SIMILAR PATTERNS OF AMINO ACIDS FOR 4MF6_A_BEZA303
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b8g | PROTEIN(1-AMINOCYCLOPROPANE-1-CARBOXYLATESYNTHASE) (Malus domestica) |
PF00155(Aminotran_1_2) | 4 | THR A 236PHE A 98ASN A 330TYR A 326 | None | 1.22A | 4mf6A-1b8gA:0.0 | 4mf6A-1b8gA:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bqc | PROTEIN(BETA-MANNANASE) (Thermobifidafusca) |
PF00150(Cellulase) | 4 | THR A 174PHE A 214ASN A 173TYR A 210 | None | 1.49A | 4mf6A-1bqcA:0.0 | 4mf6A-1bqcA:22.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1keh | PRECURSOR OFCEPHALOSPORINACYLASE (Brevundimonasdiminuta) |
PF01804(Penicil_amidase) | 4 | THR A 625PRO A 191PHE A 667ASN A 190 | None | 1.46A | 4mf6A-1kehA:undetectable | 4mf6A-1kehA:15.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x9e | HMG-COA SYNTHASE (Enterococcusfaecalis) |
PF01154(HMG_CoA_synt_N)PF08540(HMG_CoA_synt_C) | 4 | THR A 152PHE A 185ASN A 275TYR A 277 | NoneSO4 A 385 ( 3.9A)SO4 A 385 (-3.2A)SO4 A 385 (-4.7A) | 1.48A | 4mf6A-1x9eA:0.0 | 4mf6A-1x9eA:21.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zea | MONOCLONALANTI-CHOLERA TOXINIGG1 KAPPA ANTIBODY,H CHAIN (Mus musculus) |
PF07654(C1-set)PF07686(V-set) | 4 | THR H 13PRO H 14PHE H 146ASN H 84 | None | 1.28A | 4mf6A-1zeaH:undetectable | 4mf6A-1zeaH:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bpa | PROTEIN (SUBUNIT OFBACTERIOPHAGEPHIX174) (Escherichiavirus phiX174) |
PF02305(Phage_F) | 4 | THR 1 294PRO 1 293PHE 1 334ASN 1 167 | None | 1.50A | 4mf6A-2bpa1:0.0 | 4mf6A-2bpa1:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rii | SULFIREDOXIN-1 (Homo sapiens) |
PF02195(ParBc) | 4 | THR X 133PRO X 134PHE X 96TYR X 94 | None | 1.40A | 4mf6A-2riiX:undetectable | 4mf6A-2riiX:20.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x7x | SENSOR PROTEIN (Bacteroidesthetaiotaomicron) |
PF13407(Peripla_BP_4) | 4 | THR A 167PRO A 168ASN A 136TYR A 271 | NoneFRU A1335 (-4.4A)NoneFRU A1335 (-4.2A) | 1.38A | 4mf6A-2x7xA:undetectable | 4mf6A-2x7xA:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x98 | ALKALINE PHOSPHATASE (Halobacteriumsalinarum) |
PF00245(Alk_phosphatase) | 4 | THR A 164PRO A 173PHE A 210TYR A 193 | None | 1.40A | 4mf6A-2x98A:0.0 | 4mf6A-2x98A:20.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yhe | SEC-ALKYL SULFATASE (Pseudomonas sp.DSM 6611) |
PF00753(Lactamase_B)PF14863(Alkyl_sulf_dimr)PF14864(Alkyl_sulf_C) | 4 | PRO A 322PHE A 250ASN A 318TYR A 417 | NoneNoneSO4 A 801 (-3.8A)SO4 A 801 (-4.3A) | 1.36A | 4mf6A-2yheA:undetectable | 4mf6A-2yheA:17.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f1c | PUTATIVE2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATECYTIDYLYLTRANSFERASE2 (Listeriamonocytogenes) |
PF01128(IspD) | 4 | THR A 167PRO A 168PHE A 171ASN A 124 | None | 1.25A | 4mf6A-3f1cA:undetectable | 4mf6A-3f1cA:21.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fcy | XYLAN ESTERASE 1 (Thermoanaerobacteriumsaccharolyticum) |
PF05448(AXE1) | 4 | THR A 246PRO A 19PHE A 231ASN A 18 | None | 1.20A | 4mf6A-3fcyA:undetectable | 4mf6A-3fcyA:24.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fhh | OUTER MEMBRANE HEMERECEPTOR SHUA (Shigelladysenteriae) |
