SIMILAR PATTERNS OF AMINO ACIDS FOR 4MI4_A_SPMA201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ajz DIHYDROPTEROATE
SYNTHASE

(Escherichia
coli) 		PF00809
(Pterin_bind) 		4 ASN A 162
GLU A 167
TYR A 164
GLU A 160
 None
 1.19A 4mi4A-1ajzA:
0.5		 4mi4A-1ajzA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bik BIKUNIN

(Homo sapiens) 		PF00014
(Kunitz_BPTI) 		4 ASN A  45
GLU A  69
TYR A  42
GLU A  52
 NAG  A 148 (-1.7A)
None
None
NAG  A 148 ( 4.0A)
 1.31A 4mi4A-1bikA:
undetectable		 4mi4A-1bikA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c2o ACETYLCHOLINESTERASE

(Electrophorus
electricus) 		PF00135
(COesterase) 		4 ASN A 514
GLU A 519
TYR A 428
GLU A 431
 None
 1.03A 4mi4A-1c2oA:
1.7		 4mi4A-1c2oA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF03173
(CHB_HEX)
PF03174
(CHB_HEX_C) 		5 ASN A 719
GLU A 782
GLU A 708
TYR A 778
GLU A 777
 None
 1.27A 4mi4A-1c7tA:
undetectable		 4mi4A-1c7tA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6y METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
METHYL-COENZYME M
REDUCTASE SUBUNIT
GAMMA

(Methanosarcina
barkeri) 		PF02240
(MCR_gamma)
PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		4 GLU B2255
GLU B2267
TYR C3003
GLU B2275
 None
 1.41A 4mi4A-1e6yB:
0.0		 4mi4A-1e6yB:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ej8 LYS7

(Saccharomyces
cerevisiae) 		PF00080
(Sod_Cu) 		4 GLU A 200
GLU A 202
TYR A  90
GLU A 125
 None
 1.44A 4mi4A-1ej8A:
undetectable		 4mi4A-1ej8A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i84 SMOOTH MUSCLE MYOSIN
HEAVY CHAIN

(Gallus gallus) 		PF00063
(Myosin_head)
PF00612
(IQ)
PF01576
(Myosin_tail_1)
PF02736
(Myosin_N) 		4 ASN S 708
GLU S 703
GLU S  97
GLU S 712
 None
 1.43A 4mi4A-1i84S:
0.0		 4mi4A-1i84S:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m53 ISOMALTULOSE
SYNTHASE

(Klebsiella sp.
LX3) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 ASN A 503
GLU A 495
GLU A 410
TYR A 505
 None
 1.31A 4mi4A-1m53A:
1.0		 4mi4A-1m53A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oz7 ECHICETIN A-CHAIN
ECHICETIN B-CHAIN

(Echis carinatus) 		PF00059
(Lectin_C) 		4 ASN B  76
GLU B  78
GLU A  71
GLU A  99
 None
 1.43A 4mi4A-1oz7B:
undetectable		 4mi4A-1oz7B:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qnr ENDO-1,4-B-D-MANNANA
SE

(Trichoderma
reesei) 		PF00150
(Cellulase) 		4 ASN A 168
GLU A 165
GLU A 169
GLU A 205
 None
None
MAB  A 401 ( 2.8A)
MAB  A 401 (-3.9A)
 1.43A 4mi4A-1qnrA:
0.9		 4mi4A-1qnrA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rh1 COLICIN B

(Escherichia
coli) 		PF01024
(Colicin)
PF03515
(Cloacin) 		4 ASN A 303
GLU A 299
GLU A 301
TYR A 259
 None
 1.18A 4mi4A-1rh1A:
undetectable		 4mi4A-1rh1A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tly NUCLEOSIDE-SPECIFIC
CHANNEL-FORMING
PROTEIN TSX

