SIMILAR PATTERNS OF AMINO ACIDS FOR 4MA8_C_Z80C301_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezw COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE

(Methanopyrus
kandleri) 		PF00296
(Bac_luciferase) 		4 GLY A 284
ILE A 274
LYS A 270
GLN A 273
 None
 1.18A 4ma8C-1ezwA:
0.0		 4ma8C-1ezwA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz7 LIPASE 2

(Diutina rugosa) 		PF00135
(COesterase) 		4 LEU A 127
GLY A 128
ILE A  86
GLN A  88
 None
 1.17A 4ma8C-1gz7A:
1.0		 4ma8C-1gz7A:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyq CELL DIVISION
INHIBITOR (MIND-1)

(Archaeoglobus
fulgidus) 		PF01656
(CbiA) 		4 LEU A  27
GLY A  24
ILE A   5
LYS A   2
 None
 0.99A 4ma8C-1hyqA:
0.0		 4ma8C-1hyqA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1knl ENDO-1,4-BETA-XYLANA
SE A

(Streptomyces
lividans) 		PF00652
(Ricin_B_lectin) 		4 GLY A 106
ILE A 113
LYS A  69
GLN A 114
 None
 0.77A 4ma8C-1knlA:
undetectable		 4ma8C-1knlA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l4a S-SNAP25 FUSION
PROTEIN
SYNAPTOBREVIN

(Doryteuthis
pealeii) 		PF00957
(Synaptobrevin)
no annotation 		4 LEU C  60
GLY C  57
ILE A  69
LYS A  68
 LEU  C  60 ( 0.6A)
GLY  C  57 ( 0.0A)
ILE  A  69 ( 0.7A)
LYS  A  68 ( 0.0A)
 1.11A 4ma8C-1l4aC:
undetectable		 4ma8C-1l4aC:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m54 CYSTATHIONINE
BETA-SYNTHASE

(Homo sapiens) 		PF00291
(PALP) 		4 LEU A 154
GLY A 153
ILE A 122
GLN A 222
 None
 1.20A 4ma8C-1m54A:
0.0		 4ma8C-1m54A:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mir PROCATHEPSIN B

(Rattus
norvegicus) 		PF00112
(Peptidase_C1)
PF08127
(Propeptide_C1) 		4 GLY A 193
ILE A  17
LYS A  19
GLN A  20
 None
 1.05A 4ma8C-1mirA:
0.0		 4ma8C-1mirA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mn6 POLYKETIDE SYNTHASE
IV

(Streptomyces
venezuelae) 		PF00975
(Thioesterase) 		4 LEU A 152
GLY A 149
ILE A 186
GLN A 183
 None
 1.17A 4ma8C-1mn6A:
0.0		 4ma8C-1mn6A:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n0e PROTEIN MRAZ

(Mycoplasma
pneumoniae) 		PF02381
(MraZ) 		4 LEU A  43
GLY A 110
ILE A  55
LYS A  69
 None
 1.17A 4ma8C-1n0eA:
0.0		 4ma8C-1n0eA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n71 AAC(6')-II

(Enterococcus
faecium) 		PF00583
(Acetyltransf_1) 		4 LEU A 139
GLY A 117
ILE A 136
LYS A 132
 None
 1.09A 4ma8C-1n71A:
0.0		 4ma8C-1n71A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nhy ELONGATION FACTOR
1-GAMMA 1

(Saccharomyces
cerevisiae) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 LEU A  84
GLY A  85
ILE A  97
GLN A 100
 None
 1.17A 4ma8C-1nhyA:
undetectable		 4ma8C-1nhyA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o70 FASCICLIN I

