SIMILAR PATTERNS OF AMINO ACIDS FOR 4M6T_A_SAMA201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bdy PROTEIN KINASE C

(Rattus
norvegicus) 		no annotation 4 ILE A  63
VAL A  90
VAL A  88
ARG A  67
 None
 1.05A 4m6tA-1bdyA:
undetectable		 4m6tA-1bdyA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e59 PHOSPHOGLYCERATE
MUTASE

(Escherichia
coli) 		PF00300
(His_Phos_1) 		4 ILE A 168
VAL A   6
VAL A 178
ARG A 171
 None
 1.10A 4m6tA-1e59A:
undetectable		 4m6tA-1e59A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1epx FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE

(Leishmania
mexicana) 		PF00274
(Glycolytic) 		4 ILE A 296
VAL A 243
VAL A 263
ARG A 303
 None
 1.36A 4m6tA-1epxA:
0.0		 4m6tA-1epxA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyq PROTEIN
(GLYCERALDEHYDE-3-PH
OSPHATE
DEHYDROGENASE)

(Leishmania
mexicana) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 ILE A   3
VAL A 107
VAL A 347
ARG A 348
 None
 1.36A 4m6tA-1gyqA:
0.0		 4m6tA-1gyqA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iho PANTOATE--BETA-ALANI
NE LIGASE

(Escherichia
coli) 		PF02569
(Pantoate_ligase) 		4 ILE A  14
VAL A  51
VAL A  24
ARG A  18
 None
 1.20A 4m6tA-1ihoA:
undetectable		 4m6tA-1ihoA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jfr LIPASE

(Streptomyces
exfoliatus) 		PF03403
(PAF-AH_p_II) 		4 ILE A  43
VAL A  57
VAL A  83
ARG A 119
 None
 1.17A 4m6tA-1jfrA:
0.0		 4m6tA-1jfrA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2w MANNITOL
DEHYDROGENASE

(Pseudomonas
fluorescens) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		4 ILE A 102
VAL A  63
VAL A  34
ARG A  39
 None
None
NAD  A5500 (-4.8A)
None
 1.08A 4m6tA-1m2wA:
0.0		 4m6tA-1m2wA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qxo CHORISMATE SYNTHASE

(Streptococcus
pneumoniae) 		PF01264
(Chorismate_synt) 		4 ILE A 180
VAL A 161
VAL A 192
ARG A 183
 None
 1.09A 4m6tA-1qxoA:
0.0		 4m6tA-1qxoA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6m RIBONUCLEASE PH

(Pseudomonas
aeruginosa) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		4 ILE A  17
VAL A  38
VAL A  29
ARG A  19
 None
 0.97A 4m6tA-1r6mA:
0.0		 4m6tA-1r6mA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlu GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE

(Saccharomyces
cerevisiae) 		PF00171
(Aldedh) 		4 ILE A 137
VAL A 177
VAL A 175
ARG A  26
 None
 1.18A 4m6tA-1vluA:
undetectable		 4m6tA-1vluA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w78 FOLC BIFUNCTIONAL
PROTEIN

(Escherichia
coli) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 ILE A 209
VAL A 165
VAL A 200
ARG A 222
 None
 1.22A 4m6tA-1w78A:
undetectable		 4m6tA-1w78A:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z48 PROBABLE
NADH-DEPENDENT
FLAVIN
OXIDOREDUCTASE YQJM

(Bacillus
subtilis) 		PF00724
(Oxidored_FMN) 		4 ILE A 295
VAL A 283
VAL A 266
ARG A 300
 None
FMN  A1500 (-4.5A)
None
None
 1.02A 4m6tA-1z48A:
undetectable		 4m6tA-1z48A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwp 5-AMINOLEVULINATE
SYNTHASE

