SIMILAR PATTERNS OF AMINO ACIDS FOR 4M93_B_ACTB303

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ajo CIRCULARLY PERMUTED
(1-3,1-4)-BETA-D-GLU
CAN
4-GLUCANOHYDROLASE
CPA16M-127

(Paenibacillus
macerans) 		PF00722
(Glyco_hydro_16) 		4 GLY A  17
SER A  15
ALA A  14
PHE A  18
 None
 1.02A 4m93B-1ajoA:
undetectable
4m93C-1ajoA:
2.0		 4m93B-1ajoA:
20.33
4m93C-1ajoA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1akp APOKEDARCIDIN

(actinomycete
ATCC 53650) 		PF00960
(Neocarzinostat) 		4 GLY A  25
SER A  24
ALA A  23
PHE A  26
 None
 0.87A 4m93B-1akpA:
4.5
4m93C-1akpA:
4.1		 4m93B-1akpA:
17.35
4m93C-1akpA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1axk GLUXYN-1

(Bacillus
subtilis) 		PF00457
(Glyco_hydro_11)
PF00722
(Glyco_hydro_16) 		4 GLY A  85
SER A  83
ALA A  82
PHE A  86
 None
 1.04A 4m93B-1axkA:
undetectable
4m93C-1axkA:
undetectable		 4m93B-1axkA:
20.56
4m93C-1axkA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0k PROTEIN (ACONITASE)

(Sus scrofa) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		4 GLY A 676
SER A 743
ALA A 744
PHE A 739
 None
 1.07A 4m93B-1b0kA:
undetectable
4m93C-1b0kA:
undetectable		 4m93B-1b0kA:
14.89
4m93C-1b0kA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1biy LACTOFERRIN

(Bubalus bubalis) 		PF00405
(Transferrin) 		4 SER A 480
ALA A 482
PHE A 486
GLU A 485
 None
 0.95A 4m93B-1biyA:
undetectable
4m93C-1biyA:
undetectable		 4m93B-1biyA:
15.82
4m93C-1biyA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpn CIRCULARLY PERMUTED

(Paenibacillus
macerans) 		PF00722
(Glyco_hydro_16) 		4 GLY A  85
SER A  83
ALA A  82
PHE A  86
 None
 1.01A 4m93B-1cpnA:
undetectable
4m93C-1cpnA:
undetectable		 4m93B-1cpnA:
23.14
4m93C-1cpnA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1czf POLYGALACTURONASE II

(Aspergillus
niger) 		PF00295
(Glyco_hydro_28) 		4 GLY A 101
ALA A 102
PHE A  74
GLU A  75
 None
 0.77A 4m93B-1czfA:
undetectable
4m93C-1czfA:
undetectable		 4m93B-1czfA:
22.07
4m93C-1czfA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dqs PROTEIN
(3-DEHYDROQUINATE
SYNTHASE)

(Aspergillus
nidulans) 		PF01761
(DHQ_synthase) 		4 GLY A 372
SER A 202
PHE A 207
GLU A 206
 None
 0.99A 4m93B-1dqsA:
undetectable
4m93C-1dqsA:
undetectable		 4m93B-1dqsA:
18.54
4m93C-1dqsA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gk2 HISTIDINE
AMMONIA-LYASE

(Pseudomonas
putida) 		PF00221
(Lyase_aromatic) 		4 GLY A 349
SER A 350
ALA A 392
GLU A 353
 None
 0.97A 4m93B-1gk2A:
undetectable
4m93C-1gk2A:
undetectable		 4m93B-1gk2A:
17.15
4m93C-1gk2A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iaw TYPE II RESTRICTION
ENZYME NAEI

(Lechevalieria
aerocolonigenes) 		PF09126
(NaeI) 		4 SER A 187
ALA A 188
PHE A 186
GLU A 203
 None
 1.07A 4m93B-1iawA:
undetectable
4m93C-1iawA:
undetectable		 4m93B-1iawA:
20.50
4m93C-1iawA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jd5 APOPTOSIS 1
INHIBITOR

(Drosophila
melanogaster) 		PF00653
(BIR) 		4 GLY A 251
ALA A 248
PHE A 264
GLU A 226
 None
 1.03A 4m93B-1jd5A:
undetectable
4m93C-1jd5A:
undetectable		 4m93B-1jd5A:
18.18
4m93C-1jd5A:
19.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kcv PC282 IMMUNOGLOBULIN
PC282 IMMUNOGLOBULIN

(Mus musculus;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		4 GLY H 130
SER H 131
ALA H 132
PHE L 209
 None
 0.91A 4m93B-1kcvH:
22.4
4m93C-1kcvH:
16.3		 4m93B-1kcvH:
62.56
4m93C-1kcvH:
28.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mac 1,3-1,4-BETA-D-GLUCA
N 4-GLUCANOHYDROLASE