(Escherichia
coli) 		PF03502
(Channel_Tsx) 		4 GLU A  79
TYR A  39
GLU A  38
GLU A  40
 None
 1.40A 4mi4A-1tlyA:
undetectable		 4mi4A-1tlyA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w45 ANNEXIN A8

(Homo sapiens) 		PF00191
(Annexin) 		4 GLU A 101
GLU A  98
TYR A  95
GLU A  11
 None
 1.47A 4mi4A-1w45A:
undetectable		 4mi4A-1w45A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wza ALPHA-AMYLASE A

(Halothermothrix
orenii) 		PF00128
(Alpha-amylase) 		4 ASN A 419
GLU A 411
GLU A 366
TYR A 421
 None
 1.36A 4mi4A-1wzaA:
0.9		 4mi4A-1wzaA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfb ALDOLASE C

(Homo sapiens) 		PF00274
(Glycolytic) 		4 ASN A 283
GLU A 247
GLU A 248
TYR A 244
 None
 1.44A 4mi4A-1xfbA:
1.1		 4mi4A-1xfbA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zl9 GLUTATHIONE
S-TRANSFERASE 5

(Caenorhabditis
elegans) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 ASN A  32
GLU A  57
TYR A  29
GLU A  30
 None
 1.05A 4mi4A-1zl9A:
undetectable		 4mi4A-1zl9A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d9j REGULATOR OF
G-PROTEIN SIGNALLING
7

(Homo sapiens) 		PF00615
(RGS) 		4 ASN A  44
GLU A  39
GLU A  37
GLU A  43
 None
 1.17A 4mi4A-2d9jA:
undetectable		 4mi4A-2d9jA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e18 NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Pyrococcus
horikoshii) 		PF02540
(NAD_synthase) 		4 ASN A 198
GLU A 160
TYR A 157
GLU A 202
 None
None
None
ZN  A1304 ( 2.2A)
 1.08A 4mi4A-2e18A:
undetectable		 4mi4A-2e18A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g9i F420-0:GAMMA-GLUTAMY
L LIGASE

(Archaeoglobus
fulgidus) 		PF01996
(F420_ligase) 		4 ASN A  57
GLU A  74
GLU A  55
GLU A  81
 None
 1.33A 4mi4A-2g9iA:
undetectable		 4mi4A-2g9iA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gks BIFUNCTIONAL SAT/APS
KINASE

(Aquifex
aeolicus) 		PF01583
(APS_kinase)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 ASN A  42
GLU A  37
TYR A  40
GLU A  45
 None
 1.38A 4mi4A-2gksA:
undetectable		 4mi4A-2gksA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Mycobacterium
tuberculosis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 GLU A 198
GLU A 241
GLU A 202
GLU A 119
 None
 0.85A 4mi4A-2gp6A:
undetectable		 4mi4A-2gp6A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mk6 ADAPTER PROTEIN MECA

(Bacillus
subtilis) 		PF05389
(MecA) 		4 GLU A   4
GLU A  72
TYR A  14
GLU A   2
 None
 1.01A 4mi4A-2mk6A:
undetectable		 4mi4A-2mk6A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nsm CARBOXYPEPTIDASE N
CATALYTIC CHAIN

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg) 		4 ASN A 110
GLU A  36
GLU A 115
TYR A 114
 None
 1.40A 4mi4A-2nsmA:
undetectable		 4mi4A-2nsmA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfm ADENYLOSUCCINATE
LYASE

(Bacillus
anthracis) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		4 ASN A 346
GLU A 341
TYR A 339
GLU A 252
 None
 1.36A 4mi4A-2pfmA:
undetectable		 4mi4A-2pfmA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pun METHYLTHIORIBOSE
KINASE

(Bacillus
subtilis) 		PF01636
(APH) 		4 ASN A 290
GLU A 283
TYR A 286
GLU A 389
 None
None
None
CPS  A 777 (-3.5A)
 1.00A 4mi4A-2punA:
undetectable		 4mi4A-2punA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vhh CG3027-PA

