SIMILAR PATTERNS OF AMINO ACIDS FOR 4M83_A_ERYA1400

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fxj UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE

(Escherichia
coli) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		5 VAL A 314
ILE A 303
LEU A 266
ALA A 318
SER A 301
 VAL  A 314 ( 0.6A)
ILE  A 303 ( 0.7A)
LEU  A 266 ( 0.6A)
ALA  A 318 ( 0.0A)
SER  A 301 ( 0.0A)
 1.28A 4m83A-1fxjA:
undetectable		 4m83A-1fxjA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lzx NITRIC-OXIDE
SYNTHASE

(Rattus
norvegicus) 		PF02898
(NO_synthase) 		5 TRP A 561
TYR A 485
ASN A 476
LEU A 522
ALA A 512
 None
 1.50A 4m83A-1lzxA:
undetectable		 4m83A-1lzxA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1thg LIPASE 2

(Galactomyces
candidus) 		PF00135
(COesterase) 		5 PHE A 358
ASN A 350
LEU A 448
ALA A 420
SER A 402
 None
 1.35A 4m83A-1thgA:
undetectable		 4m83A-1thgA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vfn PURINE-NUCLEOSIDE
PHOSPHORYLASE

(Bos taurus) 		PF01048
(PNP_UDP_1) 		5 ASN A 151
VAL A 157
ILE A 226
ASN A 145
ALA A 161
 None
 1.49A 4m83A-1vfnA:
undetectable		 4m83A-1vfnA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vma CELL DIVISION
PROTEIN FTSY

(Thermotoga
maritima) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 HIS A 153
VAL A 203
ILE A 151
LEU A 139
ALA A 170
 None
 1.25A 4m83A-1vmaA:
undetectable		 4m83A-1vmaA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xjl ANNEXIN A2

(Homo sapiens) 		PF00191
(Annexin) 		5 VAL A  98
ILE A 291
TYR A 109
LEU A 315
SER A 296
 None
 1.44A 4m83A-1xjlA:
undetectable		 4m83A-1xjlA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 HIS A 964
VAL A 895
ILE A 962
LEU A 932
SER A 910
 None
 1.38A 4m83A-1zy4A:
undetectable		 4m83A-1zy4A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ajr SUGAR KINASE, PFKB
FAMILY

(Thermotoga
maritima) 		PF00294
(PfkB) 		5 HIS A 274
TYR A 310
LEU A  49
ALA A 287
SER A 288
 None
 1.42A 4m83A-2ajrA:
undetectable		 4m83A-2ajrA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5m DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1

(Homo sapiens) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		5 VAL A 866
ILE A 830
TYR A 891
LEU A 736
ALA A 882
 None
 1.28A 4m83A-2b5mA:
undetectable		 4m83A-2b5mA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bco SUCCINYLGLUTAMATE
DESUCCINYLASE

(Vibrio
parahaemolyticus) 		PF04952
(AstE_AspA) 		5 VAL A 137
PHE A 140
ILE A  56
LEU A 154
ALA A 213
 None
 1.48A 4m83A-2bcoA:
undetectable		 4m83A-2bcoA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ddx BETA-1,3-XYLANASE

(Vibrio sp. AX-4) 		no annotation 5 ASN A  80
ILE A  95
LEU A 111
ALA A  87
SER A 132
 None
 1.17A 4m83A-2ddxA:
undetectable		 4m83A-2ddxA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ep7 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Aquifex
aeolicus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 ASN A 135
VAL A 134
TYR A 269
LEU A 330
SER A 299
 None
 1.04A 4m83A-2ep7A:
undetectable		 4m83A-2ep7A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i62 NICOTINAMIDE
N-METHYLTRANSFERASE

(Mus musculus) 		PF01234
(NNMT_PNMT_TEMT) 		5 VAL A 222
ILE A 239
ASN A  45
LEU A  46
ALA A 199
 None
 1.25A 4m83A-2i62A:
undetectable		 4m83A-2i62A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuu DNA TRANSLOCASE FTSK

