SIMILAR PATTERNS OF AMINO ACIDS FOR 4MA3_L_ACTL301_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bt2 PROTEIN (CATECHOL
OXIDASE)

(Ipomoea batatas) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		3 PRO A 337
ASN A 144
HIS A  53
 None
 0.91A 4ma3H-1bt2A:
0.0
4ma3L-1bt2A:
0.0		 4ma3H-1bt2A:
18.23
4ma3L-1bt2A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cc1 HYDROGENASE (LARGE
SUBUNIT)

(Desulfomicrobium
baculatum) 		PF00374
(NiFeSe_Hases) 		3 PRO L  74
ASN L 108
HIS L 176
 None
H2S  L 502 (-4.0A)
None
 1.00A 4ma3H-1cc1L:
0.0
4ma3L-1cc1L:
0.0		 4ma3H-1cc1L:
15.86
4ma3L-1cc1L:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1edg ENDOGLUCANASE A

([Clostridium]
cellulolyticum) 		PF00150
(Cellulase) 		3 PRO A  81
ASN A 169
HIS A 254
 None
 1.01A 4ma3H-1edgA:
0.0
4ma3L-1edgA:
undetectable		 4ma3H-1edgA:
18.42
4ma3L-1edgA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1miu BREAST CANCER TYPE 2
SUSCEPTIBILITY
PROTEIN

(Mus musculus) 		PF09103
(BRCA-2_OB1)
PF09104
(BRCA-2_OB3)
PF09121
(Tower)
PF09169
(BRCA-2_helical) 		3 PRO A2688
ASN A2543
HIS A2544
 None
 0.97A 4ma3H-1miuA:
0.1
4ma3L-1miuA:
undetectable		 4ma3H-1miuA:
15.51
4ma3L-1miuA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szn ALPHA-GALACTOSIDASE

(Trichoderma
reesei) 		PF16499
(Melibiase_2) 		3 PRO A 229
ASN A  20
HIS A  23
 None
 0.96A 4ma3H-1sznA:
0.0
4ma3L-1sznA:
0.0		 4ma3H-1sznA:
21.28
4ma3L-1sznA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1td2 PYRIDOXAMINE KINASE

(Escherichia
coli) 		PF08543
(Phos_pyr_kin) 		3 PRO A  35
ASN A  37
HIS A  11
 None
 0.94A 4ma3H-1td2A:
undetectable
4ma3L-1td2A:
undetectable		 4ma3H-1td2A:
21.29
4ma3L-1td2A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ur4 GALACTANASE

(Bacillus
licheniformis) 		PF07745
(Glyco_hydro_53) 		3 PRO A 118
ASN A 205
HIS A 238
 None
 1.01A 4ma3H-1ur4A:
0.0
4ma3L-1ur4A:
undetectable		 4ma3H-1ur4A:
21.27
4ma3L-1ur4A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ytm PHOSPHOENOLPYRUVATE
CARBOXYKINASE [ATP]

(Anaerobiospirillum
succiniciproducens) 		PF01293
(PEPCK_ATP) 		3 PRO A 148
ASN A  21
HIS A  20
 None
 1.01A 4ma3H-1ytmA:
0.0
4ma3L-1ytmA:
undetectable		 4ma3H-1ytmA:
17.63
4ma3L-1ytmA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zuj HYPOTHETICAL PROTEIN
LLACC01001955

(Lactococcus
lactis) 		no annotation 3 PRO A  87
ASN A  96
HIS A  22
 None
 1.03A 4ma3H-1zujA:
undetectable
4ma3L-1zujA:
undetectable		 4ma3H-1zujA:
21.74
4ma3L-1zujA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5d ALPHA-AMYLASE

(Thermotoga
maritima) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		3 PRO X 516
ASN X 169
HIS X 173
 None
 0.90A 4ma3H-2b5dX:
0.0
4ma3L-2b5dX:
0.0		 4ma3H-2b5dX:
16.38
4ma3L-2b5dX:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e9w MAST/STEM CELL
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF00047
(ig) 		3 PRO A  61
ASN A  99
HIS A 101
 None
 0.86A 4ma3H-2e9wA:
9.6
4ma3L-2e9wA:
9.3		 4ma3H-2e9wA:
18.33
4ma3L-2e9wA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ecf DIPEPTIDYL PEPTIDASE
IV

(Stenotrophomonas
maltophilia) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 PRO A 450
ASN A 468
HIS A 475
 None
 1.00A 4ma3H-2ecfA:
undetectable
4ma3L-2ecfA:
undetectable		 4ma3H-2ecfA:
15.50
4ma3L-2ecfA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3a N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE

(Mycobacterium
tuberculosis) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 PRO A 340
ASN A 334
HIS A  32
 BTB  A1400 (-4.3A)
None
BTB  A1400 (-4.6A)
 1.03A 4ma3H-2i3aA:
undetectable
4ma3L-2i3aA:
1.5		 4ma3H-2i3aA:
19.09
4ma3L-2i3aA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6e HYPOTHETICAL PROTEIN

(Deinococcus
radiodurans) 		PF02621
(VitK2_biosynth) 		3 PRO A  89
ASN A 258
HIS A 254
 None
None
SO4  A 701 (-3.8A)
 0.98A 4ma3H-2i6eA:
undetectable
4ma3L-2i6eA:
undetectable		 4ma3H-2i6eA:
22.52
4ma3L-2i6eA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0w LYSINE-SENSITIVE
ASPARTOKINASE 3

(Escherichia
coli) 		PF00696
(AA_kinase)
PF01842
(ACT) 		3 PRO A 296
ASN A 394
HIS A 425
 None
 1.03A 4ma3H-2j0wA:
undetectable
4ma3L-2j0wA:
undetectable		 4ma3H-2j0wA:
19.43
4ma3L-2j0wA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jep XYLOGLUCANASE

(Paenibacillus
pabuli) 		PF00150
(Cellulase) 		3 PRO A  89
ASN A 181
HIS A 264
 None
 1.03A 4ma3H-2jepA:
undetectable
4ma3L-2jepA:
undetectable		 4ma3H-2jepA:
21.47
4ma3L-2jepA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l0b E3 UBIQUITIN-PROTEIN
LIGASE PRAJA-1

(Homo sapiens) 		PF13639
(zf-RING_2) 		3 PRO A  90
ASN A  14
HIS A  10
 None
 0.95A 4ma3H-2l0bA:
undetectable
4ma3L-2l0bA:
undetectable		 4ma3H-2l0bA:
14.81
4ma3L-2l0bA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okx RHAMNOSIDASE B

(Bacillus sp.
GL1) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		3 PRO A 627
ASN A 628
HIS A 697
 None
 0.97A 4ma3H-2okxA:
2.9
4ma3L-2okxA:
2.1		 4ma3H-2okxA:
12.82
4ma3L-2okxA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkm SPBC3B9.21 PROTEIN

(Schizosaccharomyces
pombe) 		PF06058
(DCP1) 		3 PRO A  74
ASN A  76
HIS A  19
 None
 0.82A 4ma3H-2qkmA:
undetectable
4ma3L-2qkmA:
undetectable		 4ma3H-2qkmA:
17.94
4ma3L-2qkmA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr4 PEPTIDASE M3B,
OLIGOENDOPEPTIDASE F

(Enterococcus
faecium) 		PF01432
(Peptidase_M3)
PF08439
(Peptidase_M3_N) 		3 PRO A 516
ASN A 179
HIS A 200
 None
 0.95A 4ma3H-2qr4A:
undetectable
4ma3L-2qr4A:
undetectable		 4ma3H-2qr4A:
16.41
4ma3L-2qr4A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r17 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 35

(Homo sapiens) 		PF03635
(Vps35) 		3 PRO C 755
ASN C 767
HIS C 771
 None
 1.03A 4ma3H-2r17C:
undetectable
4ma3L-2r17C:
undetectable		 4ma3H-2r17C:
19.80
4ma3L-2r17C:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2raf PUTATIVE
DINUCLEOTIDE-BINDING
OXIDOREDUCTASE

(Lactobacillus
plantarum) 		PF03807
(F420_oxidored) 		3 PRO A 149
ASN A  18
HIS A  17
 None
 0.99A 4ma3H-2rafA:
undetectable
4ma3L-2rafA:
undetectable		 4ma3H-2rafA:
17.35
4ma3L-2rafA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjq ADAMTS-5

(Homo sapiens) 		PF01421
(Reprolysin) 		3 PRO A 390
ASN A 349
HIS A 358
 None
 0.64A 4ma3H-2rjqA:
undetectable
4ma3L-2rjqA:
undetectable		 4ma3H-2rjqA:
23.10
4ma3L-2rjqA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vat ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE

(Acremonium
chrysogenum) 		PF00561
(Abhydrolase_1) 		3 PRO A  95
ASN A  90
HIS A  57
 None
 1.01A 4ma3H-2vatA:
undetectable
4ma3L-2vatA:
undetectable		 4ma3H-2vatA:
19.87
4ma3L-2vatA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdt LEVANSUCRASE