(Drosophila
melanogaster) 		PF00795
(CN_hydrolase) 		4 ASN A 145
GLU A 173
GLU A 169
GLU A 144
 None
 1.05A 4mi4A-2vhhA:
undetectable		 4mi4A-2vhhA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wa0 MELANOMA-ASSOCIATED
ANTIGEN 4

(Homo sapiens) 		PF01454
(MAGE) 		4 GLU A 221
GLU A 219
TYR A 270
GLU A 271
 None
 0.99A 4mi4A-2wa0A:
undetectable		 4mi4A-2wa0A:
27.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xom ARABINOGALACTAN
ENDO-1,4-BETA-GALACT
OSIDASE

(Thermotoga
maritima) 		no annotation 4 ASN A 133
GLU A 130
TYR A  88
GLU A 165
 None
 1.04A 4mi4A-2xomA:
undetectable		 4mi4A-2xomA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME

(Homo sapiens) 		PF01401
(Peptidase_M2) 		4 ASN A 246
GLU A 608
GLU A 606
TYR A 250
 None
 1.33A 4mi4A-2xy9A:
undetectable		 4mi4A-2xy9A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yoc PULLULANASE

(Klebsiella
oxytoca) 		PF02922
(CBM_48)
PF03714
(PUD)
PF11852
(DUF3372) 		4 GLU A 475
GLU A 377
TYR A 378
GLU A 564
 CA  A2071 (-3.0A)
None
None
None
 1.14A 4mi4A-2yocA:
undetectable		 4mi4A-2yocA:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN

(Aeropyrum
pernix) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		4 GLU A 279
TYR A 240
GLU A 286
GLU A 282
 None
 1.25A 4mi4A-2yv2A:
undetectable		 4mi4A-2yv2A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yvt HYPOTHETICAL PROTEIN
AQ_1956

(Aquifex
aeolicus) 		PF14582
(Metallophos_3) 		4 ASN A  99
GLU A 149
GLU A  49
GLU A  53
 None
 1.11A 4mi4A-2yvtA:
undetectable		 4mi4A-2yvtA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yyy GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF01113
(DapB_N)
PF02800
(Gp_dh_C) 		4 ASN A  97
GLU A 115
TYR A 138
GLU A  99
 NAP  A2001 (-3.3A)
None
None
None
 1.13A 4mi4A-2yyyA:
undetectable		 4mi4A-2yyyA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z13 EF-HAND
DOMAIN-CONTAINING
FAMILY MEMBER C2

(Homo sapiens) 		PF06565
(DUF1126) 		4 GLU A  24
TYR A  38
GLU A  54
GLU A  56
 None
 1.29A 4mi4A-2z13A:
undetectable		 4mi4A-2z13A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bc9 ALPHA AMYLASE,
CATALYTIC REGION

(Halothermothrix
orenii) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		4 GLU A 141
TYR A 486
GLU A 144
GLU A 145
 None
 1.45A 4mi4A-3bc9A:
undetectable		 4mi4A-3bc9A:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c37 PEPTIDASE, M48
FAMILY

(Geobacter
sulfurreducens) 		PF01435
(Peptidase_M48) 		4 ASN A 109
GLU A 162
TYR A 157
GLU A 107
 None
ZN  A 301 (-2.2A)
None
None
 1.11A 4mi4A-3c37A:
undetectable		 4mi4A-3c37A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f3k UNCHARACTERIZED
PROTEIN YKR043C

(Saccharomyces
cerevisiae) 		PF00300
(His_Phos_1) 		4 GLU A 106
GLU A  99
GLU A 101
GLU A 139
 None
 1.37A 4mi4A-3f3kA:
undetectable		 4mi4A-3f3kA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fn9 PUTATIVE
BETA-GALACTOSIDASE

(Bacteroides
fragilis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		4 ASN A 689
GLU A 687
GLU A 615
GLU A 515
 None
 1.38A 4mi4A-3fn9A:
undetectable		 4mi4A-3fn9A:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g65 CHECKPOINT PROTEIN
HUS1

