SIMILAR PATTERNS OF AMINO ACIDS FOR 4M7K_H_ACTH302_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1a14 NC10 FV (HEAVY
CHAIN)

(Mus musculus) 		PF07686
(V-set) 		4 VAL H   2
TYR H  27
ARG H  94
TYR H 102
 None
 0.32A 4m7kH-1a14H:
22.7		 4m7kH-1a14H:
74.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1eap IGG2B-KAPPA 17E8 FAB
(HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL B   2
TYR B  27
ARG B  98
TYR B 113
 None
 0.44A 4m7kH-1eapB:
21.6		 4m7kH-1eapB:
65.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1egj ANTIBODY (HEAVY
CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL H   2
TYR H  27
ARG H  94
TYR H 102
 None
 0.34A 4m7kH-1egjH:
27.7		 4m7kH-1egjH:
66.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ehl ANTI-(6-4)
PHOTOPRODUCT
ANTIBODY 64M-2 FAB
(HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL H   2
TYR H  27
ARG H  94
TYR H 102
 None
 0.40A 4m7kH-1ehlH:
23.6		 4m7kH-1ehlH:
65.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1eo8 ANTIBODY (HEAVY
CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL H   2
TYR H  27
ARG H  94
TYR H 102
 None
 0.38A 4m7kH-1eo8H:
27.2		 4m7kH-1eo8H:
72.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1f4w ANTIBODY S-20-4, FAB
FRAGMENT, HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL H   2
TYR H  27
ARG H  98
TYR H 106
 None
 0.35A 4m7kH-1f4wH:
19.5		 4m7kH-1f4wH:
55.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jhl IGG1-KAPPA D11.15 FV
(HEAVY CHAIN)

(Mus musculus) 		PF07686
(V-set) 		4 VAL H   2
TYR H  27
ARG H  98
TYR H 107
 None
 0.41A 4m7kH-1jhlH:
22.8		 4m7kH-1jhlH:
72.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jnh MONOCLONAL
ANTI-ESTRADIOL
10G6D6 FAB HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL B   2
TYR B  27
ARG B  98
TYR B 108
 None
 0.43A 4m7kH-1jnhB:
25.4		 4m7kH-1jnhB:
64.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kb5 ANTIBODY DESIRE-1

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL H   2
TYR H  27
ARG H  94
TYR H 102
 None
 0.36A 4m7kH-1kb5H:
27.0		 4m7kH-1kb5H:
66.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lk3 9D7 HEAVY CHAIN

(Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL H   2
TYR H  27
ARG H  98
TYR H 108
 None
 0.29A 4m7kH-1lk3H:
26.8		 4m7kH-1lk3H:
67.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lmk ANTI-PHOSPHATIDYLINO
SITOL SPECIFIC
PHOSPHOLIPASE C
DIABODY

(Mus musculus) 		PF07686
(V-set) 		4 VAL A   2
TYR A  27
ARG A  98
TYR A 111
 None
 0.40A 4m7kH-1lmkA:
22.6		 4m7kH-1lmkA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mfa IGG1-LAMBDA SE155-4
FAB (HEAVY CHAIN)

(Mus musculus) 		PF07686
(V-set) 		4 VAL H 252
TYR H 277
ARG H 348
TYR H 357
 None
 0.41A 4m7kH-1mfaH:
22.6		 4m7kH-1mfaH:
62.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n4x IMMUNOGLOBULIN HEAVY
CHAIN VARIABLE
REGION

(Mus musculus) 		PF07686
(V-set) 		4 VAL H 302
TYR H 327
ARG H 398
TYR H 409
 None
 0.16A 4m7kH-1n4xH:
22.0		 4m7kH-1n4xH:
49.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n7m GERMLINE METAL
CHELATASE CATALYTIC
ANTIBODY, CHAIN L

(Homo sapiens;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL L   2
TYR L  27
ARG L  98
TYR L 103
 None
 0.19A 4m7kH-1n7mL:
22.5		 4m7kH-1n7mL:
83.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ngq N1G9 (IGG1-LAMBDA)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL H   2
TYR H  27
ARG H  98
TYR H 109
 None
 0.33A 4m7kH-1ngqH:
22.5		 4m7kH-1ngqH:
69.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nqb SINGLE-CHAIN
ANTIBODY FRAGMENT