(Drosophila
melanogaster) 		PF02469
(Fasciclin) 		4 GLY A 438
ILE A 385
LYS A 381
GLN A 384
 None
 0.90A 4ma8C-1o70A:
undetectable		 4ma8C-1o70A:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 LEU A 249
GLY A 250
ILE A 546
GLN A 545
 None
 1.16A 4ma8C-1q8yA:
undetectable		 4ma8C-1q8yA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t4b ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Escherichia
coli) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 LEU A 123
GLY A 122
ILE A 110
GLN A 365
 None
 1.12A 4ma8C-1t4bA:
undetectable		 4ma8C-1t4bA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txu RAB5 GDP/GTP
EXCHANGE FACTOR

(Homo sapiens) 		PF02204
(VPS9) 		4 LEU A 146
GLY A 153
ILE A 211
GLN A 210
 LEU  A 146 ( 0.6A)
GLY  A 153 ( 0.0A)
ILE  A 211 ( 0.7A)
GLN  A 210 ( 0.6A)
 1.08A 4ma8C-1txuA:
2.1		 4ma8C-1txuA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlp NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Saccharomyces
cerevisiae) 		PF04095
(NAPRTase) 		4 LEU A  95
GLY A  61
ILE A 101
GLN A 100
 None
 1.12A 4ma8C-1vlpA:
1.1		 4ma8C-1vlpA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wju NEDD8 ULTIMATE
BUSTER-1

(Homo sapiens) 		no annotation 4 GLY A  42
ILE A  64
LYS A  67
GLN A  68
 None
 1.00A 4ma8C-1wjuA:
undetectable		 4ma8C-1wjuA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x4t HYPOTHETICAL PROTEIN
LOC57905

(Mus musculus) 		PF06246
(Isy1) 		4 GLY A  50
ILE A  44
LYS A  40
GLN A  43
 None
 0.82A 4ma8C-1x4tA:
undetectable		 4ma8C-1x4tA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yfm FUMARASE

(Saccharomyces
cerevisiae) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		4 GLY A  75
ILE A  99
LYS A  97
GLN A 100
 None
 1.06A 4ma8C-1yfmA:
undetectable		 4ma8C-1yfmA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9p SUPEROXIDE DISMUTASE
[CU-ZN]

([Haemophilus]
ducreyi) 		PF00080
(Sod_Cu) 		4 LEU A 148
GLY A 174
ILE A  25
LYS A  24
 None
 1.19A 4ma8C-1z9pA:
undetectable		 4ma8C-1z9pA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aff ANTIGEN KI-67
MKI67 FHA DOMAIN
INTERACTING
NUCLEOLAR
PHOSPHOPROTEIN

(Homo sapiens) 		PF00498
(FHA)
PF12196
(hNIFK_binding) 		4 LEU A  22
ILE A  37
LYS B 264
GLN B 265
 None
 1.09A 4ma8C-2affA:
undetectable		 4ma8C-2affA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bw2 BYPASS OF FORESPORE
C

(Bacillus
subtilis) 		PF08955
(BofC_C)
PF08977
(BOFC_N) 		4 LEU A 116
GLY A  76
ILE A 103
LYS A 136
 None
 1.17A 4ma8C-2bw2A:
undetectable		 4ma8C-2bw2A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dbo D-TYROSYL-TRNA(TYR)
DEACYLASE

(Aquifex
aeolicus) 		PF02580
(Tyr_Deacylase) 		4 LEU A  31
GLY A  32
ILE A  42
LYS A  44
 None
 1.18A 4ma8C-2dboA:
undetectable		 4ma8C-2dboA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g5x RIBOSOME-INACTIVATIN
G PROTEIN

(Silene
chalcedonica) 		PF00161
(RIP) 		4 GLY A 218
ILE A 206
LYS A 205
GLN A 209
 None
 1.03A 4ma8C-2g5xA:
undetectable		 4ma8C-2g5xA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)

(Homo sapiens) 		PF03199
(GSH_synthase)
PF03917
(GSH_synth_ATP) 		4 LEU A 338
GLY A 337
ILE A 143
GLN A 142
 None
None
ADP  A 500 (-4.5A)
None
 1.16A 4ma8C-2hgsA:
undetectable		 4ma8C-2hgsA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix5 ACYL-COENZYME A
OXIDASE 4,
PEROXISOMAL

