SIMILAR PATTERNS OF AMINO ACIDS FOR 4MBS_A_MRVA1101

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b4w PLEXIN-B1

(Homo sapiens) 		PF01403
(Sema)
PF01437
(PSI) 		5 PHE A 218
PHE A 230
ILE A 184
TYR A 261
GLU A 263
 None
 1.20A 4mbsA-5b4wA:
0.0		 4mbsA-5b4wA:
20.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5t1a CHIMERA PROTEIN OF
CC CHEMOKINE
RECEPTOR TYPE 2
ISOFORM B AND
T4-LYSOZYME,LYSOZYME

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 TYR A  49
TRP A  98
PHE A 194
TYR A 259
GLU A 291
 73R  A1201 (-4.6A)
73R  A1201 (-3.6A)
None
None
73R  A1201 (-3.4A)
 0.98A 4mbsA-5t1aA:
37.0		 4mbsA-5t1aA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5t1a CHIMERA PROTEIN OF
CC CHEMOKINE
RECEPTOR TYPE 2
ISOFORM B AND
T4-LYSOZYME,LYSOZYME

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		6 TYR A  49
TRP A  98
TYR A 120
TRP A 256
TYR A 259
GLU A 291
 73R  A1201 (-4.6A)
73R  A1201 (-3.6A)
73R  A1201 (-3.8A)
None
None
73R  A1201 (-3.4A)
 0.55A 4mbsA-5t1aA:
37.0		 4mbsA-5t1aA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uiw C-C CHEMOKINE
RECEPTOR TYPE
5,RUBREDOXIN CHIMERA

(Clostridium
pasteurianum;
Homo sapiens) 		PF00001
(7tm_1)
PF00301
(Rubredoxin) 		9 TYR A  37
TRP A  86
PHE A 109
PHE A 112
PHE A 182
ILE A 198
TRP A 248
TYR A 251
MET A 279
 None
 0.90A 4mbsA-5uiwA:
39.8		 4mbsA-5uiwA:
99.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uiw C-C CHEMOKINE
RECEPTOR TYPE
5,RUBREDOXIN CHIMERA

(Clostridium
pasteurianum;
Homo sapiens) 		PF00001
(7tm_1)
PF00301
(Rubredoxin) 		9 TYR A  37
TRP A  86
PHE A 109
PHE A 112
PHE A 182
TRP A 248
TYR A 251
MET A 279
GLU A 283
 None
 0.98A 4mbsA-5uiwA:
39.8		 4mbsA-5uiwA:
99.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uiw C-C CHEMOKINE
RECEPTOR TYPE
5,RUBREDOXIN CHIMERA

(Clostridium
pasteurianum;
Homo sapiens) 		PF00001
(7tm_1)
PF00301
(Rubredoxin) 		9 TYR A  37
TRP A  86
TYR A 108
PHE A 112
PHE A 182
ILE A 198
TRP A 248
TYR A 251
MET A 279
 None
 0.81A 4mbsA-5uiwA:
39.8		 4mbsA-5uiwA:
99.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uiw C-C CHEMOKINE
RECEPTOR TYPE
5,RUBREDOXIN CHIMERA

(Clostridium
pasteurianum;
Homo sapiens) 		PF00001
(7tm_1)
PF00301
(Rubredoxin) 		9 TYR A  37
TRP A  86
TYR A 108
PHE A 112
PHE A 182
TRP A 248
TYR A 251
MET A 279
GLU A 283
 None
 0.93A 4mbsA-5uiwA:
39.8		 4mbsA-5uiwA:
99.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e51 DELTA-AMINOLEVULINIC
ACID DEHYDRATASE

(Homo sapiens) 		PF00490
(ALAD) 		4 GLN A 322
THR A 320
LEU A  31
THR A  24
 None
 1.14A 4mbsA-1e51A:
undetectable		 4mbsA-1e51A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzg DELTA-AMINOLEVULINIC
ACID DEHYDRATASE

(Pseudomonas
aeruginosa) 		PF00490
(ALAD) 		4 GLN A 160
THR A 126
THR A 112
THR A 195
 None
 1.08A 4mbsA-1gzgA:
0.0		 4mbsA-1gzgA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hlm HEMOGLOBIN (CYANO
MET)

