SIMILAR PATTERNS OF AMINO ACIDS FOR 4MJ8_A_SPMA201_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ajz DIHYDROPTEROATE
SYNTHASE

(Escherichia
coli) 		PF00809
(Pterin_bind) 		4 ASN A 162
GLU A 167
TYR A 164
GLU A 160
 None
 1.17A 4mj8A-1ajzA:
0.6
4mj8C-1ajzA:
0.8		 4mj8A-1ajzA:
22.46
4mj8C-1ajzA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bqb PROTEIN (AUREOLYSIN)

(Staphylococcus
aureus) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		4 MET A 122
GLU A 145
TYR A  73
TYR A 190
 None
ZN  A 350 ( 4.6A)
None
None
 1.14A 4mj8A-1bqbA:
0.0
4mj8C-1bqbA:
0.0		 4mj8A-1bqbA:
19.27
4mj8C-1bqbA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bt4 PHOSPHOSERINE
AMINOTRANSFERASE

(Bacillus
circulans) 		PF00266
(Aminotran_5) 		4 ASN A 127
GLU A 124
GLU A 155
TYR A  97
 None
 1.14A 4mj8A-1bt4A:
undetectable
4mj8C-1bt4A:
0.0		 4mj8A-1bt4A:
20.49
4mj8C-1bt4A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c2o ACETYLCHOLINESTERASE

(Electrophorus
electricus) 		PF00135
(COesterase) 		4 ASN A 514
GLU A 519
TYR A 428
GLU A 431
 None
 1.03A 4mj8A-1c2oA:
0.0
4mj8C-1c2oA:
1.4		 4mj8A-1c2oA:
13.79
4mj8C-1c2oA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF03173
(CHB_HEX)
PF03174
(CHB_HEX_C) 		5 ASN A 719
GLU A 782
GLU A 708
TYR A 778
GLU A 777
 None
 1.27A 4mj8A-1c7tA:
0.1
4mj8C-1c7tA:
undetectable		 4mj8A-1c7tA:
11.10
4mj8C-1c7tA:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1inp INOSITOL
POLYPHOSPHATE
1-PHOSPHATASE

(Bos taurus) 		PF00459
(Inositol_P) 		4 GLU A  38
GLU A  40
GLU A  79
GLU A  80
 None
None
MG  A 402 ( 3.1A)
None
 1.14A 4mj8A-1inpA:
0.2
4mj8C-1inpA:
0.1		 4mj8A-1inpA:
19.06
4mj8C-1inpA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1irx LYSYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF01921
(tRNA-synt_1f) 		4 ASN A 325
GLU A 331
TYR A 327
TYR A 337
 None
 1.16A 4mj8A-1irxA:
0.2
4mj8C-1irxA:
0.2		 4mj8A-1irxA:
16.63
4mj8C-1irxA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1npc NEUTRAL PROTEASE

(Bacillus cereus) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		4 MET A 121
GLU A 144
TYR A  77
TYR A 194
 None
ZN  A 323 ( 4.5A)
None
None
 1.09A 4mj8A-1npcA:
undetectable
4mj8C-1npcA:
undetectable		 4mj8A-1npcA:
17.43
4mj8C-1npcA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pii N-(5'PHOSPHORIBOSYL)
ANTHRANILATE
ISOMERASE

(Escherichia
coli) 		PF00218
(IGPS)
PF00697
(PRAI) 		4 GLU A  53
GLU A 214
GLU A 163
TYR A  92
 None
 1.11A 4mj8A-1piiA:
0.0
4mj8C-1piiA:
1.1		 4mj8A-1piiA:
15.38
4mj8C-1piiA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1px8 BETA-XYLOSIDASE

(Thermoanaerobacterium
saccharolyticum) 		PF01229
(Glyco_hydro_39) 		4 GLU A  99
GLU A 160
GLU A 323
TYR A 278
 None
XYP  A 601 (-2.2A)
XYP  A 601 (-2.6A)
None
 0.85A 4mj8A-1px8A:
undetectable
4mj8C-1px8A:
1.2		 4mj8A-1px8A:
17.04
4mj8C-1px8A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rbl RIBULOSE 1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E (LARGE CHAIN)
RIBULOSE 1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E (SMALL CHAIN)

(Synechococcus
elongatus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N)
no annotation 		4 ASN A 420
GLU A 425
TYR M  17
TYR A 165
 None
 1.07A 4mj8A-1rblA:
undetectable
4mj8C-1rblA:
undetectable		 4mj8A-1rblA:
18.04
4mj8C-1rblA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rh1 COLICIN B

(Escherichia
coli) 		PF01024
(Colicin)
PF03515
(Cloacin) 		4 ASN A 303
GLU A 299
GLU A 301
TYR A 259
 None
 1.16A 4mj8A-1rh1A:
undetectable
4mj8C-1rh1A:
undetectable		 4mj8A-1rh1A:
15.55
4mj8C-1rh1A:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svd RIBULOSE
BISPHOSPHATE
CARBOXYLASE SMALL
CHAIN
RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E LARGE SUBUNIT