(Paenibacillus
macerans) 		PF00722
(Glyco_hydro_16) 		4 GLY A 141
SER A 139
ALA A 138
PHE A 142
 None
 1.00A 4m93B-1macA:
undetectable
4m93C-1macA:
undetectable		 4m93B-1macA:
22.35
4m93C-1macA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1px5 2'-5'-OLIGOADENYLATE
SYNTHETASE 1

(Sus scrofa) 		PF01909
(NTP_transf_2)
PF10421
(OAS1_C) 		4 GLY A 254
ALA A 342
PHE A 255
GLU A 260
 None
 1.05A 4m93B-1px5A:
undetectable
4m93C-1px5A:
undetectable		 4m93B-1px5A:
20.12
4m93C-1px5A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qh4 CREATINE KINASE

(Gallus gallus) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		4 GLY A 163
SER A 164
ALA A 161
GLU A 160
 None
 0.98A 4m93B-1qh4A:
undetectable
4m93C-1qh4A:
undetectable		 4m93B-1qh4A:
21.56
4m93C-1qh4A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s5p NAD-DEPENDENT
DEACETYLASE

(Escherichia
coli) 		PF02146
(SIR2) 		4 GLY A  56
SER A  55
ALA A  53
GLU A  54
 None
 0.94A 4m93B-1s5pA:
undetectable
4m93C-1s5pA:
undetectable		 4m93B-1s5pA:
18.37
4m93C-1s5pA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqh CARBOXYLESTERASE
PRECURSOR

(Geobacillus
stearothermophilus) 		PF12146
(Hydrolase_4) 		4 GLY A  96
SER A  94
ALA A 117
PHE A  99
 None
4PA  A 701 (-1.4A)
None
None
 0.99A 4m93B-1tqhA:
undetectable
4m93C-1tqhA:
undetectable		 4m93B-1tqhA:
19.85
4m93C-1tqhA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tuo PUTATIVE
PHOSPHOMANNOMUTASE

(Thermus
thermophilus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 GLY A 175
ALA A 172
PHE A 176
GLU A 357
 None
 1.02A 4m93B-1tuoA:
undetectable
4m93C-1tuoA:
undetectable		 4m93B-1tuoA:
17.28
4m93C-1tuoA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uis RED FLUORESCENT
PROTEIN FP611

(Entacmaea
quadricolor) 		PF01353
(GFP) 		4 GLY A  37
ALA A 217
PHE A  69
GLU A 215
 None
ACY  A1001 (-3.6A)
None
ACY  A1001 (-3.2A)
 0.88A 4m93B-1uisA:
undetectable
4m93C-1uisA:
undetectable		 4m93B-1uisA:
21.48
4m93C-1uisA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqm KINDLING FLUORESCENT
PROTEIN

(Anemonia
sulcata) 		PF01353
(GFP) 		4 GLY A  37
ALA A 217
PHE A  69
GLU A 215
 None
None
None
CH6  A  63 ( 3.0A)
 0.93A 4m93B-1xqmA:
undetectable
4m93C-1xqmA:
undetectable		 4m93B-1xqmA:
22.27
4m93C-1xqmA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yx0 HYPOTHETICAL PROTEIN
YSNE

(Bacillus
subtilis) 		PF00583
(Acetyltransf_1) 		4 GLY A 112
SER A 113
PHE A 117
GLU A 118
 None
 1.06A 4m93B-1yx0A:
undetectable
4m93C-1yx0A:
undetectable		 4m93B-1yx0A:
19.20
4m93C-1yx0A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b1n SPE31

(Pachyrhizus
erosus) 		PF00112
(Peptidase_C1) 		4 GLY A  26
SER A  25
ALA A  28
GLU A  51
 None
 0.94A 4m93B-2b1nA:
undetectable
4m93C-2b1nA:
undetectable		 4m93B-2b1nA:
19.77
4m93C-2b1nA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bjs ISOPENICILLIN N
SYNTHETASE

(Aspergillus
nidulans) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		4 GLY A  40
SER A  36
ALA A  35
PHE A  41
 None
 0.79A 4m93B-2bjsA:
undetectable
4m93C-2bjsA:
undetectable		 4m93B-2bjsA:
20.98
4m93C-2bjsA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h6o MAJOR OUTER ENVELOPE
GLYCOPROTEIN GP350

(Human
gammaherpesvirus
4) 		PF05109
(Herpes_BLLF1) 		4 GLY A 294
SER A 293
ALA A 292
PHE A 284
 None
 0.87A 4m93B-2h6oA:
6.5
4m93C-2h6oA:
6.5		 4m93B-2h6oA:
20.42
4m93C-2h6oA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipx RRNA
2'-O-METHYLTRANSFERA
SE FIBRILLARIN