(Bacillus
subtilis) 		PF02435
(Glyco_hydro_68) 		3 PRO A 417
ASN A 345
HIS A 249
 None
 0.82A 4ma3H-2vdtA:
undetectable
4ma3L-2vdtA:
undetectable		 4ma3H-2vdtA:
21.28
4ma3L-2vdtA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yew E1 ENVELOPE
GLYCOPROTEIN
E2 ENVELOPE
GLYCOPROTEIN

(Barmah Forest
virus;
Barmah Forest
virus) 		PF01589
(Alpha_E1_glycop)
PF00943
(Alpha_E2_glycop) 		3 PRO B  56
ASN C 237
HIS C 167
 None
 0.98A 4ma3H-2yewB:
undetectable
4ma3L-2yewB:
3.4		 4ma3H-2yewB:
21.08
4ma3L-2yewB:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywg GTP-BINDING PROTEIN
LEPA

(Aquifex
aeolicus) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF06421
(LepA_C) 		3 PRO A 185
ASN A   8
HIS A  76
 None
 0.92A 4ma3H-2ywgA:
2.4
4ma3L-2ywgA:
2.4		 4ma3H-2ywgA:
14.81
4ma3L-2ywgA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0f PUTATIVE
PHOSPHOGLUCOMUTASE

(Thermus
thermophilus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		3 PRO A 471
ASN A 468
HIS A 355
 None
 1.03A 4ma3H-2z0fA:
undetectable
4ma3L-2z0fA:
undetectable		 4ma3H-2z0fA:
16.31
4ma3L-2z0fA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zj4 GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING] 1

(Homo sapiens) 		PF01380
(SIS) 		3 PRO A 467
ASN A 447
HIS A 462
 None
 0.84A 4ma3H-2zj4A:
undetectable
4ma3L-2zj4A:
undetectable		 4ma3H-2zj4A:
19.23
4ma3L-2zj4A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9x SELENOCYSTEINE LYASE

(Rattus
norvegicus) 		PF00266
(Aminotran_5) 		3 PRO A 393
ASN A 333
HIS A 331
 None
 0.93A 4ma3H-3a9xA:
undetectable
4ma3L-3a9xA:
undetectable		 4ma3H-3a9xA:
19.40
4ma3L-3a9xA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ada SARCOSINE OXIDASE
BETA SUBUNIT

(Corynebacterium
sp. U-96) 		PF01266
(DAO) 		3 PRO B 336
ASN B 349
HIS B  31
 None
None
FAD  B   1 (-3.8A)
 0.83A 4ma3H-3adaB:
undetectable
4ma3L-3adaB:
undetectable		 4ma3H-3adaB:
17.11
4ma3L-3adaB:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 PRO A 141
ASN A 138
HIS A 127
 None
 0.78A 4ma3H-3e9yA:
undetectable
4ma3L-3e9yA:
undetectable		 4ma3H-3e9yA:
17.70
4ma3L-3e9yA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fk2 GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1

(Homo sapiens) 		PF00620
(RhoGAP) 		3 PRO A1433
ASN A1380
HIS A1384
 None
 0.55A 4ma3H-3fk2A:
undetectable
4ma3L-3fk2A:
undetectable		 4ma3H-3fk2A:
20.73
4ma3L-3fk2A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gi8 UNCHARACTERIZED
PROTEIN MJ0609

(Methanocaldococcus
jannaschii) 		PF13520
(AA_permease_2) 		3 PRO C 309
ASN C  69
HIS C 213
 None
 1.00A 4ma3H-3gi8C:
undetectable
4ma3L-3gi8C:
undetectable		 4ma3H-3gi8C:
19.73
4ma3L-3gi8C:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyr PHENOXAZINONE
SYNTHASE

(Streptomyces
antibioticus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 PRO A 521
ASN A 518
HIS A 524
 None
None
CU  A1000 (-3.0A)
 1.00A 4ma3H-3gyrA:
undetectable
4ma3L-3gyrA:
2.0		 4ma3H-3gyrA:
16.20
4ma3L-3gyrA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hfw PROTEIN
ADP-RIBOSYLARGININE
HYDROLASE

(Homo sapiens) 		PF03747
(ADP_ribosyl_GH) 		3 PRO A 121
ASN A 106
HIS A 105
 None
 0.88A 4ma3H-3hfwA:
undetectable
4ma3L-3hfwA:
undetectable		 4ma3H-3hfwA:
18.75
4ma3L-3hfwA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kdq UNCHARACTERIZED
CONSERVED PROTEIN

(Corynebacterium
diphtheriae) 		no annotation 3 PRO A  36
ASN A  39
HIS A  41
 None
 1.03A 4ma3H-3kdqA:
undetectable
4ma3L-3kdqA:
undetectable		 4ma3H-3kdqA:
19.21
4ma3L-3kdqA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6v DNA GYRASE SUBUNIT A

