SIMILAR PATTERNS OF AMINO ACIDS FOR 4MJ8_A_SPMA202

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d8c MALATE SYNTHASE G

(Escherichia
coli) 		PF01274
(Malate_synthase) 		4 ILE A 260
GLU A 239
GLN A 241
ILE A 242
 SO4  A8000 (-3.9A)
SO4  A8000 ( 4.7A)
SO4  A8000 (-3.6A)
None
 0.79A 4mj8A-1d8cA:
undetectable		 4mj8A-1d8cA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dll TETANUS TOXIN

(Clostridium
tetani) 		PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N) 		4 GLU A 973
GLN A1013
ILE A1014
LEU A1004
 None
 0.86A 4mj8A-1dllA:
undetectable		 4mj8A-1dllA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f5j BETA-1,4-XYLANASE

(Dictyoglomus
thermophilum) 		PF00457
(Glyco_hydro_11) 		4 GLU A  16
ILE A 131
GLN A 174
ILE A 175
 None
 0.88A 4mj8A-1f5jA:
undetectable		 4mj8A-1f5jA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f76 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)

(Escherichia
coli) 		PF01180
(DHO_dh) 		4 GLU A  83
ILE A 293
GLN A 316
ILE A 317
 None
 0.92A 4mj8A-1f76A:
0.3		 4mj8A-1f76A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jv1 GLCNAC1P
URIDYLTRANSFERASE
ISOFORM 1: AGX1

(Homo sapiens) 		PF01704
(UDPGP) 		4 ILE A 269
GLU A  93
GLN A  97
ILE A  98
 None
 0.70A 4mj8A-1jv1A:
undetectable		 4mj8A-1jv1A:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mdf 2,3-DIHYDROXYBENZOAT
E-AMP LIGASE

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ILE A 414
GLU A 426
GLN A 432
ILE A 433
 None
 0.90A 4mj8A-1mdfA:
0.6		 4mj8A-1mdfA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxi CONSERVED
HYPOTHETICAL PROTEIN
VC0424

(Vibrio cholerae) 		PF06877
(RraB) 		4 ILE A  16
GLU A  20
GLN A  17
ILE A  97
 None
 0.90A 4mj8A-1nxiA:
undetectable		 4mj8A-1nxiA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxu HYPOTHETICAL
OXIDOREDUCTASE YIAK

(Escherichia
coli) 		PF02615
(Ldh_2) 		4 ILE A  98
GLU A  99
ILE A 135
LEU A 108
 None
 0.91A 4mj8A-1nxuA:
undetectable		 4mj8A-1nxuA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ppq COMPLEMENT RECEPTOR
TYPE 1

(Homo sapiens) 		PF00084
(Sushi) 		4 ILE A1023
GLN A1021
ILE A1019
LEU A 996
 None
 0.76A 4mj8A-1ppqA:
undetectable		 4mj8A-1ppqA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rc9 CYSTEINE-RICH
SECRETORY PROTEIN

(Trimeresurus
stejnegeri) 		PF00188
(CAP)
PF08562
(Crisp) 		4 ILE A  14
GLU A  13
GLU A  17
LEU A  21
 None
 0.81A 4mj8A-1rc9A:
undetectable		 4mj8A-1rc9A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txu RAB5 GDP/GTP
EXCHANGE FACTOR

(Homo sapiens) 		PF02204
(VPS9) 		4 GLU A 232
GLN A 239
ILE A 242
LEU A 331
 GLU  A 232 ( 0.5A)
GLN  A 239 ( 0.6A)
ILE  A 242 ( 0.7A)
LEU  A 331 ( 0.6A)
 0.76A 4mj8A-1txuA:
undetectable		 4mj8A-1txuA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjv UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 6

(Saccharomyces
cerevisiae) 		PF00443
(UCH) 		4 ILE A 162
GLU A 163
GLN A 159
ILE A 156
 None
 0.76A 4mj8A-1vjvA:
undetectable		 4mj8A-1vjvA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vl4 PMBA-RELATED PROTEIN

