SIMILAR PATTERNS OF AMINO ACIDS FOR 4MGH_A_ACTA1320_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5z L-LACTATE
DEHYDROGENASE

(Thermotoga
maritima) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 VAL A 289
LEU A 275
ILE A 302
LEU A 303
 None
 0.71A 4mghA-1a5zA:
0.0		 4mghA-1a5zA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6d THERMOSOME (ALPHA
SUBUNIT)

(Thermoplasma
acidophilum) 		PF00118
(Cpn60_TCP1) 		4 VAL A 199
LEU A 388
ILE A 373
LEU A 372
 None
 0.86A 4mghA-1a6dA:
0.0		 4mghA-1a6dA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1at0 17-HEDGEHOG

(Drosophila
melanogaster) 		PF01079
(Hint) 		4 VAL A 382
LEU A 306
LEU A 278
ARG A 304
 None
 0.79A 4mghA-1at0A:
undetectable		 4mghA-1at0A:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dm0 SHIGA TOXIN A
SUBUNIT

(Shigella
dysenteriae) 		PF00161
(RIP) 		4 VAL A  82
ILE A  70
LEU A  69
ARG A  68
 None
 0.75A 4mghA-1dm0A:
0.0		 4mghA-1dm0A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h81 POLYAMINE OXIDASE

(Zea mays) 		PF01593
(Amino_oxidase) 		4 LEU A 217
ILE A  33
LEU A  32
ARG A 230
 None
 0.88A 4mghA-1h81A:
0.0		 4mghA-1h81A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hp1 5'-NUCLEOTIDASE

(Escherichia
coli) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		4 VAL A 167
LEU A  78
ILE A 165
LEU A 157
 None
 0.87A 4mghA-1hp1A:
0.0		 4mghA-1hp1A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyh L-2-HYDROXYISOCAPROA
TE DEHYDROGENASE

(Weissella
confusa) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 VAL A 147
LEU A 115
ILE A 325
ARG A 321
 None
 0.83A 4mghA-1hyhA:
3.0		 4mghA-1hyhA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1inp INOSITOL
POLYPHOSPHATE
1-PHOSPHATASE

(Bos taurus) 		PF00459
(Inositol_P) 		4 VAL A 188
LEU A 148
ILE A   4
LEU A   5
 None
 0.86A 4mghA-1inpA:
0.0		 4mghA-1inpA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ldn L-LACTATE
DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 VAL A 215
LEU A 226
ILE A 211
ARG A 212
 None
 0.87A 4mghA-1ldnA:
0.0		 4mghA-1ldnA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oa1 HYDROXYLAMINE
REDUCTASE

(Desulfovibrio
vulgaris) 		PF03063
(Prismane) 		4 VAL A 263
LEU A 252
ILE A 241
LEU A 240
 None
 0.84A 4mghA-1oa1A:
undetectable		 4mghA-1oa1A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ovm INDOLE-3-PYRUVATE
DECARBOXYLASE

(Enterobacter
cloacae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 VAL A 283
LEU A 229
ILE A 328
LEU A 331
 None
 0.84A 4mghA-1ovmA:
undetectable		 4mghA-1ovmA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgu ACTIN INTERACTING
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 VAL A 599
LEU A 350
ILE A 607
ARG A 609
 None
 0.67A 4mghA-1pguA:
undetectable		 4mghA-1pguA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qcw FLAVOCYTOCHROME B2

(Saccharomyces
cerevisiae) 		PF01070
(FMN_dh) 		4 VAL A 190
ILE A 451
LEU A 454
ARG A 455
 None
 0.87A 4mghA-1qcwA:
undetectable		 4mghA-1qcwA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4p SHIGA-LIKE TOXIN
TYPE II A SUBUNIT

(Escherichia
coli) 		PF00161
(RIP) 		4 VAL A  82
ILE A  70
LEU A  69
ARG A  68
 None
 0.82A 4mghA-1r4pA:
undetectable		 4mghA-1r4pA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sg9 HEMK PROTEIN

(Thermotoga
maritima) 		PF05175
(MTS) 		4 VAL A  40
LEU A  51
ILE A  14
LEU A  17
 None
 0.84A 4mghA-1sg9A:
undetectable		 4mghA-1sg9A:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u00 CHAPERONE PROTEIN
HSCA