(Arabidopsis
thaliana) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 LEU A 250
GLY A 249
ILE A 298
GLN A 294
 FAD  A1433 ( 4.6A)
None
None
None
 1.09A 4ma8C-2ix5A:
1.2		 4ma8C-2ix5A:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lr4 SPBC2
PROPHAGE-DERIVED
UNCHARACTERIZED
PROTEIN YOLA

(Bacillus
subtilis) 		PF16219
(DUF4879) 		4 GLY A  60
ILE A 106
LYS A 122
GLN A 107
 None
 0.89A 4ma8C-2lr4A:
undetectable		 4ma8C-2lr4A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m6y DNAJ HOMOLOG
SUBFAMILY A MEMBER 1

(Homo sapiens) 		PF00226
(DnaJ) 		4 GLY A  22
ILE A  58
LYS A  54
GLN A  57
 None
 1.05A 4ma8C-2m6yA:
undetectable		 4ma8C-2m6yA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mmb UNCHARACTERIZED
PROTEIN

(Acinetobacter
baumannii) 		PF16309
(DUF4951) 		4 GLY A  40
ILE A  63
LYS A  65
GLN A  66
 None
 1.15A 4ma8C-2mmbA:
undetectable		 4ma8C-2mmbA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nv0 GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT

(Bacillus
subtilis) 		PF01174
(SNO) 		4 LEU A 165
GLY A 166
ILE A 122
LYS A 123
 None
 1.20A 4ma8C-2nv0A:
undetectable		 4ma8C-2nv0A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pi5 DNA-DIRECTED RNA
POLYMERASE

(Escherichia
virus T7) 		PF00940
(RNA_pol)
PF14700
(RPOL_N) 		4 LEU A 791
GLY A 788
ILE A 320
LYS A 318
 None
 1.17A 4ma8C-2pi5A:
3.5		 4ma8C-2pi5A:
8.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pq7 PREDICTED HD
SUPERFAMILY
HYDROLASE

(uncultured
Thermotogales
bacterium) 		PF01966
(HD) 		4 GLY A  95
ILE A  60
LYS A  57
GLN A  56
 None
 1.11A 4ma8C-2pq7A:
undetectable		 4ma8C-2pq7A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbn TERMINASE LARGE
SUBUNIT

(Bacillus phage
SPP1) 		PF17288
(Terminase_3C) 		4 LEU A 265
GLY A 264
ILE A 337
LYS A 332
 None
 1.14A 4ma8C-2wbnA:
undetectable		 4ma8C-2wbnA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wkn FORMAMIDASE

(Delftia
acidovorans) 		PF03069
(FmdA_AmdA) 		4 LEU A  86
GLY A 282
ILE A 292
LYS A 294
 None
 1.17A 4ma8C-2wknA:
undetectable		 4ma8C-2wknA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9y ISWI ONE COMPLEX
PROTEIN 3

(Saccharomyces
cerevisiae) 		PF15612
(WHIM1) 		4 LEU B 589
GLY B 594
ILE B 716
LYS B 578
 None
 1.08A 4ma8C-2y9yB:
undetectable		 4ma8C-2y9yB:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b5q PUTATIVE SULFATASE
YIDJ

(Bacteroides
thetaiotaomicron) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		4 LEU A 332
GLY A 352
LYS A 445
GLN A  79
 None
 1.10A 4ma8C-3b5qA:
undetectable		 4ma8C-3b5qA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8i PA4872 OXALOACETATE
DECARBOXYLASE

(Pseudomonas
aeruginosa) 		PF13714
(PEP_mutase) 		4 LEU A  47
GLY A  48
ILE A  65
GLN A  73
 None
OXL  A 288 ( 3.7A)
None
None
 1.15A 4ma8C-3b8iA:
undetectable		 4ma8C-3b8iA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ct7 D-ALLULOSE-6-PHOSPHA
TE 3-EPIMERASE