(Halothiobacillus
neapolitanus) 		PF00016
(RuBisCO_large)
PF00101
(RuBisCO_small)
PF02788
(RuBisCO_large_N) 		4 ASN A 413
GLU A 418
TYR M  18
TYR A 158
 None
 1.04A 4mj8A-1svdA:
undetectable
4mj8C-1svdA:
undetectable		 4mj8A-1svdA:
15.50
4mj8C-1svdA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w85 PYRUVATE
DEHYDROGENASE E1
COMPONENT, ALPHA
SUBUNIT

(Geobacillus
stearothermophilus) 		PF00676
(E1_dh) 		4 MET A  50
GLU A 314
GLU A 313
GLU A 304
 None
 1.18A 4mj8A-1w85A:
undetectable
4mj8C-1w85A:
undetectable		 4mj8A-1w85A:
16.98
4mj8C-1w85A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zl9 GLUTATHIONE
S-TRANSFERASE 5

(Caenorhabditis
elegans) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 ASN A  32
GLU A  57
TYR A  29
GLU A  30
 None
 1.07A 4mj8A-1zl9A:
undetectable
4mj8C-1zl9A:
undetectable		 4mj8A-1zl9A:
21.50
4mj8C-1zl9A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bs9 BETA-XYLOSIDASE

(Geobacillus
stearothermophilus) 		PF01229
(Glyco_hydro_39) 		4 GLU A  99
GLU A 160
GLU A 324
TYR A 279
 None
 0.85A 4mj8A-2bs9A:
undetectable
4mj8C-2bs9A:
undetectable		 4mj8A-2bs9A:
18.98
4mj8C-2bs9A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1l RESTRICTION
ENDONUCLEASE

(Bacillus firmus) 		PF13091
(PLDc_2) 		4 ASN A 260
TYR A 312
GLU A 313
TYR A 330
 None
 1.18A 4mj8A-2c1lA:
undetectable
4mj8C-2c1lA:
undetectable		 4mj8A-2c1lA:
18.28
4mj8C-2c1lA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d9j REGULATOR OF
G-PROTEIN SIGNALLING
7

(Homo sapiens) 		PF00615
(RGS) 		4 ASN A  44
GLU A  39
GLU A  37
GLU A  43
 None
 1.17A 4mj8A-2d9jA:
undetectable
4mj8C-2d9jA:
undetectable		 4mj8A-2d9jA:
22.40
4mj8C-2d9jA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Mycobacterium
tuberculosis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 GLU A 198
GLU A 241
GLU A 202
GLU A 119
 None
 0.81A 4mj8A-2gp6A:
undetectable
4mj8C-2gp6A:
undetectable		 4mj8A-2gp6A:
17.40
4mj8C-2gp6A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kgy POSSIBLE EXPORTED
PROTEIN

(Mycobacterium
tuberculosis) 		no annotation 4 GLU A  31
GLU A  59
GLU A  82
TYR A  21
 None
 1.20A 4mj8A-2kgyA:
undetectable
4mj8C-2kgyA:
undetectable		 4mj8A-2kgyA:
18.50
4mj8C-2kgyA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l9c DARCIN

(Mus musculus) 		PF00061
(Lipocalin) 		4 ASN A 126
MET A  57
GLU A 137
TYR A  63
 None
 1.18A 4mj8A-2l9cA:
undetectable
4mj8C-2l9cA:
2.1		 4mj8A-2l9cA:
21.83
4mj8C-2l9cA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mk6 ADAPTER PROTEIN MECA

(Bacillus
subtilis) 		PF05389
(MecA) 		4 GLU A   4
GLU A  72
TYR A  14
GLU A   2
 None
 1.00A 4mj8A-2mk6A:
undetectable
4mj8C-2mk6A:
undetectable		 4mj8A-2mk6A:
22.03
4mj8C-2mk6A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mzw ELONGATION FACTOR G

(Staphylococcus
aureus) 		PF00679
(EFG_C)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		4 GLU A 517
GLU A 484
TYR A 557
TYR A 671
 None
 1.17A 4mj8A-2mzwA:
undetectable
4mj8C-2mzwA:
undetectable		 4mj8A-2mzwA:
20.00
4mj8C-2mzwA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pun METHYLTHIORIBOSE
KINASE

(Bacillus
subtilis) 		PF01636
(APH) 		4 ASN A 290
GLU A 283
TYR A 286
GLU A 389
 None
None
None
CPS  A 777 (-3.5A)
 0.99A 4mj8A-2punA:
undetectable
4mj8C-2punA:
undetectable		 4mj8A-2punA:
19.84
4mj8C-2punA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Staphylococcus
haemolyticus) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		4 GLU B 688
TYR B 579
GLU B 580
TYR B 685
 None
 0.96A 4mj8A-2rhqB:
undetectable
4mj8C-2rhqB:
undetectable		 4mj8A-2rhqB:
13.25
4mj8C-2rhqB:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vhh CG3027-PA