(Homo sapiens) 		PF04005
(Hus1) 		4 ASN C 191
GLU C 195
GLU C 183
GLU C 229
 None
 1.10A 4mi4A-3g65C:
undetectable		 4mi4A-3g65C:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3juj UDP-GLUCOSE
PYROPHOSPHORYLASE
(GALU)

(Helicobacter
pylori) 		PF00483
(NTP_transferase) 		4 ASN A 200
GLU A 166
TYR A 170
GLU A 160
 None
 1.27A 4mi4A-3jujA:
undetectable		 4mi4A-3jujA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ki6 CHOLIX TOXIN

(Vibrio cholerae) 		PF09009
(Exotox-A_cataly) 		4 ASN A 602
GLU A 605
TYR A 604
GLU A 606
 None
 1.35A 4mi4A-3ki6A:
undetectable		 4mi4A-3ki6A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyf PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pseudomonas
putida) 		PF07238
(PilZ)
PF07317
(YcgR) 		4 ASN A 170
GLU A 206
GLU A 205
GLU A 172
 None
 1.23A 4mi4A-3kyfA:
undetectable		 4mi4A-3kyfA:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkq COATOMER
BETA'-SUBUNIT

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF04053
(Coatomer_WDAD) 		4 ASN A 621
GLU A 605
GLU A 617
GLU A 614
 None
 1.22A 4mi4A-3mkqA:
undetectable		 4mi4A-3mkqA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oz7 PHOSPHOGLYCERATE
KINASE

(Plasmodium
falciparum) 		PF00162
(PGK) 		4 ASN A 356
GLU A 360
TYR A 323
GLU A 353
 None
 1.13A 4mi4A-3oz7A:
undetectable		 4mi4A-3oz7A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pua PHD FINGER PROTEIN 2

(Homo sapiens) 		PF02373
(JmjC) 		4 GLU A 282
GLU A 352
TYR A 349
GLU A 350
 None
 1.33A 4mi4A-3puaA:
undetectable		 4mi4A-3puaA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9o EXOTOXIN A

(Vibrio cholerae) 		PF09009
(Exotox-A_cataly)
PF09101
(Exotox-A_bind)
PF09102
(Exotox-A_target) 		4 ASN A 602
GLU A 605
TYR A 604
GLU A 606
 None
 1.39A 4mi4A-3q9oA:
undetectable		 4mi4A-3q9oA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r11 ENZYME OF ENOLASE
SUPERFAMILY

(Francisella
philomiragia) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ASN A 194
GLU A 220
TYR A 225
GLU A 246
 MG  A 382 ( 4.7A)
MG  A 382 (-2.9A)
GOL  A 383 (-4.8A)
MG  A 382 ( 3.9A)
 1.42A 4mi4A-3r11A:
1.3		 4mi4A-3r11A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rp9 MITOGEN-ACTIVATED
PROTEIN KINASE

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		4 ASN A 284
GLU A 155
TYR A 152
GLU A 283
 None
 1.19A 4mi4A-3rp9A:
undetectable		 4mi4A-3rp9A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6p CAPSID PROTEIN

(Helicoverpa
armigera stunt
virus) 		PF03566
(Peptidase_A21) 		4 GLU A 137
GLU A 136
TYR A 134
GLU A 203
 None
 1.32A 4mi4A-3s6pA:
undetectable		 4mi4A-3s6pA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u92 GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 3

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		4 ASN A 172
GLU A 189
TYR A 195
GLU A  13
 KAI  A 258 (-3.1A)
KAI  A 258 (-2.5A)
None
KAI  A 258 (-3.1A)
 1.06A 4mi4A-3u92A:
undetectable		 4mi4A-3u92A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vgf MALTO-OLIGOSYLTREHAL
OSE TREHALOHYDROLASE

