SIMILAR PATTERNS OF AMINO ACIDS FOR 4MBS_A_MRVA1101_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b4w PLEXIN-B1

(Homo sapiens) 		PF01403
(Sema)
PF01437
(PSI) 		5 PHE A 218
PHE A 230
ILE A 184
TYR A 261
GLU A 263
 None
 1.20A 4mbsA-5b4wA:
0.0		 4mbsA-5b4wA:
20.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5t1a CHIMERA PROTEIN OF
CC CHEMOKINE
RECEPTOR TYPE 2
ISOFORM B AND
T4-LYSOZYME,LYSOZYME

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 TYR A  49
TRP A  98
PHE A 194
TYR A 259
GLU A 291
 73R  A1201 (-4.6A)
73R  A1201 (-3.6A)
None
None
73R  A1201 (-3.4A)
 0.98A 4mbsA-5t1aA:
37.0		 4mbsA-5t1aA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5t1a CHIMERA PROTEIN OF
CC CHEMOKINE
RECEPTOR TYPE 2
ISOFORM B AND
T4-LYSOZYME,LYSOZYME

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		6 TYR A  49
TRP A  98
TYR A 120
TRP A 256
TYR A 259
GLU A 291
 73R  A1201 (-4.6A)
73R  A1201 (-3.6A)
73R  A1201 (-3.8A)
None
None
73R  A1201 (-3.4A)
 0.55A 4mbsA-5t1aA:
37.0		 4mbsA-5t1aA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uiw C-C CHEMOKINE
RECEPTOR TYPE
5,RUBREDOXIN CHIMERA

(Clostridium
pasteurianum;
Homo sapiens) 		PF00001
(7tm_1)
PF00301
(Rubredoxin) 		9 TYR A  37
TRP A  86
PHE A 109
PHE A 112
PHE A 182
ILE A 198
TRP A 248
TYR A 251
MET A 279
 None
 0.90A 4mbsA-5uiwA:
39.8		 4mbsA-5uiwA:
99.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uiw C-C CHEMOKINE
RECEPTOR TYPE
5,RUBREDOXIN CHIMERA

(Clostridium
pasteurianum;
Homo sapiens) 		PF00001
(7tm_1)
PF00301
(Rubredoxin) 		9 TYR A  37
TRP A  86
PHE A 109
PHE A 112
PHE A 182
TRP A 248
TYR A 251
MET A 279
GLU A 283
 None
 0.98A 4mbsA-5uiwA:
39.8		 4mbsA-5uiwA:
99.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uiw C-C CHEMOKINE
RECEPTOR TYPE
5,RUBREDOXIN CHIMERA

(Clostridium
pasteurianum;
Homo sapiens) 		PF00001
(7tm_1)
PF00301
(Rubredoxin) 		9 TYR A  37
TRP A  86
TYR A 108
PHE A 112
PHE A 182
ILE A 198
TRP A 248
TYR A 251
MET A 279
 None
 0.81A 4mbsA-5uiwA:
39.8		 4mbsA-5uiwA:
99.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uiw C-C CHEMOKINE
RECEPTOR TYPE
5,RUBREDOXIN CHIMERA

(Clostridium
pasteurianum;
Homo sapiens) 		PF00001
(7tm_1)
PF00301
(Rubredoxin) 		9 TYR A  37
TRP A  86
TYR A 108
PHE A 112
PHE A 182
TRP A 248
TYR A 251
MET A 279
GLU A 283
 None
 0.93A 4mbsA-5uiwA:
39.8		 4mbsA-5uiwA:
99.28