SIMILAR PATTERNS OF AMINO ACIDS FOR 4M83_B_ERYB501_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1izo CYTOCHROME P450
152A1

(Bacillus
subtilis) 		PF00067
(p450) 		5 TRP A 193
PHE A 166
ILE A 244
ALA A 246
SER A 248
 None
None
HEM  A 501 ( 4.7A)
PAM  A 601 (-3.9A)
None
 1.44A 4m83B-1izoA:
undetectable		 4m83B-1izoA:
23.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2iyf OLEANDOMYCIN
GLYCOSYLTRANSFERASE

(Streptomyces
antibioticus) 		PF00201
(UDPGT) 		11 HIS A  19
TRP A  73
ASN A  80
VAL A  81
PHE A  84
ILE A 111
TYR A 114
ASN A 133
TYR A 140
ALA A 182
SER A 183
 ERY  A1400 (-3.9A)
ERY  A1400 (-3.8A)
ERY  A1400 (-3.7A)
ERY  A1400 (-4.6A)
ERY  A1400 ( 3.8A)
ERY  A1400 ( 3.8A)
None
ERY  A1400 (-3.6A)
ERY  A1400 ( 4.5A)
ERY  A1400 (-3.6A)
ERY  A1400 (-2.8A)
 0.34A 4m83B-2iyfA:
undetectable		 4m83B-2iyfA:
99.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j5c 1,8-CINEOLE SYNTHASE

(Salvia
fruticosa) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 HIS A 454
TRP A 367
ASN A 388
ILE A 337
ALA A 339
 None
None
None
None
BME  A1593 ( 4.8A)
 1.47A 4m83B-2j5cA:
undetectable		 4m83B-2j5cA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1z RIBONUCLEOTIDE
REDUCTASE SUBUNIT R2

(Plasmodium
vivax) 		PF00268
(Ribonuc_red_sm) 		5 ASN A 250
VAL A 247
TYR A 236
ALA A 181
SER A 179
 None
 1.29A 4m83B-2o1zA:
undetectable		 4m83B-2o1zA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xvs TETRATRICOPEPTIDE
REPEAT PROTEIN 5

(Homo sapiens) 		PF16669
(TTC5_OB) 		5 ASN A 390
VAL A 331
ILE A 337
TYR A 309
ALA A 335
 None
 1.46A 4m83B-2xvsA:
undetectable		 4m83B-2xvsA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al9 PLEXIN-A2

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI) 		5 VAL A 188
ILE A 226
TYR A 243
TYR A 215
SER A 199
 None
 1.34A 4m83B-3al9A:
undetectable		 4m83B-3al9A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3apo DNAJ HOMOLOG
SUBFAMILY C MEMBER
10

(Mus musculus) 		PF00085
(Thioredoxin)
PF00226
(DnaJ) 		5 ASN A 152
VAL A 151
PHE A 150
ASN A 217
ALA A 213
 None
 1.11A 4m83B-3apoA:
undetectable		 4m83B-3apoA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ba3 PYRIDOXAMINE
5'-PHOSPHATE
OXIDASE-LIKE PROTEIN

(Lactobacillus
plantarum) 		no annotation 5 ASN A  32
VAL A  31
TYR A  57
ALA A  53
SER A  51
 EDO  A 148 ( 3.6A)
None
None
None
None
 1.31A 4m83B-3ba3A:
undetectable		 4m83B-3ba3A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e03 SHORT CHAIN
DEHYDROGENASE

(Xanthomonas
campestris) 		PF13561
(adh_short_C2) 		5 HIS A  52
ASN A  59
VAL A  58
ILE A  51
ALA A  15
 None
 1.28A 4m83B-3e03A:
undetectable		 4m83B-3e03A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3faw RETICULOCYTE BINDING
PROTEIN

(Streptococcus
agalactiae) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 ASN A 590
VAL A 589
TYR A 548
ASN A 479
ALA A 566
 None
 1.25A 4m83B-3fawA:
undetectable		 4m83B-3fawA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3j L-LACTATE
DEHYDROGENASE 1

(Staphylococcus
aureus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ASN A   7
VAL A  31
ILE A 243
TYR A  21
ALA A 241
 None
 1.43A 4m83B-3h3jA:
undetectable		 4m83B-3h3jA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9f PUTATIVE TYPE 11
METHYLTRANSFERASE

(Sulfolobus
solfataricus) 		PF08241
(Methyltransf_11) 		5 ASN A 161
ILE A 123
TYR A  45
TYR A 147
ALA A  96
 None
 1.43A 4m83B-3i9fA:
undetectable		 4m83B-3i9fA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3il4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Enterococcus
faecalis) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 TRP A 153
ILE A  45
ASN A  25
ALA A 252
SER A 253
 None
None
None
ACO  A 401 (-3.5A)
None
 1.49A 4m83B-3il4A:
undetectable		 4m83B-3il4A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8o 6-PHOSPHOFRUCTOKINAS
E SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF00365
(PFK) 		5 TRP B 626
ASN B 593
VAL B 684
ILE B 589
ALA B 875
 None
 1.48A 4m83B-3o8oB:
undetectable		 4m83B-3o8oB:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oky PLEXIN-A2

