SIMILAR PATTERNS OF AMINO ACIDS FOR 4MF6_A_BEZA303

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b8g PROTEIN
(1-AMINOCYCLOPROPANE
-1-CARBOXYLATE
SYNTHASE)


(Malus domestica)
PF00155
(Aminotran_1_2)
4 THR A 236
PHE A  98
ASN A 330
TYR A 326
None
1.22A 4mf6A-1b8gA:
0.0
4mf6A-1b8gA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bqc PROTEIN
(BETA-MANNANASE)


(Thermobifida
fusca)
PF00150
(Cellulase)
4 THR A 174
PHE A 214
ASN A 173
TYR A 210
None
1.49A 4mf6A-1bqcA:
0.0
4mf6A-1bqcA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1keh PRECURSOR OF
CEPHALOSPORIN
ACYLASE


(Brevundimonas
diminuta)
PF01804
(Penicil_amidase)
4 THR A 625
PRO A 191
PHE A 667
ASN A 190
None
1.46A 4mf6A-1kehA:
undetectable
4mf6A-1kehA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9e HMG-COA SYNTHASE

(Enterococcus
faecalis)
PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C)
4 THR A 152
PHE A 185
ASN A 275
TYR A 277
None
SO4  A 385 ( 3.9A)
SO4  A 385 (-3.2A)
SO4  A 385 (-4.7A)
1.48A 4mf6A-1x9eA:
0.0
4mf6A-1x9eA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zea MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
H CHAIN


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
4 THR H  13
PRO H  14
PHE H 146
ASN H  84
None
1.28A 4mf6A-1zeaH:
undetectable
4mf6A-1zeaH:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bpa PROTEIN (SUBUNIT OF
BACTERIOPHAGE
PHIX174)


(Escherichia
virus phiX174)
PF02305
(Phage_F)
4 THR 1 294
PRO 1 293
PHE 1 334
ASN 1 167
None
1.50A 4mf6A-2bpa1:
0.0
4mf6A-2bpa1:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rii SULFIREDOXIN-1

(Homo sapiens)
PF02195
(ParBc)
4 THR X 133
PRO X 134
PHE X  96
TYR X  94
None
1.40A 4mf6A-2riiX:
undetectable
4mf6A-2riiX:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7x SENSOR PROTEIN

(Bacteroides
thetaiotaomicron)
PF13407
(Peripla_BP_4)
4 THR A 167
PRO A 168
ASN A 136
TYR A 271
None
FRU  A1335 (-4.4A)
None
FRU  A1335 (-4.2A)
1.38A 4mf6A-2x7xA:
undetectable
4mf6A-2x7xA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x98 ALKALINE PHOSPHATASE

(Halobacterium
salinarum)
PF00245
(Alk_phosphatase)
4 THR A 164
PRO A 173
PHE A 210
TYR A 193
None
1.40A 4mf6A-2x98A:
0.0
4mf6A-2x98A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yhe SEC-ALKYL SULFATASE

(Pseudomonas sp.
DSM 6611)
PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C)
4 PRO A 322
PHE A 250
ASN A 318
TYR A 417
None
None
SO4  A 801 (-3.8A)
SO4  A 801 (-4.3A)
1.36A 4mf6A-2yheA:
undetectable
4mf6A-2yheA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f1c PUTATIVE
2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
2


(Listeria
monocytogenes)
PF01128
(IspD)
4 THR A 167
PRO A 168
PHE A 171
ASN A 124
None
1.25A 4mf6A-3f1cA:
undetectable
4mf6A-3f1cA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcy XYLAN ESTERASE 1

(Thermoanaerobacterium
saccharolyticum)
PF05448
(AXE1)
4 THR A 246
PRO A  19
PHE A 231
ASN A  18
None
1.20A 4mf6A-3fcyA:
undetectable
4mf6A-3fcyA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhh OUTER MEMBRANE HEME
RECEPTOR SHUA


(Shigella
dysenteriae)
PF00593
(TonB_dep_Rec)
PF07715
(Plug)
4 THR A 401
PRO A 400
PHE A  16
ASN A 399
None
1.43A 4mf6A-3fhhA:
undetectable
4mf6A-3fhhA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s51 FANCONI ANEMIA GROUP
I PROTEIN HOMOLOG


