SIMILAR PATTERNS OF AMINO ACIDS FOR 4M93_B_ACTB304_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nql ISOMERASE/LACTONIZIN
G ENZYME

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLY A  71
SER A  52
ARG A  51
PRO A  75
 None
 1.16A 4m93B-2nqlA:
undetectable
4m93C-2nqlA:
0.0		 4m93B-2nqlA:
20.26
4m93C-2nqlA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppg PUTATIVE ISOMERASE

(Sinorhizobium
meliloti) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLY A  71
SER A  52
ARG A  51
PRO A  75
 None
 1.14A 4m93B-2ppgA:
0.0
4m93C-2ppgA:
0.0		 4m93B-2ppgA:
20.00
4m93C-2ppgA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica) 		PF03063
(Prismane) 		4 GLY A 599
SER A 597
ARG A 194
PRO A 572
 None
 1.41A 4m93B-3i04A:
0.0
4m93C-3i04A:
undetectable		 4m93B-3i04A:
16.10
4m93C-3i04A:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8c RIBOSE 5-PHOSPHATE
ISOMERASE

(Trypanosoma
cruzi) 		PF02502
(LacAB_rpiB) 		4 GLY A  70
SER A  71
ARG A 113
PRO A  12
 RES  A 160 (-3.3A)
RES  A 160 (-3.2A)
RES  A 160 (-3.1A)
RES  A 160 ( 4.7A)
 1.09A 4m93B-3k8cA:
undetectable
4m93C-3k8cA:
0.0		 4m93B-3k8cA:
20.54
4m93C-3k8cA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1p RIBOSE 5-PHOSPHATE
ISOMERASE

(Trypanosoma
cruzi) 		PF02502
(LacAB_rpiB) 		4 GLY A  70
SER A  71
ARG A 113
PRO A  12
 None
 1.12A 4m93B-3m1pA:
0.0
4m93C-3m1pA:
undetectable		 4m93B-3m1pA:
19.05
4m93C-3m1pA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kwm HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 GLY A 224
SER A 223
ARG A 225
PRO A  92
 None
 1.30A 4m93B-4kwmA:
0.0
4m93C-4kwmA:
0.0		 4m93B-4kwmA:
20.00
4m93C-4kwmA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uoz BETA-GALACTOSIDASE

(Bifidobacterium
animalis) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		4 GLY A 313
SER A 315
ARG A 316
PRO A 463
 None
 1.17A 4m93B-4uozA:
0.0
4m93C-4uozA:
0.0		 4m93B-4uozA:
15.43
4m93C-4uozA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uy9 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLY A 329
SER A 330
ARG A 393
PRO A 390
 None
 1.43A 4m93B-4uy9A:
1.0
4m93C-4uy9A:
0.0		 4m93B-4uy9A:
20.97
4m93C-4uy9A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi RIBOSOMAL PROTEIN
S3AE, PUTATIVE

(Trichomonas
vaginalis) 		PF01015
(Ribosomal_S3Ae) 		4 GLY B  89
SER B  90
ARG B  26
PRO B  54
 None
 1.23A 4m93B-5xyiB:
0.0
4m93C-5xyiB:
0.0		 4m93B-5xyiB:
22.71
4m93C-5xyiB:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bb4 MOUSE MONOCLONAL
ANTIBODY C5.2 FAB
HEAVY CHAIN
MOUSE MONOCLONAL
ANTIBODY C5.2 FAB
LIGHT CHAIN

(Mus musculus;
Mus musculus) 		no annotation
no annotation 		4 GLY H 127
SER H 128
ARG H 213
PRO L 119
 None
 0.65A 4m93B-6bb4H:
23.5
4m93C-6bb4H:
17.5		 4m93B-6bb4H:
undetectable
4m93C-6bb4H:
undetectable