(Molpadia
arenicola) 		PF00042
(Globin) 		4 GLN A 149
LEU A  97
THR A 101
THR A  82
 None
 1.13A 4mbsA-1hlmA:
0.0		 4mbsA-1hlmA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0n XANTHAN LYASE

(Bacillus sp.
GL1) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 TYR A 390
THR A 248
THR A 476
MET A 303
 None
 1.14A 4mbsA-1j0nA:
0.0		 4mbsA-1j0nA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jal YCHF PROTEIN

(Haemophilus
influenzae) 		PF01926
(MMR_HSR1)
PF06071
(YchF-GTPase_C) 		4 GLN A 280
THR A 294
THR A  66
THR A  97
 None
 1.07A 4mbsA-1jalA:
0.0		 4mbsA-1jalA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9o ALASERPIN

(Manduca sexta) 		PF00079
(Serpin) 		4 GLN I  56
LEU I  73
THR I  81
THR I  27
 None
 1.11A 4mbsA-1k9oI:
0.0		 4mbsA-1k9oI:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lf9 GLUCOAMYLASE

(Thermoanaerobacterium
thermosaccharolyticum) 		PF00723
(Glyco_hydro_15)
PF09137
(Glucodextran_N) 		4 GLN A 434
THR A 432
THR A 447
MET A 516
 ACR  A 700 ( 3.9A)
None
None
None
 1.13A 4mbsA-1lf9A:
undetectable		 4mbsA-1lf9A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ms8 TRANS-SIALIDASE

(Trypanosoma
cruzi) 		PF13385
(Laminin_G_3)
PF13859
(BNR_3) 		4 GLN A 325
THR A 269
LEU A 270
THR A 303
 None
 1.07A 4mbsA-1ms8A:
0.0		 4mbsA-1ms8A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mz5 SIALIDASE

(Trypanosoma
rangeli) 		PF13385
(Laminin_G_3)
PF13859
(BNR_3) 		4 GLN A 326
THR A 270
LEU A 271
THR A 304
 None
 1.09A 4mbsA-1mz5A:
0.0		 4mbsA-1mz5A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nt4 GLUCOSE-1-PHOSPHATAS
E

(Escherichia
coli) 		PF00328
(His_Phos_2) 		4 TYR A 247
LEU A  20
THR A  50
THR A 314
 None
 1.01A 4mbsA-1nt4A:
undetectable		 4mbsA-1nt4A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pn3 GLYCOSYLTRANSFERASE
GTFA

(Amycolatopsis
orientalis) 		PF03033
(Glyco_transf_28) 		4 TYR A 121
LEU A 185
THR A 299
THR A 198
 None
 0.92A 4mbsA-1pn3A:
undetectable		 4mbsA-1pn3A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pto PERTUSSIS TOXIN

(Bordetella
pertussis) 		PF02918
(Pertussis_S2S3)
PF03440
(APT) 		4 GLN C  16
THR C  14
THR C  27
THR C  61
 None
 0.87A 4mbsA-1ptoC:
undetectable		 4mbsA-1ptoC:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qon ACETYLCHOLINESTERASE

(Drosophila
melanogaster) 		PF00135
(COesterase) 		4 TYR A  71
GLN A 263
THR A 444
MET A 476
 I40  A 997 ( 3.8A)
None
None
None
 0.95A 4mbsA-1qonA:
undetectable		 4mbsA-1qonA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6z CHIMERA OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND ARGONAUTE 2

(Drosophila
melanogaster;
Escherichia
coli) 		no annotation 4 GLN P 252
THR P 127
THR P 319
MET P 320
 None
 1.10A 4mbsA-1r6zP:
undetectable		 4mbsA-1r6zP:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r9l GLYCINE
BETAINE-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF04069
(OpuAC) 		4 GLN A  94
THR A 187
LEU A  97
THR A 109
 None
 1.01A 4mbsA-1r9lA:
undetectable		 4mbsA-1r9lA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w3f HEMOLYTIC LECTIN
FROM LAETIPORUS
SULPHUREUS

(Laetiporus
sulphureus) 		PF03318
(ETX_MTX2) 		4 TYR A 104
GLN A 135
THR A 118
THR A 145
 None
 1.08A 4mbsA-1w3fA:
undetectable		 4mbsA-1w3fA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wiw GLUCOSE-6-PHOSPHATE
ISOMERASE LIKE
PROTEIN