(Escherichia
coli) 		PF00012
(HSP70) 		4 VAL A 471
LEU A 398
ILE A 435
LEU A 456
 None
 0.86A 4mghA-1u00A:
undetectable		 4mghA-1u00A:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1upx HYDROXYLAMINE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF03063
(Prismane) 		4 VAL A 259
LEU A 248
ILE A 237
LEU A 236
 None
 0.82A 4mghA-1upxA:
undetectable		 4mghA-1upxA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uxi MALATE DEHYDROGENASE

(Chloroflexus
aurantiacus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 VAL A 267
LEU A 254
ILE A 279
LEU A 280
 None
 0.81A 4mghA-1uxiA:
2.7		 4mghA-1uxiA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wgd HOMOCYSTEINE-RESPONS
IVE ENDOPLASMIC
RETICULUM-RESIDENT
UBIQUITIN-LIKE
DOMAIN MEMBER 1
PROTEIN

(Homo sapiens) 		PF00240
(ubiquitin) 		4 VAL A  83
ILE A  55
LEU A  54
ARG A  53
 None
 0.83A 4mghA-1wgdA:
undetectable		 4mghA-1wgdA:
5.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yhn RAS-RELATED PROTEIN
RAB-7

(Homo sapiens) 		PF00071
(Ras) 		4 VAL A  52
LEU A 174
LEU A  56
ARG A  55
 None
 0.74A 4mghA-1yhnA:
3.2		 4mghA-1yhnA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yx5 UBIQUITIN

(Homo sapiens) 		PF00240
(ubiquitin) 		4 VAL B  26
LEU B  56
ILE B   3
LEU B  15
 None
 0.84A 4mghA-1yx5B:
undetectable		 4mghA-1yx5B:
5.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfz SDS HYDROLASE SDSA1

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		4 LEU A 264
ILE A 257
LEU A 256
ARG A 255
 None
 0.70A 4mghA-2cfzA:
undetectable		 4mghA-2cfzA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ci6 NG,
NG-DIMETHYLARGININE
DIMETHYLAMINOHYDROLA
SE 1

(Bos taurus) 		PF02274
(Amidinotransf) 		4 VAL A  16
LEU A 108
ILE A 278
LEU A 277
 None
 0.85A 4mghA-2ci6A:
undetectable		 4mghA-2ci6A:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cyu 2-OXOGLUTARATE
DEHYDROGENASE
MULTIENZYME COMPLEX

(Escherichia
coli) 		PF02817
(E3_binding) 		4 VAL A  34
LEU A  29
ILE A   6
LEU A   9
 None
 0.73A 4mghA-2cyuA:
undetectable		 4mghA-2cyuA:
3.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eer NAD-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 VAL A 132
LEU A 138
ILE A  30
LEU A  29
 None
 0.83A 4mghA-2eerA:
3.1		 4mghA-2eerA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2enq PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT ALPHA
ISOFORM

(Homo sapiens) 		PF00792
(PI3K_C2) 		4 VAL A  33
LEU A 150
ILE A  15
LEU A  64
 None
 0.85A 4mghA-2enqA:
undetectable		 4mghA-2enqA:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gno DNA POLYMERASE III,
GAMMA
SUBUNIT-RELATED
PROTEIN

(Thermotoga
maritima) 		PF13177
(DNA_pol3_delta2) 		4 VAL A 143
LEU A  16
ILE A  28
LEU A  29
 None
 0.85A 4mghA-2gnoA:
undetectable		 4mghA-2gnoA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gow UBIQUITIN-LIKE
PROTEIN 3

(Homo sapiens) 		PF13881
(Rad60-SLD_2) 		4 VAL A  85
ILE A  15
LEU A  14
ARG A  13
 None
 0.83A 4mghA-2gowA:
undetectable		 4mghA-2gowA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h6e D-ARABINOSE
1-DEHYDROGENASE

(Sulfolobus
solfataricus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 VAL A 128
LEU A 134
ILE A  33
LEU A  32
 None
 0.87A 4mghA-2h6eA:
2.2		 4mghA-2h6eA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i4n PROLINE-TRNA LIGASE