(Escherichia
coli) 		PF00834
(Ribul_P_3_epim) 		4 LEU A 199
GLY A 195
ILE A  22
GLN A  18
 None
SO4  A 233 (-3.4A)
None
None
 1.21A 4ma8C-3ct7A:
undetectable		 4ma8C-3ct7A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwg SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 3

(Mus musculus) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind) 		4 LEU A 670
GLY A 604
ILE A 634
GLN A 635
 None
 1.16A 4ma8C-3cwgA:
undetectable		 4ma8C-3cwgA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0z PROTEIN OF UNKNOWN
FUNCTION

([Eubacterium]
rectale) 		PF12939
(DUF3837) 		4 LEU A  33
GLY A  96
ILE A  11
LYS A  13
 None
 0.97A 4ma8C-3e0zA:
undetectable		 4ma8C-3e0zA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3js6 UNCHARACTERIZED PARM
PROTEIN

(Staphylococcus
aureus) 		no annotation 4 LEU A 247
GLY A 246
ILE A 225
LYS A 223
 None
 1.20A 4ma8C-3js6A:
undetectable		 4ma8C-3js6A:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kal HOMOGLUTATHIONE
SYNTHETASE

(Glycine max) 		PF03199
(GSH_synthase)
PF03917
(GSH_synth_ATP) 		4 LEU A 366
GLY A 365
ILE A 168
GLN A 167
 None
None
ADP  A 500 (-4.2A)
None
 1.13A 4ma8C-3kalA:
undetectable		 4ma8C-3kalA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkz NON-STRUCTURAL
PROTEIN 5

(West Nile virus) 		PF01728
(FtsJ) 		4 LEU A 260
GLY A 261
LYS A  95
GLN A  94
 None
 1.14A 4ma8C-3lkzA:
undetectable		 4ma8C-3lkzA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lvr ARF-GAP WITH SH3
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN 3,
ADP-RIBOSYLATION
FACTOR 6

(Homo sapiens;
synthetic
construct) 		PF00025
(Arf)
PF01412
(ArfGap)
PF12796
(Ank_2) 		4 LEU E 166
GLY E 165
ILE E  29
LYS E  32
 None
 1.08A 4ma8C-3lvrE:
undetectable		 4ma8C-3lvrE:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my7 ALCOHOL
DEHYDROGENASE/ACETAL
DEHYDE DEHYDROGENASE

(Vibrio
parahaemolyticus) 		PF00171
(Aldedh) 		4 LEU A 287
GLY A 290
ILE A 363
LYS A 215
 None
 0.95A 4ma8C-3my7A:
undetectable		 4ma8C-3my7A:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nqw CG11900

(Drosophila
melanogaster) 		PF13328
(HD_4) 		4 LEU A 158
ILE A 106
LYS A 102
GLN A 105
 None
None
SO4  A 301 (-2.8A)
None
 0.88A 4ma8C-3nqwA:
undetectable		 4ma8C-3nqwA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzp ARGININE
DECARBOXYLASE

(Campylobacter
jejuni) 		PF02784
(Orn_Arg_deC_N) 		4 GLY A 517
ILE A  55
LYS A  57
GLN A  58
 None
None
None
SO4  A 702 ( 4.2A)
 1.04A 4ma8C-3nzpA:
2.8		 4ma8C-3nzpA:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqv RCL1 PROTEIN

(Kluyveromyces
lactis) 		PF01137
(RTC)
PF05189
(RTC_insert) 		4 LEU A  44
GLY A  43
ILE A  32
LYS A  31
 None
 1.04A 4ma8C-3pqvA:
undetectable		 4ma8C-3pqvA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pt7 HEMOGLOBIN II

