SIMILAR PATTERNS OF AMINO ACIDS FOR 4MJQ_A_27RA401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1euf DUODENASE

(Bos taurus) 		PF00089
(Trypsin) 		4 ARG A  27
TYR A  29
PRO A 198
VAL A 213
 None
 1.48A 4mjqA-1eufA:
0.2		 4mjqA-1eufA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1foh PHENOL HYDROXYLASE

(Cutaneotrichosporon
cutaneum) 		PF01494
(FAD_binding_3)
PF07976
(Phe_hydrox_dim) 		4 ARG A  59
TYR A 623
THR A 506
VAL A  25
 None
 1.46A 4mjqA-1fohA:
0.6		 4mjqA-1fohA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fq3 GRANZYME B

(Homo sapiens) 		PF00089
(Trypsin) 		4 ARG A  27
TYR A  29
PRO A 198
VAL A 213
 None
 1.49A 4mjqA-1fq3A:
0.0		 4mjqA-1fq3A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5x SURVIVAL PROTEIN E

(Pyrobaculum
aerophilum) 		PF01975
(SurE) 		4 ARG A 257
TYR A 155
PRO A 162
VAL A 250
 None
None
None
ACY  A 401 (-4.3A)
 1.46A 4mjqA-1l5xA:
undetectable		 4mjqA-1l5xA:
26.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n26 IL-6 RECEPTOR ALPHA
CHAIN

(Homo sapiens) 		PF00047
(ig)
PF09240
(IL6Ra-bind) 		4 TYR A 148
THR A 125
PRO A 121
VAL A  93
 None
 1.48A 4mjqA-1n26A:
undetectable		 4mjqA-1n26A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 ARG A 231
TYR A 233
PRO A 197
VAL A 158
 None
 1.45A 4mjqA-1s9iA:
0.0		 4mjqA-1s9iA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v2a GLUTATHIONE
TRANSFERASE GST1-6

(Anopheles dirus) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		4 TYR A 104
THR A 162
PRO A  10
VAL A 198
 None
 1.29A 4mjqA-1v2aA:
undetectable		 4mjqA-1v2aA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ejc PANTOATE--BETA-ALANI
NE LIGASE

(Thermotoga
maritima) 		PF02569
(Pantoate_ligase) 		4 ARG A 187
TYR A 190
PRO A  72
VAL A  57
 None
 1.45A 4mjqA-2ejcA:
0.0		 4mjqA-2ejcA:
22.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3f1v DNA POLYMERASE III
SUBUNIT BETA

(Escherichia
coli) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		4 TYR A 154
THR A 172
PRO A 242
VAL A 247
 None
 1.23A 4mjqA-3f1vA:
49.3		 4mjqA-3f1vA:
98.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g01 GRANZYME C

(Mus musculus) 		PF00089
(Trypsin) 		4 ARG A  32
TYR A  34
PRO A 207
VAL A 218
 None
 1.48A 4mjqA-3g01A:
undetectable		 4mjqA-3g01A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 3

(Thermus
thermophilus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
PF10588
(NADH-G_4Fe-4S_3)
PF13510
(Fer2_4) 		4 ARG 3 695
TYR 3 454
THR 3 403
PRO 3 457
 None
 1.35A 4mjqA-3i9v3:
undetectable		 4mjqA-3i9v3:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rj8 CARBOHYDRATE OXIDASE

(Microdochium
nivale) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 ARG A 125
TYR A  97
THR A 101
VAL A 161
 None
 1.41A 4mjqA-3rj8A:
undetectable		 4mjqA-3rj8A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rp2 RAT MAST CELL
PROTEASE II

(Rattus rattus) 		PF00089
(Trypsin) 		4 ARG A  27
TYR A  29
PRO A 198
VAL A 213
 None
 1.49A 4mjqA-3rp2A:
undetectable		 4mjqA-3rp2A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bkw ZINC FINGER FYVE
DOMAIN-CONTAINING
PROTEIN 9

(Homo sapiens) 		PF11979
(DUF3480) 		4 TYR A1085
THR A1039
PRO A1086
VAL A1036
 None
 1.31A 4mjqA-4bkwA:
undetectable		 4mjqA-4bkwA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccd GALACTOCEREBROSIDASE

(Mus musculus) 		PF02057
(Glyco_hydro_59)
PF17387
(Glyco_hydro_59M) 		4 ARG A  53
TYR A 113
PRO A  98
VAL A 516
 None
 1.18A 4mjqA-4ccdA:
0.0		 4mjqA-4ccdA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cj0 ENDOGLUCANASE D