(Drosophila
melanogaster) 		PF00795
(CN_hydrolase) 		4 ASN A 145
GLU A 173
GLU A 169
GLU A 144
 None
 1.04A 4mj8A-2vhhA:
undetectable
4mj8C-2vhhA:
undetectable		 4mj8A-2vhhA:
17.49
4mj8C-2vhhA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wa0 MELANOMA-ASSOCIATED
ANTIGEN 4

(Homo sapiens) 		PF01454
(MAGE) 		4 GLU A 221
GLU A 219
TYR A 270
GLU A 271
 None
 1.04A 4mj8A-2wa0A:
undetectable
4mj8C-2wa0A:
undetectable		 4mj8A-2wa0A:
19.37
4mj8C-2wa0A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)

(Archaeoglobus
fulgidus) 		PF02492
(cobW) 		4 ASN A  34
MET A  36
TYR A 132
GLU A 130
 None
 1.23A 4mj8A-2wsmA:
undetectable
4mj8C-2wsmA:
undetectable		 4mj8A-2wsmA:
21.08
4mj8C-2wsmA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x24 ACETYL-COA
CARBOXYLASE

(Bos taurus) 		PF01039
(Carboxyl_trans) 		4 MET A  84
GLU A  72
GLU A  92
TYR A 135
 None
 1.19A 4mj8A-2x24A:
undetectable
4mj8C-2x24A:
undetectable		 4mj8A-2x24A:
12.11
4mj8C-2x24A:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x24 ACETYL-COA
CARBOXYLASE

(Bos taurus) 		PF01039
(Carboxyl_trans) 		4 MET A  84
GLU A  72
GLU A  92
TYR A 151
 None
 1.12A 4mj8A-2x24A:
undetectable
4mj8C-2x24A:
undetectable		 4mj8A-2x24A:
12.11
4mj8C-2x24A:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xom ARABINOGALACTAN
ENDO-1,4-BETA-GALACT
OSIDASE

(Thermotoga
maritima) 		no annotation 4 ASN A 133
GLU A 130
TYR A  88
GLU A 165
 None
 1.01A 4mj8A-2xomA:
undetectable
4mj8C-2xomA:
undetectable		 4mj8A-2xomA:
23.56
4mj8C-2xomA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xzi EXTRACELLULAR
SIALIDASE/NEURAMINID
ASE, PUTATIVE

(Aspergillus
fumigatus) 		PF13088
(BNR_2) 		4 GLU A 374
TYR A 358
GLU A  76
TYR A 387
 None
KDM  A 500 (-4.5A)
KDM  A 500 ( 4.7A)
None
 1.08A 4mj8A-2xziA:
undetectable
4mj8C-2xziA:
undetectable		 4mj8A-2xziA:
20.16
4mj8C-2xziA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yoc PULLULANASE

(Klebsiella
oxytoca) 		PF02922
(CBM_48)
PF03714
(PUD)
PF11852
(DUF3372) 		4 GLU A 475
GLU A 377
TYR A 378
GLU A 564
 CA  A2071 (-3.0A)
None
None
None
 1.14A 4mj8A-2yocA:
undetectable
4mj8C-2yocA:
undetectable		 4mj8A-2yocA:
9.55
4mj8C-2yocA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN

(Aeropyrum
pernix) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		4 GLU A 279
TYR A 240
GLU A 286
GLU A 282
 None
 1.22A 4mj8A-2yv2A:
undetectable
4mj8C-2yv2A:
undetectable		 4mj8A-2yv2A:
21.93
4mj8C-2yv2A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yvt HYPOTHETICAL PROTEIN
AQ_1956

(Aquifex
aeolicus) 		PF14582
(Metallophos_3) 		4 ASN A  99
GLU A 149
GLU A  49
GLU A  53
 None
 1.11A 4mj8A-2yvtA:
2.2
4mj8C-2yvtA:
2.1		 4mj8A-2yvtA:
23.60
4mj8C-2yvtA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yyy GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF01113
(DapB_N)
PF02800
(Gp_dh_C) 		4 ASN A  97
GLU A 115
TYR A 138
GLU A  99
 NAP  A2001 (-3.3A)
None
None
None
 1.13A 4mj8A-2yyyA:
undetectable
4mj8C-2yyyA:
undetectable		 4mj8A-2yyyA:
20.36
4mj8C-2yyyA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z61 PROBABLE ASPARTATE
AMINOTRANSFERASE 2

(Methanocaldococcus
jannaschii) 		PF00155
(Aminotran_1_2) 		4 ASN A 356
GLU A 281
TYR A 354
GLU A 355
 None
 1.04A 4mj8A-2z61A:
undetectable
4mj8C-2z61A:
undetectable		 4mj8A-2z61A:
21.47
4mj8C-2z61A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al0 ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B

(Thermotoga
maritima) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N) 		4 GLU B 234
GLU B 251
GLU B 249
TYR B   3
 None
 1.23A 4mj8A-3al0B:
undetectable
4mj8C-3al0B:
undetectable		 4mj8A-3al0B:
16.88
4mj8C-3al0B:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c37 PEPTIDASE, M48
FAMILY