(Xanthomonas
campestris) 		PF03989
(DNA_gyraseA_C) 		3 PRO A 535
ASN A 584
HIS A 586
 None
 1.01A 4ma3H-3l6vA:
undetectable
4ma3L-3l6vA:
undetectable		 4ma3H-3l6vA:
24.07
4ma3L-3l6vA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m33 UNCHARACTERIZED
PROTEIN

(Deinococcus
radiodurans) 		no annotation 3 PRO A 148
ASN A 143
HIS A 163
 None
 1.00A 4ma3H-3m33A:
undetectable
4ma3L-3m33A:
undetectable		 4ma3H-3m33A:
21.29
4ma3L-3m33A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL

(Homo sapiens) 		PF00067
(p450) 		3 PRO A  54
ASN A  81
HIS A  77
 None
 0.73A 4ma3H-3na0A:
undetectable
4ma3L-3na0A:
undetectable		 4ma3H-3na0A:
16.77
4ma3L-3na0A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3om5 LEVANSUCRASE

(Bacillus
megaterium) 		PF02435
(Glyco_hydro_68) 		3 PRO A 427
ASN A 355
HIS A 259
 None
 0.66A 4ma3H-3om5A:
undetectable
4ma3L-3om5A:
undetectable		 4ma3H-3om5A:
19.30
4ma3L-3om5A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p1v METALLO-ENDOPEPTIDAS
E

(Bacteroides
ovatus) 		PF09471
(Peptidase_M64)
PF16217
(M64_N) 		3 PRO A  68
ASN A 293
HIS A 276
 None
 1.03A 4ma3H-3p1vA:
3.7
4ma3L-3p1vA:
2.4		 4ma3H-3p1vA:
18.67
4ma3L-3p1vA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pg1 MITOGEN-ACTIVATED
PROTEIN KINASE,
PUTATIVE (MAP
KINASE-LIKE PROTEIN)

(Leishmania
major) 		PF00069
(Pkinase) 		3 PRO A  88
ASN A  89
HIS A 141
 None
 1.02A 4ma3H-3pg1A:
undetectable
4ma3L-3pg1A:
undetectable		 4ma3H-3pg1A:
18.63
4ma3L-3pg1A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pzs PYRIDOXAMINE KINASE

(Yersinia pestis) 		PF08543
(Phos_pyr_kin) 		3 PRO A  34
ASN A  36
HIS A  10
 None
 0.95A 4ma3H-3pzsA:
undetectable
4ma3L-3pzsA:
undetectable		 4ma3H-3pzsA:
21.22
4ma3L-3pzsA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q2h A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 1

(Homo sapiens) 		PF01421
(Reprolysin) 		3 PRO A 129
ASN A  88
HIS A  97
 None
 0.75A 4ma3H-3q2hA:
undetectable
4ma3L-3q2hA:
undetectable		 4ma3H-3q2hA:
21.26
4ma3L-3q2hA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qty PHOSPHORIBOSYLAMINOI
MIDAZOLE (AIR)
SYNTHETASE

(Francisella
tularensis) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		3 PRO A 281
ASN A 303
HIS A 190
 None
 0.87A 4ma3H-3qtyA:
undetectable
4ma3L-3qtyA:
undetectable		 4ma3H-3qtyA:
21.41
4ma3L-3qtyA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v39 D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Bdellovibrio
bacteriovorus) 		PF02113
(Peptidase_S13) 		3 PRO A  67
ASN A  42
HIS A 385
 None
 1.00A 4ma3H-3v39A:
undetectable
4ma3L-3v39A:
undetectable		 4ma3H-3v39A:
21.81
4ma3L-3v39A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL

(Trypanosoma
brucei) 		PF01786
(AOX) 		3 PRO A  63
ASN A 161
HIS A 165
 None
None
FE  A 501 (-3.3A)
 0.90A 4ma3H-3vvaA:
undetectable
4ma3L-3vvaA:
undetectable		 4ma3H-3vvaA:
22.32
4ma3L-3vvaA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxb UNCHARACTERIZED
PROTEIN

(Gallus gallus) 		PF00106
(adh_short) 		3 PRO A  32
ASN A  60
HIS A  58
 None
 0.91A 4ma3H-3wxbA:
undetectable
4ma3L-3wxbA:
undetectable		 4ma3H-3wxbA:
23.49
4ma3L-3wxbA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3

(Homo sapiens) 		PF00069
(Pkinase) 		3 PRO A 240
ASN A 219
HIS A 244
 None
 0.88A 4ma3H-3zduA:
undetectable
4ma3L-3zduA:
undetectable		 4ma3H-3zduA:
20.66
4ma3L-3zduA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING

(Desulfovibrio
vulgaris) 		PF00374
(NiFeSe_Hases) 		3 PRO B  79
ASN B 113
HIS B 173
 OCS  B  75 ( 3.1A)
H2S  B 503 (-4.1A)
None
 1.00A 4ma3H-3ze7B:
undetectable
4ma3L-3ze7B:
undetectable		 4ma3H-3ze7B:
18.59
4ma3L-3ze7B:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zlb PHOSPHOGLYCERATE
KINASE

(Streptococcus
pneumoniae) 		PF00162
(PGK) 		3 PRO A 390
ASN A 162
HIS A 159
 None
 0.86A 4ma3H-3zlbA:
undetectable
4ma3L-3zlbA:
undetectable		 4ma3H-3zlbA:
19.05
4ma3L-3zlbA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zmr CELLULASE (GLYCOSYL
HYDROLASE FAMILY 5)

(Bacteroides
ovatus) 		PF00150
(Cellulase)
PF13004
(BACON) 		3 PRO A 209
ASN A 296
HIS A 371
 None
BGC  A1518 (-2.8A)
BGC  A1518 ( 4.8A)
 1.02A 4ma3H-3zmrA:
3.6
4ma3L-3zmrA:
4.3		 4ma3H-3zmrA:
19.29
4ma3L-3zmrA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a1s PARTNER OF
INSCUTEABLE
RE60102P

(Drosophila
melanogaster;
Drosophila
melanogaster) 		PF13176
(TPR_7)
PF13424
(TPR_12)
no annotation 		3 PRO C   9
ASN A 306
HIS A 321
 None
 0.86A 4ma3H-4a1sC:
undetectable
4ma3L-4a1sC:
undetectable		 4ma3H-4a1sC:
11.76
4ma3L-4a1sC:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aui PORIN (PORB)

(Neisseria
gonorrhoeae) 		PF00267
(Porin_1) 		3 PRO A 121
ASN A  95
HIS A 159
 None
 0.90A 4ma3H-4auiA:
undetectable
4ma3L-4auiA:
undetectable		 4ma3H-4auiA:
21.82
4ma3L-4auiA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d3y LEGUMAIN

(Cricetulus
griseus) 		PF01650
(Peptidase_C13) 		3 PRO A 316
ASN A  47
HIS A 153
 None
None
SNN  A 152 ( 3.5A)
 1.03A 4ma3H-4d3yA:
undetectable
4ma3L-4d3yA:
undetectable		 4ma3H-4d3yA:
18.63
4ma3L-4d3yA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dg5 PHOSPHOGLYCERATE
KINASE

(Staphylococcus
aureus) 		PF00162
(PGK) 		3 PRO A 388
ASN A 161
HIS A 158
 None
 0.93A 4ma3H-4dg5A:
undetectable
4ma3L-4dg5A:
undetectable		 4ma3H-4dg5A:
19.55
4ma3L-4dg5A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dia 2-PYRONE-4,6-DICARBA
XYLATE HYDROLASE

(Sphingomonas
paucimobilis) 		PF04909
(Amidohydro_2) 		3 PRO A 252
ASN A 248
HIS A  31
 None
 0.84A 4ma3H-4diaA:
undetectable
4ma3L-4diaA:
undetectable		 4ma3H-4diaA:
21.12
4ma3L-4diaA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dia 2-PYRONE-4,6-DICARBA
XYLATE HYDROLASE

(Sphingomonas
paucimobilis) 		PF04909
(Amidohydro_2) 		3 PRO A 252
ASN A 248
HIS A 180
 None
 0.95A 4ma3H-4diaA:
undetectable
4ma3L-4diaA:
undetectable		 4ma3H-4diaA:
21.12
4ma3L-4diaA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1x PHOSPHATE-BINDING
PROTEIN PSTS 2

(Streptococcus
pneumoniae) 		PF12849
(PBP_like_2) 		3 PRO A 131
ASN A 133
HIS A 250
 None
 1.02A 4ma3H-4h1xA:
undetectable
4ma3L-4h1xA:
undetectable		 4ma3H-4h1xA:
24.82
4ma3L-4h1xA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hk9 ENDO-1,4-BETA-XYLANA
SE 2

(Trichoderma
reesei) 		PF00457
(Glyco_hydro_11) 		3 PRO A  68
ASN A  92
HIS A 144
 None
 0.97A 4ma3H-4hk9A:
undetectable
4ma3L-4hk9A:
undetectable		 4ma3H-4hk9A:
23.01
4ma3L-4hk9A:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifq NUCLEOPORIN NUP192