(Phacoides
pectinatus) 		PF00042
(Globin) 		4 GLY A 137
ILE A  11
LYS A   8
GLN A   7
 None
 1.17A 4ma8C-3pt7A:
2.5		 4ma8C-3pt7A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd9 QSOX FROM
TRYPANOSOMA BRUCEI
(TBQSOX)

(Trypanosoma
brucei) 		PF00085
(Thioredoxin)
PF04777
(Evr1_Alr) 		4 LEU A  86
GLY A  85
ILE A 181
LYS A 177
 None
 1.17A 4ma8C-3qd9A:
undetectable		 4ma8C-3qd9A:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ro2 G-PROTEIN-SIGNALING
MODULATOR 2

(Mus musculus) 		PF13176
(TPR_7)
PF13424
(TPR_12) 		4 LEU A 177
GLY A 142
ILE A 115
GLN A 119
 None
None
None
GOL  A   1 (-3.4A)
 1.15A 4ma8C-3ro2A:
undetectable		 4ma8C-3ro2A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s8d COENZYME A
TRANSFERASE

(Yersinia pestis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		4 LEU A 255
GLY A 254
ILE A 320
GLN A 224
 None
 1.18A 4ma8C-3s8dA:
undetectable		 4ma8C-3s8dA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tdg PUTATIVE
UNCHARACTERIZED
PROTEIN

(Helicobacter
pylori) 		no annotation 4 LEU A  77
GLY A  88
ILE A  39
LYS A  45
 None
 1.11A 4ma8C-3tdgA:
undetectable		 4ma8C-3tdgA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8x TRANSFERRIN-BINDING
PROTEIN 1

(Neisseria
meningitidis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 GLY A 211
ILE A 190
LYS A 914
GLN A 191
 None
 1.16A 4ma8C-3v8xA:
undetectable		 4ma8C-3v8xA:
7.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zcw KINESIN-LIKE PROTEIN
KIF11

(Homo sapiens) 		PF00225
(Kinesin) 		4 LEU A 295
GLY A 296
ILE A 332
LYS A  18
 4A2  A1366 (-4.1A)
4A2  A1366 (-3.4A)
4A2  A1366 (-3.9A)
None
 1.00A 4ma8C-3zcwA:
undetectable		 4ma8C-3zcwA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1n CARBON MONOXIDE
DEHYDROGENASE
CORRINOID/IRON-SULFU
R PROTEIN, GAMMA
SUBUNIT

(Carboxydothermus
hydrogenoformans) 		PF03599
(CdhD)
PF04060
(FeS) 		4 LEU A  39
GLY A  38
ILE A   8
LYS A   2
 None
 1.21A 4ma8C-4c1nA:
undetectable		 4ma8C-4c1nA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cgy DNA TOPOISOMERASE
3-ALPHA

(Homo sapiens) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		4 LEU A 553
GLY A 552
ILE A 542
LYS A 345
 None
 1.09A 4ma8C-4cgyA:
undetectable		 4ma8C-4cgyA:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ciu CHAPERONE PROTEIN
CLPB

(Escherichia
coli) 		PF00004
(AAA)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		4 LEU A 766
GLY A 767
ILE A 571
GLN A 573
 None
None
ADP  A 902 (-4.5A)
None
 1.20A 4ma8C-4ciuA:
2.7		 4ma8C-4ciuA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyk AMIDOHYDROLASE

(Pseudomonas
aeruginosa) 		PF01979
(Amidohydro_1) 		4 GLY A 174
ILE A 207
LYS A 203
GLN A 206
 None
 0.86A 4ma8C-4dykA:
undetectable		 4ma8C-4dykA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fme ADP-RIBOSYLATION
FACTOR 6

