SIMILAR PATTERNS OF AMINO ACIDS FOR 4MGH_A_ACTA1322_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b1y PROTEIN
(BETA-AMYLASE)

(Hordeum vulgare) 		PF01373
(Glyco_hydro_14) 		4 GLU A 378
THR A 415
GLU A 176
LYS A 293
 BGC  A 551 (-3.3A)
None
None
BGC  A 551 (-3.2A)
 1.28A 4mghA-1b1yA:
0.4		 4mghA-1b1yA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dl2 CLASS I
ALPHA-1,2-MANNOSIDAS
E

(Saccharomyces
cerevisiae) 		PF01532
(Glyco_hydro_47) 		4 GLU A 290
THR A 545
GLU A 232
LYS A 216
 None
 1.28A 4mghA-1dl2A:
0.0		 4mghA-1dl2A:
16.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3umm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE

(Salmonella
enterica) 		PF02769
(AIRS_C)
PF13507
(GATase_5) 		4 GLU A 648
THR A 650
GLU A1005
LYS A1009
 None
 0.30A 4mghA-3ummA:
62.7		 4mghA-3ummA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iqf METHIONYL-TRNA
FORMYLTRANSFERASE

(Bacillus
anthracis) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		4 GLU A 114
THR A 200
GLU A 127
LYS A 129
 None
None
PG5  A 401 (-4.8A)
None
 1.09A 4mghA-4iqfA:
0.0		 4mghA-4iqfA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bqz HEMAGGLUTININ HA1
CHAIN

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 GLU A  81
THR A  56
GLU A  58
LYS A 102
 None
 1.42A 4mghA-5bqzA:
0.0		 4mghA-5bqzA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlk ACETYL-COA
CARBOXYLASE

(Mycobacterium
tuberculosis) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 GLU A 285
THR A 283
GLU A 306
LYS A 247
 None
 1.44A 4mghA-5mlkA:
0.0		 4mghA-5mlkA:
20.93