(Rhodobacter
capsulatus) 		PF00155
(Aminotran_1_2) 		4 ILE A  26
VAL A 356
VAL A  50
ARG A  28
 None
 0.98A 4m6tA-2bwpA:
undetectable		 4m6tA-2bwpA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dh3 4F2 CELL-SURFACE
ANTIGEN HEAVY CHAIN

(Homo sapiens) 		PF00128
(Alpha-amylase) 		4 ILE A 276
VAL A 203
VAL A 159
ARG A 125
 None
 1.25A 4m6tA-2dh3A:
undetectable		 4m6tA-2dh3A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dyk GTP-BINDING PROTEIN

(Thermus
thermophilus) 		PF01926
(MMR_HSR1) 		4 ILE A 156
VAL A   5
VAL A  82
ARG A 159
 None
 1.36A 4m6tA-2dykA:
undetectable		 4m6tA-2dykA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hur NUCLEOSIDE
DIPHOSPHATE KINASE

(Escherichia
coli) 		PF00334
(NDK) 		4 ILE A 129
VAL A  74
VAL A  76
ARG A   5
 None
 1.34A 4m6tA-2hurA:
undetectable		 4m6tA-2hurA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jf3 ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE

(Escherichia
coli) 		PF00132
(Hexapep)
PF13720
(Acetyltransf_11) 		4 ILE A 215
VAL A 169
VAL A 197
ARG A 216
 None
 1.00A 4m6tA-2jf3A:
undetectable		 4m6tA-2jf3A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdw VACCINIA VIRUS
CAPPING ENZYME D1
SUBUNIT

(Vaccinia virus) 		PF03291
(Pox_MCEL) 		4 ILE A 613
VAL A 617
VAL A 594
ARG A 592
 None
 1.25A 4m6tA-2vdwA:
undetectable		 4m6tA-2vdwA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vld UPF0286 PROTEIN
PYRAB01260

(Pyrococcus
abyssi) 		PF01939
(NucS) 		4 ILE A 134
VAL A 172
VAL A 161
ARG A 150
 None
 1.29A 4m6tA-2vldA:
undetectable		 4m6tA-2vldA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus musculus) 		PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC)
PF12047
(DNMT1-RFD) 		4 ILE A1416
VAL A1550
VAL A1552
ARG A1574
 None
 1.19A 4m6tA-3av6A:
undetectable		 4m6tA-3av6A:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus musculus) 		PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC)
PF12047
(DNMT1-RFD) 		4 ILE A1571
VAL A1550
VAL A1552
ARG A1574
 None
 1.10A 4m6tA-3av6A:
undetectable		 4m6tA-3av6A:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aw5 MULTICOPPER OXIDASE

(Pyrobaculum
aerophilum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ILE A 173
VAL A 206
VAL A 201
ARG A 229
 None
 1.35A 4m6tA-3aw5A:
undetectable		 4m6tA-3aw5A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b4t RIBONUCLEASE PH

(Mycobacterium
tuberculosis) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		4 ILE A  17
VAL A  38
VAL A  29
ARG A  19
 None
 1.05A 4m6tA-3b4tA:
undetectable		 4m6tA-3b4tA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b4u DIHYDRODIPICOLINATE
SYNTHASE

(Agrobacterium
fabrum) 		PF00701
(DHDPS) 		4 ILE A 273
VAL A 250
VAL A 252
ARG A 278
 None
 1.09A 4m6tA-3b4uA:
undetectable		 4m6tA-3b4uA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bif PROTEIN
(6-PHOSPHOFRUCTO-2-K
INASE/
FRUCTOSE-2,6-BISPHOS
PHATASE)

(Rattus
norvegicus) 		PF00300
(His_Phos_1)
PF01591
(6PF2K) 		4 ILE A 140
VAL A 126
VAL A  42
ARG A 137
 BOG  A 510 (-4.5A)
None
None
None
 1.35A 4m6tA-3bifA:
undetectable		 4m6tA-3bifA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3co5 PUTATIVE
TWO-COMPONENT SYSTEM
TRANSCRIPTIONAL
RESPONSE REGULATOR