(Saccharomyces
cerevisiae) 		PF11894
(Nup192) 		3 PRO A 901
ASN A 829
HIS A 907
 None
 0.97A 4ma3H-4ifqA:
undetectable
4ma3L-4ifqA:
undetectable		 4ma3H-4ifqA:
13.05
4ma3L-4ifqA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4och ENDONUCLEASE MUTS2

(Deinococcus
radiodurans) 		PF01713
(Smr) 		3 PRO A 718
ASN A 763
HIS A 748
 None
 0.89A 4ma3H-4ochA:
undetectable
4ma3L-4ochA:
undetectable		 4ma3H-4ochA:
17.48
4ma3L-4ochA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oj2 AQUAPORIN-2

(Homo sapiens) 		PF00230
(MIP) 		3 PRO X 225
ASN X 220
HIS X  80
 None
 0.94A 4ma3H-4oj2X:
undetectable
4ma3L-4oj2X:
undetectable		 4ma3H-4oj2X:
25.84
4ma3L-4oj2X:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4owr MRNA EXPORT FACTOR

(Homo sapiens) 		PF00400
(WD40) 		3 PRO A 250
ASN A 254
HIS A 243
 None
 0.93A 4ma3H-4owrA:
undetectable
4ma3L-4owrA:
undetectable		 4ma3H-4owrA:
20.23
4ma3L-4owrA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qax 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Staphylococcus
aureus) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		3 PRO A  55
ASN A  83
HIS A 128
 None
 1.03A 4ma3H-4qaxA:
undetectable
4ma3L-4qaxA:
undetectable		 4ma3H-4qaxA:
15.53
4ma3L-4qaxA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8l UNCHARACTERIZED
PROTEIN

(Cavia porcellus) 		PF00710
(Asparaginase) 		3 PRO A 339
ASN A 233
HIS A 231
 None
 0.87A 4ma3H-4r8lA:
undetectable
4ma3L-4r8lA:
undetectable		 4ma3H-4r8lA:
20.67
4ma3L-4r8lA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ru0 PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC
BRANCHED-CHAIN AMINO
ACID-BINDING PROTEIN

(Pseudomonas
protegens) 		PF13458
(Peripla_BP_6) 		3 PRO A 290
ASN A 325
HIS A 298
 None
 1.03A 4ma3H-4ru0A:
undetectable
4ma3L-4ru0A:
undetectable		 4ma3H-4ru0A:
19.15
4ma3L-4ru0A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2x ENDO-BETA-1,4-GLUCAN
ASE (CELLULASE B)

(Bacillus
halodurans) 		PF00150
(Cellulase)
PF03442
(CBM_X2) 		3 PRO A 227
ASN A 231
HIS A 189
 None
 0.94A 4ma3H-4v2xA:
4.8
4ma3L-4v2xA:
5.9		 4ma3H-4v2xA:
16.08
4ma3L-4v2xA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z42 UREASE SUBUNIT ALPHA

(Yersinia
enterocolitica) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		3 PRO C 105
ASN C  58
HIS C  60
 None
 0.98A 4ma3H-4z42C:
undetectable
4ma3L-4z42C:
undetectable		 4ma3H-4z42C:
16.90
4ma3L-4z42C:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a42 UNCHARACTERIZED
LIPOPROTEIN YFHM

(Escherichia
coli) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF11974
(MG1) 		3 PRO A 393
ASN A 406
HIS A 447
 None
 0.74A 4ma3H-5a42A:
6.2
4ma3L-5a42A:
undetectable		 4ma3H-5a42A:
8.88
4ma3L-5a42A:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7d PINS
INSCUTEABLE

(Drosophila
melanogaster;
Drosophila
melanogaster) 		PF13176
(TPR_7)
PF13424
(TPR_12)
no annotation 		3 PRO L 309
ASN B 306
HIS B 321
 None
 0.89A 4ma3H-5a7dL:
undetectable
4ma3L-5a7dL:
undetectable		 4ma3H-5a7dL:
19.50
4ma3L-5a7dL:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aee ALPHA-GLUCOSIDASE
YIHQ

(Escherichia
coli) 		PF01055
(Glyco_hydro_31) 		3 PRO A 183
ASN A 427
HIS A 426
 None
 0.91A 4ma3H-5aeeA:
undetectable
4ma3L-5aeeA:
1.3		 4ma3H-5aeeA:
16.62
4ma3L-5aeeA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5avm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Thermus
thermophilus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		3 PRO A 273
ASN A 295
HIS A 186
 None
 0.87A 4ma3H-5avmA:
undetectable
4ma3L-5avmA:
undetectable		 4ma3H-5avmA:
21.36
4ma3L-5avmA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b6a PYRIDOXAL KINASE
PDXY