(Thermus
thermophilus) 		PF10432
(bact-PGI_C) 		4 LEU A  17
THR A  15
THR A 265
MET A 262
 None
 1.14A 4mbsA-1wiwA:
undetectable		 4mbsA-1wiwA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2adb POLYPYRIMIDINE
TRACT-BINDING
PROTEIN 1

(Homo sapiens) 		PF00076
(RRM_1) 		4 GLN A 223
LEU A 200
THR A 196
THR A 209
 C  B 301 ( 2.7A)
None
None
None
 1.01A 4mbsA-2adbA:
undetectable		 4mbsA-2adbA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b39 C3

(Bos taurus) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		4 GLN A  54
THR A  74
LEU A  44
THR A 646
 None
 1.02A 4mbsA-2b39A:
undetectable		 4mbsA-2b39A:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1

(Homo sapiens) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		4 GLN A 740
THR A 741
LEU A 669
THR A 677
 None
 0.85A 4mbsA-2b3xA:
undetectable		 4mbsA-2b3xA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c91 AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 2

(Mus musculus) 		PF00248
(Aldo_ket_red) 		4 TYR A 205
THR A 298
THR A   8
THR A 171
 None
 1.14A 4mbsA-2c91A:
undetectable		 4mbsA-2c91A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cde INKT-TCR

(Homo sapiens) 		PF07686
(V-set)
PF09291
(DUF1968) 		4 GLN A 109
THR A 108
LEU A  21
THR A  78
 None
 0.98A 4mbsA-2cdeA:
undetectable		 4mbsA-2cdeA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fja ADENYLYLSULFATE
REDUCTASE, SUBUNIT A

(Archaeoglobus
fulgidus) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 TYR A 489
THR A  53
LEU A  26
THR A  23
 None
 1.11A 4mbsA-2fjaA:
undetectable		 4mbsA-2fjaA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2huj LIN2004 PROTEIN

(Listeria
innocua) 		PF08807
(DUF1798) 		4 GLN A  74
LEU A  67
THR A 106
THR A  61
 None
 1.12A 4mbsA-2hujA:
3.2		 4mbsA-2hujA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ox4 PUTATIVE MANDELATE
RACEMASE

(Zymomonas
mobilis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 TYR A  42
GLN A 375
LEU A 381
THR A  13
 None
 0.98A 4mbsA-2ox4A:
undetectable		 4mbsA-2ox4A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p7n PATHOGENICITY ISLAND
1 EFFECTOR PROTEIN

(Chromobacterium
violaceum) 		PF06511
(IpaD) 		4 GLN A  73
THR A  74
LEU A 361
THR A 365
 None
 1.12A 4mbsA-2p7nA:
3.6		 4mbsA-2p7nA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal disease
virus) 		PF04197
(Birna_RdRp) 		4 THR A 498
LEU A 205
THR A 209
THR A 722
 None
 0.89A 4mbsA-2pggA:
undetectable		 4mbsA-2pggA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q7n LEUKEMIA INHIBITORY
FACTOR RECEPTOR

(Mus musculus) 		PF00041
(fn3) 		4 GLN A 247
THR A 227
THR A 270
THR A 202
 None
 1.08A 4mbsA-2q7nA:
undetectable		 4mbsA-2q7nA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr4 PEPTIDASE M3B,
OLIGOENDOPEPTIDASE F

(Enterococcus
faecium) 		PF01432
(Peptidase_M3)
PF08439
(Peptidase_M3_N) 		4 TYR A 555
GLN A 461
THR A 462
LEU A 274
 None
 1.01A 4mbsA-2qr4A:
undetectable		 4mbsA-2qr4A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE

(Escherichia
coli) 		PF01276
(OKR_DC_1)
PF03709
(OKR_DC_1_N)
PF03711
(OKR_DC_1_C) 		4 GLN A 577
THR A 573
THR A 560
THR A 552
 None
 1.00A 4mbsA-2vycA:
undetectable		 4mbsA-2vycA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3p BENZOYL-COA-DIHYDROD
IOL LYASE

(Paraburkholderia
xenovorans) 		PF00378
(ECH_1) 		4 GLN A 524
THR A 178
THR A 114
THR A 511
 BME  A 601 (-4.4A)
BME  A 601 (-4.1A)
None
None
 1.07A 4mbsA-2w3pA:
undetectable		 4mbsA-2w3pA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wmh FUCOLECTIN-RELATED
PROTEIN