(Homo sapiens) 		PF00025
(Arf) 		4 LEU C 166
GLY C 165
ILE C  29
LYS C  32
 None
 1.07A 4ma8C-4fmeC:
undetectable		 4ma8C-4fmeC:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl2 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		4 GLY A 795
ILE A 775
LYS A 772
GLN A 771
 None
None
None
G  D   7 ( 4.0A)
 1.14A 4ma8C-4gl2A:
undetectable		 4ma8C-4gl2A:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h16 SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		4 LEU A 215
GLY A 216
ILE A 138
GLN A 139
 None
None
None
P6G  A 305 (-3.9A)
 1.12A 4ma8C-4h16A:
undetectable		 4ma8C-4h16A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hmy ADP-RIBOSYLATION
FACTOR 1

(Homo sapiens) 		PF00025
(Arf) 		4 LEU C 170
GLY C 169
ILE C  33
LYS C  36
 None
 1.11A 4ma8C-4hmyC:
undetectable		 4ma8C-4hmyC:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvf RHAMNOSE ABC
TRANSPORTER,
PERIPLASMIC
RHAMNOSE-BINDING
PROTEIN

(Kribbella
flavida) 		PF13407
(Peripla_BP_4) 		4 LEU A 299
GLY A 280
ILE A 169
GLN A 163
 None
 1.19A 4ma8C-4kvfA:
undetectable		 4ma8C-4kvfA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l1g PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE

(Bacillus cereus) 		PF01522
(Polysacc_deac_1) 		4 GLY A 214
ILE A 242
LYS A 241
GLN A 245
 None
 1.12A 4ma8C-4l1gA:
undetectable		 4ma8C-4l1gA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n7r GLUTAMYL-TRNA
REDUCTASE 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00745
(GlutR_dimer)
PF01488
(Shikimate_DH)
PF05201
(GlutR_N) 		4 LEU A 201
GLY A 200
ILE A 425
GLN A 423
 None
 1.09A 4ma8C-4n7rA:
0.7		 4ma8C-4n7rA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o0m CIRCADIAN CLOCK
PROTEIN KINASE KAIC

(Thermosynechococcus
elongatus) 		PF06745
(ATPase) 		4 GLY A 355
ILE A 362
LYS A 364
GLN A 361
 None
 1.13A 4ma8C-4o0mA:
undetectable		 4ma8C-4o0mA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5v IRON-DEPENDENT
TRANSCRIPTION
REPRESSOR RELATED
PROTEIN

(Thermoplasma
acidophilum) 		PF02742
(Fe_dep_repr_C)
PF04023
(FeoA) 		4 GLY A  26
ILE A  18
LYS A  16
GLN A  19
 None
None
FE2  A 302 ( 4.3A)
None
 1.04A 4ma8C-4o5vA:
undetectable		 4ma8C-4o5vA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4om9 SERINE PROTEASE PET

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		4 LEU A 311
GLY A 315
ILE A 270
LYS A 274
 None
 1.08A 4ma8C-4om9A:
undetectable		 4ma8C-4om9A:
7.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]

(Rattus
norvegicus) 		PF00821
(PEPCK_C)
PF17297
(PEPCK_N) 		4 LEU A 184
GLY A 185
ILE A 158
LYS A 191
 None
 1.21A 4ma8C-4ox2A:
1.9		 4ma8C-4ox2A:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ph1 BLV CAPSID

(Bovine leukemia
virus) 		PF00607
(Gag_p24) 		4 LEU A 199
GLY A 196
ILE A 169
GLN A 152
 None
 1.00A 4ma8C-4ph1A:
undetectable		 4ma8C-4ph1A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q5q GLUTATHIONE
S-TRANSFERASE

(Dermatophagoides
pteronyssinus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 LEU A  20
ILE A 199
LYS A 201
GLN A 202
 None
 1.10A 4ma8C-4q5qA:
undetectable		 4ma8C-4q5qA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7p UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE

(Homo sapiens) 		PF01704
(UDPGP) 		4 LEU A 383
GLY A 384
ILE A  92
LYS A  91
 None
 1.18A 4ma8C-4r7pA:
undetectable		 4ma8C-4r7pA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uob ENDONUCLEASE III-3