(Rhodopseudomonas
palustris) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		4 LEU A 396
ILE A  10
LEU A  11
ARG A  28
 None
 0.83A 4mghA-2i4nA:
undetectable		 4mghA-2i4nA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ihy ABC TRANSPORTER,
ATP-BINDING PROTEIN

(Staphylococcus
aureus) 		PF00005
(ABC_tran) 		4 VAL A 200
LEU A  45
ILE A 165
LEU A 166
 None
 0.83A 4mghA-2ihyA:
undetectable		 4mghA-2ihyA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocp DEOXYGUANOSINE
KINASE

(Homo sapiens) 		PF01712
(dNK) 		4 VAL A 144
LEU A 177
ILE A 184
LEU A 186
 None
 0.87A 4mghA-2ocpA:
undetectable		 4mghA-2ocpA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6r AFUHEL308 HELICASE

(Archaeoglobus
fulgidus) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 VAL A 459
LEU A 434
ILE A 423
LEU A 420
 None
 0.82A 4mghA-2p6rA:
undetectable		 4mghA-2p6rA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phc UNCHARACTERIZED
PROTEIN PH0987

(Pyrococcus
horikoshii) 		PF02682
(CT_C_D) 		4 VAL B  54
LEU B  70
ILE B  13
LEU B  12
 None
 0.85A 4mghA-2phcB:
undetectable		 4mghA-2phcB:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjr PROTEIN (HELICASE
PCRA)

(Geobacillus
stearothermophilus) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		4 VAL A  97
LEU A 540
ILE A 115
LEU A 190
 None
 0.60A 4mghA-2pjrA:
undetectable		 4mghA-2pjrA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pr7 HALOACID
DEHALOGENASE/EPOXIDE
HYDROLASE FAMILY

(Corynebacterium
glutamicum) 		PF00702
(Hydrolase) 		5 VAL A  63
LEU A  65
ILE A  51
LEU A  54
ARG A  52
 None
None
None
EDO  A 138 ( 4.8A)
None
 1.31A 4mghA-2pr7A:
undetectable		 4mghA-2pr7A:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkx BIFUNCTIONAL PROTEIN
GLMU

(Mycobacterium
tuberculosis) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		4 LEU A 100
ILE A  53
LEU A  52
ARG A  51
 None
 0.81A 4mghA-2qkxA:
undetectable		 4mghA-2qkxA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rau PUTATIVE ESTERASE

(Sulfolobus
solfataricus) 		PF12146
(Hydrolase_4) 		4 VAL A  52
LEU A 349
ILE A 173
LEU A 147
 None
 0.88A 4mghA-2rauA:
undetectable		 4mghA-2rauA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rop COPPER-TRANSPORTING
ATPASE 2

(Homo sapiens) 		PF00403
(HMA) 		4 VAL A 164
LEU A 176
ILE A 126
LEU A 125
 None
 0.80A 4mghA-2ropA:
undetectable		 4mghA-2ropA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vw8 PA1000

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B) 		4 VAL A  90
LEU A  78
ILE A  67
LEU A  66
 None
 0.79A 4mghA-2vw8A:
undetectable		 4mghA-2vw8A:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w59 IGY FCU3-4

(Gallus gallus) 		PF07654
(C1-set) 		4 VAL A 374
LEU A 377
ILE A 350
LEU A 442
 None
 0.82A 4mghA-2w59A:
undetectable		 4mghA-2w59A:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wkp NPH1-1, RAS-RELATED
C3 BOTULINUM TOXIN
SUBSTRATE 1

(Avena sativa;
Homo sapiens) 		PF00071
(Ras)
PF13426
(PAS_9) 		4 VAL A 594
LEU A 720
ILE A 547
LEU A 546
 None
 0.87A 4mghA-2wkpA:
3.5		 4mghA-2wkpA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x8w METHYLGLYOXAL
SYNTHASE

(Thermus sp. GH5) 		PF02142
(MGS) 		4 VAL A  76
LEU A  95
ILE A   7
LEU A   6
 None
 0.87A 4mghA-2x8wA:
2.9		 4mghA-2x8wA:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xgg MICRONEME PROTEIN 2