(Sulfolobus
solfataricus) 		PF00128
(Alpha-amylase)
PF09071
(Alpha-amyl_C) 		4 ASN A 375
GLU A 283
GLU A 106
GLU A 137
 None
GLC  A 604 (-2.6A)
None
None
 1.32A 4mi4A-3vgfA:
undetectable		 4mi4A-3vgfA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfl BETA-MANNANASE

(Talaromyces
trachyspermus) 		PF00150
(Cellulase) 		4 ASN A 200
GLU A 197
GLU A 201
GLU A 237
 TRS  A 402 (-2.7A)
None
TRS  A 402 (-2.7A)
None
 1.46A 4mi4A-3wflA:
undetectable		 4mi4A-3wflA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wh9 ENDO-BETA-1,4-MANNAN
ASE

(Aspergillus
niger) 		PF00150
(Cellulase) 		4 GLU A 164
TYR A 111
GLU A 168
GLU A 204
 None
None
TRS  A 404 (-2.9A)
None
 1.16A 4mi4A-3wh9A:
undetectable		 4mi4A-3wh9A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wnv GLYOXYLATE REDUCTASE

(Paecilomyces
sp.
'thermophila') 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 ASN A 309
GLU A 302
GLU A 304
GLU A  18
 None
 1.07A 4mi4A-3wnvA:
undetectable		 4mi4A-3wnvA:
22.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wr7 SPERMIDINE
N1-ACETYLTRANSFERASE

(Escherichia
coli) 		PF13302
(Acetyltransf_3) 		5 GLU A  33
GLU A  34
TYR A  36
GLU A  37
GLU A  41
 SPD  A 201 (-3.9A)
SPD  A 201 (-4.0A)
SPD  A 201 (-4.6A)
None
SPD  A 201 (-3.1A)
 0.89A 4mi4A-3wr7A:
28.6		 4mi4A-3wr7A:
53.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE

(Podospora
anserina) 		PF00150
(Cellulase) 		4 GLU A 165
TYR A 113
GLU A 169
GLU A 205
 None
None
TRS  A1352 (-2.8A)
None
 1.10A 4mi4A-3zizA:
undetectable		 4mi4A-3zizA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zty MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE

(Thermus
thermophilus) 		PF08282
(Hydrolase_3) 		4 GLU A  23
GLU A 244
TYR A 241
GLU A 237
 None
 1.19A 4mi4A-3ztyA:
undetectable		 4mi4A-3ztyA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amf PHOX

(Pseudomonas
fluorescens) 		PF05787
(DUF839) 		4 ASN A  68
GLU A  90
TYR A  91
GLU A 532
 None
FEO  A1595 ( 2.6A)
None
CA  A1594 (-2.3A)
 1.27A 4mi4A-4amfA:
undetectable		 4mi4A-4amfA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ctd OUTER MEMBRANE
PROTEIN G

(Escherichia
coli) 		PF09381
(Porin_OmpG) 		4 GLU A 241
TYR A  14
GLU A  15
GLU A  31
 CL  A1273 (-3.9A)
None
None
None
 1.32A 4mi4A-4ctdA:
undetectable		 4mi4A-4ctdA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dns FAD-LINKED
OXIDOREDUCTASE BG60

(Cynodon
dactylon) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 ASN A 489
GLU A  91
GLU A 490
GLU A  98
 FAD  A 501 (-4.4A)
None
None
None
 1.39A 4mi4A-4dnsA:
undetectable		 4mi4A-4dnsA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f67 UPF0176 PROTEIN
LPG2838

(Legionella
pneumophila) 		PF00581
(Rhodanese) 		4 ASN A 134
GLU A 139
TYR A 138
GLU A 137
 None
 1.40A 4mi4A-4f67A:
undetectable		 4mi4A-4f67A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gn1 RAS-ASSOCIATED AND
PLECKSTRIN HOMOLOGY
DOMAINS-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00169
(PH)
PF00788
(RA) 		4 ASN A 336
GLU A 316
GLU A 331
GLU A 328
 MLI  A 601 (-3.6A)
MLI  A 601 (-2.7A)
None
None
 1.34A 4mi4A-4gn1A:
undetectable		 4mi4A-4gn1A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4he4 YELLOW FLUORESCENT
PROTEIN

