SIMILAR PATTERNS OF AMINO ACIDS FOR 4MA7_A_P2ZA301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1adq IGM-LAMBDA RF-AN FAB
(HEAVY CHAIN)

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H  80
TYR H  90
ILE H 107
VAL H  12
 None
 0.74A 4ma7A-1adqH:
undetectable		 4ma7A-1adqH:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cyg CYCLODEXTRIN
GLUCANOTRANSFERASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		4 VAL A 313
LEU A 314
TYR A 402
VAL A 426
 None
 0.97A 4ma7A-1cygA:
undetectable		 4ma7A-1cygA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ddz CARBONIC ANHYDRASE

(Porphyridium
purpureum) 		PF00484
(Pro_CA) 		5 VAL A 197
TYR A 194
ILE A 477
GLN A 189
THR A 269
 None
 1.20A 4ma7A-1ddzA:
undetectable		 4ma7A-1ddzA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eqc EXO-(B)-(1,3)-GLUCAN
ASE

(Candida
albicans) 		PF00150
(Cellulase) 		4 VAL A  25
TYR A  52
VAL A 163
THR A 164
 None
 0.74A 4ma7A-1eqcA:
0.0		 4ma7A-1eqcA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fa7 GLYOXALASE I

(Escherichia
coli) 		PF00903
(Glyoxalase) 		4 VAL A  23
LEU A  24
ILE A  75
THR A  97
 None
 0.94A 4ma7A-1fa7A:
undetectable		 4ma7A-1fa7A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fzt PHOSPHOGLYCERATE
MUTASE

(Schizosaccharomyces
pombe) 		PF00300
(His_Phos_1) 		5 VAL A 158
LEU A  10
TYR A 195
ILE A 171
VAL A 140
 None
 1.41A 4ma7A-1fztA:
undetectable		 4ma7A-1fztA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0d PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE

(Pagrus major) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		4 VAL A 577
TYR A 400
ILE A 399
VAL A 302
 None
 0.86A 4ma7A-1g0dA:
0.0		 4ma7A-1g0dA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hcy ARTHROPODAN
HEMOCYANIN

(Panulirus
interruptus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 TYR A 431
ILE A 188
VAL A 195
THR A 196
 None
 0.85A 4ma7A-1hcyA:
undetectable		 4ma7A-1hcyA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hds HEMOGLOBIN S (DEOXY)
(ALPHA CHAIN)
HEMOGLOBIN S (DEOXY)
(BETA CHAIN)

(Odocoileus
virginianus) 		PF00042
(Globin) 		4 VAL A  96
LEU A 100
GLN B 130
VAL B 133
 None
 0.94A 4ma7A-1hdsA:
2.5		 4ma7A-1hdsA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1he3 BILIVERDIN IX BETA
REDUCTASE

(Homo sapiens) 		PF13460
(NAD_binding_10) 		4 LEU A  75
ILE A  72
VAL A  65
THR A  64
 NAP  A1206 (-4.6A)
None
None
None
 0.93A 4ma7A-1he3A:
undetectable		 4ma7A-1he3A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hlg LIPASE, GASTRIC

(Homo sapiens) 		PF00561
(Abhydrolase_1) 		4 VAL A  94
LEU A  63
ILE A 357
VAL A 366
 None
 0.96A 4ma7A-1hlgA:
undetectable		 4ma7A-1hlgA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ij9 VASCULAR CELL
ADHESION PROTEIN 1

(Homo sapiens) 		PF05790
(C2-set)
PF07679
(I-set) 		5 VAL A 195
LEU A 193
ILE A  97
VAL A 156
THR A 157
 None
 1.33A 4ma7A-1ij9A:
undetectable		 4ma7A-1ij9A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js8 HEMOCYANIN

(Enteroctopus
dofleini) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 LEU A2574
TYR A2699
ILE A2591
VAL A2527
 None
 0.87A 4ma7A-1js8A:
undetectable		 4ma7A-1js8A:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k8q TRIACYLGLYCEROL
LIPASE, GASTRIC

(Canis lupus) 		PF00561
(Abhydrolase_1) 		4 VAL A  94
LEU A  63
ILE A 357
VAL A 366
 None
 0.95A 4ma7A-1k8qA:
undetectable		 4ma7A-1k8qA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lnq POTASSIUM CHANNEL
RELATED PROTEIN