(Pseudomonas
aeruginosa) 		PF08543
(Phos_pyr_kin) 		3 PRO A  37
ASN A  39
HIS A  13
 None
 0.93A 4ma3H-5b6aA:
undetectable
4ma3L-5b6aA:
undetectable		 4ma3H-5b6aA:
23.51
4ma3L-5b6aA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c41 RIBOKINASE

(Homo sapiens) 		PF00294
(PfkB) 		3 PRO A 255
ASN A 292
HIS A 328
 None
 0.66A 4ma3H-5c41A:
undetectable
4ma3L-5c41A:
undetectable		 4ma3H-5c41A:
23.46
4ma3L-5c41A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9n B-1,4-ENDOGLUCANASE

(Prevotella
bryantii) 		PF00150
(Cellulase) 		3 PRO A  72
ASN A 161
HIS A 238
 None
 1.03A 4ma3H-5d9nA:
undetectable
4ma3L-5d9nA:
undetectable		 4ma3H-5d9nA:
19.66
4ma3L-5d9nA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dne L-ASPARAGINASE

(Cavia porcellus) 		PF00710
(Asparaginase) 		3 PRO A 339
ASN A 233
HIS A 231
 None
 0.86A 4ma3H-5dneA:
undetectable
4ma3L-5dneA:
undetectable		 4ma3H-5dneA:
16.78
4ma3L-5dneA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e05 NUCLEOCAPSID PROTEIN

(Sin Nombre
orthohantavirus) 		PF00846
(Hanta_nucleocap) 		3 PRO A 245
ASN A 261
HIS A 386
 None
 0.97A 4ma3H-5e05A:
undetectable
4ma3L-5e05A:
undetectable		 4ma3H-5e05A:
22.56
4ma3L-5e05A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eio N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE/N-ACET
YL-GAMMA-AMINOADIPYL
-PHOSPHATE REDUCTASE

(Thermus
thermophilus) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 PRO A 332
ASN A 326
HIS A  26
 None
 1.00A 4ma3H-5eioA:
0.9
4ma3L-5eioA:
undetectable		 4ma3H-5eioA:
19.54
4ma3L-5eioA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5flv HOMEOBOX PROTEIN
NKX-2.5, T-BOX
TRANSCRIPTION FACTOR
TBX5

(Mus musculus) 		PF00046
(Homeobox)
PF00907
(T-box) 		3 PRO A1129
ASN A1174
HIS A1164
 None
 0.91A 4ma3H-5flvA:
undetectable
4ma3L-5flvA:
2.0		 4ma3H-5flvA:
21.57
4ma3L-5flvA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5haf DEUBIQUITINASE SSEL

(Salmonella
enterica) 		no annotation 3 PRO A 304
ASN A 213
HIS A 212
 None
 0.79A 4ma3H-5hafA:
undetectable
4ma3L-5hafA:
undetectable		 4ma3H-5hafA:
17.75
4ma3L-5hafA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B

(Homo sapiens) 		no annotation 3 PRO A 661
ASN A 500
HIS A 504
 None
 0.66A 4ma3H-5hdtA:
undetectable
4ma3L-5hdtA:
undetectable		 4ma3H-5hdtA:
10.82
4ma3L-5hdtA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i0c UNCHARACTERIZED
PROTEIN YJDJ

(Escherichia
coli) 		PF14542
(Acetyltransf_CG) 		3 PRO A  27
ASN A   8
HIS A   7
 None
 0.83A 4ma3H-5i0cA:
undetectable
4ma3L-5i0cA:
undetectable		 4ma3H-5i0cA:
16.67
4ma3L-5i0cA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i0p BETA-LACTAMASE
DOMAIN PROTEIN

(Burkholderia
ambifaria) 		PF00753
(Lactamase_B) 		3 PRO A 267
ASN A  44
HIS A  42
 None
 0.85A 4ma3H-5i0pA:
undetectable
4ma3L-5i0pA:
undetectable		 4ma3H-5i0pA:
22.41
4ma3L-5i0pA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ibz UNCHARACTERIZED
PROTEIN

(uncultured
organism) 		PF04199
(Cyclase) 		3 PRO A 284
ASN A 288
HIS A  30
 None
 0.90A 4ma3H-5ibzA:
undetectable
4ma3L-5ibzA:
undetectable		 4ma3H-5ibzA:
20.95
4ma3L-5ibzA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5irc RHO
GTPASE-ACTIVATING
PROTEIN 35