(Phialidium sp.
SL-2003) 		PF01353
(GFP) 		4 ASN A 119
GLU A 113
TYR A 118
GLU A  17
 CRO  A  65 ( 4.0A)
None
None
None
 1.34A 4mi4A-4he4A:
undetectable		 4mi4A-4he4A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i9c RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE F

(Bacillus
subtilis) 		PF12895
(ANAPC3)
PF13424
(TPR_12) 		4 ASN A  61
GLU A  30
GLU A  68
GLU A  71
 None
 1.26A 4mi4A-4i9cA:
undetectable		 4mi4A-4i9cA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iwb FLIC, FLIS CHIMERA

(Aquifex
aeolicus) 		PF00700
(Flagellin_C)
PF02561
(FliS) 		4 ASN A  95
GLU A  71
GLU A  74
GLU A  78
 None
 1.38A 4mi4A-4iwbA:
undetectable		 4mi4A-4iwbA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iy9 30K PROTEIN 1

(Bombyx mori) 		PF03260
(Lipoprotein_11) 		4 ASN A  44
TYR A  15
GLU A  11
GLU A  12
 None
 1.50A 4mi4A-4iy9A:
undetectable		 4mi4A-4iy9A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jn6 4-HYDROXY-2-OXOVALER
ATE ALDOLASE

(Mycobacterium
tuberculosis) 		PF00682
(HMGL-like)
PF07836
(DmpG_comm) 		4 ASN A 103
GLU A  69
GLU A  67
GLU A  99
 None
 1.35A 4mi4A-4jn6A:
undetectable		 4mi4A-4jn6A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l83 UBE2I2 PROTEIN

(Brugia malayi) 		PF00179
(UQ_con) 		4 ASN A 141
GLU A 146
TYR A 145
GLU A 144
 None
 1.41A 4mi4A-4l83A:
undetectable		 4mi4A-4l83A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mnu SLYA-LIKE
TRANSCRIPTION
REGULATOR

(Listeria
monocytogenes) 		PF01047
(MarR) 		4 ASN A 105
TYR A 107
GLU A 104
GLU A  22
 None
 1.15A 4mi4A-4mnuA:
undetectable		 4mi4A-4mnuA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qts CRISPR TYPE
III-ASSOCIATED RAMP
PROTEIN CSM3
CRISPR TYPE
III-ASSOCIATED RAMP
PROTEIN CSM4

(Methanocaldococcus
jannaschii) 		PF03787
(RAMPs) 		4 GLU A 229
GLU A 245
GLU C 160
GLU C  13
 None
 1.29A 4mi4A-4qtsA:
undetectable		 4mi4A-4qtsA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4quf RE36324P

(Drosophila
melanogaster) 		PF00385
(Chromo) 		4 ASN A  63
TYR A  24
GLU A  23
GLU A  22
 None
 1.28A 4mi4A-4qufA:
undetectable		 4mi4A-4qufA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgp CSM6_III-A

(Streptococcus
mutans) 		PF09659
(Cas_Csm6) 		4 ASN A  72
GLU A  75
TYR A  74
GLU A  77
 None
 1.11A 4mi4A-4rgpA:
undetectable		 4mi4A-4rgpA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1v D-3-PHOSPHOGLYCERATE
DEHYDROGENASE-RELATE
D PROTEIN

(Vibrio cholerae) 		no annotation 4 GLU D 274
GLU D 267
GLU D 265
GLU D 240
 None
 1.25A 4mi4A-4s1vD:
undetectable		 4mi4A-4s1vD:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u8f PUTATIVE
UNCHARACTERIZED
PROTEIN GBS1892