(Homo sapiens) 		PF01269
(Fibrillarin) 		4 GLY A 172
SER A 171
ALA A 170
GLU A 192
 None
None
MTA  A4001 (-3.6A)
MTA  A4001 (-2.7A)
 1.00A 4m93B-2ipxA:
undetectable
4m93C-2ipxA:
undetectable		 4m93B-2ipxA:
19.07
4m93C-2ipxA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfd FATTY ACID SYNTHASE

(Homo sapiens) 		PF00698
(Acyl_transf_1)
PF16197
(KAsynt_C_assoc) 		4 GLY A 428
SER A 427
ALA A 426
PHE A 467
 None
 1.05A 4m93B-2jfdA:
undetectable
4m93C-2jfdA:
undetectable		 4m93B-2jfdA:
20.09
4m93C-2jfdA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kno TENSIN-LIKE C1
DOMAIN-CONTAINING
PHOSPHATASE

(Homo sapiens) 		PF00017
(SH2) 		4 GLY A  57
SER A  49
ALA A  55
GLU A  87
 None
 1.01A 4m93B-2knoA:
undetectable
4m93C-2knoA:
undetectable		 4m93B-2knoA:
22.48
4m93C-2knoA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6x SECRETED CATHEPSIN L
1

(Fasciola
hepatica) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		4 GLY A 123
SER A 122
ALA A 125
GLU A 148
 None
 1.01A 4m93B-2o6xA:
undetectable
4m93C-2o6xA:
undetectable		 4m93B-2o6xA:
22.15
4m93C-2o6xA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og7 ASPARAGINE OXYGENASE

(Streptomyces
coelicolor) 		PF02668
(TauD) 		4 GLY A 148
SER A 149
PHE A 143
GLU A 142
 None
 1.06A 4m93B-2og7A:
undetectable
4m93C-2og7A:
undetectable		 4m93B-2og7A:
20.17
4m93C-2og7A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2otb GFP-LIKE FLUORESCENT
CHROMOPROTEIN CFP484

(Clavularia sp.) 		PF01353
(GFP) 		4 GLY A  40
SER A 216
ALA A 217
PHE A  72
 None
 1.04A 4m93B-2otbA:
undetectable
4m93C-2otbA:
undetectable		 4m93B-2otbA:
18.44
4m93C-2otbA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p17 PIRIN-LIKE PROTEIN

(Geobacillus
kaustophilus) 		PF02678
(Pirin)
PF05726
(Pirin_C) 		4 GLY A 106
SER A 107
ALA A 104
GLU A  70
 None
 1.07A 4m93B-2p17A:
undetectable
4m93C-2p17A:
2.0		 4m93B-2p17A:
20.00
4m93C-2p17A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 GLY A 821
SER A 820
ALA A 818
GLU A 819
 None
 1.02A 4m93B-2qo3A:
undetectable
4m93C-2qo3A:
undetectable		 4m93B-2qo3A:
12.21
4m93C-2qo3A:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qua EXTRACELLULAR LIPASE

(Serratia
marcescens) 		no annotation 4 GLY A 205
ALA A  28
PHE A 140
GLU A 122
 None
 1.04A 4m93B-2quaA:
undetectable
4m93C-2quaA:
undetectable		 4m93B-2quaA:
15.28
4m93C-2quaA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rf4 DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA4

(Saccharomyces
cerevisiae) 		PF03876
(SHS2_Rpb7-N) 		4 GLY A 146
SER A 156
ALA A 155
PHE A 138
 None
 0.98A 4m93B-2rf4A:
undetectable
4m93C-2rf4A:
undetectable		 4m93B-2rf4A:
18.53
4m93C-2rf4A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Homo sapiens) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		4 GLY A 383
SER A 382
ALA A 381
GLU A 334
 XMP  A1694 (-3.4A)
None
None
None
 1.04A 4m93B-2vxoA:
undetectable
4m93C-2vxoA:
undetectable		 4m93B-2vxoA:
16.08
4m93C-2vxoA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w38 SIALIDASE

(Pseudomonas
aeruginosa) 		PF13088
(BNR_2) 		5 GLY A 296
SER A 295
ALA A 294
PHE A 313
GLU A 315
 None
 1.24A 4m93B-2w38A:
undetectable
4m93C-2w38A:
2.1		 4m93B-2w38A:
20.45
4m93C-2w38A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2m PENICILLIN-BINDING
PROTEIN 2X

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		4 GLY B 549
SER B 548
ALA B 572
PHE B 570
 CDS  B 901 ( 3.4A)
CDS  B 901 ( 2.9A)
None
None
 0.96A 4m93B-2z2mB:
undetectable
4m93C-2z2mB:
undetectable		 4m93B-2z2mB:
23.65
4m93C-2z2mB:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a77 INTERFERON
REGULATORY FACTOR 3