(Mus musculus) 		PF07686
(V-set) 		4 VAL A   2
TYR A  27
ARG A  98
TYR A 109
 None
 0.28A 4m7kH-1nqbA:
22.3		 4m7kH-1nqbA:
49.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pg7 MURINE ANTIBODY 6A6
FAB FRAGMENT

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL X   2
TYR X  27
ARG X  94
TYR X 102
 None
 0.40A 4m7kH-1pg7X:
22.7		 4m7kH-1pg7X:
62.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q0y FAB 9B1, HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL H   2
TYR H  27
ARG H  94
TYR H 102
 None
 0.38A 4m7kH-1q0yH:
24.3		 4m7kH-1q0yH:
71.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qfu PROTEIN
(IMMUNOGLOBULIN
IGG1-KAPPA ANTIBODY
(HEAVY CHAIN))

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL H   2
TYR H  27
ARG H  94
TYR H 102
 None
 0.41A 4m7kH-1qfuH:
25.9		 4m7kH-1qfuH:
64.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rih HEAVY CHAIN OF
ANTIBODY 14F7

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL H   2
TYR H  27
ARG H  94
TYR H 102
 None
 0.17A 4m7kH-1rihH:
23.1		 4m7kH-1rihH:
62.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rmf IGG2A-KAPPA R6.5 FAB
(HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL H   2
TYR H  27
ARG H  98
TYR H 108
 None
 0.36A 4m7kH-1rmfH:
20.0		 4m7kH-1rmfH:
64.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rur IMMUNOGLOBULIN 13G5,
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL H   2
TYR H  27
ARG H  94
TYR H 102
 None
 0.23A 4m7kH-1rurH:
28.2		 4m7kH-1rurH:
68.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svz SINGLE-CHAIN FV
FRAGMENT 1696

(Mus musculus) 		PF07686
(V-set) 		4 VAL A 129
TYR A 154
ARG A 225
TYR A 236
 None
 0.38A 4m7kH-1svzA:
15.6		 4m7kH-1svzA:
22.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sy6 OKT3 FAB HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL H   2
TYR H  27
ARG H  98
TYR H 108
 None
 0.38A 4m7kH-1sy6H:
27.7		 4m7kH-1sy6H:
67.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1yed IGG1 FAB FRAGMENT
(D.2.4)

(Mus musculus) 		no annotation 4 VAL H   2
TYR H  27
ARG H  94
TYR H 102
 None
 0.41A 4m7kH-1yedH:
26.8		 4m7kH-1yedH:
64.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1yee IGG2A FAB FRAGMENT
(D2.5)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL H   2
TYR H  27
ARG H  94
TYR H 102
 None
 0.35A 4m7kH-1yeeH:
26.3		 4m7kH-1yeeH:
65.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2g60 ANTI-FLAG M2 FAB
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL H   2
TYR H  27
ARG H  94
TYR H 102
 None
 0.32A 4m7kH-2g60H:
27.7		 4m7kH-2g60H:
63.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ok0 FAB ED10 HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL H   2
TYR H  27
ARG H  94
TYR H 102
 None
 0.40A 4m7kH-2ok0H:
21.8		 4m7kH-2ok0H:
64.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2op4 MURINE ANTIBODY FAB
RS2-1G9 IGG1 HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL H   2
TYR H  27
ARG H  94
TYR H 102
 None
 0.26A 4m7kH-2op4H:
22.9		 4m7kH-2op4H:
70.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xqy A13-D6.3 MONOCLONAL
ANTIBODY

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL G   2
TYR G  27
ARG G  94
TYR G 102
 None
 0.21A 4m7kH-2xqyG:
27.8		 4m7kH-2xqyG:
56.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zch MONOCLONAL ANTIBODY
8G8F5 FAB

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL H   2
TYR H  27
ARG H  94
TYR H 102
 None
 0.30A 4m7kH-2zchH:
26.7		 4m7kH-2zchH:
64.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zjs FAB56 (HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL H   2
TYR H  27
ARG H  98
TYR H 108
 None
 0.30A 4m7kH-2zjsH:
23.1		 4m7kH-2zjsH:
75.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3bqu 3H6 FAB HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL D   2
TYR D  27
ARG D  98
TYR D 111
 None
None
SO4  D 225 (-3.0A)
None
 0.31A 4m7kH-3bquD:
27.3		 4m7kH-3bquD:
62.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3cvh 25-D1.16 HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL H   1
TYR H  26
ARG H  97
TYR H 109
 None
 0.25A 4m7kH-3cvhH:
22.2		 4m7kH-3cvhH:
68.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3eo9 EFALIZUMAB FAB
FRAGMENT, HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL H   2
TYR H  27
ARG H  98
TYR H 110
 None
 0.44A 4m7kH-3eo9H:
21.7		 4m7kH-3eo9H:
75.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3h3b ANTI-ERBB2 ANTIBODY
CHA21