(Neisseria
gonorrhoeae) 		PF14532
(Sigma54_activ_2) 		4 ILE A 239
VAL A 184
VAL A 207
ARG A 237
 None
 1.33A 4m6tA-3co5A:
undetectable		 4m6tA-3co5A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e8j COPROPORPHYRINOGEN
III OXIDASE

(Leishmania
naiffi) 		PF01218
(Coprogen_oxidas) 		4 ILE A  19
VAL A  95
VAL A  61
ARG A  48
 None
ACT  A 302 (-4.7A)
None
None
 1.11A 4m6tA-3e8jA:
undetectable		 4m6tA-3e8jA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3exh PYRUVATE
DEHYDROGENASE E1
COMPONENT SUBUNIT
BETA, MITOCHONDRIAL

(Homo sapiens) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 ILE B 241
VAL B 169
VAL B 144
ARG B 242
 None
 1.16A 4m6tA-3exhB:
undetectable		 4m6tA-3exhB:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f5f MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HEPARAN SULFATE
2-O-SULFOTRANSFERASE
1

(Escherichia
coli;
Gallus gallus) 		PF03567
(Sulfotransfer_2)
PF13416
(SBP_bac_8) 		4 ILE A 116
VAL A 246
VAL A 244
ARG A 316
 None
 1.38A 4m6tA-3f5fA:
undetectable		 4m6tA-3f5fA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fq4 INTEGRIN BETA-4

(Homo sapiens) 		PF03160
(Calx-beta) 		4 ILE A1102
VAL A1007
VAL A1001
ARG A1103
 None
 1.24A 4m6tA-3fq4A:
undetectable		 4m6tA-3fq4A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fq6 METHYLTRANSFERASE

(Bacteroides
thetaiotaomicron) 		PF00590
(TP_methylase) 		4 ILE A 215
VAL A 218
VAL A 183
ARG A 185
 None
 1.18A 4m6tA-3fq6A:
undetectable		 4m6tA-3fq6A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gr8 NADPH DEHYDROGENASE

(Geobacillus
kaustophilus) 		PF00724
(Oxidored_FMN) 		4 ILE A 295
VAL A 283
VAL A 266
ARG A 300
 None
FMN  A 341 (-4.5A)
None
None
 0.95A 4m6tA-3gr8A:
undetectable		 4m6tA-3gr8A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ILE A 908
VAL A 842
VAL A 858
ARG A 856
 None
 1.17A 4m6tA-3hngA:
undetectable		 4m6tA-3hngA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i0p MALATE DEHYDROGENASE

(Entamoeba
histolytica) 		PF02615
(Ldh_2) 		4 ILE A  77
VAL A 118
VAL A  85
ARG A  78
 None
 1.34A 4m6tA-3i0pA:
undetectable		 4m6tA-3i0pA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4o TRANSLATION
INITIATION FACTOR
IF-1

(Mycobacterium
tuberculosis) 		PF01176
(eIF-1a) 		4 ILE A  68
VAL A  10
VAL A  54
ARG A  71
 None
 1.23A 4m6tA-3i4oA:
undetectable		 4m6tA-3i4oA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ib3 COCE/NOND FAMILY
HYDROLASE

(Staphylococcus
aureus) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		4 ILE A  58
VAL A  70
VAL A 119
ARG A  60
 None
 1.23A 4m6tA-3ib3A:
undetectable		 4m6tA-3ib3A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihv SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 ILE A 347
VAL A 327
VAL A 331
ARG A 343
 EDO  A   9 (-3.9A)
None
EDO  A   9 (-4.6A)
None
 1.01A 4m6tA-3ihvA:
undetectable		 4m6tA-3ihvA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jv7 ADH-A