(Homo sapiens) 		PF10401
(IRF-3) 		4 GLY A 337
SER A 336
PHE A 332
GLU A 334
 None
 1.00A 4m93B-3a77A:
undetectable
4m93C-3a77A:
undetectable		 4m93B-3a77A:
23.70
4m93C-3a77A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3agr NUCLEOSIDE
TRIPHOSPHATE
HYDROLASE

(Neospora
caninum) 		PF01150
(GDA1_CD39) 		4 GLY A 446
ALA A 438
PHE A 447
GLU A 448
 None
 0.90A 4m93B-3agrA:
undetectable
4m93C-3agrA:
undetectable		 4m93B-3agrA:
16.98
4m93C-3agrA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cfh GFP-LIKE
PHOTOSWITCHABLE
FLUORESCENT PROTEIN
GFP-LIKE
PHOTOSWITCHABLE
FLUORESCENT PROTEIN

(Anemonia
sulcata;
Anemonia
sulcata) 		PF01353
(GFP)
PF01353
(GFP) 		4 GLY L  37
ALA A 216
PHE A  69
GLU A 214
 None
None
None
NRQ  A  65 ( 3.1A)
 0.89A 4m93B-3cfhL:
undetectable
4m93C-3cfhL:
undetectable		 4m93B-3cfhL:
15.42
4m93C-3cfhL:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d9u BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF00653
(BIR) 		4 GLY A 288
SER A 286
ALA A 285
PHE A 301
 None
 1.07A 4m93B-3d9uA:
undetectable
4m93C-3d9uA:
undetectable		 4m93B-3d9uA:
17.06
4m93C-3d9uA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dms ISOCITRATE
DEHYDROGENASE [NADP]

(Burkholderia
pseudomallei) 		PF00180
(Iso_dh) 		4 GLY A 327
ALA A 339
PHE A 337
GLU A 358
 None
 0.93A 4m93B-3dmsA:
undetectable
4m93C-3dmsA:
undetectable		 4m93B-3dmsA:
20.15
4m93C-3dmsA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3euj CHROMOSOME PARTITION
PROTEIN MUKB, LINKER

([Haemophilus]
ducreyi) 		PF04310
(MukB)
PF13558
(SbcCD_C) 		4 GLY A  65
SER A  64
ALA A1462
GLU A1464
 None
 0.92A 4m93B-3eujA:
undetectable
4m93C-3eujA:
undetectable		 4m93B-3eujA:
16.96
4m93C-3eujA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gq2 GENERAL VESICULAR
TRANSPORT FACTOR
P115

(Bos taurus) 		PF04869
(Uso1_p115_head) 		4 GLY A 110
SER A 111
PHE A 113
GLU A 115
 None
 0.94A 4m93B-3gq2A:
undetectable
4m93C-3gq2A:
undetectable		 4m93B-3gq2A:
16.93
4m93C-3gq2A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbx GLUTAMATE
DECARBOXYLASE 1

(Arabidopsis
thaliana) 		PF00282
(Pyridoxal_deC) 		4 GLY A 216
SER A 212
PHE A 218
GLU A 219
 None
 1.04A 4m93B-3hbxA:
undetectable
4m93C-3hbxA:
undetectable		 4m93B-3hbxA:
17.64
4m93C-3hbxA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhd FATTY ACID SYNTHASE

(Homo sapiens) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 GLY A 428
SER A 427
ALA A 426
PHE A 467
 None
 1.03A 4m93B-3hhdA:
undetectable
4m93C-3hhdA:
undetectable		 4m93B-3hhdA:
13.05
4m93C-3hhdA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3id3 REGULATOR OF SIGMA E
PROTEASE

(Escherichia
coli) 		PF00595
(PDZ) 		5 GLY A 303
SER A 233
ALA A 234
PHE A 301
GLU A 290
 None
 1.33A 4m93B-3id3A:
undetectable
4m93C-3id3A:
undetectable		 4m93B-3id3A:
18.06
4m93C-3id3A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ir8 LARGE STOKES SHIFT
FLUORESCENT PROTEIN

(Montipora sp.
20) 		PF01353
(GFP) 		4 GLY A  36
ALA A 213
PHE A  68
GLU A 211
 None
None
None
CRQ  A  64 ( 3.3A)
 1.00A 4m93B-3ir8A:
undetectable
4m93C-3ir8A:
undetectable		 4m93B-3ir8A:
20.48
4m93C-3ir8A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nsj PERFORIN-1

(Mus musculus) 		PF00168
(C2)
PF01823
(MACPF) 		4 SER A 170
ALA A 108
PHE A 168
GLU A 119
 None
 0.90A 4m93B-3nsjA:
undetectable
4m93C-3nsjA:
undetectable		 4m93B-3nsjA:
17.86
4m93C-3nsjA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogk CORONATINE-INSENSITI
VE PROTEIN 1