(Streptococcus
pneumoniae) 		PF08306
(Glyco_hydro_98M)
PF08307
(Glyco_hydro_98C) 		4 TYR A 440
THR A 252
THR A 306
THR A 474
 None
 1.02A 4mbsA-2wmhA:
undetectable		 4mbsA-2wmhA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wmh FUCOLECTIN-RELATED
PROTEIN

(Streptococcus
pneumoniae) 		PF08306
(Glyco_hydro_98M)
PF08307
(Glyco_hydro_98C) 		4 TYR A 459
THR A 539
LEU A 489
THR A 474
 None
 0.80A 4mbsA-2wmhA:
undetectable		 4mbsA-2wmhA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2k TRNA(ILE)-LYSIDINE
SYNTHASE

(Geobacillus
kaustophilus) 		PF01171
(ATP_bind_3)
PF09179
(TilS)
PF11734
(TilS_C) 		4 GLN A 212
LEU A 217
THR A 135
MET A 138
 None
None
A  C  36 ( 4.8A)
C  C  35 ( 3.4A)
 0.89A 4mbsA-3a2kA:
undetectable		 4mbsA-3a2kA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b5q PUTATIVE SULFATASE
YIDJ

(Bacteroides
thetaiotaomicron) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		4 GLN A  36
THR A  37
THR A 295
MET A 293
 EDO  A 514 (-4.2A)
EDO  A 508 (-3.1A)
None
None
 1.08A 4mbsA-3b5qA:
undetectable		 4mbsA-3b5qA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bb5 STRESS RESPONSIVE
ALPHA-BETA PROTEIN

(Jannaschia sp.
CCS1) 		PF07876
(Dabb) 		4 GLN A  78
THR A  76
LEU A  29
THR A  37
 None
 1.04A 4mbsA-3bb5A:
undetectable		 4mbsA-3bb5A:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bb5 STRESS RESPONSIVE
ALPHA-BETA PROTEIN

(Jannaschia sp.
CCS1) 		PF07876
(Dabb) 		4 GLN A  78
THR A  76
LEU A  29
THR A  61
 None
 1.02A 4mbsA-3bb5A:
undetectable		 4mbsA-3bb5A:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c9h ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN

(Agrobacterium
fabrum) 		PF13416
(SBP_bac_8) 		4 TYR A 280
GLN A  20
LEU A  69
THR A 215
 None
None
CIT  A 402 (-3.9A)
CIT  A 402 (-4.0A)
 1.12A 4mbsA-3c9hA:
undetectable		 4mbsA-3c9hA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4i GLYCOSYLTRANSFERASE
GTFA,
GLYCOSYLTRANSFERASE

(Actinoplanes
teichomyceticus;
Amycolatopsis
orientalis) 		PF03033
(Glyco_transf_28)
PF04101
(Glyco_tran_28_C) 		4 TYR A 121
LEU A 185
THR A 297
THR A 198
 None
 1.05A 4mbsA-3h4iA:
undetectable		 4mbsA-3h4iA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h74 PYRIDOXAL KINASE

(Lactobacillus
plantarum) 		PF08543
(Phos_pyr_kin) 		4 TYR A  93
LEU A  22
THR A  26
THR A  37
 None
 1.02A 4mbsA-3h74A:
undetectable		 4mbsA-3h74A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbu SECRETED PROTEASE C

(Dickeya
chrysanthemi) 		PF00353
(HemolysinCabind)
PF00413
(Peptidase_M10)
PF08548
(Peptidase_M10_C) 		4 TYR P 238
GLN P  56
THR P  58
THR P 187
 None
 1.10A 4mbsA-3hbuP:
undetectable		 4mbsA-3hbuP:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ho8 PYRUVATE CARBOXYLASE

(Staphylococcus
aureus) 		PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 GLN A 785
THR A 782
LEU A 747
THR A 719
 None
 1.15A 4mbsA-3ho8A:
undetectable		 4mbsA-3ho8A:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6d PROTOPORPHYRINOGEN
OXIDASE