(Thermotoga
maritima) 		PF01523
(PmbA_TldD) 		4 ILE A 240
GLU A 237
ILE A 421
LEU A 233
 None
 0.93A 4mj8A-1vl4A:
undetectable		 4mj8A-1vl4A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wpw 3-ISOPROPYLMALATE
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00180
(Iso_dh) 		4 ILE A  38
GLU A  36
ILE A   7
LEU A  69
 None
 0.89A 4mj8A-1wpwA:
undetectable		 4mj8A-1wpwA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xt0 GUANINE NUCLEOTIDE
EXCHANGE PROTEIN

(Legionella
pneumophila) 		PF01369
(Sec7) 		4 GLU B  11
ILE B  30
GLU B   4
ILE B  24
 None
 0.92A 4mj8A-1xt0B:
undetectable		 4mj8A-1xt0B:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yga HYPOTHETICAL 37.9
KDA PROTEIN IN
BIO3-HXT17
INTERGENIC REGION

(Saccharomyces
cerevisiae) 		PF01263
(Aldose_epim) 		4 GLU A 278
GLU A 152
GLN A 337
LEU A 155
 None
 0.94A 4mj8A-1ygaA:
undetectable		 4mj8A-1ygaA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aml SIS DOMAIN PROTEIN

(Listeria
monocytogenes) 		PF01380
(SIS) 		4 GLU A  12
ILE A 321
GLU A 229
LEU A 327
 None
 0.95A 4mj8A-2amlA:
undetectable		 4mj8A-2amlA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cja SERYL-TRNA
SYNTHETASE

(Methanosarcina
barkeri) 		no annotation 4 ILE A 102
GLU A 132
GLN A 130
ILE A 129
 None
 0.83A 4mj8A-2cjaA:
undetectable		 4mj8A-2cjaA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cyc TYROSYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00579
(tRNA-synt_1b) 		4 ILE A 246
GLU A 242
GLU A 245
GLN A 249
 None
 0.95A 4mj8A-2cycA:
undetectable		 4mj8A-2cycA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3t 3-KETOACYL-COA
THIOLASE

(Pseudomonas
fragi) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 GLU C 123
ILE C  72
GLU C  32
LEU C  38
 None
 0.86A 4mj8A-2d3tC:
undetectable		 4mj8A-2d3tC:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dry 29-KDA
GALACTOSE-BINDING
LECTIN

(Lumbricus
terrestris) 		PF00652
(Ricin_B_lectin) 		4 GLU A 196
GLU A 199
GLN A 197
ILE A 242
 None
 0.95A 4mj8A-2dryA:
undetectable		 4mj8A-2dryA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ea1 RIBONUCLEASE I

(Escherichia
coli) 		PF00445
(Ribonuclease_T2) 		4 GLU A 206
GLN A 208
ILE A 209
LEU A  18
 None
GPG  A 250 (-2.6A)
None
None
 0.87A 4mj8A-2ea1A:
undetectable		 4mj8A-2ea1A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqh KIAA1556 PROTEIN

(Homo sapiens) 		PF07679
(I-set) 		4 GLU A  62
GLN A  64
ILE A  65
LEU A  27
 None
 0.74A 4mj8A-2gqhA:
undetectable		 4mj8A-2gqhA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ldi ZINC-TRANSPORTING
ATPASE

(Synechocystis
sp. PCC 6803) 		PF00403
(HMA) 		4 ILE A  60
GLU A  59
GLN A  63
ILE A  66
 None
 0.88A 4mj8A-2ldiA:
undetectable		 4mj8A-2ldiA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lsl TELOMERASE
ASSOCIATED PROTEIN
P65

(Tetrahymena
thermophila) 		no annotation 4 GLU A 413
GLN A 461
ILE A 386
LEU A 457
 None
 0.68A 4mj8A-2lslA:
undetectable		 4mj8A-2lslA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oml RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE E