(Arabidopsis
thaliana) 		no annotation 4 GLY B 251
SER B 252
PHE B 230
GLU B 231
 None
 0.91A 4m93B-3ogkB:
undetectable
4m93C-3ogkB:
undetectable		 4m93B-3ogkB:
17.06
4m93C-3ogkB:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oz1 BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF00653
(BIR) 		4 GLY A 288
SER A 286
ALA A 285
PHE A 301
 None
 1.06A 4m93B-3oz1A:
undetectable
4m93C-3oz1A:
undetectable		 4m93B-3oz1A:
17.27
4m93C-3oz1A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdi NITROGENASE MOFE
COFACTOR
BIOSYNTHESIS PROTEIN
NIFN

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro) 		4 GLY B  40
SER B  41
ALA B  66
PHE B  38
 None
SF4  A 501 ( 4.6A)
None
None
 0.85A 4m93B-3pdiB:
undetectable
4m93C-3pdiB:
undetectable		 4m93B-3pdiB:
20.44
4m93C-3pdiB:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q6t 43.2 KDA SALIVARY
PROTEIN

(Lutzomyia
longipalpis) 		PF03022
(MRJP) 		4 GLY A 243
SER A 244
ALA A 203
PHE A 178
 None
 1.05A 4m93B-3q6tA:
undetectable
4m93C-3q6tA:
undetectable		 4m93B-3q6tA:
21.41
4m93C-3q6tA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r64 NAD DEPENDENT
BENZALDEHYDE
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF00171
(Aldedh) 		4 SER A 233
ALA A 258
PHE A 234
GLU A 260
 SER  A 233 ( 0.0A)
ALA  A 258 ( 0.0A)
PHE  A 234 ( 1.3A)
GLU  A 260 ( 0.6A)
 1.04A 4m93B-3r64A:
undetectable
4m93C-3r64A:
undetectable		 4m93B-3r64A:
16.27
4m93C-3r64A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rcn BETA-N-ACETYLHEXOSAM
INIDASE

(Paenarthrobacter
aurescens) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b) 		4 GLY A 202
SER A 203
ALA A 206
GLU A 526
 None
GOL  A 556 ( 4.9A)
None
None
 1.06A 4m93B-3rcnA:
undetectable
4m93C-3rcnA:
undetectable		 4m93B-3rcnA:
16.58
4m93C-3rcnA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rhd LACTALDEHYDE
DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF00171
(Aldedh) 		4 SER A 218
ALA A 239
PHE A 219
GLU A 241
 None
None
NAP  A 500 (-4.4A)
None
 1.00A 4m93B-3rhdA:
undetectable
4m93C-3rhdA:
undetectable		 4m93B-3rhdA:
16.31
4m93C-3rhdA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwa FLUORESCENT PROTEIN
FP480

(Entacmaea
quadricolor) 		PF01353
(GFP) 		4 GLY A 107
ALA A  50
PHE A 139
GLU A  48
 None
None
None
NRQ  A 133 ( 3.9A)
 1.06A 4m93B-3rwaA:
undetectable
4m93C-3rwaA:
undetectable		 4m93B-3rwaA:
19.44
4m93C-3rwaA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sy8 ROCR

(Pseudomonas
aeruginosa) 		PF00072
(Response_reg)
PF00563
(EAL) 		4 GLY A 291
ALA A 293
PHE A 264
GLU A 265
 None
None
None
MG  A 401 (-3.4A)
 0.85A 4m93B-3sy8A:
undetectable
4m93C-3sy8A:
undetectable		 4m93B-3sy8A:
21.26
4m93C-3sy8A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0k RCAMP

(Entacmaea
quadricolor) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		4 GLY A 188
ALA A 135
PHE A 220
GLU A 133
 None
ACT  A 443 (-3.5A)
None
ACT  A 443 (-2.7A)
 1.01A 4m93B-3u0kA:
undetectable
4m93C-3u0kA:
undetectable		 4m93B-3u0kA:
18.45
4m93C-3u0kA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0n MRUBY

(Entacmaea
quadricolor) 		PF01353
(GFP) 		4 GLY A  37
ALA A 217
PHE A  69
GLU A 215
 None
None
None
NRQ  A  64 ( 3.0A)
 1.05A 4m93B-3u0nA:
undetectable
4m93C-3u0nA:
undetectable		 4m93B-3u0nA:
20.59
4m93C-3u0nA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u5t 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		4 GLY A 116
SER A  64
ALA A 111
PHE A 118
 None
 1.05A 4m93B-3u5tA:
undetectable
4m93C-3u5tA:
undetectable		 4m93B-3u5tA:
21.98
4m93C-3u5tA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujz METALLOPROTEASE STCE