(Mus musculus)
PF14674
(FANCI_S1-cap)
PF14675
(FANCI_S1)
PF14676
(FANCI_S2)
PF14677
(FANCI_S3)
PF14678
(FANCI_S4)
PF14679
(FANCI_HD1)
PF14680
(FANCI_HD2)
4 THR A1194
PRO A1192
PHE A1177
TYR A1181
None
1.38A 4mf6A-3s51A:
2.9
4mf6A-3s51A:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8u TRANSFERRIN
BINDING-PROTEIN B


(Neisseria
meningitidis)
PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A)
4 THR A 243
PHE A 132
ASN A 124
TYR A 103
None
1.50A 4mf6A-3v8uA:
undetectable
4mf6A-3v8uA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bj1 PROTEIN RIF2

(Saccharomyces
cerevisiae)
no annotation 4 THR A 298
PHE A  74
ASN A 310
TYR A 309
None
1.32A 4mf6A-4bj1A:
undetectable
4mf6A-4bj1A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bj6 RAP1-INTERACTING
FACTOR 2


(Saccharomyces
cerevisiae)
no annotation 4 THR A 298
PHE A  74
ASN A 310
TYR A 309
None
1.20A 4mf6A-4bj6A:
undetectable
4mf6A-4bj6A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cp6 CHOLINE BINDING
PROTEIN PCPA


(Streptococcus
pneumoniae)
PF13306
(LRR_5)
4 THR A 282
PRO A 279
PHE A 290
TYR A 276
None
1.21A 4mf6A-4cp6A:
undetectable
4mf6A-4cp6A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d65 PORIN 2

(Providencia
stuartii)
PF00267
(Porin_1)
4 THR A 132
PHE A  54
ASN A  94
TYR A  78
None
1.50A 4mf6A-4d65A:
undetectable
4mf6A-4d65A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecn LEUCINE-RICH REPEAT
PROTEIN


(Bacteroides
thetaiotaomicron)
PF14660
(DUF4458)
4 THR A 388
PHE A 419
ASN A 485
TYR A 527
None
1.41A 4mf6A-4ecnA:
undetectable
4mf6A-4ecnA:
13.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ikh GLUTATHIONE
S-TRANSFERASE


(Pseudomonas
protegens)
PF00043
(GST_C)
PF02798
(GST_N)
5 THR A  28
PRO A  29
PHE A 139
ASN A 192
TYR A 197
GSH  A 301 (-3.4A)
None
None
None
None
0.34A 4mf6A-4ikhA:
36.3
4mf6A-4ikhA:
68.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jis RIBITOL-5-PHOSPHATE
CYTIDYLYLTRANSFERASE


(Bacillus
subtilis)
PF01128
(IspD)
4 THR A 168
PRO A 169
PHE A 172
ASN A 125
None
1.26A 4mf6A-4jisA:
undetectable
4mf6A-4jisA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9x CELL DEATH PROTEIN 4

(Caenorhabditis
elegans)
PF00619
(CARD)
PF00931
(NB-ARC)
4 THR A 367
PRO A 368
PHE A 301
TYR A 305
ATP  A 602 (-4.4A)
ATP  A 602 (-3.9A)
ATP  A 602 (-4.5A)
None
1.31A 4mf6A-4m9xA:
undetectable
4mf6A-4m9xA:
17.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mf6 GLUTATHIONE
S-TRANSFERASE DOMAIN


(Paraburkholderia
graminis)
PF00043
(GST_C)
PF02798
(GST_N)
5 THR A  28
PRO A  29
PHE A 139
ASN A 192
TYR A 197
GSH  A 301 (-3.3A)
GSH  A 302 ( 4.4A)
BEZ  A 303 (-3.4A)
BEZ  A 303 (-3.5A)
BEZ  A 303 (-4.2A)
0.00A 4mf6A-4mf6A:
42.3
4mf6A-4mf6A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mx6 TRAP-TYPE
C4-DICARBOXYLATE:H+
SYMPORT SYSTEM
SUBSTRATE-BINDING
COMPONENT DCTP