(Escherichia
coli) 		PF00849
(PseudoU_synth_2) 		4 GLU A 146
ILE A 157
GLN A 112
LEU A 194
 None
 0.76A 4mj8A-2omlA:
undetectable		 4mj8A-2omlA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2put ISOMERASE DOMAIN OF
GLUTAMINE-FRUCTOSE-6
-PHOSPHATE
TRANSAMINASE
(ISOMERIZING)

(Candida
albicans) 		PF01380
(SIS) 		4 GLU A 670
GLN A 545
ILE A 546
LEU A 678
 None
 0.91A 4mj8A-2putA:
undetectable		 4mj8A-2putA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1f CHONDROITINASE

(Bacteroides
thetaiotaomicron) 		PF02278
(Lyase_8)
PF09092
(Lyase_N)
PF09093
(Lyase_catalyt) 		4 GLU A 415
GLU A 221
ILE A 411
LEU A 220
 None
 0.94A 4mj8A-2q1fA:
undetectable		 4mj8A-2q1fA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r51 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 26B

(Mus musculus) 		PF03643
(Vps26) 		4 ILE A  71
GLU A  85
GLN A  73
ILE A  74
 None
 0.85A 4mj8A-2r51A:
undetectable		 4mj8A-2r51A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2waa XYLAN ESTERASE,
PUTATIVE, AXE2C

(Cellvibrio
japonicus) 		PF13472
(Lipase_GDSL_2) 		4 ILE A  68
GLU A 100
ILE A  65
LEU A  43
 None
 0.91A 4mj8A-2waaA:
undetectable		 4mj8A-2waaA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bt5 UNCHARACTERIZED
PROTEIN DUF305

(Deinococcus
radiodurans) 		PF03713
(DUF305) 		4 GLU A  56
GLN A  71
ILE A  70
LEU A  50
 None
 0.89A 4mj8A-3bt5A:
undetectable		 4mj8A-3bt5A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c6g CYTOCHROME P450 2R1

(Homo sapiens) 		PF00067
(p450) 		5 GLU A 313
GLU A 216
GLU A 219
GLN A 490
LEU A 485
 None
 1.49A 4mj8A-3c6gA:
undetectable		 4mj8A-3c6gA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cew UNCHARACTERIZED
CUPIN PROTEIN

(Bacteroides
fragilis) 		PF07883
(Cupin_2) 		4 TRP A  75
ILE A  51
GLU A  49
ILE A  54
 None
 0.94A 4mj8A-3cewA:
undetectable		 4mj8A-3cewA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT

(Methanosarcina
barkeri) 		PF03063
(Prismane) 		4 ILE A 616
GLU A 615
ILE A 650
LEU A 621
 None
 0.91A 4mj8A-3cf4A:
undetectable		 4mj8A-3cf4A:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwi CYSTEINE SYNTHASE B

(Mycobacterium
tuberculosis) 		PF00291
(PALP) 		4 ILE A 120
GLU A 114
ILE A  84
LEU A 115
 None
 0.94A 4mj8A-3dwiA:
undetectable		 4mj8A-3dwiA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3glb HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CATM

(Acinetobacter
sp. ADP1) 		PF03466
(LysR_substrate) 		4 ILE A 227
GLU A 226
ILE A 242
LEU A 194
 CCU  A   3 ( 3.7A)
None
None
None
 0.85A 4mj8A-3glbA:
undetectable		 4mj8A-3glbA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iie 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Yersinia
pseudotuberculosis) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		4 GLU A 371
ILE A 381
ILE A 129
LEU A 335
 None
 0.89A 4mj8A-3iieA:
undetectable		 4mj8A-3iieA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k0w MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1, ISOFORM 2