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		4 TYR A 168
THR A 145
PRO A 530
VAL A 504
 None
 1.41A 4mjqA-4cj0A:
undetectable		 4mjqA-4cj0A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwg UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Rickettsia
bellii) 		PF02350
(Epimerase_2) 		4 ARG A 151
TYR A 152
THR A 146
PRO A 306
 None
 1.48A 4mjqA-4hwgA:
undetectable		 4mjqA-4hwgA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jmo CYTOHESIN-2

(Homo sapiens) 		PF01369
(Sec7) 		4 ARG A 239
TYR A 235
PRO A 208
VAL A 204
 None
 1.48A 4mjqA-4jmoA:
undetectable		 4mjqA-4jmoA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4luj OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Methanocaldococcus
jannaschii) 		PF00215
(OMPdecase) 		4 ARG A 171
THR A 132
PRO A 165
VAL A 183
 None
 1.19A 4mjqA-4lujA:
undetectable		 4mjqA-4lujA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ra7 PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE

(Atopobium
parvulum) 		PF00905
(Transpeptidase) 		4 ARG A 552
TYR A 554
THR A 538
PRO A 555
 None
 1.33A 4mjqA-4ra7A:
undetectable		 4mjqA-4ra7A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aju PHOSPHORIBOHYDROLASE
LONELY GUY

(Claviceps
purpurea) 		PF03641
(Lysine_decarbox) 		4 ARG A  96
THR A  66
PRO A 114
VAL A 118
 SO4  A1242 (-2.6A)
None
None
None
 1.23A 4mjqA-5ajuA:
undetectable		 4mjqA-5ajuA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5efr BAMA-BAMD FUSION
PROTEIN

(Rhodothermus
marinus) 		PF07244
(POTRA)
PF13525
(YfiO) 		4 ARG A 408
TYR A1177
THR A 393
PRO A 415
 None
 1.44A 4mjqA-5efrA:
undetectable		 4mjqA-5efrA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5inf CARBOXYL TRANSFERASE

(Streptomyces
ambofaciens) 		PF01039
(Carboxyl_trans) 		4 ARG A 415
TYR A 297
PRO A 342
VAL A 348
 None
 1.42A 4mjqA-5infA:
undetectable		 4mjqA-5infA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iww PLS9-PPR

(unidentified) 		PF12854
(PPR_1)
PF13041
(PPR_2) 		4 TYR D  77
THR D  54
PRO D  50
VAL D  17
 None
 1.21A 4mjqA-5iwwD:
undetectable		 4mjqA-5iwwD:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opt 40S RIBOSOMAL
PROTEIN S4
40S RIBOSOMAL
PROTEIN S6

(Trypanosoma
cruzi) 		no annotation 4 TYR P 212
THR L 151
PRO L 147
VAL L 123
 None
 1.44A 4mjqA-5optP:
undetectable		 4mjqA-5optP:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5whz ANTI-HIV CODV-FAB
HEAVY CHAIN
ANTI-HIV CODV-FAB
LIGHT CHAIN

(Homo sapiens) 		no annotation 4 TYR H  95
THR H  93
PRO H  41
VAL L  89
 None
 0.96A 4mjqA-5whzH:
undetectable		 4mjqA-5whzH:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wyp DNA POLYMERASE III
SUBUNIT BETA

(Caulobacter
vibrioides) 		no annotation 4 TYR A 154
THR A 177
PRO A 248
VAL A 253
 None
 1.16A 4mjqA-5wypA:
42.2		 4mjqA-5wypA:
13.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6ams BETA SLIDING CLAMP

(Pseudomonas
aeruginosa) 		no annotation 5 ARG A 152
TYR A 154
THR A 172
PRO A 243
VAL A 248
 None
 0.79A 4mjqA-6amsA:
45.8		 4mjqA-6amsA:
55.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ap4 DNA POLYMERASE III
SUBUNIT BETA

(Acinetobacter
baumannii) 		no annotation 5 ARG A 156
TYR A 158
THR A 176
PRO A 258
VAL A 263
 None
 0.65A 4mjqA-6ap4A:
43.5		 4mjqA-6ap4A:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F

(Pyrococcus
furiosus) 		no annotation 4 ARG B  54
TYR B  57
PRO D  63
VAL E  60
 None
 1.41A 4mjqA-6cfwB:
undetectable		 4mjqA-6cfwB:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f71 GLUTATHIONE
TRANSFERASE

(Trametes
versicolor) 		no annotation 4 ARG A  54
TYR A  51
PRO A  81
VAL A  85
 None
 1.16A 4mjqA-6f71A:
undetectable		 4mjqA-6f71A:
11.83