(Rhodococcus
ruber) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ILE A 188
VAL A 176
VAL A 199
ARG A 192
 None
 0.93A 4m6tA-3jv7A:
undetectable		 4m6tA-3jv7A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkb PROBABLE
BRANCHED-CHAIN AMINO
ACID ABC
TRANSPORTER, AMINO
ACID BINDING PROTEIN

(Thermus
thermophilus) 		PF13458
(Peripla_BP_6) 		4 ILE A 301
VAL A  48
VAL A  44
ARG A 302
 None
 1.01A 4m6tA-3lkbA:
undetectable		 4m6tA-3lkbA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lvv GLUTAMATE--CYSTEINE
LIGASE

(Saccharomyces
cerevisiae) 		PF03074
(GCS) 		4 ILE A 168
VAL A  56
VAL A  69
ARG A  99
 None
 1.36A 4m6tA-3lvvA:
undetectable		 4m6tA-3lvvA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzs CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME

(Bos taurus) 		PF00067
(p450) 		4 ILE A  50
VAL A 378
VAL A  61
ARG A  52
 None
 1.27A 4m6tA-3mzsA:
undetectable		 4m6tA-3mzsA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n05 NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Streptomyces
avermitilis) 		PF00795
(CN_hydrolase)
PF02540
(NAD_synthase) 		4 ILE A 562
VAL A 312
VAL A 307
ARG A 192
 None
 1.38A 4m6tA-3n05A:
undetectable		 4m6tA-3n05A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nxk CYTOPLASMIC
L-ASPARAGINASE

(Campylobacter
jejuni) 		PF00710
(Asparaginase) 		4 ILE A 222
VAL A 276
VAL A 247
ARG A 308
 None
 1.40A 4m6tA-3nxkA:
undetectable		 4m6tA-3nxkA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ooo PROLINE DIPEPTIDASE

(Streptococcus
agalactiae) 		PF01321
(Creatinase_N) 		4 ILE A   7
VAL A  20
VAL A  46
ARG A   8
 None
 1.21A 4m6tA-3oooA:
undetectable		 4m6tA-3oooA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pnn CONSERVED DOMAIN
PROTEIN

(Porphyromonas
gingivalis) 		no annotation 4 ILE A 111
VAL A  51
VAL A  49
ARG A  47
 None
 1.09A 4m6tA-3pnnA:
undetectable		 4m6tA-3pnnA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3py7 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PAXILLIN
LD1,PROTEIN E6
CHIMERA

(Escherichia
coli;
Homo sapiens;
Deltapapillomavirus
4) 		PF00518
(E6)
PF01547
(SBP_bac_1) 		4 ILE A 117
VAL A 247
VAL A 245
ARG A 317
 None
 1.39A 4m6tA-3py7A:
undetectable		 4m6tA-3py7A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r44 FATTY ACYL COA
SYNTHETASE FADD13
(FATTY-ACYL-COA
SYNTHETASE)

(Mycobacterium
tuberculosis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ILE A 343
VAL A 334
VAL A 352
ARG A 337
 None
 1.11A 4m6tA-3r44A:
undetectable		 4m6tA-3r44A:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6j HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Pseudomonas
syringae group
genomosp. 3) 		PF13419
(HAD_2) 		4 ILE A 323
VAL A 270
VAL A 289
ARG A 308
 None
 1.20A 4m6tA-3s6jA:
undetectable		 4m6tA-3s6jA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5b PROBABLE
CHAIN-FATTY-ACID-COA
LIGASE FADD13

(Mycobacterium
tuberculosis) 		PF00501
(AMP-binding) 		4 ILE A 343
VAL A 334
VAL A 352
ARG A 337
 None
 0.99A 4m6tA-3t5bA:
undetectable		 4m6tA-3t5bA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE

(Salmonella
enterica) 		PF02769
(AIRS_C)
PF13507
(GATase_5) 		4 ILE A 530
VAL A 576
VAL A 438
ARG A 550
 None
 1.33A 4m6tA-3ummA:
undetectable		 4m6tA-3ummA:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vh1 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7