(Homo sapiens) 		PF13895
(Ig_2)
PF13927
(Ig_3) 		4 GLU A 224
GLN A 228
ILE A 229
LEU A 227
 None
 0.85A 4mj8A-3k0wA:
undetectable		 4mj8A-3k0wA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kex RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLU A 687
ILE A 722
GLN A 765
ILE A 725
LEU A 758
 None
 1.47A 4mj8A-3kexA:
undetectable		 4mj8A-3kexA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lnb N-ACETYLTRANSFERASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF00797
(Acetyltransf_2) 		4 ILE A  51
GLU A  71
GLN A 205
LEU A  68
 None
None
None
COA  A1001 ( 4.4A)
 0.86A 4mj8A-3lnbA:
undetectable		 4mj8A-3lnbA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rk6 POLYADENYLATE-BINDIN
G
PROTEIN-INTERACTING
PROTEIN 1

(Homo sapiens) 		PF02854
(MIF4G) 		4 ILE A 132
GLN A 128
ILE A 125
LEU A  90
 None
 0.92A 4mj8A-3rk6A:
undetectable		 4mj8A-3rk6A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ruy ORNITHINE
AMINOTRANSFERASE

(Bacillus
anthracis) 		PF00202
(Aminotran_3) 		5 GLU A 133
ILE A 183
GLU A 219
ILE A 191
LEU A 222
 None
 1.32A 4mj8A-3ruyA:
undetectable		 4mj8A-3ruyA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s95 LIM DOMAIN KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ILE A 354
GLU A 369
GLN A 352
LEU A 370
 None
 0.85A 4mj8A-3s95A:
undetectable		 4mj8A-3s95A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sky COPPER-EXPORTING
P-TYPE ATPASE B

(Archaeoglobus
fulgidus) 		PF00702
(Hydrolase) 		4 ILE A 529
GLU A 628
ILE A 626
LEU A 629
 None
 0.93A 4mj8A-3skyA:
undetectable		 4mj8A-3skyA:
20.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tth SPERMIDINE
N1-ACETYLTRANSFERASE

(Coxiella
burnetii) 		PF13302
(Acetyltransf_3) 		4 GLU A  77
GLU A  86
ILE A  89
LEU A 123
 None
 0.44A 4mj8A-3tthA:
22.8		 4mj8A-3tthA:
54.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wr7 SPERMIDINE
N1-ACETYLTRANSFERASE

(Escherichia
coli) 		PF13302
(Acetyltransf_3) 		7 TRP A  31
GLU A  33
GLU A  74
GLU A  83
GLN A  85
ILE A  86
LEU A 120
 COA  A 202 (-4.8A)
SPD  A 201 (-3.9A)
None
None
COA  A 202 ( 4.7A)
COA  A 202 (-4.1A)
COA  A 202 ( 4.6A)
 0.87A 4mj8A-3wr7A:
28.7		 4mj8A-3wr7A:
57.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zzu ELONGATION FACTOR G

(Staphylococcus
aureus) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		4 GLU A  93
GLU A 399
ILE A 288
LEU A 398
 None
 0.94A 4mj8A-3zzuA:
undetectable		 4mj8A-3zzuA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b86 MALE-SPECIFIC LETHAL
1 HOMOLOG

(Homo sapiens) 		PF16801
(MSL1_dimer) 		4 ILE A 247
GLU A 248
GLU A 244
LEU A 240
 None
 0.95A 4mj8A-4b86A:
undetectable		 4mj8A-4b86A:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cr2 26S PROTEASE
REGULATORY SUBUNIT 4
HOMOLOG

(Saccharomyces
cerevisiae) 		PF00004
(AAA) 		4 ILE I 302
GLU I 299
ILE I 284
LEU I 252
 None
 0.81A 4mj8A-4cr2I:
undetectable		 4mj8A-4cr2I:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f5x RNA-DIRECTED RNA
POLYMERASE

(Rotavirus A) 		PF02123
(RdRP_4)
PF12289
(Rotavirus_VP1) 		4 GLU W 593
ILE W 538
GLN W 565
ILE W 566
 None
 0.82A 4mj8A-4f5xW:
undetectable		 4mj8A-4f5xW:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1