(Bacillus
subtilis) 		PF01593
(Amino_oxidase) 		4 GLN A 228
THR A 229
LEU A 234
THR A  16
 None
None
None
FAD  A 600 (-3.4A)
 0.80A 4mbsA-3i6dA:
undetectable		 4mbsA-3i6dA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbe NANOBODY VHH PVSS8A

(Camelus
dromedarius) 		PF07686
(V-set) 		4 GLN 7 121
THR 7 120
LEU 7  20
THR 7  69
 None
 1.03A 4mbsA-3jbe7:
undetectable		 4mbsA-3jbe7:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4e UNCHARACTERIZED
PEPTIDASE LMO0363

(Listeria
monocytogenes) 		PF03575
(Peptidase_S51) 		4 TYR A  83
THR A 170
LEU A 158
THR A 125
 None
 1.13A 4mbsA-3l4eA:
undetectable		 4mbsA-3l4eA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ld8 BIFUNCTIONAL
ARGININE DEMETHYLASE
AND
LYSYL-HYDROXYLASE
JMJD6

(Homo sapiens) 		PF02373
(JmjC) 		4 TYR A 117
GLN A 286
THR A 264
THR A  86
 None
 1.07A 4mbsA-3ld8A:
undetectable		 4mbsA-3ld8A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mxl NITROSOSYNTHASE

(Micromonospora
sp. ATCC 39149) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 GLN A 330
THR A 246
THR A  75
MET A  78
 None
 1.10A 4mbsA-3mxlA:
1.7		 4mbsA-3mxlA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntl ACID
GLUCOSE-1-PHOSPHATE
PHOSPHATASE

(Enterobacter
cloacae) 		PF00328
(His_Phos_2) 		4 TYR A 245
LEU A  18
THR A  48
THR A 312
 IHP  A 550 (-4.8A)
None
None
None
 0.97A 4mbsA-3ntlA:
undetectable		 4mbsA-3ntlA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pf0 IMELYSIN-LIKE
PROTEIN

(Psychrobacter
arcticus) 		PF09375
(Peptidase_M75) 		4 GLN A 356
THR A 354
LEU A 339
THR A 331
 None
 1.11A 4mbsA-3pf0A:
1.5		 4mbsA-3pf0A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ruc WBGU

(Plesiomonas
shigelloides) 		PF01370
(Epimerase) 		4 TYR A 193
GLN A  41
THR A  18
THR A 188
 NAD  A 343 ( 4.6A)
None
None
None
 1.05A 4mbsA-3rucA:
undetectable		 4mbsA-3rucA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3teu FIBCON

(-) 		PF00041
(fn3) 		4 TYR A  73
GLN A  88
THR A  90
LEU A  62
 None
 1.12A 4mbsA-3teuA:
undetectable		 4mbsA-3teuA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ww0 PROTEIN HIKESHI

(Homo sapiens) 		PF05603
(DUF775) 		4 GLN B  12
THR B  13
LEU B  41
THR B  74
 None
 1.07A 4mbsA-3ww0B:
undetectable		 4mbsA-3ww0B:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3v E1 ENVELOPE
GLYCOPROTEIN

(Rubella virus) 		PF05748
(Rubella_E1) 		4 THR A   5
LEU A 324
THR A  15
THR A 179
 None
 1.13A 4mbsA-4b3vA:
undetectable		 4mbsA-4b3vA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3v E1 ENVELOPE
GLYCOPROTEIN

(Rubella virus) 		PF05748
(Rubella_E1) 		4 THR A  15
LEU A   7
THR A   5
THR A 179
 None
 1.15A 4mbsA-4b3vA:
undetectable		 4mbsA-4b3vA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d65 PORIN 2

(Providencia
stuartii) 		PF00267
(Porin_1) 		4 TYR A  95
LEU A 262
THR A 270
MET A 232
 None
 1.09A 4mbsA-4d65A:
undetectable		 4mbsA-4d65A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e6w CLBP PEPTIDASE

(Escherichia
coli) 		PF00144
(Beta-lactamase) 		4 GLN A 170
THR A 154
LEU A 150
THR A 139
 None
 1.07A 4mbsA-4e6wA:
undetectable		 4mbsA-4e6wA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ew6 D-GALACTOSE-1-DEHYDR
OGENASE PROTEIN

(Rhizobium etli) 		PF01408
(GFO_IDH_MocA) 		4 GLN A 240
THR A 236
THR A 135
THR A 178
 None
 1.12A 4mbsA-4ew6A:
undetectable		 4mbsA-4ew6A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4faj PRGZ