(Escherichia
coli) 		PF10462
(Peptidase_M66) 		4 GLY A 295
ALA A 293
PHE A 545
GLU A 546
 None
 1.00A 4m93B-3ujzA:
3.3
4m93C-3ujzA:
4.6		 4m93B-3ujzA:
14.20
4m93C-3ujzA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v2h D-BETA-HYDROXYBUTYRA
TE DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		4 GLY A 175
SER A 174
ALA A 172
GLU A 173
 None
 0.95A 4m93B-3v2hA:
undetectable
4m93C-3v2hA:
undetectable		 4m93B-3v2hA:
20.89
4m93C-3v2hA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vgl GLUCOKINASE

(Streptomyces
griseus) 		PF00480
(ROK) 		4 GLY A 305
ALA A 301
PHE A 116
GLU A 113
 None
 1.04A 4m93B-3vglA:
undetectable
4m93C-3vglA:
undetectable		 4m93B-3vglA:
19.50
4m93C-3vglA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a7k ALDOS-2-ULOSE
DEHYDRATASE

(Phanerochaete
chrysosporium) 		no annotation 4 GLY A 273
SER A 274
ALA A 291
PHE A 294
 None
 0.99A 4m93B-4a7kA:
undetectable
4m93C-4a7kA:
undetectable		 4m93B-4a7kA:
13.24
4m93C-4a7kA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a94 CARBOXYPEPTIDASE
INHIBITOR

(Nerita
versicolor) 		no annotation 4 GLY C  35
ALA C  30
PHE C  34
GLU C  37
 None
 0.94A 4m93B-4a94C:
undetectable
4m93C-4a94C:
undetectable		 4m93B-4a94C:
11.67
4m93C-4a94C:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ain GLYCINE BETAINE
TRANSPORTER BETP

(Corynebacterium
glutamicum) 		PF02028
(BCCT) 		4 GLY A 264
SER A 266
ALA A 267
GLU A 438
 None
 1.03A 4m93B-4ainA:
undetectable
4m93C-4ainA:
undetectable		 4m93B-4ainA:
17.10
4m93C-4ainA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bh6 APC/C ACTIVATOR
PROTEIN CDH1

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		4 GLY A 360
SER A 361
ALA A 348
GLU A 387
 None
 1.04A 4m93B-4bh6A:
undetectable
4m93C-4bh6A:
undetectable		 4m93B-4bh6A:
19.81
4m93C-4bh6A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3h DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA43

(Saccharomyces
cerevisiae) 		PF03876
(SHS2_Rpb7-N) 		4 GLY G 146
SER G 156
ALA G 155
PHE G 138
 None
 0.91A 4m93B-4c3hG:
undetectable
4m93C-4c3hG:
undetectable		 4m93B-4c3hG:
18.67
4m93C-4c3hG:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czb NA(+)/H(+)
ANTIPORTER 1

(Methanocaldococcus
jannaschii) 		PF00999
(Na_H_Exchanger) 		4 GLY A 314
SER A 315
ALA A 319
PHE A 317
 None
 0.95A 4m93B-4czbA:
undetectable
4m93C-4czbA:
undetectable		 4m93B-4czbA:
18.40
4m93C-4czbA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dqd EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Rhodopseudomonas
palustris) 		PF13458
(Peripla_BP_6) 		4 GLY A 221
ALA A  39
PHE A 251
GLU A 250
 None
GOL  A 402 ( 3.8A)
None
PG4  A 405 ( 3.9A)
 1.04A 4m93B-4dqdA:
undetectable
4m93C-4dqdA:
undetectable		 4m93B-4dqdA:
20.78
4m93C-4dqdA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4g METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		4 GLY A 273
SER A 274
ALA A 275
GLU A 277
 None
 1.01A 4m93B-4e4gA:
undetectable
4m93C-4e4gA:
undetectable		 4m93B-4e4gA:
16.54
4m93C-4e4gA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4egv ACETYL-COA
ACETYLTRANSFERASE

(Mycolicibacterium
smegmatis) 		no annotation 4 GLY A 396
SER A 400
ALA A 399
GLU A 291
 None
 1.01A 4m93B-4egvA:
undetectable
4m93C-4egvA:
undetectable		 4m93B-4egvA:
15.89
4m93C-4egvA:
18.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f15 FAB FRAGMENT, HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLY B  25
SER B  24
ALA B  23
PHE B  26
 None
 0.99A 4m93B-4f15B:
19.9
4m93C-4f15B:
15.0		 4m93B-4f15B:
55.11
4m93C-4f15B:
30.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k2x POLYKETIDE
OXYGENASE/HYDROXYLAS
E

(Streptomyces
rimosus) 		PF01494
(FAD_binding_3) 		4 GLY A  62
ALA A  65
PHE A  63
GLU A  66
 None
 1.01A 4m93B-4k2xA:
undetectable
4m93C-4k2xA:
undetectable		 4m93B-4k2xA:
17.27
4m93C-4k2xA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mca GLYCEROL
DEHYDROGENASE