(Methanothermobacter
thermautotrophicus) 		PF02080
(TrkA_C)
PF02254
(TrkA_N)
PF07885
(Ion_trans_2) 		4 VAL A 278
LEU A 275
TYR A 333
VAL A 291
 None
 0.97A 4ma7A-1lnqA:
2.1		 4ma7A-1lnqA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhz METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylosinus
trichosporium) 		PF02332
(Phenol_Hydrox) 		4 VAL D 285
LEU D 346
ILE D 426
THR D 449
 None
 0.97A 4ma7A-1mhzD:
undetectable		 4ma7A-1mhzD:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p3w CYSTEINE DESULFURASE

(Escherichia
coli) 		no annotation 4 LEU B 134
ILE B 150
GLN B 161
VAL B 159
 None
 0.78A 4ma7A-1p3wB:
undetectable		 4ma7A-1p3wB:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT

(Acidaminococcus
fermentans) 		PF01039
(Carboxyl_trans) 		4 TYR A 437
ILE A 436
VAL A 398
THR A 399
 None
 0.90A 4ma7A-1pixA:
undetectable		 4ma7A-1pixA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pss PHOTOSYNTHETIC
REACTION CENTER

(Rhodobacter
sphaeroides) 		PF00124
(Photo_RC) 		4 LEU L 189
ILE M 270
VAL M 276
THR M 277
 U10  L 272 ( 4.1A)
None
None
BPH  M   5 (-3.3A)
 0.96A 4ma7A-1pssL:
undetectable		 4ma7A-1pssL:
17.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qlz PRION PROTEIN

(Homo sapiens) 		PF00377
(Prion) 		5 TYR A 128
TYR A 162
ILE A 182
VAL A 189
THR A 190
 None
 1.14A 4ma7A-1qlzA:
14.5		 4ma7A-1qlzA:
88.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qnr ENDO-1,4-B-D-MANNANA
SE

(Trichoderma
reesei) 		PF00150
(Cellulase) 		4 VAL A 151
LEU A  89
ILE A  70
VAL A  61
 None
 0.90A 4ma7A-1qnrA:
undetectable		 4ma7A-1qnrA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qo8 FLAVOCYTOCHROME C3
FUMARATE REDUCTASE

(Shewanella
frigidimarina) 		PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2) 		5 VAL A 378
LEU A 420
ILE A 415
VAL A 494
THR A 362
 None
 1.49A 4ma7A-1qo8A:
undetectable		 4ma7A-1qo8A:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qpw PORCINE HEMOGLOBIN
(ALPHA SUBUNIT)
PORCINE HEMOGLOBIN
(BETA SUBUNIT)

(Sus scrofa) 		PF00042
(Globin) 		4 VAL A  96
LEU A 100
GLN B 131
VAL B 134
 None
 0.56A 4ma7A-1qpwA:
2.8		 4ma7A-1qpwA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s4e GALACTOKINASE

(Pyrococcus
furiosus) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		4 VAL A 280
LEU A 274
ILE A  15
VAL A  12
 None
 0.95A 4ma7A-1s4eA:
undetectable		 4ma7A-1s4eA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suu DNA GYRASE SUBUNIT A

(Borreliella
burgdorferi) 		PF03989
(DNA_gyraseA_C) 		4 VAL A 768
LEU A 766
TYR A 526
GLN A 523
 None
 0.83A 4ma7A-1suuA:
undetectable		 4ma7A-1suuA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tii HEAT LABILE
ENTEROTOXIN TYPE IIB

(Escherichia
coli) 		PF01375
(Enterotoxin_a) 		4 VAL A  95
LEU A  99
TYR A 102
THR C 201
 None
 0.89A 4ma7A-1tiiA:
undetectable		 4ma7A-1tiiA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u70 DIHYDROFOLATE
REDUCTASE

(Mus musculus) 		PF00186
(DHFR_1) 		4 LEU A 153
TYR A 156
TYR A 182
VAL A  10
 None
 0.90A 4ma7A-1u70A:
undetectable		 4ma7A-1u70A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u71 DIHYDROFOLATE
REDUCTASE