(Saccharomyces
cerevisiae) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 ILE A 224
GLU A 382
GLN A 222
LEU A 383
 None
 0.86A 4mj8A-4g1pA:
undetectable		 4mj8A-4g1pA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hfu HEMAGGLUTININ HA1

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 GLU A  60
GLU A 275
ILE A  56
LEU A  53
 None
 0.95A 4mj8A-4hfuA:
undetectable		 4mj8A-4hfuA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3h TOPOISOMERASE IV
SUBUNIT B, DNA
TOPOISOMERASE 4
SUBUNIT A CHIMERA

(Streptococcus
pneumoniae) 		PF00204
(DNA_gyraseB)
PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
PF02518
(HATPase_c) 		5 GLU A1290
GLU A1301
GLN A1253
ILE A1244
LEU A1302
 None
 1.12A 4mj8A-4i3hA:
undetectable		 4mj8A-4i3hA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4it1 PUTATIVE GLUCARATE
DEHYDRATASE

(Pseudomonas
fluorescens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A  43
GLU A  37
GLU A  35
ILE A 360
 None
 0.92A 4mj8A-4it1A:
undetectable		 4mj8A-4it1A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k25 PROBABLE TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN QRI7,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00814
(Peptidase_M22) 		4 GLU A 293
ILE A 224
GLU A 221
ILE A 287
 None
 0.95A 4mj8A-4k25A:
undetectable		 4mj8A-4k25A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf5 FLUORESCENT PROTEIN
SFCHERRY+GFP10-11

(synthetic
construct) 		PF01353
(GFP) 		4 TRP C 143
ILE C 161
GLU C 148
GLN C 163
 CH6  C  66 ( 4.7A)
CH6  C  66 ( 4.9A)
None
CH6  C  66 ( 3.5A)
 0.93A 4mj8A-4kf5C:
undetectable		 4mj8A-4kf5C:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4knh NUP192P

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		4 GLU A 146
GLN A 153
ILE A 142
LEU A 152
 None
 0.89A 4mj8A-4knhA:
undetectable		 4mj8A-4knhA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvs ALDEHYDE
DECARBONYLASE

(Prochlorococcus
marinus) 		PF11266
(Ald_deCOase) 		4 ILE A 127
GLU A 128
GLN A 123
ILE A  55
 6NA  A 301 (-4.8A)
FE  A 303 ( 1.9A)
6NA  A 301 (-4.0A)
None
 0.92A 4mj8A-4kvsA:
undetectable		 4mj8A-4kvsA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mad BETA-GALACTOSIDASE

(Bacillus
circulans) 		PF01301
(Glyco_hydro_35) 		4 ILE A  88
GLU A  50
ILE A  17
LEU A  20
 None
 0.91A 4mj8A-4madA:
undetectable		 4mj8A-4madA:
15.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mi4 SPERMIDINE
N1-ACETYLTRANSFERASE

(Vibrio cholerae) 		PF13302
(Acetyltransf_3) 		8 TRP A  31
GLU A  33
ILE A  74
GLU A  75
GLU A  84
GLN A  86
ILE A  87
LEU A 121
 None
SPM  A 201 (-3.2A)
None
None
None
None
None
None
 0.12A 4mj8A-4mi4A:
31.8		 4mj8A-4mi4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4npa PUTATIVE
UNCHARACTERIZED
PROTEIN

(Vibrio cholerae) 		PF03641
(Lysine_decarbox)
PF11892
(DUF3412)
PF14793
(DUF4478) 		4 ILE A 321
GLU A 295
ILE A 256
LEU A 301
 None
 0.74A 4mj8A-4npaA:
undetectable		 4mj8A-4npaA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4okm TERPENE SYNTHASE
METAL-BINDING
DOMAIN-CONTAINING
PROTEIN

(Streptomyces
pristinaespiralis) 		no annotation 4 GLU A 203
GLU A 198
GLU A 192
LEU A 191
 None
 0.78A 4mj8A-4okmA:
undetectable		 4mj8A-4okmA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q7o IMMUNITY PROTEIN