(Shewanella
oneidensis)
PF03480
(DctP)
4 THR A  49
PRO A  50
PHE A 202
ASN A 156
None
None
SIN  A 401 (-2.6A)
None
1.17A 4mf6A-4mx6A:
undetectable
4mf6A-4mx6A:
22.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nax GLUTATHIONE
S-TRANSFERASE,
N-TERMINAL DOMAIN
PROTEIN


(Pseudomonas
putida)
PF00043
(GST_C)
PF02798
(GST_N)
5 THR A  28
PRO A  29
PHE A 139
ASN A 191
TYR A 196
GDS  A 301 (-3.5A)
GDS  A 301 ( 4.5A)
None
None
None
0.30A 4mf6A-4naxA:
36.9
4mf6A-4naxA:
65.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nhz PUTATIVE GLUTATHIONE
S-TRANSFERASE ENZYME
WITH
THIOREDOXIN-LIKE
DOMAIN


(Bradyrhizobium
sp. BTAi1)
PF00043
(GST_C)
PF02798
(GST_N)
5 THR A  28
PRO A  29
PHE A 139
ASN A 192
TYR A 197
GSH  A 301 (-3.5A)
GSH  A 301 ( 4.9A)
None
None
None
0.55A 4mf6A-4nhzA:
36.6
4mf6A-4nhzA:
74.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o7m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT


(Shewanella
loihica)
PF03480
(DctP)
4 THR A  46
PRO A  47
PHE A 199
ASN A 153
None
None
LMR  A 401 (-3.6A)
None
1.20A 4mf6A-4o7mA:
undetectable
4mf6A-4o7mA:
27.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o94 TRAP DICARBOXYLATE
TRANSPORTER DCTP
SUBUNIT


(Rhodopseudomonas
palustris)
PF03480
(DctP)
4 THR A  39
PRO A  40
PHE A 192
ASN A 146
None
None
SIN  A 403 (-2.9A)
SIN  A 403 ( 4.9A)
1.34A 4mf6A-4o94A:
undetectable
4mf6A-4o94A:
28.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rg8 EXONUCLEASE I

(Methylocaldum
szegediense)
PF00929
(RNase_T)
PF08411
(Exonuc_X-T_C)
4 THR A  82
PHE A 412
ASN A 115
TYR A 407
None
1.19A 4mf6A-4rg8A:
undetectable
4mf6A-4rg8A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cm6 TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT


(Pseudoalteromonas
atlantica)
PF03480
(DctP)
4 THR A 238
PHE A 123
ASN A 148
TYR A 120
PYR  A 401 (-3.8A)
None
None
None
1.44A 4mf6A-5cm6A:
undetectable
4mf6A-5cm6A:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmd FLAGELLAR ASSEMBLY
FACTOR FLIW


(Geobacillus
thermodenitrificans)
PF02623
(FliW)
4 THR A  42
PRO A  43
PHE A 138
TYR A  65
None
1.44A 4mf6A-5dmdA:
undetectable
4mf6A-5dmdA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fod LEUCYL-TRNA
SYNTHETASE


(Plasmodium
falciparum)
no annotation 4 PRO A 448
PHE A 683
ASN A 449
TYR A 451
None
1.42A 4mf6A-5fodA:
undetectable
4mf6A-5fodA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hyp C4B-BINDING PROTEIN
ALPHA CHAIN


(Homo sapiens)
PF00084
(Sushi)
4 THR A   7
PRO A   6
PHE A  59
TYR A  56
None
1.31A 4mf6A-5hypA:
undetectable
4mf6A-5hypA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE


(Trypanosoma
brucei)
no annotation 4 THR A 284
PHE A 243
ASN A 480
TYR A 481
None
None
None
MET  A 807 ( 4.9A)
1.38A 4mf6A-5nfhA:
undetectable
4mf6A-5nfhA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f74 ALCOHOL OXIDASE

(Thermothelomyces
thermophila)
no annotation 4 THR A  27
PRO A  28
PHE A 587
ASN A 149
None
None
GOL  A 606 (-4.6A)
GOL  A 605 (-3.6A)
1.50A 4mf6A-6f74A:
undetectable
4mf6A-6f74A:
undetectable