(Homo sapiens) 		PF00186
(DHFR_1) 		4 LEU A 153
TYR A 156
TYR A 182
VAL A  10
 None
 0.89A 4ma7A-1u71A:
undetectable		 4ma7A-1u71A:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua4 ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
furiosus) 		PF04587
(ADP_PFK_GK) 		5 VAL A 358
LEU A 362
TYR A 347
VAL A 323
THR A 324
 None
None
AMP  A1456 (-4.8A)
None
None
 1.33A 4ma7A-1ua4A:
undetectable		 4ma7A-1ua4A:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umg 385AA LONG CONSERVED
HYPOTHETICAL PROTEIN

(Sulfurisphaera
tokodaii) 		PF01950
(FBPase_3) 		4 VAL A  33
LEU A  34
ILE A  58
VAL A 113
 None
 0.93A 4ma7A-1umgA:
undetectable		 4ma7A-1umgA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wgq ETHANOL DECREASED 4
FYVE, RHOGEF AND PH
DOMAIN CONTAINING 6

(Mus musculus) 		PF00169
(PH) 		4 VAL A  58
LEU A  73
TYR A  81
GLN A  51
 None
 0.97A 4ma7A-1wgqA:
undetectable		 4ma7A-1wgqA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wh6 HOMEOBOX PROTEIN
CUX-2

(Homo sapiens) 		PF02376
(CUT) 		4 VAL A  26
LEU A  30
ILE A  39
VAL A  88
 None
 0.98A 4ma7A-1wh6A:
undetectable		 4ma7A-1wh6A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wvh TENSIN

(Gallus gallus) 		PF08416
(PTB) 		4 VAL A1713
TYR A1670
ILE A1655
VAL A1646
 None
 0.93A 4ma7A-1wvhA:
undetectable		 4ma7A-1wvhA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xpg 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Thermotoga
maritima) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		4 VAL A 218
LEU A 222
ILE A 196
THR A  70
 None
 0.93A 4ma7A-1xpgA:
undetectable		 4ma7A-1xpgA:
10.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xyu MAJOR PRION PROTEIN

(Ovis aries) 		PF00377
(Prion) 		4 LEU A 130
ILE A 182
GLN A 186
THR A 191
 None
 0.81A 4ma7A-1xyuA:
15.6		 4ma7A-1xyuA:
89.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xyu MAJOR PRION PROTEIN

(Ovis aries) 		PF00377
(Prion) 		4 LEU A 130
ILE A 182
GLN A 186
VAL A 189
 None
 0.90A 4ma7A-1xyuA:
15.6		 4ma7A-1xyuA:
89.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xyu MAJOR PRION PROTEIN

(Ovis aries) 		PF00377
(Prion) 		5 TYR A 128
TYR A 162
ILE A 182
VAL A 189
THR A 190
 None
 0.81A 4ma7A-1xyuA:
15.6		 4ma7A-1xyuA:
89.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yp4 GLUCOSE-1-PHOSPHATE
ADENYLYLTRANSFERASE
SMALL SUBUNIT

(Solanum
tuberosum) 		PF00483
(NTP_transferase) 		4 LEU A 130
TYR A  71
ILE A  24
VAL A 136
 None
 0.97A 4ma7A-1yp4A:
undetectable		 4ma7A-1yp4A:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3i SIMILAR TO
RAD54-LIKE

(Danio rerio) 		PF00176
(SNF2_N)
PF00271
(Helicase_C) 		4 TYR X 611
ILE X 402
GLN X 404
VAL X 725
 None
 0.89A 4ma7A-1z3iX:
undetectable		 4ma7A-1z3iX:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aan AURACYANIN A

(Chloroflexus
aurantiacus) 		PF00127
(Copper-bind) 		5 VAL A 138
LEU A 136
ILE A  23
VAL A 109
THR A 110
 None
 1.16A 4ma7A-2aanA:
undetectable		 4ma7A-2aanA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2anr NEURO-ONCOLOGICAL
VENTRAL ANTIGEN 1

(Homo sapiens) 		PF00013
(KH_1) 		4 VAL A  10
LEU A   8
ILE A  62
THR A  35
 None
 0.91A 4ma7A-2anrA:
undetectable		 4ma7A-2anrA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b7h HEMOGLOBIN ALPHA
CHAIN
HEMOGLOBIN BETA
CHAIN

(Cerdocyon thous) 		PF00042
(Globin) 		4 VAL A  96
LEU A 100
GLN B 131
VAL B 134
 None
 0.79A 4ma7A-2b7hA:
2.9		 4ma7A-2b7hA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e8y AMYX PROTEIN