(Neisseria
meningitidis) 		no annotation 4 ILE A  28
GLU A  32
ILE A 112
LEU A  38
 None
 0.67A 4mj8A-4q7oA:
undetectable		 4mj8A-4q7oA:
27.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r33 NOSL

(Streptomyces
actuosus) 		PF06968
(BATS) 		4 ILE A 127
GLU A 132
GLN A 124
ILE A 121
 None
 0.95A 4mj8A-4r33A:
undetectable		 4mj8A-4r33A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT

(Aquincola
tertiaricarbonis) 		PF01642
(MM_CoA_mutase) 		4 ILE A 533
GLU A 534
ILE A 225
LEU A 528
 None
 0.93A 4mj8A-4r3uA:
undetectable		 4mj8A-4r3uA:
15.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r9m SPERMIDINE
N(1)-ACETYLTRANSFERA
SE

(Escherichia
coli) 		PF13302
(Acetyltransf_3) 		5 GLU A  76
GLU A  85
GLN A  87
ILE A  88
LEU A 122
 MG  A 201 (-2.9A)
None
None
None
None
 0.88A 4mj8A-4r9mA:
23.0		 4mj8A-4r9mA:
54.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9n LMO0547 PROTEIN

(Listeria
monocytogenes) 		PF04198
(Sugar-bind) 		4 ILE A  78
GLU A  76
GLU A  65
LEU A  64
 None
 0.90A 4mj8A-4r9nA:
undetectable		 4mj8A-4r9nA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rc6 ALDEHYDE
DECARBONYLASE

(Synechococcus
elongatus) 		PF11266
(Ald_deCOase) 		4 GLU B  60
ILE B 114
GLN B 110
LEU B 107
 FE2  B 301 ( 2.3A)
None
None
None
 0.84A 4mj8A-4rc6B:
undetectable		 4mj8A-4rc6B:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tlv ADP-RIBOSYLATING
TOXIN CARDS

(Mycoplasma
pneumoniae) 		PF02917
(Pertussis_S1) 		4 GLU A 416
GLU A 301
ILE A 420
LEU A 288
 None
 0.86A 4mj8A-4tlvA:
undetectable		 4mj8A-4tlvA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tlv ADP-RIBOSYLATING
TOXIN CARDS

(Mycoplasma
pneumoniae) 		PF02917
(Pertussis_S1) 		5 ILE A 280
GLU A 417
GLN A 419
ILE A 420
LEU A 390
 None
 0.78A 4mj8A-4tlvA:
undetectable		 4mj8A-4tlvA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upi SULFATASE FAMILY
PROTEIN

(Ruegeria
pomeroyi) 		PF00884
(Sulfatase) 		4 GLU A 199
GLU A 198
GLN A 304
ILE A 301
 None
 0.86A 4mj8A-4upiA:
undetectable		 4mj8A-4upiA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uxv SEPTATION RING
FORMATION REGULATOR
EZRA

(Bacillus
subtilis) 		PF06160
(EzrA) 		4 ILE A 119
GLU A 120
GLU A 116
LEU A 112
 None
 0.91A 4mj8A-4uxvA:
undetectable		 4mj8A-4uxvA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbd BSHC

(Bacillus
subtilis) 		PF10079
(BshC) 		4 TRP A 129
GLU A 133
ILE A 237
LEU A 229
 None
 0.64A 4mj8A-4wbdA:
undetectable		 4mj8A-4wbdA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x0r INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX2

(Homo sapiens) 		no annotation 4 ILE B  63
GLU B  66
GLU B  67
ILE B  91
 None
 0.87A 4mj8A-4x0rB:
undetectable		 4mj8A-4x0rB:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yv2 SPERMIDINE SYNTHASE,
PUTATIVE

(Trypanosoma
cruzi) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 ILE A 242
GLU A 203
GLN A 201
ILE A 167
 None
 0.92A 4mj8A-4yv2A:
2.3		 4mj8A-4yv2A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z3o DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE

(Streptococcus
pneumoniae) 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim) 		4 GLU A1290
GLU A1301
GLN A1253
ILE A1254
 None
 0.84A 4mj8A-4z3oA:
undetectable		 4mj8A-4z3oA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgv FERREDOXIN RECEPTOR

(Pectobacterium
atrosepticum) 		PF07715
(Plug) 		4 ILE A 293
GLU A 321
GLU A 291
GLN A 274
 None
 0.85A 4mj8A-4zgvA:
undetectable		 4mj8A-4zgvA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwq DESIGNED HELICAL
REPEAT PROTEIN

(synthetic
construct) 		no annotation 4 GLU A 212
ILE A  41
GLU A  38
LEU A  97
 GOL  A 301 (-2.8A)
GOL  A 301 ( 4.2A)
None
None
 0.89A 4mj8A-5cwqA:
undetectable		 4mj8A-5cwqA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eo9 DPR6, ISOFORM C

(Drosophila
melanogaster) 		PF07679
(I-set) 		4 ILE A 108
GLU A 156
GLN A 158
ILE A 159
 None
 0.82A 4mj8A-5eo9A:
undetectable		 4mj8A-5eo9A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gwj DNA TOPOISOMERASE
2-BETA

(Homo sapiens) 		PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF16898
(TOPRIM_C) 		4 GLU A 718
ILE A 590
GLN A 558
ILE A 593
 None
 0.86A 4mj8A-5gwjA:
undetectable		 4mj8A-5gwjA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hpk E3 UBIQUITIN-PROTEIN
LIGASE NEDD4-LIKE

(Homo sapiens) 		PF00632
(HECT) 		4 GLU A 786
ILE A 777
ILE A 757
LEU A 753
 None
 0.79A 4mj8A-5hpkA:
undetectable		 4mj8A-5hpkA:
16.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ix3 DIAMINE
N-ACETYLTRANSFERASE

(Staphylococcus
aureus) 		PF13302
(Acetyltransf_3) 		5 GLU A  70
GLU A  79
GLN A  81
ILE A  82
LEU A 116
 None
 0.78A 4mj8A-5ix3A:
23.0		 4mj8A-5ix3A:
54.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE

([Candida]
glabrata) 		PF00067
(p450) 		4 GLU A  82
GLU A 418
GLU A 419
GLN A 417
 None
 0.91A 4mj8A-5jlcA:
undetectable		 4mj8A-5jlcA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jwf ASP/GLU-SPECIFIC
DIPEPTIDYL-PEPTIDASE

(Porphyromonas
gingivalis) 		PF10459
(Peptidase_S46) 		4 TRP A 395
GLU A 287
GLU A 290
ILE A 298
 None
 0.88A 4mj8A-5jwfA:
undetectable		 4mj8A-5jwfA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kgq UNCHARACTERIZED
PROTEIN

(Trypanosoma
cruzi) 		no annotation 4 GLU A  94
GLU A 100
GLU A 105
ILE A  18
 None
 0.91A 4mj8A-5kgqA:
undetectable		 4mj8A-5kgqA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kgq UNCHARACTERIZED
PROTEIN

(Trypanosoma
cruzi) 		no annotation 4 ILE A 101
GLU A 100
GLU A 105
ILE A  18
 None
 0.95A 4mj8A-5kgqA:
undetectable		 4mj8A-5kgqA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m1m MATRIX PROTEIN 1

(Influenza C
virus) 		PF03026
(CM1) 		4 GLU A 108
ILE A   5
GLU A   9
ILE A 144
 None
 0.86A 4mj8A-5m1mA:
undetectable		 4mj8A-5m1mA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m1t MUCR
PHOSPHODIESTERASE

(Pseudomonas
aeruginosa) 		PF00563
(EAL) 		4 GLU A 678
GLN A 511
ILE A 525
LEU A 452
 None
 0.91A 4mj8A-5m1tA:
undetectable		 4mj8A-5m1tA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m2d ENDOGLUCANASE-LIKE
PROTEIN

