SIMILAR PATTERNS OF AMINO ACIDS FOR 4MFQ_B_GCSB503_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ftg APOFLAVODOXIN

(Nostoc sp. PCC
7119) 		PF00258
(Flavodoxin_1) 		4 GLN A 162
TRP A 159
ALA A  84
PHE A  26
 None
 1.32A 4mfqA-1ftgA:
0.0		 4mfqA-1ftgA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wmr ISOPULLULANASE

(Aspergillus
niger) 		PF03718
(Glyco_hydro_49)
PF17433
(Glyco_hydro_49N) 		4 GLN A 172
TRP A 390
ALA A 176
PHE A 348
 None
 1.39A 4mfqA-1wmrA:
0.0		 4mfqA-1wmrA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x55 ASPARAGINYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 TRP A 148
TRP A 154
ALA A 231
PHE A 402
 None
 1.17A 4mfqA-1x55A:
0.0		 4mfqA-1x55A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3men ACETYLPOLYAMINE
AMINOHYDROLASE

(Burkholderia
pseudomallei) 		PF00850
(Hist_deacetyl) 		4 MET A  80
TRP A  84
TRP A  77
ALA A 107
 None
 1.48A 4mfqA-3menA:
0.0		 4mfqA-3menA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3usz EXO-1,3/1,4-BETA-GLU
CANASE

(Pseudoalteromonas
sp. BB1) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		4 GLN A  40
MET A  32
ALA A  92
PHE A 363
 None
 1.49A 4mfqA-3uszA:
0.0		 4mfqA-3uszA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdo MFS TRANSPORTER

(Escherichia
coli) 		PF07690
(MFS_1) 		4 GLN A  61
MET A  28
ALA A 117
PHE A 144
 None
 1.37A 4mfqA-3wdoA:
0.0		 4mfqA-3wdoA:
22.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4q38 PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24

(Actinoplanes
teichomyceticus) 		no annotation 5 GLN A 142
MET A 161
TRP A 163
TRP A 164
PHE A 281
 TEC  A 404 ( 4.0A)
TEC  A 404 (-4.3A)
TEC  A 404 (-4.6A)
TEC  A 404 (-3.7A)
COA  A 403 (-3.4A)
 0.73A 4mfqA-4q38A:
50.8		 4mfqA-4q38A:
97.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jgj UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE

(Aspergillus
fumigatus) 		PF01209
(Ubie_methyltran) 		4 GLN A 130
TRP A 162
TRP A 157
ALA A 279
 None
 1.08A 4mfqA-5jgjA:
0.0		 4mfqA-5jgjA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkf POLYCYSTIN-2

(Homo sapiens) 		PF08016
(PKD_channel) 		4 GLN A 323
TRP A 280
TRP A 414
ALA A 365
 None
 1.39A 4mfqA-5mkfA:
0.0		 4mfqA-5mkfA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MBH13 NADH
DEHYDROGENASE
SUBUNIT

(Pyrococcus
furiosus) 		no annotation 4 MET M 144
TRP M 195
ALA M 247
PHE M 103
 None
 1.07A 4mfqA-6cfwM:
undetectable		 4mfqA-6cfwM:
13.41