(Mus musculus) 		PF07686
(V-set) 		4 VAL C 136
TYR C 161
ARG C 232
TYR C 243
 None
 0.34A 4m7kH-3h3bC:
15.1		 4m7kH-3h3bC:
63.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hc4 IMMUNOGLOBULIN IGG1
FAB, HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL H   2
TYR H  27
ARG H  98
TYR H 105
 None
 0.20A 4m7kH-3hc4H:
26.1		 4m7kH-3hc4H:
80.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hns CS-35 FAB HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL H   2
TYR H  27
ARG H  98
TYR H 107
 None
 0.15A 4m7kH-3hnsH:
28.1		 4m7kH-3hnsH:
64.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3i75 ANTIBODY LIGHT CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL B   2
TYR B  27
ARG B  98
TYR B 114
 None
 0.44A 4m7kH-3i75B:
27.3		 4m7kH-3i75B:
64.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3iy0 FAB 14, HEAVY DOMAIN

(Mus musculus) 		PF07686
(V-set) 		4 VAL H   2
TYR H  27
ARG H  98
TYR H 109
 None
 0.39A 4m7kH-3iy0H:
22.9		 4m7kH-3iy0H:
53.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3j93 NEUTRALIZING
ANTIBODY 22A12,
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL H   2
TYR H  27
ARG H  97
TYR H 108
 None
 0.39A 4m7kH-3j93H:
16.6		 4m7kH-3j93H:
65.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mxw 5E1 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL H   2
TYR H  27
ARG H  94
TYR H 102
 None
 0.33A 4m7kH-3mxwH:
30.0		 4m7kH-3mxwH:
81.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nn8 ENGINEERED SCFV,
HEAVY CHAIN

(Mus musculus) 		PF07686
(V-set) 		4 VAL A   2
TYR A  27
ARG A  99
TYR A 111
 None
 0.31A 4m7kH-3nn8A:
20.5		 4m7kH-3nn8A:
57.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nz8 MOUSE ANTI V3
ANTIBODY 7C8 FAB,
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL A   2
TYR A  27
ARG A  94
TYR A 102
 None
 0.28A 4m7kH-3nz8A:
27.9		 4m7kH-3nz8A:
67.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3oz9 FAB NC-1 IGG2A HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL H   2
TYR H  27
ARG H  94
TYR H 102
 None
 0.35A 4m7kH-3oz9H:
27.8		 4m7kH-3oz9H:
75.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qpq C1068 HEAVY CHAIN

(Homo sapiens;
Mus musculus) 		no annotation 4 VAL H   2
TYR H  27
ARG H  98
TYR H 108
 PCA  H   1 ( 3.4A)
None
None
None
 0.25A 4m7kH-3qpqH:
23.4		 4m7kH-3qpqH:
80.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ria MOUSE MONOCLONAL FAB
FRAGMENT, HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL F   2
TYR F  27
ARG F  98
TYR F 111
 None
 0.41A 4m7kH-3riaF:
23.2		 4m7kH-3riaF:
66.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3s35 6.64 FAB HEAVY CHAIN

(Homo sapiens;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL H   2
TYR H  27
ARG H  98
TYR H 106
 None
 0.31A 4m7kH-3s35H:
23.5		 4m7kH-3s35H:
65.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt1 MOUSE MONOCLONAL
1GG2A FAB FRAGMENT,
KAPPA LIGHT CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL H   2
TYR H  27
ARG H  98
TYR H 110
 None
 0.28A 4m7kH-3tt1H:
26.1		 4m7kH-3tt1H:
67.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uji FAB REGION OF THE
HEAVY CHAIN OF
ANTI-HIV-1 V3
MONOCLONAL ANTIBODY
2558