(Serratia
plymuthica) 		PF00465
(Fe-ADH) 		4 GLY A 249
SER A 248
ALA A 179
PHE A 245
 None
None
None
GOL  A1002 (-3.6A)
 0.95A 4m93B-4mcaA:
undetectable
4m93C-4mcaA:
undetectable		 4m93B-4mcaA:
21.95
4m93C-4mcaA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ohs FAR-RED FLUORESCENT
PROTEIN AQ143

(Actinia equina) 		PF01353
(GFP) 		4 GLY A  37
ALA A 216
PHE A  69
GLU A 214
 None
None
None
CH6  A  63 ( 2.8A)
 0.89A 4m93B-4ohsA:
undetectable
4m93C-4ohsA:
undetectable		 4m93B-4ohsA:
22.00
4m93C-4ohsA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ohs FAR-RED FLUORESCENT
PROTEIN AQ143

(Actinia equina) 		PF01353
(GFP) 		4 GLY A  37
SER A 215
ALA A 216
PHE A  69
 None
 1.01A 4m93B-4ohsA:
undetectable
4m93C-4ohsA:
undetectable		 4m93B-4ohsA:
22.00
4m93C-4ohsA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pq9 BETA-1,3-GLUCANASE

(Mycobacterium
marinum) 		PF00722
(Glyco_hydro_16) 		4 GLY A  41
SER A  42
ALA A  43
PHE A  81
 None
 1.05A 4m93B-4pq9A:
undetectable
4m93C-4pq9A:
undetectable		 4m93B-4pq9A:
20.38
4m93C-4pq9A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pwo DSBA

(Corynebacterium
diphtheriae) 		PF13462
(Thioredoxin_4) 		4 GLY A 260
SER A 259
ALA A 250
PHE A 128
 None
 1.05A 4m93B-4pwoA:
undetectable
4m93C-4pwoA:
undetectable		 4m93B-4pwoA:
20.24
4m93C-4pwoA:
22.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uao IMMUNOGLOBULIN R31C2
LIGHT CHAIN
IMMUNOGLOBULIN R31C2
VH AND CH1 REGIONS

(Rattus
norvegicus;
Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		4 GLY C 127
ALA C 129
PHE B 209
GLU B 213
 None
 0.94A 4m93B-4uaoC:
22.8
4m93C-4uaoC:
16.3		 4m93B-4uaoC:
67.87
4m93C-4uaoC:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 THE
ANAPHASE-PROMOTING
COMPLEX CHAIN R

(Homo sapiens) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		4 GLY R 284
SER R 285
ALA R 272
GLU R 311
 None
 0.99A 4m93B-5a31R:
undetectable
4m93C-5a31R:
undetectable		 4m93B-5a31R:
21.35
4m93C-5a31R:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b13 PHYCOERYTHRIN BETA
SUBUNIT

(Palmaria
palmata) 		PF00502
(Phycobilisome) 		4 GLY G 144
SER G 143
ALA G 140
PHE G  43
 CYC  G 202 ( 3.9A)
None
PUB  G 203 ( 3.9A)
None
 1.06A 4m93B-5b13G:
undetectable
4m93C-5b13G:
undetectable		 4m93B-5b13G:
21.00
4m93C-5b13G:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dxd PUTATIVE
BETA-GLUCANASE

(Mycobacteroides
abscessus) 		PF00722
(Glyco_hydro_16) 		4 GLY A  37
SER A  38
ALA A  39
PHE A  77
 None
 1.01A 4m93B-5dxdA:
undetectable
4m93C-5dxdA:
undetectable		 4m93B-5dxdA:
22.26
4m93C-5dxdA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5inf CARBOXYL TRANSFERASE

(Streptomyces
ambofaciens) 		PF01039
(Carboxyl_trans) 		4 GLY A 119
SER A 120
ALA A 117
GLU A 116
 None
 1.02A 4m93B-5infA:
undetectable
4m93C-5infA:
undetectable		 4m93B-5infA:
17.93
4m93C-5infA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5inw PUTATIVE
ANGIOTENSINOGEN

(Lampetra
fluviatilis) 		PF00079
(Serpin) 		4 GLY A 249
SER A 250
PHE A 167
GLU A 302
 None
 1.01A 4m93B-5inwA:
undetectable
4m93C-5inwA:
undetectable		 4m93B-5inwA:
21.04
4m93C-5inwA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m3h POLYMERASE ACIDIC
PROTEIN

(Influenza A
virus) 		PF00603
(Flu_PA) 		4 GLY A 674
SER A 259
PHE A 676
GLU A 258
 None
 1.04A 4m93B-5m3hA:
undetectable
4m93C-5m3hA:
undetectable		 4m93B-5m3hA:
13.24
4m93C-5m3hA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5my0 FATTY ACID SYNTHASE