(Geobacter
sulfurreducens) 		PF01435
(Peptidase_M48) 		4 ASN A 109
GLU A 162
TYR A 157
GLU A 107
 None
ZN  A 301 (-2.2A)
None
None
 1.11A 4mj8A-3c37A:
undetectable
4mj8C-3c37A:
undetectable		 4mj8A-3c37A:
17.86
4mj8C-3c37A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3a BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF01301
(Glyco_hydro_35) 		4 ASN A 232
GLU A 259
GLU A  48
TYR A 111
 None
 1.22A 4mj8A-3d3aA:
undetectable
4mj8C-3d3aA:
undetectable		 4mj8A-3d3aA:
14.90
4mj8C-3d3aA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3etu PROTEIN TRANSPORT
PROTEIN DSL1

(Saccharomyces
cerevisiae) 		PF11988
(Dsl1_N) 		4 ASN A  79
TYR A  81
GLU A  78
TYR A 124
 None
 1.20A 4mj8A-3etuA:
undetectable
4mj8C-3etuA:
undetectable		 4mj8A-3etuA:
18.80
4mj8C-3etuA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g65 CHECKPOINT PROTEIN
HUS1

(Homo sapiens) 		PF04005
(Hus1) 		4 ASN C 191
GLU C 195
GLU C 183
GLU C 229
 None
 1.10A 4mj8A-3g65C:
undetectable
4mj8C-3g65C:
undetectable		 4mj8A-3g65C:
21.71
4mj8C-3g65C:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k3p D-ALANINE--D-ALANINE
LIGASE

(Streptococcus
mutans) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 ASN A  35
GLU A   4
GLU A 331
TYR A 114
 None
 1.06A 4mj8A-3k3pA:
undetectable
4mj8C-3k3pA:
undetectable		 4mj8A-3k3pA:
18.44
4mj8C-3k3pA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxf SB27 T CELL RECEPTOR
ALPHA CHAIN

(Homo sapiens) 		PF07686
(V-set)
PF09291
(DUF1968) 		4 ASN D  57
GLU D  58
GLU D  55
TYR D  32
 None
 1.01A 4mj8A-3kxfD:
undetectable
4mj8C-3kxfD:
undetectable		 4mj8A-3kxfD:
17.56
4mj8C-3kxfD:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyf PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pseudomonas
putida) 		PF07238
(PilZ)
PF07317
(YcgR) 		4 ASN A 170
GLU A 206
GLU A 205
GLU A 172
 None
 1.22A 4mj8A-3kyfA:
undetectable
4mj8C-3kyfA:
undetectable		 4mj8A-3kyfA:
24.79
4mj8C-3kyfA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oq3 IFN-ALPHA/BETA
BINDING PROTEIN C12R
INTERFERON ALPHA-5

(Ectromelia
virus;
Mus musculus) 		PF00047
(ig)
PF00143
(Interferon)
PF13895
(Ig_2) 		4 ASN A  66
MET B  36
GLU B  54
GLU A  59
 None
 1.04A 4mj8A-3oq3A:
undetectable
4mj8C-3oq3A:
undetectable		 4mj8A-3oq3A:
22.45
4mj8C-3oq3A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oz7 PHOSPHOGLYCERATE
KINASE

(Plasmodium
falciparum) 		PF00162
(PGK) 		4 ASN A 356
GLU A 360
TYR A 323
GLU A 353
 None
 1.14A 4mj8A-3oz7A:
undetectable
4mj8C-3oz7A:
undetectable		 4mj8A-3oz7A:
17.75
4mj8C-3oz7A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pih UVRABC SYSTEM
PROTEIN A

(Thermotoga
maritima) 		PF00005
(ABC_tran) 		4 GLU A 492
GLU A 834
GLU A 865
TYR A 570
 None
 1.19A 4mj8A-3pihA:
undetectable
4mj8C-3pihA:
undetectable		 4mj8A-3pihA:
12.46
4mj8C-3pihA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qw2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE (INO1)

(Archaeoglobus
fulgidus) 		PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5) 		4 ASN A 198
TYR A 185
GLU A 151
TYR A 160
 None
NAD  A 396 (-4.3A)
None
None
 1.20A 4mj8A-3qw2A:
undetectable
4mj8C-3qw2A:
undetectable		 4mj8A-3qw2A:
19.19
4mj8C-3qw2A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rp9 MITOGEN-ACTIVATED
PROTEIN KINASE

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		4 ASN A 284
GLU A 155
TYR A 152
GLU A 283
 None
 1.19A 4mj8A-3rp9A:
undetectable
4mj8C-3rp9A:
undetectable		 4mj8A-3rp9A:
19.04
4mj8C-3rp9A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3srz TOXIN A