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL H   2
TYR H  27
ARG H  94
TYR H 102
 None
 0.28A 4m7kH-3ujiH:
22.3		 4m7kH-3ujiH:
74.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ag4 MONOCLONAL ANTIBODY
3E3 HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL H   2
TYR H  27
ARG H  94
TYR H 102
 None
 0.29A 4m7kH-4ag4H:
26.9		 4m7kH-4ag4H:
69.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ala FAB 2H12 HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL H   2
TYR H  27
ARG H  98
TYR H 106
 None
 0.28A 4m7kH-4alaH:
24.9		 4m7kH-4alaH:
66.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bz1 FAB 3E31 HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL H   2
TYR H  27
ARG H  98
TYR H 106
 None
 0.19A 4m7kH-4bz1H:
26.9		 4m7kH-4bz1H:
69.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4cmh HEAVY CHAIN OF
SAR650984-FAB
FRAGMENT

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL B   2
TYR B  27
ARG B  98
TYR B 109
 None
 0.18A 4m7kH-4cmhB:
26.1		 4m7kH-4cmhB:
82.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f33 MORAB-009 FAB HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL B   2
TYR B  27
ARG B  98
TYR B 108
 PCA  B   1 ( 3.3A)
None
None
None
 0.21A 4m7kH-4f33B:
30.4		 4m7kH-4f33B:
81.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4h20 HEAVY CHAIN OF FAB
FRAGMENT FROM THE
ANTI-RICIN
MONOCLONAL ANTIBODY
RAC18

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL H   2
TYR H  27
ARG H  98
TYR H 108
 None
 0.34A 4m7kH-4h20H:
15.7		 4m7kH-4h20H:
66.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hwe FAB HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL H   3
TYR H  28
ARG H  99
TYR H 108
 None
 0.28A 4m7kH-4hweH:
22.0		 4m7kH-4hweH:
77.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4kuz ANTIBODY 4A5 HEAVY
CHAIN

(Homo sapiens;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL H   2
TYR H  27
ARG H  98
TYR H 109
 None
 0.38A 4m7kH-4kuzH:
29.2		 4m7kH-4kuzH:
83.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4m43 FRAGMENT
ANTIGEN-BINDING
523-11 HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL H   2
TYR H  27
ARG H  94
TYR H 102
 None
 0.24A 4m7kH-4m43H:
22.5		 4m7kH-4m43H:
68.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mxv ANTI-LYMPHOTOXIN
ALPHA ANTIBODY HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL F   2
TYR F  27
ARG F  94
TYR F 102
 None
 0.37A 4m7kH-4mxvF:
28.0		 4m7kH-4mxvF:
74.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n8c HEAVY CHAIN OF
MONOCLONAL ANTIBODY

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL H   2
TYR H  27
ARG H  98
TYR H 108
 None
 0.36A 4m7kH-4n8cH:
23.0		 4m7kH-4n8cH:
63.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nm4 ANTIBODY CR8043,
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL H   2
TYR H  27
ARG H  94
TYR H 102
 None
 0.22A 4m7kH-4nm4H:
21.9		 4m7kH-4nm4H:
76.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4pb9 AB64 HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL H   2
TYR H  27
ARG H  94
TYR H 102
 None
 0.43A 4m7kH-4pb9H:
26.8		 4m7kH-4pb9H:
64.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4q6i HEAVY CHAIN OF
MURINE 2D5 FAB

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL B   2
TYR B  27
ARG B  94
TYR B 102
 None
 0.38A 4m7kH-4q6iB:
24.6		 4m7kH-4q6iB:
57.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r96 LLAMA GLAMA FAB 48A2
AGAINST HUMAN CMET H
CHAIN

(Lama glama) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL B   2
TYR B  27
ARG B  98
TYR B 108
 None
 0.42A 4m7kH-4r96B:
27.8		 4m7kH-4r96B:
78.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4u6h HEAVY CHAIN OF
MURINE ANTI-VACCINIA
L1 IGG2A ANTIBODY
M12B9

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL A   2
TYR A  27
ARG A  98
TYR A 108
 None
 0.28A 4m7kH-4u6hA:
27.2		 4m7kH-4u6hA:
66.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ut9 BROADLY NEUTRALIZING
HUMAN ANTIBODY EDE1
C10

(Homo sapiens) 		PF07686
(V-set) 		4 VAL H   2
TYR H  27
ARG H  94
TYR H 102
 None
 0.42A 4m7kH-4ut9H:
21.5		 4m7kH-4ut9H:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4x0k FAB FRAGMENT HEAVY
CHAIN