(Saccharomyces
cerevisiae) 		PF00899
(ThiF)
PF16420
(ATG7_N) 		4 ILE A 197
VAL A 225
VAL A 230
ARG A 198
 None
 1.30A 4m6tA-3vh1A:
undetectable		 4m6tA-3vh1A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w3s TYPE-2 SERINE--TRNA
LIGASE

(Methanopyrus
kandleri) 		PF00587
(tRNA-synt_2b) 		4 ILE A 367
VAL A 450
VAL A 483
ARG A 229
 None
SSA  A2002 (-4.8A)
None
None
 0.96A 4m6tA-3w3sA:
undetectable		 4m6tA-3w3sA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zq7 KDP OPERON
TRANSCRIPTIONAL
REGULATORY PROTEIN
KDPE

(Escherichia
coli) 		PF00486
(Trans_reg_C) 		4 ILE A  23
VAL A   9
VAL A  14
ARG A  25
 None
 1.38A 4m6tA-3zq7A:
undetectable		 4m6tA-3zq7A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4avc LYSINE
ACETYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00027
(cNMP_binding)
PF13302
(Acetyltransf_3) 		4 ILE A 329
VAL A 266
VAL A 263
ARG A 326
 None
 1.11A 4m6tA-4avcA:
undetectable		 4m6tA-4avcA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bf8 FPR4

(Saccharomyces
cerevisiae) 		PF00254
(FKBP_C) 		4 ILE A 360
VAL A 314
VAL A 386
ARG A 358
 None
 1.31A 4m6tA-4bf8A:
undetectable		 4m6tA-4bf8A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4byf UNCONVENTIONAL
MYOSIN-IC

(Homo sapiens) 		PF00063
(Myosin_head)
PF00612
(IQ) 		4 ILE A  45
VAL A 588
VAL A  48
ARG A 623
 None
 1.26A 4m6tA-4byfA:
undetectable		 4m6tA-4byfA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckb MRNA-CAPPING ENZYME
CATALYTIC SUBUNIT

(Vaccinia virus) 		PF03291
(Pox_MCEL)
PF10640
(Pox_ATPase-GT) 		4 ILE A 613
VAL A 617
VAL A 594
ARG A 592
 None
 1.26A 4m6tA-4ckbA:
undetectable		 4m6tA-4ckbA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d4l 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 3

(Homo sapiens) 		PF00300
(His_Phos_1)
PF01591
(6PF2K) 		4 ILE A 136
VAL A 122
VAL A  38
ARG A 133
 None
 1.21A 4m6tA-4d4lA:
undetectable		 4m6tA-4d4lA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7a TRNA
THREONYLCARBAMOYLADE
NOSINE DEHYDRATASE

(Escherichia
coli) 		PF00899
(ThiF) 		4 ILE A 139
VAL A 150
VAL A 201
ARG A 143
 None
None
GOL  A 502 (-3.7A)
None
 1.24A 4m6tA-4d7aA:
undetectable		 4m6tA-4d7aA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f99 CELL DIVISION CYCLE
7-RELATED PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A 168
VAL A 195
VAL A 117
ARG A 167
 None
 1.24A 4m6tA-4f99A:
undetectable		 4m6tA-4f99A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fn5 ELONGATION FACTOR G
1

(Pseudomonas
aeruginosa) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		4 ILE A  13
VAL A  68
VAL A  84
ARG A  11
 None
 1.21A 4m6tA-4fn5A:
undetectable		 4m6tA-4fn5A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hkt INOSITOL
2-DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 ILE A  63
VAL A  32
VAL A  30
ARG A   4
 None
 1.15A 4m6tA-4hktA:
undetectable		 4m6tA-4hktA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifr 2-AMINO-3-CARBOXYMUC
ONATE 6-SEMIALDEHYDE
DECARBOXYLASE