(Enterococcus
faecalis) 		PF00496
(SBP_bac_5) 		4 TYR A 311
GLN A  81
THR A  82
THR A  68
 None
 0.84A 4mbsA-4fajA:
undetectable		 4mbsA-4fajA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gqa NAD BINDING
OXIDOREDUCTASE

(Klebsiella
pneumoniae) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 TYR A  30
GLN A  17
LEU A   9
THR A  81
 None
 1.04A 4mbsA-4gqaA:
undetectable		 4mbsA-4gqaA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h8q IRON
TRANSPORT-ASSOCIATED
DOMAIN PROTEIN

(Bacillus
anthracis) 		PF05031
(NEAT) 		4 GLN A  60
THR A  61
THR A  29
MET A  26
 None
None
None
HEM  A 201 (-2.9A)
 1.10A 4mbsA-4h8qA:
undetectable		 4mbsA-4h8qA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iyq DIVALENT ION
TOLERANCE PROTEIN
CUTA1

(Ehrlichia
chaffeensis) 		PF03091
(CutA1) 		4 GLN A  68
LEU A   8
THR A  62
THR A  12
 None
 1.13A 4mbsA-4iyqA:
undetectable		 4mbsA-4iyqA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrl PUTATIVE GLYCOSIDE
HYDROLASE

(Bacteroides
ovatus) 		PF13201
(PCMD) 		4 GLN A  64
THR A  89
THR A  86
THR A 102
 None
 1.13A 4mbsA-4jrlA:
undetectable		 4mbsA-4jrlA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc5 RHIE PROTEIN

(Paraburkholderia
rhizoxinica) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 GLN A3545
THR A3543
LEU A3635
THR A3524
 None
 0.89A 4mbsA-4kc5A:
undetectable		 4mbsA-4kc5A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kca ENDO-1,5-ALPHA-L-ARA
BINANASE

(Bos taurus) 		PF00085
(Thioredoxin)
PF04616
(Glyco_hydro_43)
PF16369
(GH43_C) 		4 LEU A 247
THR A 249
THR A 322
MET A 332
 None
IOD  A 730 (-4.3A)
None
None
 0.94A 4mbsA-4kcaA:
undetectable		 4mbsA-4kcaA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m01 SERINE-RICH ADHESIN
FOR PLATELETS

(Staphylococcus
aureus) 		no annotation 4 GLN A 289
THR A 288
THR A 475
THR A 424
 None
 1.06A 4mbsA-4m01A:
undetectable		 4mbsA-4m01A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4my5 PUTATIVE AMINO ACID
AMINOTRANSFERASE

(Streptococcus
mutans) 		PF00155
(Aminotran_1_2) 		4 GLN A 258
THR A 256
LEU A  95
THR A 268
 None
 1.07A 4mbsA-4my5A:
undetectable		 4mbsA-4my5A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p29 LPOA

(Haemophilus
influenzae) 		PF04348
(LppC) 		4 GLN A  63
THR A  64
LEU A  38
THR A  35
 None
 0.98A 4mbsA-4p29A:
undetectable		 4mbsA-4p29A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxd ALLANTOATE
AMIDOHYDROLASE

(Escherichia
coli) 		PF01546
(Peptidase_M20) 		4 GLN A   7
LEU A 102
THR A  12
THR A 399
 None
 1.14A 4mbsA-4pxdA:
undetectable		 4mbsA-4pxdA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbk DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Lactobacillus
brevis) 		PF01791
(DeoC) 		4 GLN A   7
THR A   5
LEU A 218
THR A  15
 None
 1.02A 4mbsA-4xbkA:
undetectable		 4mbsA-4xbkA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoq INTRACELLULAR SERINE
PROTEASE

(Bacillus
licheniformis) 		PF00082
(Peptidase_S8) 		4 GLN I 129
LEU I 388
THR I 135
THR I 202
 None
 1.12A 4mbsA-4zoqI:
undetectable		 4mbsA-4zoqI:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah1 TRIACYLGLYCEROL
LIPASE

(Clostridium
botulinum) 		no annotation 4 TYR A 138
GLN A 284
LEU A 253
THR A 257
 None
 1.05A 4mbsA-5ah1A:
undetectable		 4mbsA-5ah1A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c41 RIBOKINASE