(Bacillus
subtilis) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 LEU A 645
TYR A 643
VAL A 706
THR A 705
 None
 0.90A 4ma7A-2e8yA:
undetectable		 4ma7A-2e8yA:
12.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fj3 MAJOR PRION PROTEIN

(Oryctolagus
cuniculus) 		PF00377
(Prion) 		4 TYR A 161
ILE A 181
GLN A 185
THR A 190
 None
 0.77A 4ma7A-2fj3A:
11.5		 4ma7A-2fj3A:
89.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gq3 MALATE SYNTHASE G

(Mycobacterium
tuberculosis) 		PF01274
(Malate_synthase) 		4 LEU A 644
ILE A 468
GLN A 642
THR A 710
 None
 0.83A 4ma7A-2gq3A:
undetectable		 4ma7A-2gq3A:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gtx METHIONINE
AMINOPEPTIDASE

(Escherichia
coli) 		PF00557
(Peptidase_M24) 		4 VAL A 115
TYR A  31
ILE A  44
VAL A  69
 None
 0.90A 4ma7A-2gtxA:
undetectable		 4ma7A-2gtxA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ha9 UPF0210 PROTEIN
SP0239

(Streptococcus
pneumoniae) 		PF05167
(DUF711) 		4 VAL A   6
LEU A 251
ILE A  20
VAL A  58
 None
 0.91A 4ma7A-2ha9A:
undetectable		 4ma7A-2ha9A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i1j MOESIN

(Spodoptera
frugiperda) 		PF00373
(FERM_M)
PF00769
(ERM)
PF09379
(FERM_N)
PF09380
(FERM_C) 		4 VAL A 130
ILE A 110
VAL A 157
THR A 158
 None
 0.94A 4ma7A-2i1jA:
undetectable		 4ma7A-2i1jA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2icy PROBABLE
UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2

(Arabidopsis
thaliana) 		PF01704
(UDPGP) 		4 VAL A  82
LEU A  80
ILE A 237
VAL A  66
 None
 0.96A 4ma7A-2icyA:
undetectable		 4ma7A-2icyA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2id0 EXORIBONUCLEASE 2

(Escherichia
coli) 		PF00575
(S1)
PF00773
(RNB)
PF08206
(OB_RNB) 		4 VAL A  26
LEU A  36
TYR A  44
ILE A  64
 None
 0.95A 4ma7A-2id0A:
undetectable		 4ma7A-2id0A:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j66 BTRK

(Bacillus
circulans) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 LEU A  65
TYR A  45
ILE A 267
THR A  38
 None
 0.84A 4ma7A-2j66A:
undetectable		 4ma7A-2j66A:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l26 UNCHARACTERIZED
PROTEIN
RV0899/MT0922

(Mycobacterium
tuberculosis) 		PF00691
(OmpA)
PF04972
(BON) 		4 VAL A 281
LEU A 285
VAL A 218
THR A 219
 None
 0.93A 4ma7A-2l26A:
undetectable		 4ma7A-2l26A:
17.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2n53 MAJOR PRION PROTEIN

(Ovis aries) 		PF00377
(Prion) 		5 LEU A 133
ILE A 185
GLN A 189
VAL A 192
THR A 193
 None
 0.64A 4ma7A-2n53A:
7.3		 4ma7A-2n53A:
89.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2n53 MAJOR PRION PROTEIN

(Ovis aries) 		PF00377
(Prion) 		5 LEU A 133
TYR A 131
ILE A 185
VAL A 192
THR A 193
 None
 1.50A 4ma7A-2n53A:
7.3		 4ma7A-2n53A:
89.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4h VESTITONE REDUCTASE

(Medicago sativa) 		PF01370
(Epimerase) 		4 VAL X 105
LEU X 109
ILE X 184
THR X 188
 None
 0.98A 4ma7A-2p4hX:
undetectable		 4ma7A-2p4hX:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase)
PF16918
(PknG_TPR)
PF16919
(PknG_rubred) 		4 VAL A 518
LEU A 513
TYR A 541
THR A 579
 None
 0.93A 4ma7A-2pziA:
undetectable		 4ma7A-2pziA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q8h [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1