PF00593(TonB_dep_Rec)PF07715(Plug) | 4 | THR A 401PRO A 400PHE A 16ASN A 399 | None | 1.43A | 4mf6A-3fhhA:undetectable | 4mf6A-3fhhA:17.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s51 | FANCONI ANEMIA GROUPI PROTEIN HOMOLOG (Mus musculus) |
PF14674(FANCI_S1-cap)PF14675(FANCI_S1)PF14676(FANCI_S2)PF14677(FANCI_S3)PF14678(FANCI_S4)PF14679(FANCI_HD1)PF14680(FANCI_HD2) | 4 | THR A1194PRO A1192PHE A1177TYR A1181 | None | 1.38A | 4mf6A-3s51A:2.9 | 4mf6A-3s51A:10.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v8u | TRANSFERRINBINDING-PROTEIN B (Neisseriameningitidis) |
PF01298(TbpB_B_D)PF17483(TbpB_C)PF17484(TbpB_A) | 4 | THR A 243PHE A 132ASN A 124TYR A 103 | None | 1.50A | 4mf6A-3v8uA:undetectable | 4mf6A-3v8uA:16.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bj1 | PROTEIN RIF2 (Saccharomycescerevisiae) |
no annotation | 4 | THR A 298PHE A 74ASN A 310TYR A 309 | None | 1.32A | 4mf6A-4bj1A:undetectable | 4mf6A-4bj1A:20.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bj6 | RAP1-INTERACTINGFACTOR 2 (Saccharomycescerevisiae) |
no annotation | 4 | THR A 298PHE A 74ASN A 310TYR A 309 | None | 1.20A | 4mf6A-4bj6A:undetectable | 4mf6A-4bj6A:19.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cp6 | CHOLINE BINDINGPROTEIN PCPA (Streptococcuspneumoniae) |
PF13306(LRR_5) | 4 | THR A 282PRO A 279PHE A 290TYR A 276 | None | 1.21A | 4mf6A-4cp6A:undetectable | 4mf6A-4cp6A:18.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d65 | PORIN 2 (Providenciastuartii) |
PF00267(Porin_1) | 4 | THR A 132PHE A 54ASN A 94TYR A 78 | None | 1.50A | 4mf6A-4d65A:undetectable | 4mf6A-4d65A:21.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ecn | LEUCINE-RICH REPEATPROTEIN (Bacteroidesthetaiotaomicron) |
PF14660(DUF4458) | 4 | THR A 388PHE A 419ASN A 485TYR A 527 | None | 1.41A | 4mf6A-4ecnA:undetectable | 4mf6A-4ecnA:13.72 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ikh | GLUTATHIONES-TRANSFERASE (Pseudomonasprotegens) |
PF00043(GST_C)PF02798(GST_N) | 5 | THR A 28PRO A 29PHE A 139ASN A 192TYR A 197 | GSH A 301 (-3.4A)NoneNoneNoneNone | 0.34A | 4mf6A-4ikhA:36.3 | 4mf6A-4ikhA:68.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jis | RIBITOL-5-PHOSPHATECYTIDYLYLTRANSFERASE (Bacillussubtilis) |
PF01128(IspD) | 4 | THR A 168PRO A 169PHE A 172ASN A 125 | None | 1.26A | 4mf6A-4jisA:undetectable | 4mf6A-4jisA:19.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m9x | CELL DEATH PROTEIN 4 (Caenorhabditiselegans) |
PF00619(CARD)PF00931(NB-ARC) | 4 | THR A 367PRO A 368PHE A 301TYR A 305 | ATP A 602 (-4.4A)ATP A 602 (-3.9A)ATP A 602 (-4.5A)None | 1.31A | 4mf6A-4m9xA:undetectable | 4mf6A-4m9xA:17.08 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4mf6 | GLUTATHIONES-TRANSFERASE DOMAIN (Paraburkholderiagraminis) |
PF00043(GST_C)PF02798(GST_N) | 5 | THR A 28PRO A 29PHE A 139ASN A 192TYR A 197 | GSH A 301 (-3.3A)GSH A 302 ( 4.4A)BEZ A 303 (-3.4A)BEZ A 303 (-3.5A)BEZ A 303 (-4.2A) | 0.00A | 4mf6A-4mf6A:42.3 | 4mf6A-4mf6A:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mx6 | TRAP-TYPEC4-DICARBOXYLATE:H+SYMPORT SYSTEMSUBSTRATE-BINDINGCOMPONENT DCTP (Shewanellaoneidensis) |