(Pseudomonas
aeruginosa) 		PF01580
(FtsK_SpoIIIE) 		5 ASN A 645
ILE A 624
TYR A 539
LEU A 456
ALA A 621
 None
 1.46A 4m83A-2iuuA:
undetectable		 4m83A-2iuuA:
22.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2iyf OLEANDOMYCIN
GLYCOSYLTRANSFERASE

(Streptomyces
antibioticus) 		PF00201
(UDPGT) 		11 HIS A  19
TRP A  73
ASN A  80
VAL A  81
PHE A  84
ILE A 111
TYR A 114
ASN A 133
LEU A 134
ALA A 182
SER A 183
 ERY  A1400 (-3.9A)
ERY  A1400 (-3.8A)
ERY  A1400 (-3.7A)
ERY  A1400 (-4.6A)
ERY  A1400 ( 3.8A)
ERY  A1400 ( 3.8A)
None
ERY  A1400 (-3.6A)
ERY  A1400 ( 4.8A)
ERY  A1400 (-3.6A)
ERY  A1400 (-2.8A)
 0.05A 4m83A-2iyfA:
undetectable		 4m83A-2iyfA:
99.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1z RIBONUCLEOTIDE
REDUCTASE SUBUNIT R2

(Plasmodium
vivax) 		PF00268
(Ribonuc_red_sm) 		5 ASN A 250
VAL A 247
TYR A 236
ALA A 181
SER A 179
 None
 1.31A 4m83A-2o1zA:
undetectable		 4m83A-2o1zA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oi6 BIFUNCTIONAL PROTEIN
GLMU

(Escherichia
coli) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		5 VAL A 314
ILE A 303
LEU A 266
ALA A 318
SER A 301
 None
 1.26A 4m83A-2oi6A:
undetectable		 4m83A-2oi6A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po4 VIRION RNA
POLYMERASE

(Escherichia
virus N4) 		no annotation 5 TRP A 218
ASN A 148
PHE A  34
ILE A  12
ALA A  23
 None
 1.33A 4m83A-2po4A:
undetectable		 4m83A-2po4A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uyg 3-DEHYDROQUINATE
DEHYDRATASE

(Thermus
thermophilus) 		PF01220
(DHquinase_II) 		5 VAL A  95
ILE A   4
ASN A   6
LEU A  10
ALA A 134
 None
None
None
GOL  A1143 (-4.6A)
None
 1.42A 4m83A-2uygA:
undetectable		 4m83A-2uygA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3apo DNAJ HOMOLOG
SUBFAMILY C MEMBER
10

(Mus musculus) 		PF00085
(Thioredoxin)
PF00226
(DnaJ) 		5 ASN A 152
VAL A 151
PHE A 150
ASN A 217
ALA A 213
 None
 1.08A 4m83A-3apoA:
undetectable		 4m83A-3apoA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3apq DNAJ HOMOLOG
SUBFAMILY C MEMBER
10

(Mus musculus) 		PF00085
(Thioredoxin)
PF00226
(DnaJ) 		5 ASN A 152
VAL A 151
PHE A 150
ASN A 217
ALA A 213
 None
 1.11A 4m83A-3apqA:
undetectable		 4m83A-3apqA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3chx PMOA

(Methylosinus
trichosporium) 		PF02461
(AMO) 		5 PHE B  46
TYR B  42
ASN B 164
LEU B 160
ALA B  77
 None
 1.43A 4m83A-3chxB:
undetectable		 4m83A-3chxB:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e03 SHORT CHAIN
DEHYDROGENASE

(Xanthomonas
campestris) 		PF13561
(adh_short_C2) 		5 HIS A  52
ASN A  59
VAL A  58
ILE A  51
ALA A  15
 None
 1.28A 4m83A-3e03A:
undetectable		 4m83A-3e03A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3faw RETICULOCYTE BINDING
PROTEIN

(Streptococcus
agalactiae) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 ASN A 590
VAL A 589
TYR A 548
ASN A 479
ALA A 566
 None
 1.22A 4m83A-3fawA:
undetectable		 4m83A-3fawA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcr PUTATIVE
AMINOTRANSFERASE