(Clostridioides
difficile) 		PF12918
(TcdB_N)
PF12919
(TcdA_TcdB) 		4 ASN A 333
MET A 313
GLU A 512
GLU A 332
 None
 1.21A 4mj8A-3srzA:
undetectable
4mj8C-3srzA:
undetectable		 4mj8A-3srzA:
16.03
4mj8C-3srzA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sun DNA POLYMERASE

(Escherichia
virus RB69) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 ASN A 228
GLU A 125
GLU A 261
TYR A 257
 None
 0.90A 4mj8A-3sunA:
undetectable
4mj8C-3sunA:
undetectable		 4mj8A-3sunA:
12.38
4mj8C-3sunA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ux8 EXCINUCLEASE ABC, A
SUBUNIT

(Geobacillus sp.
Y412MC52) 		PF00005
(ABC_tran) 		4 GLU A 512
GLU A 854
GLU A 885
TYR A 589
 None
 1.15A 4mj8A-3ux8A:
undetectable
4mj8C-3ux8A:
undetectable		 4mj8A-3ux8A:
14.14
4mj8C-3ux8A:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ux8 EXCINUCLEASE ABC, A
SUBUNIT

(Geobacillus sp.
Y412MC52) 		PF00005
(ABC_tran) 		4 GLU A 854
GLU A 512
GLU A 543
TYR A 931
 None
 1.05A 4mj8A-3ux8A:
undetectable
4mj8C-3ux8A:
undetectable		 4mj8A-3ux8A:
14.14
4mj8C-3ux8A:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wh9 ENDO-BETA-1,4-MANNAN
ASE

(Aspergillus
niger) 		PF00150
(Cellulase) 		4 GLU A 164
TYR A 111
GLU A 168
GLU A 204
 None
None
TRS  A 404 (-2.9A)
None
 1.19A 4mj8A-3wh9A:
1.1
4mj8C-3wh9A:
undetectable		 4mj8A-3wh9A:
18.86
4mj8C-3wh9A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wnv GLYOXYLATE REDUCTASE

(Paecilomyces
sp.
'thermophila') 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 ASN A 309
GLU A 302
GLU A 304
GLU A  18
 None
 1.09A 4mj8A-3wnvA:
undetectable
4mj8C-3wnvA:
undetectable		 4mj8A-3wnvA:
22.29
4mj8C-3wnvA:
22.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wr7 SPERMIDINE
N1-ACETYLTRANSFERASE

(Escherichia
coli) 		PF13302
(Acetyltransf_3) 		6 MET A  28
GLU A  33
GLU A  34
TYR A  36
GLU A  37
GLU A  41
 None
SPD  A 201 (-3.9A)
SPD  A 201 (-4.0A)
SPD  A 201 (-4.6A)
None
SPD  A 201 (-3.1A)
 0.79A 4mj8A-3wr7A:
28.7
4mj8C-3wr7A:
28.7		 4mj8A-3wr7A:
57.06
4mj8C-3wr7A:
57.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zi5 RESTRICTION
ENDONUCLEASE

(Bacillus firmus) 		no annotation 4 ASN A 260
TYR A 312
GLU A 313
TYR A 330
 None
 1.21A 4mj8A-3zi5A:
undetectable
4mj8C-3zi5A:
undetectable		 4mj8A-3zi5A:
19.90
4mj8C-3zi5A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE

(Podospora
anserina) 		PF00150
(Cellulase) 		4 GLU A 165
TYR A 113
GLU A 169
GLU A 205
 None
None
TRS  A1352 (-2.8A)
None
 1.13A 4mj8A-3zizA:
0.9
4mj8C-3zizA:
undetectable		 4mj8A-3zizA:
16.80
4mj8C-3zizA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES

(Mycolicibacterium
smegmatis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 ASN A 242
GLU A 237
GLU A 244
TYR A 190
 None
CA  A1589 (-2.9A)
None
None
 1.21A 4mj8A-3zo9A:
undetectable
4mj8C-3zo9A:
undetectable		 4mj8A-3zo9A:
16.57
4mj8C-3zo9A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zqj UVRABC SYSTEM
PROTEIN A

(Mycobacterium
tuberculosis) 		PF00005
(ABC_tran) 		4 GLU A 528
GLU A 871
GLU A 902
TYR A 605
 None
 1.18A 4mj8A-3zqjA:
undetectable
4mj8C-3zqjA:
undetectable		 4mj8A-3zqjA:
10.85
4mj8C-3zqjA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zty MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE

(Thermus
thermophilus) 		PF08282
(Hydrolase_3) 		4 GLU A  23
GLU A 244
TYR A 241
GLU A 237
 None
 1.20A 4mj8A-3ztyA:
undetectable
4mj8C-3ztyA:
undetectable		 4mj8A-3ztyA:
22.51
4mj8C-3ztyA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ala FAB 2H12 HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 MET H  20
GLU H   6
GLU H  37
TYR H  32
 None
 1.05A 4mj8A-4alaH:
undetectable
4mj8C-4alaH:
undetectable		 4mj8A-4alaH:
19.56
4mj8C-4alaH:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crn ERF3 IN RIBOSOME
BOUND
ERF1-ERF3-GDPNP
COMPLEX