(Homo sapiens) 		no annotation 4 VAL H   2
TYR H  27
ARG H  94
TYR H 102
 None
 0.30A 4m7kH-4x0kH:
22.4		 4m7kH-4x0kH:
75.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4zso ANTIBODY HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL B   2
TYR B  27
ARG B  98
TYR B 110
 None
 0.21A 4m7kH-4zsoB:
23.5		 4m7kH-4zsoB:
68.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a3i ANTI-HAEMAGGLUTININ
HA1 FAB HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL C   2
TYR C  27
ARG C  98
TYR C 114
 None
 0.31A 4m7kH-5a3iC:
25.1		 4m7kH-5a3iC:
74.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5cma ANTIBODY CH8H9 FAB
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL B   2
TYR B  27
ARG B  98
TYR B 107
 None
 0.31A 4m7kH-5cmaB:
29.2		 4m7kH-5cmaB:
86.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5d93 HEAVY CHAIN OF FAB
FRAGMENT FROM A
MOUSE QSOX1-SPECIFIC
ANTIBODY

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL C   2
TYR C  27
ARG C  98
TYR C 105
 None
 0.23A 4m7kH-5d93C:
25.9		 4m7kH-5d93C:
87.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dk3 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL B   2
TYR B  27
ARG B  98
TYR B 109
 None
 0.40A 4m7kH-5dk3B:
23.4		 4m7kH-5dk3B:
39.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f9w HEAVY CHAIN OF
CH235-LINEAGE
ANTIBODY CH235

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL B   2
TYR B  27
ARG B  94
TYR B 102
 None
 0.43A 4m7kH-5f9wB:
23.0		 4m7kH-5f9wB:
76.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i0z CATALYTIC DNA
ANTIBODY

(Mus musculus) 		PF07686
(V-set) 		4 VAL A  24
TYR A  49
ARG A 120
TYR A 131
 None
 0.24A 4m7kH-5i0zA:
23.6		 4m7kH-5i0zA:
69.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i73 8B6 ANTIBODY, HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL B  21
TYR B  46
ARG B 117
TYR B 127
 None
 0.26A 4m7kH-5i73B:
26.6		 4m7kH-5i73B:
65.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5iwl 5F9 DIABODY

(Homo sapiens) 		no annotation 4 VAL B   2
TYR B  27
ARG B  98
TYR B 106
 PCA  B   1 ( 3.3A)
None
None
None
 0.33A 4m7kH-5iwlB:
22.1		 4m7kH-5iwlB:
43.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jxa VRC03 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL H   2
TYR H  27
ARG H  94
TYR H 102
 None
 0.30A 4m7kH-5jxaH:
21.1		 4m7kH-5jxaH:
68.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jyl SCFV TSP7

(Mus musculus) 		PF07686
(V-set) 		4 VAL B   2
TYR B  27
ARG B  98
TYR B 108
 None
None
None
CL  B 303 (-4.9A)
 0.30A 4m7kH-5jylB:
23.5		 4m7kH-5jylB:
47.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jym ANTIBODY SCFV TSP11

(Mus musculus) 		PF07686
(V-set) 		4 VAL B   2
TYR B  27
ARG B  98
TYR B 111
 None
 0.34A 4m7kH-5jymB:
22.2		 4m7kH-5jymB:
49.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5kn5 EPIREGULIN ANTIBODY
LY3016859 FAB HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL A   2
TYR A  27
ARG A  98
TYR A 107
 SO4  A 301 (-3.9A)
None
None
SO4  A 301 (-4.1A)
 0.22A 4m7kH-5kn5A:
22.7		 4m7kH-5kn5A:
77.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5kvd ZV-2 ANTIBODY FAB
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL H   2
TYR H  27
ARG H  94
TYR H 102
 PCA  H   1 ( 3.3A)
None
None
None
 0.27A 4m7kH-5kvdH:
23.1		 4m7kH-5kvdH:
71.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l7x MOUSE ANTIBODY FAB
FRAGMENT, IGG1-KAPPA
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL H   2
TYR H  27
ARG H  94
TYR H 102
 None
 0.31A 4m7kH-5l7xH:
26.1		 4m7kH-5l7xH:
65.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lwy V REGION HEAVY CHAIN

(Mus musculus) 		PF07686
(V-set) 		4 VAL H   2
TYR H  27
ARG H  98
TYR H 107
 None
 0.28A 4m7kH-5lwyH:
23.1		 4m7kH-5lwyH:
69.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lx9 SINGLE-CHAIN
VARIABLE FRAGMENT

