SIMILAR PATTERNS OF AMINO ACIDS FOR 4MBS_B_MRVB1101_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7k 3-METHYLITACONATE
ISOMERASE

(Eubacterium
barkeri) 		PF04303
(PrpF) 		5 PHE A  21
PHE A 295
ILE A  99
TYR A  78
THR A 306
 None
 1.20A 4mbsB-3g7kA:
0.0		 4mbsB-3g7kA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xt1 G-PROTEIN COUPLED
RECEPTOR HOMOLOG
US28

(Cytomegalovirus) 		PF00001
(7tm_1) 		5 TYR A  40
PHE A 116
TRP A 241
TYR A 244
THR A 252
 None
 1.27A 4mbsB-4xt1A:
28.4		 4mbsB-4xt1A:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xt1 G-PROTEIN COUPLED
RECEPTOR HOMOLOG
US28

(Cytomegalovirus) 		PF00001
(7tm_1) 		5 TYR A  40
TRP A  89
TYR A 244
THR A 252
GLU A 277
 None
 1.17A 4mbsB-4xt1A:
28.4		 4mbsB-4xt1A:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b4w PLEXIN-B1

(Homo sapiens) 		PF01403
(Sema)
PF01437
(PSI) 		5 PHE A 218
PHE A 230
ILE A 184
TYR A 261
GLU A 263
 None
 1.23A 4mbsB-5b4wA:
0.0		 4mbsB-5b4wA:
20.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5t1a CHIMERA PROTEIN OF
CC CHEMOKINE
RECEPTOR TYPE 2
ISOFORM B AND
T4-LYSOZYME,LYSOZYME

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 TYR A  49
TRP A  98
PHE A 194
THR A 267
GLU A 291
 73R  A1201 (-4.6A)
73R  A1201 (-3.6A)
None
None
73R  A1201 (-3.4A)
 1.00A 4mbsB-5t1aA:
37.6		 4mbsB-5t1aA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5t1a CHIMERA PROTEIN OF
CC CHEMOKINE
RECEPTOR TYPE 2
ISOFORM B AND
T4-LYSOZYME,LYSOZYME

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		7 TYR A  49
TRP A  98
TYR A 120
TRP A 256
TYR A 259
THR A 267
GLU A 291
 73R  A1201 (-4.6A)
73R  A1201 (-3.6A)
73R  A1201 (-3.8A)
None
None
None
73R  A1201 (-3.4A)
 0.58A 4mbsB-5t1aA:
37.6		 4mbsB-5t1aA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uiw C-C CHEMOKINE
RECEPTOR TYPE
5,RUBREDOXIN CHIMERA

(Clostridium
pasteurianum;
Homo sapiens) 		PF00001
(7tm_1)
PF00301
(Rubredoxin) 		5 PHE A 113
ILE A 198
TRP A 248
TYR A 251
THR A 259
 None
 1.46A 4mbsB-5uiwA:
41.1		 4mbsB-5uiwA:
99.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uiw C-C CHEMOKINE
RECEPTOR TYPE
5,RUBREDOXIN CHIMERA

(Clostridium
pasteurianum;
Homo sapiens) 		PF00001
(7tm_1)
PF00301
(Rubredoxin) 		9 TYR A  37
TRP A  86
PHE A 109
PHE A 112
PHE A 182
ILE A 198
TRP A 248
TYR A 251
THR A 259
 None
 0.78A 4mbsB-5uiwA:
41.1		 4mbsB-5uiwA:
99.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uiw C-C CHEMOKINE
RECEPTOR TYPE
5,RUBREDOXIN CHIMERA

(Clostridium
pasteurianum;
Homo sapiens) 		PF00001
(7tm_1)
PF00301
(Rubredoxin) 		9 TYR A  37
TRP A  86
PHE A 109
PHE A 112
PHE A 182
TRP A 248
TYR A 251
THR A 259
GLU A 283
 None
 0.95A 4mbsB-5uiwA:
41.1		 4mbsB-5uiwA:
99.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uiw C-C CHEMOKINE
RECEPTOR TYPE
5,RUBREDOXIN CHIMERA

(Clostridium
pasteurianum;
Homo sapiens) 		PF00001
(7tm_1)
PF00301
(Rubredoxin) 		9 TYR A  37
TRP A  86
TYR A 108
PHE A 112
PHE A 182
ILE A 198
TRP A 248
TYR A 251
THR A 259
 None
 0.65A 4mbsB-5uiwA:
41.1		 4mbsB-5uiwA:
99.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uiw C-C CHEMOKINE
RECEPTOR TYPE
5,RUBREDOXIN CHIMERA

(Clostridium
pasteurianum;
Homo sapiens) 		PF00001
(7tm_1)
PF00301
(Rubredoxin) 		9 TYR A  37
TRP A  86
TYR A 108
PHE A 112
PHE A 182
TRP A 248
TYR A 251
THR A 259
GLU A 283
 None
 0.87A 4mbsB-5uiwA:
41.1		 4mbsB-5uiwA:
99.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wb1 ENVELOPE PROTEIN
US28, NANOBODY 7
FUSION PROTEIN

(Human
betaherpesvirus
5;
Lama glama) 		no annotation 5 TYR A  40
TRP A  89
TYR A 244
THR A 252
GLU A 277
 None
 1.03A 4mbsB-5wb1A:
28.7		 4mbsB-5wb1A:
10.00