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		4 GLU P 333
GLU P 548
GLU P 536
TYR P 281
 None
 1.15A 4mj8A-4crnP:
undetectable
4mj8C-4crnP:
undetectable		 4mj8A-4crnP:
16.94
4mj8C-4crnP:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d10 COP9 SIGNALOSOME
COMPLEX SUBUNIT 8

(Homo sapiens) 		PF10075
(CSN8_PSD8_EIF3K) 		4 ASN H  22
GLU H  21
GLU H  24
TYR H  55
 None
 1.11A 4mj8A-4d10H:
undetectable
4mj8C-4d10H:
undetectable		 4mj8A-4d10H:
20.98
4mj8C-4d10H:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dxy CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		4 MET A 306
GLU A  84
GLU A  94
TYR A 111
 PEG  A 504 ( 3.8A)
PEG  A 504 (-4.0A)
None
None
 1.20A 4mj8A-4dxyA:
undetectable
4mj8C-4dxyA:
undetectable		 4mj8A-4dxyA:
16.67
4mj8C-4dxyA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f3n UNCHARACTERIZED ACR,
COG1565 SUPERFAMILY

(Burkholderia
thailandensis) 		PF02636
(Methyltransf_28) 		4 ASN A 370
GLU A 380
GLU A  94
TYR A 277
 None
 1.12A 4mj8A-4f3nA:
undetectable
4mj8C-4f3nA:
undetectable		 4mj8A-4f3nA:
15.90
4mj8C-4f3nA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gn8 REGUCALCIN

(Mus musculus) 		PF08450
(SGL) 		4 ASN A 103
MET A 118
GLU A 121
GLU A 120
 ASO  A 305 ( 3.0A)
ASO  A 305 ( 4.4A)
ASO  A 305 (-2.4A)
None
 1.07A 4mj8A-4gn8A:
undetectable
4mj8C-4gn8A:
undetectable		 4mj8A-4gn8A:
20.60
4mj8C-4gn8A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gqz PUTATIVE PERIPLASMIC
OR EXPORTED PROTEIN

(Salmonella
enterica) 		no annotation 4 GLU A 107
TYR A  89
GLU A  90
TYR A 133
 None
 1.15A 4mj8A-4gqzA:
undetectable
4mj8C-4gqzA:
undetectable		 4mj8A-4gqzA:
20.62
4mj8C-4gqzA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ihq FLAI ATPASE

(Sulfolobus
acidocaldarius) 		PF00437
(T2SSE) 		4 ASN A 190
GLU A 308
TYR A 208
TYR A 184
 None
 1.13A 4mj8A-4ihqA:
undetectable
4mj8C-4ihqA:
undetectable		 4mj8A-4ihqA:
16.34
4mj8C-4ihqA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3c OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA

([Haemophilus]
ducreyi) 		PF01103
(Bac_surface_Ag)
PF07244
(POTRA) 		4 GLU A 538
GLU A 540
TYR A 541
TYR A 648
 None
 1.18A 4mj8A-4k3cA:
undetectable
4mj8C-4k3cA:
undetectable		 4mj8A-4k3cA:
16.76
4mj8C-4k3cA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kxr PPE41

(Mycobacterium
tuberculosis) 		PF00823
(PPE) 		4 ASN B  11
MET B 103
GLU B 148
GLU B   4
 None
 1.19A 4mj8A-4kxrB:
undetectable
4mj8C-4kxrB:
undetectable		 4mj8A-4kxrB:
23.41
4mj8C-4kxrB:
23.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mi4 SPERMIDINE
N1-ACETYLTRANSFERASE

(Vibrio cholerae) 		PF13302
(Acetyltransf_3) 		7 ASN A  22
MET A  28
GLU A  33
GLU A  34
TYR A  36
GLU A  37
GLU A  41
 SPM  A 201 (-3.7A)
SPM  A 201 ( 4.5A)
SPM  A 201 (-3.2A)
SPM  A 201 (-4.1A)
SPM  A 201 (-4.7A)
SPM  A 201 (-3.5A)
SPM  A 201 (-2.8A)
 0.11A 4mj8A-4mi4A:
31.8
4mj8C-4mi4A:
30.9		 4mj8A-4mi4A:
100.00
4mj8C-4mi4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mkv RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN
RIBULOSE
BISPHOSPHATE
CARBOXYLASE SMALL
CHAIN 3A,
CHLOROPLASTIC

(Pisum sativum) 		PF00016
(RuBisCO_large)
PF00101
(RuBisCO_small)
PF02788
(RuBisCO_large_N) 		4 ASN A 420
GLU A 425
TYR S  17
TYR A 165
 None
 1.11A 4mj8A-4mkvA:
undetectable
4mj8C-4mkvA:
undetectable		 4mj8A-4mkvA:
16.89
4mj8C-4mkvA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mnu SLYA-LIKE
TRANSCRIPTION
REGULATOR