(Homo sapiens) 		PF00294
(PfkB) 		4 TYR A  99
THR A 174
LEU A 164
THR A 156
 None
 0.95A 4mbsA-5c41A:
undetectable		 4mbsA-5c41A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c7r FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND TYPE-3
ICE-STRUCTURING
PROTEIN HPLC 12

(Escherichia
coli;
Zoarces
americanus) 		PF01547
(SBP_bac_1) 		4 GLN A 253
THR A 128
THR A 320
MET A 321
 None
 1.10A 4mbsA-5c7rA:
undetectable		 4mbsA-5c7rA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csl ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
PF08326
(ACC_central) 		4 GLN A 405
LEU A 304
THR A 390
MET A 393
 None
 0.96A 4mbsA-5cslA:
undetectable		 4mbsA-5cslA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6k POLYKETIDE SYNTHASE
PKSL

(Bacillus
subtilis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 GLN A 479
THR A 477
LEU A 578
THR A 464
 None
 1.11A 4mbsA-5e6kA:
undetectable		 4mbsA-5e6kA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eny POLYKETIDE SYNTHASE
PKSL

(Bacillus
subtilis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 GLN A 479
THR A 477
LEU A 578
THR A 464
 None
 1.04A 4mbsA-5enyA:
undetectable		 4mbsA-5enyA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7s GLYCOSIDE HYDROLASE
FAMILY 31

(Trueperella
pyogenes) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 GLN A 639
THR A 640
LEU A 556
THR A 549
 None
 0.84A 4mbsA-5f7sA:
undetectable		 4mbsA-5f7sA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 TYR B  42
GLN B  99
THR B  97
THR B 646
 None
 1.10A 4mbsA-5fq6B:
undetectable		 4mbsA-5fq6B:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gp4 GLUTAMATE
DECARBOXYLASE

(Lactobacillus
brevis) 		no annotation 4 TYR C 253
THR C 361
LEU C 368
THR C 217
 None
 1.10A 4mbsA-5gp4C:
undetectable		 4mbsA-5gp4C:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hw3 BETA-LACTAMASE

(Burkholderia
vietnamiensis) 		PF13354
(Beta-lactamase2) 		4 TYR A 245
THR A 134
THR A 109
THR A 236
 None
None
None
SO4  A 301 (-3.5A)
 1.10A 4mbsA-5hw3A:
undetectable		 4mbsA-5hw3A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5u RAGB/SUSD DOMAIN
PROTEIN

(Flavobacterium
johnsoniae) 		PF12771
(SusD-like_2) 		4 GLN A 362
LEU A 428
THR A 431
THR A 419
 None
 1.06A 4mbsA-5j5uA:
undetectable		 4mbsA-5j5uA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l35 GENE 5 PROTEIN

(Shigella virus
Sf6) 		PF11651
(P22_CoatProtein) 		4 TYR A 285
GLN A 332
THR A 321
THR A 280
 None
 0.99A 4mbsA-5l35A:
undetectable		 4mbsA-5l35A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oki DNA POLYMERASE
EPSILON CATALYTIC
SUBUNIT A

(Saccharomyces
cerevisiae) 		no annotation 4 GLN A 468
LEU A 321
THR A 323
THR A 481
 None
 1.14A 4mbsA-5okiA:
undetectable		 4mbsA-5okiA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opt 40S RIBOSOMAL
PROTEIN S3A-2

(Trypanosoma
cruzi) 		no annotation 4 GLN W 101
LEU W 137
THR W 131
MET W 107
 None
 1.14A 4mbsA-5optW:
undetectable		 4mbsA-5optW:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tuf TETRACYCLINE
DESTRUCTASE TET(50)

(uncultured
bacterium) 		PF01494
(FAD_binding_3) 		4 LEU A 174
THR A 272
THR A 162
MET A 165
 None
 1.08A 4mbsA-5tufA:
undetectable		 4mbsA-5tufA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tuk TETRACYCLINE
DESTRUCTASE TET(51)

(uncultured
bacterium) 		PF01494
(FAD_binding_3) 		4 LEU A 174
THR A 272
THR A 162
MET A 165
 None
 1.07A 4mbsA-5tukA:
undetectable		 4mbsA-5tukA:
23.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uiw C-C CHEMOKINE
RECEPTOR TYPE
5,RUBREDOXIN CHIMERA