(Toxoplasma
gondii) 		PF00092
(VWA) 		4 VAL A 117
LEU A  99
ILE A  81
LEU A  80
 None
 0.83A 4mghA-2xggA:
undetectable		 4mghA-2xggA:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y5c ADRENODOXIN-LIKE
PROTEIN,
MITOCHONDRIAL

(Homo sapiens) 		PF00111
(Fer2) 		4 VAL A  56
LEU A  64
ILE A  91
ARG A  86
 None
 0.87A 4mghA-2y5cA:
undetectable		 4mghA-2y5cA:
6.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aoe GLUTAMATE
DEHYDROGENASE

(Thermus
thermophilus) 		no annotation 4 LEU E 150
ILE E 143
LEU E 142
ARG E  66
 None
 0.83A 4mghA-3aoeE:
3.0		 4mghA-3aoeE:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clh 3-DEHYDROQUINATE
SYNTHASE

(Helicobacter
pylori) 		PF01761
(DHQ_synthase) 		4 VAL A  54
LEU A  49
ILE A  31
LEU A  30
 None
 0.80A 4mghA-3clhA:
undetectable		 4mghA-3clhA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dj4 BIFUNCTIONAL PROTEIN
GLMU

(Mycobacterium
tuberculosis) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		4 LEU A 100
ILE A  53
LEU A  52
ARG A  51
 None
 0.85A 4mghA-3dj4A:
undetectable		 4mghA-3dj4A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3e UNCHARACTERIZED
PROTEIN TM1679

(Thermotoga
maritima) 		PF00753
(Lactamase_B) 		4 VAL A  74
LEU A  66
ILE A  55
LEU A  54
 None
 0.81A 4mghA-3h3eA:
undetectable		 4mghA-3h3eA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hsa PLECKSTRIN HOMOLOGY
DOMAIN

(Shewanella
amazonensis) 		PF08000
(bPH_1) 		4 VAL A  45
LEU A  23
ILE A  54
LEU A  53
 None
None
None
MLY  A 104 ( 4.8A)
 0.87A 4mghA-3hsaA:
undetectable		 4mghA-3hsaA:
6.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ju8 SUCCINYLGLUTAMIC
SEMIALDEHYDE
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00171
(Aldedh) 		4 VAL A 385
LEU A 297
ILE A 364
LEU A 365
 None
 0.67A 4mghA-3ju8A:
undetectable		 4mghA-3ju8A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jux PROTEIN TRANSLOCASE
SUBUNIT SECA

(Thermotoga
maritima) 		PF00271
(Helicase_C)
PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		4 VAL A 813
LEU A 672
ILE A 750
LEU A 753
 None
 0.87A 4mghA-3juxA:
undetectable		 4mghA-3juxA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldf PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.776

(Streptococcus
mutans) 		PF10672
(Methyltrans_SAM) 		4 VAL A 385
LEU A 318
ILE A 327
LEU A 326
 None
 0.83A 4mghA-3ldfA:
undetectable		 4mghA-3ldfA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lou FORMYLTETRAHYDROFOLA
TE DEFORMYLASE

(Burkholderia
mallei) 		PF00551
(Formyl_trans_N) 		4 VAL A 247
LEU A 256
ILE A 223
LEU A 222
 None
 0.76A 4mghA-3louA:
undetectable		 4mghA-3louA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mop INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4

(Homo sapiens) 		no annotation 4 VAL G  81
LEU G  14
ILE G   5
LEU G 101
 None
 0.88A 4mghA-3mopG:
undetectable		 4mghA-3mopG:
6.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oet ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE

(Salmonella
enterica) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
PF11890
(DUF3410) 		4 VAL A 170
LEU A 103
ILE A 204
LEU A 203
 None
 0.80A 4mghA-3oetA:
3.3		 4mghA-3oetA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qdn PUTATIVE THIOREDOXIN
PROTEIN

(Salmonella
enterica) 		PF00085
(Thioredoxin)
PF14559
(TPR_19)
PF14561
(TPR_20) 		4 VAL A  81
LEU A  45
ILE A 102
LEU A 105
 None
 0.86A 4mghA-3qdnA:
undetectable		 4mghA-3qdnA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slk POLYKETIDE SYNTHASE
EXTENDER MODULE 2