(Streptococcus
agalactiae) 		PF02502
(LacAB_rpiB)
PF12408
(DUF3666) 		4 GLU A  43
GLU A  44
TYR A  39
GLU A 188
 None
 1.38A 4mi4A-4u8fA:
undetectable		 4mi4A-4u8fA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uxv SEPTATION RING
FORMATION REGULATOR
EZRA

(Bacillus
subtilis) 		PF06160
(EzrA) 		4 ASN A 404
GLU A 411
GLU A 337
GLU A 345
 None
 1.12A 4mi4A-4uxvA:
undetectable		 4mi4A-4uxvA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z81 EGF FAMILY
DOMAIN-CONTAINING
PROTEIN

(Toxoplasma
gondii) 		PF02430
(AMA-1)
PF07974
(EGF_2) 		4 GLU A 201
GLU A 172
TYR A 272
GLU A 195
 None
 1.42A 4mi4A-4z81A:
undetectable		 4mi4A-4z81A:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE

(Homo sapiens) 		PF00004
(AAA)
PF02359
(CDC48_N)
PF02933
(CDC48_2)
PF09336
(Vps4_C) 		4 ASN A  90
GLU A 196
GLU A 195
GLU A 162
 None
 1.34A 4mi4A-5c1bA:
undetectable		 4mi4A-5c1bA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5doo PROTEIN LYSINE
METHYLTRANSFERASE 2

(Rickettsia
typhi) 		PF10119
(MethyTransf_Reg)
PF13847
(Methyltransf_31) 		4 ASN A 368
GLU A 381
TYR A 363
GLU A 367
 None
 1.28A 4mi4A-5dooA:
1.8		 4mi4A-5dooA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f6v SUMO-CONJUGATING
ENZYME UBC9

(Homo sapiens) 		PF00179
(UQ_con) 		4 ASN A 140
GLU A 145
TYR A 144
GLU A 143
 None
 1.29A 4mi4A-5f6vA:
undetectable		 4mi4A-5f6vA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7s GLYCOSIDE HYDROLASE
FAMILY 31

(Trueperella
pyogenes) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 ASN A 305
GLU A 303
GLU A 330
GLU A 335
 None
 1.29A 4mi4A-5f7sA:
undetectable		 4mi4A-5f7sA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gam PRE-MRNA-SPLICING
FACTOR 8

(Saccharomyces
cerevisiae) 		PF08082
(PRO8NT)
PF08083
(PROCN) 		4 ASN A 178
GLU A 184
GLU A 188
GLU A 204
 None
None
None
U  U  33 ( 4.9A)
 1.49A 4mi4A-5gamA:
undetectable		 4mi4A-5gamA:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hs8 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR YODB

(Bacillus
subtilis) 		PF01638
(HxlR) 		4 GLU A  61
GLU A  58
TYR A  77
GLU A  64
 None
 1.37A 4mi4A-5hs8A:
undetectable		 4mi4A-5hs8A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihr PROBABLE
BETA-GALACTOSIDASE A

(Aspergillus
niger) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 ASN A 320
GLU A 377
GLU A 381
GLU A 322
 MAN  A1627 (-3.7A)
MAN  A1625 (-2.8A)
None
MAN  A1626 (-3.7A)
 1.24A 4mi4A-5ihrA:
undetectable		 4mi4A-5ihrA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3

(Saccharomyces
cerevisiae) 		PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L) 		4 ASN C 206
GLU C 177
TYR C 180
GLU C 179
 None
 1.25A 4mi4A-5ip7C:
undetectable		 4mi4A-5ip7C:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB11-A

(Homo sapiens) 		PF13656
(RNA_pol_L_2) 		4 ASN K  36
GLU K  68
GLU K   8
GLU K  16
 None
 1.29A 4mi4A-5iy7K:
undetectable		 4mi4A-5iy7K:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5koh NITROGENASE FEMO
BETA SUBUNIT PROTEIN
NIFK