PF03480(DctP) | 4 | THR A 49PRO A 50PHE A 202ASN A 156 | NoneNoneSIN A 401 (-2.6A)None | 1.17A | 4mf6A-4mx6A:undetectable | 4mf6A-4mx6A:22.51 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4nax | GLUTATHIONES-TRANSFERASE,N-TERMINAL DOMAINPROTEIN (Pseudomonasputida) |
PF00043(GST_C)PF02798(GST_N) | 5 | THR A 28PRO A 29PHE A 139ASN A 191TYR A 196 | GDS A 301 (-3.5A)GDS A 301 ( 4.5A)NoneNoneNone | 0.30A | 4mf6A-4naxA:36.9 | 4mf6A-4naxA:65.27 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4nhz | PUTATIVE GLUTATHIONES-TRANSFERASE ENZYMEWITHTHIOREDOXIN-LIKEDOMAIN (Bradyrhizobiumsp. BTAi1) |
PF00043(GST_C)PF02798(GST_N) | 5 | THR A 28PRO A 29PHE A 139ASN A 192TYR A 197 | GSH A 301 (-3.5A)GSH A 301 ( 4.9A)NoneNoneNone | 0.55A | 4mf6A-4nhzA:36.6 | 4mf6A-4nhzA:74.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o7m | TRAP DICARBOXYLATETRANSPORTER, DCTPSUBUNIT (Shewanellaloihica) |
PF03480(DctP) | 4 | THR A 46PRO A 47PHE A 199ASN A 153 | NoneNoneLMR A 401 (-3.6A)None | 1.20A | 4mf6A-4o7mA:undetectable | 4mf6A-4o7mA:27.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o94 | TRAP DICARBOXYLATETRANSPORTER DCTPSUBUNIT (Rhodopseudomonaspalustris) |
PF03480(DctP) | 4 | THR A 39PRO A 40PHE A 192ASN A 146 | NoneNoneSIN A 403 (-2.9A)SIN A 403 ( 4.9A) | 1.34A | 4mf6A-4o94A:undetectable | 4mf6A-4o94A:28.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rg8 | EXONUCLEASE I (Methylocaldumszegediense) |
PF00929(RNase_T)PF08411(Exonuc_X-T_C) | 4 | THR A 82PHE A 412ASN A 115TYR A 407 | None | 1.19A | 4mf6A-4rg8A:undetectable | 4mf6A-4rg8A:19.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cm6 | TRAP DICARBOXYLATETRANSPORTER-DCTPSUBUNIT (Pseudoalteromonasatlantica) |
PF03480(DctP) | 4 | THR A 238PHE A 123ASN A 148TYR A 120 | PYR A 401 (-3.8A)NoneNoneNone | 1.44A | 4mf6A-5cm6A:undetectable | 4mf6A-5cm6A:27.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dmd | FLAGELLAR ASSEMBLYFACTOR FLIW (Geobacillusthermodenitrificans) |
PF02623(FliW) | 4 | THR A 42PRO A 43PHE A 138TYR A 65 | None | 1.44A | 4mf6A-5dmdA:undetectable | 4mf6A-5dmdA:19.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fod | LEUCYL-TRNASYNTHETASE (Plasmodiumfalciparum) |
no annotation | 4 | PRO A 448PHE A 683ASN A 449TYR A 451 | None | 1.42A | 4mf6A-5fodA:undetectable | 4mf6A-5fodA:19.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hyp | C4B-BINDING PROTEINALPHA CHAIN (Homo sapiens) |
PF00084(Sushi) | 4 | THR A 7PRO A 6PHE A 59TYR A 56 | None | 1.31A | 4mf6A-5hypA:undetectable | 4mf6A-5hypA:20.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nfh | METHIONYL-TRNASYNTHETASE, PUTATIVE (Trypanosomabrucei) |
no annotation | 4 | THR A 284PHE A 243ASN A 480TYR A 481 | NoneNoneNoneMET A 807 ( 4.9A) | 1.38A | 4mf6A-5nfhA:undetectable | 4mf6A-5nfhA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f74 | ALCOHOL OXIDASE (Thermothelomycesthermophila) |
no annotation | 4 | THR A 27PRO A 28PHE A 587ASN A 149 | NoneNoneGOL A 606 (-4.6A)GOL A 605 (-3.6A) | 1.50A | 4mf6A-6f74A:undetectable | 4mf6A-6f74A:undetectable |