(Clostridium
pasteurianum;
Homo sapiens) 		PF00001
(7tm_1)
PF00301
(Rubredoxin) 		6 TYR A  89
GLN A 194
THR A 195
LEU A 255
THR A 259
THR A 284
 None
None
PCA  B   0 ( 4.3A)
None
None
OLC  A1107 ( 4.3A)
 0.63A 4mbsA-5uiwA:
39.8		 4mbsA-5uiwA:
99.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uiw C-C CHEMOKINE
RECEPTOR TYPE
5,RUBREDOXIN CHIMERA

(Clostridium
pasteurianum;
Homo sapiens) 		PF00001
(7tm_1)
PF00301
(Rubredoxin) 		5 TYR A  89
THR A 195
THR A 259
THR A 284
MET A 287
 None
PCA  B   0 ( 4.3A)
None
OLC  A1107 ( 4.3A)
None
 0.99A 4mbsA-5uiwA:
39.8		 4mbsA-5uiwA:
99.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8f DNA REPLICATION
LICENSING FACTOR
MCM7

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		4 TYR 7 574
GLN 7 683
THR 7 685
THR 7 688
 None
 1.05A 4mbsA-5v8f7:
undetectable		 4mbsA-5v8f7:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vat PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOA

(Haemophilus
influenzae) 		PF04348
(LppC) 		4 GLN A  63
THR A  64
LEU A  38
THR A  35
 None
 0.99A 4mbsA-5vatA:
undetectable		 4mbsA-5vatA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7d ACYLOXYACYL
HYDROLASE

(Mus musculus) 		no annotation 4 GLN A 390
LEU A 479
THR A 482
THR A 470
 None
 0.87A 4mbsA-5w7dA:
undetectable		 4mbsA-5w7dA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wsl KERATINASE

(Meiothermus
taiwanensis) 		no annotation 4 GLN A  15
LEU A 273
THR A 258
THR A 227
 CA  A 301 ( 3.3A)
None
None
None
 0.99A 4mbsA-5wslA:
undetectable		 4mbsA-5wslA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xb7 BETA-GALACTOSIDASE

(Bifidobacterium
animalis) 		no annotation 4 TYR A 429
GLN A 589
THR A 579
LEU A 555
 None
 0.91A 4mbsA-5xb7A:
undetectable		 4mbsA-5xb7A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xm3 GLUCOSE
DEHYDROGENASE

(Methylophaga
aminisulfidivorans) 		no annotation 4 GLN A 202
THR A 216
THR A 308
MET A 309
 None
 0.98A 4mbsA-5xm3A:
undetectable		 4mbsA-5xm3A:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zq6 SIDE

(Legionella
pneumophila) 		no annotation 4 GLN A 575
THR A 576
THR A 440
THR A 794
 None
 1.07A 4mbsA-5zq6A:
2.6		 4mbsA-5zq6A:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6egt GLYCOPROTEIN

(Rift Valley
fever
phlebovirus) 		no annotation 4 GLN A 741
THR A 742
THR A 718
MET A1014
 None
 1.01A 4mbsA-6egtA:
undetectable		 4mbsA-6egtA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5o RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza B
virus) 		no annotation 4 TYR B  56
THR B  39
LEU B 351
THR B 226
 None
 1.07A 4mbsA-6f5oB:
undetectable		 4mbsA-6f5oB:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fik POLYKETIDE SYNTHASE

(Cercospora
nicotianae) 		no annotation 4 GLN A 891
THR A 885
THR A1230
THR A 847
 None
 1.04A 4mbsA-6fikA:
undetectable		 4mbsA-6fikA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fqc BIFUNCTIONAL
ARGININE DEMETHYLASE
AND
LYSYL-HYDROXYLASE
JMJD6

(Homo sapiens) 		no annotation 4 TYR A 117
GLN A 286
THR A 264
THR A  86
 None
 1.05A 4mbsA-6fqcA:
undetectable		 4mbsA-6fqcA:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4

(Mus musculus) 		no annotation 4 LEU M  65
THR M  69
THR M 455
MET M 310
 None
 1.14A 4mbsA-6g2jM:
undetectable		 4mbsA-6g2jM:
9.74