(Gluconacetobacter
diazotrophicus) 		PF00148
(Oxidored_nitro)
PF11844
(DUF3364) 		4 GLU B 338
GLU B 342
TYR B 475
GLU B 340
 None
 1.44A 4mi4A-5kohB:
undetectable		 4mi4A-5kohB:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ku1 MITOCHONDRIAL RHO
GTPASE 1

(Homo sapiens) 		PF08355
(EF_assoc_1)
PF08356
(EF_assoc_2) 		4 ASN A 500
GLU A 537
GLU A 505
TYR A 506
 None
 1.08A 4mi4A-5ku1A:
undetectable		 4mi4A-5ku1A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nny WIPB

(Legionella
pneumophila) 		no annotation 4 ASN A 165
GLU A 157
GLU A 160
GLU A 164
 None
 1.31A 4mi4A-5nnyA:
undetectable		 4mi4A-5nnyA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ti8 AMINOTRANSFERASE

(Pseudomonas sp.
M1) 		PF00202
(Aminotran_3) 		4 GLU A 343
GLU A 344
GLU A 336
GLU A  72
 None
 1.34A 4mi4A-5ti8A:
undetectable		 4mi4A-5ti8A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tu9 ACCUMULATION
ASSOCIATED PROTEIN
AAP G58-SPACER-G513
(VARIANT
G5-SPACER-CONSENSUS
G5)

(Staphylococcus
epidermidis) 		PF07501
(G5)
PF17041
(SasG_E) 		4 ASN A  21
GLU A  28
GLU A  29
GLU A  75
 None
 0.94A 4mi4A-5tu9A:
undetectable		 4mi4A-5tu9A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vdk WEE1-LIKE PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 ASN A 252
GLU A 249
GLU A 253
GLU A 393
 None
 1.40A 4mi4A-5vdkA:
undetectable		 4mi4A-5vdkA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ve8 KAP123

(Kluyveromyces
lactis) 		no annotation 4 GLU A 626
GLU A 629
TYR A 703
GLU A 701
 None
 1.40A 4mi4A-5ve8A:
undetectable		 4mi4A-5ve8A:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4u DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3

(Saccharomyces
cerevisiae) 		no annotation 4 ASN C 206
GLU C 177
TYR C 180
GLU C 179
 None
 1.28A 4mi4A-5w4uC:
undetectable		 4mi4A-5w4uC:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1

(Homo sapiens) 		PF00400
(WD40)
PF00931
(NB-ARC) 		4 ASN A 485
TYR A 489
GLU A 525
GLU A 528
 None
 1.42A 4mi4A-5wveA:
undetectable		 4mi4A-5wveA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjq GEM-ASSOCIATED
PROTEIN 2

(Homo sapiens) 		no annotation 4 ASN 2 200
GLU 2 204
GLU 2 141
GLU 2 142
 None
 1.23A 4mi4A-5xjq2:
undetectable		 4mi4A-5xjq2:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjs GEM-ASSOCIATED
PROTEIN 2

(Homo sapiens) 		no annotation 4 ASN 2 200
GLU 2 204
GLU 2 141
GLU 2 142
 None
 1.14A 4mi4A-5xjs2:
undetectable		 4mi4A-5xjs2:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yud BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 1E

(Mus musculus) 		no annotation 4 ASN A 976
GLU A 969
TYR A 974
GLU A 975
 None
 1.16A 4mi4A-5yudA:
undetectable		 4mi4A-5yudA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cdd NPL4 ZINC FINGER

(Chaetomium
thermophilum) 		no annotation 4 GLU A 516
GLU A 520
GLU A 513
GLU A 309
 None
 1.25A 4mi4A-6cddA:
undetectable		 4mi4A-6cddA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cv9 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 6

(Mus musculus) 		no annotation 4 ASN A 904
GLU A 900
GLU A 899
GLU A 906
 None
 1.38A 4mi4A-6cv9A:
undetectable		 4mi4A-6cv9A:
20.11