(Saccharopolyspora
spinosa) 		PF08240
(ADH_N)
PF08659
(KR)
PF13602
(ADH_zinc_N_2) 		4 VAL A  56
LEU A 154
LEU A  96
ARG A  95
 None
 0.88A 4mghA-3slkA:
3.1		 4mghA-3slkA:
22.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3umm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE

(Salmonella
enterica) 		PF02769
(AIRS_C)
PF13507
(GATase_5) 		5 VAL A 438
LEU A 508
ILE A 530
LEU A 531
ARG A 550
 None
 0.28A 4mghA-3ummA:
62.7		 4mghA-3ummA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zfv CRISPR-ASSOCIATED
ENDORIBONUCLEASE
CAS6 1

(Sulfolobus
solfataricus) 		PF10040
(CRISPR_Cas6) 		4 VAL A 121
LEU A 187
ILE A   4
LEU A   3
 None
 0.83A 4mghA-3zfvA:
undetectable		 4mghA-3zfvA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvq GLUTAMATE-PYRUVATE
AMINOTRANSFERASE
ALAA

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		4 LEU A 115
ILE A 203
LEU A 202
ARG A 170
 None
 0.80A 4mghA-4cvqA:
2.0		 4mghA-4cvqA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dpk MALONYL-COA/SUCCINYL
-COA REDUCTASE

(Sulfurisphaera
tokodaii) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 VAL A 148
LEU A 351
ILE A 131
LEU A 133
 None
 0.84A 4mghA-4dpkA:
2.4		 4mghA-4dpkA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g2n D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE,
NAD-BINDING

(Polaromonas sp.
JS666) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 VAL A 238
LEU A 224
ILE A 212
LEU A 211
 None
 0.84A 4mghA-4g2nA:
3.8		 4mghA-4g2nA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gsw UBIQUITIN

(Entamoeba
histolytica) 		PF00240
(ubiquitin) 		4 VAL A  73
ILE A  47
LEU A  46
ARG A  45
 None
 0.87A 4mghA-4gswA:
undetectable		 4mghA-4gswA:
5.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h63 MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 17

(Schizosaccharomyces
pombe) 		PF10156
(Med17) 		4 VAL Q 326
LEU Q 425
ILE Q 333
LEU Q 334
 None
 0.86A 4mghA-4h63Q:
undetectable		 4mghA-4h63Q:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kds PLASMINOGEN
ACTIVATOR INHIBITOR
1

(Oncorhynchus
mykiss) 		PF00079
(Serpin) 		4 VAL A 220
LEU A 267
ILE A 218
LEU A 230
 None
 0.86A 4mghA-4kdsA:
undetectable		 4mghA-4kdsA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l0c DEFORMYLASE

(Pseudomonas
putida) 		PF12697
(Abhydrolase_6) 		4 VAL A  90
LEU A  78
ILE A  28
LEU A  27
 None
 0.77A 4mghA-4l0cA:
undetectable		 4mghA-4l0cA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0p RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE 1

(Homo sapiens) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		4 VAL A 168
LEU A 236
ILE A 192
LEU A 191
 None
 0.78A 4mghA-4m0pA:
2.6		 4mghA-4m0pA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mj7 RRNA-PROCESSING
PROTEIN UTP23

(Saccharomyces
cerevisiae) 		PF04900
(Fcf1) 		4 VAL A 118
LEU A  53
ILE A 139
LEU A 138
 None
 0.60A 4mghA-4mj7A:
undetectable		 4mghA-4mj7A:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8q COATOMER SUBUNIT
DELTA

(Bos taurus) 		PF00928
(Adap_comp_sub) 		4 VAL A 317
LEU A 362
ILE A 344
LEU A 343
 None
 0.82A 4mghA-4o8qA:
undetectable		 4mghA-4o8qA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofy PROTEIN SYG-2

(Caenorhabditis
elegans) 		PF08205
(C2-set_2)
PF13927
(Ig_3) 		4 VAL D 252
LEU D 246
ILE D 239
LEU D 240
 None
 0.85A 4mghA-4ofyD:
undetectable		 4mghA-4ofyD:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfb C4-DICARBOXYLATE-BIN
DING PROTEIN