(Deinococcus
radiodurans) 		PF00730
(HhH-GPD) 		4 LEU A 128
GLY A 127
ILE A 186
LYS A 182
 None
 1.13A 4ma8C-4uobA:
undetectable		 4ma8C-4uobA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usq PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE

(Cellvibrio sp.
BR) 		PF13738
(Pyr_redox_3) 		4 LEU A  59
GLY A  55
ILE A 187
GLN A 186
 None
 1.21A 4ma8C-4usqA:
undetectable		 4ma8C-4usqA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wql 2''-AMINOGLYCOSIDE
NUCLEOTIDYLTRANSFERA
SE

(Klebsiella
pneumoniae) 		PF10706
(Aminoglyc_resit) 		4 GLY A  28
ILE A   9
LYS A   3
GLN A   5
 IPA  A 204 (-3.3A)
None
None
None
 1.20A 4ma8C-4wqlA:
undetectable		 4ma8C-4wqlA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzz PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Lachnoclostridium
phytofermentans) 		PF13407
(Peripla_BP_4) 		4 LEU A 292
GLY A 270
ILE A 159
GLN A 153
 RAM  A 401 ( 4.6A)
None
None
RAM  A 401 (-4.1A)
 0.99A 4ma8C-4wzzA:
undetectable		 4ma8C-4wzzA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xpr ALPHA-GLUCOSIDASE

(Pseudopedobacter
saltans) 		PF01055
(Glyco_hydro_31)
PF17137
(DUF5110) 		4 LEU A  50
GLY A 422
ILE A 154
GLN A 392
 None
 1.15A 4ma8C-4xprA:
undetectable		 4ma8C-4xprA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yea COPPER TRANSPORT
PROTEIN ATOX1

(Homo sapiens) 		PF00403
(HMA) 		4 LEU A  26
GLY A  27
ILE A  42
LYS A   2
 None
 1.20A 4ma8C-4yeaA:
undetectable		 4ma8C-4yeaA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zzq CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Dictyostelium
discoideum) 		PF00840
(Glyco_hydro_7) 		4 LEU A 362
GLY A 359
ILE A 305
LYS A 306
 None
 1.10A 4ma8C-4zzqA:
undetectable		 4ma8C-4zzqA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bsw 4-COUMARATE--COA
LIGASE 2

(Nicotiana
tabacum) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 LEU A 100
GLY A 101
ILE A  80
LYS A 126
 None
 1.13A 4ma8C-5bswA:
undetectable		 4ma8C-5bswA:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d8w ENDOGLUCANASE

(Ganoderma
lucidum) 		PF00150
(Cellulase) 		4 LEU A 304
GLY A 305
ILE A 158
LYS A 156
 None
 1.12A 4ma8C-5d8wA:
undetectable		 4ma8C-5d8wA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4i CONTACTIN-5

(Mus musculus) 		PF07679
(I-set)
PF13927
(Ig_3) 		4 LEU A 286
GLY A 264
ILE A 255
LYS A 257
 None
 1.21A 4ma8C-5e4iA:
undetectable		 4ma8C-5e4iA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fu7 CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1
CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 2

(Homo sapiens) 		PF04054
(Not1)
PF04153
(NOT2_3_5) 		4 LEU B 360
GLY B 359
ILE A2349
LYS A2351
 None
 1.20A 4ma8C-5fu7B:
undetectable		 4ma8C-5fu7B:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hd2 PARASPORAL CRYSTAL
PROTEIN

(Bacillus
thuringiensis) 		PF03318
(ETX_MTX2) 		4 LEU A  62
GLY A 178
ILE A 120
GLN A  60
 None
 0.93A 4ma8C-5hd2A:
undetectable		 4ma8C-5hd2A:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5huu ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
[UDP-FORMING]

(Candida
albicans) 		PF00982
(Glyco_transf_20) 		4 GLY A  51
ILE A 129
LYS A 131
GLN A 132
 None
 0.98A 4ma8C-5huuA:
undetectable		 4ma8C-5huuA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6q CELL WALL BINDING
PROTEIN CWP8