(Rattus
norvegicus) 		PF00620
(RhoGAP) 		3 PRO A1433
ASN A1380
HIS A1384
 CSX  A1432 ( 2.6A)
CSX  A1432 ( 4.0A)
None
 0.56A 4ma3H-5ircA:
undetectable
4ma3L-5ircA:
undetectable		 4ma3H-5ircA:
20.83
4ma3L-5ircA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA

(Methylobacillus
flagellatus) 		PF00364
(Biotin_lipoyl)
PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		3 PRO C 339
ASN C  86
HIS C  92
 None
 0.93A 4ma3H-5ks8C:
undetectable
4ma3L-5ks8C:
undetectable		 4ma3H-5ks8C:
16.29
4ma3L-5ks8C:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE

(Homo sapiens) 		no annotation 3 PRO A 808
ASN A 815
HIS A 817
 None
 1.03A 4ma3H-5nn8A:
undetectable
4ma3L-5nn8A:
undetectable		 4ma3H-5nn8A:
14.00
4ma3L-5nn8A:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohs -

(-) 		no annotation 3 PRO A 166
ASN A 410
HIS A 409
 None
 0.96A 4ma3H-5ohsA:
2.0
4ma3L-5ohsA:
undetectable		 4ma3H-5ohsA:
undetectable
4ma3L-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tqi PYRIDOXAL KINASE
PDXY

(Burkholderia
multivorans) 		PF08543
(Phos_pyr_kin) 		3 PRO A  34
ASN A  36
HIS A  10
 None
CL  A 300 (-4.1A)
None
 0.90A 4ma3H-5tqiA:
undetectable
4ma3L-5tqiA:
undetectable		 4ma3H-5tqiA:
19.93
4ma3L-5tqiA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5trw PYRIDOXAL KINASE
PDXY

(Paraburkholderia
xenovorans) 		PF08543
(Phos_pyr_kin) 		3 PRO A  35
ASN A  37
HIS A  11
 None
 0.93A 4ma3H-5trwA:
undetectable
4ma3L-5trwA:
undetectable		 4ma3H-5trwA:
21.26
4ma3L-5trwA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vni PROTEIN TRANSPORT
PROTEIN SEC23A

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		3 PRO A 422
ASN A 365
HIS A 605
 None
 1.03A 4ma3H-5vniA:
1.1
4ma3L-5vniA:
1.6		 4ma3H-5vniA:
15.12
4ma3L-5vniA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3l VIRAL PROTEIN 3

(Rhinovirus B) 		PF00073
(Rhv) 		3 PRO B  70
ASN B  56
HIS B  59
 None
 1.00A 4ma3H-5w3lB:
undetectable
4ma3L-5w3lB:
undetectable		 4ma3H-5w3lB:
20.73
4ma3L-5w3lB:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbp 3NT OXYGENASE BETA
SUBUNIT

(Diaphorobacter
sp. DS2) 		PF00866
(Ring_hydroxyl_B) 		3 PRO C 108
ASN C 106
HIS C 100
 None
 0.73A 4ma3H-5xbpC:
undetectable
4ma3L-5xbpC:
undetectable		 4ma3H-5xbpC:
18.80
4ma3L-5xbpC:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao1 BETA-LACTAMASE
DOMAIN PROTEIN

(Paraburkholderia
phymatum) 		PF00753
(Lactamase_B) 		3 PRO A 267
ASN A  44
HIS A  42
 None
 0.88A 4ma3H-6ao1A:
undetectable
4ma3L-6ao1A:
undetectable		 4ma3H-6ao1A:
18.75
4ma3L-6ao1A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cg0 V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 2

(Mus musculus) 		no annotation 3 PRO D  59
ASN D  11
HIS D  10
 None
 0.96A 4ma3H-6cg0D:
undetectable
4ma3L-6cg0D:
undetectable		 4ma3H-6cg0D:
undetectable
4ma3L-6cg0D:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cim V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 2

(Mus musculus) 		no annotation 3 PRO B  59
ASN B  11
HIS B  10
 None
 0.89A 4ma3H-6cimB:
undetectable
4ma3L-6cimB:
undetectable		 4ma3H-6cimB:
undetectable
4ma3L-6cimB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2

(Saccharomyces
cerevisiae) 		no annotation 3 PRO A1362
ASN A1394
HIS A1393
 None
 1.03A 4ma3H-6emkA:
undetectable
4ma3L-6emkA:
undetectable		 4ma3H-6emkA:
undetectable
4ma3L-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evg MULTI-COPPER OXIDASE
CUEO

(Ochrobactrum) 		no annotation 3 PRO A 433
ASN A 232
HIS A 234
 None
 1.01A 4ma3H-6evgA:
undetectable
4ma3L-6evgA:
undetectable		 4ma3H-6evgA:
undetectable
4ma3L-6evgA:
undetectable