(Listeria
monocytogenes) 		PF01047
(MarR) 		4 ASN A 105
TYR A 107
GLU A 104
GLU A  22
 None
 1.16A 4mj8A-4mnuA:
undetectable
4mj8C-4mnuA:
undetectable		 4mj8A-4mnuA:
24.61
4mj8C-4mnuA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP

(Lactococcus
lactis) 		PF00082
(Peptidase_S8) 		4 ASN A 338
GLU A 290
GLU A 293
TYR A 332
 None
 1.21A 4mj8A-4mzdA:
undetectable
4mj8C-4mzdA:
undetectable		 4mj8A-4mzdA:
17.01
4mj8C-4mzdA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgp CSM6_III-A

(Streptococcus
mutans) 		PF09659
(Cas_Csm6) 		4 ASN A  72
GLU A  75
TYR A  74
GLU A  77
 None
 1.11A 4mj8A-4rgpA:
undetectable
4mj8C-4rgpA:
undetectable		 4mj8A-4rgpA:
24.43
4mj8C-4rgpA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4roq MALYL-COA
LYASE/BETA-METHYLMAL
YL-COA LYASE

(Methylobacterium
extorquens) 		PF03328
(HpcH_HpaI) 		4 MET A 101
GLU A 159
GLU A 251
TYR A 220
 None
 1.18A 4mj8A-4roqA:
undetectable
4mj8C-4roqA:
undetectable		 4mj8A-4roqA:
18.40
4mj8C-4roqA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uxv SEPTATION RING
FORMATION REGULATOR
EZRA

(Bacillus
subtilis) 		PF06160
(EzrA) 		4 ASN A 404
GLU A 411
GLU A 337
GLU A 345
 None
 1.14A 4mj8A-4uxvA:
undetectable
4mj8C-4uxvA:
undetectable		 4mj8A-4uxvA:
16.15
4mj8C-4uxvA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0b ANTIBODY HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 MET H 109
GLU H  35
TYR H  95
TYR H  80
 None
 1.21A 4mj8A-4z0bH:
undetectable
4mj8C-4z0bH:
undetectable		 4mj8A-4z0bH:
17.11
4mj8C-4z0bH:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgv FERREDOXIN RECEPTOR

(Pectobacterium
atrosepticum) 		PF07715
(Plug) 		4 ASN A 583
TYR A 459
GLU A 586
TYR A 490
 None
 1.17A 4mj8A-4zgvA:
undetectable
4mj8C-4zgvA:
undetectable		 4mj8A-4zgvA:
11.82
4mj8C-4zgvA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gt5 PECTATE LYASE

(Paenibacillus
sp. 0602) 		no annotation 4 ASN A  59
GLU A 134
GLU A  64
TYR A 173
 None
 0.91A 4mj8A-5gt5A:
undetectable
4mj8C-5gt5A:
undetectable		 4mj8A-5gt5A:
17.71
4mj8C-5gt5A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3

(Saccharomyces
cerevisiae) 		PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L) 		4 ASN C 206
GLU C 177
TYR C 180
GLU C 179
 None
 1.20A 4mj8A-5ip7C:
undetectable
4mj8C-5ip7C:
undetectable		 4mj8A-5ip7C:
22.45
4mj8C-5ip7C:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ksp MITOCHONDRIAL RHO
GTPASE 1

(Homo sapiens) 		PF00071
(Ras) 		4 ASN A 500
GLU A 537
GLU A 505
TYR A 506
 None
 1.20A 4mj8A-5kspA:
undetectable
4mj8C-5kspA:
undetectable		 4mj8A-5kspA:
21.46
4mj8C-5kspA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ku1 MITOCHONDRIAL RHO
GTPASE 1

(Homo sapiens) 		PF08355
(EF_assoc_1)
PF08356
(EF_assoc_2) 		4 ASN A 500
GLU A 537
GLU A 505
TYR A 506
 None
 1.08A 4mj8A-5ku1A:
undetectable
4mj8C-5ku1A:
undetectable		 4mj8A-5ku1A:
16.98
4mj8C-5ku1A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzl HEME OXYGENASE

(Leptospira
interrogans) 		PF01126
(Heme_oxygenase) 		4 MET A  51
GLU A  52
GLU A  49
TYR A  46
 None
 1.06A 4mj8A-5kzlA:
undetectable
4mj8C-5kzlA:
undetectable		 4mj8A-5kzlA:
23.77
4mj8C-5kzlA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lnb UBIQUITIN-LIKE-SPECI
FIC PROTEASE 2

(Saccharomyces
cerevisiae) 		PF02902
(Peptidase_C48) 		4 ASN B 291
GLU B 290
TYR B 293
TYR B  29
 None
 1.13A 4mj8A-5lnbB:
undetectable
4mj8C-5lnbB:
2.7		 4mj8A-5lnbB:
21.33
4mj8C-5lnbB:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale) 		PF07992
(Pyr_redox_2) 		4 ASN A 423
GLU A 122
GLU A 119
GLU A 464
 None
 1.05A 4mj8A-5m10A:
undetectable
4mj8C-5m10A:
undetectable		 4mj8A-5m10A:
16.45
4mj8C-5m10A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mun LYS-GINGIPAIN W83

