:
37.8		 4mjrA-6degA:
12.40