(Acremonium
chrysogenum) 		no annotation 4 GLU A 207
GLU A 123
ILE A 126
LEU A 107
 None
 0.93A 4mj8A-5m2dA:
undetectable		 4mj8A-5m2dA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n0c TETANUS TOXIN

(Clostridium
tetani) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		4 GLU A 973
GLN A1013
ILE A1014
LEU A1004
 None
 0.80A 4mj8A-5n0cA:
undetectable		 4mj8A-5n0cA:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oj2 MAM
DOMAIN-CONTAINING
GLYCOSYLPHOSPHATIDYL
INOSITOL ANCHOR
PROTEIN 1

(Gallus gallus) 		PF13927
(Ig_3) 		4 ILE A 653
GLU A 699
GLN A 655
LEU A 698
 None
 0.91A 4mj8A-5oj2A:
undetectable		 4mj8A-5oj2A:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t58 KLLA0C15939P
KLLA0D15741P

(Kluyveromyces
lactis) 		PF08202
(MIS13)
PF08641
(Mis14) 		4 GLU N  39
ILE D 366
GLN N  45
ILE N  47
 None
 0.88A 4mj8A-5t58N:
undetectable		 4mj8A-5t58N:
21.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ug4 SPERMIDINE
N(1)-ACETYLTRANSFERA
SE

(Vibrio cholerae) 		PF13302
(Acetyltransf_3) 		6 ILE A  74
GLU A  75
GLU A  84
GLN A  86
ILE A  87
LEU A 121
 None
CA  A 201 (-3.5A)
None
None
None
None
 0.45A 4mj8A-5ug4A:
25.8		 4mj8A-5ug4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vj4 UNCHARACTERIZED
PROTEIN

(Borrelia
turicatae) 		no annotation 4 ILE A 360
GLU A 364
GLU A 361
ILE A 354
 None
None
None
SO4  A 505 ( 4.7A)
 0.87A 4mj8A-5vj4A:
undetectable		 4mj8A-5vj4A:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wtk CRISPR-ASSOCIATED
ENDORIBONUCLEASE
C2C2

(Leptotrichia
shahii) 		no annotation 4 ILE A 855
GLU A 517
ILE A 519
LEU A 516
 None
 0.93A 4mj8A-5wtkA:
undetectable		 4mj8A-5wtkA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbp 3NT OXYGENASE BETA
SUBUNIT

(Diaphorobacter
sp. DS2) 		PF00866
(Ring_hydroxyl_B) 		4 GLU C  54
GLN C 171
ILE C 170
LEU C 172
 None
 0.84A 4mj8A-5xbpC:
undetectable		 4mj8A-5xbpC:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yu8 COFILIN-2

(Gallus gallus) 		no annotation 4 GLU H  51
GLN H  54
ILE H  55
LEU H  37
 None
 0.92A 4mj8A-5yu8H:
undetectable		 4mj8A-5yu8H:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b9x HEPATITIS B VIRUS X
INTERACTING PROTEIN
RAGULATOR COMPLEX
PROTEIN LAMTOR1

(Homo sapiens) 		no annotation 4 ILE A 124
GLU E 150
ILE E 158
LEU E 149
 None
 0.95A 4mj8A-6b9xA:
undetectable		 4mj8A-6b9xA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cgm RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Bacillus
subtilis) 		no annotation 4 GLU A 426
GLU A 505
GLN A 501
ILE A 500
 None
 0.83A 4mj8A-6cgmA:
undetectable		 4mj8A-6cgmA:
20.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6d72 SPERMIDINE
N1-ACETYLTRANSFERASE

(Yersinia pestis) 		no annotation 4 GLU A  76
GLU A  85
ILE A  88
LEU A 122
 CA  A 201 ( 2.4A)
MLI  A 204 ( 4.6A)
None
None
 0.58A 4mj8A-6d72A:
23.3		 4mj8A-6d72A:
62.96