(Homo sapiens) 		PF02518
(HATPase_c)
PF10436
(BCDHK_Adom3) 		4 VAL A 177
LEU A 181
TYR A 357
ILE A 361
 None
 0.94A 4ma7A-2q8hA:
undetectable		 4ma7A-2q8hA:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca) 		PF04672
(Methyltransf_19) 		4 VAL A 109
LEU A  83
TYR A 181
VAL A 173
 None
 0.98A 4ma7A-2qe6A:
undetectable		 4ma7A-2qe6A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkx BIFUNCTIONAL PROTEIN
GLMU

(Mycobacterium
tuberculosis) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		4 VAL A  93
LEU A 210
ILE A 164
VAL A 224
 None
GN1  A 401 ( 4.9A)
None
None
 0.92A 4ma7A-2qkxA:
undetectable		 4ma7A-2qkxA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qny 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Mycobacterium
tuberculosis) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 VAL A 242
LEU A 301
ILE A 174
VAL A 136
 None
 0.96A 4ma7A-2qnyA:
undetectable		 4ma7A-2qnyA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzu PUTATIVE SULFATASE
YIDJ

(Bacteroides
fragilis) 		PF00884
(Sulfatase) 		5 VAL A 388
LEU A 354
ILE A  70
GLN A 399
THR A 381
 None
 1.46A 4ma7A-2qzuA:
undetectable		 4ma7A-2qzuA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v2f PENICILLIN BINDING
PROTEIN 1A

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		4 VAL F 538
LEU F 539
ILE F 622
VAL F 595
 None
 0.91A 4ma7A-2v2fF:
undetectable		 4ma7A-2v2fF:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5n CATION-INDEPENDENT
MANNOSE-6-PHOSPHATE
RECEPTOR

(Homo sapiens) 		PF00878
(CIMR) 		4 VAL A1786
LEU A1761
TYR A1741
ILE A1732
 None
 0.95A 4ma7A-2v5nA:
undetectable		 4ma7A-2v5nA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vmf BETA-MANNOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2) 		4 VAL A 141
LEU A 145
ILE A  96
THR A  93
 None
 0.87A 4ma7A-2vmfA:
undetectable		 4ma7A-2vmfA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrk ALPHA-L-ARABINOFURAN
OSIDASE

(Thermobacillus
xylanilyticus) 		PF06964
(Alpha-L-AF_C) 		4 VAL A  14
LEU A 384
ILE A 416
VAL A 440
 None
 0.89A 4ma7A-2vrkA:
undetectable		 4ma7A-2vrkA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsa MOSQUITOCIDAL TOXIN

(Lysinibacillus
sphaericus) 		PF05588
(Botulinum_HA-17)
PF14200
(RicinB_lectin_2) 		4 VAL A 549
ILE A 577
VAL A 445
THR A 444
 None
 0.93A 4ma7A-2vsaA:
undetectable		 4ma7A-2vsaA:
8.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1p
AQUAPORIN PIP2-7 7

(Komagataella
pastoris) 		PF00230
(MIP) 		4 VAL A 115
LEU A 119
TYR A  31
THR A 197
 None
 0.80A 4ma7A-2w1pA:
undetectable		 4ma7A-2w1pA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w47 LIPOLYTIC ENZYME,
G-D-S-L

(Ruminiclostridium
thermocellum) 		PF16990
(CBM_35) 		4 VAL A  32
TYR A 125
ILE A   6
VAL A  46
 None
 0.83A 4ma7A-2w47A:
undetectable		 4ma7A-2w47A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbx CADHERIN-23

(Mus musculus) 		PF00028
(Cadherin) 		4 VAL A  26
LEU A  67
ILE A  98
THR A  75
 None
 0.94A 4ma7A-2wbxA:
undetectable		 4ma7A-2wbxA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdq LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N

(Thermosynechococcus
elongatus) 		PF00148
(Oxidored_nitro) 		4 VAL A 209
LEU A 213
ILE A 283
THR A 304
 None
 0.96A 4ma7A-2xdqA:
undetectable		 4ma7A-2xdqA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhe UNC18

(Monosiga
brevicollis) 		PF00995
(Sec1) 		4 VAL A 471
LEU A 472
ILE A 361
VAL A 392
 None
 0.92A 4ma7A-2xheA:
2.4		 4ma7A-2xheA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhg TYROCIDINE
SYNTHETASE A