(Fusobacterium
nucleatum) 		PF03480
(DctP) 		4 VAL A 138
LEU A  93
ILE A 136
LEU A 132
 None
 0.76A 4mghA-4pfbA:
undetectable		 4mghA-4pfbA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pqg GLYCOSYLTRANSFERASE
GTF1

(Streptococcus
pneumoniae) 		PF00534
(Glycos_transf_1) 		4 VAL A 396
LEU A 464
ILE A 421
LEU A 420
 None
 0.81A 4mghA-4pqgA:
undetectable		 4mghA-4pqgA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztc AMINOTRANSFERASE
HOMOLOG

(Campylobacter
jejuni) 		PF01041
(DegT_DnrJ_EryC1) 		4 VAL A  75
LEU A  64
ILE A 127
LEU A 126
 None
 0.85A 4mghA-4ztcA:
undetectable		 4mghA-4ztcA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zu9 ELONGATION FACTOR
SELB

(Aquifex
aeolicus) 		PF00009
(GTP_EFTU)
PF09107
(SelB-wing_3) 		4 VAL A 184
LEU A 197
ILE A 260
LEU A 259
 None
 0.86A 4mghA-4zu9A:
3.1		 4mghA-4zu9A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5agt LEUCINE--TRNA LIGASE

(Mycobacterium
tuberculosis) 		PF13603
(tRNA-synt_1_2) 		4 VAL A 334
LEU A 348
ILE A 332
LEU A 317
 None
 0.81A 4mghA-5agtA:
undetectable		 4mghA-5agtA:
11.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5al7 SPINDLE ASSEMBLY
ABNORMAL PROTEIN 6
HOMOLOG

(Drosophila
melanogaster) 		PF16531
(SAS-6_N) 		4 VAL A 101
LEU A  58
ILE A  23
LEU A  24
 None
 0.79A 4mghA-5al7A:
undetectable		 4mghA-5al7A:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b83 TETRA UBIQUITIN

(Homo sapiens) 		PF00240
(ubiquitin) 		4 VAL A 146
ILE A 120
LEU A 119
ARG A 118
 None
 0.78A 4mghA-5b83A:
undetectable		 4mghA-5b83A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ck3 PUTATIVE SIGNAL
RECOGNITION PARTICLE
PROTEIN

(Chaetomium
thermophilum) 		PF09439
(SRPRB) 		4 VAL B 196
LEU B 161
ILE B  56
LEU B  55
 None
 0.82A 4mghA-5ck3B:
2.8		 4mghA-5ck3B:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlq EXPORTIN-4

(Mus musculus) 		no annotation 4 VAL B 119
LEU B  98
ILE B 159
ARG B  94
 None
 0.79A 4mghA-5dlqB:
undetectable		 4mghA-5dlqB:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h07 POLYUBIQUITIN-C

(Homo sapiens) 		PF00240
(ubiquitin) 		4 VAL A 170
ILE A 144
LEU A 143
ARG A 142
 None
 0.88A 4mghA-5h07A:
undetectable		 4mghA-5h07A:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzr SNF2-FAMILY ATP
DEPENDENT CHROMATIN
REMODELING FACTOR
LIKE PROTEIN

(Thermothelomyces
thermophila) 		PF00176
(SNF2_N)
PF00271
(Helicase_C)
PF14619
(SnAC) 		5 VAL A 797
LEU A1008
ILE A 998
LEU A 997
ARG A 996
 None
 1.24A 4mghA-5hzrA:
undetectable		 4mghA-5hzrA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5in8 ARISTOLOCHENE
SYNTHASE

(Aspergillus
terreus) 		no annotation 4 VAL A 118
LEU A 102
ILE A  83
LEU A  86
 None
 0.69A 4mghA-5in8A:
undetectable		 4mghA-5in8A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n06 TYROSINE-PROTEIN
KINASE RECEPTOR
TIE-1

(Homo sapiens) 		PF00041
(fn3) 		4 VAL A 681
LEU A 708
ILE A 660
LEU A 662
 None
 0.86A 4mghA-5n06A:
undetectable		 4mghA-5n06A:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5och -