(Porphyromonas
gingivalis) 		PF08126
(Propeptide_C25) 		4 ASN A  50
GLU A  51
GLU A  53
TYR A 179
 None
 1.10A 4mj8A-5munA:
undetectable
4mj8C-5munA:
undetectable		 4mj8A-5munA:
20.80
4mj8C-5munA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqd ARSENITE OXIDASE
LARGE SUBUNIT AIOA
[3FE-4S] CLUSTER,
MO-MOLYBDOPTERIN
COFACTOR-BINDING
ACTIVE SITE

(Rhizobium sp.
NT-26) 		no annotation 4 MET A 633
GLU A 629
GLU A 178
TYR A 177
 None
 1.15A 4mj8A-5nqdA:
undetectable
4mj8C-5nqdA:
undetectable		 4mj8A-5nqdA:
16.35
4mj8C-5nqdA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT) 		4 ASN T1077
GLU T1084
GLU T 971
TYR T1207
 None
 1.23A 4mj8A-5ojsT:
undetectable
4mj8C-5ojsT:
undetectable		 4mj8A-5ojsT:
4.25
4mj8C-5ojsT:
4.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tu9 ACCUMULATION
ASSOCIATED PROTEIN
AAP G58-SPACER-G513
(VARIANT
G5-SPACER-CONSENSUS
G5)

(Staphylococcus
epidermidis) 		PF07501
(G5)
PF17041
(SasG_E) 		4 ASN A  21
GLU A  28
GLU A  29
GLU A  75
 None
 0.91A 4mj8A-5tu9A:
undetectable
4mj8C-5tu9A:
undetectable		 4mj8A-5tu9A:
19.53
4mj8C-5tu9A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		4 GLU A1226
GLU A1214
GLU A1454
TYR A1505
 None
 1.19A 4mj8A-5vadA:
undetectable
4mj8C-5vadA:
undetectable		 4mj8A-5vadA:
17.35
4mj8C-5vadA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vai UNCHARACTERIZED
PROTEIN

(Oryctolagus
cuniculus) 		PF00002
(7tm_2)
PF02793
(HRM) 		4 ASN R 240
GLU R 247
TYR R 242
TYR R 252
 None
 1.16A 4mj8A-5vaiR:
undetectable
4mj8C-5vaiR:
undetectable		 4mj8A-5vaiR:
15.07
4mj8C-5vaiR:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wtk CRISPR-ASSOCIATED
ENDORIBONUCLEASE
C2C2

(Leptotrichia
shahii) 		no annotation 4 ASN A 753
TYR A 755
GLU A 752
TYR A 781
 None
 1.16A 4mj8A-5wtkA:
undetectable
4mj8C-5wtkA:
undetectable		 4mj8A-5wtkA:
8.76
4mj8C-5wtkA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjs GEM-ASSOCIATED
PROTEIN 2

(Homo sapiens) 		no annotation 4 ASN 2 200
GLU 2 204
GLU 2 141
GLU 2 142
 None
 1.17A 4mj8A-5xjs2:
undetectable
4mj8C-5xjs2:
undetectable		 4mj8A-5xjs2:
18.24
4mj8C-5xjs2:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xns CHROMOSOME PARTITION
PROTEIN SMC

(Pyrococcus
furiosus) 		PF02463
(SMC_N) 		4 ASN A 189
GLU A 994
GLU A 992
GLU A 187
 None
 0.97A 4mj8A-5xnsA:
undetectable
4mj8C-5xnsA:
undetectable		 4mj8A-5xnsA:
20.94
4mj8C-5xnsA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yud BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 1E

(Mus musculus) 		no annotation 4 ASN A 976
GLU A 969
TYR A 974
GLU A 975
 None
 1.14A 4mj8A-5yudA:
undetectable
4mj8C-5yudA:
undetectable		 4mj8A-5yudA:
18.64
4mj8C-5yudA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zji CHLOROPHYLL A-B
BINDING PROTEIN,
CHLOROPLASTIC
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT III

(Zea mays) 		no annotation 4 ASN 4  88
GLU F 209
GLU 4  84
TYR F 170
 None
None
None
CLA  F 301 (-4.8A)
 1.14A 4mj8A-5zji4:
undetectable
4mj8C-5zji4:
undetectable		 4mj8A-5zji4:
16.76
4mj8C-5zji4:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9m N-ALPHA-ACETYLTRANSF
ERASE 10
N-ALPHA-ACETYLTRANSF
ERASE 15, NATA
AUXILIARY SUBUNIT

(Homo sapiens) 		no annotation 4 ASN B  13
GLU B   9
TYR B  31
TYR A 538
 None
 1.23A 4mj8A-6c9mB:
13.6
4mj8C-6c9mB:
13.8		 4mj8A-6c9mB:
20.57
4mj8C-6c9mB:
20.57