(Pseudomonas
fluorescens) 		PF04909
(Amidohydro_2) 		4 ILE A  43
VAL A  34
VAL A  53
ARG A  51
 None
 1.32A 4m6tA-4ifrA:
undetectable		 4m6tA-4ifrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igl YENB
YENC2

(Yersinia
entomophaga;
Yersinia
entomophaga) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN)
no annotation 		4 ILE B  25
VAL A1473
VAL B  14
ARG B  23
 None
 1.20A 4m6tA-4iglB:
undetectable		 4m6tA-4iglB:
12.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4m6t RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1

(Homo sapiens) 		PF03985
(Paf1)
PF04004
(Leo1) 		4 ILE A  30
VAL A  42
VAL A  44
ARG A 169
 SAM  A 201 (-4.2A)
SAM  A 201 (-3.8A)
SAM  A 201 (-4.2A)
SAM  A 201 (-4.3A)
 0.02A 4m6tA-4m6tA:
29.3		 4m6tA-4m6tA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN

(Thermomonospora
curvata) 		PF13458
(Peripla_BP_6) 		4 ILE A  52
VAL A 118
VAL A  47
ARG A  91
 None
 1.36A 4m6tA-4n03A:
undetectable		 4m6tA-4n03A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p4g SHIKIMATE
5-DEHYDROGENASE AROE
(5-DEHYDROSHIKIMATE
REDUCTASE)

(Mycobacterium
tuberculosis) 		PF08501
(Shikimate_dh_N) 		4 ILE A  15
VAL A  64
VAL A  10
ARG A  40
 None
 1.17A 4m6tA-4p4gA:
undetectable		 4m6tA-4p4gA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p7h MYOSIN-7,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Homo sapiens) 		PF00063
(Myosin_head)
PF01353
(GFP)
PF02736
(Myosin_N) 		4 ILE A  51
VAL A  69
VAL A  59
ARG A  54
 None
 0.94A 4m6tA-4p7hA:
undetectable		 4m6tA-4p7hA:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pyt UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE

(unidentified) 		PF01565
(FAD_binding_4)
PF02873
(MurB_C) 		4 ILE A  63
VAL A  38
VAL A  80
ARG A  61
 FAD  A 401 ( 4.1A)
None
None
FAD  A 401 (-4.0A)
 1.36A 4m6tA-4pytA:
undetectable		 4m6tA-4pytA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qb9 ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycolicibacterium
smegmatis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		4 ILE A 260
VAL A 236
VAL A 224
ARG A 232
 None
 1.38A 4m6tA-4qb9A:
undetectable		 4m6tA-4qb9A:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlb PROBABLE GLYCOGEN
[STARCH] SYNTHASE

(Caenorhabditis
elegans) 		PF05693
(Glycogen_syn) 		4 ILE A 216
VAL A  46
VAL A 193
ARG A 183
 None
 1.27A 4m6tA-4qlbA:
undetectable		 4m6tA-4qlbA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 ILE A2838
VAL A2958
VAL A2971
ARG A2955
 None
 1.33A 4m6tA-4qyrA:
undetectable		 4m6tA-4qyrA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT

(Aquincola
tertiaricarbonis) 		PF01642
(MM_CoA_mutase) 		4 ILE A 226
VAL A 278
VAL A 271
ARG A 223
 None
 1.09A 4m6tA-4r3uA:
undetectable		 4m6tA-4r3uA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvo PHENYLACETATE-COENZY
ME A LIGASE

(Bacteroides
thetaiotaomicron) 		PF00501
(AMP-binding)
PF14535
(AMP-binding_C_2) 		4 ILE A 269
VAL A 266
VAL A 286
ARG A 301
 None
 1.28A 4m6tA-4rvoA:
undetectable		 4m6tA-4rvoA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tko EMRA

(Aquifex
aeolicus) 		PF13437
(HlyD_3)
PF13533
(Biotin_lipoyl_2) 		4 ILE B 370
VAL B 296
VAL B 294
ARG B 372
 None
 1.21A 4m6tA-4tkoB:
undetectable		 4m6tA-4tkoB:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xr9 CALS8