(Clostridioides
difficile) 		PF04122
(CW_binding_2) 		4 GLY A 377
ILE A 413
LYS A 415
GLN A 416
 None
 1.07A 4ma8C-5j6qA:
undetectable		 4ma8C-5j6qA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lwg VP3

(Israeli acute
paralysis virus) 		no annotation 4 GLY C  84
ILE C  81
LYS C  79
GLN C 175
 None
 1.16A 4ma8C-5lwgC:
undetectable		 4ma8C-5lwgC:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mfd YIIIM''6AII

(synthetic
construct) 		PF00514
(Arm) 		4 GLY A 251
ILE A 290
LYS A 298
GLN A 297
 None
 0.92A 4ma8C-5mfdA:
undetectable		 4ma8C-5mfdA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mms CYSTATHIONINE
BETA-SYNTHASE

(Homo sapiens) 		PF00291
(PALP) 		4 LEU A 154
GLY A 153
ILE A 122
GLN A 222
 None
 1.21A 4ma8C-5mmsA:
undetectable		 4ma8C-5mmsA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngk GLUCOSYLCERAMIDASE

(Bacteroides
thetaiotaomicron) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		4 LEU A 263
GLY A 264
ILE A 220
LYS A 218
 None
 1.05A 4ma8C-5ngkA:
undetectable		 4ma8C-5ngkA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5i ROUNDABOUT HOMOLOG 1

(Homo sapiens) 		no annotation 4 GLY A 470
ILE A 512
LYS A 503
GLN A 511
 None
 1.09A 4ma8C-5o5iA:
undetectable		 4ma8C-5o5iA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o6y PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE

(Bacillus cereus) 		no annotation 4 GLY B 214
ILE B 242
LYS B 241
GLN B 245
 None
 1.11A 4ma8C-5o6yB:
undetectable		 4ma8C-5o6yB:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oes GLUTATHIONE
SYNTHETASE

(Solanum
tuberosum) 		no annotation 4 LEU A 350
GLY A 349
ILE A 152
GLN A 151
 None
None
ADP  A 501 (-3.9A)
None
 1.15A 4ma8C-5oesA:
undetectable		 4ma8C-5oesA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uvr PILO PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 4 LEU A 205
GLY A 204
ILE A 142
GLN A 138
 None
 1.18A 4ma8C-5uvrA:
undetectable		 4ma8C-5uvrA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vjw RHIZOBIALES-LIKE
PHOSPHATASE 2

(Arabidopsis
thaliana) 		no annotation 4 GLY A  79
ILE A 239
LYS A 238
GLN A 129
 None
None
WO4  A 404 (-3.5A)
WO4  A 404 ( 4.8A)
 1.05A 4ma8C-5vjwA:
undetectable		 4ma8C-5vjwA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgj PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT ALPHA
ISOFORM

(Homo sapiens) 		no annotation 4 GLY A   8
ILE A 718
LYS A 720
GLN A 721
 None
 1.05A 4ma8C-5xgjA:
undetectable		 4ma8C-5xgjA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yrz HICB

(Streptococcus
pneumoniae) 		no annotation 4 LEU A 108
GLY A 109
ILE A 143
LYS A 147
 None
 1.18A 4ma8C-5yrzA:
undetectable		 4ma8C-5yrzA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yzc GLYCOPROTEIN
F1,MEASLES VIRUS
FUSION PROTEIN

(Measles
morbillivirus) 		no annotation 4 LEU B 123
GLY B 124
ILE B 131
GLN B 130
 None
 0.99A 4ma8C-5yzcB:
undetectable		 4ma8C-5yzcB:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fb3 TENEURIN-2

(Gallus gallus) 		no annotation 4 GLY A2161
ILE A2170
LYS A2180
GLN A2169
 None
 1.21A 4ma8C-6fb3A:
undetectable		 4ma8C-6fb3A:
18.10