SIMILAR PATTERNS OF AMINO ACIDS FOR 4M93_B_ACTB305_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1etz FAB NC10.14 - HEAVY
CHAIN

(Mus musculus) 		no annotation 4 SER H  19
THR H  21
PHE H  81
LYS H  83
 None
 0.47A 4m93B-1etzH:
23.0		 4m93B-1etzH:
65.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1p4i ANTIBODY VARIABLE
HEAVY CHAIN

(Mus musculus) 		PF07686
(V-set) 		4 SER H  20
THR H  22
PHE H  90
LYS H  92
 None
 0.26A 4m93B-1p4iH:
20.0		 4m93B-1p4iH:
42.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vgm 378AA LONG
HYPOTHETICAL CITRATE
SYNTHASE

(Sulfurisphaera
tokodaii) 		PF00285
(Citrate_synt) 		4 SER A 306
THR A 303
PHE A 304
LYS A 307
 None
 1.47A 4m93B-1vgmA:
undetectable		 4m93B-1vgmA:
19.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zan FAB AD11 HEAVY CHAIN

(Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 SER H  19
THR H  21
PHE H  79
LYS H  81
 None
 0.26A 4m93B-1zanH:
25.1		 4m93B-1zanH:
77.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gjz CATALYTIC
ELIMINATION ANTIBODY
13G5 HEAVY CHAIN

(Mus musculus) 		no annotation 4 SER H  19
THR H  21
PHE H  79
LYS H  81
 None
 0.90A 4m93B-2gjzH:
24.6		 4m93B-2gjzH:
78.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vq1 ANTI-HUMAN FC GAMMA
RECEPTOR III 3G8
GAMMA HEAVY CHAIN
VARIABLE REGION

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 SER B  19
THR B  21
PHE B  79
LYS B  81
 None
 0.81A 4m93B-2vq1B:
21.4		 4m93B-2vq1B:
61.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b9k FAB HEAVY CHAIN

(Rattus rattus) 		no annotation 4 SER H  19
THR H  21
PHE H  79
LYS H  81
 None
 0.41A 4m93B-3b9kH:
25.0		 4m93B-3b9kH:
73.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ifl 12A11 FAB ANTIBODY
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 SER H  19
THR H  21
PHE H  81
LYS H  83
 None
 0.53A 4m93B-3iflH:
25.3		 4m93B-3iflH:
77.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
43ca PROTEIN
(IMMUNOGLOBULIN
(HEAVY CHAIN))

(Mus musculus) 		PF07686
(V-set) 		4 SER B  19
THR B  21
PHE B  79
LYS B  81
 None
 0.64A 4m93B-43caB:
20.2		 4m93B-43caB:
74.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4edx HEAVY CHAIN OF FAB
OF MURINE ANTI-NGF

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 SER B  19
THR B  21
PHE B  79
LYS B  81
 None
 0.61A 4m93B-4edxB:
22.5		 4m93B-4edxB:
77.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ij3 HEAVY CHAIN OF FAB
FRAGMENT

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 SER C  19
THR C  21
PHE C  79
LYS C  81
 None
 0.38A 4m93B-4ij3C:
26.3		 4m93B-4ij3C:
86.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yzf FAB FRAGMENT OF
IMMUNOGLOBULIN (IGG)
MOLECULE

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 SER E  19
THR E  21
PHE E  81
LYS E  83
 None
 0.81A 4m93B-4yzfE:
24.7		 4m93B-4yzfE:
70.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hbt FAB35, HEAVY CHAIN

(Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 SER D  19
THR D  21
PHE D  79
LYS D  81
 None
 0.84A 4m93B-5hbtD:
21.5		 4m93B-5hbtD:
71.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5kov PL-2 SCFV CHAIN

(Mus musculus) 		PF07686
(V-set) 		4 SER C  19
THR C  21
PHE C  79
LYS C  81
 None
 0.72A 4m93B-5kovC:
14.1		 4m93B-5kovC:
50.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0m TERMINAL
URIDYLYLTRANSFERASE
7

(Homo sapiens) 		PF00098
(zf-CCHC)
PF03828
(PAP_assoc) 		4 SER A1170
THR A1174
PHE A1052
LYS A1152
 SO4  A1401 (-2.8A)
IOD  A1404 (-3.7A)
None
SO4  A1401 ( 2.7A)
 1.32A 4m93B-5w0mA:
undetectable		 4m93B-5w0mA:
19.75