(Micromonospora
echinospora) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 ILE A 117
VAL A  90
VAL A  85
ARG A 120
 None
 1.02A 4m6tA-4xr9A:
undetectable		 4m6tA-4xr9A:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yrd CAPSULAR
POLYSACCHARIDE
SYNTHESIS ENZYME
CAP5F

(Staphylococcus
aureus) 		PF01370
(Epimerase) 		4 ILE A 316
VAL A 311
VAL A 369
ARG A 307
 None
 1.27A 4m6tA-4yrdA:
undetectable		 4m6tA-4yrdA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ajz 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 3

(Homo sapiens) 		PF00300
(His_Phos_1)
PF01591
(6PF2K) 		4 ILE A 136
VAL A 122
VAL A  38
ARG A 133
 None
 1.20A 4m6tA-5ajzA:
undetectable		 4m6tA-5ajzA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czy LEGIONELLA EFFECTOR
LEGAS4

(Legionella
pneumophila) 		PF00023
(Ank)
PF00856
(SET) 		4 ILE A  98
VAL A 117
VAL A 119
ARG A 131
 None
 0.94A 4m6tA-5czyA:
undetectable		 4m6tA-5czyA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ees 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE

(Corynebacterium
glutamicum) 		PF01113
(DapB_N)
PF05173
(DapB_C) 		4 ILE A   3
VAL A  51
VAL A 229
ARG A 230
 None
 1.32A 4m6tA-5eesA:
undetectable		 4m6tA-5eesA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eny POLYKETIDE SYNTHASE
PKSL

(Bacillus
subtilis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 ILE A 298
VAL A 407
VAL A 420
ARG A 404
 None
 1.34A 4m6tA-5enyA:
undetectable		 4m6tA-5enyA:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eo6 COPROPORPHYRINOGEN
OXIDASE

(Acinetobacter
baumannii) 		PF01218
(Coprogen_oxidas) 		4 ILE A  23
VAL A 103
VAL A  69
ARG A  56
 None
ACT  A 400 (-4.6A)
None
None
 1.32A 4m6tA-5eo6A:
undetectable		 4m6tA-5eo6A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyi NON-STRUCTURAL
PROTEIN 11

(Porcine
reproductive
and respiratory
syndrome virus) 		no annotation 4 ILE A 108
VAL A 181
VAL A 146
ARG A 113
 None
 1.33A 4m6tA-5eyiA:
undetectable		 4m6tA-5eyiA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gan SPLICEOSOMAL PROTEIN
DIB1

(Saccharomyces
cerevisiae) 		PF02966
(DIM1) 		4 ILE D  49
VAL D  58
VAL D  53
ARG D  52
 None
 1.01A 4m6tA-5ganD:
undetectable		 4m6tA-5ganD:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkf ENDONUCLEASE ENDOMS

(Thermococcus
kodakarensis) 		PF01939
(NucS) 		4 ILE A 139
VAL A 177
VAL A 166
ARG A 155
 None
 1.21A 4m6tA-5gkfA:
undetectable		 4m6tA-5gkfA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus musculus) 		PF00145
(DNA_methylase)
PF01426
(BAH) 		4 ILE A1416
VAL A1550
VAL A1552
ARG A1574
 None
 1.04A 4m6tA-5gutA:
undetectable		 4m6tA-5gutA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus musculus) 		PF00145
(DNA_methylase)
PF01426
(BAH) 		4 ILE A1571
VAL A1550
VAL A1552
ARG A1574
 None
 1.03A 4m6tA-5gutA:
undetectable		 4m6tA-5gutA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz1 MESO-DIAMINOPIMELATE
D-DEHYDROGENASE