(-) 		no annotation 4 VAL B 551
LEU B 520
ILE B 634
LEU B 633
 None
 0.69A 4mghA-5ochB:
undetectable		 4mghA-5ochB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqm GENERAL
TRANSCRIPTION AND
DNA REPAIR FACTOR
IIH HELICASE SUBUNIT
XPB

(Saccharomyces
cerevisiae) 		no annotation 4 VAL 7 493
LEU 7 487
ILE 7 531
LEU 7 530
 None
 0.85A 4mghA-5oqm7:
2.4		 4mghA-5oqm7:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t98 GLYCOSIDE HYDROLASE

(Bacteroides
uniformis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		4 VAL A 654
LEU A 713
ILE A 640
LEU A 641
 None
 0.77A 4mghA-5t98A:
undetectable		 4mghA-5t98A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tx7 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN

(Desulfovibrio
vulgaris) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 VAL A 203
LEU A 110
ILE A 233
LEU A 232
 None
 0.84A 4mghA-5tx7A:
3.7		 4mghA-5tx7A:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v5g UBIQUITIN VARIANT
CC.4

(synthetic
construct) 		PF00240
(ubiquitin) 		4 VAL B  70
ILE B  44
LEU B  43
ARG B  42
 None
 0.81A 4mghA-5v5gB:
undetectable		 4mghA-5v5gB:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ve3 BPPRF

(Paraburkholderia
phytofirmans) 		no annotation 5 VAL B 271
LEU B 304
ILE B 292
LEU B 291
ARG B 290
 None
 1.16A 4mghA-5ve3B:
undetectable		 4mghA-5ve3B:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wyr TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Pseudomonas
aeruginosa) 		no annotation 4 VAL A  89
LEU A  75
ILE A 116
LEU A 115
 None
 0.87A 4mghA-5wyrA:
undetectable		 4mghA-5wyrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnl OXYGEN-EVOLVING
ENHANCER PROTEIN 2,
CHLOROPLASTIC

(Pisum sativum) 		PF01789
(PsbP) 		4 VAL P 131
LEU P  81
ILE P 129
LEU P 146
 None
 0.87A 4mghA-5xnlP:
undetectable		 4mghA-5xnlP:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyj ACETYL-COA
ACETYLTRANSFERASE

(Saccharomyces
cerevisiae) 		no annotation 4 VAL B 112
LEU B  45
ILE B 262
LEU B 263
 None
 0.83A 4mghA-5xyjB:
undetectable		 4mghA-5xyjB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y89 PUTATIVE HEMIN
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN

(Burkholderia
cenocepacia) 		no annotation 4 VAL A 274
LEU A 257
ILE A 243
LEU A 242
 None
 0.82A 4mghA-5y89A:
3.6		 4mghA-5y89A:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z2m -

(-) 		no annotation 4 VAL A  52
LEU A 174
LEU A  56
ARG A  55
 None
 0.88A 4mghA-5z2mA:
3.3		 4mghA-5z2mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a31 PEPTIDYL-TRNA
HYDROLASE

(Acinetobacter
baumannii) 		no annotation 4 LEU A 118
ILE A  92
LEU A  91
ARG A 131
 None
 0.78A 4mghA-6a31A:
undetectable		 4mghA-6a31A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cdw EFFECTOR PROTEIN
LEM4 (LPG1101)

(Legionella
pneumophila) 		no annotation 4 VAL A 178
LEU A 169
ILE A 154
LEU A 153
 None
 0.85A 4mghA-6cdwA:
undetectable		 4mghA-6cdwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dus TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN

(Salmonella
enterica) 		no annotation 4 VAL A 246
LEU A 296
ILE A 244
LEU A 240
 None
 0.75A 4mghA-6dusA:
undetectable		 4mghA-6dusA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f1v CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		no annotation 4 VAL f 665
LEU f 682
ILE f 609
LEU f 608
 None
 0.78A 4mghA-6f1vf:
undetectable		 4mghA-6f1vf:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fj7 -

(-) 		no annotation 4 VAL A  28
LEU A  58
ILE A   3
LEU A  17
 None
 0.86A 4mghA-6fj7A:
undetectable		 4mghA-6fj7A:
undetectable