(Brevibacillus
brevis) 		PF00668
(Condensation) 		5 VAL A 365
LEU A 411
TYR A 428
TYR A 433
VAL A 224
 GOL  A1468 (-3.9A)
None
None
None
None
 1.35A 4ma7A-2xhgA:
undetectable		 4ma7A-2xhgA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xqr INVERTASE INHIBITOR

(Nicotiana
tabacum) 		PF04043
(PMEI) 		4 LEU B  22
ILE B  38
VAL B 138
THR B  11
 None
 0.80A 4ma7A-2xqrB:
undetectable		 4ma7A-2xqrB:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xqy ENVELOPE
GLYCOPROTEIN H

(Suid
alphaherpesvirus
1) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		4 VAL A 631
LEU A 622
TYR A 578
ILE A 584
 None
 0.71A 4ma7A-2xqyA:
undetectable		 4ma7A-2xqyA:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y4l MANNOSYLGLYCERATE
SYNTHASE

(Rhodothermus
marinus) 		no annotation 4 LEU A  84
ILE A 191
VAL A 198
THR A 199
 None
 0.94A 4ma7A-2y4lA:
undetectable		 4ma7A-2y4lA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE

(Streptococcus
pneumoniae) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48)
PF03714
(PUD) 		4 VAL A1103
LEU A1138
ILE A1049
THR A1124
 None
 0.83A 4ma7A-2ya1A:
undetectable		 4ma7A-2ya1A:
7.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE

(Streptococcus
pneumoniae) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 VAL A 648
LEU A 683
ILE A 594
THR A 669
 None
 0.89A 4ma7A-2ya2A:
undetectable		 4ma7A-2ya2A:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuf ARGINYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		4 LEU A 193
ILE A 203
VAL A 255
THR A 256
 None
 0.57A 4ma7A-2zufA:
undetectable		 4ma7A-2zufA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai5 YEAST ENHANCED GREEN
FLUORESCENT
PROTEIN,UBIQUITIN

(Aequorea
victoria;
Mus musculus) 		PF00240
(ubiquitin)
PF01353
(GFP) 		4 VAL A  55
LEU A  53
ILE A  47
VAL A  16
 None
 0.97A 4ma7A-3ai5A:
undetectable		 4ma7A-3ai5A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3at6 ALPHAA-GLOBIN
BETA-GLOBIN

(Podocnemis
unifilis) 		PF00042
(Globin) 		4 VAL A  96
LEU A 100
GLN B 131
VAL B 134
 None
 0.86A 4ma7A-3at6A:
2.5		 4ma7A-3at6A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bb8 CDP-4-KETO-6-DEOXY-D
-GLUCOSE-3-DEHYDRASE

(Yersinia
pseudotuberculosis) 		PF01041
(DegT_DnrJ_EryC1) 		4 VAL A 177
LEU A 188
ILE A 211
THR A 123
 None
None
None
PLP  A 500 (-4.6A)
 0.78A 4ma7A-3bb8A:
undetectable		 4ma7A-3bb8A:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3be7 ZN-DEPENDENT
ARGININE
CARBOXYPEPTIDASE

(unidentified) 		PF01979
(Amidohydro_1) 		4 LEU A 262
ILE A 266
GLN A 296
VAL A 292
 None
 0.93A 4ma7A-3be7A:
undetectable		 4ma7A-3be7A:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cav 3-OXO-5-BETA-STEROID
4-DEHYDROGENASE

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		5 VAL A 108
LEU A 109
TYR A  84
ILE A  82
THR A  25
 None
 1.37A 4ma7A-3cavA:
undetectable		 4ma7A-3cavA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3crd RAIDD

(Homo sapiens) 		PF00619
(CARD) 		4 VAL A   8
LEU A   9
ILE A  60
VAL A  26
 None
 0.93A 4ma7A-3crdA:
undetectable		 4ma7A-3crdA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddr HASR PROTEIN

(Serratia
marcescens) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 VAL A 153
ILE A 354
VAL A 379
THR A 350
 None
 0.94A 4ma7A-3ddrA:
undetectable		 4ma7A-3ddrA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		4 VAL A  72
LEU A  86
TYR A  87
VAL A  37
 None
 0.93A 4ma7A-3dxnA:
undetectable		 4ma7A-3dxnA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1s EXODEOXYRIBONUCLEASE
V, SUBUNIT RECD