(Ureibacillus
thermosphaericus) 		PF01113
(DapB_N)
PF16654
(DAPDH_C) 		4 ILE A  63
VAL A  33
VAL A  31
ARG A   5
 None
 1.40A 4m6tA-5gz1A:
undetectable		 4m6tA-5gz1A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ho1 MAGNETOSOME PROTEIN
MAMB

(Magnetospira
sp. QH-2) 		PF16916
(ZT_dimer) 		4 ILE A 272
VAL A 244
VAL A 282
ARG A 269
 None
 1.13A 4m6tA-5ho1A:
undetectable		 4m6tA-5ho1A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hsx PUTATIVE
ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE

(Paraburkholderia
xenovorans) 		PF02668
(TauD) 		4 ILE A 129
VAL A  52
VAL A 255
ARG A 131
 None
 1.36A 4m6tA-5hsxA:
undetectable		 4m6tA-5hsxA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 ILE A 224
VAL A 196
VAL A 268
ARG A 226
 None
 1.13A 4m6tA-5j6sA:
undetectable		 4m6tA-5j6sA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jtw COMPLEMENT C4-A

(Homo sapiens) 		PF00207
(A2M)
PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		4 ILE B 772
VAL B 927
VAL B 914
ARG B 916
 None
 0.67A 4m6tA-5jtwB:
undetectable		 4m6tA-5jtwB:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5keu TAURINE DIOXYGENASE

(Paraburkholderia
xenovorans) 		PF02668
(TauD) 		4 ILE A 129
VAL A  52
VAL A 255
ARG A 131
 None
 1.36A 4m6tA-5keuA:
undetectable		 4m6tA-5keuA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzo UDP-GLUCOSE-GLYCOPRO
TEIN
GLUCOSYLTRANSFERASE-
LIKE PROTEIN

(Chaetomium
thermophilum) 		PF06427
(UDP-g_GGTase) 		4 ILE A 461
VAL A 497
VAL A 465
ARG A 463
 None
 1.33A 4m6tA-5mzoA:
undetectable		 4m6tA-5mzoA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5osq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ZONA
PELLUCIDA
SPERM-BINDING
PROTEIN 3

(Escherichia
coli;
Mus musculus) 		PF00100
(Zona_pellucida)
PF13416
(SBP_bac_8) 		4 ILE A 117
VAL A 247
VAL A 245
ARG A 317
 None
 1.36A 4m6tA-5osqA:
undetectable		 4m6tA-5osqA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wuq ECF RNA POLYMERASE
SIGMA FACTOR SIGW

(Bacillus
subtilis) 		PF04542
(Sigma70_r2)
PF08281
(Sigma70_r4_2) 		4 ILE A 134
VAL A 144
VAL A 146
ARG A  37
 None
 1.03A 4m6tA-5wuqA:
undetectable		 4m6tA-5wuqA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wvm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TWO-COMPONEN
T SYSTEM SENSOR
KINASE

(Escherichia
coli;
Serratia
marcescens) 		no annotation 4 ILE A 118
VAL A 248
VAL A 246
ARG A 318
 None
 1.39A 4m6tA-5wvmA:
undetectable		 4m6tA-5wvmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x00 NUCLEOSIDE
DIPHOSPHATE KINASE

(Vibrio cholerae) 		no annotation 4 ILE A 129
VAL A  74
VAL A  76
ARG A   5
 None
 1.35A 4m6tA-5x00A:
undetectable		 4m6tA-5x00A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xsj PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR

(Clostridium
beijerinckii) 		PF13407
(Peripla_BP_4) 		4 ILE X 112
VAL X 261
VAL X 100
ARG X 111
 None
 1.40A 4m6tA-5xsjX:
undetectable		 4m6tA-5xsjX:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE

(Homo sapiens) 		no annotation 4 ILE A 142
VAL A 120
VAL A 112
ARG A 144
 None
None
None
PO4  A 602 (-3.9A)
 1.25A 4m6tA-6dd3A:
undetectable		 4m6tA-6dd3A:
undetectable