(Ruegeria sp.
TM1040) 		PF00202
(Aminotran_3) 		5 VAL A 257
ILE A 286
LEU A 103
ALA A 122
SER A 300
 None
 1.34A 4m83A-3fcrA:
undetectable		 4m83A-3fcrA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3j L-LACTATE
DEHYDROGENASE 1

(Staphylococcus
aureus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ASN A   7
VAL A  31
ILE A 243
TYR A  21
ALA A 241
 None
 1.44A 4m83A-3h3jA:
undetectable		 4m83A-3h3jA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzs MONOFUNCTIONAL
GLYCOSYLTRANSFERASE

(Staphylococcus
aureus) 		PF00912
(Transgly) 		5 ASN A 224
VAL A 223
ILE A 231
LEU A 214
ALA A 192
 M0E  A 901 (-3.9A)
M0E  A 901 (-4.8A)
None
None
None
 1.29A 4m83A-3hzsA:
undetectable		 4m83A-3hzsA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i09 PERIPLASMIC
BRANCHED-CHAIN AMINO
ACID-BINDING PROTEIN

(Burkholderia
mallei) 		PF13458
(Peripla_BP_6) 		5 ASN A  77
ASN A 123
LEU A 131
ALA A  83
SER A 109
 None
 1.49A 4m83A-3i09A:
undetectable		 4m83A-3i09A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5q NUCLEOPORIN NUP170

(Saccharomyces
cerevisiae) 		no annotation 5 ASN B1441
ILE B1412
TYR B1399
LEU B1451
SER B1409
 None
 1.28A 4m83A-3i5qB:
undetectable		 4m83A-3i5qB:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1t GLUTAMATE--CYSTEINE
LIGASE GSHA

(Methylobacillus
flagellatus) 		PF08886
(GshA) 		5 TRP A 202
ASN A 177
PHE A  64
ILE A 195
TYR A  44
 None
None
GOL  A 438 (-4.8A)
None
None
 1.27A 4m83A-3k1tA:
undetectable		 4m83A-3k1tA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyl TELOMERASE REVERSE
TRANSCRIPTASE

(Tribolium
castaneum) 		PF00078
(RVT_1)
PF12009
(Telomerase_RBD) 		5 HIS A  87
VAL A 491
ILE A 426
LEU A 419
ALA A 432
 None
 1.38A 4m83A-3kylA:
undetectable		 4m83A-3kylA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pih UVRABC SYSTEM
PROTEIN A

(Thermotoga
maritima) 		PF00005
(ABC_tran) 		5 VAL A 611
ILE A 658
TYR A 587
LEU A 631
ALA A 588
 None
 1.45A 4m83A-3pihA:
undetectable		 4m83A-3pihA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sok FIMBRIAL PROTEIN

(Dichelobacter
nodosus) 		PF00114
(Pilin)
PF07963
(N_methyl) 		5 ASN A 134
VAL A 122
ILE A  47
ASN A  95
ALA A  40
 None
 1.46A 4m83A-3sokA:
undetectable		 4m83A-3sokA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3teb ENDONUCLEASE/EXONUCL
EASE/PHOSPHATASE

(Leptotrichia
buccalis) 		PF03372
(Exo_endo_phos) 		5 HIS A 254
ASN A  41
VAL A  40
ALA A  36
SER A 138
 None
 1.49A 4m83A-3tebA:
undetectable		 4m83A-3tebA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vup BETA-1,4-MANNANASE

(Aplysia kurodai) 		PF00150
(Cellulase) 		5 ASN A 238
ILE A 200
TYR A 178
LEU A 159
ALA A 248
 SO4  A 402 ( 4.8A)
None
None
None
None
 1.42A 4m83A-3vupA:
undetectable		 4m83A-3vupA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1

(Mus musculus) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		5 ASN A 293
VAL A 290
ILE A 562
TYR A 552
ALA A 564
 None
 0.87A 4m83A-4b56A:
undetectable		 4m83A-4b56A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4di3 TATT (TP0956)