(Deinococcus
radiodurans) 		PF13538
(UvrD_C_2)
PF13604
(AAA_30)
PF14490
(HHH_4) 		4 LEU A 709
ILE A 312
VAL A 357
THR A 485
 None
 0.84A 4ma7A-3e1sA:
undetectable		 4ma7A-3e1sA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eof PUTATIVE
OXIDOREDUCTASE

(Bacteroides
fragilis) 		PF00881
(Nitroreductase) 		4 LEU A  27
ILE A 127
VAL A   5
THR A   4
 None
 0.91A 4ma7A-3eofA:
undetectable		 4ma7A-3eofA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ep7 S-ADENOSYLMETHIONINE
DECARBOXYLASE ALPHA
CHAIN

(Homo sapiens) 		PF01536
(SAM_decarbox) 		4 VAL A 286
LEU A 284
ILE A 268
GLN A 300
 None
 0.86A 4ma7A-3ep7A:
undetectable		 4ma7A-3ep7A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ep7 S-ADENOSYLMETHIONINE
DECARBOXYLASE ALPHA
CHAIN

(Homo sapiens) 		PF01536
(SAM_decarbox) 		4 VAL A 286
LEU A 284
TYR A 264
ILE A 268
 None
 0.92A 4ma7A-3ep7A:
undetectable		 4ma7A-3ep7A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eza PHOSPHOTRANSFERASE
SYSTEM, ENZYME I

(Escherichia
coli) 		PF00391
(PEP-utilizers)
PF05524
(PEP-utilisers_N) 		4 LEU A 197
ILE A 192
VAL A 203
THR A 181
 None
 0.92A 4ma7A-3ezaA:
undetectable		 4ma7A-3ezaA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f7m ALKALINE SERINE
PROTEASE VER112

(Lecanicillium
psalliotae) 		PF00082
(Peptidase_S8) 		4 VAL A 257
LEU A 252
ILE A 212
VAL A 199
 None
 0.97A 4ma7A-3f7mA:
undetectable		 4ma7A-3f7mA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fds DNA POLYMERASE
SLIDING CLAMP C

(Sulfolobus
solfataricus) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 LEU D 231
TYR D 236
VAL D  19
THR D  18
 None
 0.95A 4ma7A-3fdsD:
undetectable		 4ma7A-3fdsD:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fw6 CELLULASE

(uncultured
bacterium) 		PF12891
(Glyco_hydro_44) 		4 TYR A 249
ILE A 128
GLN A 194
VAL A 134
 None
 0.89A 4ma7A-3fw6A:
undetectable		 4ma7A-3fw6A:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fyn INTEGRON GENE
CASSETTE PROTEIN
HFX_CASS3

(uncultured
bacterium) 		PF00583
(Acetyltransf_1) 		4 VAL A  62
ILE A  52
VAL A 104
THR A 103
 None
 0.66A 4ma7A-3fynA:
undetectable		 4ma7A-3fynA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5w MULTICOPPER OXIDASE
TYPE 1

(Nitrosomonas
europaea) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 VAL A 166
LEU A 164
ILE A 101
THR A 111
 None
 0.97A 4ma7A-3g5wA:
undetectable		 4ma7A-3g5wA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdj HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA

(Camelus
dromedarius) 		PF00042
(Globin) 		4 VAL A  96
LEU A 100
GLN B 131
VAL B 134
 None
 0.77A 4ma7A-3gdjA:
3.0		 4ma7A-3gdjA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gf7 GLUTACONYL-COA
DECARBOXYLASE
SUBUNIT A

([Clostridium]
symbiosum) 		PF01039
(Carboxyl_trans) 		4 TYR A 440
ILE A 439
VAL A 401
THR A 402
 None
 0.87A 4ma7A-3gf7A:
undetectable		 4ma7A-3gf7A:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdx SUSD SUPERFAMILY
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 VAL A 148
TYR A 143
VAL A 130
THR A 129
 None
 0.78A 4ma7A-3hdxA:
undetectable		 4ma7A-3hdxA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Leishmania
mexicana) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		4 VAL B 417
LEU B  18
TYR B 461
VAL B 443
 None
 0.97A 4ma7A-3igzB:
undetectable		 4ma7A-3igzB:
13.51