(Mus musculus) 		PF07686
(V-set) 		4 VAL H   2
TYR H  27
ARG H  98
TYR H 107
 None
 0.29A 4m7kH-5lx9H:
22.8		 4m7kH-5lx9H:
41.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5myx FAB C#24 HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL B   2
TYR B  27
ARG B  98
TYR B 104
 PCA  B   1 ( 3.3A)
None
None
None
 0.20A 4m7kH-5myxB:
28.5		 4m7kH-5myxB:
63.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ngv ANTI-HUMAN ACTRIIB
MAB BYM338
HEAVY-CHAIN

(Homo sapiens) 		no annotation 4 VAL H   2
TYR H  27
ARG H  98
TYR H 104
 PCA  H   1 ( 3.4A)
None
None
None
 0.32A 4m7kH-5ngvH:
22.3		 4m7kH-5ngvH:
36.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5nph HEAVY CHAIN OF FAB
FRAGMENT DERIVED
FROM
NON-NEUTRALIZING
ANTIBODY DAO5

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL H   2
TYR H  27
ARG H  98
TYR H 109
 None
 0.42A 4m7kH-5nphH:
22.9		 4m7kH-5nphH:
53.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5nuz EOD01 HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL A   2
TYR A  27
ARG A  94
TYR A 102
 None
 0.26A 4m7kH-5nuzA:
24.0		 4m7kH-5nuzA:
65.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5x 3C10 FAB' HEAVY
CHAIN

(Rattus
norvegicus) 		no annotation 4 VAL H   2
TYR H  27
ARG H  98
TYR H 107
 PCA  H   1 ( 3.3A)
None
None
None
 0.34A 4m7kH-5w5xH:
23.8		 4m7kH-5w5xH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ywf 2H4 HEAVY CHAIN

(Mus musculus) 		no annotation 4 VAL B   2
TYR B  27
ARG B  98
TYR B 107
 None
 0.30A 4m7kH-5ywfB:
22.5		 4m7kH-5ywfB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ani COLTUXIMAB FAB HEAVY
CHAIN

(Homo sapiens) 		no annotation 4 VAL H   2
TYR H  27
ARG H  94
TYR H 102
 None
 0.26A 4m7kH-6aniH:
23.4		 4m7kH-6aniH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aq7 POM6 FAB HEAVY CHAIN

(Mus musculus) 		no annotation 4 VAL H   1
TYR H  26
ARG H  97
TYR H 104
 None
 0.21A 4m7kH-6aq7H:
27.7		 4m7kH-6aq7H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bb4 MOUSE MONOCLONAL
ANTIBODY C5.2 FAB
HEAVY CHAIN

(Mus musculus) 		no annotation 4 VAL H   2
TYR H  27
ARG H  94
TYR H 102
 None
 0.31A 4m7kH-6bb4H:
27.2		 4m7kH-6bb4H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cuf -

(-) 		no annotation 4 VAL 8   2
TYR 8  27
ARG 8  94
TYR 8 102
 None
 0.42A 4m7kH-6cuf8:
20.1		 4m7kH-6cuf8:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6db7 HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 1334 FAB
HEAVY CHAIN

(Homo sapiens) 		no annotation 4 VAL H   2
TYR H  27
ARG H  94
TYR H 102
 None
 0.34A 4m7kH-6db7H:
28.0		 4m7kH-6db7H:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6ehx SCFV ABVANCE:
INCREASING OUR
KNOWLEDGE OF
ANTIBODY STRUCTURAL
SPACE TO ENABLE
FASTER AND BETTER
DECISION MAKING IN
DRUG DISCOVERY

(Homo sapiens) 		no annotation 4 VAL B   2
TYR B  27
ARG B  98
TYR B 110
 None
 0.28A 4m7kH-6ehxB:
20.9		 4m7kH-6ehxB:
42.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6ehy SCFV ANTIBODY
FRAGMENT

(Homo sapiens) 		no annotation 4 VAL A   2
TYR A  27
ARG A  98
TYR A 110
 None
 0.28A 4m7kH-6ehyA:
21.4		 4m7kH-6ehyA:
42.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ffj -

(-) 		no annotation 4 VAL A   2
TYR A  27
ARG A  98
TYR A 114
 None
 0.38A 4m7kH-6ffjA:
21.6		 4m7kH-6ffjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6h0e -

(-) 		no annotation 4 VAL H   2
TYR H  27
ARG H  98
TYR H 110
 PCA  H   1 ( 3.3A)
None
None
None
 0.23A 4m7kH-6h0eH:
22.1		 4m7kH-6h0eH:
undetectable