(Treponema
pallidum) 		PF16811
(TAtT) 		5 ASN A 278
VAL A 282
ASN A 204
LEU A 231
ALA A 267
 None
 1.12A 4m83A-4di3A:
undetectable		 4m83A-4di3A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dx3 MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME FAMILY
PROTEIN

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 VAL A 215
ILE A 264
LEU A 223
ALA A 262
SER A 260
 None
 1.31A 4m83A-4dx3A:
undetectable		 4m83A-4dx3A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jgp SPORULATION KINASE D

(Bacillus
subtilis) 		PF02743
(dCache_1) 		5 ASN A 233
VAL A 201
ILE A 189
LEU A  54
ALA A 210
 None
 1.44A 4m83A-4jgpA:
undetectable		 4m83A-4jgpA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nt9 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
pneumoniae) 		no annotation 5 HIS B  79
ASN B  59
VAL B  58
ASN B  77
ALA B  55
 None
 1.41A 4m83A-4nt9B:
undetectable		 4m83A-4nt9B:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pc4 30K LIPOPROTEIN

(Bombyx mori) 		PF03260
(Lipoprotein_11) 		5 ASN A  52
VAL A  49
TYR A  64
ALA A  30
SER A  21
 MES  A 302 (-3.3A)
None
None
None
None
 1.47A 4m83A-4pc4A:
undetectable		 4m83A-4pc4A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pc9 C4-DICARBOXYLATE
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN, PUTATIVE

(Roseobacter
denitrificans) 		PF03480
(DctP) 		5 ASN A 174
VAL A 175
ILE A 238
LEU A 215
ALA A 107
 None
CS2  A 401 (-4.6A)
CS2  A 401 (-4.9A)
CS2  A 401 (-4.2A)
None
 1.34A 4m83A-4pc9A:
undetectable		 4m83A-4pc9A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2c CRISPR-ASSOCIATED
HELICASE CAS3

(Thermobaculum
terrenum) 		PF00271
(Helicase_C) 		5 VAL A 763
TYR A 540
LEU A 519
ALA A 509
SER A 508
 None
 1.48A 4m83A-4q2cA:
undetectable		 4m83A-4q2cA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xg1 DIAMINOPIMELATE
DECARBOXYLASE

(Psychromonas
ingrahamii) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 HIS A  41
VAL A  68
TYR A  58
ASN A 282
ALA A  62
 None
None
None
None
LLP  A 508 ( 4.8A)
 1.44A 4m83A-4xg1A:
undetectable		 4m83A-4xg1A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzk TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE

(Streptomyces
blastmyceticus) 		PF11991
(Trp_DMAT) 		5 HIS A 324
ASN A 367
TYR A 348
ASN A 286
LEU A 282
 None
 1.35A 4m83A-4yzkA:
undetectable		 4m83A-4yzkA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7h IPT/TIG
DOMAIN-CONTAINING
PROTEIN BACOVA_02650

(Bacteroides
ovatus) 		PF01833
(TIG) 		5 HIS A 296
ASN A 317
VAL A 487
ASN A 264
SER A 239
 None
 1.36A 4m83A-5e7hA:
undetectable		 4m83A-5e7hA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eef HDAC6

(Danio rerio) 		PF00850
(Hist_deacetyl) 		5 VAL A 325
ILE A 342
LEU A 347
ALA A 374
SER A 375
 None
 1.28A 4m83A-5eefA:
undetectable		 4m83A-5eefA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7s GLYCOSIDE HYDROLASE
FAMILY 31

(Trueperella
pyogenes) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		5 HIS A 317
TRP A 304
ASN A 608
VAL A 609
ILE A 322
 None
 1.48A 4m83A-5f7sA:
undetectable		 4m83A-5f7sA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fc9 BLUE (TYPE 1) COPPER
DOMAIN PROTEIN

(Nitrosopumilus
maritimus) 		PF00127
(Copper-bind) 		5 VAL A1072
PHE A1073
ILE A1005
LEU A1063
ALA A1003
 None
 1.38A 4m83A-5fc9A:
undetectable		 4m83A-5fc9A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fqd DNA DAMAGE-BINDING
PROTEIN 1