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI) 		5 VAL A 188
ILE A 226
TYR A 243
TYR A 215
SER A 199
 None
 1.37A 4m83B-3okyA:
undetectable		 4m83B-3okyA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3teb ENDONUCLEASE/EXONUCL
EASE/PHOSPHATASE

(Leptotrichia
buccalis) 		PF03372
(Exo_endo_phos) 		5 HIS A 254
ASN A  41
VAL A  40
ALA A  36
SER A 138
 None
 1.50A 4m83B-3tebA:
undetectable		 4m83B-3tebA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w3e COTYLEDONEOUS
YIELDIN-LIKE PROTEIN

(Vigna
unguiculata) 		PF00182
(Glyco_hydro_19) 		5 ASN A  52
VAL A 227
TYR A 218
ASN A 173
ALA A  60
 None
 1.45A 4m83B-3w3eA:
undetectable		 4m83B-3w3eA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1

(Mus musculus) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		5 ASN A 293
VAL A 290
ILE A 562
TYR A 552
ALA A 564
 None
 0.91A 4m83B-4b56A:
undetectable		 4m83B-4b56A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f8x ENDO-1,4-BETA-XYLANA
SE

(Penicillium
canescens) 		PF00331
(Glyco_hydro_10) 		5 HIS A 138
TRP A 153
VAL A 156
ALA A 114
SER A 169
 None
 1.47A 4m83B-4f8xA:
undetectable		 4m83B-4f8xA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mix PUTATIVE
INSECTICIDAL TOXIN

(Photorhabdus
asymbiotica) 		PF04488
(Gly_transf_sug) 		5 ASN A2180
ILE A2171
TYR A2274
ALA A2256
SER A2259
 None
UD1  A2502 (-4.2A)
None
UD1  A2502 (-3.6A)
UD1  A2502 (-2.9A)
 1.44A 4m83B-4mixA:
undetectable		 4m83B-4mixA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nt9 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
pneumoniae) 		no annotation 5 HIS B  79
ASN B  59
VAL B  58
ASN B  77
ALA B  55
 None
 1.46A 4m83B-4nt9B:
undetectable		 4m83B-4nt9B:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pc4 30K LIPOPROTEIN

(Bombyx mori) 		PF03260
(Lipoprotein_11) 		5 ASN A  52
VAL A  49
TYR A  64
ALA A  30
SER A  21
 MES  A 302 (-3.3A)
None
None
None
None
 1.47A 4m83B-4pc4A:
undetectable		 4m83B-4pc4A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xg1 DIAMINOPIMELATE
DECARBOXYLASE

(Psychromonas
ingrahamii) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 HIS A  41
VAL A  68
TYR A  58
ASN A 282
ALA A  62
 None
None
None
None
LLP  A 508 ( 4.8A)
 1.49A 4m83B-4xg1A:
undetectable		 4m83B-4xg1A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7h IPT/TIG
DOMAIN-CONTAINING
PROTEIN BACOVA_02650

(Bacteroides
ovatus) 		PF01833
(TIG) 		5 HIS A 296
ASN A 317
VAL A 487
ASN A 264
SER A 239
 None
 1.35A 4m83B-5e7hA:
undetectable		 4m83B-5e7hA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ed8 MKIAA0668 PROTEIN

(Mus musculus) 		PF07738
(Sad1_UNC) 		5 VAL A 611
ASN A 618
TYR A 685
ALA A 624
SER A 623
 None
 1.48A 4m83B-5ed8A:
undetectable		 4m83B-5ed8A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5g PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT

(Escherichia
coli;
Escherichia
coli) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 HIS C 109
TYR C  52
ASN B 126
ALA C 127
SER C 128
 None
 1.16A 4m83B-5g5gC:
undetectable		 4m83B-5g5gC:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l5g PLEXIN-A2

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG) 		5 VAL A 188
ILE A 226
TYR A 243
TYR A 215
SER A 199
 None
 1.34A 4m83B-5l5gA:
undetectable		 4m83B-5l5gA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szn PROTOCADHERIN GAMMA
A9

(Mus musculus) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		5 VAL A 130
TYR A 142
ASN A  99
ALA A 186
SER A 196
 None
None
CA  A 615 (-3.4A)
None
None
 1.29A 4m83B-5sznA:
undetectable		 4m83B-5sznA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t4m PROTOCADHERIN-15

(Homo sapiens) 		PF00028
(Cadherin) 		5 VAL A 513
TYR A 525
ASN A 482
ALA A 564
SER A 576
 None
None
CA  A 705 (-3.0A)
None
None
 1.41A 4m83B-5t4mA:
undetectable		 4m83B-5t4mA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6avy ACYL-PROTEIN
THIOESTERASE 2

(Zea mays) 		no annotation 5 ASN A 153
VAL A 152
TYR A 144
ALA A 104
SER A 135
 None
 1.32A 4m83B-6avyA:
undetectable		 4m83B-6avyA:
undetectable