(Mus musculus) 		no annotation 4 GLY B 428
SER B 427
ALA B 426
PHE B 467
 None
 0.99A 4m93B-5my0B:
undetectable
4m93C-5my0B:
undetectable		 4m93B-5my0B:
undetectable
4m93C-5my0B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ukg K-GECO

(Entacmaea
quadricolor) 		no annotation 4 GLY A 159
ALA A 106
PHE A 191
GLU A 104
 None
None
None
NRQ  A 186 ( 3.6A)
 0.97A 4m93B-5ukgA:
undetectable
4m93C-5ukgA:
undetectable		 4m93B-5ukgA:
undetectable
4m93C-5ukgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vm1 XYLULOKINASE

(Brucella ovis) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 GLY A 242
SER A 239
ALA A 238
PHE A 427
 None
 1.00A 4m93B-5vm1A:
undetectable
4m93C-5vm1A:
undetectable		 4m93B-5vm1A:
20.82
4m93C-5vm1A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wvo DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Homo sapiens) 		no annotation 4 GLY C 437
SER C 438
ALA C 439
PHE C 410
 None
 1.01A 4m93B-5wvoC:
undetectable
4m93C-5wvoC:
undetectable		 4m93B-5wvoC:
21.13
4m93C-5wvoC:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xn8 GLYCEROL
DEHYDROGENASE

(unidentified) 		PF00465
(Fe-ADH) 		4 GLY A 249
SER A 248
ALA A 179
PHE A 245
 None
 0.91A 4m93B-5xn8A:
undetectable
4m93C-5xn8A:
undetectable		 4m93B-5xn8A:
21.72
4m93C-5xn8A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnc -

(-) 		no annotation 4 GLY A 238
ALA A 242
PHE A 332
GLU A 333
 None
 1.06A 4m93B-5xncA:
undetectable
4m93C-5xncA:
undetectable		 4m93B-5xncA:
undetectable
4m93C-5xncA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtg 2,3-DIHYDROXY-2,3-DI
HYDROPHENYLPROPIONAT
E DEHYDROGENASE

(Pseudomonas sp.
MC1) 		PF13561
(adh_short_C2) 		4 GLY B 120
SER B 122
ALA B 123
GLU B  66
 None
 1.07A 4m93B-5xtgB:
undetectable
4m93C-5xtgB:
undetectable		 4m93B-5xtgB:
20.79
4m93C-5xtgB:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y00 GREEN FLUORESCENT
PROTEIN

(Olindias) 		no annotation 4 GLY A  45
ALA A 225
PHE A  76
GLU A 223
 None
None
None
CRQ  A  70 ( 2.7A)
 1.04A 4m93B-5y00A:
undetectable
4m93C-5y00A:
undetectable		 4m93B-5y00A:
undetectable
4m93C-5y00A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5za2 BETA-LACTAMASE

(Escherichia
coli) 		no annotation 4 GLY A 227
SER A 228
ALA A 229
GLU A  56
 None
 0.73A 4m93B-5za2A:
undetectable
4m93C-5za2A:
undetectable		 4m93B-5za2A:
undetectable
4m93C-5za2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bb4 MOUSE MONOCLONAL
ANTIBODY C5.2 FAB
HEAVY CHAIN
MOUSE MONOCLONAL
ANTIBODY C5.2 FAB
LIGHT CHAIN

(Mus musculus;
Mus musculus) 		no annotation
no annotation 		4 GLY H 127
SER H 128
ALA H 129
PHE L 209
 None
 0.86A 4m93B-6bb4H:
23.5
4m93C-6bb4H:
17.5		 4m93B-6bb4H:
undetectable
4m93C-6bb4H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cnk IGG1 KAPPA LIGHT
CHAIN
IGG1 HEAVY CHAIN

(Mus musculus;
Mus musculus) 		no annotation
no annotation 		4 GLY G 134
SER G 135
ALA G 136
PHE F 214
 None
 0.71A 4m93B-6cnkG:
21.7
4m93C-6cnkG:
16.4		 4m93B-6cnkG:
undetectable
4m93C-6cnkG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eid ARCHAEAL-TYPE OPSIN
2

(Chlamydomonas
reinhardtii) 		no annotation 4 GLY A 163
SER A 166
ALA A 167
GLU A 235
 LYR  A 257 ( 3.7A)
None
None
None
 1.07A 4m93B-6eidA:
undetectable
4m93C-6eidA:
undetectable		 4m93B-6eidA:
undetectable
4m93C-6eidA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gu8 -

(-) 		no annotation 4 GLY A 357
ALA A 286
PHE A 355
GLU A 354
 None
 1.00A 4m93B-6gu8A:
undetectable
4m93C-6gu8A:
undetectable		 4m93B-6gu8A:
undetectable
4m93C-6gu8A:
undetectable