(Homo sapiens) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		5 VAL A 866
ILE A 830
TYR A 891
LEU A 736
ALA A 882
 None
 1.30A 4m83A-5fqdA:
undetectable		 4m83A-5fqdA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5g PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT

(Escherichia
coli;
Escherichia
coli) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 HIS C 109
TYR C  52
ASN B 126
ALA C 127
SER C 128
 None
 1.16A 4m83A-5g5gC:
undetectable		 4m83A-5g5gC:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdh MALATE DEHYDROGENASE

(Sus scrofa) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 HIS A 186
VAL A 233
ASN A 130
LEU A 100
ALA A 242
 NAD  A 334 ( 3.7A)
None
MAK  A 335 ( 3.5A)
None
None
 1.37A 4m83A-5mdhA:
undetectable		 4m83A-5mdhA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szn PROTOCADHERIN GAMMA
A9

(Mus musculus) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		5 VAL A 130
TYR A 142
ASN A  99
ALA A 186
SER A 196
 None
None
CA  A 615 (-3.4A)
None
None
 1.29A 4m83A-5sznA:
undetectable		 4m83A-5sznA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t4m PROTOCADHERIN-15

(Homo sapiens) 		PF00028
(Cadherin) 		5 VAL A 513
TYR A 525
ASN A 482
ALA A 564
SER A 576
 None
None
CA  A 705 (-3.0A)
None
None
 1.46A 4m83A-5t4mA:
undetectable		 4m83A-5t4mA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1s SEPARIN

(Saccharomyces
cerevisiae) 		PF03568
(Peptidase_C50) 		5 HIS A 112
ASN A 137
ILE A 116
LEU A 127
ALA A 170
 None
 1.44A 4m83A-5u1sA:
undetectable		 4m83A-5u1sA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vdn GLUTATHIONE
OXIDOREDUCTASE

(Yersinia pestis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ASN A 302
ILE A 145
TYR A  17
LEU A 282
ALA A  19
 None
 1.49A 4m83A-5vdnA:
undetectable		 4m83A-5vdnA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1d PROTOCADHERIN-15

(Mus musculus) 		no annotation 5 VAL A 513
TYR A 525
ASN A 482
ALA A 564
SER A 576
 None
None
CA  A1005 (-3.0A)
None
None
 1.44A 4m83A-5w1dA:
undetectable		 4m83A-5w1dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wug BETA-GLUCOSIDASE

(Paenibacillus
barengoltzii) 		no annotation 5 ASN A  88
VAL A  89
ASN A 615
LEU A 612
ALA A  37
 None
 1.18A 4m83A-5wugA:
undetectable		 4m83A-5wugA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yyl -

(-) 		no annotation 5 VAL A  86
ILE A 121
TYR A 115
LEU A 127
SER A 123
 None
 1.19A 4m83A-5yylA:
undetectable		 4m83A-5yylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6avy ACYL-PROTEIN
THIOESTERASE 2

(Zea mays) 		no annotation 6 ASN A 153
VAL A 152
TYR A 144
LEU A 189
ALA A 104
SER A 135
 None
 1.44A 4m83A-6avyA:
undetectable		 4m83A-6avyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0m HEMAGGLUTININ-NEURAM
INIDASE

(Human
respirovirus 3) 		no annotation 5 ASN A 379
VAL A 378
TYR A 280
LEU A 268
ALA A 317
 None
None
None
None
CA  A 601 ( 4.9A)
 1.47A 4m83A-6c0mA:
undetectable		 4m83A-6c0mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c4g ASPARTIC PROTEASE
PM5

(Plasmodium
vivax) 		no annotation 5 ASN A 209
VAL A 164
TYR A  50
LEU A 193
ALA A 230
 None
 1.38A 4m83A-6c4gA:
undetectable		 4m83A-6c4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cgm RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Bacillus
subtilis) 		no annotation 5 ASN A 363
VAL A 364
ILE A 652
LEU A 656
SER A 383
 None
None
None
EDO  A 803 (-3.8A)
None
 1.41A 4m83A-6cgmA:
undetectable		 4m83A-6cgmA:
undetectable